Gene Y48G9A.9 in Caenorhabditis elegans

Synonym: CELE_Y48G9A.9, Y48G9A.9

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf14
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP219_AA protein Get Run
CeleP219_AA_54-334 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 44-353 5.4e-210 690.2 In-house 1-310 (310) alignment 
Range on Protein: 44-353
Range on HMM: 1-310/310.0
KKTDDHHRKYVETLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRYEDYIHANYVKTNYLRNTFICTQ
|||||||.||...|.||||||||||||||.||||||||.||||||.||.|..|||||||||||.||.||||.|||||||||||||||||||||.||||.|
kktddhhlkylkalenfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsq

GPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESSDEFEICNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNW
|||||||||||||||||||||||.|||..|||||||||||||||||||||||||||..|||.||||||||||||||||||||||||||||||.|||||||
gplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnw

PDRGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVSEKA
|||||||||||||||||||||||||||||||||..|...||||.....|||||||||.||..|||.|.||.|||||.|||.|.||.|.||||||.|.||.
pdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargetevaeki

LAAADAFLKS
|..|||||||
llladaflks
0040438 (Phosphotyrosine protein) phosphatases II 56-333 3.1e-78 258.5 In-house 4-276 (317) alignment 
Range on Protein: 56-333
Range on HMM: 4-276/317.0
TLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSR-YEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFW
 |....    |..  .| .....|. .. .. .. ....|..||||.|... | .||||. ....   |||.|.||.. .|...||.|||||..|. |||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMIFQERAESILMLCKTMEEGRPKCVGYWPSlGVTETYGCIRVTNMGES-SDEFEICNLAVTFVPDNvpvdeqpanlKELRVNLIKWPNWPDRGVPDekC
||..... ..|.||....| ||.||  |||. | | ||| ..||...|   ..... .| |.   |.          ....|. . ...||| |||.   
rmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgds..........esrtvthfhytgWpdhgvpp..s

HTVPQRLLAQVR------HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
..  ...| .||      .||..||||||.||||...|.. ... |... .||.||.. |||.||....||. || ....... . 
pdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0050432 (Phosphotyrosine protein) phosphatases II 63-333 8.1e-77 253.9 In-house 35-299 (308) alignment 
Range on Protein: 63-333
Range on HMM: 35-299/308.0
ATEKLGIEGLAKQYRKLDAQQD-SSLTFEAFKQNMHKNRYSDVVCRDTTRVKLtidkSRYEDYIHANYVKTN--YLRNTFICTQGPLQHTIIDFWRMIFQ
  ..|.. .| .....| ....  . .. ....|..||||.|... | .||||    .   |||.|.||..   .|...||.|||||..|. |||||...
lekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

ERAESILMLCKTMEEGRPKCVGYWPSL--GVTETYGCIRVTNMGESS-DEFEICNLAVTFVPdnvpvdeqpaNLKELRVNLIKWPNWPDRGVPD--EKCH
.. . | ||.|..| ||.||  |||.   | ...|| ..||.. | . |.. . .| .|..           . ....|. . ..|||| |||.  | . 
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg..........dgesrtvthfhytnWpdhgvPpspeill

TVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
.  ...  . ..||.|||||||.||||...||. ... |... .||..|..  ||.||....||. |||...|... ..
dflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
DSPc_SM00195 72-333 3.8e-76 251.3 In-house 2-262 (263) alignment 
Range on Protein: 72-333
Range on HMM: 2-262/263.0
LAKQYRKLDAQQ-DSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS-RYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLC
| ....||.... ... | ...|.|..||||..... | |||||. ...   .|||.|||.|..  ....|.|||||..|. |||||...|. . |.||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KTMEEGRPKCVGYWPSL-GVTETYGCIRVTNMGESSDE--FEICNLAVTFVPDnvpvdeqpanLKELRVNLIKWPNWPDRGVPD--EKCHTVPQRLLAQV
. .|.|. ||  |||.  | .||.| |.|... . ...  ... .| .|.  .           .. .|. ... ||||.||||  ...  . . .  . 
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..........eetrkvtqyqyknWpdhgvpdstksvlellravkksk

R--HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
.  .||.|||||||.||||..|.......||... |||..||..||||||....||. |||.|........
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 72-333 3.8e-76 251.3 In-house 2-262 (263) alignment 
Range on Protein: 72-333
Range on HMM: 2-262/263.0
LAKQYRKLDAQQ-DSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS-RYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLC
| ....||.... ... | ...|.|..||||..... | |||||. ...   .|||.|||.|..  ....|.|||||..|. |||||...|. . |.||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KTMEEGRPKCVGYWPSL-GVTETYGCIRVTNMGESSDE--FEICNLAVTFVPDnvpvdeqpanLKELRVNLIKWPNWPDRGVPD--EKCHTVPQRLLAQV
. .|.|. ||  |||.  | .||.| |.|... . ...  ... .| .|.  .           .. .|. ... ||||.||||  ...  . . .  . 
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..........eetrkvtqyqyknWpdhgvpdstksvlellravkksk

R--HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
.  .||.|||||||.||||..|.......||... |||..||..||||||....||. |||.|........
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0051299 (Phosphotyrosine protein) phosphatases II 54-332 7.5e-76 250.6 In-house 7-285 (288) alignment 
Range on Protein: 54-332
Range on HMM: 7-285/288.0
VETLNNFIIATEKLGIEGLAKQYRKLDAQQ-DSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS-RYEDYIHANYVKTNYLRNTFICTQGPLQHTII
|| | ... .. . |. ||......| ... | .|.. ....|..||||||... | .||||.  ..    |||.|.|... .| ..||.|||||..|. 
veellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntve

DFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlGVTETYGCIRVTNMGESSdefeiCNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDE
|||||..... . | ||.|..| || ||  |||. | ..||| |.||.. | .     ..  ....   ...|    . ....|. . ..|||| |||| 
dFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.....lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

KCHTVPQRLLAQVR----HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
  . .    |..      .||.|||||||.||||...||. ... |... .||..|..  ||.|| ...||. ||........ .
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0036941 (Phosphotyrosine protein) phosphatases II 76-333 9.9e-75 246.9 In-house 19-277 (297) alignment 
Range on Protein: 76-333
Range on HMM: 19-277/297.0
YRKL-DAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLtidKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEE
...| . . . ||.  ....|..||||.|... | |||||   ..   |||.|.||.. .| ..||.|||||..|. |||||..... ..|.||.. .| 
feellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel

GRPKCVGYWPSL-GVTETYGCIRVTNMGESS---DEFEICNLAVTFVPDNvpvdeqpanlKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQV------
||.||  |||.  | . ||| ..||......   |.. . .| ||.. ..          ....|. . ...||| |||.   . .    |..       
grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng..........esrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

RHGPCVVHCSAGIGRTGCVVALEFAYNKLD---RGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
..|| .||||||.||.|...|.. ... |.   .  .||. |.. .||.||....||. ||........ . 
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0046845 (Phosphotyrosine protein) phosphatases II 72-333 2e-74 245.8 In-house 2-274 (284) alignment 
Range on Protein: 72-333
Range on HMM: 2-274/284.0
LAKQYRKLDAQQDS---SLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS--RYEDYIHANYVKTN-----YLRNTFICTQGPLQHTIIDFWRMIFQER
| .....|  .. .   ||.. ....|..||||.|... | .||||.  ..     |||.|.||..      | ...||.|||||..|. |||||.....
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

AESILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESS-DEFEICNLAVTFVPDnvpvdeqpaNLKELRVNLIKWPNWPDRGVPD------EKCH
.. | ||....| || ||  |||. | . ||| ..||.. |   | . . .| .|..           . ....|. . ...|||.|||.      | ..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy.........tgesrtvthfhytswpdhgvppspedlleflr

TVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGL---KVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
.| . | .  ..|| |||||||.||||...||. ... |...    .||..|..  ||.|| ...||. ||........ ..
lvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 62-331 2.6e-73 242.8 In-house 19-302 (307) alignment 
Range on Protein: 62-331
Range on HMM: 19-302/307.0
IATEKLGIEGLAKQYRKLDAQQD---SSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS--RYEDYIHANYV--------KTNYLRNTFICTQGPLQH
  . . ...||.|...||  ...    . .. ....|..||||.|... | |||||.  ..     |||.|.||        .. .| ..||.|||||..
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESS-DEFEICNLAVTFVpdnvpvdeqPANLKELRVNLIKWPNWPDRG
|. |||||..... . |.||....| ||.||. |||. | . ||| ..||...|.  |.. . .| ||             . ....|. . ...||| |
tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.........dgtgesrtvthfhytgwpdhg

VPDEKCHTVPQRLLAQV------RHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLK---VDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
||.   ...    ...       ..||..||||||.||||...|.  ..  |... .   ||..|.. .||.|| ...|.. || ....... 
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 43-331 3.2e-73 242.1 In-house 5-287 (297) alignment 
Range on Protein: 43-331
Range on HMM: 5-287/297.0
YKKTDDHHRKYVETLNNFIIATEKLGIEGLAKQYRKLDAQQDSsLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS--RYEDYIHANYVKTNYL-RNTF
.... ..  .... |. ..  . .... .| ... .|  ....  .. ....|..||||.|... | .||||.  ..     |||.|.||.. .|  ..|
rdallesipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

ICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRpKCVGYWPSLGVteTYGCIRVTNMGES-SDEFEICNLAVTFvpDNvpvdeqpanlKELRVNLI
|.|||||..|. |||||..... ..|.||.|..| || ||. |||. |   ||| ..||....   | . . .| ||   ..          ... |. .
IatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ng..........esrtvthf

KWPNWPDRGVPDEKCHTVPQRLLAQV------RHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
 ...||| |||.   .      |..       ..||..||||||.||||...|.  ... |... .||..|.. |||.|| ...||. || ....... 
qytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0043336 (Phosphotyrosine protein) phosphatases II 55-331 6.5e-73 240.9 In-house 5-275 (278) alignment 
Range on Protein: 55-331
Range on HMM: 5-275/278.0
ETLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIIDF
..| ....   . .  .| ... .|. ..  . .. ....|..||||.|... | .||||. .....  |||.|.||..    ..||.|||||..|. ||
kdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedF

WRMIFQERAESILMLCKTMEEGRPKCVGYWPslGVTETYGCIRVTNMGES-SDEFEICNLAVTFVPDNvpvdeqpanlKELRVNLIKWPNWPDRGVPDek
|||..... ..|.||.. .| ||.||. |||  | ..||| ..||...|   | . . .| ||   |.          ... |. . ...||| |||.  
wrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdg..........esrtvthyhylgwpdhgvpe..

CHTVPQRLLAQ------VRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
  .  ...| .       ..|| .||||||.||||...||. ... |.....||.||.. |||.||....||. || ....... 
slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0047943 (Phosphotyrosine protein) phosphatases II 64-332 4.1e-72 238.2 In-house 6-271 (273) alignment 
Range on Protein: 64-332
Range on HMM: 6-271/273.0
TEKLGIEGLAKQYRKLDAQQD-SSLTFEAFKQNMHKNRYSDVVCRDTTRVKLtidKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERA
...||. .|......|  ...  . .. ....|..||||.|... | .||||   ..   |||.|.||.. .| ..||.|||||..|. |||||......
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

ESILMLCKTMEEGRPKCVGYWPSLGV--TETYGCIRVTNMGESS-DEFEICNLAVTFVPdnvpvdeqpaNLKELRVNLIKWPNWPDRGVPDEKCHTVPQR
. | ||....| ||.||  |||. |   ..||| ..||...| . | . . .| .|..           . ... |. . ...||| |||.   . .   
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg..........tgesrtvthfhytgwpdhgvppslesllefi

LLAQV------RHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
 |..       ..|| |||||||.||||...||. ... | .. .||..|..  ||.||  ..||. ||........ .
elvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
Y_phosphatase Protein-tyrosine phosphatase 95-330 6.4e-68 224.0 Pfam-A 1-234 (235) alignment 
Range on Protein: 95-330
Range on HMM: 1-234/235.0
NMHKNRYSDVVCRDTTRVKLTIDKSRyEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWP-SLGVTETYG
|..||||.|... | |||||. .... .|||.|||||.    ..||.|||||..|| |||||..||. ..| ||.. .|.|| ||  ||| . . ..|||
nkkknRykdilpydktrvklkgsegp.sdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

CIRVTNM-GES--SDEFEICNLAVTFVPDNVpvdeqpanlKELRVNLIKWPNWPDRGVPDEKCHTV--PQRLLAQV--RHGPCVVHCSAGIGRTGCVVAL
 |.|...  |.  ..|. . .| ..   ..          .. .|. . . ||||.|||... . .   ...  .   ..||.|||||||.||||..|||
dikvelkekekedekeytlrklelkkkkees.........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

EFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
... ..|... .||  .|. ||||||....|.. || .......
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 95-330 6.4e-68 224.0 In-house 1-234 (235) alignment 
Range on Protein: 95-330
Range on HMM: 1-234/235.0
NMHKNRYSDVVCRDTTRVKLTIDKSRyEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWP-SLGVTETYG
|..||||.|... | |||||. .... .|||.|||||.    ..||.|||||..|| |||||..||. ..| ||.. .|.|| ||  ||| . . ..|||
nkkknRykdilpydktrvklkgsegp.sdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

CIRVTNM-GES--SDEFEICNLAVTFVPDNVpvdeqpanlKELRVNLIKWPNWPDRGVPDEKCHTV--PQRLLAQV--RHGPCVVHCSAGIGRTGCVVAL
 |.|...  |.  ..|. . .| ..   ..          .. .|. . . ||||.|||... . .   ...  .   ..||.|||||||.||||..|||
dikvelkekekedekeytlrklelkkkkees.........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

EFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
... ..|... .||  .|. ||||||....|.. || .......
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0045098 (Phosphotyrosine protein) phosphatases II 77-331 8.1e-68 224.1 In-house 15-270 (278) alignment 
Range on Protein: 77-331
Range on HMM: 15-270/278.0
RKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKltidksryeDYIHANYVKTNylRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGR
..|   . |. |.  .  |..||||.|... | .|||         |||.|.|...   ...||.|||||..|. |||||..... ..|.||.. .| ||
fllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

PKCVGYWPSlGVTETYGCIRVTNMGESSDefeicNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQV------------
 ||. |||. | ..||| ..||.. |.       .  .. .   . .  ....|... |. .....||| |||..  ..  ..|| ..            
ekcaqywpe.ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------RHGPCVVHCSAGIGRTGCVVALEFAYNKLdrGLKVDFEEIITELRKQRAQ-CIQTEIQYLYIHRVMIA
       ..||..||||||.||||..||.   .  |  . .||..|...|||.|| . ..|.. || ....... 
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_PTPRD_pd Subfamily PTPRD 55-353 1.1e-67 224.0 In-house 8-302 (564) alignment 
Range on Protein: 55-353
Range on HMM: 8-302/564.0
ETLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDF
..|....   .. .   . ..|.|.. .| .. .  . ..| .||||...|  |..||.| ....    ||| |.....   |...| |||||..|| ||
aelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedF

WRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGvTETYGCIRVTNMGE-SSDEFEICNLAVtFVPDnvpvdeqpaNLKELRVNLIKWPNWPDRGVPDEK
|||..... ..| || |. |.|. ||  |||. | ||||| . || . |    ..||... .    .         . .   |.  .. .|||.|||.. 
WRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkk.........ssesreVrqFhFtsWPdhgvpesa

CHTVP----QRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI-AFARGETDVSEKALAAA
.. .      | |..  .|| |||||||.||||. ....   ...    .||  .....|||||   .||| || .||...  | | |.|.|. ..| ..
tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqh

DAFLKS
   |..
lqkLae
0040439 (Phosphotyrosine protein) phosphatases II 88-330 1.6e-67 223.0 In-house 4-243 (249) alignment 
Range on Protein: 88-330
Range on HMM: 4-243/249.0
TFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSl
..  .. |..||||.|... | .||||.| ....  |||.|.|... |  ..||.|||||..|. |||||..... ..|.||....| || ||  |||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

GVTETYGCIRVTNMGESS-DEFEICNLAVTFVpdnvpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQV------RHGPCVVHCSAGIGR
| . .|| ..||.. . . |.. . .| .|..           . ....|. | ...||| |||.   ...    ...       ..||..||||||.||
ggsleygdftvtllsvevkddytvrtleltnl..........ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgR

TGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
||...|.  ... |.. |.||.||.. .||.|| ...|.. || .......
tGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 60-332 2.1e-66 219.0 In-house 6-276 (307) alignment 
Range on Protein: 60-332
Range on HMM: 6-276/307.0
FIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSrYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQ
..  | . |.. |  ..|.|  ..  ..| |||. | .||||.|| |.| .|. ...|     |||||||. .    . |||.||||. |. .|| |. |
wvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiq

ERAESILMLCKTMEEGRPKCVGYWPSL-GVTETYgcirvtnmGESSDEFEICNLAV-TFVPDNVPVD----EQPANLKELRVNLIKWPNWPDRGVPDEKC
|. ||..||||..| .. ||  |||   | . ..        ||...   . || . .. ||.  ..    .     |   .. ..| ||||||||. . 
ekvesvimlckvielakikceqywpleegqklvf........geapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinl

HTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLK-VDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
 ..      .  . | |||||||.||.| .||. .  .|. .|    | .... |||.||  .||||.||||.|||.. .
tainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
0042113 (Phosphotyrosine protein) phosphatases II 89-330 5e-66 217.9 In-house 3-240 (245) alignment 
Range on Protein: 89-330
Range on HMM: 3-240/245.0
FEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlG
. ... |..||||||... | |||||. |....  |||.|.||.. .  ..||.|||||..|. |||||..... ..|.||....| ||.||  |||. |
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

VTETYGCIRVTNMGESSdEFEICNLAVTFVPDnvpvdeqpANLKELRVNLIKWPNWPDRGVPD-----EKCHTVPQRLLAQVRHGPCVVHCSAGIGRTGC
 . ||| ..||...| . . ...   .. ...         . ... |. . . .||| ||||     ....   .. ||. ..||..||||||.||||.
esltygdftvtllseeh.lddytvrtlevtnl........gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

VVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
..|.  ... |.. |.|..||.. |||.|| ...||. || .......
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 60-350 1.4e-63 209.4 In-house 12-304 (305) alignment 
Range on Protein: 60-350
Range on HMM: 12-304/305.0
FIIATEKLGIEGLAKQYRKLDAQQDSSlTFEAFK--QNMHKNRYSDVVCRDTTRVKLtiDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMI
|.  | . | .|| ...  .   .|    ..|||  |. .|||| || | |  ||||  . .   .||||||| |    . ||||| ||..|  ||| | 
fvkrtlekgpaglraefvamkrfndfe.kmkafkeaqeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymc

FQERAESILMLCKTMEEGRPKCVGYWPSLGVTE---TYGCIRVTNMGESSDEFEICNLAVTFVPDNVPVDEQPANlKELRVNLIKWPNWPDRGVPDEKCH
.|.. |.|.|||. .| |  ||. |..|    .     .  ...   ||| .... . | . | . | | | | . | ..|.  .| .|||||||     
lqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpge.karkvthyhwidwpdrgvpaadla

TVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVD-FEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVSEKALAAADAF
 .     |.. .|| |||||||||||| || ||.  ..|  | ...  . |.  .|.|| . |||. |||..|.|.. . | .  . |.  .| .||
ilellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkeaykaf
subfamily_PTPRB_pd Subfamily PTPRB 70-336 8.1e-63 207.2 In-house 25-288 (293) alignment 
Range on Protein: 70-336
Range on HMM: 25-288/293.0
EGLAKQYRKLDAQ-QDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILM
 .....| .| |  .| . ..   ..|  ||||....  |..|||| ...... .||| |||.. .  .. || ||||| .|. |||||....... |.|
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGES-SDEFEICNLAVTFvpdnvpvdeqpaNLKELRVNLIKWPNWPDRGVPDEKC------HTVPQRL
| ...|.|. ||  |||.   . .|| |.|| . |.  ... | .|...             . .| .|.  ..  ||| |||..        .|| ...
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek............ekeerkvrqyhftsWpdhgvPektktlldfvrtvreai

LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGE
  . ...| |||||||.||||  .||.   .....   ||   |..|||..|.. .||| ||..||...... | .
ektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 58-333 2.1e-60 198.9 In-house 12-289 (305) alignment 
Range on Protein: 58-333
Range on HMM: 12-289/305.0
NNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQ------NMHKNRYSDVVCRDTTRVKLtiDKSRYEDYIHANYVKTNYLRN-TFICTQGPLQHTI
..|.. .  .|.. | ...|.|       .|  ||.       .. ||||.|| |.| . |||  ||    ||||||||    . .  |||.||||..||
eqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl..dkpspsdyihanyvgcpmipekrficaqgpldqti

IDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSL-GVT-ETYGCIRVTNMGESSDEFEICNLAVTFVpdNVPV-DEqpanlKELRVNLIKWPNWPDRG
 .|| |. |.. | |.|||||.| |. ||  |||   |   |  . | | |.  |       .. .| .  |.    .     ... |  ..| .|||||
defwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitll..nltysgd.....qkmsvrhlqwtewpdrg

VPDekCHTVPQRLLAQVRH--GPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKV-DFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
||   |.     ||. .|    | |||||||||||| .||.|.  .|.    ..  . |..  || |||  ||...|||.|||||. . 
vpp..ckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 62-335 1.7e-58 193.0 In-house 13-283 (288) alignment 
Range on Protein: 62-335
Range on HMM: 13-283/288.0
IATEKLGIEGLAKQYRKL-DAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTI-DKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQ
. ... . .|. ..|..|   ....| |     .| .|||| ...  | .||||.  .. . .||| |.|.. .  ....|.|||||..|. |||.....
akksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

ERAESILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESSDEfEICNLAVTFVpdnvpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQR
.... |.|| . .|.|. ||  |||. .  . || . || ...   | .. .  .  .           . .||...  ..  ||| |||. |   .  .
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskele.dfvlrkllle..........kkkteleitqyqylaWpdhgvPeskapllell

LLAQVR----HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA--RG
   .|      || .||||||.||||  .||. . .....  ..|  .....||||||. .||. || .|..|..  .  .|
rqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg
0037934 (Phosphotyrosine protein) phosphatases II 91-330 2e-58 193.2 In-house 6-239 (243) alignment 
Range on Protein: 91-330
Range on HMM: 6-239/243.0
AFKQNMHKNRYSDVVCRDTTRVKLtidKSryEDYIHANYVKTNylrNTFICTQGPLQHTIID----FWRMIFQERAESILMLCKTMEEGRPKCVGYWPsl
 ...|..||||||... | .||||   ..  .|||.||...     ...|.|||||..|. |    ||||..... ..|.||....| || ||. |||  
llpenlsknrysdilpydhsrvkl...eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

GVTeTYGCIRVTNMGESSD-EFEICNLAVTFVP-DNVPvdeqpanlkeLRVNLIKWPNWPDRGVPDE--KCHTVPQR----------LLAQVRHGPCVVH
| . ||| ..||...|..  .. . .| .. .. |...          . |  . . .||| ||||.   .    .           |||  ..||..||
gev.tygdftvtllseehlddytvrtlllenldlddlt..........rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVH

CSAGIGRTGCVVALEFAYNKLdrglKVDFEEIITELRKQRAQ-CIQTEIQYLYIHRVMI
||||.||||...|.   . .|    .||.||.. .||.|| . ..||. || .......
CsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPN6_pd Subfamily PTPN6 54-339 4.4e-58 191.7 In-house 13-303 (306) alignment 
Range on Protein: 54-339
Range on HMM: 13-303/306.0
VETLNNfiiATEKLGIEGLAKQYRKL---DAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRYEDYIHANYVKTN--YLRNTFICTQGPLQH
|. |..    .|.|. .|. ... .|   .|..  | .  | ..|..||||  ..  | |||.|. ..   .||| |||.|..    ....| ||| |..
vselek...eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclet

TIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESS-DEFEICNLAVTFVpdnvpvdeqPANLKELRVNLIKWPNWPDRG
|. |||||..|| .. |.|. | .| |. ||. |||.   .|.|| |.|||. |.| ..... .| |. .           . .| .|   .. .||| |
tvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk.........kkkkeerevfqyhfksWPdhg

VPDEKCHT------VPQRLLA--QVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDR-G--LKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGE
|| .. .       | ..     . ..|| |||||||||||| .. ..   ... . |   ..| ....  .|.|| . .||| || ...... .. . .
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk

TDV
...
kkl
subfamily_PTPN12_pd Subfamily PTPN12 78-337 4.7e-58 191.4 In-house 23-281 (290) alignment 
Range on Protein: 78-337
Range on HMM: 23-281/290.0
KLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGR
|. |..  | .    ..|..|||| |..  |..||.|. ...   .||| ||..|  . . ..| .|||| .|. ||||||.. . | ..|.|. .| |.
kykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk

PKCVGYWPSLGVTET-YGCIRVTNMGESS--DEFEICNLAVTFVpdnvpvdeqpanLKELRVNLIKWPNWPDRGVPDEKCHTVP----QRLLAQVRHGPC
 ||  |||. | .|. .| ..||.. |    |.| |  |.|..              .. .|. ... .|||.|||  . . .      | | .  . | 
kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq............kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPl

VVHCSAGIGRTGCVVALEFAYNKLDRGLK---VDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGET
|||||||.|||| ..|...... | ..     .|  ....|||||||  .||. || .... .. . . | 
vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkel
subfamily_PTPRG_pd Subfamily PTPRG 59-346 2.3e-57 189.5 In-house 8-301 (563) alignment 
Range on Protein: 59-346
Range on HMM: 8-301/563.0
NFIIATEKLGIEGLAKQYRKLDAQQD---SSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTID--KSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDF
. ...    |  |..... .|  .        ..   ..| .||||...|  | .||||.    | .  ||| |||..  .  . || |||||..|. ||
khvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddF

WRMIFQERAESILMLCKTMEEGRPKCVGYWPSlGVTETYGCIRVTNMGEssdEFEICNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKC
||||...... | |. .  |.|| ||  |||.   .|||| ..|| . |   |  ..    |.|  |. ....    .|..|   ....||| |||. . 
WrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtliee...evlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl

HT---VPQRLLAQVR-HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA-FARGETDVSEKALAA
     | ..  |. .  || |||||||.||||  ..|.   ... .  .|.  ...  .| ||   .||| ||...| ...   | .||..... . .
pvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 56-346 2.9e-57 189.1 In-house 6-294 (318) alignment 
Range on Protein: 56-346
Range on HMM: 6-294/318.0
TLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQ-NMHKNRYSDVVCRDTTRVKLTIDKS-RYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDF
 |.. .   .. |   | ..| .|. ..... .... .. | .|||| ...  |.|||||.  ..    ||| |||.  .  ....| .|.|| .|| ||
dleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDf

WRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGvTETYGCIRVTNMgessDEFEICNLAVTfvpdNVPVDEQPANlKELRVNLIKWPNWPDRGVPDEKC
|||...  .  |.|| ...|.|. |.  |||| | ...|| ..|. .    .|.|. .. .     .. | ..  . ..  |   .. .|||.|||.. .
WrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelk....eevelsdyvlr....efkvtrteee.esrqvrqyhytsWpdegvpesga

HTVP-----QRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA-FARGETDVSEKALAA
. .      ..  ..  .|| |||||||.||||  .|..   ...     ||  .....||.||   .||| || .|. |..   | |.|.|. . |..
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrs
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 49-333 3e-57 188.5 In-house 6-283 (290) alignment 
Range on Protein: 49-333
Range on HMM: 6-283/290.0
HHRKYVETLNNFIIATEKLGIEGLAKQYR-KLDAQ-QDSSLTFEAFKQNM--HKNRYSDVVCRDTTRVKLTidKSRYEDYIHANYVKTnyLRNTFICTQG
.|   .|....|   . | ....|||.|  ||        |  . | .|   .|||| |||| | ||| |        ||.||||||   |. .|| |||
rhsvqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk..dGydGdyvhanyvkG..lkamfiltqG

PLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPS-LGVTETYGCIRVTNMGESSDEFEICNLAVTFVpDNvpvdeqpANLKELRVNLIKWPNW
.|. |.||.|||. ||..  | |||. .|.|..||  |.|   | . |.| | |.   |.... .|    ..   |         . || ... .|   |
alkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvr.dk.......dsGkehklkhlkiksw

PDRGVPDEKCHTVpqRLLAQVR--HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
||. |.  .   .  |.|  .|   || ||||||||||||  ||.| . . |  | ..|  ...  ||. |.. .| .|||| . .... . 
pdksvalstlall..rtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 66-330 1e-56 187.1 In-house 11-273 (281) alignment 
Range on Protein: 66-330
Range on HMM: 11-273/281.0
KLGIEGLAKQYRKLDA-QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAE
.   .|....|.|| | ..|.. |    ..|..|||||..|  | ||||.|  ...   ||| ||.|..    . .| ||||. ... .||.|.......
qndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

SILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESSDEfeicnlavTFVPDNVPVdEQpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLA-
 | |. . .|.|. ||  |||    . .|| ..|... |.. .        |..  .. . |.  . .. .|. ... .||| |||..  . .  |    
aivmvtreieagklkChrYWPddnselkygdvtvkstaeeeka........tyierkfkl.er.esgetreveqlaytaWPdhGvPattkellefrkevl

--QVR--HGPCVVHCSAGIGRTGCVVALEFAYNKLDRG-LKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
  . .  . | |.|||||.||||. .||. . .....   ..| .....||||.|   .|| .|| .......
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 91-334 1.9e-56 186.2 In-house 24-269 (274) alignment 
Range on Protein: 91-334
Range on HMM: 24-269/274.0
AFKQNMHKNRYSDVVCRDTTRVKLTIDKSRYE--DYIHANYVKT-NYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLG
    . .|||| ...  ...|| |. ..|. |  .|| |||.|  ..  .... |||||..|. ||||||.||... |.|| |  |. . ||. |.|   
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

---VTETYGCIRVTNMGE-SSDEFEICNLAVTFVPDNVPvdeqpanlkelrVNLIKWPNWPDRGVPDEK------CHTVPQ-RLLAQVRHGPCVVHCSAG
   ..|.|| . ... .  . ..... .| .  . ..              |  . ...|||. .||.       .. | . |  .. . .| |||||||
dyeiserygdveikvekiverndysvrklvlkylerers............vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

IGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
|||||| .| . | ..|..  .||  .|...|| .|   .||. || .|||... ...
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 51-332 2.5e-56 186.1 In-house 8-289 (298) alignment 
Range on Protein: 51-332
Range on HMM: 8-289/298.0
RKYVETLNNFIIATEKLGIEGLAKQYRKLDAQQD----SSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTI-DKSRYEDYIHANYVKTNYLRNTFICTQGP
... ..|...   ..| .. |.|.....|.. ..     . .    ..| .||||.|..  | .|| |.  |.    ||| | ....   ||.|| ||.|
edlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaP

LQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGvTETYGCIRVTNMGES-SDEFEICNLAVTfvpdnvpvdEQPANlKELRVNLIKWPNWP
|..|. |||||. .| ...| || .. | .. |.  |||. | .|||| |.|. . .    ......|.|.         ..  . || .|  ... .||
ltetvedFWrmvteedigtiVmltnleeldktkyhkywPdeg.ketygeitvsllskeefadlivrklkvs.........kkkee.kerevrqlhftsWp

DRGVPDEKCHTVPQRL---LAQVRHG--PCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
|.||| ...  .  .      | . |  | .|.||||.||.|  .|..   ... .  .||  ...  |||.|.. .||| || .|. ... .
dkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_PTPN3_pd Subfamily PTPN3 75-331 3.5e-56 185.2 In-house 20-273 (280) alignment 
Range on Protein: 75-331
Range on HMM: 20-273/280.0
QYRKLDA-QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSryeDYIHANYVKTNY----LRNTFICTQGPLQHTIIDFWRMIFQERAESILMLC
|. .|   ... ...     .|..|||| |..  |.|||||.  ..   ||| ||||. .     | | .| |||||..|  |||.|....... |.|| 
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

KTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGEssdefeicNLAVTFVPDNVPVDEQPANlKELRVNLIKWPNWPDRGVPDEKCHTVP----QRLLAQVR
 ..|.|| ||  |||. . . .||...|.   |        .   ..|  .. . .. .. .| ..  ... .||| ||||.. . .      | | ...
tlverGrvkChqyWPetedeleygefsvkceke........detksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgk

HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
. | |||||||||||| ...|| |  ....  .|   .|. ..| |||  .||. || ..   ...
eePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 54-339 6.1e-55 181.5 In-house 6-290 (305) alignment 
Range on Protein: 54-339
Range on HMM: 6-290/305.0
VETLNNFIIATEKLGIEGLAKQYRKLDAQqDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIID
...|...|  ...   .|| .||..|  . ..|.  .  ..| .|||.....  |. |..|| ..|   .||| |.||..   ....| .||||..|. |
lddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvad

FWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLG-VTETYGCIRVTNMG-ESSDEFEICNLAVTFVPDnvpvdeqpaNLKELRVNLIKWPNWPDRGVPD
|||.|..|. ..|.||.|..|.|. ||  |||     .. .| . |.    ..  .. . .| ...  .         . ..  |   .  .||| |||.
fWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.........dkesrtvlqyqltdWPdhGvpq

EKCH--TVPQRLLAQVRHG---PCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR-GETDV
.     .. .|.  . ...   | .||||||.||||  .|.. | ..| .   ||. |.. .||..| . .||  || ..| ..      |.|..
fatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsi
subfamily_PTPRA_pd Subfamily PTPRA 76-342 3.3e-54 179.0 In-house 38-305 (330) alignment 
Range on Protein: 76-342
Range on HMM: 38-305/330.0
YRKLDA-QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTID-KSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTME
.  | | . ...|   . ..|..|||. ...  | .|| |.      . ||| | ...    ...|| .|||...|. ||||||.. .. .|.|| .  |
fnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelke

EGRPKCVGYWPSLGVTeTYGCIRVTN-MGESSDEFEICNLAVTFVPDNVPVDeqpanlKELRVNLIKWPNWPDRGVPDEKCHTVP----QRLLAQVRHGP
  . ||  |||. |.  ||| |||.    . . .. . .. |. .||.   .      |.  |. ...  ||| ||| |    .      . | |.  ||
rkeekcaqywPdeGlv.tyGnirvevedetvlvdytvrkflvqqlpdatrek......ksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagp

CVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF-ARGETDVSEK
 |||||||.||||  ..|.   ...    |||  |.. .||.||.| .||. || .|..|.  .   |.|..   
ivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvs
subfamily_Ptp69D_pd Subfamily Ptp69D 57-345 5.4e-54 178.4 In-house 9-299 (307) alignment 
Range on Protein: 57-345
Range on HMM: 9-299/307.0
LNNFIIATEKLGIEGLAKQYRKLD-AQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFW
|.. . . ..   .|||| |.||   . | | .. . | |  |||| |..  | |||||. |  . . ||| |...|.   ...||. |.|.. || |||
leealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfW

RMIFQERAESILMLCKTMEEGRPKCVGYWPSLgVTETYGCIRVTNMGE-SSDEFEICNLAVTFVPDNVPVDeqpanLKELRVNLIKWPNWPDRGVPdEKC
||| .   . | || .  |  | ||  |||    .  || | |. . | . ... | .| |. . ....        .. .|   .. .|.|  || | .
RmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgev.....edsrkvvqyhytgWkDskvP.eva

HTVP---QRL--LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR-GETDVSEKALA
...    ...  | .  ..| ||||||| ||.| .|||.   ..|    |||  |.. .||.||   .|   || ...| .. .   |.||.. . |.
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 76-334 4.5e-53 175.0 In-house 1-265 (270) alignment 
Range on Protein: 76-334
Range on HMM: 1-265/270.0
YRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVK-TNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTME
...|| .. |. .. .. .. . ||| |..   .|||.|  ...     || ||||.  .  ....|...|||. |. .|||||..|....|.|. . .|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

EGRPKCVGYWPSLG---VTETYGCIRVTNMGESSDEFeicnlavtFVPDNVPVDEQPanlKELRVNLIKWPNWPDRGVPDEKC-HTVPQRLL---AQV--
.|| ||  |||.     |. ..| |.|... |. .|.        ..  .. . |.    .| |.    . .|||.||| |.   . .. ||   ..|  
kgrkkCerYWpaepkekvkledgkikvlalseekeeg........yiltrlrleekg...eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrr

------RHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
      . .|..||||||.||||...||..| . |..  |||  .||.||||.| ...|.  || ....... .|.
sekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 54-340 6.7e-53 174.8 In-house 7-291 (319) alignment 
Range on Protein: 54-340
Range on HMM: 7-291/319.0
VETLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIID
|. |.. . | .. |  .|.|....|.  .. ...    ..| .||||....  | |||.|. .| .   ||| |... .   |. || ||.||..|| |
vqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentied

FWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGvTETYGCIRVTNM-GESSDEFEICNLAVTFVPDNVPVdeqpanlkeLRVNLIKWPNWPDRGVPDE
||||...|..  ..||.|  |... |.  |||.    |.|| . ||    |  ....| .| .    ..|            .|   .. .||| .||..
fWrmvWeeessivvmltklveklkvklkkywpeen.feeyGrlivtleeeeeledyiirklklnkkssevet.........RevkhfqyteWpdhdvPek

KCHTVP--QRL---LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR-GETDVS
    .   .|.     .  .|| |||||||.||||  ..|. . ... .   .|  ... .|| ||   .|.. || .|. ......  |.|.. 
atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteie
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 93-332 1e-51 170.6 In-house 7-241 (250) alignment 
Range on Protein: 93-332
Range on HMM: 7-241/250.0
KQNMHKNRYSDVVCRDTTRVKLTIDK-SRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPkCVGYWPSlGVTET
 || .||||.|..  | .|| |  .|  .  ||| | ....   |..|| ||||||.|| |||||...| ...|.|| .  |...  .  |||   ..|.
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.ekaek

YGCIRVTNMgeSSDEFEICNLAVTFVPDNvpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTV-----PQRLLAQVRHGPCVVHCSAGIGRTGCVVAL
|| ..|. .  |..||      . ..  .        . .|  |  ... .|||.|||..    .      |.   |.  .| .|.||||.||.|. .|.
yGdvtvsll..skeefadytkrklklska.......kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiai

EFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
.   ..| .  .||  ..|  |||.| . .... || ....... .
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_PTPRK_pd Subfamily PTPRK 93-340 2.8e-50 165.9 In-house 41-285 (314) alignment 
Range on Protein: 93-340
Range on HMM: 41-285/314.0
KQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLgvTET
..| .|||. |..  | .||.| |||     ||| |... .    . || ||||||.|. ||||....|.. ||.|| . .|.|| ||. |||    ||.
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed..tev

YGCIRVTNMGESSDEfEICNlaVTFVPDNvpvdEQPANLKELRVNLIKWPNWPDRGVPDEKCHTV---PQ-RLLAQVRHGPCVVHCSAGIGRTGCVVALE
|| |.|. .  . .. |. .   .|   .     . .  .   |. ... .||| .|| ..   .    .     . ..|. ||||||| ||||. .|..
ygdikvelvetella.elvv..rifrvek....largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaid

FAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA-FARGETDVS
   . ..|   ||  ... .||...   ..|| || .|. |..     ||| . 
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaip
subfamily_PTPN13_pd Subfamily PTPN13 75-331 2.8e-49 162.8 In-house 16-267 (273) alignment 
Range on Protein: 75-331
Range on HMM: 16-267/273.0
QYRKLDAQQDSSLTFEA-FKQNMHKNRYSDVVCRDTTRVKLTIDKSryedYIHANYVKTNYLRNTF--ICTQGPLQHTIIDFWRMIFQERAESILMLCKT
....|   .    . ..  |.|..|||| .|.  | |||||  . .    || |...| .   ...  | .|||| .|. |||.|... .|| | |. . 
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

MEEGRPKCVGYWPSLGVT--ETYGCIRVTNMGE-SSDEFEICNLAVTfvpdnvpvDEQPANLKElrVNLIKWPNWPDRGVPDEKCHTVPQ-RLLAQV--R
 |.|. ||  |||.        .. ..|....    |.| . .|||.        | . .. .|  |  ... .||| ||| .  . .   . ....   
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk........dsesgesre..vahlnfvkwPdhgvPssaaellqfvaevrrlqtd

HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
.|| ||||||||||.| ..... . . ..|  ..| .||. .||.||   .||. ||........ 
agPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 54-331 2.3e-48 159.5 In-house 4-281 (290) alignment 
Range on Protein: 54-331
Range on HMM: 4-281/290.0
VETLNNFIIATEKLGIEGLAKQYRKLDA-QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSR---YEDYIHANYVKTNYLRNTFICTQGPLQHT
|. . .|..  .. | ||  .|. .||. ... . | .  ..| ..||....| .|  |. |    ..    ..||.| |.|    .. .| ||||...|
vdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsnt

IIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVTEtYGCIRVTNMGESSDE-FEICNLAVTfvpdnvpvdEQPANLKELRVNLIKWPNWPDRG-
..|||..| ||.   |.||.. .|||. ||  |||. .... || .... . |.. . . . .| |.         .. .. ..  |   .  ||.. | 
lvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevk.........nknsagakqsvtqyqitnwdstgk

VPDEK--CHTVPQRLLAQVRH--GPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
|....   ... ..   | ..  .. |||||...||..  .|.. . ||      .|  ... ..| |. . .||. || .|..... 
vtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
0051429 (Phosphotyrosine protein) phosphatases II 121-352 2.4e-48 160.5 In-house 3-244 (272) alignment 
Range on Protein: 121-352
Range on HMM: 3-244/272.0
YEDYIHANYVKTNYL---RNTFICTQGPLQHTIIDFWRMiFQERAESILMLCKTMEEGRPKCVGYWP-----------SLGVTETYGCIRVTNMGESSDE
...||.|..|....    ........|||..|. ||||.  ...  .|..|....| || ||  |||           .   | .||..|||.. |.  .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

FeicnlavtFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAqvrHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVD------
.        .. ..  .  .  . . ..| .. . .|||.|||.| .... . ||.   .||..||||||..|||.||||   .  ...   ||      
d........yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--FEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVSEKALAAADAFLK
   ||.. |||.||.. .||| |||..........|. ..|.. .|.|| ....
lyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaid
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 54-329 6e-48 158.3 In-house 3-267 (288) alignment 
Range on Protein: 54-329
Range on HMM: 3-267/288.0
VETLNNFIIATEKLGIEGLAKQYRKLDaQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTiDKSRYedYIHANYVKTNYLRNTFICTQGPLQHTIIDF
 | .|..|    . ..||| |.||    .. |  . ..| .|  ..|| .. . |.|||||. | . .  ||.|| | ..  .. .||.| ||. ||  .
kevinawirlvlqiaveglkkeyrdsp.neasidiidsfianptrdryenlprcditrvkls.ddpdf..yiaanvvssakykrrlicaqaPlngtieel

WRMIFQERAESILMLCKTMEEGRPKCVGYWPSLgVTETYGCIRVTN-MGESSDEFEIcNLAVTFVPDNVPVDEQPanlkelRVNLIKWPNWPDRGVPDEk
|.|....  | |.|||. .| |..|   |.||  . |.    |. . . .. .. .   . |. .  . ...|.        |  . . .|.| |||.. 
WkmllesdveyivmlcellekGkeksaeyfPsk.lGekarigrlctvvkkkradidk.lvkvsllriskegeekv......ivkilhlleWdddgvPen.

cHTVPQRLLAQVR--HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
 .  | |||  ..  . | |||.|||.|||| ..   .| . |     .  ......||..| ..|||| ||||.||..
.ylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 83-342 5.3e-47 155.7 In-house 49-301 (319) alignment 
Range on Protein: 83-342
Range on HMM: 49-301/319.0
QDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCktmeegRPKCVG
. .  ||   .||  |||. ...  | ..|||  ..   . ||| | .|.    .. .| .||||. |. ||||||.. .. .|..|       . ||  
nladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWPSLGV-TETYGCIRVTNMGESSDefeicnlavtFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTV---PQ-RLLAQVRH--GPCVVHCS
|||  .| .|  . ..|. . |...          .|  .. . |.  .    ...  ..  ||| ||||     .    . | | .  .   . |||||
ywplkivikeerfkvkvdsveetae..........yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcs

AGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA-FARGETDVSEK
||.||||  ..|.   .....  .||  ... .||.|| . .|  .|| .|.  ..  .  | .||.  
aGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvamp
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 84-343 1.6e-46 154.1 In-house 14-266 (284) alignment 
Range on Protein: 84-343
Range on HMM: 14-266/284.0
DSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCktmeegRPKCVGY
 .  ||   .||  |||. ...  | ..|||  ..   . ||| | ...    .. .| |||||. |. ||||||.. .. .|..|       . ||  |
gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy

WPSLGV-TETYGCIRVTNMGESSDefeicnlavtFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTV---PQ-RLLAQVRH--GPCVVHCSA
||  .| .|  . ..|. . ||..          .|  .. . |.  . .  ...  ..  ||| ||||   . .    . | | .  .   . ||||||
wplkivikeerfkvkvdsveesee..........yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

GIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA-FARGETDVSEKA
|.||||  ..|.   .....  .||  ... .||.|| . .|  .|| .|.  ..  .  | .||.   
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpd
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 68-356 1e-45 151.1 In-house 22-297 (315) alignment 
Range on Protein: 68-356
Range on HMM: 22-297/315.0
GIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESIL
  .|. ..|  .   |   |      .| .|||| ...  | .||.|  ...    ||. ||...    .. .|..|||.  .. ||||..|.|    |.
tkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkiv

MLCKTMEEGRPKCVGYWPSLgvTETYGCIRVTNMGES-SDEFEICNLAVTFVpDNVpvdeqpanlKElrVNLIKWPNWPDRGVPDEKCHTV------PQR
|| ...|. . |.  |||      .|| | || . |   .|. .  |.|.|  ||.         .|  |  ...  ||| |||      .       | 
mltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfg.dni.........re..vvqlhytswpdmgvpkytiplmnlirtvkqh

LLAQVrhGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM-IAFARGETDVsekalaAADAFLKSYDE
  ..|  |. |||||||.||||  ..|.   ....    .|  ..|| .|..| . .|.  || .|. ..  .|  |.| .      | | .|..|| 
htnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi......aqdlylqryds
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 60-341 1.3e-45 150.3 In-house 1-277 (281) alignment 
Range on Protein: 60-341
Range on HMM: 1-277/281.0
FIIATEKLGIEGLAKQYRKLDAQQDSSLTfEAFK--QNMHKNRYSDVVCRDTTRVKLTI--DKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWR
| ....|. .. . ... .|  .  | |   .|.   | .||||... | | .||.| .   .    |||||||... .|.  .| |||| . |  ||||
famssqkmtlddfkqefsnlpgdppsdlc.tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwr

MIFQERAESILMLCKTMEEGRPKCVGYWPSlgvtETYGCIRVTNMGESSDEFEICNLAVTfVPDNVPVDEQpANLkelrVNLIKWPNWPDRGVPDEKCht
||.|| . .|.|||. .|  | ||  |.|     ... |... ..  | ..  . .  ||    |.  . . . |    .    | .|||  ||.     
miwqenttaivmlcqfletnrekcaeyfpr....nahcclqfdklsvsyedstvnkslvt.trlnlsyege.trl....ithwlwkewpdwqvpesse..

VPQRLLA--QVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKV-DFEEIITELRK-QRAQCIQTEIQYLYIHRVMIAFARGETDVSE
|  ..|   . |  | |.|||||.||.| ..|.| | . .   . . | ..|.. ||   ||  .||  ||. | .|.. |     ...|
vmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqite
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 54-332 2.2e-45 149.9 In-house 4-277 (287) alignment 
Range on Protein: 54-332
Range on HMM: 4-277/287.0
VETLNNFIIATEKLGIEGLAKQYRKLDA--QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTidkSRYEDYIHANYVKTNYLRNTFICTQGPLQHTII
|| ...|.   .. | ||  .|.  |.   |.. ..| .  .|| .|||..... .|  || |     . .||| | ....   .. || ...|. .|. 
vekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntar

DFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVtETYGCIRVTNMGESSDEfeicnlavTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRG-VPD
.||..| ... . |.|||. .|. . .|  |||.     ..|  ... . |   .         ..  .. | ..  . ....|.  .  ||...| |..
nfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevna........gyierklevknknkagdkqqvkqyqitnWdstgkvte

EKC--HTVPQRLLAQVRH--GPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
 .     . ..  .| ..  .. |||||...||..  .| . . || ..   .|  ... . | |. . .||  || .|  .....
pqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
0041856 (Phosphotyrosine protein) phosphatases II 95-334 2.2e-44 146.5 In-house 1-172 (182) alignment 
Range on Protein: 95-334
Range on HMM: 1-172/182.0
NMHKNRYSDVVCRDTTRvkltidksrYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCktmeegrpkCVGYWPslgvtetygc
|..||||||... | .|         . |||.||..  ..  ..||.|||||..|. ||.||. ...  .|..|.         .. |||          
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

irvtnmgessdefeicnlavtfvpdnvpvdeqpaNLKELRVNLIKWPNWPDRGVPDekcH--TVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNK
                                  .| |  .  ... .||| ||||      ..     .. ..||..||||||.||||..||. . . .
..................................ellerlgiqylylpwpDhgvpd...ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl

ldrglKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
     .|..||.. ..|..| ....|. || ......  . .
.....gvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_egg_pd Subfamily egg 82-340 2.4e-43 143.0 In-house 27-277 (307) alignment 
Range on Protein: 82-340
Range on HMM: 27-277/307.0
QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEgrPKCV
 .. |||  | . |..| |   | |.|..|||| . . .| .|.||||.|| . | |.||..| ||. |  |||||.|||. . |.||  . |    .| 
vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

GYWPSLGV---TETYGCIRVTNMGESSD---EFEICNLAVtFVPDnvpvdeqpanLKELRVNLIKWpNWPDRGvpDekcHTVPQRLLAQVRH--GPCVVH
 |||           | .|..|..  |     | . .| .   .|           .|. ..  .. ..   .  |      | |.| ..|.   | ||.
yywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgd..........deerflehwqg.dvnnss..d...vysplrvlrklrnlskpvvvq

CSAGIGRTGCVVALEFAYNKLDRG--LKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVS
.  |. .....||.| |  .| ||   |    . .  ||..|   ... ..||...|... | |     .
dilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa
subfamily_PTPN23_pd Subfamily PTPN23 70-334 8.2e-43 141.3 In-house 15-281 (288) alignment 
Range on Protein: 70-334
Range on HMM: 15-281/288.0
EGLAKQYRKLDAQQDS---SLTFEAFKQNMHKNRYSDVVCRDTTRVKLTidkSRYEDYIHANYVKTN-YLRNTFICTQGPLQHTIIDFWRMIFQERAESI
 .| |....|. .||    . .  . | . .|||. |..  | .||||    .  .||| | .||       .||.||.||| |. |||.|....... |
taldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssvi

LMLCKTMEEGRPKCVGYWPS-LGVTETYGCIRVTNMGESSDEfeicnlavTFVPDNVPVDEQPANLKeLRVNLIKWPNWPDRGVPD------EKCHTVPQ
 || .  | |.||.  |||.  | |...| ..||   . . |        |.|  .. .. ..|. .   | .... .||. |||.      .  . | .
VmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvrete........thvervlkletldadav.ksvshlqltsWpelGvPasPetllqfldeves

R--LLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLK-VDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
      .  . | |||||||.|||| .  .  | ..|..|   .|  ...  ||.||   .|.. |.     ...  ||
ayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 87-330 8.2e-43 141.5 In-house 40-276 (439) alignment 
Range on Protein: 87-330
Range on HMM: 40-276/439.0
LTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRpkcvgYWPS
 .. | . .  |||| ||.  | ||| |  |    .  || |||.|  |  . .| |||| ..|  ||||.......  |.||.. .|  .     ||||
aslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps

LGVTeTYGCIRVTnmgeSSDEFEICNLAVTFVpdNVpVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVPQ-RLLA----QVRHGPCVVHCSAGIGRT
 . .  || | |        . |. | ..  .  .| ..|.  . ||  |  ...  |||. || .  | .   | .     .   || |||||||.|||
daev.cygdiavr....vdrnielpnyvirgf..kv.fnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrt

GCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
| ..||. | ..|    ||| . |.. ||||| | .|.  ||..|.  ..
Gtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_PTPN14_pd Subfamily PTPN14 82-333 8.3e-43 141.5 In-house 36-296 (300) alignment 
Range on Protein: 82-333
Range on HMM: 36-296/300.0
QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRYEDYIHANYVKTNY--LRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKC
..|. |.  . ..| .|||. ||.  . .||.|.  |   ..|| |  .|.     . ..| .||||..|. |||.|....  . |.|| .. |.|. |.
redallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeks

VGYWPSLG---VTETYGCIRVT-NMGESSDEFEICNLAVTFVPDNvpvdeqpanlKELRVNLIKWPNWPDRGVPDE---------KCHTVPQRLLAQV--
. |.|.|.    | ..|  .|| .. |.|| .    | . ..| .          .|  |  ... .|||.|||..         . . | ..   .|  
fkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk..........eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

--RHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
  .. | .||||||.|||| ..  ..  . |. . ..| ..... ||.||   .||  || ....|.| . 
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 69-350 9.5e-43 141.5 In-house 22-306 (325) alignment 
Range on Protein: 69-350
Range on HMM: 22-306/325.0
IEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERaESILM
 .|.|...  | ...  . .  .  .|. |||. .||  | .|| | | ...   ||| |.|....  ...|. .| || .|| |.||.... |  |...
qdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvv

LCKTMEEGRPKCVGYWPSL-GVTETYGCIRVTNMgeSSDEFeicnlaVTFVPDNVPVdEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVP---------
.   ...|  .|  |||   | . |.| ..|  .  . .|.        .|   . |  |. . . . |.  ..  |.| ||.   .  ..         
vlneldlgkdrcavywpkemgksktfGglevklr..tieei......sdyvhrvldv.kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs

QRLLA-QVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA-RGETDVSEKALAAADAF
.|. |     .| .||||||.||||  ..|  | .|.    .||  . .  |||.| . ..|  ||  |.  .. .   |.|||   .. |  . 
ervtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklss
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 86-329 3.2e-42 139.5 In-house 35-273 (315) alignment 
Range on Protein: 86-329
Range on HMM: 35-273/315.0
SLTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWP
  .    ..|..|||| ...  |..||||  ||.|  .||| | |.|.    ...|..||||. .. |||||..||.. .| |. |  |. . ||  |||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

S-LGVTETYGCIRVTNMGESSDEFEICNLAVTfvpdnvpvdEQPAnlKELRVNLIKWPNWPDRGVPDEKCHTVpqRLLAQVR------HGPCVVHCSAGI
   . .  .| |.|. .  ..|   .    ||          .    .  .|   .. .|||.||. .    .  .|. .|.      . . .||||||.
drkadsvefGsikvellsleadtdgvarklvt.........rkse..esrtvtqfqftewPdkGvdkqtssll..klikevkadngkkefsllvhcsaGv

GRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
|||| |....   ... |.  ||  .....||..| . .||| .| .|. ..
GrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydav
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 83-334 4.8e-42 138.7 In-house 24-278 (287) alignment 
Range on Protein: 83-334
Range on HMM: 24-278/287.0
QDSSLTFEAFK--QNMHKNRYSDVVCRDTTRVKLTIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCV
. |..|| | .   ...||||.||.  | ||| |. .     ||| |||| .    ..||..|||.  |. ||||.....|. |.... . .||.| || 
esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

GYWPSLGVTETYGCIRVTNMGESSDEFEICNLAVTFVpdnvPVDEQPANLkelrVNLIKWPNWPDRGVPDE-----------KCHTVPQRLLAqvRHGPC
 |||   |    |   |. .  .  | | .  |.  .     .. . |..    |. ... .|||....             | |   .|  .    || 
kywPerevPmrvGGysvvlldydikePeygvralrli....dletrearv....vkqldllswPdkvlaPtavglirfvldvkqhielardas..evGPl

VVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
|||...||||.| ..|.    ..|    .||   ..  ||..||  .|. .|. ..   .... .
vvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 74-338 6.3e-42 138.4 In-house 13-272 (283) alignment 
Range on Protein: 74-338
Range on HMM: 13-272/283.0
KQYRKLDAQqDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSryeDYIHANYVK---TNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCK
.....|    | . . .. ..| .|||. ..|  |  ||.|  .     ||| | ..     .   . .| .|.||..|..|||.|.|.|.. .|.|| |
evlkrlsvp.dldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

TMEEGRPKCVGYWPSLGvTETYGCIRVTNMGES-SDEFEICNLAVTFVpdnvpvDEQPANLKELRVNLIKWPNWPDRGVPDEK-CHTVPQRLLAQVRHGP
 .|. | ||  |||. | .| ||   ||   |  |. | | .| .             ..|      .| | .. .  . .        . |  . ..||
lqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvn......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgP

CVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA-RGETD
 |||||.|||||.  .|.  . ...     ||  .... .|.||   .||  ||  .| ...  |  |.|.
ivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 78-340 8.5e-42 138.0 In-house 18-277 (285) alignment 
Range on Protein: 78-340
Range on HMM: 18-277/285.0
KLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLtidKSRYEDYIHANYVKTN-YLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGR
|.        |. |.. |   |||.|| | . ||| |   | .  |||||....     ..|.| |||||  |. |||.||.||.   .||||  .| | 
kikgymppnctytayeanpdlnryadvrcieetrvvl...knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggv

PKCVGYWPS-LGVTETYGCIRVTnMGESSDEfeicNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVP-QRLLAQV--RHGPCVVH
 ||  |.|  ||    .|   .| . |  .|     .| | .     .. . |. . | .| .. | |||.  |..    .   . . .|  .  | .||
ekcalyypeklgevvkfgkyeit.lteckee....aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvh

CSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVS
||||.|||  .| ...|  ..    .... .|. |.|  | |..|. .|.|... |.. .  ||  | 
csagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvve
subfamily_PTPN9_pd Subfamily PTPN9 59-255 3.1e-41 136.3 In-house 5-195 (297) alignment 
Range on Protein: 59-255
Range on HMM: 5-195/297.0
NFIIATEKLGIEGLAKQYRKLDAQQDSSlTFEA--FKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWR
...   .. |..|| |.| .. ... .  ||.|   . |..||||.||.| | |||.|. .|.  . |||.||.|     ...|| |||||..|. ||||
elvayvkekgkrGlskeyaeirnepveG.tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWr

MIFQERAESILMLCKTMEEGRPKCVGYWP-SLGVTETYGCIRVTNMGESS-DEFEICNLAVtfvpDNVPVDEQpanlkeLRVNLIKWPNWPDRGVPDEKC
|......  |.|  ...|.|| ||  ||| . . .. .| ..|.|.   . .....  | .    .||  .|.       .|   .   ||| |||..  
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvlei....knvktees......rkvthfqflsWPdyGvPssaa

HT
  
sl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 70-331 3.1e-41 136.0 In-house 15-291 (301) alignment 
Range on Protein: 70-331
Range on HMM: 15-291/301.0
EGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS---RYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESIL
.....||..|. ..| | | .  ..| . ||. ...  |  |. |.  ..     ..|| |.|..    .. || .|||...|..||||.|.||.  ||.
nkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLCKTMEEGRPKCVGYWPS-LGVTETYGCIRVTNMGES-SDEFEICNLAVTFVpDNVP---VDEQPA---NLKELRVNLIKWPNWPDRGVP---DEKCHT
|.... |. . ||  |||.    .|..| . || . |    .| | .|.|.   |      .  . .   . .   |  ..  .||. ||        . 
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiq.dgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqv

VPQRLLAQ--VRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
. . . .|  .  || |||||....|.|  .... .     .   ||  ...  .|...   ..|  ||  |. |.  
iddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 93-329 1.1e-40 134.3 In-house 41-272 (515) alignment 
Range on Protein: 93-329
Range on HMM: 41-272/515.0
KQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPS-LGVTE
. | .|||| ...  |..||||  |. .  .||. | |...    ...|..|||.. .. ||||...||.   | |. |  |. . ||  |||   | . 
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

TYGCIRVTNMGESSDEFEICNlAVTFVPDNvpvdeqpanlKELRVNLIKWPNWPDRGVPDEKCHTvpQRLLAQVR--H----GPCVVHCSAGIGRTGCVV
 .| |.|  .  ...   |    .| . ..          .   |   .. .|||.||| .       .|. .|.  |     | ..|||||.|||| |.
kfGsikvelvsleactggikr.kltvlkgd..........dsrtvtqfhfteWPdkGvpkhtssl..lklikevkadhgqythpliihcsaGvGrtGvvi

ALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
...    .   .  ||  ...| .|..| . .||. || .|. ..
sidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 72-334 2.2e-40 133.3 In-house 21-277 (312) alignment 
Range on Protein: 72-334
Range on HMM: 21-277/312.0
LAKQYRKLDA-QQDSSLTfeAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRyedYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCK
|.|.|. .    .||  |  || .    ||| .. | |  |  |. |.     |||||.||     . |.||||||. |.  ||.. .   . ||..|| 
ltkeykavgnivsdsect..aflkfkdlnrypniqcwdrgrftlagdenf...yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

TMEEGRPKCVGYWPSLGVTETYGCIRVtnMGESSDEFEICNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDeKCHTVpQRLLAQVRH--GP
 .|.|  ||. |   .         ||    |.  | ||   .   .   |      |  .| ..|  .|  ||| |.||  | |  .|||. |..   |
fvedgsekcakyisdivgfvdledhrv..yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpd.scdta.lrllsavkkdkkp

CVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
 . |||||.|||| .. .|     |    | .  ..   |||.||. ...  ||.|  |... |  
viahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 91-330 4.5e-40 132.6 In-house 46-281 (297) alignment 
Range on Protein: 91-330
Range on HMM: 46-281/297.0
AFKQ-NMHKNRYSDVVCRDTTRVKLTIDKSR-YEDYIHANYVKTNylRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRpKCVGYWPSLGV
| |. |..|.||....  |. |||| |  .    ||. | .||.|  .. .|.|| | . |. |||.|...|..  |.|| .  |. . ||  ||.  ||
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgn..khrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

TEtYGCIRVTNMGESSdefeicnlAVTFVPDNVPVDEQPANLKELrVNLIKWPNWPDRGVPDEKCHTVPQRLLAQVR-------HGPCVVHCSAGIGRTG
|. .| . |. .  |.           |.  .. | .. |  . . |.  .. .|||. |. ..  .  . |. .||       .|| .|||.||.||||
tt.fGdvsvvllsvse........reGfikrelevtkgkakarrv.vkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg

CVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
 .....    .  |  .||  .... ||..| . .||. || ... ...
vlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_PTPN1_pd Subfamily PTPN1 84-327 1e-39 131.0 In-house 21-265 (290) alignment 
Range on Protein: 84-327
Range on HMM: 21-265/290.0
DSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSryeDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYW
| . .   ...|  .||| ||   | .|.||  ..    ||| |. |. . ..  .| ||||| .|.  ||.|...... ...|| | .|... ||. ||
dfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PSLGVTETYG----CIRVTNMG-ESSDEFEICNLAVTFvpdnvpvdeqpANL-KELRVNLIKWPNWPDRGVPDEKCHTVpqRLLAQVR--------HGPC
|.   ...       ..|. .  |..... .  | ..             .  .   .   ..  ||| |||.     .  ..| .||        .|| 
Pqgeeekellledtklkvkliseerksyytvrllelen...........lktqetreilhfhyttwpdfgvpespaafl..kflfkvresGslssdvGpa

VVHCSAGIGRTGCVVALEFAYNKLDRGLK---VDFEEIITELRKQRAQCIQTEIQYLYIHR
|.||||||||.| .. ..    ....  .   || .. . ||||.|   |||  |  . . 
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl
0049772 (Phosphotyrosine protein) phosphatases II 80-332 1.1e-38 129.1 In-house 31-279 (314) alignment 
Range on Protein: 80-332
Range on HMM: 31-279/314.0
DAQQDSSLTFEAFKQNMHKNRYSDVVCRDtTRVKLTIDKSRYEDYIHANYVKTNylrNTFICTQGPLQHTIIDF----------WRMIF--QERAESILM
 . .. ....  .  |..|||| |... | .||.|     .  |||.|.||..    ..||.|||||..|..||          |||..  . .   | |
svlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------LCKTMEEGrpkcvgywpslgvtetygcirvtN----------MgessdefeicnlavtfvpdnvpvDEQ--PANLKELR
                     |.. .. |                       |                                  .|.  |  ...| 
srdevladelsrLdaAlgKtpllildgng.......................neptaadlellk.......................eelydpelferlg

VNLIKWpNWPDRGVPDEKCHTVPQRLLAQ-VRHGPCVVHCSAGIGRTG--CVVALEFAYNkldrglKVDFEEIITELRKQRA-----QCIQTEIQYLYIH
.... . ..|| ..|...      ... .  ..|| .|||.||.||||  .|.|.   ..      .|..||.. ..|..|       .|.. .||..|.
ikylri.pvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll......gvsleealedvrlkRpinpnpgfieqleqyefil

RVMIAF
...  .
ealley
0046846 (Phosphotyrosine protein) phosphatases II 120-331 4e-38 126.3 In-house 10-171 (176) alignment 
Range on Protein: 120-331
Range on HMM: 10-171/176.0
RYEDYIHANYVKTNYlrntFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlgvTETYGCirvtnmgessdefeicnlavtfvpd
 . |||.||.. ...    .|.||||| .|. ||..|..... . ...|.. .| || ||  |||     |..|.                         
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.........................

nvpvdeqpanlkelrvnLIKWPNWPDRGVPDEK--CHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNkldrGLKVDFEEIITELRKQRA-QCI
                  ... .||| |||| .  .. . .   |. ..|| .|||||||||||..||.   .     .  .. ||.. ..|.||  ...
.................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgav

QTEIQYLYIHRVMIA
||. || ......  
qtpeQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 121-326 1.7e-37 124.1 In-house 4-154 (172) alignment 
Range on Protein: 121-326
Range on HMM: 4-154/172.0
YEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTmeegrpkcvgywpslgvtetygcirvtnmgessdefeicnlavtfvpdn
..|||.|.|....|  . ||.|||||..|. |||||. ..    |..|..                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

vpvdEQPANLKELRVNLIKWPNWPDRGVPdEKCHTVP-----QRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYnkldrgLKVDFEEIITELRKQRAQC
    . .. | |  .  . . .||| |||    .        ..|||. ..||..||||||.||||..||.   .      |....||.. ..|..| ..
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpga

IQTEIQYLYIH
.|.. || ...
vqnpsqyrfly
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 94-329 3.1e-37 123.1 In-house 2-235 (237) alignment 
Range on Protein: 94-329
Range on HMM: 2-235/237.0
QNMHKNRYSDVVCRDTTRVKLTIDKSRyEDYIHANYVKT-NYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVTETY
.|  ||||...|. | .|| |    |   ||| |.|.|  .   ...|..||||. .  |||.|..||.   |.||   .|  . ||  ||||    ..|
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GCIRVTNMgeSSDEFEicNLAVTFVpdnvPVDEQpANLKELRV-NLIKWPNWPDRGVPDEKCHTV--PQRLLAQVRH----GPCVVHCSAGIGRTGCVVA
| . |.      .||   . .|  .     . ..  .|||.|.    ..  |||||||.. .  .   .... . .|    || ..|||||.|||| .. 
gvltvslk..kkeefs..dytvrsl....llskr.ltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflv

LEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
..    .      ||  . .  . ..|   |||. ||..||...
idamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0036282 (Phosphotyrosine protein) phosphatases II 122-327 1e-36 121.6 In-house 2-164 (174) alignment 
Range on Protein: 122-327
Range on HMM: 2-164/174.0
EDYIHANYVKTNYLRNTFICTQGPLQhtiidFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlgvtetygcirvtnmgessdefeicnlavtfvpdnv
.|||.|.... .|  . .|..||||.     ||.|..... ....||.. .| |. ||  |||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

pvdeqPANLKELRVNLIKWPNWPDRGVPDE----KCHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDrGLKVDFEEIITELRKQRAQCIQ
       .  |  .  ... .|||.||||     ..    .. |.. ..||..||||||.||||..||.   .  |     ||  ... |||.|| ...|
.....lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvq

TEIQYLYIHR
|. || ... 
tpsQyrflyy
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 96-325 1.7e-35 117.3 In-house 51-273 (301) alignment 
Range on Protein: 96-325
Range on HMM: 51-273/301.0
MHKNRYSDVVCRDTTRVKLTIDKSRYEdyIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLgVTETYGCI
 .|.||  | |. .| |..  |  |    ||||...|.   . ||.|||||. |  ||| |. |   | | ||....|.   ||  | |.  ..|.    
kdkhryptvPckPstavevivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvk.isekldig

RVtNMGESSDEfEICNLAVtfVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDR
|  ..   . |  | |  .  .  .. | .   ...   |   .. .|.|||||  . ..     |..  . | ||||||||||. . .. |.  .... 
rf.kikiknke.lilnkki..skrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarevea

GLKVDFEEIITELRKQRAQCIQTEIQYLYI
  .... | . .||..| . .||. |  ..
dptieltealkhlrehrwngvqtnsqlywm
subfamily_CG7180_pd Subfamily CG7180 92-330 3e-35 116.3 In-house 39-287 (296) alignment 
Range on Protein: 92-330
Range on HMM: 39-287/296.0
FKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRpKCVGYWPSLGvTE
 |.|. |||. .||  | .|| |. .|    .||| | || .    . .| |..| ..|. .|||....| .... .|.||..  . ..  |||  .  |
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.ke

TYGCIRVTNMGE-SSDEFEICNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPD-RGVPDE-----KCHTVPQRLLAQV----RHGPCVVHCSAGIGR
 || | |  . | .  ...| .. .|     .   |.. . ..  | |...  |.    ||       .     . .  .|     .|| ||..| | .|
qygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasR

TGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
.|  .|.. . .....  .||. | .  ||..| | ...  .| ||  |. 
sGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
0049260 (Phosphotyrosine protein) phosphatases II 131-326 9.9e-35 114.8 In-house 3-143 (152) alignment 
Range on Protein: 131-326
Range on HMM: 3-143/152.0
KTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWpslgvtetygcirvtnmgessdefeicnlavtfvpdnvpvdeqpanl
.  .  . ||.||||. .|. |||||. .  .  |.||.. .| |..||  |.                                               
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................

kelrvnLIKWPNWPDRGVPDEKCHTVPQRLL----AQVRHGPCVVHCSAGIGRTGCVVALEFAYnkldrgLKVDFEEIITELRKQRAQCIQTEIQYLYIH
       ... .||| ||||   .     |.    |. ..||..||||||.||||..||.   .      |.|..||..  .|..| . .... |. ...
......qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 87-328 3.9e-34 112.7 In-house 37-231 (392) alignment 
Range on Protein: 87-328
Range on HMM: 37-231/392.0
LTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGrpkcvgywps
 |    . |..|||| ...  |..||||  || .  .||. | |...    ...|..|||   .. |||||.|||.. .| |. |  |            
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

lgvtetygcirvtnmgessdefeicnlavtfvpdnvpvdeqpaN-LKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQVRHG----PCVVHCSAGIGRT
                                           .  .   |   .. .|||..||   .  .      .. .|    | ..|||||.|||
...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrt

GCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRV
| |....    .  .   ||  ...|..|..|   .||. || .|.  
gvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiyga
subfamily_PTPRN_pd Subfamily PTPRN 73-326 1.2e-32 107.8 In-house 32-285 (297) alignment 
Range on Protein: 73-326
Range on HMM: 32-285/297.0
AKQYRKLDAQQDSSLTF--EAFKQNMHKNRYSDVVCRDTTRVKLTIDKSR-YEDYIHANYVKTNYLRN-TFICTQGPLQHTIIDFWRMIFQERAESILML
.|..  | | .    |      ..|..|||...|.  | .||||. . |.  .||| |  .  .  |. ..| ||||| .|. |||.|.... .  |..|
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

CKTMEEGRPKCVGYWPSLGvTETYGCIRVTNMGES--SDEFeicnLAVTFVPDNVPVDEQPAnlkelrVNLIKWPNWPDRGVPDEKCHTVPQRL-LA---
..  |||  .|  |||  | .|.|.   |  . |   .|..    |  .|   |.  .|  .      |   ..  ||..||| .    .  |  .    
trleeegvkqckrywpdeG.sevyhiyevhlvsehiwcddy....lvrsfylknlqtsetrt......vtqfhflswpeegvPasaksllefrrkvnksy

QVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLK-VDFEEIITELRKQRAQCIQTEIQYLYIH
. |  | |||||.| ||||. .....  |.| .|.| .|    .  || ||.. ..|. |. .. 
rGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefal
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 94-329 2.6e-32 106.9 In-house 7-237 (239) alignment 
Range on Protein: 94-329
Range on HMM: 7-237/239.0
QNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTN-YLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlgVTET
 |  ||||...|  | .|| |  . .  . ||| |.|..      ...|.||| .. .  |||||..|||   |.||   .|  . ||  |||    |  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..stsk

YGCIRVTNMgesSDEFEICNLAVTFVPDNVpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQR--LLAQVR--HGPCVVHCSAGIGRTGCVVALE
|  .|||       |     .  |||  .|       . .|  |   ..  |||.|||.     .  |  .  .      | |.|||||.||||... ..
ycnlrvtlr...ktevfadyiirtfvmsqv......gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

FAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
    .  .   ||  . .  .|..| . .||  ||..||  .
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 94-329 2.8e-32 106.8 In-house 6-236 (239) alignment 
Range on Protein: 94-329
Range on HMM: 6-236/239.0
QNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTN-YLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlgVTET
 |  ||||...|  | .|| |  . .  . ||| |.|..      ...|.||| .. .  |||||..|||   |.||   .|  . ||  |||    |  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..stsk

YGCIRVTNMgesSDEFEICNLAVTFVPDNVpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQR--LLAQVR--HGPCVVHCSAGIGRTGCVVALE
|  .|||       |     .  |||  .|       . .|  |   ..  |||.|||.     .  |  .  .      | |.|||||.||||... ..
ycnlrvtlr...ktevfadyiirtfvmsqv......gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

FAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
    .  .   ||  . .  .|..| . .||  ||..||  .
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
0051082 (Phosphotyrosine protein) phosphatases II 121-328 5.6e-31 102.5 In-house 2-148 (151) alignment 
Range on Protein: 121-328
Range on HMM: 2-148/151.0
YEDYIHANYVKTNylrntFICTQGPLQhtiiDFWRMIFQERAESILMLCKTMEEGrpKCVGYWPSLGvtetygcirvtnmgessdefeicnlavtfvpdn
..|||...||  .     .....|||.    ||.... ..   .|..|....| |  .|  |.|.||                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

vpvdeqpanlkeLRVNLIKWPNWPDRGVPD--EKCHTVPQRLLAqVRHGPCVVHCSAGIGRTGCVVALEFAYNKldrglkVDFEEIITELRKQRAQCIQT
            ..|  | ...||| |.|.  . .  . . ||.  ..||..||||||.||||..|||   . .      |..||.. |.|..|  ..|.
............ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp

EIQYLYIHRV
. |.|.....
nqqflfqlfa
subfamily_ptpA1_pd Subfamily ptpA1 69-298 7e-31 102.4 In-house 20-261 (418) alignment 
Range on Protein: 69-298
Range on HMM: 20-261/418.0
IEGLAKQYRKLDAQQDSSLTFEAF-KQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRnTFICTQGPLQHTIIDFWRMIFQERAESIL
|  . ...| |.     | | |   |.|  ||||....  . |||.|  |.     ||| |||.   | .  ||||||||  || |||||....|.  |.
ihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriiv

MLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNmgESSDEFEICNLAVTFVPDNVPVDEQ--PANLKELR-VNLIKWPNWPDRGVPDEK------CHTVP
|| .  |. | ||  |||     | .      |  |    . .  . |   |.   .  .   .   | | .   ..  |||. .||         |.. 
mlsresencrikcdrywpeqiggeqfsiygngn..evfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsit

QR----LLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLK
.|    . .  |  | .||||||.|||| ...     .|||. .|
nrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 51-336 8e-31 101.6 In-house 8-288 (302) alignment 
Range on Protein: 51-336
Range on HMM: 8-288/302.0
RKYVETLNNFIIaTEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKsryEDYIHANYVKTNYLRNTFICTQGPLQHTI
.|.||  ..  . ...|    . |.. |.|... .    .|||.|..||.  || . |...|||.  .   ..|..|  |.   |... | .| | . . 
ekWveeeeakkl.vksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaep...dsyvnaskvevPeltrsiilaQlpkvdse

---IDFWRMIFQERAESILMLCKTMEEGRpKCVGYWP-SLGVTETYGCIRVTNMGESSDEFEICNLAVTFVPDNVpvdeqpANLKELRVNLIKwpNWPDR
    .||||.|||.  |. .| .. |  .     ..|   |  ..|| ..| |   .. | |  ....  .|...      .|     |....  ||.. 
dsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegc......snsvlanvyvlt..nWkqk

GVPDEKCHTVPQRLLA----QVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGE
 ||..  ... .        .    ..|.    |.|| | ...|  | .||..| ..  .||.. .|.||.. ... .||  ...... . . .
kvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 80-251 4.3e-29 96.3 In-house 18-182 (297) alignment 
Range on Protein: 80-251
Range on HMM: 18-182/297.0
DAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDkSRYEDYIHANYVKTN--YLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRP
| ..  |..    .  ..|||| |..  |.|||||       .||| |.||          .|..||||. |. |||......    | |..|  |.|| 
deargesfssakrnsslrknryrdilatddtrvkllrv.iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

KCVGYWPSL-GVTETYGCIRVTNMGESSDEFEICNLavTFVP--DNvpvdeqpanLKELRVNLIKWPNWPDRGVPDE
||. ||||  .   . | . |  . . ||||.   |  | .               ..  |. ... .||| ||| .
kcapywpsvvqerlkagdvvveflsstsdefdrvil..telqliyr.........sesrvvrhvqflswpdhGvpsd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 94-341 2.6e-28 94.0 In-house 18-257 (290) alignment 
Range on Protein: 94-341
Range on HMM: 18-257/290.0
QNMHKNRYSDVVCrDTTRVKLTIDKSRYE-DYIHANYVKT-NYLRntFICTQGPLQHT-------IIDFWRMIFQERAESILMLCKTMEEGRP----KCV
..  ..|..  .    ||| |   ..|.  ||||||.|.  | ||  .| || |....       | .|| |. ||..... |||. .|. .      | 
khemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpnglr..liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

GYWPS-LGVTETYG--CIRVTNMgESSDEFEICNLAVTFvpdnvpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGI
 | |   |   ...   .. ... |  |..|. .| |.|            . .|. |.  .  .| .. |....   .      . .. | .|||  ||
kYvpesvgeelkfkgltvkCksk.ekeddvetRelvvkf...........ddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGi

GRTGCVVALEFAYNKLD-RGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIafargetdvsE
 |  .. |.. .| |.     .| .|... .||||||..|...... ..  ...           
SrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv..........l
PTPc_DSPc_SM00012 235-330 1.4e-27 91.3 In-house 2-104 (105) alignment 
Range on Protein: 235-330
Range on HMM: 2-104/105.0
VNLIKWPNWPDRGVPDEKchTVPQRLLAQVRH--------GPCVVHCSAGIGRTGCVVALEFAYNKLDRG-LKVDFEEIITELRKQRAQCIQTEIQYLYI
|. .....||| |||.|   .   .||..|..        .|.|||||||.||||..|||. ....|...  .||...|. ||||||....||| |||..
vkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

HRVMI
.|...
yrall
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 90-336 2.8e-27 90.4 In-house 28-262 (267) alignment 
Range on Protein: 90-336
Range on HMM: 28-262/267.0
EAFKQNMHKNRYSDVVCRDTTRVKLTidkSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCvgYWPSLGVT
   ..|  .||. |..  | ||| |     . |.|| | ||.. . .|.|| ||.||. || ||. .| ...   | .| |. ..  ..   . | .| .
siaeknqernrlddnlpyddtrvilr...tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlf..wPPkmgqa

ETYGCIRVTNMGE-SSDEFEICNLAVTFVPDNVpVDEQPANLKELRVNLIKWPNWpdrgvpdEKCHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEF
. |  . |    |   ....|  | . |  ..   .      |.  .|  . |         .    .  .   .    | ||.||.|.||.|  . .. 
kkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnintnnkpyl.......kplfgilaknqlengnrPlvvacsdGvGrsGtflvids

AYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGE
  ... .   .|  . . ..|.||   ..|  .|.|||...  .|.| 
qleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegr
0044763 (Phosphotyrosine protein) phosphatases II 119-327 2.5e-26 87.8 In-house 15-165 (178) alignment 
Range on Protein: 119-327
Range on HMM: 15-165/178.0
SRYEDYIHANYVKTNylrnTFICTQGPlqhtiIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVtetygcirvtnmgessdefeicnlavtfvp
  . |||.|...  .     ......|      |..... ..   .|..|....| |..||  |||.                                 
lersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............................

dnvpvdeqpanlkelrvNLIKWPNWPDRGVPDEKCHTVPQRLLAQ----VRHGPCVVHCSAGIGRTGCVVALEFAYNKldrglKVDFEEIITELRKQRAq
                    .. ..|| ||||   |.     . .     ..||..||||||.||.|..||.   .       ....||.| ..|..|  
.................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.

CIQTEIQYLYIHR
..... |. ....
ivpnpgqlrqLye
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 74-327 4.8e-21 69.7 In-house 26-273 (303) alignment 
Range on Protein: 74-327
Range on HMM: 26-273/303.0
KQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTiDKSryedYIHANYVKTNYLRNTfICTQGPLQHTIIDFWRMIFQERAESILMLCKTME
... |. .    |.. . | .||.|||. ||.| | ..|||. | |    ||||.|.. .  ... | || ||.||  |||.|| ...   .|.|    |
nefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls.dss....yihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdse

EGRpkcVGYwpSLGVTETYGCIRVTNMGESSDEFEICNLAVTFVPDNVPVDEqpANLKELrVNLIKWPNWPDRGVPDE-KCHTVPQ-----RLLAQV-RH
  .   .|        .    ..  .      ||   .|.  .|   . | .   . | . . . .. .||   .| .   . | |      .| .    
ydk...lgg..dsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsn..gdyksf.lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysds

GPCVVHCSAGIGRTGCVVALEFAYNKLDRG-LKVDFEEIITELRKQRAQCIQTEIQYLYIHR
 | |    .| ||.|    .| |.  |      .|.   .  .|. | ...|   |. ... 
tptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvyt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 94-222 6.8e-21 69.4 In-house 46-187 (350) alignment 
Range on Protein: 94-222
Range on HMM: 46-187/350.0
QNMHKNRYSDVVCRDTTRVKLT--------IDKS-RYEDYIHANYVKTN----YLRNTF--ICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPK
. . ||||....  . .||||         ...| . .||| |||.| .         |  | ||.||. |. ||...|..   . ||.| . .| .. |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CVGYWPSLGVTETygCIRVTNMGESSDEFEICNLAVTFVPDNVP
|  ||. ... .    ...... |.  . . . | .. |  . .
cyrYWqegsyddi..tvklaskwenimgindsslysadvkkeas
0048076 (Phosphotyrosine protein) phosphatases II 202-328 5.9e-20 66.9 In-house 18-138 (145) alignment 
Range on Protein: 202-328
Range on HMM: 18-138/145.0
ESSDEFEICNLAVTFVPDNvpvdEQPANLKELRVNLIKWPNWPDRGVPDE--KCHTVPQRLLAQVR-HGPCVVHCSAGIGRTGCVVALEFAYNkldrgLK
  .|  ....| .| | .         .| |  .  . . .|||.||||      .. . . . .. .||..||||||.||||..||.   .      |.
taldlellkdlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lg

VDFEEIITELRKQRAQCIQTEIQYLYIHRV
|..||.. ..|.|| ...... |. .....
vsleealelvrsqrpgavpnpgqlrflyef
0048179 (Phosphotyrosine protein) phosphatases II 198-327 1.3e-19 65.8 In-house 14-139 (144) alignment 
Range on Protein: 198-327
Range on HMM: 14-139/144.0
TNMGESSDEFEICNLAVTFVPDNVPvdEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVPQ-----RLLAqvRHGPCVVHCSAGIGRTGCVVALEFAYnk
 ..  ..|  ....| .| | . ..  | . .  |  .  . . .|||.||||   .         ..|.  ..||..||||||.||||..||.   .  
gslptaldlellkklgittvinlte..eyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk..

ldrGLKVDFEEIITELRKQRAQCIQTEIQYLYIHR
    |....||.. ..|..| ...... |. ....
...klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPN9_pd Subfamily PTPN9 261-335 5.1e-19 63.4 In-house 218-292 (297) alignment 
Range on Protein: 261-335
Range on HMM: 218-292/297.0
LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARG
  ...  | ||||||||||||  ..|... ..|..  .||  | .  ||.|||  |||. || . .  .. .|  
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_CG42327_pd Subfamily CG42327 96-254 4.2e-18 60.1 In-house 29-182 (319) alignment 
Range on Protein: 96-254
Range on HMM: 29-182/319.0
MHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTN-YLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPS---LGVTE
  |.|. .||    ||| |  | .   . |..|.||.     .| .|..| .|. .  ||||.... ..  |. |..  | |  .|  |.|.   |  |.
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

TYGCIRVTNM-GESSDEFEICNLAVTfvpdNVpvDEQpanlkELRVNLIKWPNWPDRGVPDEKCH
.|| |.||   .|. |.. |  | .     .|  |..     | |     | .|.. .|| |.  
lyGdilvtlkgrevkdryaistlllk....rv..dke.....esrelthywykwleaevPaeeaa
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 126-333 1.6e-17 58.4 In-house 39-221 (255) alignment 
Range on Protein: 126-333
Range on HMM: 39-221/255.0
HanyvktnylrntfictqgplqhTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPslgvTETYGCIRVTNMGESSDEfE-----ICNLAVTFvpdN
                       |.  |...| | ..| . |||   |||. ||  |.|    .|  .  .....  .. .       .  | .|    .
l......................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfp....lekdeklkladvnvtttk.ssadvvlrtleits...t

vpVDEqpaNLKELRVNLIKWPNWPDRGVPDEKcHTVpQRLLAQVRH-GPCVVHCSAGIGRTGCVVALEFAYNKLDRGL------KVDFEEIITELRKQRA
  . |     |   |.  ..  |...  |..  . . . .|  ||.  . |||||.||||.   |  |..| |. | |      ..|. ....|||..|.
..lge...kkkthtvkhysykGWieknaPela.rei.lnilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrk

QCIQTEIQYLYIHRVMIAFA
. |.| .|  .   ... . 
raihtPlqlafsilmvldlv
subfamily_CG42327_pd Subfamily CG42327 261-334 2.5e-17 57.5 In-house 242-316 (319) alignment 
Range on Protein: 261-334
Range on HMM: 242-316/319.0
LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRG-LKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
  . ..|| ||||| |.|||| |.| ..| ..|.     ||  ...  .|..||. ..|  || .|..|.  .|.
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 144-326 2.9e-17 57.1 In-house 98-281 (302) alignment 
Range on Protein: 144-326
Range on HMM: 98-281/302.0
GPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPS-LGVTETYGCIRVT--NMGESSDEFEICNlavTFVPDNVPVDEQP-ANLKELRVNLIK
 | . |.  .| .| | .   .  ||. .|..  ||  |.   .| . ..|   |.  .. .  .||   .   .|.  .| . ..   . ..  |....
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkk...sfklytveiknekkkkkvkktvdila

WPNWPDRGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIH
.  ||| | |.|  ...      .      .||||||.|||| .||. .  .   .    |. .|.. .|. |   .|.| | .|. 
fsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_hpo-7_pd Subfamily hpo-7 126-333 1.8e-15 51.6 In-house 42-232 (263) alignment 
Range on Protein: 126-333
Range on HMM: 42-232/263.0
HanyvktnylrntfictqgpLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPslgvTETYGCIRVTNMGESSDEFEICNLAVTFVPDNVpVDE
                    |  ||  |...| | ..| . |||   |||. ||  |.|    .|  .  ...|.  .. .     |  | .  .. ..|
l...................lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfP....lekdekqklanvnvcttkvqsdvllktlellst.lge

qPANLKELRVNliKWPNWPDRGVPDEKCHTVpqRLLAQVRH-GPCVVHCSAGIGRTGCVVALEFAYNKLDRGL------KVDFEEIITELRKQRAQCIQT
   ...... .  ..  |...  | .    .  ..|  .|.  . |||||.||||.   .  |..| |. | |      ..|. ....|||..|.. |.|
.Kkkthtvkhy..sykgWiekndpelareil..nilkvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht

EIQYLYIH-----RVMIAFA
 .|  .        |. .||
PmqLafsilmvLdfvlnnfa
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 264-330 2.1e-13 44.8 In-house 226-292 (297) alignment 
Range on Protein: 264-330
Range on HMM: 226-292/297.0
VRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
 |  . .||||||.||.| ||  .   .|| ..   |   |.. ||.|||. .||  |. ... ...
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 236-341 3.5e-13 43.7 In-house 92-203 (440) alignment 
Range on Protein: 236-341
Range on HMM: 92-203/440.0
NLIKWPNWPDRGVPDEKCHTVP-----QRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
.  ..  |||.|||      .      .    ..  || .|||||| |||| ..|..    .  |  ..|   .|  .|..| | .||  || ..| ...
kqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavl

-AFARGETDVSE
 ..  |.| . |
egllcgdtlile
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 80-167 9.8e-13 42.3 In-house 22-115 (347) alignment 
Range on Protein: 80-167
Range on HMM: 22-115/347.0
DAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY------EDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILM
 .   | .|.  ..... |||  ||   |.||| |. .||.       | || | ..| .  .. .| || || .|. |||.|..  .   .. 
anyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 102-221 1.8e-12 41.3 In-house 55-189 (349) alignment 
Range on Protein: 102-221
Range on HMM: 55-189/349.0
SDVVCRDTTRVKL---------------TIDKSRYEDYIHANYVKTNYLR--NTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWP
.|..  . .||||               . | .. .||| |||.|   .   . .|.|| ||  |. ||...|  .. . .| | .  |..  ||  || 
kdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq

SLGVTETygCIRVTNMGESSDEFEICNLAVTFVPDNV
 |  ..    ... |  . . . . . | |  | |. 
elsysni..tvklqnsslyianvqGnslrvstvkdtd
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 138-327 5.9e-12 40.2 In-house 6-198 (199) alignment 
Range on Protein: 138-327
Range on HMM: 6-198/199.0
TFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLG-VTETYGCIRVTNMGE-SSDEFEICNLAVTfvpDNVpvdEQPANLKELrv
 .|.|| ||..|. |||.|...  .  |.|.     .       |||.    |  ||.. ||     .  .. |. | .|   .|.     |   .|.  
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt...nnt...tappstrei..

NLIKWPNWPDRGVPDEK---CHTVPQRLL----AQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLD--RGLKVDFEEIITELRKQRAQCIQTEIQYLYIH
   ..  | ..  |.        |  | .     | .  | .|||| | | ||  |||.      .  .   ||. |.   ||. |   | .  .| .|.
shyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

R
.
q
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 138-327 5.9e-12 40.2 In-house 5-197 (198) alignment 
Range on Protein: 138-327
Range on HMM: 5-197/198.0
TFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLG-VTETYGCIRVTNMGE-SSDEFEICNLAVTfvpDNVpvdEQPANLKELrv
 .|.|| ||..|. |||.|...  .  |.|.     .       |||.    |  ||.. ||     .  .. |. | .|   .|.     |   .|.  
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt...nnt...tappstrei..

NLIKWPNWPDRGVPDEK---CHTVPQRLL----AQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLD--RGLKVDFEEIITELRKQRAQCIQTEIQYLYIH
   ..  | ..  |.        |  | .     | .  | .|||| | | ||  |||.      .  .   ||. |.   ||. |   | .  .| .|.
shyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

R
.
q
subfamily_eak_pd Subfamily eak 78-198 7e-12 39.4 In-house 34-155 (332) alignment 
Range on Protein: 78-198
Range on HMM: 34-155/332.0
KLDAQQD-SSLTFEAFKQNMHKNrYSDVVCRDTTRVKLTIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGR
.|| .|   | .  |  .....|   ..| .|   |.||  .   . || |  .. . . . .| |  . .  .  ||.|...... .|..| . .|.. 
dlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkl

PKCVGYWPSLG-VTETYGCIRVT
 |   |.|  .     .| . |.
eksdkyfpdktreelkfGildve
PTEN_1 200-324 1e-10 36.7 In-house 62-184 (196) alignment 
Range on Protein: 200-324
Range on HMM: 62-184/196.0
MGESSDEFEICNLAVTFVPdnvpvDEQPANLKELRVNLIK--WPNWPDRGVPDEKCHTVPQRLLAQV-R----HGPCVVHCSAGIGRTGCVVALEFAYNK
. .... . ..||.  .        ... .|.| . . ..     ..| |.|.  ..    . ...  .    .. ..||| ||.||.|.|||    | .
nlkedgitlvvnlseeeel.....sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykg

LdrglkVDFEEIITELRKQR-AQCIQTEIQYLY
       ...| .  .|..| . ....  |  .
k.....ltadeAlelvrekRppgapnspsqerl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 84-198 2.4e-10 34.5 In-house 84-194 (244) alignment 
Range on Protein: 84-198
Range on HMM: 84-194/244.0
DSSLTFEAFKQ-NMHKNRYSDVVCRDTTRVKLTiDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFqERAESILMLCKTMEEGRpkcvGY
| |.  .||.  | .||| .  .  |  || |.   |  . || | .|        .| || ||  | .|||.|.. ||   .|..  ..||       |
dpsvmkdafnpnnswknregaglpfdfnrvpls.kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvlgsveeed....ey

WPSLGVTETYGC-IRVT
||     | |   | ||
wpdseplewyeeditvt
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 87-175 5.1e-10 33.3 In-house 26-113 (332) alignment 
Range on Protein: 87-175
Range on HMM: 26-113/332.0
LTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRyEDYIHANYVKTNYLRNTFICTQGPL-QHTIIDFWRMIFqERAESILMLCKTMEEG
 |.. | .||  ||   . | | .||.|. .  . .|.  |..|     ....| .| |. .||   ||||.  ||  |....   ..| 
ntydkflnnmdmnriphlycfdhsrvelapqdgk.ddfynaswvdgyskksayifaqapfndhteyvfwrmvs.erkpsmilvfgdidek
subfamily_PTPDC1_pd Subfamily PTPDC1 261-326 9.1e-10 33.3 In-house 109-169 (182) alignment 
Range on Protein: 261-326
Range on HMM: 109-169/182.0
LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKldrglKVDFEEIITELRKQRAQCIQTEIQYLYIH
   ...|   ||| || |||| ..|  . |.|     ... |. |. .|..|...|||  |   ..
afalqegkvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 136-201 1.2e-09 32.0 In-house 235-297 (440) alignment 
Range on Protein: 136-201
Range on HMM: 235-297/440.0
RNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEgrpKCVGYWPSLGVTETYGCIRVTNMG
.|.||.|| ||. |..||||.. . |  .|.|| .  .     |  |||    . |.| . |   |
knafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkg
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 270-330 7.6e-09 29.9 In-house 2-62 (69) alignment 
Range on Protein: 270-330
Range on HMM: 2-62/69.0
VVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
|||||.| ||||  .|.     ..     ||  . .  .|| |   .  ||.|..||  ..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
0038934 (Phosphotyrosine protein) phosphatases II 230-322 9.7e-09 30.6 In-house 75-166 (194) alignment 
Range on Protein: 230-322
Range on HMM: 75-166/194.0
LKELRVNLIKWPN-----WPDRGVPDEKCHTVPQRLlAQVRHGPCVVHCSAGIGRTGCVVALEFAYNkldrgLKVDFEEIITELRKQRAQCIQTEIQY
.... .  .|.|       |.  . .. .. | . | ..  .| ..||| ||.||||..||    |      |. . || |  .|  |  .|..  ..
fekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 264-332 1.4e-08 28.8 In-house 260-343 (350) alignment 
Range on Protein: 264-332
Range on HMM: 260-343/350.0
VRHGPCVVHCSAGIGRTGCVVALEFAYN-------------KLDRGLKV--DFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
 |  | .||||||.|||| .|.|..  .             |||.  |.    . |. |||||| . .|.  |...|.  .  .
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 270-329 1.3e-07 25.8 In-house 1-60 (69) alignment 
Range on Protein: 270-329
Range on HMM: 1-60/69.0
VVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
|||||.| ||||  .|.     ..     ||  . .  .|| |   .  | .|..||  .
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 81-144 2.6e-07 24.7 In-house 34-95 (95) alignment 
Range on Protein: 81-144
Range on HMM: 34-95/95.0
AQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDksRYEDYIHANYVKTNYLRNTFICTQG
    .. |  . . |. |||. ...  |.||| ||    |  ||| | .|     .| .|..||
mtsgapytvgsseanipknrflnifpydatrvvlttk..rdsdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 116-208 3.2e-07 24.7 In-house 7-93 (130) alignment 
Range on Protein: 116-208
Range on HMM: 7-93/130.0
IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFqERAESILMLCKTMEEGRpkcvGYWPSLGVTETYGCiRVTNMGESSDEFE
... . ..||.|..|      . .. || ||  | .|||.|.. ||   .|..  ..||       |||     | |   ...      |||.
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvlgsveeed....eywpdsePlewyee.diivtltdrdefk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 265-332 2.3e-06 21.2 In-house 264-343 (349) alignment 
Range on Protein: 265-332
Range on HMM: 264-343/349.0
RHGPCVVHCSAGIGRTGCVVALEFAYN----------KLDR-GLKVDF-EEIITELRKQRAQCIQTEIQYLYIHRVMIAF
.  . .|||||| |||| .| |..  .          |..   |. |    |. |||||| . .|   |.  |.  .. .
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLky
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 79-174 4.4e-06 18.4 In-house 13-101 (275) alignment 
Range on Protein: 79-174
Range on HMM: 13-101/275.0
LDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTtrvklTIDKSRYEDYIHANYVKTNYlrNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEE
||  .      | | .| .|||...|.| |       .|.   | ..||| ..| |    |. .| | . |  |. ....    .... |    | 
lddlnlddekierfirngeknrftnvtcfde.....ildrenqeffvhantfrtpy..gnflisqapndstnadhlhllwiynvqtvvclvlpeea
TetR_C_9 Transcriptional regulator, TetR, C-terminal 307-352 8.2e-06 13.1 Pfam-A 7-50 (129) alignment 
Range on Protein: 307-352
Range on HMM: 7-50/129.0
ELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVSEKALAaaDAFLK
 ||.  ...|.|  .| |..|...|  | ...   . .|  | .|.
klrrhlskvidtyfkyPylnrllaalvrdsdeeearria..dkyle