Gene Y48G9A.9 in Caenorhabditis elegans

Synonym: CELE_Y48G9A.9, Y48G9A.9

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf14
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP219_AA protein Get Run
CeleP219_AA_54-334 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 44-353 5.4e-210 690.2 In-house 1-310 (310) alignment
Range on Protein: 44-353
Range on HMM: 1-310/310.0
KKTDDHHRKYVETLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRYEDYIHANYVKTNYLRNTFICTQ
|||||||.||...|.||||||||||||||.||||||||.||||||.||.|..|||||||||||.||.||||.|||||||||||||||||||||.||||.|
kktddhhlkylkalenfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsq

GPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESSDEFEICNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNW
|||||||||||||||||||||||.|||..|||||||||||||||||||||||||||..|||.||||||||||||||||||||||||||||||.|||||||
gplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnw

PDRGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVSEKA
|||||||||||||||||||||||||||||||||..|...||||.....|||||||||.||..|||.|.||.|||||.|||.|.||.|.||||||.|.||.
pdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargetevaeki

LAAADAFLKS
|..|||||||
llladaflks

0040438 (Phosphotyrosine protein) phosphatases II 56-333 3.1e-78 258.5 In-house 4-276 (317) alignment
Range on Protein: 56-333
Range on HMM: 4-276/317.0
TLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSR-YEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFW
 |....    |..  .| .....|. .. .. .. ....|..||||.|... | .||||. ....   |||.|.||.. .|...||.|||||..|. |||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMIFQERAESILMLCKTMEEGRPKCVGYWPSlGVTETYGCIRVTNMGES-SDEFEICNLAVTFVPDNvpvdeqpanlKELRVNLIKWPNWPDRGVPDekC
||..... ..|.||....| ||.||  |||. | | ||| ..||...|   ..... .| |.   |.          ....|. . ...||| |||.   
rmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgds..........esrtvthfhytgWpdhgvpp..s

HTVPQRLLAQVR------HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
..  ...| .||      .||..||||||.||||...|.. ... |... .||.||.. |||.||....||. || ....... . 
pdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

0050432 (Phosphotyrosine protein) phosphatases II 63-333 8.1e-77 253.9 In-house 35-299 (308) alignment
Range on Protein: 63-333
Range on HMM: 35-299/308.0
ATEKLGIEGLAKQYRKLDAQQD-SSLTFEAFKQNMHKNRYSDVVCRDTTRVKLtidkSRYEDYIHANYVKTN--YLRNTFICTQGPLQHTIIDFWRMIFQ
  ..|.. .| .....| ....  . .. ....|..||||.|... | .||||    .   |||.|.||..   .|...||.|||||..|. |||||...
lekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

ERAESILMLCKTMEEGRPKCVGYWPSL--GVTETYGCIRVTNMGESS-DEFEICNLAVTFVPdnvpvdeqpaNLKELRVNLIKWPNWPDRGVPD--EKCH
.. . | ||.|..| ||.||  |||.   | ...|| ..||.. | . |.. . .| .|..           . ....|. . ..|||| |||.  | . 
qnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg..........dgesrtvthfhytnWpdhgvPpspeill

TVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
.  ...  . ..||.|||||||.||||...||. ... |... .||..|..  ||.||....||. |||...|... ..
dflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

DSPc_SM00195 72-333 3.8e-76 251.3 In-house 2-262 (263) alignment
Range on Protein: 72-333
Range on HMM: 2-262/263.0
LAKQYRKLDAQQ-DSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS-RYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLC
| ....||.... ... | ...|.|..||||..... | |||||. ...   .|||.|||.|..  ....|.|||||..|. |||||...|. . |.||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KTMEEGRPKCVGYWPSL-GVTETYGCIRVTNMGESSDE--FEICNLAVTFVPDnvpvdeqpanLKELRVNLIKWPNWPDRGVPD--EKCHTVPQRLLAQV
. .|.|. ||  |||.  | .||.| |.|... . ...  ... .| .|.  .           .. .|. ... ||||.||||  ...  . . .  . 
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..........eetrkvtqyqyknWpdhgvpdstksvlellravkksk

R--HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
.  .||.|||||||.||||..|.......||... |||..||..||||||....||. |||.|........
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 72-333 3.8e-76 251.3 In-house 2-262 (263) alignment
Range on Protein: 72-333
Range on HMM: 2-262/263.0
LAKQYRKLDAQQ-DSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS-RYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLC
| ....||.... ... | ...|.|..||||..... | |||||. ...   .|||.|||.|..  ....|.|||||..|. |||||...|. . |.||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KTMEEGRPKCVGYWPSL-GVTETYGCIRVTNMGESSDE--FEICNLAVTFVPDnvpvdeqpanLKELRVNLIKWPNWPDRGVPD--EKCHTVPQRLLAQV
. .|.|. ||  |||.  | .||.| |.|... . ...  ... .| .|.  .           .. .|. ... ||||.||||  ...  . . .  . 
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..........eetrkvtqyqyknWpdhgvpdstksvlellravkksk

R--HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
.  .||.|||||||.||||..|.......||... |||..||..||||||....||. |||.|........
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0051299 (Phosphotyrosine protein) phosphatases II 54-332 7.5e-76 250.6 In-house 7-285 (288) alignment
Range on Protein: 54-332
Range on HMM: 7-285/288.0
VETLNNFIIATEKLGIEGLAKQYRKLDAQQ-DSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS-RYEDYIHANYVKTNYLRNTFICTQGPLQHTII
|| | ... .. . |. ||......| ... | .|.. ....|..||||||... | .||||.  ..    |||.|.|... .| ..||.|||||..|. 
veellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntve

DFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlGVTETYGCIRVTNMGESSdefeiCNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDE
|||||..... . | ||.|..| || ||  |||. | ..||| |.||.. | .     ..  ....   ...|    . ....|. . ..|||| |||| 
dFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.....lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpds

KCHTVPQRLLAQVR----HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
  . .    |..      .||.|||||||.||||...||. ... |... .||..|..  ||.|| ...||. ||........ .
pellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

0036941 (Phosphotyrosine protein) phosphatases II 76-333 9.9e-75 246.9 In-house 19-277 (297) alignment
Range on Protein: 76-333
Range on HMM: 19-277/297.0
YRKL-DAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLtidKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEE
...| . . . ||.  ....|..||||.|... | |||||   ..   |||.|.||.. .| ..||.|||||..|. |||||..... ..|.||.. .| 
feellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel

GRPKCVGYWPSL-GVTETYGCIRVTNMGESS---DEFEICNLAVTFVPDNvpvdeqpanlKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQV------
||.||  |||.  | . ||| ..||......   |.. . .| ||.. ..          ....|. . ...||| |||.   . .    |..       
grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng..........esrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

RHGPCVVHCSAGIGRTGCVVALEFAYNKLD---RGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
..|| .||||||.||.|...|.. ... |.   .  .||. |.. .||.||....||. ||........ . 
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

0046845 (Phosphotyrosine protein) phosphatases II 72-333 2e-74 245.8 In-house 2-274 (284) alignment
Range on Protein: 72-333
Range on HMM: 2-274/284.0
LAKQYRKLDAQQDS---SLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS--RYEDYIHANYVKTN-----YLRNTFICTQGPLQHTIIDFWRMIFQER
| .....|  .. .   ||.. ....|..||||.|... | .||||.  ..     |||.|.||..      | ...||.|||||..|. |||||.....
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

AESILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESS-DEFEICNLAVTFVPDnvpvdeqpaNLKELRVNLIKWPNWPDRGVPD------EKCH
.. | ||....| || ||  |||. | . ||| ..||.. |   | . . .| .|..           . ....|. . ...|||.|||.      | ..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy.........tgesrtvthfhytswpdhgvppspedlleflr

TVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGL---KVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
.| . | .  ..|| |||||||.||||...||. ... |...    .||..|..  ||.|| ...||. ||........ ..
lvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 62-331 2.6e-73 242.8 In-house 19-302 (307) alignment
Range on Protein: 62-331
Range on HMM: 19-302/307.0
IATEKLGIEGLAKQYRKLDAQQD---SSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS--RYEDYIHANYV--------KTNYLRNTFICTQGPLQH
  . . ...||.|...||  ...    . .. ....|..||||.|... | |||||.  ..     |||.|.||        .. .| ..||.|||||..
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESS-DEFEICNLAVTFVpdnvpvdeqPANLKELRVNLIKWPNWPDRG
|. |||||..... . |.||....| ||.||. |||. | . ||| ..||...|.  |.. . .| ||             . ....|. . ...||| |
tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.........dgtgesrtvthfhytgwpdhg

VPDEKCHTVPQRLLAQV------RHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLK---VDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
||.   ...    ...       ..||..||||||.||||...|.  ..  |... .   ||..|.. .||.|| ...|.. || ....... 
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

0039614 (Phosphotyrosine protein) phosphatases II 43-331 3.2e-73 242.1 In-house 5-287 (297) alignment
Range on Protein: 43-331
Range on HMM: 5-287/297.0
YKKTDDHHRKYVETLNNFIIATEKLGIEGLAKQYRKLDAQQDSsLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS--RYEDYIHANYVKTNYL-RNTF
.... ..  .... |. ..  . .... .| ... .|  ....  .. ....|..||||.|... | .||||.  ..     |||.|.||.. .|  ..|
rdallesipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

ICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRpKCVGYWPSLGVteTYGCIRVTNMGES-SDEFEICNLAVTFvpDNvpvdeqpanlKELRVNLI
|.|||||..|. |||||..... ..|.||.|..| || ||. |||. |   ||| ..||....   | . . .| ||   ..          ... |. .
IatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ng..........esrtvthf

KWPNWPDRGVPDEKCHTVPQRLLAQV------RHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
 ...||| |||.   .      |..       ..||..||||||.||||...|.  ... |... .||..|.. |||.|| ...||. || ....... 
qytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle

0043336 (Phosphotyrosine protein) phosphatases II 55-331 6.5e-73 240.9 In-house 5-275 (278) alignment
Range on Protein: 55-331
Range on HMM: 5-275/278.0
ETLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIIDF
..| ....   . .  .| ... .|. ..  . .. ....|..||||.|... | .||||. .....  |||.|.||..    ..||.|||||..|. ||
kdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedF

WRMIFQERAESILMLCKTMEEGRPKCVGYWPslGVTETYGCIRVTNMGES-SDEFEICNLAVTFVPDNvpvdeqpanlKELRVNLIKWPNWPDRGVPDek
|||..... ..|.||.. .| ||.||. |||  | ..||| ..||...|   | . . .| ||   |.          ... |. . ...||| |||.  
wrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdg..........esrtvthyhylgwpdhgvpe..

CHTVPQRLLAQ------VRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
  .  ...| .       ..|| .||||||.||||...||. ... |.....||.||.. |||.||....||. || ....... 
slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

0047943 (Phosphotyrosine protein) phosphatases II 64-332 4.1e-72 238.2 In-house 6-271 (273) alignment
Range on Protein: 64-332
Range on HMM: 6-271/273.0
TEKLGIEGLAKQYRKLDAQQD-SSLTFEAFKQNMHKNRYSDVVCRDTTRVKLtidKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERA
...||. .|......|  ...  . .. ....|..||||.|... | .||||   ..   |||.|.||.. .| ..||.|||||..|. |||||......
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

ESILMLCKTMEEGRPKCVGYWPSLGV--TETYGCIRVTNMGESS-DEFEICNLAVTFVPdnvpvdeqpaNLKELRVNLIKWPNWPDRGVPDEKCHTVPQR
. | ||....| ||.||  |||. |   ..||| ..||...| . | . . .| .|..           . ... |. . ...||| |||.   . .   
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg..........tgesrtvthfhytgwpdhgvppslesllefi

LLAQV------RHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
 |..       ..|| |||||||.||||...||. ... | .. .||..|..  ||.||  ..||. ||........ .
elvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

Y_phosphatase Protein-tyrosine phosphatase 95-330 6.4e-68 224.0 Pfam-A 1-234 (235) alignment
Range on Protein: 95-330
Range on HMM: 1-234/235.0
NMHKNRYSDVVCRDTTRVKLTIDKSRyEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWP-SLGVTETYG
|..||||.|... | |||||. .... .|||.|||||.    ..||.|||||..|| |||||..||. ..| ||.. .|.|| ||  ||| . . ..|||
nkkknRykdilpydktrvklkgsegp.sdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

CIRVTNM-GES--SDEFEICNLAVTFVPDNVpvdeqpanlKELRVNLIKWPNWPDRGVPDEKCHTV--PQRLLAQV--RHGPCVVHCSAGIGRTGCVVAL
 |.|...  |.  ..|. . .| ..   ..          .. .|. . . ||||.|||... . .   ...  .   ..||.|||||||.||||..|||
dikvelkekekedekeytlrklelkkkkees.........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

EFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
... ..|... .||  .|. ||||||....|.. || .......
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 95-330 6.4e-68 224.0 In-house 1-234 (235) alignment
Range on Protein: 95-330
Range on HMM: 1-234/235.0
NMHKNRYSDVVCRDTTRVKLTIDKSRyEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWP-SLGVTETYG
|..||||.|... | |||||. .... .|||.|||||.    ..||.|||||..|| |||||..||. ..| ||.. .|.|| ||  ||| . . ..|||
nkkknRykdilpydktrvklkgsegp.sdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

CIRVTNM-GES--SDEFEICNLAVTFVPDNVpvdeqpanlKELRVNLIKWPNWPDRGVPDEKCHTV--PQRLLAQV--RHGPCVVHCSAGIGRTGCVVAL
 |.|...  |.  ..|. . .| ..   ..          .. .|. . . ||||.|||... . .   ...  .   ..||.|||||||.||||..|||
dikvelkekekedekeytlrklelkkkkees.........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfval

EFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
... ..|... .||  .|. ||||||....|.. || .......
dilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0045098 (Phosphotyrosine protein) phosphatases II 77-331 8.1e-68 224.1 In-house 15-270 (278) alignment
Range on Protein: 77-331
Range on HMM: 15-270/278.0
RKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKltidksryeDYIHANYVKTNylRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGR
..|   . |. |.  .  |..||||.|... | .|||         |||.|.|...   ...||.|||||..|. |||||..... ..|.||.. .| ||
fllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

PKCVGYWPSlGVTETYGCIRVTNMGESSDefeicNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQV------------
 ||. |||. | ..||| ..||.. |.       .  .. .   . .  ....|... |. .....||| |||..  ..  ..|| ..            
ekcaqywpe.ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------RHGPCVVHCSAGIGRTGCVVALEFAYNKLdrGLKVDFEEIITELRKQRAQ-CIQTEIQYLYIHRVMIA
       ..||..||||||.||||..||.   .  |  . .||..|...|||.|| . ..|.. || ....... 
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyeflle

subfamily_PTPRD_pd Subfamily PTPRD 55-353 1.1e-67 224.0 In-house 8-302 (564) alignment
Range on Protein: 55-353
Range on HMM: 8-302/564.0
ETLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDF
..|....   .. .   . ..|.|.. .| .. .  . ..| .||||...|  |..||.| ....    ||| |.....   |...| |||||..|| ||
aelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedF

WRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGvTETYGCIRVTNMGE-SSDEFEICNLAVtFVPDnvpvdeqpaNLKELRVNLIKWPNWPDRGVPDEK
|||..... ..| || |. |.|. ||  |||. | ||||| . || . |    ..||... .    .         . .   |.  .. .|||.|||.. 
WRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkk.........ssesreVrqFhFtsWPdhgvpesa

CHTVP----QRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI-AFARGETDVSEKALAAA
.. .      | |..  .|| |||||||.||||. ....   ...    .||  .....|||||   .||| || .||...  | | |.|.|. ..| ..
tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqh

DAFLKS
   |..
lqkLae

0040439 (Phosphotyrosine protein) phosphatases II 88-330 1.6e-67 223.0 In-house 4-243 (249) alignment
Range on Protein: 88-330
Range on HMM: 4-243/249.0
TFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSl
..  .. |..||||.|... | .||||.| ....  |||.|.|... |  ..||.|||||..|. |||||..... ..|.||....| || ||  |||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

GVTETYGCIRVTNMGESS-DEFEICNLAVTFVpdnvpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQV------RHGPCVVHCSAGIGR
| . .|| ..||.. . . |.. . .| .|..           . ....|. | ...||| |||.   ...    ...       ..||..||||||.||
ggsleygdftvtllsvevkddytvrtleltnl..........ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgR

TGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
||...|.  ... |.. |.||.||.. .||.|| ...|.. || .......
tGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 60-332 2.1e-66 219.0 In-house 6-276 (307) alignment
Range on Protein: 60-332
Range on HMM: 6-276/307.0
FIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSrYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQ
..  | . |.. |  ..|.|  ..  ..| |||. | .||||.|| |.| .|. ...|     |||||||. .    . |||.||||. |. .|| |. |
wvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiq

ERAESILMLCKTMEEGRPKCVGYWPSL-GVTETYgcirvtnmGESSDEFEICNLAV-TFVPDNVPVD----EQPANLKELRVNLIKWPNWPDRGVPDEKC
|. ||..||||..| .. ||  |||   | . ..        ||...   . || . .. ||.  ..    .     |   .. ..| ||||||||. . 
ekvesvimlckvielakikceqywpleegqklvf........geapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinl

HTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLK-VDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
 ..      .  . | |||||||.||.| .||. .  .|. .|    | .... |||.||  .||||.||||.|||.. .
tainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

0042113 (Phosphotyrosine protein) phosphatases II 89-330 5e-66 217.9 In-house 3-240 (245) alignment
Range on Protein: 89-330
Range on HMM: 3-240/245.0
FEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlG
. ... |..||||||... | |||||. |....  |||.|.||.. .  ..||.|||||..|. |||||..... ..|.||....| ||.||  |||. |
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

VTETYGCIRVTNMGESSdEFEICNLAVTFVPDnvpvdeqpANLKELRVNLIKWPNWPDRGVPD-----EKCHTVPQRLLAQVRHGPCVVHCSAGIGRTGC
 . ||| ..||...| . . ...   .. ...         . ... |. . . .||| ||||     ....   .. ||. ..||..||||||.||||.
esltygdftvtllseeh.lddytvrtlevtnl........gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

VVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
..|.  ... |.. |.|..||.. |||.|| ...||. || .......
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 60-350 1.4e-63 209.4 In-house 12-304 (305) alignment
Range on Protein: 60-350
Range on HMM: 12-304/305.0
FIIATEKLGIEGLAKQYRKLDAQQDSSlTFEAFK--QNMHKNRYSDVVCRDTTRVKLtiDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMI
|.  | . | .|| ...  .   .|    ..|||  |. .|||| || | |  ||||  . .   .||||||| |    . ||||| ||..|  ||| | 
fvkrtlekgpaglraefvamkrfndfe.kmkafkeaqeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymc

FQERAESILMLCKTMEEGRPKCVGYWPSLGVTE---TYGCIRVTNMGESSDEFEICNLAVTFVPDNVPVDEQPANlKELRVNLIKWPNWPDRGVPDEKCH
.|.. |.|.|||. .| |  ||. |..|    .     .  ...   ||| .... . | . | . | | | | . | ..|.  .| .|||||||     
lqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpge.karkvthyhwidwpdrgvpaadla

TVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVD-FEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVSEKALAAADAF
 .     |.. .|| |||||||||||| || ||.  ..|  | ...  . |.  .|.|| . |||. |||..|.|.. . | .  . |.  .| .||
ilellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkeaykaf

subfamily_PTPRB_pd Subfamily PTPRB 70-336 8.1e-63 207.2 In-house 25-288 (293) alignment
Range on Protein: 70-336
Range on HMM: 25-288/293.0
EGLAKQYRKLDAQ-QDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILM
 .....| .| |  .| . ..   ..|  ||||....  |..|||| ...... .||| |||.. .  .. || ||||| .|. |||||....... |.|
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGES-SDEFEICNLAVTFvpdnvpvdeqpaNLKELRVNLIKWPNWPDRGVPDEKC------HTVPQRL
| ...|.|. ||  |||.   . .|| |.|| . |.  ... | .|...             . .| .|.  ..  ||| |||..        .|| ...
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek............ekeerkvrqyhftsWpdhgvPektktlldfvrtvreai

LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGE
  . ...| |||||||.||||  .||.   .....   ||   |..|||..|.. .||| ||..||...... | .
ektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 58-333 2.1e-60 198.9 In-house 12-289 (305) alignment
Range on Protein: 58-333
Range on HMM: 12-289/305.0
NNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQ------NMHKNRYSDVVCRDTTRVKLtiDKSRYEDYIHANYVKTNYLRN-TFICTQGPLQHTI
..|.. .  .|.. | ...|.|       .|  ||.       .. ||||.|| |.| . |||  ||    ||||||||    . .  |||.||||..||
eqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl..dkpspsdyihanyvgcpmipekrficaqgpldqti

IDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSL-GVT-ETYGCIRVTNMGESSDEFEICNLAVTFVpdNVPV-DEqpanlKELRVNLIKWPNWPDRG
 .|| |. |.. | |.|||||.| |. ||  |||   |   |  . | | |.  |       .. .| .  |.    .     ... |  ..| .|||||
defwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitll..nltysgd.....qkmsvrhlqwtewpdrg

VPDekCHTVPQRLLAQVRH--GPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKV-DFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
||   |.     ||. .|    | |||||||||||| .||.|.  .|.    ..  . |..  || |||  ||...|||.|||||. . 
vpp..ckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 62-335 1.7e-58 193.0 In-house 13-283 (288) alignment
Range on Protein: 62-335
Range on HMM: 13-283/288.0
IATEKLGIEGLAKQYRKL-DAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTI-DKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQ
. ... . .|. ..|..|   ....| |     .| .|||| ...  | .||||.  .. . .||| |.|.. .  ....|.|||||..|. |||.....
akksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

ERAESILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESSDEfEICNLAVTFVpdnvpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQR
.... |.|| . .|.|. ||  |||. .  . || . || ...   | .. .  .  .           . .||...  ..  ||| |||. |   .  .
nktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskele.dfvlrkllle..........kkkteleitqyqylaWpdhgvPeskapllell

LLAQVR----HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA--RG
   .|      || .||||||.||||  .||. . .....  ..|  .....||||||. .||. || .|..|..  .  .|
rqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg

0037934 (Phosphotyrosine protein) phosphatases II 91-330 2e-58 193.2 In-house 6-239 (243) alignment
Range on Protein: 91-330
Range on HMM: 6-239/243.0
AFKQNMHKNRYSDVVCRDTTRVKLtidKSryEDYIHANYVKTNylrNTFICTQGPLQHTIID----FWRMIFQERAESILMLCKTMEEGRPKCVGYWPsl
 ...|..||||||... | .||||   ..  .|||.||...     ...|.|||||..|. |    ||||..... ..|.||....| || ||. |||  
llpenlsknrysdilpydhsrvkl...eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

GVTeTYGCIRVTNMGESSD-EFEICNLAVTFVP-DNVPvdeqpanlkeLRVNLIKWPNWPDRGVPDE--KCHTVPQR----------LLAQVRHGPCVVH
| . ||| ..||...|..  .. . .| .. .. |...          . |  . . .||| ||||.   .    .           |||  ..||..||
gev.tygdftvtllseehlddytvrtlllenldlddlt..........rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVH

CSAGIGRTGCVVALEFAYNKLdrglKVDFEEIITELRKQRAQ-CIQTEIQYLYIHRVMI
||||.||||...|.   . .|    .||.||.. .||.|| . ..||. || .......
CsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_PTPN6_pd Subfamily PTPN6 54-339 4.4e-58 191.7 In-house 13-303 (306) alignment
Range on Protein: 54-339
Range on HMM: 13-303/306.0
VETLNNfiiATEKLGIEGLAKQYRKL---DAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRYEDYIHANYVKTN--YLRNTFICTQGPLQH
|. |..    .|.|. .|. ... .|   .|..  | .  | ..|..||||  ..  | |||.|. ..   .||| |||.|..    ....| ||| |..
vselek...eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclet

TIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESS-DEFEICNLAVTFVpdnvpvdeqPANLKELRVNLIKWPNWPDRG
|. |||||..|| .. |.|. | .| |. ||. |||.   .|.|| |.|||. |.| ..... .| |. .           . .| .|   .. .||| |
tvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk.........kkkkeerevfqyhfksWPdhg

VPDEKCHT------VPQRLLA--QVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDR-G--LKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGE
|| .. .       | ..     . ..|| |||||||||||| .. ..   ... . |   ..| ....  .|.|| . .||| || ...... .. . .
vpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk

TDV
...
kkl

subfamily_PTPN12_pd Subfamily PTPN12 78-337 4.7e-58 191.4 In-house 23-281 (290) alignment
Range on Protein: 78-337
Range on HMM: 23-281/290.0
KLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGR
|. |..  | .    ..|..|||| |..  |..||.|. ...   .||| ||..|  . . ..| .|||| .|. ||||||.. . | ..|.|. .| |.
kykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk

PKCVGYWPSLGVTET-YGCIRVTNMGESS--DEFEICNLAVTFVpdnvpvdeqpanLKELRVNLIKWPNWPDRGVPDEKCHTVP----QRLLAQVRHGPC
 ||  |||. | .|. .| ..||.. |    |.| |  |.|..              .. .|. ... .|||.|||  . . .      | | .  . | 
kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq............kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPl

VVHCSAGIGRTGCVVALEFAYNKLDRGLK---VDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGET
|||||||.|||| ..|...... | ..     .|  ....|||||||  .||. || .... .. . . | 
vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkel

subfamily_PTPRG_pd Subfamily PTPRG 59-346 2.3e-57 189.5 In-house 8-301 (563) alignment
Range on Protein: 59-346
Range on HMM: 8-301/563.0
NFIIATEKLGIEGLAKQYRKLDAQQD---SSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTID--KSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDF
. ...    |  |..... .|  .        ..   ..| .||||...|  | .||||.    | .  ||| |||..  .  . || |||||..|. ||
khvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddF

WRMIFQERAESILMLCKTMEEGRPKCVGYWPSlGVTETYGCIRVTNMGEssdEFEICNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKC
||||...... | |. .  |.|| ||  |||.   .|||| ..|| . |   |  ..    |.|  |. ....    .|..|   ....||| |||. . 
WrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtliee...evlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl

HT---VPQRLLAQVR-HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA-FARGETDVSEKALAA
     | ..  |. .  || |||||||.||||  ..|.   ... .  .|.  ...  .| ||   .||| ||...| ...   | .||..... . .
pvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 56-346 2.9e-57 189.1 In-house 6-294 (318) alignment
Range on Protein: 56-346
Range on HMM: 6-294/318.0
TLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQ-NMHKNRYSDVVCRDTTRVKLTIDKS-RYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDF
 |.. .   .. |   | ..| .|. ..... .... .. | .|||| ...  |.|||||.  ..    ||| |||.  .  ....| .|.|| .|| ||
dleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDf

WRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGvTETYGCIRVTNMgessDEFEICNLAVTfvpdNVPVDEQPANlKELRVNLIKWPNWPDRGVPDEKC
|||...  .  |.|| ...|.|. |.  |||| | ...|| ..|. .    .|.|. .. .     .. | ..  . ..  |   .. .|||.|||.. .
WrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelk....eevelsdyvlr....efkvtrteee.esrqvrqyhytsWpdegvpesga

HTVP-----QRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA-FARGETDVSEKALAA
. .      ..  ..  .|| |||||||.||||  .|..   ...     ||  .....||.||   .||| || .|. |..   | |.|.|. . |..
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrs

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 49-333 3e-57 188.5 In-house 6-283 (290) alignment
Range on Protein: 49-333
Range on HMM: 6-283/290.0
HHRKYVETLNNFIIATEKLGIEGLAKQYR-KLDAQ-QDSSLTFEAFKQNM--HKNRYSDVVCRDTTRVKLTidKSRYEDYIHANYVKTnyLRNTFICTQG
.|   .|....|   . | ....|||.|  ||        |  . | .|   .|||| |||| | ||| |        ||.||||||   |. .|| |||
rhsvqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk..dGydGdyvhanyvkG..lkamfiltqG

PLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPS-LGVTETYGCIRVTNMGESSDEFEICNLAVTFVpDNvpvdeqpANLKELRVNLIKWPNW
.|. |.||.|||. ||..  | |||. .|.|..||  |.|   | . |.| | |.   |.... .|    ..   |         . || ... .|   |
alkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvr.dk.......dsGkehklkhlkiksw

PDRGVPDEKCHTVpqRLLAQVR--HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
||. |.  .   .  |.|  .|   || ||||||||||||  ||.| . . |  | ..|  ...  ||. |.. .| .|||| . .... . 
pdksvalstlall..rtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlG

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 66-330 1e-56 187.1 In-house 11-273 (281) alignment
Range on Protein: 66-330
Range on HMM: 11-273/281.0
KLGIEGLAKQYRKLDA-QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAE
.   .|....|.|| | ..|.. |    ..|..|||||..|  | ||||.|  ...   ||| ||.|..    . .| ||||. ... .||.|.......
qndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

SILMLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGESSDEfeicnlavTFVPDNVPVdEQpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLA-
 | |. . .|.|. ||  |||    . .|| ..|... |.. .        |..  .. . |.  . .. .|. ... .||| |||..  . .  |    
aivmvtreieagklkChrYWPddnselkygdvtvkstaeeeka........tyierkfkl.er.esgetreveqlaytaWPdhGvPattkellefrkevl

--QVR--HGPCVVHCSAGIGRTGCVVALEFAYNKLDRG-LKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
  . .  . | |.|||||.||||. .||. . .....   ..| .....||||.|   .|| .|| .......
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 91-334 1.9e-56 186.2 In-house 24-269 (274) alignment
Range on Protein: 91-334
Range on HMM: 24-269/274.0
AFKQNMHKNRYSDVVCRDTTRVKLTIDKSRYE--DYIHANYVKT-NYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLG
    . .|||| ...  ...|| |. ..|. |  .|| |||.|  ..  .... |||||..|. ||||||.||... |.|| |  |. . ||. |.|   
dvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

---VTETYGCIRVTNMGE-SSDEFEICNLAVTFVPDNVPvdeqpanlkelrVNLIKWPNWPDRGVPDEK------CHTVPQ-RLLAQVRHGPCVVHCSAG
   ..|.|| . ... .  . ..... .| .  . ..              |  . ...|||. .||.       .. | . |  .. . .| |||||||
dyeiserygdveikvekiverndysvrklvlkylerers............vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaG

IGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
|||||| .| . | ..|..  .||  .|...|| .|   .||. || .|||... ...
iGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 51-332 2.5e-56 186.1 In-house 8-289 (298) alignment
Range on Protein: 51-332
Range on HMM: 8-289/298.0
RKYVETLNNFIIATEKLGIEGLAKQYRKLDAQQD----SSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTI-DKSRYEDYIHANYVKTNYLRNTFICTQGP
... ..|...   ..| .. |.|.....|.. ..     . .    ..| .||||.|..  | .|| |.  |.    ||| | ....   ||.|| ||.|
edlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaP

LQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGvTETYGCIRVTNMGES-SDEFEICNLAVTfvpdnvpvdEQPANlKELRVNLIKWPNWP
|..|. |||||. .| ...| || .. | .. |.  |||. | .|||| |.|. . .    ......|.|.         ..  . || .|  ... .||
ltetvedFWrmvteedigtiVmltnleeldktkyhkywPdeg.ketygeitvsllskeefadlivrklkvs.........kkkee.kerevrqlhftsWp

DRGVPDEKCHTVPQRL---LAQVRHG--PCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
|.||| ...  .  .      | . |  | .|.||||.||.|  .|..   ... .  .||  ...  |||.|.. .||| || .|. ... .
dkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea

subfamily_PTPN3_pd Subfamily PTPN3 75-331 3.5e-56 185.2 In-house 20-273 (280) alignment
Range on Protein: 75-331
Range on HMM: 20-273/280.0
QYRKLDA-QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSryeDYIHANYVKTNY----LRNTFICTQGPLQHTIIDFWRMIFQERAESILMLC
|. .|   ... ...     .|..|||| |..  |.|||||.  ..   ||| ||||. .     | | .| |||||..|  |||.|....... |.|| 
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlt

KTMEEGRPKCVGYWPSLGVTETYGCIRVTNMGEssdefeicNLAVTFVPDNVPVDEQPANlKELRVNLIKWPNWPDRGVPDEKCHTVP----QRLLAQVR
 ..|.|| ||  |||. . . .||...|.   |        .   ..|  .. . .. .. .| ..  ... .||| ||||.. . .      | | ...
tlverGrvkChqyWPetedeleygefsvkceke........detksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgk

HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
. | |||||||||||| ...|| |  ....  .|   .|. ..| |||  .||. || ..   ...
eePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 54-339 6.1e-55 181.5 In-house 6-290 (305) alignment
Range on Protein: 54-339
Range on HMM: 6-290/305.0
VETLNNFIIATEKLGIEGLAKQYRKLDAQqDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIID
...|...|  ...   .|| .||..|  . ..|.  .  ..| .|||.....  |. |..|| ..|   .||| |.||..   ....| .||||..|. |
lddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvad

FWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLG-VTETYGCIRVTNMG-ESSDEFEICNLAVTFVPDnvpvdeqpaNLKELRVNLIKWPNWPDRGVPD
|||.|..|. ..|.||.|..|.|. ||  |||     .. .| . |.    ..  .. . .| ...  .         . ..  |   .  .||| |||.
fWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.........dkesrtvlqyqltdWPdhGvpq

EKCH--TVPQRLLAQVRHG---PCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR-GETDV
.     .. .|.  . ...   | .||||||.||||  .|.. | ..| .   ||. |.. .||..| . .||  || ..| ..      |.|..
fatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsi

subfamily_PTPRA_pd Subfamily PTPRA 76-342 3.3e-54 179.0 In-house 38-305 (330) alignment
Range on Protein: 76-342
Range on HMM: 38-305/330.0
YRKLDA-QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTID-KSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTME
.  | | . ...|   . ..|..|||. ...  | .|| |.      . ||| | ...    ...|| .|||...|. ||||||.. .. .|.|| .  |
fnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelke

EGRPKCVGYWPSLGVTeTYGCIRVTN-MGESSDEFEICNLAVTFVPDNVPVDeqpanlKELRVNLIKWPNWPDRGVPDEKCHTVP----QRLLAQVRHGP
  . ||  |||. |.  ||| |||.    . . .. . .. |. .||.   .      |.  |. ...  ||| ||| |    .      . | |.  ||
rkeekcaqywPdeGlv.tyGnirvevedetvlvdytvrkflvqqlpdatrek......ksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagp

CVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF-ARGETDVSEK
 |||||||.||||  ..|.   ...    |||  |.. .||.||.| .||. || .|..|.  .   |.|..   
ivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvs

subfamily_Ptp69D_pd Subfamily Ptp69D 57-345 5.4e-54 178.4 In-house 9-299 (307) alignment
Range on Protein: 57-345
Range on HMM: 9-299/307.0
LNNFIIATEKLGIEGLAKQYRKLD-AQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFW
|.. . . ..   .|||| |.||   . | | .. . | |  |||| |..  | |||||. |  . . ||| |...|.   ...||. |.|.. || |||
leealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfW

RMIFQERAESILMLCKTMEEGRPKCVGYWPSLgVTETYGCIRVTNMGE-SSDEFEICNLAVTFVPDNVPVDeqpanLKELRVNLIKWPNWPDRGVPdEKC
||| .   . | || .  |  | ||  |||    .  || | |. . | . ... | .| |. . ....        .. .|   .. .|.|  || | .
RmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgev.....edsrkvvqyhytgWkDskvP.eva

HTVP---QRL--LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR-GETDVSEKALA
...    ...  | .  ..| ||||||| ||.| .|||.   ..|    |||  |.. .||.||   .|   || ...| .. .   |.||.. . |.
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddle

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 76-334 4.5e-53 175.0 In-house 1-265 (270) alignment
Range on Protein: 76-334
Range on HMM: 1-265/270.0
YRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVK-TNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTME
...|| .. |. .. .. .. . ||| |..   .|||.|  ...     || ||||.  .  ....|...|||. |. .|||||..|....|.|. . .|
fkeldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleE

EGRPKCVGYWPSLG---VTETYGCIRVTNMGESSDEFeicnlavtFVPDNVPVDEQPanlKELRVNLIKWPNWPDRGVPDEKC-HTVPQRLL---AQV--
.|| ||  |||.     |. ..| |.|... |. .|.        ..  .. . |.    .| |.    . .|||.||| |.   . .. ||   ..|  
kgrkkCerYWpaepkekvkledgkikvlalseekeeg........yiltrlrleekg...eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrr

------RHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
      . .|..||||||.||||...||..| . |..  |||  .||.||||.| ...|.  || ....... .|.
sekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 54-340 6.7e-53 174.8 In-house 7-291 (319) alignment
Range on Protein: 54-340
Range on HMM: 7-291/319.0
VETLNNFIIATEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIID
|. |.. . | .. |  .|.|....|.  .. ...    ..| .||||....  | |||.|. .| .   ||| |... .   |. || ||.||..|| |
vqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentied

FWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGvTETYGCIRVTNM-GESSDEFEICNLAVTFVPDNVPVdeqpanlkeLRVNLIKWPNWPDRGVPDE
||||...|..  ..||.|  |... |.  |||.    |.|| . ||    |  ....| .| .    ..|            .|   .. .||| .||..
fWrmvWeeessivvmltklveklkvklkkywpeen.feeyGrlivtleeeeeledyiirklklnkkssevet.........RevkhfqyteWpdhdvPek

KCHTVP--QRL---LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR-GETDVS
    .   .|.     .  .|| |||||||.||||  ..|. . ... .   .|  ... .|| ||   .|.. || .|. ......  |.|.. 
atslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteie

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 93-332 1e-51 170.6 In-house 7-241 (250) alignment
Range on Protein: 93-332
Range on HMM: 7-241/250.0
KQNMHKNRYSDVVCRDTTRVKLTIDK-SRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPkCVGYWPSlGVTET
 || .||||.|..  | .|| |  .|  .  ||| | ....   |..|| ||||||.|| |||||...| ...|.|| .  |...  .  |||   ..|.
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.ekaek

YGCIRVTNMgeSSDEFEICNLAVTFVPDNvpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTV-----PQRLLAQVRHGPCVVHCSAGIGRTGCVVAL
|| ..|. .  |..||      . ..  .        . .|  |  ... .|||.|||..    .      |.   |.  .| .|.||||.||.|. .|.
yGdvtvsll..skeefadytkrklklska.......kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiai

EFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
.   ..| .  .||  ..|  |||.| . .... || ....... .
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_PTPRK_pd Subfamily PTPRK 93-340 2.8e-50 165.9 In-house 41-285 (314) alignment
Range on Protein: 93-340
Range on HMM: 41-285/314.0
KQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLgvTET
..| .|||. |..  | .||.| |||     ||| |... .    . || ||||||.|. ||||....|.. ||.|| . .|.|| ||. |||    ||.
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed..tev

YGCIRVTNMGESSDEfEICNlaVTFVPDNvpvdEQPANLKELRVNLIKWPNWPDRGVPDEKCHTV---PQ-RLLAQVRHGPCVVHCSAGIGRTGCVVALE
|| |.|. .  . .. |. .   .|   .     . .  .   |. ... .||| .|| ..   .    .     . ..|. ||||||| ||||. .|..
ygdikvelvetella.elvv..rifrvek....largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaid

FAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA-FARGETDVS
   . ..|   ||  ... .||...   ..|| || .|. |..     ||| . 
ivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaip

subfamily_PTPN13_pd Subfamily PTPN13 75-331 2.8e-49 162.8 In-house 16-267 (273) alignment
Range on Protein: 75-331
Range on HMM: 16-267/273.0
QYRKLDAQQDSSLTFEA-FKQNMHKNRYSDVVCRDTTRVKLTIDKSryedYIHANYVKTNYLRNTF--ICTQGPLQHTIIDFWRMIFQERAESILMLCKT
....|   .    . ..  |.|..|||| .|.  | |||||  . .    || |...| .   ...  | .|||| .|. |||.|... .|| | |. . 
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

MEEGRPKCVGYWPSLGVT--ETYGCIRVTNMGE-SSDEFEICNLAVTfvpdnvpvDEQPANLKElrVNLIKWPNWPDRGVPDEKCHTVPQ-RLLAQV--R
 |.|. ||  |||.        .. ..|....    |.| . .|||.        | . .. .|  |  ... .||| ||| .  . .   . ....   
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk........dsesgesre..vahlnfvkwPdhgvPssaaellqfvaevrrlqtd

HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
.|| ||||||||||.| ..... . . ..|  ..| .||. .||.||   .||. ||........ 
agPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 54-331 2.3e-48 159.5 In-house 4-281 (290) alignment
Range on Protein: 54-331
Range on HMM: 4-281/290.0
VETLNNFIIATEKLGIEGLAKQYRKLDA-QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSR---YEDYIHANYVKTNYLRNTFICTQGPLQHT
|. . .|..  .. | ||  .|. .||. ... . | .  ..| ..||....| .|  |. |    ..    ..||.| |.|    .. .| ||||...|
vdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsnt

IIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVTEtYGCIRVTNMGESSDE-FEICNLAVTfvpdnvpvdEQPANLKELRVNLIKWPNWPDRG-
..|||..| ||.   |.||.. .|||. ||  |||. .... || .... . |.. . . . .| |.         .. .. ..  |   .  ||.. | 
lvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevk.........nknsagakqsvtqyqitnwdstgk

VPDEK--CHTVPQRLLAQVRH--GPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
|....   ... ..   | ..  .. |||||...||..  .|.. . ||      .|  ... ..| |. . .||. || .|..... 
vtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt

0051429 (Phosphotyrosine protein) phosphatases II 121-352 2.4e-48 160.5 In-house 3-244 (272) alignment
Range on Protein: 121-352
Range on HMM: 3-244/272.0
YEDYIHANYVKTNYL---RNTFICTQGPLQHTIIDFWRMiFQERAESILMLCKTMEEGRPKCVGYWP-----------SLGVTETYGCIRVTNMGESSDE
...||.|..|....    ........|||..|. ||||.  ...  .|..|....| || ||  |||           .   | .||..|||.. |.  .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

FeicnlavtFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAqvrHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVD------
.        .. ..  .  .  . . ..| .. . .|||.|||.| .... . ||.   .||..||||||..|||.||||   .  ...   ||      
d........yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--FEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVSEKALAAADAFLK
   ||.. |||.||.. .||| |||..........|. ..|.. .|.|| ....
lyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaid

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 54-329 6e-48 158.3 In-house 3-267 (288) alignment
Range on Protein: 54-329
Range on HMM: 3-267/288.0
VETLNNFIIATEKLGIEGLAKQYRKLDaQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTiDKSRYedYIHANYVKTNYLRNTFICTQGPLQHTIIDF
 | .|..|    . ..||| |.||    .. |  . ..| .|  ..|| .. . |.|||||. | . .  ||.|| | ..  .. .||.| ||. ||  .
kevinawirlvlqiaveglkkeyrdsp.neasidiidsfianptrdryenlprcditrvkls.ddpdf..yiaanvvssakykrrlicaqaPlngtieel

WRMIFQERAESILMLCKTMEEGRPKCVGYWPSLgVTETYGCIRVTN-MGESSDEFEIcNLAVTFVPDNVPVDEQPanlkelRVNLIKWPNWPDRGVPDEk
|.|....  | |.|||. .| |..|   |.||  . |.    |. . . .. .. .   . |. .  . ...|.        |  . . .|.| |||.. 
WkmllesdveyivmlcellekGkeksaeyfPsk.lGekarigrlctvvkkkradidk.lvkvsllriskegeekv......ivkilhlleWdddgvPen.

cHTVPQRLLAQVR--HGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
 .  | |||  ..  . | |||.|||.|||| ..   .| . |     .  ......||..| ..|||| ||||.||..
.ylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcv

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 83-342 5.3e-47 155.7 In-house 49-301 (319) alignment
Range on Protein: 83-342
Range on HMM: 49-301/319.0
QDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCktmeegRPKCVG
. .  ||   .||  |||. ...  | ..|||  ..   . ||| | .|.    .. .| .||||. |. ||||||.. .. .|..|       . ||  
nladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWPSLGV-TETYGCIRVTNMGESSDefeicnlavtFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTV---PQ-RLLAQVRH--GPCVVHCS
|||  .| .|  . ..|. . |...          .|  .. . |.  .    ...  ..  ||| ||||     .    . | | .  .   . |||||
ywplkivikeerfkvkvdsveetae..........yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcs

AGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA-FARGETDVSEK
||.||||  ..|.   .....  .||  ... .||.|| . .|  .|| .|.  ..  .  | .||.  
aGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvamp

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 84-343 1.6e-46 154.1 In-house 14-266 (284) alignment
Range on Protein: 84-343
Range on HMM: 14-266/284.0
DSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCktmeegRPKCVGY
 .  ||   .||  |||. ...  | ..|||  ..   . ||| | ...    .. .| |||||. |. ||||||.. .. .|..|       . ||  |
gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy

WPSLGV-TETYGCIRVTNMGESSDefeicnlavtFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTV---PQ-RLLAQVRH--GPCVVHCSA
||  .| .|  . ..|. . ||..          .|  .. . |.  . .  ...  ..  ||| ||||   . .    . | | .  .   . ||||||
wplkivikeerfkvkvdsveesee..........yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

GIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA-FARGETDVSEKA
|.||||  ..|.   .....  .||  ... .||.|| . .|  .|| .|.  ..  .  | .||.   
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpd

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 68-356 1e-45 151.1 In-house 22-297 (315) alignment
Range on Protein: 68-356
Range on HMM: 22-297/315.0
GIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESIL
  .|. ..|  .   |   |      .| .|||| ...  | .||.|  ...    ||. ||...    .. .|..|||.  .. ||||..|.|    |.
tkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkiv

MLCKTMEEGRPKCVGYWPSLgvTETYGCIRVTNMGES-SDEFEICNLAVTFVpDNVpvdeqpanlKElrVNLIKWPNWPDRGVPDEKCHTV------PQR
|| ...|. . |.  |||      .|| | || . |   .|. .  |.|.|  ||.         .|  |  ...  ||| |||      .       | 
mltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfg.dni.........re..vvqlhytswpdmgvpkytiplmnlirtvkqh

LLAQVrhGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM-IAFARGETDVsekalaAADAFLKSYDE
  ..|  |. |||||||.||||  ..|.   ....    .|  ..|| .|..| . .|.  || .|. ..  .|  |.| .      | | .|..|| 
htnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsi......aqdlylqryds

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 60-341 1.3e-45 150.3 In-house 1-277 (281) alignment
Range on Protein: 60-341
Range on HMM: 1-277/281.0
FIIATEKLGIEGLAKQYRKLDAQQDSSLTfEAFK--QNMHKNRYSDVVCRDTTRVKLTI--DKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWR
| ....|. .. . ... .|  .  | |   .|.   | .||||... | | .||.| .   .    |||||||... .|.  .| |||| . |  ||||
famssqkmtlddfkqefsnlpgdppsdlc.tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwr

MIFQERAESILMLCKTMEEGRPKCVGYWPSlgvtETYGCIRVTNMGESSDEFEICNLAVTfVPDNVPVDEQpANLkelrVNLIKWPNWPDRGVPDEKCht
||.|| . .|.|||. .|  | ||  |.|     ... |... ..  | ..  . .  ||    |.  . . . |    .    | .|||  ||.     
miwqenttaivmlcqfletnrekcaeyfpr....nahcclqfdklsvsyedstvnkslvt.trlnlsyege.trl....ithwlwkewpdwqvpesse..

VPQRLLA--QVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKV-DFEEIITELRK-QRAQCIQTEIQYLYIHRVMIAFARGETDVSE
|  ..|   . |  | |.|||||.||.| ..|.| | . .   . . | ..|.. ||   ||  .||  ||. | .|.. |     ...|
vmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqite

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 54-332 2.2e-45 149.9 In-house 4-277 (287) alignment
Range on Protein: 54-332
Range on HMM: 4-277/287.0
VETLNNFIIATEKLGIEGLAKQYRKLDA--QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTidkSRYEDYIHANYVKTNYLRNTFICTQGPLQHTII
|| ...|.   .. | ||  .|.  |.   |.. ..| .  .|| .|||..... .|  || |     . .||| | ....   .. || ...|. .|. 
vekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntar

DFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVtETYGCIRVTNMGESSDEfeicnlavTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRG-VPD
.||..| ... . |.|||. .|. . .|  |||.     ..|  ... . |   .         ..  .. | ..  . ....|.  .  ||...| |..
nfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevna........gyierklevknknkagdkqqvkqyqitnWdstgkvte

EKC--HTVPQRLLAQVRH--GPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
 .     . ..  .| ..  .. |||||...||..  .| . . || ..   .|  ... . | |. . .||  || .|  .....
pqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley

0041856 (Phosphotyrosine protein) phosphatases II 95-334 2.2e-44 146.5 In-house 1-172 (182) alignment
Range on Protein: 95-334
Range on HMM: 1-172/182.0
NMHKNRYSDVVCRDTTRvkltidksrYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCktmeegrpkCVGYWPslgvtetygc
|..||||||... | .|         . |||.||..  ..  ..||.|||||..|. ||.||. ...  .|..|.         .. |||          
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

irvtnmgessdefeicnlavtfvpdnvpvdeqpaNLKELRVNLIKWPNWPDRGVPDekcH--TVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNK
                                  .| |  .  ... .||| ||||      ..     .. ..||..||||||.||||..||. . . .
..................................ellerlgiqylylpwpDhgvpd...ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl

ldrglKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
     .|..||.. ..|..| ....|. || ......  . .
.....gvsleeavklvrsrRpgmvitpnqyfflqlallelll

subfamily_egg_pd Subfamily egg 82-340 2.4e-43 143.0 In-house 27-277 (307) alignment
Range on Protein: 82-340
Range on HMM: 27-277/307.0
QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY-EDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEgrPKCV
 .. |||  | . |..| |   | |.|..|||| . . .| .|.||||.|| . | |.||..| ||. |  |||||.|||. . |.||  . |    .| 
vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

GYWPSLGV---TETYGCIRVTNMGESSD---EFEICNLAVtFVPDnvpvdeqpanLKELRVNLIKWpNWPDRGvpDekcHTVPQRLLAQVRH--GPCVVH
 |||           | .|..|..  |     | . .| .   .|           .|. ..  .. ..   .  |      | |.| ..|.   | ||.
yywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgd..........deerflehwqg.dvnnss..d...vysplrvlrklrnlskpvvvq

CSAGIGRTGCVVALEFAYNKLDRG--LKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVS
.  |. .....||.| |  .| ||   |    . .  ||..|   ... ..||...|... | |     .
dilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa

subfamily_PTPN23_pd Subfamily PTPN23 70-334 8.2e-43 141.3 In-house 15-281 (288) alignment
Range on Protein: 70-334
Range on HMM: 15-281/288.0
EGLAKQYRKLDAQQDS---SLTFEAFKQNMHKNRYSDVVCRDTTRVKLTidkSRYEDYIHANYVKTN-YLRNTFICTQGPLQHTIIDFWRMIFQERAESI
 .| |....|. .||    . .  . | . .|||. |..  | .||||    .  .||| | .||       .||.||.||| |. |||.|....... |
taldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssvi

LMLCKTMEEGRPKCVGYWPS-LGVTETYGCIRVTNMGESSDEfeicnlavTFVPDNVPVDEQPANLKeLRVNLIKWPNWPDRGVPD------EKCHTVPQ
 || .  | |.||.  |||.  | |...| ..||   . . |        |.|  .. .. ..|. .   | .... .||. |||.      .  . | .
VmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvrete........thvervlkletldadav.ksvshlqltsWpelGvPasPetllqfldeves

R--LLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLK-VDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
      .  . | |||||||.|||| .  .  | ..|..|   .|  ...  ||.||   .|.. |.     ...  ||
ayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 87-330 8.2e-43 141.5 In-house 40-276 (439) alignment
Range on Protein: 87-330
Range on HMM: 40-276/439.0
LTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRpkcvgYWPS
 .. | . .  |||| ||.  | ||| |  |    .  || |||.|  |  . .| |||| ..|  ||||.......  |.||.. .|  .     ||||
aslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps

LGVTeTYGCIRVTnmgeSSDEFEICNLAVTFVpdNVpVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVPQ-RLLA----QVRHGPCVVHCSAGIGRT
 . .  || | |        . |. | ..  .  .| ..|.  . ||  |  ...  |||. || .  | .   | .     .   || |||||||.|||
daev.cygdiavr....vdrnielpnyvirgf..kv.fnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrt

GCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
| ..||. | ..|    ||| . |.. ||||| | .|.  ||..|.  ..
Gtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl

subfamily_PTPN14_pd Subfamily PTPN14 82-333 8.3e-43 141.5 In-house 36-296 (300) alignment
Range on Protein: 82-333
Range on HMM: 36-296/300.0
QQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRYEDYIHANYVKTNY--LRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKC
..|. |.  . ..| .|||. ||.  . .||.|.  |   ..|| |  .|.     . ..| .||||..|. |||.|....  . |.|| .. |.|. |.
redallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeks

VGYWPSLG---VTETYGCIRVT-NMGESSDEFEICNLAVTFVPDNvpvdeqpanlKELRVNLIKWPNWPDRGVPDE---------KCHTVPQRLLAQV--
. |.|.|.    | ..|  .|| .. |.|| .    | . ..| .          .|  |  ... .|||.|||..         . . | ..   .|  
fkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk..........eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

--RHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA
  .. | .||||||.|||| ..  ..  . |. . ..| ..... ||.||   .||  || ....|.| . 
keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 69-350 9.5e-43 141.5 In-house 22-306 (325) alignment
Range on Protein: 69-350
Range on HMM: 22-306/325.0
IEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERaESILM
 .|.|...  | ...  . .  .  .|. |||. .||  | .|| | | ...   ||| |.|....  ...|. .| || .|| |.||.... |  |...
qdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvv

LCKTMEEGRPKCVGYWPSL-GVTETYGCIRVTNMgeSSDEFeicnlaVTFVPDNVPVdEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVP---------
.   ...|  .|  |||   | . |.| ..|  .  . .|.        .|   . |  |. . . . |.  ..  |.| ||.   .  ..         
vlneldlgkdrcavywpkemgksktfGglevklr..tieei......sdyvhrvldv.kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs

QRLLA-QVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA-RGETDVSEKALAAADAF
.|. |     .| .||||||.||||  ..|  | .|.    .||  . .  |||.| . ..|  ||  |.  .. .   |.|||   .. |  . 
ervtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklss

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 86-329 3.2e-42 139.5 In-house 35-273 (315) alignment
Range on Protein: 86-329
Range on HMM: 35-273/315.0
SLTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWP
  .    ..|..|||| ...  |..||||  ||.|  .||| | |.|.    ...|..||||. .. |||||..||.. .| |. |  |. . ||  |||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

S-LGVTETYGCIRVTNMGESSDEFEICNLAVTfvpdnvpvdEQPAnlKELRVNLIKWPNWPDRGVPDEKCHTVpqRLLAQVR------HGPCVVHCSAGI
   . .  .| |.|. .  ..|   .    ||          .    .  .|   .. .|||.||. .    .  .|. .|.      . . .||||||.
drkadsvefGsikvellsleadtdgvarklvt.........rkse..esrtvtqfqftewPdkGvdkqtssll..klikevkadngkkefsllvhcsaGv

GRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
|||| |....   ... |.  ||  .....||..| . .||| .| .|. ..
GrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydav

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 83-334 4.8e-42 138.7 In-house 24-278 (287) alignment
Range on Protein: 83-334
Range on HMM: 24-278/287.0
QDSSLTFEAFK--QNMHKNRYSDVVCRDTTRVKLTIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCV
. |..|| | .   ...||||.||.  | ||| |. .     ||| |||| .    ..||..|||.  |. ||||.....|. |.... . .||.| || 
esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

GYWPSLGVTETYGCIRVTNMGESSDEFEICNLAVTFVpdnvPVDEQPANLkelrVNLIKWPNWPDRGVPDE-----------KCHTVPQRLLAqvRHGPC
 |||   |    |   |. .  .  | | .  |.  .     .. . |..    |. ... .|||....             | |   .|  .    || 
kywPerevPmrvGGysvvlldydikePeygvralrli....dletrearv....vkqldllswPdkvlaPtavglirfvldvkqhielardas..evGPl

VVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
|||...||||.| ..|.    ..|    .||   ..  ||..||  .|. .|. ..   .... .
vvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 74-338 6.3e-42 138.4 In-house 13-272 (283) alignment
Range on Protein: 74-338
Range on HMM: 13-272/283.0
KQYRKLDAQqDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSryeDYIHANYVK---TNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCK
.....|    | . . .. ..| .|||. ..|  |  ||.|  .     ||| | ..     .   . .| .|.||..|..|||.|.|.|.. .|.|| |
evlkrlsvp.dldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

TMEEGRPKCVGYWPSLGvTETYGCIRVTNMGES-SDEFEICNLAVTFVpdnvpvDEQPANLKELRVNLIKWPNWPDRGVPDEK-CHTVPQRLLAQVRHGP
 .|. | ||  |||. | .| ||   ||   |  |. | | .| .             ..|      .| | .. .  . .        . |  . ..||
lqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvn......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgP

CVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFA-RGETD
 |||||.|||||.  .|.  . ...     ||  .... .|.||   .||  ||  .| ...  |  |.|.
ivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtq

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 78-340 8.5e-42 138.0 In-house 18-277 (285) alignment
Range on Protein: 78-340
Range on HMM: 18-277/285.0
KLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLtidKSRYEDYIHANYVKTN-YLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGR
|.        |. |.. |   |||.|| | . ||| |   | .  |||||....     ..|.| |||||  |. |||.||.||.   .||||  .| | 
kikgymppnctytayeanpdlnryadvrcieetrvvl...knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggv

PKCVGYWPS-LGVTETYGCIRVTnMGESSDEfeicNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVP-QRLLAQV--RHGPCVVH
 ||  |.|  ||    .|   .| . |  .|     .| | .     .. . |. . | .| .. | |||.  |..    .   . . .|  .  | .||
ekcalyypeklgevvkfgkyeit.lteckee....aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvh

CSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVS
||||.|||  .| ...|  ..    .... .|. |.|  | |..|. .|.|... |.. .  ||  | 
csagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvve

subfamily_PTPN9_pd Subfamily PTPN9 59-255 3.1e-41 136.3 In-house 5-195 (297) alignment
Range on Protein: 59-255
Range on HMM: 5-195/297.0
NFIIATEKLGIEGLAKQYRKLDAQQDSSlTFEA--FKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWR
...   .. |..|| |.| .. ... .  ||.|   . |..||||.||.| | |||.|. .|.  . |||.||.|     ...|| |||||..|. ||||
elvayvkekgkrGlskeyaeirnepveG.tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWr

MIFQERAESILMLCKTMEEGRPKCVGYWP-SLGVTETYGCIRVTNMGESS-DEFEICNLAVtfvpDNVPVDEQpanlkeLRVNLIKWPNWPDRGVPDEKC
|......  |.|  ...|.|| ||  ||| . . .. .| ..|.|.   . .....  | .    .||  .|.       .|   .   ||| |||..  
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvlei....knvktees......rkvthfqflsWPdyGvPssaa

HT
  
sl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 70-331 3.1e-41 136.0 In-house 15-291 (301) alignment
Range on Protein: 70-331
Range on HMM: 15-291/301.0
EGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKS---RYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESIL
.....||..|. ..| | | .  ..| . ||. ...  |  |. |.  ..     ..|| |.|..    .. || .|||...|..||||.|.||.  ||.
nkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLCKTMEEGRPKCVGYWPS-LGVTETYGCIRVTNMGES-SDEFEICNLAVTFVpDNVP---VDEQPA---NLKELRVNLIKWPNWPDRGVP---DEKCHT
|.... |. . ||  |||.    .|..| . || . |    .| | .|.|.   |      .  . .   . .   |  ..  .||. ||        . 
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiq.dgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqv

VPQRLLAQ--VRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIA
. . . .|  .  || |||||....|.|  .... .     .   ||  ...  .|...   ..|  ||  |. |.  
iddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 93-329 1.1e-40 134.3 In-house 41-272 (515) alignment
Range on Protein: 93-329
Range on HMM: 41-272/515.0
KQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPS-LGVTE
. | .|||| ...  |..||||  |. .  .||. | |...    ...|..|||.. .. ||||...||.   | |. |  |. . ||  |||   | . 
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

TYGCIRVTNMGESSDEFEICNlAVTFVPDNvpvdeqpanlKELRVNLIKWPNWPDRGVPDEKCHTvpQRLLAQVR--H----GPCVVHCSAGIGRTGCVV
 .| |.|  .  ...   |    .| . ..          .   |   .. .|||.||| .       .|. .|.  |     | ..|||||.|||| |.
kfGsikvelvsleactggikr.kltvlkgd..........dsrtvtqfhfteWPdkGvpkhtssl..lklikevkadhgqythpliihcsaGvGrtGvvi

ALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
...    .   .  ||  ...| .|..| . .||. || .|. ..
sidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygav

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 72-334 2.2e-40 133.3 In-house 21-277 (312) alignment
Range on Protein: 72-334
Range on HMM: 21-277/312.0
LAKQYRKLDA-QQDSSLTfeAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRyedYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCK
|.|.|. .    .||  |  || .    ||| .. | |  |  |. |.     |||||.||     . |.||||||. |.  ||.. .   . ||..|| 
ltkeykavgnivsdsect..aflkfkdlnrypniqcwdrgrftlagdenf...yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

TMEEGRPKCVGYWPSLGVTETYGCIRVtnMGESSDEFEICNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDeKCHTVpQRLLAQVRH--GP
 .|.|  ||. |   .         ||    |.  | ||   .   .   |      |  .| ..|  .|  ||| |.||  | |  .|||. |..   |
fvedgsekcakyisdivgfvdledhrv..yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpd.scdta.lrllsavkkdkkp

CVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
 . |||||.|||| .. .|     |    | .  ..   |||.||. ...  ||.|  |... |  
viahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 91-330 4.5e-40 132.6 In-house 46-281 (297) alignment
Range on Protein: 91-330
Range on HMM: 46-281/297.0
AFKQ-NMHKNRYSDVVCRDTTRVKLTIDKSR-YEDYIHANYVKTNylRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRpKCVGYWPSLGV
| |. |..|.||....  |. |||| |  .    ||. | .||.|  .. .|.|| | . |. |||.|...|..  |.|| .  |. . ||  ||.  ||
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgn..khrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

TEtYGCIRVTNMGESSdefeicnlAVTFVPDNVPVDEQPANLKELrVNLIKWPNWPDRGVPDEKCHTVPQRLLAQVR-------HGPCVVHCSAGIGRTG
|. .| . |. .  |.           |.  .. | .. |  . . |.  .. .|||. |. ..  .  . |. .||       .|| .|||.||.||||
tt.fGdvsvvllsvse........reGfikrelevtkgkakarrv.vkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg

CVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
 .....    .  |  .||  .... ||..| . .||. || ... ...
vlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavl

subfamily_PTPN1_pd Subfamily PTPN1 84-327 1e-39 131.0 In-house 21-265 (290) alignment
Range on Protein: 84-327
Range on HMM: 21-265/290.0
DSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSryeDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYW
| . .   ...|  .||| ||   | .|.||  ..    ||| |. |. . ..  .| ||||| .|.  ||.|...... ...|| | .|... ||. ||
dfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PSLGVTETYG----CIRVTNMG-ESSDEFEICNLAVTFvpdnvpvdeqpANL-KELRVNLIKWPNWPDRGVPDEKCHTVpqRLLAQVR--------HGPC
|.   ...       ..|. .  |..... .  | ..             .  .   .   ..  ||| |||.     .  ..| .||        .|| 
Pqgeeekellledtklkvkliseerksyytvrllelen...........lktqetreilhfhyttwpdfgvpespaafl..kflfkvresGslssdvGpa

VVHCSAGIGRTGCVVALEFAYNKLDRGLK---VDFEEIITELRKQRAQCIQTEIQYLYIHR
|.||||||||.| .. ..    ....  .   || .. . ||||.|   |||  |  . . 
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl

0049772 (Phosphotyrosine protein) phosphatases II 80-332 1.1e-38 129.1 In-house 31-279 (314) alignment
Range on Protein: 80-332
Range on HMM: 31-279/314.0
DAQQDSSLTFEAFKQNMHKNRYSDVVCRDtTRVKLTIDKSRYEDYIHANYVKTNylrNTFICTQGPLQHTIIDF----------WRMIF--QERAESILM
 . .. ....  .  |..|||| |... | .||.|     .  |||.|.||..    ..||.|||||..|..||          |||..  . .   | |
svlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------LCKTMEEGrpkcvgywpslgvtetygcirvtN----------MgessdefeicnlavtfvpdnvpvDEQ--PANLKELR
                     |.. .. |                       |                                  .|.  |  ...| 
srdevladelsrLdaAlgKtpllildgng.......................neptaadlellk.......................eelydpelferlg

VNLIKWpNWPDRGVPDEKCHTVPQRLLAQ-VRHGPCVVHCSAGIGRTG--CVVALEFAYNkldrglKVDFEEIITELRKQRA-----QCIQTEIQYLYIH
.... . ..|| ..|...      ... .  ..|| .|||.||.||||  .|.|.   ..      .|..||.. ..|..|       .|.. .||..|.
ikylri.pvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll......gvsleealedvrlkRpinpnpgfieqleqyefil

RVMIAF
...  .
ealley

0046846 (Phosphotyrosine protein) phosphatases II 120-331 4e-38 126.3 In-house 10-171 (176) alignment
Range on Protein: 120-331
Range on HMM: 10-171/176.0
RYEDYIHANYVKTNYlrntFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlgvTETYGCirvtnmgessdefeicnlavtfvpd
 . |||.||.. ...    .|.||||| .|. ||..|..... . ...|.. .| || ||  |||     |..|.                         
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.........................

nvpvdeqpanlkelrvnLIKWPNWPDRGVPDEK--CHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNkldrGLKVDFEEIITELRKQRA-QCI
                  ... .||| |||| .  .. . .   |. ..|| .|||||||||||..||.   .     .  .. ||.. ..|.||  ...
.................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgav

QTEIQYLYIHRVMIA
||. || ......  
qtpeQyrflyefell

0043147 (Phosphotyrosine protein) phosphatases II 121-326 1.7e-37 124.1 In-house 4-154 (172) alignment
Range on Protein: 121-326
Range on HMM: 4-154/172.0
YEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTmeegrpkcvgywpslgvtetygcirvtnmgessdefeicnlavtfvpdn
..|||.|.|....|  . ||.|||||..|. |||||. ..    |..|..                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

vpvdEQPANLKELRVNLIKWPNWPDRGVPdEKCHTVP-----QRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYnkldrgLKVDFEEIITELRKQRAQC
    . .. | |  .  . . .||| |||    .        ..|||. ..||..||||||.||||..||.   .      |....||.. ..|..| ..
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpga

IQTEIQYLYIH
.|.. || ...
vqnpsqyrfly

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 94-329 3.1e-37 123.1 In-house 2-235 (237) alignment
Range on Protein: 94-329
Range on HMM: 2-235/237.0
QNMHKNRYSDVVCRDTTRVKLTIDKSRyEDYIHANYVKT-NYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVTETY
.|  ||||...|. | .|| |    |   ||| |.|.|  .   ...|..||||. .  |||.|..||.   |.||   .|  . ||  ||||    ..|
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GCIRVTNMgeSSDEFEicNLAVTFVpdnvPVDEQpANLKELRV-NLIKWPNWPDRGVPDEKCHTV--PQRLLAQVRH----GPCVVHCSAGIGRTGCVVA
| . |.      .||   . .|  .     . ..  .|||.|.    ..  |||||||.. .  .   .... . .|    || ..|||||.|||| .. 
gvltvslk..kkeefs..dytvrsl....llskr.ltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflv

LEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
..    .      ||  . .  . ..|   |||. ||..||...
idamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti

0036282 (Phosphotyrosine protein) phosphatases II 122-327 1e-36 121.6 In-house 2-164 (174) alignment
Range on Protein: 122-327
Range on HMM: 2-164/174.0
EDYIHANYVKTNYLRNTFICTQGPLQhtiidFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlgvtetygcirvtnmgessdefeicnlavtfvpdnv
.|||.|.... .|  . .|..||||.     ||.|..... ....||.. .| |. ||  |||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

pvdeqPANLKELRVNLIKWPNWPDRGVPDE----KCHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDrGLKVDFEEIITELRKQRAQCIQ
       .  |  .  ... .|||.||||     ..    .. |.. ..||..||||||.||||..||.   .  |     ||  ... |||.|| ...|
.....lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvq

TEIQYLYIHR
|. || ... 
tpsQyrflyy

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 96-325 1.7e-35 117.3 In-house 51-273 (301) alignment
Range on Protein: 96-325
Range on HMM: 51-273/301.0
MHKNRYSDVVCRDTTRVKLTIDKSRYEdyIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLgVTETYGCI
 .|.||  | |. .| |..  |  |    ||||...|.   . ||.|||||. |  ||| |. |   | | ||....|.   ||  | |.  ..|.    
kdkhryptvPckPstavevivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvk.isekldig

RVtNMGESSDEfEICNLAVtfVPDNVPVDEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDR
|  ..   . |  | |  .  .  .. | .   ...   |   .. .|.|||||  . ..     |..  . | ||||||||||. . .. |.  .... 
rf.kikiknke.lilnkki..skrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarevea

GLKVDFEEIITELRKQRAQCIQTEIQYLYI
  .... | . .||..| . .||. |  ..
dptieltealkhlrehrwngvqtnsqlywm

subfamily_CG7180_pd Subfamily CG7180 92-330 3e-35 116.3 In-house 39-287 (296) alignment
Range on Protein: 92-330
Range on HMM: 39-287/296.0
FKQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRpKCVGYWPSLGvTE
 |.|. |||. .||  | .|| |. .|    .||| | || .    . .| |..| ..|. .|||....| .... .|.||..  . ..  |||  .  |
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.ke

TYGCIRVTNMGE-SSDEFEICNLAVTFVPDNVPVDEQPANLKELRVNLIKWPNWPD-RGVPDE-----KCHTVPQRLLAQV----RHGPCVVHCSAGIGR
 || | |  . | .  ...| .. .|     .   |.. . ..  | |...  |.    ||       .     . .  .|     .|| ||..| | .|
qygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasR

TGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
.|  .|.. . .....  .||. | .  ||..| | ...  .| ||  |. 
sGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll

0049260 (Phosphotyrosine protein) phosphatases II 131-326 9.9e-35 114.8 In-house 3-143 (152) alignment
Range on Protein: 131-326
Range on HMM: 3-143/152.0
KTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWpslgvtetygcirvtnmgessdefeicnlavtfvpdnvpvdeqpanl
.  .  . ||.||||. .|. |||||. .  .  |.||.. .| |..||  |.                                               
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................

kelrvnLIKWPNWPDRGVPDEKCHTVPQRLL----AQVRHGPCVVHCSAGIGRTGCVVALEFAYnkldrgLKVDFEEIITELRKQRAQCIQTEIQYLYIH
       ... .||| ||||   .     |.    |. ..||..||||||.||||..||.   .      |.|..||..  .|..| . .... |. ...
......qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly





subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 87-328 3.9e-34 112.7 In-house 37-231 (392) alignment
Range on Protein: 87-328
Range on HMM: 37-231/392.0
LTFEAFKQNMHKNRYSDVVCRDTTRVKL-TIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGrpkcvgywps
 |    . |..|||| ...  |..||||  || .  .||. | |...    ...|..|||   .. |||||.|||.. .| |. |  |            
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

lgvtetygcirvtnmgessdefeicnlavtfvpdnvpvdeqpaN-LKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQVRHG----PCVVHCSAGIGRT
                                           .  .   |   .. .|||..||   .  .      .. .|    | ..|||||.|||
...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrt

GCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRV
| |....    .  .   ||  ...|..|..|   .||. || .|.  
gvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiyga

subfamily_PTPRN_pd Subfamily PTPRN 73-326 1.2e-32 107.8 In-house 32-285 (297) alignment
Range on Protein: 73-326
Range on HMM: 32-285/297.0
AKQYRKLDAQQDSSLTF--EAFKQNMHKNRYSDVVCRDTTRVKLTIDKSR-YEDYIHANYVKTNYLRN-TFICTQGPLQHTIIDFWRMIFQERAESILML
.|..  | | .    |      ..|..|||...|.  | .||||. . |.  .||| |  .  .  |. ..| ||||| .|. |||.|.... .  |..|
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

CKTMEEGRPKCVGYWPSLGvTETYGCIRVTNMGES--SDEFeicnLAVTFVPDNVPVDEQPAnlkelrVNLIKWPNWPDRGVPDEKCHTVPQRL-LA---
..  |||  .|  |||  | .|.|.   |  . |   .|..    |  .|   |.  .|  .      |   ..  ||..||| .    .  |  .    
trleeegvkqckrywpdeG.sevyhiyevhlvsehiwcddy....lvrsfylknlqtsetrt......vtqfhflswpeegvPasaksllefrrkvnksy

QVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLK-VDFEEIITELRKQRAQCIQTEIQYLYIH
. |  | |||||.| ||||. .....  |.| .|.| .|    .  || ||.. ..|. |. .. 
rGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefal

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 94-329 2.6e-32 106.9 In-house 7-237 (239) alignment
Range on Protein: 94-329
Range on HMM: 7-237/239.0
QNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTN-YLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlgVTET
 |  ||||...|  | .|| |  . .  . ||| |.|..      ...|.||| .. .  |||||..|||   |.||   .|  . ||  |||    |  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..stsk

YGCIRVTNMgesSDEFEICNLAVTFVPDNVpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQR--LLAQVR--HGPCVVHCSAGIGRTGCVVALE
|  .|||       |     .  |||  .|       . .|  |   ..  |||.|||.     .  |  .  .      | |.|||||.||||... ..
ycnlrvtlr...ktevfadyiirtfvmsqv......gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

FAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
    .  .   ||  . .  .|..| . .||  ||..||  .
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 94-329 2.8e-32 106.8 In-house 6-236 (239) alignment
Range on Protein: 94-329
Range on HMM: 6-236/239.0
QNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTN-YLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSlgVTET
 |  ||||...|  | .|| |  . .  . ||| |.|..      ...|.||| .. .  |||||..|||   |.||   .|  . ||  |||    |  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..stsk

YGCIRVTNMgesSDEFEICNLAVTFVPDNVpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQR--LLAQVR--HGPCVVHCSAGIGRTGCVVALE
|  .|||       |     .  |||  .|       . .|  |   ..  |||.|||.     .  |  .  .      | |.|||||.||||... ..
ycnlrvtlr...ktevfadyiirtfvmsqv......gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

FAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
    .  .   ||  . .  .|..| . .||  ||..||  .
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav

0051082 (Phosphotyrosine protein) phosphatases II 121-328 5.6e-31 102.5 In-house 2-148 (151) alignment
Range on Protein: 121-328
Range on HMM: 2-148/151.0
YEDYIHANYVKTNylrntFICTQGPLQhtiiDFWRMIFQERAESILMLCKTMEEGrpKCVGYWPSLGvtetygcirvtnmgessdefeicnlavtfvpdn
..|||...||  .     .....|||.    ||.... ..   .|..|....| |  .|  |.|.||                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

vpvdeqpanlkeLRVNLIKWPNWPDRGVPD--EKCHTVPQRLLAqVRHGPCVVHCSAGIGRTGCVVALEFAYNKldrglkVDFEEIITELRKQRAQCIQT
            ..|  | ...||| |.|.  . .  . . ||.  ..||..||||||.||||..|||   . .      |..||.. |.|..|  ..|.
............ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp

EIQYLYIHRV
. |.|.....
nqqflfqlfa

subfamily_ptpA1_pd Subfamily ptpA1 69-298 7e-31 102.4 In-house 20-261 (418) alignment
Range on Protein: 69-298
Range on HMM: 20-261/418.0
IEGLAKQYRKLDAQQDSSLTFEAF-KQNMHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTNYLRnTFICTQGPLQHTIIDFWRMIFQERAESIL
|  . ...| |.     | | |   |.|  ||||....  . |||.|  |.     ||| |||.   | .  ||||||||  || |||||....|.  |.
ihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriiv

MLCKTMEEGRPKCVGYWPSLGVTETYGCIRVTNmgESSDEFEICNLAVTFVPDNVPVDEQ--PANLKELR-VNLIKWPNWPDRGVPDEK------CHTVP
|| .  |. | ||  |||     | .      |  |    . .  . |   |.   .  .   .   | | .   ..  |||. .||         |.. 
mlsresencrikcdrywpeqiggeqfsiygngn..evfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsit

QR----LLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLK
.|    . .  |  | .||||||.|||| ...     .|||. .|
nrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfk

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 51-336 8e-31 101.6 In-house 8-288 (302) alignment
Range on Protein: 51-336
Range on HMM: 8-288/302.0
RKYVETLNNFIIaTEKLGIEGLAKQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKsryEDYIHANYVKTNYLRNTFICTQGPLQHTI
.|.||  ..  . ...|    . |.. |.|... .    .|||.|..||.  || . |...|||.  .   ..|..|  |.   |... | .| | . . 
ekWveeeeakkl.vksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaep...dsyvnaskvevPeltrsiilaQlpkvdse

---IDFWRMIFQERAESILMLCKTMEEGRpKCVGYWP-SLGVTETYGCIRVTNMGESSDEFEICNLAVTFVPDNVpvdeqpANLKELRVNLIKwpNWPDR
    .||||.|||.  |. .| .. |  .     ..|   |  ..|| ..| |   .. | |  ....  .|...      .|     |....  ||.. 
dsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegc......snsvlanvyvlt..nWkqk

GVPDEKCHTVPQRLLA----QVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGE
 ||..  ... .        .    ..|.    |.|| | ...|  | .||..| ..  .||.. .|.||.. ... .||  ...... . . .
kvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 80-251 4.3e-29 96.3 In-house 18-182 (297) alignment
Range on Protein: 80-251
Range on HMM: 18-182/297.0
DAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDkSRYEDYIHANYVKTN--YLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRP
| ..  |..    .  ..|||| |..  |.|||||       .||| |.||          .|..||||. |. |||......    | |..|  |.|| 
deargesfssakrnsslrknryrdilatddtrvkllrv.iterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

KCVGYWPSL-GVTETYGCIRVTNMGESSDEFEICNLavTFVP--DNvpvdeqpanLKELRVNLIKWPNWPDRGVPDE
||. ||||  .   . | . |  . . ||||.   |  | .               ..  |. ... .||| ||| .
kcapywpsvvqerlkagdvvveflsstsdefdrvil..telqliyr.........sesrvvrhvqflswpdhGvpsd

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 94-341 2.6e-28 94.0 In-house 18-257 (290) alignment
Range on Protein: 94-341
Range on HMM: 18-257/290.0
QNMHKNRYSDVVCrDTTRVKLTIDKSRYE-DYIHANYVKT-NYLRntFICTQGPLQHT-------IIDFWRMIFQERAESILMLCKTMEEGRP----KCV
..  ..|..  .    ||| |   ..|.  ||||||.|.  | ||  .| || |....       | .|| |. ||..... |||. .|. .      | 
khemdqRlevpLv.eatrvvLkgygkrfnddyiHAnrvtcpnglr..liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCa

GYWPS-LGVTETYG--CIRVTNMgESSDEFEICNLAVTFvpdnvpvdeqpANLKELRVNLIKWPNWPDRGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGI
 | |   |   ...   .. ... |  |..|. .| |.|            . .|. |.  .  .| .. |....   .      . .. | .|||  ||
kYvpesvgeelkfkgltvkCksk.ekeddvetRelvvkf...........ddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGi

GRTGCVVALEFAYNKLD-RGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIafargetdvsE
 |  .. |.. .| |.     .| .|... .||||||..|...... ..  ...           
SrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv..........l

PTPc_DSPc_SM00012 235-330 1.4e-27 91.3 In-house 2-104 (105) alignment
Range on Protein: 235-330
Range on HMM: 2-104/105.0
VNLIKWPNWPDRGVPDEKchTVPQRLLAQVRH--------GPCVVHCSAGIGRTGCVVALEFAYNKLDRG-LKVDFEEIITELRKQRAQCIQTEIQYLYI
|. .....||| |||.|   .   .||..|..        .|.|||||||.||||..|||. ....|...  .||...|. ||||||....||| |||..
vkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

HRVMI
.|...
yrall

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 90-336 2.8e-27 90.4 In-house 28-262 (267) alignment
Range on Protein: 90-336
Range on HMM: 28-262/267.0
EAFKQNMHKNRYSDVVCRDTTRVKLTidkSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCvgYWPSLGVT
   ..|  .||. |..  | ||| |     . |.|| | ||.. . .|.|| ||.||. || ||. .| ...   | .| |. ..  ..   . | .| .
siaeknqernrlddnlpyddtrvilr...tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlf..wPPkmgqa

ETYGCIRVTNMGE-SSDEFEICNLAVTFVPDNVpVDEQPANLKELRVNLIKWPNWpdrgvpdEKCHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEF
. |  . |    |   ....|  | . |  ..   .      |.  .|  . |         .    .  .   .    | ||.||.|.||.|  . .. 
kkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnintnnkpyl.......kplfgilaknqlengnrPlvvacsdGvGrsGtflvids

AYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARGE
  ... .   .|  . . ..|.||   ..|  .|.|||...  .|.| 
qleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegr

0044763 (Phosphotyrosine protein) phosphatases II 119-327 2.5e-26 87.8 In-house 15-165 (178) alignment
Range on Protein: 119-327
Range on HMM: 15-165/178.0
SRYEDYIHANYVKTNylrnTFICTQGPlqhtiIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLGVtetygcirvtnmgessdefeicnlavtfvp
  . |||.|...  .     ......|      |..... ..   .|..|....| |..||  |||.                                 
lersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............................

dnvpvdeqpanlkelrvNLIKWPNWPDRGVPDEKCHTVPQRLLAQ----VRHGPCVVHCSAGIGRTGCVVALEFAYNKldrglKVDFEEIITELRKQRAq
                    .. ..|| ||||   |.     . .     ..||..||||||.||.|..||.   .       ....||.| ..|..|  
.................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.

CIQTEIQYLYIHR
..... |. ....
ivpnpgqlrqLye

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 74-327 4.8e-21 69.7 In-house 26-273 (303) alignment
Range on Protein: 74-327
Range on HMM: 26-273/303.0
KQYRKLDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTiDKSryedYIHANYVKTNYLRNTfICTQGPLQHTIIDFWRMIFQERAESILMLCKTME
... |. .    |.. . | .||.|||. ||.| | ..|||. | |    ||||.|.. .  ... | || ||.||  |||.|| ...   .|.|    |
nefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls.dss....yihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdse

EGRpkcVGYwpSLGVTETYGCIRVTNMGESSDEFEICNLAVTFVPDNVPVDEqpANLKELrVNLIKWPNWPDRGVPDE-KCHTVPQ-----RLLAQV-RH
  .   .|        .    ..  .      ||   .|.  .|   . | .   . | . . . .. .||   .| .   . | |      .| .    
ydk...lgg..dsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsn..gdyksf.lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysds

GPCVVHCSAGIGRTGCVVALEFAYNKLDRG-LKVDFEEIITELRKQRAQCIQTEIQYLYIHR
 | |    .| ||.|    .| |.  |      .|.   .  .|. | ...|   |. ... 
tptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvyt

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 94-222 6.8e-21 69.4 In-house 46-187 (350) alignment
Range on Protein: 94-222
Range on HMM: 46-187/350.0
QNMHKNRYSDVVCRDTTRVKLT--------IDKS-RYEDYIHANYVKTN----YLRNTF--ICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPK
. . ||||....  . .||||         ...| . .||| |||.| .         |  | ||.||. |. ||...|..   . ||.| . .| .. |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CVGYWPSLGVTETygCIRVTNMGESSDEFEICNLAVTFVPDNVP
|  ||. ... .    ...... |.  . . . | .. |  . .
cyrYWqegsyddi..tvklaskwenimgindsslysadvkkeas

0048076 (Phosphotyrosine protein) phosphatases II 202-328 5.9e-20 66.9 In-house 18-138 (145) alignment
Range on Protein: 202-328
Range on HMM: 18-138/145.0
ESSDEFEICNLAVTFVPDNvpvdEQPANLKELRVNLIKWPNWPDRGVPDE--KCHTVPQRLLAQVR-HGPCVVHCSAGIGRTGCVVALEFAYNkldrgLK
  .|  ....| .| | .         .| |  .  . . .|||.||||      .. . . . .. .||..||||||.||||..||.   .      |.
taldlellkdlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lg

VDFEEIITELRKQRAQCIQTEIQYLYIHRV
|..||.. ..|.|| ...... |. .....
vsleealelvrsqrpgavpnpgqlrflyef

0048179 (Phosphotyrosine protein) phosphatases II 198-327 1.3e-19 65.8 In-house 14-139 (144) alignment
Range on Protein: 198-327
Range on HMM: 14-139/144.0
TNMGESSDEFEICNLAVTFVPDNVPvdEQPANLKELRVNLIKWPNWPDRGVPDEKCHTVPQ-----RLLAqvRHGPCVVHCSAGIGRTGCVVALEFAYnk
 ..  ..|  ....| .| | . ..  | . .  |  .  . . .|||.||||   .         ..|.  ..||..||||||.||||..||.   .  
gslptaldlellkklgittvinlte..eyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk..

ldrGLKVDFEEIITELRKQRAQCIQTEIQYLYIHR
    |....||.. ..|..| ...... |. ....
...klglsleealalvrsrrpgavpnpgqlrfLle

subfamily_PTPN9_pd Subfamily PTPN9 261-335 5.1e-19 63.4 In-house 218-292 (297) alignment
Range on Protein: 261-335
Range on HMM: 218-292/297.0
LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFARG
  ...  | ||||||||||||  ..|... ..|..  .||  | .  ||.|||  |||. || . .  .. .|  
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale

subfamily_CG42327_pd Subfamily CG42327 96-254 4.2e-18 60.1 In-house 29-182 (319) alignment
Range on Protein: 96-254
Range on HMM: 29-182/319.0
MHKNRYSDVVCRDTTRVKLT-IDKSRYEDYIHANYVKTN-YLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPS---LGVTE
  |.|. .||    ||| |  | .   . |..|.||.     .| .|..| .|. .  ||||.... ..  |. |..  | |  .|  |.|.   |  |.
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

TYGCIRVTNM-GESSDEFEICNLAVTfvpdNVpvDEQpanlkELRVNLIKWPNWPDRGVPDEKCH
.|| |.||   .|. |.. |  | .     .|  |..     | |     | .|.. .|| |.  
lyGdilvtlkgrevkdryaistlllk....rv..dke.....esrelthywykwleaevPaeeaa

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 126-333 1.6e-17 58.4 In-house 39-221 (255) alignment
Range on Protein: 126-333
Range on HMM: 39-221/255.0
HanyvktnylrntfictqgplqhTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPslgvTETYGCIRVTNMGESSDEfE-----ICNLAVTFvpdN
                       |.  |...| | ..| . |||   |||. ||  |.|    .|  .  .....  .. .       .  | .|    .
l......................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfp....lekdeklkladvnvtttk.ssadvvlrtleits...t

vpVDEqpaNLKELRVNLIKWPNWPDRGVPDEKcHTVpQRLLAQVRH-GPCVVHCSAGIGRTGCVVALEFAYNKLDRGL------KVDFEEIITELRKQRA
  . |     |   |.  ..  |...  |..  . . . .|  ||.  . |||||.||||.   |  |..| |. | |      ..|. ....|||..|.
..lge...kkkthtvkhysykGWieknaPela.rei.lnilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrk

QCIQTEIQYLYIHRVMIAFA
. |.| .|  .   ... . 
raihtPlqlafsilmvldlv

subfamily_CG42327_pd Subfamily CG42327 261-334 2.5e-17 57.5 In-house 242-316 (319) alignment
Range on Protein: 261-334
Range on HMM: 242-316/319.0
LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRG-LKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMIAFAR
  . ..|| ||||| |.|||| |.| ..| ..|.     ||  ...  .|..||. ..|  || .|..|.  .|.
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 144-326 2.9e-17 57.1 In-house 98-281 (302) alignment
Range on Protein: 144-326
Range on HMM: 98-281/302.0
GPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPS-LGVTETYGCIRVT--NMGESSDEFEICNlavTFVPDNVPVDEQP-ANLKELRVNLIK
 | . |.  .| .| | .   .  ||. .|..  ||  |.   .| . ..|   |.  .. .  .||   .   .|.  .| . ..   . ..  |....
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkk...sfklytveiknekkkkkvkktvdila

WPNWPDRGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIH
.  ||| | |.|  ...      .      .||||||.|||| .||. .  .   .    |. .|.. .|. |   .|.| | .|. 
fsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll

subfamily_hpo-7_pd Subfamily hpo-7 126-333 1.8e-15 51.6 In-house 42-232 (263) alignment
Range on Protein: 126-333
Range on HMM: 42-232/263.0
HanyvktnylrntfictqgpLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPslgvTETYGCIRVTNMGESSDEFEICNLAVTFVPDNVpVDE
                    |  ||  |...| | ..| . |||   |||. ||  |.|    .|  .  ...|.  .. .     |  | .  .. ..|
l...................lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfP....lekdekqklanvnvcttkvqsdvllktlellst.lge

qPANLKELRVNliKWPNWPDRGVPDEKCHTVpqRLLAQVRH-GPCVVHCSAGIGRTGCVVALEFAYNKLDRGL------KVDFEEIITELRKQRAQCIQT
   ...... .  ..  |...  | .    .  ..|  .|.  . |||||.||||.   .  |..| |. | |      ..|. ....|||..|.. |.|
.Kkkthtvkhy..sykgWiekndpelareil..nilkvarnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht

EIQYLYIH-----RVMIAFA
 .|  .        |. .||
PmqLafsilmvLdfvlnnfa

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 264-330 2.1e-13 44.8 In-house 226-292 (297) alignment
Range on Protein: 264-330
Range on HMM: 226-292/297.0
VRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
 |  . .||||||.||.| ||  .   .|| ..   |   |.. ||.|||. .||  |. ... ...
prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 236-341 3.5e-13 43.7 In-house 92-203 (440) alignment
Range on Protein: 236-341
Range on HMM: 92-203/440.0
NLIKWPNWPDRGVPDEKCHTVP-----QRLLAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
.  ..  |||.|||      .      .    ..  || .|||||| |||| ..|..    .  |  ..|   .|  .|..| | .||  || ..| ...
kqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavl

-AFARGETDVSE
 ..  |.| . |
egllcgdtlile

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 80-167 9.8e-13 42.3 In-house 22-115 (347) alignment
Range on Protein: 80-167
Range on HMM: 22-115/347.0
DAQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRY------EDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILM
 .   | .|.  ..... |||  ||   |.||| |. .||.       | || | ..| .  .. .| || || .|. |||.|..  .   .. 
anyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 102-221 1.8e-12 41.3 In-house 55-189 (349) alignment
Range on Protein: 102-221
Range on HMM: 55-189/349.0
SDVVCRDTTRVKL---------------TIDKSRYEDYIHANYVKTNYLR--NTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWP
.|..  . .||||               . | .. .||| |||.|   .   . .|.|| ||  |. ||...|  .. . .| | .  |..  ||  || 
kdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq

SLGVTETygCIRVTNMGESSDEFEICNLAVTFVPDNV
 |  ..    ... |  . . . . . | |  | |. 
elsysni..tvklqnsslyianvqGnslrvstvkdtd

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 138-327 5.9e-12 40.2 In-house 6-198 (199) alignment
Range on Protein: 138-327
Range on HMM: 6-198/199.0
TFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLG-VTETYGCIRVTNMGE-SSDEFEICNLAVTfvpDNVpvdEQPANLKELrv
 .|.|| ||..|. |||.|...  .  |.|.     .       |||.    |  ||.. ||     .  .. |. | .|   .|.     |   .|.  
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt...nnt...tappstrei..

NLIKWPNWPDRGVPDEK---CHTVPQRLL----AQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLD--RGLKVDFEEIITELRKQRAQCIQTEIQYLYIH
   ..  | ..  |.        |  | .     | .  | .|||| | | ||  |||.      .  .   ||. |.   ||. |   | .  .| .|.
shyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

R
.
q

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 138-327 5.9e-12 40.2 In-house 5-197 (198) alignment
Range on Protein: 138-327
Range on HMM: 5-197/198.0
TFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGRPKCVGYWPSLG-VTETYGCIRVTNMGE-SSDEFEICNLAVTfvpDNVpvdEQPANLKELrv
 .|.|| ||..|. |||.|...  .  |.|.     .       |||.    |  ||.. ||     .  .. |. | .|   .|.     |   .|.  
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt...nnt...tappstrei..

NLIKWPNWPDRGVPDEK---CHTVPQRLL----AQVRHGPCVVHCSAGIGRTGCVVALEFAYNKLD--RGLKVDFEEIITELRKQRAQCIQTEIQYLYIH
   ..  | ..  |.        |  | .     | .  | .|||| | | ||  |||.      .  .   ||. |.   ||. |   | .  .| .|.
shyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

R
.
q

subfamily_eak_pd Subfamily eak 78-198 7e-12 39.4 In-house 34-155 (332) alignment
Range on Protein: 78-198
Range on HMM: 34-155/332.0
KLDAQQD-SSLTFEAFKQNMHKNrYSDVVCRDTTRVKLTIDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEGR
.|| .|   | .  |  .....|   ..| .|   |.||  .   . || |  .. . . . .| |  . .  .  ||.|...... .|..| . .|.. 
dlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkl

PKCVGYWPSLG-VTETYGCIRVT
 |   |.|  .     .| . |.
eksdkyfpdktreelkfGildve

PTEN_1 200-324 1e-10 36.7 In-house 62-184 (196) alignment
Range on Protein: 200-324
Range on HMM: 62-184/196.0
MGESSDEFEICNLAVTFVPdnvpvDEQPANLKELRVNLIK--WPNWPDRGVPDEKCHTVPQRLLAQV-R----HGPCVVHCSAGIGRTGCVVALEFAYNK
. .... . ..||.  .        ... .|.| . . ..     ..| |.|.  ..    . ...  .    .. ..||| ||.||.|.|||    | .
nlkedgitlvvnlseeeel.....sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykg

LdrglkVDFEEIITELRKQR-AQCIQTEIQYLY
       ...| .  .|..| . ....  |  .
k.....ltadeAlelvrekRppgapnspsqerl

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 84-198 2.4e-10 34.5 In-house 84-194 (244) alignment
Range on Protein: 84-198
Range on HMM: 84-194/244.0
DSSLTFEAFKQ-NMHKNRYSDVVCRDTTRVKLTiDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFqERAESILMLCKTMEEGRpkcvGY
| |.  .||.  | .||| .  .  |  || |.   |  . || | .|        .| || ||  | .|||.|.. ||   .|..  ..||       |
dpsvmkdafnpnnswknregaglpfdfnrvpls.kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmml.erhvnvlvvlgsveeed....ey

WPSLGVTETYGC-IRVT
||     | |   | ||
wpdseplewyeeditvt

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 87-175 5.1e-10 33.3 In-house 26-113 (332) alignment
Range on Protein: 87-175
Range on HMM: 26-113/332.0
LTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDKSRyEDYIHANYVKTNYLRNTFICTQGPL-QHTIIDFWRMIFqERAESILMLCKTMEEG
 |.. | .||  ||   . | | .||.|. .  . .|.  |..|     ....| .| |. .||   ||||.  ||  |....   ..| 
ntydkflnnmdmnriphlycfdhsrvelapqdgk.ddfynaswvdgyskksayifaqapfndhteyvfwrmvs.erkpsmilvfgdidek

subfamily_PTPDC1_pd Subfamily PTPDC1 261-326 9.1e-10 33.3 In-house 109-169 (182) alignment
Range on Protein: 261-326
Range on HMM: 109-169/182.0
LAQVRHGPCVVHCSAGIGRTGCVVALEFAYNKldrglKVDFEEIITELRKQRAQCIQTEIQYLYIH
   ...|   ||| || |||| ..|  . |.|     ... |. |. .|..|...|||  |   ..
afalqegkvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvk

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 136-201 1.2e-09 32.0 In-house 235-297 (440) alignment
Range on Protein: 136-201
Range on HMM: 235-297/440.0
RNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEEgrpKCVGYWPSLGVTETYGCIRVTNMG
.|.||.|| ||. |..||||.. . |  .|.|| .  .     |  |||    . |.| . |   |
knafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkg

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 270-330 7.6e-09 29.9 In-house 2-62 (69) alignment
Range on Protein: 270-330
Range on HMM: 2-62/69.0
VVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVMI
|||||.| ||||  .|.     ..     ||  . .  .|| |   .  ||.|..||  ..
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv

0038934 (Phosphotyrosine protein) phosphatases II 230-322 9.7e-09 30.6 In-house 75-166 (194) alignment
Range on Protein: 230-322
Range on HMM: 75-166/194.0
LKELRVNLIKWPN-----WPDRGVPDEKCHTVPQRLlAQVRHGPCVVHCSAGIGRTGCVVALEFAYNkldrgLKVDFEEIITELRKQRAQCIQTEIQY
.... .  .|.|       |.  . .. .. | . | ..  .| ..||| ||.||||..||    |      |. . || |  .|  |  .|..  ..
fekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyl

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 264-332 1.4e-08 28.8 In-house 260-343 (350) alignment
Range on Protein: 264-332
Range on HMM: 260-343/350.0
VRHGPCVVHCSAGIGRTGCVVALEFAYN-------------KLDRGLKV--DFEEIITELRKQRAQCIQTEIQYLYIHRVMIAF
 |  | .||||||.|||| .|.|..  .             |||.  |.    . |. |||||| . .|.  |...|.  .  .
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 270-329 1.3e-07 25.8 In-house 1-60 (69) alignment
Range on Protein: 270-329
Range on HMM: 1-60/69.0
VVHCSAGIGRTGCVVALEFAYNKLDRGLKVDFEEIITELRKQRAQCIQTEIQYLYIHRVM
|||||.| ||||  .|.     ..     ||  . .  .|| |   .  | .|..||  .
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 81-144 2.6e-07 24.7 In-house 34-95 (95) alignment
Range on Protein: 81-144
Range on HMM: 34-95/95.0
AQQDSSLTFEAFKQNMHKNRYSDVVCRDTTRVKLTIDksRYEDYIHANYVKTNYLRNTFICTQG
    .. |  . . |. |||. ...  |.||| ||    |  ||| | .|     .| .|..||
mtsgapytvgsseanipknrflnifpydatrvvlttk..rdsdyinacfvdgyarkncyiaaqg

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 116-208 3.2e-07 24.7 In-house 7-93 (130) alignment
Range on Protein: 116-208
Range on HMM: 7-93/130.0
IDKSRYEDYIHANYVKTNYLRNTFICTQGPLQHTIIDFWRMIFqERAESILMLCKTMEEGRpkcvGYWPSLGVTETYGCiRVTNMGESSDEFE
... . ..||.|..|      . .. || ||  | .|||.|.. ||   .|..  ..||       |||     | |   ...      |||.
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmml.eryvnvlvvlgsveeed....eywpdsePlewyee.diivtltdrdefk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 265-332 2.3e-06 21.2 In-house 264-343 (349) alignment
Range on Protein: 265-332
Range on HMM: 264-343/349.0
RHGPCVVHCSAGIGRTGCVVALEFAYN----------KLDR-GLKVDF-EEIITELRKQRAQCIQTEIQYLYIHRVMIAF
.  . .|||||| |||| .| |..  .          |..   |. |    |. |||||| . .|   |.  |.  .. .
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLky

subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 79-174 4.4e-06 18.4 In-house 13-101 (275) alignment
Range on Protein: 79-174
Range on HMM: 13-101/275.0
LDAQQDSSLTFEAFKQNMHKNRYSDVVCRDTtrvklTIDKSRYEDYIHANYVKTNYlrNTFICTQGPLQHTIIDFWRMIFQERAESILMLCKTMEE
||  .      | | .| .|||...|.| |       .|.   | ..||| ..| |    |. .| | . |  |. ....    .... |    | 
lddlnlddekierfirngeknrftnvtcfde.....ildrenqeffvhantfrtpy..gnflisqapndstnadhlhllwiynvqtvvclvlpeea

TetR_C_9 Transcriptional regulator, TetR, C-terminal 307-352 8.2e-06 13.1 Pfam-A 7-50 (129) alignment
Range on Protein: 307-352
Range on HMM: 7-50/129.0
ELRKQRAQCIQTEIQYLYIHRVMIAFARGETDVSEKALAaaDAFLK
 ||.  ...|.|  .| |..|...|  | ...   . .|  | .|.
klrrhlskvidtyfkyPylnrllaalvrdsdeeearria..dkyle