Gene Y5F2A.3 in Caenorhabditis elegans

Synonym: CELE_Y5F2A.3, Y5F2A.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP224_AA protein Get Run
CeleP224_AA_89-289 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 92-287 1.2e-49 164.7 In-house 52-282 (308) alignment 
Range on Protein: 92-287
Range on HMM: 52-282/308.0
FERTPPEEHKTYAFQANREKNRNPDFPLYDVTRVRLkteaEDEKNYINASITSCP--PCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ--
.. .|..| .......|..||| .|.. || .||.|    ... .|||||  ...   ..||.|..|.|... .| ||.||. |.. ||  . ...|   
lsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengr

--LPMYFPTE-----------------------------------HGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDkvTKGKCLIHSAEGINR
   . |.|.|                                    |. |..|..||..|| ..| |||. .|. .  .. |    .|....|.  |..|
ekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGR

SMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGAL
.. |||.|...|.. ....||..|.. .||.|| |. 
tGtfialdllleqlekeggvdvfeavkklReqRpgmv
0036941 (Phosphotyrosine protein) phosphatases II 92-288 1.6e-49 164.2 In-house 23-261 (297) alignment 
Range on Protein: 92-288
Range on HMM: 23-261/297.0
FERTPPEEHKTYAFQANREKNRNPDFPLYDVTRVRLkteAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ----
... .. . .......|.|||| .|.. || |||.|    ... .|||||  ... ..||.|..|.|... .| ||.||. | . ||  . ...|     
lpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrek

LPMYFPTE------------------------------------HGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKV--TKGKCLIHSAEGIN
 . |.|.|                                     |. |..|..||..||  .| .||. .|. |  ..   |    .|. |.|.  |..
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvg

RSMSFIAVDYIIELMF---RNNTVDIPELITQLRSQRGGALP
||..|||.|......    ....|||.|.. .||.|| || .
RsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq
0047943 (Phosphotyrosine protein) phosphatases II 90-288 9.6e-49 161.6 In-house 21-256 (273) alignment 
Range on Protein: 90-288
Range on HMM: 21-256/273.0
SsFERTPPEEHKTYAFQANREKNRNPDFPLYDVTRVRLkteAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ--
  .. .|. . .......|..|||..|.. || .||.|    ... .|||||  ......||.|..|.|... .| ||.||. | . ||  . ...|   
l.lslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgr

--LPMYFPTEHG-----------------------------------NARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKV--TKGKCLIHSAEGI
   . |.|.| |                                   . |..|..||..||  .| ||.. .|. |  ..   .    .|. ..|.  |.
ekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGv

NRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGALP
.|...|||.|...... ....||..|.. .||||| |. .
gRtgtfialdllldqlekeggvdvleavkllrsqRpgmvq
0040438 (Phosphotyrosine protein) phosphatases II 93-289 3.7e-48 159.8 In-house 28-261 (317) alignment 
Range on Protein: 93-289
Range on HMM: 28-261/317.0
ERTPPEEHKTYAFQANREKNRNPDFPLYDVTRVRLKTEAED-EKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ----
 . .... .......|..|||.||...|| .||.|. . .| . .|||||  ..| . ||.|..|.|... .| ||.||. | . ||  . ...|     
lslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrek

LPMYFPT--------------------------------EHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFI
   |.|.                                .... |..|..||..|| ..| |||. .|. .  .. . .  .|..|.|.  |..|...||
caqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfi

AVDYIIELMFRNNTVDIPELITQLRSQRGGALPR
|.....|.. ....||..| . .||.||.|| . 
aaylmleqlekeggvdveeavkelreqRpgavqt
0051299 (Phosphotyrosine protein) phosphatases II 94-288 6e-48 159.1 In-house 35-270 (288) alignment 
Range on Protein: 94-288
Range on HMM: 35-270/288.0
RTPPEEHKTYAFQANREKNRNPDFPLYDVTRVRLKTEAE-DEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ----L
 .|. . .......|.||||..|.. || .||.|... . .. .|||||  ......||.|..|.|... .| ||.||. |.. ||  . ...|      
llpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekc

PMYFPT------------------------------------EHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSM
. |.|.                                     .|. |..|..||..||  .| .||. .|. .  .. . . ..| ...|.  |..|..
aqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtg

SFIAVDYIIELMFRNNTVDIPELITQLRSQRGGALP
 |||.|...|.. ....||..|.. .||.|| |. .
tfialdllleqlekeggvdvleavkrlreqRpgmvq
0046845 (Phosphotyrosine protein) phosphatases II 96-287 6.5e-46 152.3 In-house 16-257 (284) alignment 
Range on Protein: 96-287
Range on HMM: 16-257/284.0
PPEEHKTYAFQANREKNRNPDFPLYDVTRVRLKTEAE--DEKNYINASITSCP-----PCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDE--
.  . .......|..||| .|.. || .||.||.. .  .. .|||||  ...      ...|.|..|.|... .| ||.||. |.. ||  . ...|  
lllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelveng

--QLPMYFPTE----------------------------------HGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDK--VTKGKCLIHSAEGI
  . . |.|.|                                   |. |..|..||..||  .| |||. .|. .  .. . .   ..|. ..|.  |.
rekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGv

NRSMSFIAVDYIIELMFRNN---TVDIPELITQLRSQRGGAL
.|.. |||.|...|.. ...   .||..|.. .||.|| |. 
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmv
0039614 (Phosphotyrosine protein) phosphatases II 96-288 7.1e-46 152.4 In-house 45-273 (297) alignment 
Range on Protein: 96-288
Range on HMM: 45-273/297.0
PPEeHKTYAFQANREKNRNPDFPLYDVTRVRLKTEAE--DEKNYINASITSCPPC-ERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ---LP
.|.  .......|..||| .|.. || .||.||.| .   . .|||||  ... .  ||.|..|.|..| .| ||.||. | . ||  . ...|     .
kpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkca

MYFPTEHGNARFITI-----------------------------LHYPHWPKGHVAPSPKVILRGIYSLQPSDKV--TKGKCLIHSAEGINRSMSFIAVD
 |.|.| |.   .|.                             ..|..|| ..| ||....|. .  ..   .    .|..|.|.  |..|. .||| .
qywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaay

YIIELMFRNNTVDIPELITQLRSQRGGALP
...|.. .. .||..| . .||.||.|| .
lmleqlekeggvdvleavkelreqRpgavq
0045450 (Phosphotyrosine protein) phosphatases II 92-288 1.3e-45 151.9 In-house 39-288 (307) alignment 
Range on Protein: 92-288
Range on HMM: 39-288/307.0
FERTPPEEHKTYAFQANREKNRNPDFPLYDVTRVRLKTEAE--DEKNYINASIT--------SCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAI
.. ... |........|..||| .|...|| |||.|... .  .. .|||||          ... . ||.|..|.|..| .| ||.|.. | . ||  .
vtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivml

FSPDEQ----LPMYFPTE----------------------------------HGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKV--TKGKCL
 ...|      ..|.|.|                                   |. |..|..||..|| ..| ||.. .|. |  ..   .    .|..|
telvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvl

IHSAEGINRSMSFIAVDYIIELMFRNNT---VDIPELITQLRSQRGGALP
.|.  |..|...||| ....... ...|   ||..| . .||.||.|| .
VHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavq
0043336 (Phosphotyrosine protein) phosphatases II 92-288 2.4e-44 147.3 In-house 29-261 (278) alignment 
Range on Protein: 92-288
Range on HMM: 29-261/278.0
FERTPPEEHKTYAFQANREKNRNPDFPLYDVTRVRLKTEAEDE-KNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDE----
. . .... .......|..||| .|...|| .||.|. . .|.  .|||||  ..... ||.|..|.|..| .| ||.||. . . .|  . ...|    
llsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrv

QLPMYFPT-------------------------------EHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFI
.   |.|                                 .|. |..|..||..|| ..| .|.. .|. .  ..   .  .|. |.|.  |..|.. ||
kcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfi

AVDYIIELMFRNNTVDIPELITQLRSQRGGALP
|.....|.. .. .||..| . .||.||.||..
alyllleqlekeggvdleeavkelreqRpgavq
0040439 (Phosphotyrosine protein) phosphatases II 100-288 3.9e-41 136.7 In-house 3-230 (249) alignment 
Range on Protein: 100-288
Range on HMM: 3-230/249.0
HKTYAFQANREKNRNPDFPLYDVTRVRLKTEAE-DEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ----LPMYFPT
 ... ...|..|||.||.. || .||.|.   .    .|||||  ... . |..|..|.|..| .| ||.|.. . | ||  . |..|        |.|.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

--------------------------------EHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKV--TKGKCLIHSAEGINRSMSFIAVDYI
                                ..|. | .. ..|..||  .| ||.. .|. |  ..   .   ..|..|.|.  |..|.  ||| ...
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

IELMFRNNTVDIPELITQLRSQRGGALP
.|.. ....||..| . .|||||.|| .
leqlekelgvdleeavkllrsqRpgavq
0042113 (Phosphotyrosine protein) phosphatases II 101-288 1.1e-39 131.7 In-house 2-227 (245) alignment 
Range on Protein: 101-288
Range on HMM: 2-227/245.0
KTYAFQANREKNRNPDFPLYDVTRVRLKTEAEDE-KNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ----LPMYFPT-
.......|..|||..|...|| |||.|. . .|.  .|||||  ... . .|.|..|.|..| .| ||.|.. . | .|. . ...|      . |.|. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

-------------------------------EHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDK-VTKGKCLIHSAEGINRSMSFIAVDYIIE
                                ..  |... .|| .|| ..|..... .|. .  ..   .   .|..|.|.  |..|.. |||.....|
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

LMFRNNTVDIPELITQLRSQRGGALP
.. .. .|...| . .|||||.|| .
qlekelgvsleeavkelrsqRpgavq
0045098 (Phosphotyrosine protein) phosphatases II 96-288 7.2e-39 129.2 In-house 21-256 (278) alignment 
Range on Protein: 96-288
Range on HMM: 21-256/278.0
PPEEHKTYAFQANREKNRNPDFPLYDVTRVRlkteaedekNYINASITSCPpcERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ----LPMY
.| |  .. .  |..||| .|.. || .||.         .|||||  ...   .|.|..|.|...  . ||.|.. . | ||  . .  |      ..|
ipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

FPT------------------------------------EHGNARFITILHYPHWPKGHVAPSP--KVILRGIYSLQPSDKV-------------TKGKC
.|                                     |..  |..|.|||..|| ..| ..|  | .|. .  ..   |.              .|..
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

LIHSAEGINRSMSFIAVDYIIELMfrNNTVDIPELITQLRSQRGG-ALP
|.|   |..|.  ..|.....||.  ...||..| ...|||||.| |..
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavq
0037934 (Phosphotyrosine protein) phosphatases II 102-288 1.7e-34 114.8 In-house 4-226 (243) alignment 
Range on Protein: 102-288
Range on HMM: 4-226/243.0
TYAFQANREKNRNPDFPLYDVTRVRLkteaEDeKNYINASITSCPPcerKWIVAQHPMKEYYEY----FWKMVFYQEIDVIFAIFSPD----EQLPMYFP
.. ...|..||| .|...|| .||.|    |.  .||||. . ..|   ..|. |.|..| .|     ||.|.. . |.||  . ...    |. ..|.|
iallpenlsknrysdilpydhsrvkl....eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

------------------------------T-EHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPS--------DKVTKGKCLIHSAEGINRSMSF
                              . . .  |... .||  || ..| .||. .|. .  ..             ..|..|.|   |..|.  .
gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

IAVDYIIELMfrnnTVDIPELITQLRSQRGG-ALP
|| .....|.    .||. | . .||.||.| | .
iaaylmllll....gvdleeavkllreqRpgkavq
0049772 (Phosphotyrosine protein) phosphatases II 90-288 8e-27 90.2 In-house 28-258 (314) alignment 
Range on Protein: 90-288
Range on HMM: 28-258/314.0
SSFERTPPEEHKTYAFQANREKNRNPDFPLYDvTRVRLKTEAEDEKNYINASITSCPpceRKWIVAQHPMKEYYEYF----------WKMVFYQEIDVIF
 | . .|.  .... . .||.|||..|.. .| .||.|...  .  .|||||  ...   .|.|..|.|...... |          |.||......|. 
rslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrd

AIF---------------------SP------DEQLPMYFP--------TEHGNARFITILHYpHWPKgHVAPSPKVILRGIYSLQPSdkVTKGKCLIHS
                         .      .|  .....         |.   . |. |.. ..|  . ||... ... .  ..     ..|. |.| 
ivmsrdevladelsrLdaAlgKtpllildgngneptaadlellkeelydpelferlgikylri.pvpD.gsaplledfdeflefieea..dkggpvlvHC

AEGINRSMSFIAVDYIIELMfrnnTVDIPELITQLRSQRGgALP
. |..|. .|....|.. |.     |.. | . ..|..|  . |
kaGkgRtgtfvvaaylmkll....gvsleealedvrlkRp.inp
DSPc_SM00195 94-196 8.5e-25 82.9 In-house 12-119 (263) alignment 
Range on Protein: 94-196
Range on HMM: 12-119/263.0
RTPPEEHKTYAFQANREKNRNPDFPLYDVTRVRLKTEAE-DEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDE----QL
 |.|.| .. ....|..|||  ....|| |||.||.| . ....||||.. ... ...|.|..|.|...  | ||.||. ... .|  .....|    . 
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

PMYFPTEH
  |.| | 
drywpees
PTPc_SM00194 94-196 8.5e-25 82.9 In-house 12-119 (263) alignment 
Range on Protein: 94-196
Range on HMM: 12-119/263.0
RTPPEEHKTYAFQANREKNRNPDFPLYDVTRVRLKTEAE-DEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDE----QL
 |.|.| .. ....|..|||  ....|| |||.||.| . ....||||.. ... ...|.|..|.|...  | ||.||. ... .|  .....|    . 
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

PMYFPTEH
  |.| | 
drywpees
Y_phosphatase Protein-tyrosine phosphatase 108-196 4.6e-22 73.9 Pfam-A 1-92 (235) alignment 
Range on Protein: 108-196
Range on HMM: 1-92/235.0
NREKNRNPDFPLYDVTRVRLKTEAEDEKnYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDE----QLPMYFPTEH
|..|||..|.. || |||.|| . .... ||||.. .  . ..|.|..|.|.|.  | ||.||. ... ||. . | .|    ... |.|.| 
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee
Y_phosphatase Protein-tyrosine phosphatase 108-196 4.6e-22 73.9 In-house 1-92 (235) alignment 
Range on Protein: 108-196
Range on HMM: 1-92/235.0
NREKNRNPDFPLYDVTRVRLKTEAEDEKnYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDE----QLPMYFPTEH
|..|||..|.. || |||.|| . .... ||||.. .  . ..|.|..|.|.|.  | ||.||. ... ||. . | .|    ... |.|.| 
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeee
0041856 (Phosphotyrosine protein) phosphatases II 108-286 4.9e-22 73.8 In-house 1-153 (182) alignment 
Range on Protein: 108-286
Range on HMM: 1-153/182.0
NREKNRNPDFPLYDVTRvrlkteaedEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFspdeqLPMYFPTEHgnARFITILHY
|..||| .|.. || .|           .||||..  ..   ...|..|.|... .. |..|.  . | .|  .       ..|.|..    | .. ..|
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywpell..erlgiqyly

PHWPKGHVAPsPKVILRGIYSLQPsdkvTKGKCLIHSAEGINRSMSFIAVDyiieLMFRNNtVDIPELITQLRSQRGGA
  || ..| . .  .|. |   .      .|..|.|   |..|. ...| .    || ... |...| . ..||.| |.
lpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaay....lmkklg.vsleeavklvrsrRpgm
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 100-197 2.6e-18 60.5 In-house 43-143 (302) alignment 
Range on Protein: 100-197
Range on HMM: 43-143/302.0
HKTYAFQANREKNRNPDFPLYDVTRVRLKTEAedeKNYINASITSCPPCERKWIVAQHPMKEYY---EYFWKMVFYQEIDVIFAIFSPDEQ---LPMYFP
 |  ||..| .||...|.|..| ..|.|..|.   ..|.||| .. | ..|. |.|| | ..     | ||.||| ..|  .. .  ..|    |  .||
ekCkafkknlkknqsedvpildsnlvkleaep...dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfp

TEHG
.. |
kksg
0036282 (Phosphotyrosine protein) phosphatases II 136-289 5.2e-18 60.8 In-house 3-155 (174) alignment 
Range on Protein: 136-289
Range on HMM: 3-155/174.0
NYINASITSCPPCERKWIVAQHPMKeyyeyFWKMVFYQEIDVIFAIFSPDEQL----PMYFPT-EHGNARFITILHYPHWPKGHVAPSPKvILRGIYSLQ
.|||||  .   . ...|. |.|..     ||.|.. . | ...   .. |      . |.|.  .   |..  ..| .|| ..| .... .|. .  ..
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfve

PSDKV-TKGKCLIHSAEGINRSMSFIAVDYIIELMFrNNTVDIPELITQLRSQRGGALPR
   .   .|..|.|   |..|.  ..| .... ... ...||. .|. .||.||.|. ..
ealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt
Y_phosphatase Protein-tyrosine phosphatase 199-287 1.7e-17 59.0 Pfam-A 132-220 (235) alignment 
Range on Protein: 199-287
Range on HMM: 132-220/235.0
ARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGAL
 | .. ||| .||.  |  ||| .|. | ... | . ..|....|. .|..|...|.|.|...| . ....||. ... .||.|| |. 
krevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmv
Y_phosphatase Protein-tyrosine phosphatase 199-287 1.7e-17 59.0 In-house 132-220 (235) alignment 
Range on Protein: 199-287
Range on HMM: 132-220/235.0
ARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGAL
 | .. ||| .||.  |  ||| .|. | ... | . ..|....|. .|..|...|.|.|...| . ....||. ... .||.|| |. 
krevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmv
0043147 (Phosphotyrosine protein) phosphatases II 133-288 3.2e-17 58.2 In-house 3-145 (172) alignment 
Range on Protein: 133-288
Range on HMM: 3-145/172.0
DEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPdeqlpmyFPTEHGNARFITILHYPHWPKGHVApSPKVILRGIYSLQP-
.  .|||||  ... . ...|. | |. .... ||.|.  . |..|. . .        . .  .  |..  ..|  || ..|  .....|. .  ..  
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.......lydpellerlgiqylylpwpDhgvp.llellleflefidel

SDKVTKGKCLIHSAEGINRSMSFIAVDYIIelmfrnNTVDIPELITQLRSQRGGALP
  .  .|..|.|   |..|.  ..| ....        ... | . ..|..|.|| .
lalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq
subfamily_PTPRD_pd Subfamily PTPRD 92-198 1.3e-16 55.3 In-house 32-142 (564) alignment 
Range on Protein: 92-198
Range on HMM: 32-142/564.0
FERTPPEEHKTYAFQANREKNRNPDFPLYDVTRVRLK-TEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ---
.|. . .. .. . .||..|||  .   || .||.|. .|.... .|||||       ....| .|.|..|  | ||.||. |.. .|  . .  |.   
ieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkv

-LPMYFPTEHgN
 . .|.|... .
kchkYWPekg.t
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 97-196 1.5e-16 55.5 In-house 45-149 (298) alignment 
Range on Protein: 97-196
Range on HMM: 45-149/298.0
PEEHKTYAFQANREKNRNPDFPLYDVTRVRLKT-EAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDE----QLPMY
 ||..    ..|..||| .|   .| .||.|.. .|..| .|||||  .    .  .|..|.|..|  | ||.||  ..| .|  . .  |    . . |
eeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhky

FPTEH
.|.|.
wPdeg
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 106-283 1.9e-16 54.5 In-house 43-215 (392) alignment 
Range on Protein: 106-283
Range on HMM: 43-215/392.0
QANREKNRNPDFPLYDVTRVRL-KTEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQLpmyfptEHGNARFITI
. | .|||  .   || .||.|   .   ...|.|||   .  .|. .| .| |     . ||.||| ...  |  .   .|           .|| .. 
einlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......kgddartvaq

LHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQR
 |.  ||   |      .|. |  ..          .|| . |. |.   |..| ..    .   ||. ...|..| .|
fhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkr
subfamily_PTPN14_pd Subfamily PTPN14 100-183 2.1e-15 51.5 In-house 41-126 (300) alignment 
Range on Protein: 100-183
Range on HMM: 41-126/300.0
HKTYAFQANREKNRNPDFPLYDVTRVRLKTEAEDEKNYINASITSCP--PCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFS
 .| . . | |||| .|.  |. .||.|..  |....|||||  . .    ||..|||| |..   . ||.||. |....|  . .
lstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlte
subfamily_PTPN23_pd Subfamily PTPN23 104-199 3.1e-15 50.8 In-house 39-136 (288) alignment 
Range on Protein: 104-199
Range on HMM: 39-136/288.0
AFQANREKNRNPDFPLYDVTRVRLKTEAEDeknYINAS-ITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQLPM----YFPTEHGN
. . . ||||. |   || .|| |. . .|   ||||| . .  |   ..|..| |...    ||.||. |   ||  . |..|.       |.|...|.
iaklyseknrsrdilPyDhnRvklrgskDD...YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkge

A
.
t
DSPc_SM00195 197-286 3.5e-15 51.4 In-house 155-244 (263) alignment 
Range on Protein: 197-286
Range on HMM: 155-244/263.0
GNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGA
 ..|..| ..|  ||.  |  |.| .|. . ... | . ..| ...|.  |..|. .|...|.|.. . ....||| |....||.|| |.
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgm
PTPc_SM00194 197-286 3.5e-15 51.4 In-house 155-244 (263) alignment 
Range on Protein: 197-286
Range on HMM: 155-244/263.0
GNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGA
 ..|..| ..|  ||.  |  |.| .|. . ... | . ..| ...|.  |..|. .|...|.|.. . ....||| |....||.|| |.
eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgm
subfamily_PTPRG_pd Subfamily PTPRG 106-196 3.9e-15 50.1 In-house 45-141 (563) alignment 
Range on Protein: 106-196
Range on HMM: 45-141/563.0
QANREKNRNPDFPLYDVTRVRLKTEAEDEKN--YINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFS----PDEQLPMYFPTEH
. |..|||. .   || .||.|.  .. .|.  ||||.       ....|..|.|.|.  . ||.|.. |.  .|  |        .. ..|.|...
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkde
PTPc_DSPc_SM00012 202-286 3.9e-15 51.3 In-house 2-89 (105) alignment 
Range on Protein: 202-286
Range on HMM: 2-89/105.0
ITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTK--GKCLIHSAEGINRSMSFIAVDYIIELMFRN-NTVDIPELITQLRSQRGGA
.. .||. ||. .|  ... ||. . ... . .  .  . ...|.  |..|.  |.|.|.... . .. ..||| ... .||.|| |.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgm
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 96-183 7.8e-15 49.7 In-house 35-122 (318) alignment 
Range on Protein: 96-183
Range on HMM: 35-122/318.0
PPEEHKTyAFQANREKNRNPDFPLYDVTRVRLKTE-AEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFS
 . ..|.   ..|. |||  .   || |||.|..   | . .||||.       ....| || |. |  | ||.||. |.  ||  .  
tvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 107-197 8.3e-15 49.7 In-house 8-102 (250) alignment 
Range on Protein: 107-197
Range on HMM: 8-102/250.0
ANREKNRNPDFPLYDVTRVRLKTEA-EDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFS---PDEQLPMYFPTEHG
.|.||||  |.  .| .|| |..|  ..| .|||||       .. .|..|.|...  | ||.||. .....|  . .    ... . |.|.|. 
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPveka
0046846 (Phosphotyrosine protein) phosphatases II 136-288 9.5e-15 50.3 In-house 13-157 (176) alignment 
Range on Protein: 136-288
Range on HMM: 13-157/176.0
NYINASITSCPpcerKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQL----PMYFPTEHG--NarfitILHYPHWPKGHVAPSpKVILRGIYSL
.||||..  ..    ..|. |.|. . .. |..|.. . |.... . .. |      | |.| ...          .. .|| ..| .. . .|. .  .
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....qylhlpwpDhgvpdl.elllellefi

QPSDKvTKGKCLIHSAEGINRSMSFIAVDyiieLMFRNNTVDIPELITQLRSQRG-GALP
.   |  .|. |.|   ||.|.  ..| .    |. ... ... | . ..|.||  ||..
realk.eggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq
subfamily_Ptp69D_pd Subfamily Ptp69D 101-195 1.8e-14 48.6 In-house 41-140 (307) alignment 
Range on Protein: 101-195
Range on HMM: 41-140/307.0
KTYAFQANREKNRNPDFPLYDVTRVRLK-TEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSP----DEQLPMYFPTE
|. . . |  ||| .|   .| |||.|| .. ... .|||||       ..|.|.|| |. .  . ||.|.  ||. .|  .       ... . |.| |
kvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie
subfamily_PTPRB_pd Subfamily PTPRB 105-181 1.9e-14 48.4 In-house 48-125 (293) alignment 
Range on Protein: 105-181
Range on HMM: 48-125/293.0
FQANREKNRNPDFPLYDVTRVRLK-TEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAI
 ..||.|||  .   || .||.|. .. |....||||.  .   ..|..|..| |. |  . ||.||. ..  .|  .
lavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivml
subfamily_PTPN1_pd Subfamily PTPN1 103-178 2.2e-14 47.8 In-house 27-99 (290) alignment 
Range on Protein: 103-178
Range on HMM: 27-99/290.0
YAFQANREKNRNPDFPLYDVTRVRLKTEAEdekNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVI
  ...||..||  |   || .|..|. .     .|||||.   .  .|..|..| |. .  ..||.||. |.   .
aklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskav
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 105-181 4.2e-14 47.3 In-house 44-121 (288) alignment 
Range on Protein: 105-181
Range on HMM: 44-121/288.0
FQANREKNRNPDFPLYDVTRVRLKT-EAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAI
   | .||| ..   || .||.||  | |....|||||       ..|.| .| |. .  . ||..|. ...  |  .
lavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 106-180 4.9e-14 47.1 In-house 39-114 (281) alignment 
Range on Protein: 106-180
Range on HMM: 39-114/281.0
QANREKNRNPDFPLYDVTRVRL-KTEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFA
..|..|||  .   || |||.. ..|.. . .||||.  .    |...|..| |. .  . ||.||. |....|  
denvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivm
0049260 (Phosphotyrosine protein) phosphatases II 150-288 4.9e-14 47.8 In-house 9-134 (152) alignment 
Range on Protein: 150-288
Range on HMM: 9-134/152.0
RKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQLPMYFPTEHgnarfitILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGIN
.. | .|.|. . .. ||.|.  . |..|  . ...|    ...            ..  || ..| ... ..|  .  ..   .  .|..|.|   |..
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.......qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvg

RSMSFIAVDYIIelmfrnNTVDIPELITQLRSQRGGALP
|.  ..| ....      . |.. | . ..|..| || |
Rtgtlvaaylml......lgvsleeavalvrekRpgavp
subfamily_PTPRK_pd Subfamily PTPRK 104-179 1.8e-13 45.0 In-house 39-115 (314) alignment 
Range on Protein: 104-179
Range on HMM: 39-115/314.0
AFQANREKNRNPDFPLYDVTRVRLKTEAED-EKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIF
  . ||||||  |   || .||.|.|  .| . .||||...      ...||.|.|..|  . ||..|. ..   | 
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasiv
subfamily_PTPN12_pd Subfamily PTPN12 106-179 2.7e-13 44.4 In-house 38-112 (290) alignment 
Range on Protein: 106-179
Range on HMM: 38-112/290.0
QANREKNRNPDFPLYDVTRVRLKTEAEDE-KNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIF
. |..|||  |   || .|| |... |.| ..||||..   .  . ..| || |. .  . ||.|...... .. 
eenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivv
subfamily_CG7180_pd Subfamily CG7180 107-191 3.2e-13 44.0 In-house 41-126 (296) alignment 
Range on Protein: 107-191
Range on HMM: 41-126/296.0
ANREKNRNPDFPLYDVTRVRLKT-EAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQLPMY
 ||||||...   || .|| |.. . |....||||.       ....|| . |.||  . ||..|. .||. .  .  . ..  ||
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmy
subfamily_PTPRD_pd Subfamily PTPRD 197-284 1.1e-12 42.4 In-house 174-261 (564) alignment 
Range on Protein: 197-284
Range on HMM: 174-261/564.0
GNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
 ..| ..  |. .||   |  |.. .|. |   . . . ..|  ..|   |. |.  ||..|...| .  ..|||| . ...||.|| 
sesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRn
subfamily_PTPN9_pd Subfamily PTPN9 101-181 1.3e-12 42.4 In-house 35-116 (297) alignment 
Range on Protein: 101-181
Range on HMM: 35-116/297.0
KTYAFQANREKNRNPDFPLYDVTRVRLKTEAEDE-KNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAI
..   .|| ||||  |   || ||| |... |||  .||||. .     .. .| .| |.|. .. ||.||. ||. ||  .
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt
0051429 (Phosphotyrosine protein) phosphatases II 135-288 1.4e-12 43.3 In-house 4-209 (272) alignment 
Range on Protein: 135-288
Range on HMM: 4-209/272.0
KNYINASITSCPPC---ERKWIVAQHPMKEYYEYFWKMvFYQEIDVIFAIFSPDEQL----PMYFP---------------T------------------
 .||||.  . .     ... . ...|..   . ||..   . |..|. . |..|.     ..| |               |                  
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

------------EHGNARFITILHYPHWPKGHVAPSPkviLRGIYSLQ-PsdkvtKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVD--------IP
              |.|| ...|||  ||  .|....   |. . .|        .|..|.| . |..|.  ..|...... . ..  ||        . 
yilrellltlllsagearevmhlhytdwpdhgvpqea...llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

ELITQLRSQRGGALP
| . .||.|| || .
eaveelraqrpgavq
subfamily_PTPN3_pd Subfamily PTPN3 103-179 2.9e-12 41.1 In-house 36-113 (280) alignment 
Range on Protein: 103-179
Range on HMM: 36-113/280.0
YAFQANREKNRNPDFPLYDVTRVRLKTEAED--EKNYINASITSCPpCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIF
    .| .|||  |   || |||.|| .  |  . ||.|  | |      ..|..| |...  . ||.||. |.. .| 
arkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstg.lvnryiatqGPlaktatdfWqmvweqkssliv
0044763 (Phosphotyrosine protein) phosphatases II 152-289 4.3e-12 41.5 In-house 30-156 (178) alignment 
Range on Protein: 152-289
Range on HMM: 30-156/178.0
WIVAQHPMkeyyEYFWKMVFYQEIDVIFAIFSPDEQL----PMYFPTEHGnarfITILHYpHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEG
 .....|.    . .....  . |..|  . ...|      . |.|.|.|    |. ||. ..| ..| .... .|. .  ..   .  .|..|.|   |
lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag....iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaG

INRSMSFIAVDYIIELmfrnnTVDIPELITQLRSQRGgALPR
..|| ...| .....|      ....| | ..|..|  . |.
vgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpn
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 101-181 5.2e-12 40.4 In-house 36-113 (288) alignment 
Range on Protein: 101-181
Range on HMM: 36-113/288.0
KTYAFQANREKNRNPDFPLYDVTRVRLKteaEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAI
   .| ||  ..|  . |  |.|||.|.   .| . ||.| . |. . .|. | || |..   | .|||.. .... |  .
iidsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivml
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 197-284 6.3e-12 40.1 In-house 172-259 (288) alignment 
Range on Protein: 197-284
Range on HMM: 172-259/288.0
GNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
.. . || ..|  ||   |  | . .|  .. .. ...   |. ..| ..|. |.  |||.| .|. . .....|. . ...|| || 
kteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRa
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 105-182 7.2e-12 40.1 In-house 43-121 (305) alignment 
Range on Protein: 105-182
Range on HMM: 43-121/305.0
FQANREKNRNPDFPLYDVTRVRLKTEAEDE-KNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIF
 .||..|||. .  |.|  |..|... ... ..|||||       . |.|||| |.|.  . ||....   . .|  . 
keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmlt
subfamily_egg_pd Subfamily egg 102-196 7.6e-12 39.5 In-house 33-131 (307) alignment 
Range on Protein: 102-196
Range on HMM: 33-131/307.0
TYAFQ-ANREKNRNPDFPLYDVTRVRLKTEA-EDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPD--EQLPMYFPTEH
| |..  |.|| |..  .  |..||.|. .      ..| |   .  |   ..|.|| |.|.  . ||.||| .|.. |  . |    |. . |.|  .
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkae
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 106-182 1.1e-11 39.3 In-house 45-118 (287) alignment 
Range on Protein: 106-182
Range on HMM: 45-118/287.0
QANREKNRNPDFPLYDVTRVRLKteaEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIF
. |..|||  ..  .|  || ||   . ...||||.       ....|.|. || .    |||..  ... .|  . 
sqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlc
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 96-179 1.2e-11 39.0 In-house 21-104 (283) alignment 
Range on Protein: 96-179
Range on HMM: 21-104/283.0
PPEEHKTYAFQANREKNRNPDFPLYDVTRVRLKTEAEdekNYINASITS---CPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIF
|. . .  . . |..|||| .   .|. ||.||.|..   .||||.          ..|.|.|| |...    |||||| ..|  | 
pdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv
subfamily_PTPN13_pd Subfamily PTPN13 195-285 1.7e-11 39.0 In-house 161-250 (273) alignment 
Range on Protein: 195-285
Range on HMM: 161-250/273.0
EHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKvTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGG
| |..| .. |.. .||   |  |.. .|. .  ..  ..  .|  ..| . || || ..|..| ...|. |.. .|. |.. .|| || |
esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqg
subfamily_Ptp69D_pd Subfamily Ptp69D 197-285 1.9e-11 38.6 In-house 179-267 (307) alignment 
Range on Protein: 197-285
Range on HMM: 179-267/307.0
GNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGG
 . | ..  ||  |.  .|  ... .|. |. ..   |  ..  ..|   | .||  |.|.| ... .  ...||| | . .|||||  
edsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 103-200 2e-11 38.4 In-house 28-123 (267) alignment 
Range on Protein: 103-200
Range on HMM: 28-123/267.0
YAFQANREKNRNPDFPLYDVTRVRLKTEAEDeknYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIF-SPDEQLPMYFPTEHGNAR
.  . |.|.||  |   || ||| |.|. |.   |||||   .   ....|| | |.|     |....  |.. ||  .  .  .......| . |.|.
siaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqak
subfamily_PTPRK_pd Subfamily PTPRK 198-283 2.7e-11 37.9 In-house 171-256 (314) alignment 
Range on Protein: 198-283
Range on HMM: 171-256/314.0
NARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQR
. | .  ...  ||. .|  | . .|. .  .. |.. ..|. ..|   |  |.  |||.| ..... |...||. . . .|||..
eirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrk
subfamily_PTPRA_pd Subfamily PTPRA 196-284 3.4e-11 37.6 In-house 187-275 (330) alignment 
Range on Protein: 196-284
Range on HMM: 187-275/330.0
HGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
. ..| .. .|.  ||.  |   |. .|. .  ..  .... |   .| . |. |. .||..| ..| .  .. ||. | . .|| || 
ekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrp
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 85-186 4.4e-11 36.9 In-house 15-121 (347) alignment 
Range on Protein: 85-186
Range on HMM: 15-121/347.0
GFFKSSSFERTPPeEHKTYAFQANREKNRNPDFPLYDVTRVRLKTE------AEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVI
 .| .   . .|. .  .  .. . .|||  |  | | ||| |  |      |.| ..|||||      .....|..|.|. .    |||||.   .  .
tyfdenlanysps.kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqv

FAIFSPDE
 .|| | .
vtifepik
subfamily_PTPRN_pd Subfamily PTPRN 104-193 4.9e-11 36.9 In-house 52-147 (297) alignment 
Range on Protein: 104-193
Range on HMM: 52-147/297.0
AFQANREKNRNPDFPLYDVTRVRLKTEAE-DEKNYINAS-ITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDE----QLPMYFP
  . | .|||. ..  || .||.||.||. ....||||| |.   | .  .| .| |. .    ||.||. | . || .. . .|    |   |.|
kaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 107-179 8.7e-11 36.3 In-house 48-121 (315) alignment 
Range on Protein: 107-179
Range on HMM: 48-121/315.0
ANREKNRNPDFPLYDVTRVRL-KTEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIF
 |..|||  .   || .||.|  .| ... .|.||.       .|..| || |  .  . ||..|| ..|  | 
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkiv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 94-180 1e-10 36.2 In-house 27-112 (307) alignment 
Range on Protein: 94-180
Range on HMM: 27-112/307.0
RTPPEEHKTYAFQANREKNRNPDFPLYDVTRVRLKTEAEdEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFA
.  ||   . ||.|| .|||  | .  | .|. .|..     .|| |         .|.|.|| |...    || |.  .... .  
kktpegvtveafsantdknryqdvkcqdkgrivvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 99-187 1.1e-10 36.1 In-house 39-128 (319) alignment 
Range on Protein: 99-187
Range on HMM: 39-128/319.0
EHKTYAFQANREKNRNPDFPLYDVTRVRLKT-EAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ
. ..   . |..||| ..   || ||| |.. .  .. .|||||       ..|.| .| |...  | ||.||. .|. ..  .    |.
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklvek
subfamily_PTPN6_pd Subfamily PTPN6 194-286 1.2e-10 35.9 In-house 180-279 (306) alignment 
Range on Protein: 194-286
Range on HMM: 180-279/306.0
TEHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTK----GKCLIHSAEGINRSMSFIAVDYIIELMFRN---NTVDIPELITQLRSQRGGA
......| .  .|.  ||   |  .|...|  .  ..   . ..    |  ..| ..|| |  .|| .| ...|. ..     .|| .|. ..|.|| | 
kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsgl
subfamily_PTPN12_pd Subfamily PTPN12 195-284 1.2e-10 35.8 In-house 165-257 (290) alignment 
Range on Protein: 195-284
Range on HMM: 165-257/290.0
EHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNT---VDIPELITQLRSQRG
 ... | .. .|| .||   |  |.| .|. | ...   .  .   ..| . |. |    ||.||. ||. ....   .|. .|...|| || 
aqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqra
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 204-286 1.5e-10 35.6 In-house 165-250 (274) alignment 
Range on Protein: 204-286
Range on HMM: 165-250/274.0
ILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTK---GKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGA
   |..||  ..  ... .|. .   . | . ..   .  ..| . || |   |||..  .  . ....||. .....|| .||| 
hywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGm
0048179 (Phosphotyrosine protein) phosphatases II 196-288 1.6e-10 36.4 In-house 48-129 (144) alignment 
Range on Protein: 196-288
Range on HMM: 48-129/144.0
HgnarfITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKvTKGKCLIHSAEGINRSMSFIAVDyiieLMFRNNtVDIPELITQLRSQRGGALP
.     .. ...  ||  .| .... .|. .  ..   .  .|..|.|   |..|. ...| .    ||.... ... | . ..||.| || |
e.....giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavp
subfamily_PTPN13_pd Subfamily PTPN13 105-182 1.8e-10 35.6 In-house 34-109 (273) alignment 
Range on Protein: 105-182
Range on HMM: 34-109/273.0
FQANREKNRNPDFPLYDVTRVRLKTEAEdeknYINASITSCPPCERK--WIVAQHPMKEYYEYFWKMVFYQEIDVIFAIF
 ..|..|||  .   || |||.|. |.     |||||    |  . .   |..| |. |  . ||.||. |. .||  . 
kkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 99-195 1.9e-10 35.5 In-house 51-147 (319) alignment 
Range on Protein: 99-195
Range on HMM: 51-147/319.0
EHKTYA-FQANREKNRNPDFPLYDVTRVRLK-TEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFspDEQLPMYFPTE
  .|.|  . |..|||  .   .| ..|.|. .. |.  .|||||  .    . |.| || |...  . ||.|.. ...  |  .    ..   |.| .
adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplk
subfamily_PTPRB_pd Subfamily PTPRB 197-283 1.9e-10 35.2 In-house 176-264 (293) alignment 
Range on Protein: 197-283
Range on HMM: 176-264/293.0
GNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSD--KVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQR
 . | .. .|.  ||   |  ..| .|. .. .. .   . .|.  ..| . |. |.  |||.| ... . ....|||  ....||..|
keerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeR
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 100-195 2e-10 35.6 In-house 16-111 (284) alignment 
Range on Protein: 100-195
Range on HMM: 16-111/284.0
HKTYA-FQANREKNRNPDFPLYDVTRVRLKT-EAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFspDEQLPMYFPTE
 .|.|  . |..|||  .   .| ..|.|.    |.  .|||||  .    . |.| .| |...  . ||.|.. ...  |  .   ...   |.| .
dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplk
0048076 (Phosphotyrosine protein) phosphatases II 193-289 2.6e-10 35.7 In-house 38-128 (145) alignment 
Range on Protein: 193-289
Range on HMM: 38-128/145.0
PTEHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKvTKGKCLIHSAEGINRSMSFIAVDyiieLMFRNNtVDIPELITQLRSQRGGALPR
.....  |... ..|  ||  .| .... .|. .  ..   |  .|..|.|   |..|. ...| .    ||.... |...| . ..|||| || |.
selellerlgiqylylpwpDhgvpdllellleflefieealk.eggpvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqrpgavpn
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 96-178 2.7e-10 34.4 In-house 24-109 (281) alignment 
Range on Protein: 96-178
Range on HMM: 24-109/281.0
PPEEHK-TYAFQANREKNRNPDFPLYDVTRVRLKT--EAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVI
|| .   ..    | .|||  . |  |..||.||     ..  .|| |     |  .| .|..| | ||    ||.|.. ..   |
ppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 104-181 3.8e-10 34.4 In-house 46-123 (297) alignment 
Range on Protein: 104-181
Range on HMM: 46-123/297.0
AFQ-ANREKNRNPDFPLYDVTRVRLKTEAED-EKNYINASITscPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAI
| .  | ||.|  .   ||. ||.|.   .| . .|.|||    .  . ..|  | |||.  . ||.||. ... .|  .
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivml
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 198-286 4.3e-10 34.3 In-house 183-272 (298) alignment 
Range on Protein: 198-286
Range on HMM: 183-272/298.0
NARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTK-GKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGA
. | .  ||. .||   |.   . .|  .   . | . ..    ... ..|..|| .|||.| ..| . ....||. . .  || .| ||
kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpga
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 105-183 4.8e-10 33.8 In-house 43-124 (290) alignment 
Range on Protein: 105-183
Range on HMM: 43-124/290.0
FQANREKNRNPDFPLYDVTRVRLK--TEAED-EKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFS
 . |...||  .. .||  |. |.  .. .| ...||||.       ....|..| |...    |||..  ... .|  . .
tssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltn
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 101-197 6.1e-10 33.6 In-house 21-124 (274) alignment 
Range on Protein: 101-197
Range on HMM: 21-124/274.0
KTYAFQANREKNRNPDFPLYDVTRVRLKTEAEDE--KNYINASITSCPPCERK-WIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQLP----MYFP
. .    . .|||  .    . .|| |..|  ..   .||||     .  | | .. .| |. .  . ||.|....|..||  .    |.      .|||
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

TEHG
....
daed
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 106-181 6.3e-10 33.4 In-house 31-107 (297) alignment 
Range on Protein: 106-181
Range on HMM: 31-107/297.0
QANREKNRNPDFPLYDVTRVRLKTeAEDEKNYINASITSCPP--CERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAI
..   |||  |   .| |||.|.  .  |..||||     |    . |.|.|| |...  . ||..|. |.. ||  .
nsslrknryrdilatddtrvkllr.viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 104-179 6.5e-10 33.3 In-house 40-116 (315) alignment 
Range on Protein: 104-179
Range on HMM: 40-116/315.0
AFQANREKNRNPDFPLYDVTRVRL-KTEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIF
  . | .|||  .   .| .||.|   . . ...|||||      ... .| .| | |   . ||.||. ...  | 
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttiv
subfamily_PTPRA_pd Subfamily PTPRA 106-178 7.7e-10 33.2 In-house 56-129 (330) alignment 
Range on Protein: 106-178
Range on HMM: 56-129/330.0
QANREKNRNPDFPLYDVTRVRLKT-EAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVI
. |.|||| ..   || .|| | . | ..| .|||||         |.| || | .|  | ||.|.. |.   |
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksati
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 195-287 1e-09 33.0 In-house 173-266 (305) alignment 
Range on Protein: 195-287
Range on HMM: 173-266/305.0
EHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKG-KCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGAL
|  . | .. ..   ||   |  ..  .|. |  .| . |  ||   |.|  .|. |.  |||||  .| . . ..||. |.. ||||.| ...
edkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 195-283 1.4e-09 32.4 In-house 170-259 (318) alignment 
Range on Protein: 195-283
Range on HMM: 170-259/318.0
EHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSD-KVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQR
|. . | .   ||  ||   |  |.  .|  . . .  . | ..|  ..| . |. |   ||||| ..| .  ...||. . ..|||.||
eeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqr
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 198-285 1.5e-09 32.4 In-house 135-223 (250) alignment 
Range on Protein: 198-285
Range on HMM: 135-223/250.0
NARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKV-TKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGG
. | .  ||.  ||   |    . .|  .  .| |..   ..  ... ..|. || .|||.| ..| . ....||. ..| .|| .| .
derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrph
subfamily_PTPN6_pd Subfamily PTPN6 105-181 2e-09 31.9 In-house 51-129 (306) alignment 
Range on Protein: 105-181
Range on HMM: 51-129/306.0
FQANREKNRNPDFPLYDVTRVRLKTEAEDEKNYINASITS--CPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAI
 . |.||||      .| ||| || .   ...||||.. .   .  ....| .|  ...  . ||.||. ..  ||  .
kpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmt
subfamily_PTPN3_pd Subfamily PTPN3 196-284 2e-09 31.8 In-house 167-255 (280) alignment 
Range on Protein: 196-284
Range on HMM: 167-255/280.0
HGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
  . | |. | |  ||   |  ... .|. . ...   ....   ..| . ||.|.  .|...  . |. ... | ..... ..| ||.
tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqra
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 100-182 2.1e-09 31.5 In-house 40-120 (305) alignment 
Range on Protein: 100-182
Range on HMM: 40-120/305.0
HKTYAFQANREKNRNPDFPLYDVTRVRLktEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIF
 |..    ...|||  |    |  ||.|  |.   ..|| |   | |   ...| .| |...    || | . . .. || . 
mkafkeaqeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlc
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 104-187 2.1e-09 31.4 In-house 91-174 (244) alignment 
Range on Protein: 104-187
Range on HMM: 91-174/244.0
AF-QANREKNRNPDFPLYDVTRVRLKTEAeDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ
||   |  |||.     .|. || |   .   . |||||.  |     ..|..|||. .    ||||.. . ..|.  . | .|.
afnpnnswknregaglpfdfnrvplskgs.mgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 198-284 2.1e-09 31.9 In-house 176-263 (319) alignment 
Range on Protein: 198-284
Range on HMM: 176-263/319.0
NARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKV-TKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
..| ..  .| .||   |  . . .|  .  .. | .  ..|   .| ..|. |  .||..| ..| . .....|. . . .|| || 
etRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRn
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 106-181 3.8e-09 30.8 In-house 36-111 (287) alignment 
Range on Protein: 106-181
Range on HMM: 36-111/287.0
QANREKNRNPDFPLYDVTRVRLKTEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAI
 |. .|||  |   .| ||| | .|.|   .||||   .    . ..|.|| |.      ||..|. ..  ..  .
laavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 107-179 4.4e-09 30.0 In-house 42-115 (515) alignment 
Range on Protein: 107-179
Range on HMM: 42-115/515.0
ANREKNRNPDFPLYDVTRVRL-KTEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIF
 | .|||  .   || .||.|   . . ...|.|||      ... .| .| | |   . ||..|. ...  | 
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttia
subfamily_PTPN1_pd Subfamily PTPN1 197-285 5e-09 30.3 In-house 159-252 (290) alignment 
Range on Protein: 197-285
Range on HMM: 159-252/290.0
GNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVT--KGKCLIHSAEGINRSMSFIAVDYIIELMFRNN---TVDIPELITQLRSQRGG
 ..| |.  ||  ||   |  ||   |. .. .. |  ..  .|  .|| . || || .|. || .. |. ...   .||| . . .||..| |
qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlG
0051082 (Phosphotyrosine protein) phosphatases II 152-286 6.2e-09 31.1 In-house 15-135 (151) alignment 
Range on Protein: 152-286
Range on HMM: 15-135/151.0
WIVAQHPMKeyyeYFWKMVFYQEIDVIFAIFSPDEQLpmY----FPTEHgnaRFITILHYPHWPKGHVAPSPKVILRGIYSLQPsdkVTKGKCLIHSAEG
 .. ..|.      |....  . |..|. . |..|    |    .| .    . .. .... ||   .  |.. .|. .  |.      .|..|.|   |
lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaG

INRSMSFIAVDYIIeLMfrnntVDIPELITQLRSQRGGA
..|.  ..|.. .. |.     |.. | . ..|..|.|.
kgRTGtlvalylml.lg.....vsleealeeyrlkrpgv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 196-284 6.6e-09 30.1 In-house 148-244 (270) alignment 
Range on Protein: 196-284
Range on HMM: 148-244/270.0
HGNARFITILHYPHWPKGHVAPSPK------VILRGIYSLQPSDK-VTKG-KCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
.|. | ..  .| .||   | ...        .|. .  .. | |   |.  .|.| ..|..|.  .||.|....|. ... ||. ..|..|| .| 
kgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRm
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 107-179 1.3e-08 29.3 In-house 2-74 (237) alignment 
Range on Protein: 107-179
Range on HMM: 2-74/237.0
ANREKNRNPDFPLYDVTRVRLKTEAEDeKNYINAS-ITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIF
 |. |||  .   || .|| ||    .  .||||. . .     .|.| || |..   . ||.||. .   || 
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsviv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 192-286 1.4e-08 28.5 In-house 173-267 (302) alignment 
Range on Protein: 192-286
Range on HMM: 173-267/302.0
FPTEHGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGA
.| .  |. .... .   |.. .|  .   . . . ..  ..  .. ...| | .|. |  .|...   .| . ... . | |.....||||  |
lPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpra
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 104-179 1.8e-08 28.5 In-house 36-114 (301) alignment 
Range on Protein: 104-179
Range on HMM: 36-114/301.0
AFQANREKNRNPDFPLYDVTRVRLKTEAE---DEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIF
  ..|.. ||. .   ||  |. ||.. .    ...|||||  .    ..|.|.|| |||.    ||.... .    | 
lseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv
subfamily_PTPRN_pd Subfamily PTPRN 197-285 2.1e-08 28.2 In-house 184-273 (297) alignment 
Range on Protein: 197-285
Range on HMM: 184-273/297.0
GNARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRN-NTVDIPELITQLRSQRGG
 ..| .| .|.  ||.  | .|.| .|     .. | .      ..|. .|  |.  .|..| ... . .  . .||   .  || || |
setrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpg
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 195-283 3.7e-08 27.8 In-house 165-255 (281) alignment 
Range on Protein: 195-283
Range on HMM: 165-255/281.0
EHGNARFITILHYPHWPKGHVAPSPKVILRGIYSL-QPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRN-NTVDIPELITQLRSQR
|.|..| .. |.|  ||   |  ..| .|     . . ..| ||   .|| . |. |. ..||.| ... . .. ...|. .....|| .|
esgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrker
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 95-199 4e-08 27.8 In-house 32-143 (325) alignment 
Range on Protein: 95-199
Range on HMM: 32-143/325.0
TPPEEH---KTYAFQANREKNRNPDFPLYDVTRVRLKTEAEDE-KNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFS---PDEQ
.|...    |. .  .|..||| ..   .| .|| |.|  .|   .|||||          .. || |. .  . .|..|.  .  |.  .      ...
lpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdr

LPMYFPTEHGNA
  .|.| | |..
cavywpkemgks
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 107-180 5.1e-08 26.9 In-house 54-126 (305) alignment 
Range on Protein: 107-180
Range on HMM: 54-126/305.0
ANREKNRNPDFPLYDVTRVRLKTEAedEKNYINASITSCPPC-ERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFA
 .  |||  | |  | . |.|.  .    .|| |    ||   |...|.|| |. .  . || ||  . .. |  
iaitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivm
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 198-284 5.3e-08 27.7 In-house 147-235 (284) alignment 
Range on Protein: 198-284
Range on HMM: 147-235/284.0
NARFITILHYPHWPKGHVAPSPKVILRGIYSLQP--SDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
. | |.  |.  ||.  |  .|  ..| .  ..   | .  . . ..| . |. |.  .|..| ... | ... ||. ... .|| || 
dirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrn
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 198-284 5.9e-08 27.4 In-house 183-271 (319) alignment 
Range on Protein: 198-284
Range on HMM: 183-271/319.0
NARFITILHYPHWPKGHVAPSPKVILRGIYSLQP--SDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
. | ||  |.  ||.  |  .|  ..| .  ..   | .  . . ..| . |. |.  .|..| ... | ... ||. ... .|| || 
dirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrn
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 104-179 6.3e-08 26.5 In-house 48-123 (310) alignment 
Range on Protein: 104-179
Range on HMM: 48-123/310.0
AFQANREKNRNPDFPLYDVTRVRLKTEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIF
|.. .  |||  |    | .||.|| .    ..|| |           .|..| |..     ||.|.| .  . |.
aykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil
subfamily_CG7180_pd Subfamily CG7180 197-284 7.2e-08 26.4 In-house 177-270 (296) alignment 
Range on Protein: 197-284
Range on HMM: 177-270/296.0
GNARFITILHYPHWPKGHVAPSP-K----VILRG-IYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
 . | .. ...  |. ..  |.  .    .. |  ..  .  .. ..|  ...| .|  ||  ..|.|  .||. ... ||. | . .|| .| 
aetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRp
subfamily_eak_pd Subfamily eak 120-181 9e-08 25.9 In-house 63-124 (332) alignment 
Range on Protein: 120-181
Range on HMM: 63-124/332.0
YDVTRVRLKTEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAI
||   ||| .   ... |||||..  .   ||.|..  . ..   .||.||. |    |  .
ydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivql
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 102-180 1e-07 26.2 In-house 29-105 (285) alignment 
Range on Protein: 102-180
Range on HMM: 29-105/285.0
TYAFQANREKNRNPDFPLYDVTRVRLKTEaedEKNYINASITSCPPCER-KWIVAQHPMKEYYEYFWKMVFYQEIDVIFA
  |..|| . ||  |    . ||| ||     ...|| ||    |  ..  .| .| |. |    ||.|.. ..|  .. 
ytayeanpdlnryadvrcieetrvvlknh...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlm
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 198-283 1.1e-07 26.0 In-house 171-256 (315) alignment 
Range on Protein: 198-283
Range on HMM: 171-256/315.0
NARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQR
. | .|  ..  ||.  |      .|. |  .. ...  .   |.| . |. |.  .|..| ... . |...||. .....||..|
esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakr
subfamily_PTPN14_pd Subfamily PTPN14 197-284 1.3e-07 25.9 In-house 180-276 (300) alignment 
Range on Protein: 197-284
Range on HMM: 180-276/300.0
GNARFITILHYPHWPKGHVAPSPKVIL---RGIYSLQPSD------KVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
.. | . .| |  ||. .| . .|  |   . . |..         | .|   |.| ..|. |.   | .| .|. .  |...||.. ...|| || 
keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrm
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 199-284 1.6e-07 25.1 In-house 173-259 (439) alignment 
Range on Protein: 199-284
Range on HMM: 173-259/439.0
ARFITILHYPHWPKGHVAPSPKVILRGIYSLQ-PSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
 | .  .||  ||.  |      .|  . ...   ||   |  ..| . |. |. . ||.|  .| .  .| |||  ... || || 
ertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrk
subfamily_PTPRG_pd Subfamily PTPRG 200-284 1.7e-07 24.9 In-house 183-267 (563) alignment 
Range on Protein: 200-284
Range on HMM: 183-267/563.0
RFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
. ..  ||..||   |  ..   |  .   . . | . |  ..|  .|. |.  .|..| ... . ..|.|.. ... ..|.|| 
klvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRn
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 201-287 2.2e-07 24.6 In-house 189-271 (302) alignment 
Range on Protein: 201-287
Range on HMM: 189-271/302.0
FITILHYPHWPKgHVAPSPKVILRGIYSLQPSdkvTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGAL
 . ||..  ||. | ||        |     |    | . |.| ..|. |. ...|. | |.|  .... |. .... .|. | ||.
tvdilafsawpd.hGapkeaytaldilkfces...ykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGav
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 102-178 4.2e-07 24.2 In-house 14-92 (270) alignment 
Range on Protein: 102-178
Range on HMM: 14-92/270.0
TYAFQANREKNRNPDFPLYDVTRVRLKTEAEDE-KNYINASITS-CPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVI
  ..  ... ||  |     .|||||... ||.  .||||         ..|.| |. |..   . ||.|.. ..   |
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtai
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 199-284 4.8e-07 23.8 In-house 180-261 (301) alignment 
Range on Protein: 199-284
Range on HMM: 180-261/301.0
ARFITILHYPHWPKGHVaPSPKVilrGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
.| .|   | .|..  | |  ..    .. |    | ..   ..| ..|| ||..||. .|.   .  ..|... | . .|| .| 
trtvthyqysewtdrgv.Pksha...elfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrw
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 197-286 5.1e-07 23.8 In-house 175-265 (290) alignment 
Range on Protein: 197-286
Range on HMM: 175-265/290.0
GNARFITILHYPHWPKGHVAPSPKVILRGIYSLQP-SDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGA
|... .| ..   |..    . |. ||  |.  .    | ...  ..|  ... ||  |.|..  |. .  .  .|. ... ..|.|. | 
gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgs
subfamily_PTPN23_pd Subfamily PTPN23 199-283 5.1e-07 23.8 In-house 170-259 (288) alignment 
Range on Protein: 199-283
Range on HMM: 170-259/288.0
ARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKC----LIHSAEGINRSMSFIA-VDYIIELMFRNNTVDIPELITQLRSQR
 . .. |..  ||.  |  ||...|. .   . . . .. |.    ..|   |..|.  |   .  ..||  .|  .||.... .|| ||
vksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqR
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 104-183 8.5e-07 22.8 In-house 44-124 (439) alignment 
Range on Protein: 104-183
Range on HMM: 44-124/439.0
AFQANREKNRNPDFPLYDVTRVRL-KTEAEDEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFS
| . .. |||  |   .| ||| | ..       ||||        .. .| .| | ||  . ||..|. .    |  .  
aqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltn
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 198-283 8.5e-07 22.4 In-house 170-255 (515) alignment 
Range on Protein: 198-283
Range on HMM: 170-255/515.0
NARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQR
..| .|  |.  ||.  | .  . .|. |  .. .    .   .|| . |. |   .|..| ..  .   ..||. ...|..| .|
dsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 202-284 8.9e-07 22.8 In-house 190-269 (305) alignment 
Range on Protein: 202-284
Range on HMM: 190-269/305.0
ITILHYPHWPKGHVAPSPKVILRGIYSLQPSdkvtKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTV-DIPELITQLRSQRG
.  |.. .||   | |     |  . ... |    |   ..| . || |. . .|..||.| .  |. .  .|||.  || || 
vrhlqwtewpdrgvppckltslellsairgs....kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqra
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 101-181 1.5e-06 22.1 In-house 44-121 (301) alignment 
Range on Protein: 101-181
Range on HMM: 44-121/301.0
KTYAFQaNREKNRNPDFPLYDVTRVRLKTEAedEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAI
..||.  ...|.| |  |    | |.. ..   ..  | |   . .   ...|..| |.|.  | || |. . ... |  .
esyayl.pkdkhryptvPckPstavevivdG..krvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivml
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 197-284 1.7e-06 22.3 In-house 173-257 (307) alignment 
Range on Protein: 197-284
Range on HMM: 173-257/307.0
GNARFITILHYPHWPKGHVapsPKVILRGIYSLQPSdKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFR-NNTVDIPELITQLRSQRG
...| |. | .  ||   |   |.. |  |  |.   .  .   ..| . |. || . .|. .. . |..  |  |. .|. .||||| 
qksrtiqhlqwenwpdrgv...pqinltainlleav.rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrh
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 198-286 1.7e-06 22.2 In-house 173-261 (315) alignment 
Range on Protein: 198-286
Range on HMM: 173-261/315.0
NARFITILHYPHWPKGHVAPSPKVILRGIYSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGA
| | .  |||  ||.  |. .   ..  |   .  .. . |  ..|  .|. |. .||..| ... .  .| .|. ..||..|..| ..
nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikm
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 198-284 2e-06 21.8 In-house 184-267 (305) alignment 
Range on Protein: 198-284
Range on HMM: 184-267/305.0
NARFITILHYPHWPKGHVAPSPKVILRgiysLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPE-LITQLRSQRG
.|| .|  |.  ||   | ..   ||     |    ...||   .| . || |. | . ..||.. ..  . ..  . .. ..| || 
karkvthyhwidwpdrgvpaadlaile....llekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrn
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 120-187 2.2e-06 22.0 In-house 5-65 (130) alignment 
Range on Protein: 120-187
Range on HMM: 5-65/130.0
YDVTRVRlkteaedEKNYINASITSCPPCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFAIFSPDEQ
..|.|..       ...|||||   .    .... .|||. .    ||||.. . ..|.  . | .|.
fevsrlq.......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 199-284 2.5e-06 21.1 In-house 88-174 (440) alignment 
Range on Protein: 199-284
Range on HMM: 88-174/440.0
ARFITILHYPHWPKGHVAPSPKVILRGIYSLQPS-DKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRG
.| .   ||  ||   |      .|. |  .. | .|. .|  |.|.. |  |.   |||| |.    |.. .||  .|  .|..| 
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrp
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 202-285 2.8e-06 21.6 In-house 158-240 (267) alignment 
Range on Protein: 202-285
Range on HMM: 158-240/267.0
ITILHYPHWpkgHVAPSPKVILRGIYSLQPSDKVTKGK--CLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGG
.|. .| .|    .    |  |. .. .   ... .|    ... ..|. || .|. .|  .| . .....|| ... ..|||| |
vtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqrig
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 202-287 2.8e-06 21.3 In-house 190-276 (301) alignment 
Range on Protein: 202-287
Range on HMM: 190-276/301.0
ITILHYPHWPKGHVAPSPKVILRGIYS-LQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGAL
.. |.   ||.  | . |. .|. |   ..   |. .|. ..|  ... ||  ...|.  .|   ..  ||. ...  .| .. || 
vlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaV
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 226-287 2.8e-06 21.5 In-house 190-249 (283) alignment 
Range on Protein: 226-287
Range on HMM: 190-249/283.0
IYSLQpsDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGGAL
. |||   .  ||  ..| ..|| |.  |||.   .. .  .  ||... .. .| || .|.
vislq..teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmav
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 199-283 3.8e-06 21.2 In-house 176-263 (297) alignment 
Range on Protein: 199-283
Range on HMM: 176-263/297.0
ARFITILHYPHWPKGHVAP--SPKVILRGIYSLQPS-DKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQR
 |..   .. .||.  |    | . .|  |  .. . .....|  |.|   |. |   ....| ..  . |...||| .|...|| .|
rrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqer
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 103-180 4.2e-06 20.6 In-house 49-124 (290) alignment 
Range on Protein: 103-180
Range on HMM: 49-124/290.0
YAFQANR--EKNRNPDFPLYDVTRVRLKTEAedEKNYINASITSCppCERKWIVAQHPMKEYYEYFWKMVFYQEIDVIFA
  |..|   .|||  | .  |.||| ||     . .|. |        .  .|..| ..|.    .|.||  ... .|  
kifdkntefkknrykdvvcndktrvilkdGy..dGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivm
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 197-285 4.2e-06 21.0 In-house 170-259 (287) alignment 
Range on Protein: 197-285
Range on HMM: 170-259/287.0
GNARFITILHYPHWPKGHVAPSPKVILRGIYS-LQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGG
|. . ..  ..  |..    ..|. ||  |    .   | ...  ..| .... ||  |.|..  |.   .. ..|. ... . | |. |
gdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpg
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 104-185 4.8e-06 20.3 In-house 30-111 (332) alignment 
Range on Protein: 104-185
Range on HMM: 30-111/332.0
AFQANREKNRNPDFPLYDVTRVRLKTEaEDEKNYINASITSCPPCERKWIVAQHPMKEYYEY-FWKMVFYQEIDVIFAIFSPD
 |  | . || | .  .| .|| |  . . . .. |||       .  .|.|| |.... || ||.||  ..  .|. .   |
kflnnmdmnriphlycfdhsrvelapq.dgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdid
subfamily_CG42327_pd Subfamily CG42327 227-287 5.3e-06 20.3 In-house 237-298 (319) alignment 
Range on Protein: 227-287
Range on HMM: 237-298/319.0
YSLQPSDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRN-NTVDIPELITQLRSQRGGAL
 | . . .  .|   .| ..|. |.   || |  |. .  . ..||||.|. ..| .|. |.
issrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 196-285 5.7e-06 20.2 In-house 179-264 (290) alignment 
Range on Protein: 196-285
Range on HMM: 179-264/290.0
HGNARFITILHYPHWPKGHVAPSPKVILRGIYSLQpsdkVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQRGG
 |    .  |.   ||   || |   .|| ...|.     . |   .| . || |. .|.|..  ....     .|. .|.  ||  | .
sGkehklkhlkikswpdksvalstlallrtlrilr....kasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrln
subfamily_PTPN9_pd Subfamily PTPN9 240-283 7.8e-06 20.1 In-house 226-269 (297) alignment 
Range on Protein: 240-283
Range on HMM: 226-269/297.0
CLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQR
 ..| . || |.  ||..|. .. . . .|||. | . .||.||
ivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 202-283 9.9e-06 19.3 In-house 192-269 (310) alignment 
Range on Protein: 202-283
Range on HMM: 192-269/310.0
ITILHYPHWPKGHVaPSPKVILRGIYSLqpsDKVTKGKCLIHSAEGINRSMSFIAVDYIIELMFRNNTVDIPELITQLRSQR
......| ||   | |  |.       |    .| .| |..| . |..|    .|... |. . | . ||. |..|.|. .|
vslikwpnwpdrgv.pdekchtvpqrll...aqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksr