Gene Y62F5A.10 in Caenorhabditis elegans

Synonym: CELE_Y62F5A.10, Y62F5A.10

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP225_AA protein Get Run
CeleP225_AA_132-405 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 126-419 2.4e-124 408.7 In-house 4-300 (302) alignment
Range on Protein: 126-419
Range on HMM: 4-300/302.0
SEAPVKWKAEDVAVAYIGKLDASQTRPEYiDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGL
.|.. ||..|..|.... .||......|. . . ..|...|.|...||||.|||.. .||||..||| .|.||||||.|.| ||.....|...|.||.. 
eeekekWveeeeakklvksldtaevkkef.kkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvds

E---EEFWRAAYNEQVVMMYVLVGSEDEKY---DFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYAN
|   |||||....|..|....|||.|. |.   ..|||..|....||.||||.|||||..||..||.|||||.|.||||..||||.| |..  ||..||.
edsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyae

TTRSVVDVmnFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVPEGLQQKVE
.......|  |.|.....|....|||||.||||.|.|| .|...|....||.| ||||.||||||.||.|.|||.|||..||.|||||.| ||. ..|.|
liktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkkkee





0036941 (Phosphotyrosine protein) phosphatases II 136-418 2.2e-53 176.9 In-house 1-291 (297) alignment
Range on Protein: 136-418
Range on HMM: 1-291/297.0
DVAVAYIGKLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYN
|... ....|. .. . |. ...   .    ... ...|| ||.   ....| | || .  ...|.|.| | ...... ... | |. .  |.|||  ..
dllkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

EQVVMMYVLVGSEDE----KYDFFPKTTGSFLYYGEMFVNVRKVEKM-DEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNF
..| .  .|.  ..      . ..| ..|..|.||...|....||.. ...  ..|.||...| ..| ..... .|||  .|||  .|   . .  | ..
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

VKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLN---DNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVPEGLQQKV
 | ...... || ...|.||.| ||..  ....|.    . .. | |.|| .|.|||.||..  ||  || .||...||| |... |....
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl

0040438 (Phosphotyrosine protein) phosphatases II 132-422 8.2e-51 168.5 In-house 2-294 (317) alignment
Range on Protein: 132-422
Range on HMM: 2-294/317.0
WKAEDVAVAYIGKLDASQTRPEYIDVCVATKAnIENCTVWKKNLAKNQTDVYPILDATLVK----DPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEE
.. .. |. .. |.|. . . |..|..  ..    ... ...|  ||.   ....|.. ||    ..  ...|.|.| | .|...  ... | |. .  |
vldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntve

EFWRAAYNEQVVMMYVLVGSEDEK----YDFFPKttGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIryanTTRS
 |||  ....| .   |. .|. .    . ..|   |..|.||...|.....|. ...   .|.|| ..| |.|...... .|||  .|||     ....
dFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvpp....spdl

VVDVMNFVKSS--NGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVPEGLQQKVEDL
..| ...|...  ......|| ...|.||.|.||..  ....|. . .. . |.|| .|.|||.||..  ||  || .||.|.|.|.| ..  ..|.. |
lldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkll

K
|
k

0050432 (Phosphotyrosine protein) phosphatases II 123-410 3.1e-50 166.6 In-house 17-305 (308) alignment
Range on Protein: 123-410
Range on HMM: 17-305/308.0
PALSEAPVKWKAEDVAVAYIGKLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVKDpAKPDSYVNMSSVIVP--HCSYPILMGQI
. ..    |.  .|.. .. ..|| .. . |. ...  .  .  ... ...|  ||.   ....| . ||   ....|.| | | ..  ...  ... | 
tsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqg

PKRGLEEEFWRAAYNEQVVMMYVLVGSEDEK----YDFFPKTTG-SFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPI
|. .  | |||  ....| .  .|   .. .    . ..| ..| ..|.|| ..|.....|. ...  ..|.|. ..| ..| ..... .|.|. .||| 
PlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPp

RyantTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITV
     .....| ...|..|..... .| ...|.||.| ||.|  ....|. . .. . |.|| .|.|||..|..  ||  || .||.|.|.|.| 
s....peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk

0039614 (Phosphotyrosine protein) phosphatases II 122-410 7.5e-48 158.9 In-house 6-295 (297) alignment
Range on Protein: 122-410
Range on HMM: 6-295/297.0
TPALSEAPVKWKAEDVAVAYIGKLDASQTRPEYIDVCVATKaNiENCTVWKKNLAKNQTDVYPILDATLVKDPAKPD-----SYVNMSSVIVPHC-SYPI
 ..|.  |......|... .. ... .. . |. ...  .  .   .. ...|  ||.   ....| . ||   ...     .|.|.| | .... .  .
dallesipiplsvldlllllekansktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

LMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE---KYDFFPKTTGsflYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSnsVMMNVYVHTGWEPFG
.. | |  .  | |||  ....| .   |   ..     ....| ..|   .||...|...|||. ..   ..|.|| .|| |   ..... .|||  .|
IatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtnnges..rtvthfqytgwpdhg

VPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITV
||   .   . .  |............ || ...|.||.| ||..  ....|. . .. . |.|| .|.|||.||..  ||  || .||...|.| |.
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkltl

0047943 (Phosphotyrosine protein) phosphatases II 144-405 1.6e-47 157.7 In-house 8-273 (273) alignment
Range on Protein: 144-405
Range on HMM: 8-273/273.0
KLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYV
.|. .. . |. ...  ..    .......|. ||.   ....| . || . ....|.| | | .....  ... | |. .  |.|||  ....| .  .
llgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

LVGSEDE----KYDFFPKTTGS-FLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSE
|.  ..      . ..| . |. .|.||...|.....|. ..    .|.|. ..|...| ..... .|||  .|||  ..   . . .|... .......
LtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

KLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
. .| ...|.||.| ||.|  ....|. . .. . |.|| .|||||..|..  ||  || .||.|.|
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleylk

0043336 (Phosphotyrosine protein) phosphatases II 130-405 1.6e-45 151.1 In-house 2-278 (278) alignment
Range on Protein: 130-405
Range on HMM: 2-278/278.0
VKWKAEDVAVAYIGKLDASQTRPEYIDVCVATKaNIENCTVWKKNLAKNQTDVYPILDATLVKDPAKP----DSYVNMSSVIVPHCSYPILMGQIPKRGL
...|    |...... . . .. |. ...  .. .  ... ...|  ||..  ....| ..||    .    ..|.| | | .....  ... | |  . 
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

EEEFWRAAYNEQVVMMYVLVGSEDEK----YDFFPkttGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTT
.| |||  ....| .  .|.. .. .    . ..|   |..|.||...|...|.|. ..   ..|.|| ..| ..| . ..| ..||  .|||   .   
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

RSVVDVMNFVKssNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
. . .|.....  . ....|| ...|.||.| ||.|  ....|... .. . |.|| .|.|||.||..  ||  || .||.|.|
dflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleylk

0046845 (Phosphotyrosine protein) phosphatases II 167-411 8.4e-44 145.4 In-house 21-281 (284) alignment
Range on Protein: 167-411
Range on HMM: 21-281/284.0
NCTVWKKNLAKNQTDVYPILDATLVKDPAKP-----DSYVNMSSVIVP-----HCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KY
.......|| ||.   ....| . ||    .     ..|.| | | ..     ...  ... | |. .  |.|||  ....| .  .| . ..      .
svallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekca

DFFPKTtGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNG-FSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRA
 ..| . |..|.||...|.....|. ..   ..|.|. ..|  ..|...... .|.|  .|||   ..  . . .| .. ....|... .| ...|.||.
qYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRt

GFFITLGAAFCCLNDNS---EPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVP
| ||.|  ....|. ..   .. . |.|| .|.|||..|..  ||  .| .||.|.|.|.|..
GtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll

DSPc_SM00195 167-405 8.9e-42 138.6 In-house 19-263 (263) alignment
Range on Protein: 167-405
Range on HMM: 19-263/263.0
NCTVWKKNLAKNQTDVYPILDATLVKDPA----KPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKT
... .||| .||.   ... | | || .     ....|.| . . .....  . . | |.    |.|||  ..|.| . ..|.  |..     ....|..
teaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

TGSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNG--SEKLLVVSKNGCGRAGFFIT
 |.   .|.. |....|||...|  ..|.|.  .| ...  ...| ...|.  |||    ..|.||......||.|.   |. ..|....|.||.| |.|
sggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp....dstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

LGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
.  .   |...... | ||||..|.|||..|.. .||. .| ..|.|||
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik

PTPc_SM00194 167-405 8.9e-42 138.6 In-house 19-263 (263) alignment
Range on Protein: 167-405
Range on HMM: 19-263/263.0
NCTVWKKNLAKNQTDVYPILDATLVKDPA----KPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKT
... .||| .||.   ... | | || .     ....|.| . . .....  . . | |.    |.|||  ..|.| . ..|.  |..     ....|..
teaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpee

TGSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNG--SEKLLVVSKNGCGRAGFFIT
 |.   .|.. |....|||...|  ..|.|.  .| ...  ...| ...|.  |||    ..|.||......||.|.   |. ..|....|.||.| |.|
sggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvp....dstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

LGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
.  .   |...... | ||||..|.|||..|.. .||. .| ..|.|||
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik

0045450 (Phosphotyrosine protein) phosphatases II 165-407 7.4e-41 136.2 In-house 46-307 (307) alignment
Range on Protein: 165-407
Range on HMM: 46-307/307.0
IENCTVWKKNLAKNQTDVYPILDATLVKDPA-----KPDSYVNMSSV--------IVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDEK
  ... ...|  ||.   ....| | ||        ....|.|.| |         .....  ... | |. .  |.|||  ....| .   | .... .
eysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelg

Y----DFFPKTtGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPN-GFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKN
      ..| . |..|.||...|.....|. ...  ..|.|| .. | ..| . ... .|||  .|||   . . . .  |............ || .. 
rekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsa

GCGRAGFFITLGAAFCCLNDNSE---PRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
|.||.| ||..  . ..|... .   . . |.|| .|.|||.||..  ||  || .||....||
GvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllkk

0040439 (Phosphotyrosine protein) phosphatases II 167-406 1.8e-40 134.5 In-house 4-248 (249) alignment
Range on Protein: 167-406
Range on HMM: 4-248/249.0
NCTVWKKNLAKNQTDVYPILDATLVKDPA----KPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKt
... ...|. ||.   ....| . ||        ...|.|.| . .....  ... | |  .  | |||  ..... .   |   .       . ..|  
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

tGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLG
 |..|.||...|....||.  ..  ..|.|. ......|.. ... .|.|  .|||   . . . .  |...... . ....|| ...|.||.|.||.. 
.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

AAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
 ....|. . .  . |.|| .|||||.||..  ||  || .||....|
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk

0051299 (Phosphotyrosine protein) phosphatases II 144-405 2.9e-40 133.9 In-house 19-287 (288) alignment
Range on Protein: 144-405
Range on HMM: 19-287/288.0
KLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVK----DPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVV
. . .. . |. ...  .  .  .......|| ||.   .. .| . ||    |.  ...|.| | . .....   .. | |. .  |.|||  ....| 
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

MMYVLVGSEDE----KYDFFPKttGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPN----GFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFV
.  .| . ..      . ..|   |..|.||...|. ...|. ...   .|.|| ..    | ..| . ... .|.|  .|||       . . .|... 
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

KssNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
.  .|.   .| ...|.||.| ||.|  ....|. . .. . |.|| .|.|||..|..  ||  .| .||.|.|
a..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk

Y_phosphatase Protein-tyrosine phosphatase 174-401 2.5e-39 130.5 Pfam-A 1-234 (235) alignment
Range on Protein: 174-401
Range on HMM: 1-234/235.0
NLAKNQTDVYPILDATLVKD--PAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKTTGSFLYYGE
|. ||.   ... | | ||     .|  |.| . |   . .  ... | |     |.|||  ..|.| . ..|.  |..      ...|.... .|.||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MFVNVRkvEKMDEERSRYTIE--VLPNGFSNS--VMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSN--GSEKLLVVSKNGCGRAGFFITLGAAF
..|...  ||  |. ..||..   | .  ..|   ..... .|.|.  |||    ....|..|... |..|.   |....|....|.||.| |..| ...
ikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp....espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

CCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLL
..|....|. . .||| .|.|||..|.|..||. || ..|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 174-401 2.5e-39 130.5 In-house 1-234 (235) alignment
Range on Protein: 174-401
Range on HMM: 1-234/235.0
NLAKNQTDVYPILDATLVKD--PAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKTTGSFLYYGE
|. ||.   ... | | ||     .|  |.| . |   . .  ... | |     |.|||  ..|.| . ..|.  |..      ...|.... .|.||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MFVNVRkvEKMDEERSRYTIE--VLPNGFSNS--VMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSN--GSEKLLVVSKNGCGRAGFFITLGAAF
..|...  ||  |. ..||..   | .  ..|   ..... .|.|.  |||    ....|..|... |..|.   |....|....|.||.| |..| ...
ikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp....espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

CCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLL
..|....|. . .||| .|.|||..|.|..||. || ..|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0042113 (Phosphotyrosine protein) phosphatases II 167-405 3.8e-38 126.7 In-house 2-244 (245) alignment
Range on Protein: 167-405
Range on HMM: 2-244/245.0
NCTVWKKNLAKNQTDVYPILDATLVKDPAKP----DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKt
... ...|  ||.   ....| |.|| .  .    ..|.|.| | .....  ....| | ..  | |||  ..... .   |   |.      . ..|  
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

tGSFLYYGEMFVNVRKVEKmDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKS---SNGSEKLLVVSKNGCGRAGFFI
 |..|.||...|.....|. ...  ..|.|| ..| . | . ..| ...|. .|||    .......|...||..   .......|| .. |.||.| ||
.gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvp....dllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

TLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
..  ....|. . .  . |.|| .|||||.||..  ||  || .||...|
aaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 218-408 3.9e-35 115.1 In-house 123-313 (346) alignment
Range on Protein: 218-408
Range on HMM: 123-313/346.0
GQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDEKY---DFFPKTTGSFLYYGEMFVNVRKVEKMdEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVP
 |. .  . |.||   |.||. ..|..|  .  |     .|    | . | | ||.| |. .    .   |||||||.| |.||. .|. |. |  .  |
pqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvs.gdpkeytievlpegnsdsvicqvhhhapwkhlqqp

IRyantTRSVVDVMNFVKSSN--GSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKI
 .    |  .. ..   .| .   .  . |||  |||||  ||    |   ||.  || | ||.|.|. ||| .|||. ||||.|  .. || .| 
pk....tlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkr

0037934 (Phosphotyrosine protein) phosphatases II 168-404 1.7e-24 82.2 In-house 4-242 (243) alignment
Range on Protein: 168-404
Range on HMM: 4-242/243.0
CTVWKKNLAKNQTDVYPILDATLVKDpaKPDSYVNMSSVIVPHcsYpILMGQIPKRGLEEE----FWRAAYNEQV---VMMYVLVGSEDEKYDFFPKttG
.  .. || ||.   .. .| . ||   ....|.| . . |.   . .  .| |  .  |.    |||  .....   ||.  ||  . ||.. .    |
iallpenlsknrysdilpydhsrvkl..egsdyinanliyvtp..r.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..g

SFlYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKS------SNGSEKLLVVSKNGCGRAGFF
.. .||...|.. ..| .|.   |.   . ..    . .   | ...|  .|||   ..  . . .| .|...       ......||  . |.||.| .
ev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

ITLGAAFCCLndnsEPRIGEIVKAIRSQRPN-AVESIKQYASLYLCLLYYI
|..     .|    .  . |.|| .|.|||. ||..  ||  || .||...
iaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell

0045098 (Phosphotyrosine protein) phosphatases II 168-406 6.8e-24 80.2 In-house 27-274 (278) alignment
Range on Protein: 168-406
Range on HMM: 27-274/278.0
CTVWKKNLAKNQTDVYPILDATLVKdpakpDsYVNMSSVIVPhcSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE---K-YDFFPKttGSFL
. .. .||.||    .. .| . ||     | |.| | . ..  .   .. | |.    . |||  .....     | . ..    | . ..|   |..|
palylgnldknRykdilpydhsrVk.....d.YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsl

YYGEMFVNVRKVEKMdEERSRYTIEVLPN----GFSNSVMMNVYVHTGWEPFGVPIRY-ANTTRSVVDVMNFVKS------------SNGSEKLLVVSKN
.||...|.. ..| . ..    |..|           |  ....  ..|. .|||     .   .... .. . .             ..... ||  . 
tygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GCGRAGFFITLGAAFCCLndNSEPRIGEIVKAIRSQRPN-AVESIKQYASLYLCLLYYIKK
|.||.| .. .    ..|  ..   . |.|| .|||||. ||..  ||  || .||.....
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 199-410 4.2e-21 70.4 In-house 77-295 (325) alignment
Range on Protein: 199-410
Range on HMM: 77-295/325.0
SYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAA--YNEQVVMMY-VLVGSEDEKYDFFPKTTGSFLYYGEMFVNVRKVEKMDEERSR-YTIEVLPNGF
 |.| | .         |  | |.    ...|| .  ..  ||..  .| . .|.   ..||  |    .| . |..| .|.. .   | . .    .| 
dyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGe

SNSVmmNVYVHTGWEPFGVPIR---YANTTRSVVDVMNFVKS-SNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESI
. ||  . . . .|. .||. |    .. .. |  | . |.. ...|  .||   .| ||.| ||.| .|   . ..|.  | . || .| .||. ||..
trsv..kqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetv

KQYASLYLCLLYYI-KKKITV
 ||  .| .|  ..   .  |
dqyiliyealveaymsgntdv

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 194-405 2.2e-20 67.9 In-house 71-280 (288) alignment
Range on Protein: 194-405
Range on HMM: 71-280/288.0
PAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKYDFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRYTIEVl
  .   |.| | . . . .   .  | |     ..||.  |...   .||.  ||  ...| . .  ...    ||.. | .........   |  . . 
eeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.

pnGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNGSE--KLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVE
     . . .. | ...|   |||    . .. ...... || .| ..  ...|.  .| ||.| ||.| |.   .. .    . ..|. .| ||.. |.
..kkkteleitqyqylaWpdhgvP....eskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvq

SIKQYASLYLCLLYYIK
  |||  .| .||  |.
tlkqYefiyevllslie

subfamily_PTPN23_pd Subfamily PTPN23 160-406 1.1e-19 65.4 In-house 29-282 (288) alignment
Range on Protein: 160-406
Range on HMM: 29-282/288.0
ATKANIENCTVWKKNLAKNQ-TDVYPIlDATLVKDPAKPDSYVNMSSV--IVPHCSyPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDEKY----
. .|.   ... |..  ||. .|. |  | . ||   . | |.| | |  ..| |  .... | |...   .||.  |.... .. .|.  |. .     
dkearkrsiaiaklyseknrsrdilPy.DhnRvklrgskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvd

DFFPKTTGSFLYYGEMFVNVRKVEKMDeERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFV-KSSNGSE-KLLVVSKNGCGR
 ..|. .|    .|.. | ...|.... . .......  .. ..  ..     | |  .|||    .  . .  | .   .  . |.  |.|    | ||
rYwPedkgetvkfgdlsvtlksvrete.thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgR

AGFFITLG-AAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
.| |  .  |.    ..|  . | ..|. .| || . |.  .|.  .|   | ....
tgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 153-419 2.8e-19 64.4 In-house 27-300 (305) alignment
Range on Protein: 153-419
Range on HMM: 27-300/305.0
EYIDVCVATK-ANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKP-DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLV----G
.|  ..   .  .... .. |.. . ... ...     | ... ..   |.| | |   . .   .. | | .   ..|||  ..|.|. .  |.    |
qykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveg

SEDEKYDFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiRYANTTRSVVDVMNFVKSSNGSEKLLVVSKN
 .|  . ..|....    .||. |...  ... .   |       .. ..|  .  |  | |   ||| ..| .  |... ..  ....    |||.  .
gkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvp.qfatsllslikrvqkdqkkdkgvpllVhCsa

GCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKI--TVPEGLQQKVE
| ||.| ||..  |.  |.   .  . |..|..||.|...|.. .|| .|.  |  .|.      . . |. .|.
gvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvn

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 197-405 3.2e-19 64.1 In-house 36-243 (250) alignment
Range on Protein: 197-405
Range on HMM: 36-243/250.0
PDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNE---QVVMMYVLVGSEDEKYDFFPKTTGSflYYGEMFVNVRKVEKMDEERSRyTIEVLPNG
   |.| | . . . .   .. | |     |.|||  ..|    .||.  |. || .  ...|  .     ||.. |.. . |.. .  .| .. .  . 
esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae..kyGdvtvsllskeefadytkr.klklskak

FSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNGS---EKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESI
 ......  . .. |   |||    .....|..... |..|.       ..|   .| ||.| ||.. | .  |. .    . ...|..| .||.|||| 
kaderivrqlhfvvWPdkgvP....evatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesl

KQYASLYLCLLYYIK
.|| ..|  .| ...
eqyvfvyeiilkald

PTPc_DSPc_SM00012 300-402 4.9e-19 63.9 In-house 2-105 (105) alignment
Range on Protein: 300-402
Range on HMM: 2-105/105.0
MNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDN-SEPRIGEIVKAIRSQRPNAVESIKQYASLYL
...| .|||  .||| .  . .. . .|... . |. |. ..|....|.||.| |..|  . . |... .|. | .|||..|.|||..|..  ||  || 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CLLY
.||.
alle

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 196-405 3.2e-18 61.0 In-house 82-291 (298) alignment
Range on Protein: 196-405
Range on HMM: 82-291/298.0
KPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKY-DFFPKTTGSflYYGEMFVNVRKVEKMDEERSRyTIEVLP
.   |.| | .   . . . .. | |     |.|||   .|.   .||.  |. ..  ||  ..|..      |||. |.... |.. .  .| ...|  
eesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivr.klkvsk

NGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFV---KSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVE
.  ... ..    .| |   |||    ....||.|... |   .. .| . ..|   .| ||.| || . . .  .. ..   . ..||..| .||.||.
kkeekerevrqlhftsWpdkgvp....enatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavq

SIKQYASLYLCLLYYIK
. .||. .|   | ...
teeqYvfiyeavleald

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 221-407 6.2e-18 59.7 In-house 72-267 (270) alignment
Range on Protein: 221-407
Range on HMM: 72-267/270.0
PKRGLEEEFWRAAYNEQV---VMMYVLVGSEDEKY-DFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRYT-IEVLPNGFSNSVMmnVYVHTGWEPFGVPI
|.    ..|||  ..|.|   ||.  |.    .|   ..|. ... . . .....|.....  || .. | ...  .| .. ..   . .. |   ||| 
PlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpr

RYA--NTTRSVVDVMNFVKSSNGSE----KLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
.     .|.... ... |. |. .      |||   .| ||.| .|.|  |...|. ...  . .|....| .|.. |.  .||. ||  .. |....
eedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 193-433 1.3e-17 58.1 In-house 66-307 (515) alignment
Range on Protein: 193-433
Range on HMM: 66-307/515.0
DPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVL-VGSEDEKY---DFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRyTIE
. .    |.| | .   ..    .  | |..   ..|||  ..|.|  . ..   .|..|     ..|.  |  . .|.. |..  .|   .   | ...
ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikr.klt

VLPNGFSNSVmmNVYVHTGWEPFGVPIRyantTRSVVDVMNFVKSSNGS--EKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNA
|| .  |. |    .  |.|   ||| .    |.|.. ..  ||...|     |..    | ||.| .|..       ..     . ..|. || .||  
vlkgddsrtv..tqfhfteWPdkGvpkh....tssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpyl

VESIKQYASLYLCLLYYIKKKIT-VPE-GLQQKVEDLKRGLEGITREDL
|    ||| .|  .| ... . | .|   . ....||.   .|  |  .
vqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskm

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 191-434 1.4e-17 58.5 In-house 65-309 (315) alignment
Range on Protein: 191-434
Range on HMM: 65-309/315.0
VKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLV-GSEDEK---YDFFPKTTGSFLYYGEMFVNVRKVEKMDEERSRYT
| |    . |.| | .   ..    .  | |..   ..|||  ..|.|  . ..   .|..|     ..|.  .    .|.. |.. ..|   .   |  
viddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl

ieVLPNGfSNSVMMNVYVHTGWEPFGVPIRYAnttrSVVDVMNFVKSSNGSEK--LLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRP
  |. ..  .|  .  .  |.|   ||. . .    |.. ..  ||..||...  |||    | ||.| .|..      .....   . ..|| .|..||
..vtrks.eesrtvtqfqftewPdkGvdkqts....sllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrp

NAVESIKQYASLYLCLLYYIKKKITV--PEGLQQKVEDLKRGLEGITREDLT
  | . ..|| .|  .| ... . |.     . ....||.   .|  |  .|
ylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmt

subfamily_PTPRB_pd Subfamily PTPRB 173-407 2.5e-17 57.9 In-house 50-288 (293) alignment
Range on Protein: 173-407
Range on HMM: 50-288/293.0
KNLAKNQTDVYPILDATLVKD----PAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKYD-FFPKTTGSFlY
.| |||.       |.. ||       . . |.| . .   ..    .  | |  .  ..|||  ....   .||.  ||    .| . ..|... .  .
vnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.l

YGEMFVNVRKVEKMDEERSRyTIEVLPngFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFV----KSSNGSEKLLVVSKNGCGRAGFFITLGAA
||.. |.. . |....   | ....     ...  .. | .| |  .|||    ..|....| .. |    .... .. ..|    | ||.| ||.|   
yGdikvtlvaeeeledwvir.elkiek..ekeerkvrqyhftsWpdhgvP....ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrl

FCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
.  ....    |  || ..|..| . | . |||  .. |.| ...||
lqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk

subfamily_PTPRA_pd Subfamily PTPRA 214-404 1.1e-16 55.6 In-house 102-296 (330) alignment
Range on Protein: 214-404
Range on HMM: 102-296/330.0
PILMGQIPKRGLEEEFWRAAYNE---QVVMMYVLVGSEDEKYDFFPKTTGSFlYYGEMFVNVRKVEKMDEERSR-YTIEVLPNGF--SNSVMMNVYVHTG
  .  | ||.   |.|||  ..     .||.  |   ..||   .  . |..  ||.. |.|.... . .   | . .. ||..    .| ... .  |.
kfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlv.tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhfts

WEPFGVPIryanTTRSVVDVMNFVKSSNGS--EKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYY-I
|  .|||.    ... ...... ||. |    . . |    | ||.| ||.| | .  .. .    . |.|| .| |||. | . .||  .|  || | .
wPdvGvPf....epiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl





subfamily_PTPRD_pd Subfamily PTPRD 223-422 1.1e-16 55.6 In-house 101-301 (564) alignment
Range on Protein: 223-422
Range on HMM: 101-301/564.0
RGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKYD-FFPKTtGsFLYYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPirya
    |.|||  ....   .||.  |. .. .|.. ..|.. |    |||. |.. . |.. .   | |...  .  |.| . . . .| |   |||    
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeir.tfklkkkkssesreVrqFhFtsWPdhgvp....

NTTRSVVDVMNFVKSSNGSEK--LLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITV--PEGL
....|..|... |...| ...  ..|   .| || | ||.. |    ....    | ..|||.|.||.  |.. .||. ..  .| ....  |    | |
esatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenl

QQKVEDLK
.|... |.
kqhlqkLa

subfamily_PTPRK_pd Subfamily PTPRK 199-401 1.4e-16 55.2 In-house 72-274 (314) alignment
Range on Protein: 199-401
Range on HMM: 72-274/314.0
SYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSE-DEKYDFFPKTTGSflyYGEMFVNVRKVEKMDEERSR-YTIEVLPNG
 |.| . .   . .   .. | |..   ..|||  |.|.   .||.  ||     . . ..|. |     ||.. |.. ..|   |  .| ...| |  |
dyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklarg

FSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSsnGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQY
 ..  ... . ..||  ..||       . |  | .  .   .  ...|   .|.||.| ||..      .. ..   . ..||..||...| ||  .||
qeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqy

ASLYLCLL
  .|  .|
kfiydvil

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 154-408 1.6e-16 55.3 In-house 29-287 (319) alignment
Range on Protein: 154-408
Range on HMM: 29-287/319.0
YIDVCVATKANIENCTVwKKNLAKNQTD-VYPiLDATLVKDPA---KPD-SYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGsE
. ..  |.. ......  ..|  ||.   . .  | | |. ..   ...  |.| | .   .     .  | |.    |.|||  ..|.. .. .| .  
fkllkeavndtfdsask.eenkkknryqnila.ydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltk.l

DEKYDF-FPKT--TGSFLYYGEMFVNVRKVEKMDE-ERSRYTIEVLPNGFSNsVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSN---GSEKLL
 || .  . |.  .  |  ||.. |.. . |.... . .. ... . .      ..  . .| |   .||    ....|..|... .. |     |  . 
veklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevet.RevkhfqyteWpdhdvP....ekatslldllkrirksrektqsgPiv

VVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKI
|   .| || | ||.| |..  .. ..   . ..|. .| ||.  |.  .||  .|  || ...   
vhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 153-404 1.9e-16 55.1 In-house 28-284 (297) alignment
Range on Protein: 153-404
Range on HMM: 28-284/297.0
EYIDVCVATKANIENCTVWKKN--LAKNQ-TDVYPIlDAT---LVKDPAKPDS-YVNMSSVivPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLV
.....    .||| . || .|.  . |.. ... |. |     |     .||| ||| | |  .   . ..  | |..   ..||.  ..||| .. .| 
fseeflclpeaniqpqtvaekkvnfeksRYkniLPy.dssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmln

G--SEDEKY-DFFPKTTGSFlyYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRyaNTTRSVVDVMNFVKSS---NGSEK
    .|.|   ...... .   .|.. | .  |..      | ..||  .   .  ... | .. |    |. .  ....|...... |. .   | .  
ddnerdkkcaryWsdkgvtt..fGdvsvvllsvsereGfikr.elevtkgkakarrvvkqyqfveWPdkaverk..dsassllklisevrkdfsqnaegP

LLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYI
|||   .| ||.| ..|.    .  ... |  | ..|| .| .||. |   .||. .|  .| ..
llvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal

subfamily_PTPN12_pd Subfamily PTPN12 190-410 7.7e-16 52.8 In-house 59-283 (290) alignment
Range on Protein: 190-410
Range on HMM: 59-283/290.0
LVKDPAK-PDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQV---VMMYVLVGSEDEKY-DFFPKTTGSFLYYGEMFVNVRKVEKMDEERSR
| |.  .  ..|.| ...  .. .   .  | |     ..|||  .. .|   ||.  .|  .  |   ..|..... | .||. |.. . ...|..   
lskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddfli

YTIEVLPNgfSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKssNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEP---RIGEIVKAIRS
 |..|  .  ..| ... . .| |   ||| .  .  . . .| .. .  . .. |.|    |.||.|  |..  .   |...  |    . ..|  .| 
rtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrk

QRPNAVESIKQYASLYLCLLYYIKKKITV
||. .| . .||  .| ... ...|....
qraalvqtkeqyelvykavaelvqkelei

subfamily_PTPN14_pd Subfamily PTPN14 144-406 2.3e-15 51.4 In-house 19-298 (300) alignment
Range on Protein: 144-406
Range on HMM: 19-298/300.0
KLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQ-TDVYPILDATLVKDPAKP--DSYVNMSSVIVPHCS--YPILMGQIPKRGLEEEFWRAAYNEQV
||. ..  .||  .    .  . ...  ..|  ||.  || |  |. .   |.|   . |.| ||. |. ..  .  .. | | .   ..||.  ....|
kleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgv

VMMYVLVGS-E---DEKYDFFPKT--TGSFLYYGEMFVNVRKVEKMDEE-RSRYTIEVLPNGFSNSVMMNVYvhTGWEPFGVP------IRYANTTRSVV
 ..  |  . |   .  . .|||.    . . .|.  |  . .|. |    . .... || .   .|..  |  | |   |||      . | .  .|| 
qlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvr

DVMNFVKS-SNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
  .|  ..  . .  .||   .| ||.|  |.      .|. | |  | .... .| ||   |... ||  .|  |. |.|.
rktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 200-402 4.9e-15 50.8 In-house 55-253 (284) alignment
Range on Protein: 200-402
Range on HMM: 55-253/284.0
YVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVgsEDEKYDFFPKTTGsfLYYGEMFVNVRKVEKMDEeRSRYTIEVLPNGFSN-SV
|.| | .         .  | |.    ..|||  .. ..  . .|   .|   ...|. .     .... |.|  ||. .|      ||.  .|  .   
yinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplkiv..ikeerfkvkvdsveesee.yvvrdielsedgkekdir

MMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYL
 .. .   ||   |||   ..  | |  |  . .  |. ....|    |.||.| .|.| . .  .....   . ..|. .| ||.. |... ||  .| 
kirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

CLLY
 || 
alle

subfamily_Ptp69D_pd Subfamily Ptp69D 174-407 5.9e-15 50.2 In-house 48-289 (307) alignment
Range on Protein: 174-407
Range on HMM: 48-289/307.0
NLAKNQTDVYPILDATLVKDP----AKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYnEQVVMMYVLVGSEDEKYD-----FFPKTtgSFLY
|. ||. .     | | || .     .  .|.| | ..  . .   .. | |  .  ..|||    || | . |..  ..|| .     ..|.       
nalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmia.eqevtlivmlsnlteknrkkcakYWpie..devq

YGEMFVNVRKVEKMDEERSRyTIEVLPNG-----FSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSngSEKLLVVSKNGCGRAGFFITLGA
||.. |.. . ||...   | ...|  ..       .|  .  | .|||. . ||       . .  | .  | .     ..|  ..| ||.| |..|  
ygdilvklvseekhsdyiiR.eldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPivvhCsaGvgrsgifvalds

AFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
 .  |. . .  | |.|| .||||.  |.|..||  ||  || |... 
llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 200-402 6.1e-15 50.3 In-house 91-289 (319) alignment
Range on Protein: 200-402
Range on HMM: 91-289/319.0
YVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVgsEDEKYDFFPKTTgsFLYYGEMFVNVRKVEKMDEeRSRYTIEVLPNGFSN-SV
|.| | |         .  | |.    ..|||  .. ..  . .|   .|   ...|. .     .... |.|  ||. .|      ||.  .|  .   
yinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplki..vikeerfkvkvdsveetae.yvvrdielsedgkekdir

MMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYL
 .. .   ||   |||   ..  | |  |  . .  |. ....|    |.||.| .|.| . .  .....   . ..|. .| ||.. |... ||  .| 
kitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys

CLLY
 || 
alle

subfamily_PTPN3_pd Subfamily PTPN3 171-400 8.8e-15 49.4 In-house 38-271 (280) alignment
Range on Protein: 171-400
Range on HMM: 38-271/280.0
WKKNLAKNQ-TDVYPiLDATLVKDPAKPDSYVNMSSVIVPHCSYPI----LMGQIPKRGLEEEFWRAAYNEQVVMM---YVLVGSEDEK-YDFFPKTTGS
  .||.||.  |. |  ||| ||  . .  |.| . | .   |  .    .  | | .   ..||.  ..... ..     || .   | . ..|.|. .
kpenlsknryrdilp.ydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetede

fLYYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSngSEKLLVVSKNGCGRAGFFITLGAAF
 | |||. |...| ..  .   |  . .  .  ... ..    .. |   |||   |.  . |  | .  ...  .| ..|    | ||.| .|.|  |.
.leygefsvkcekedetksyvlr.elvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgk..eePvvvhCsaGigrtGvlilletal

CCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCL
. .. . .  . .||. .| || . |.. .||  .  ..
alieaaepvypldivrtmrdqramlvqtasqykfvCeai

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 161-407 1.5e-14 48.8 In-house 30-274 (288) alignment
Range on Protein: 161-407
Range on HMM: 30-274/288.0
TKANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSsvIVPHCSY--PILMGQIPKRGLEEEFWRAAYNE---QVVMMYVLVGSEDEK-YDF
 .|.|.  ... .| .... .  |  |.| ||    || |..    .|.   |   ..  | | .|  ||.|.   ..    .||.  |.    ||  ..
neasidiidsfianptrdryenlprcditrvklsddpdfyiaan..vvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaey

FPKTTGSFLYYGEMfVNVRKVEKMDEERSR-YTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRsvvdVMNFVksSNGSEKLLVVSKNGCGRAGF
||   |    .| .  .| |... | ..    ..    .   ..|.. .     |.  |||  |    |    ... .   .  . ..| |..| ||.| 
fPsklGekarigrl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplr....llevl..kslqkPivvhssaGvGrtgt

FITL--GAAFCCLNDNSepRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
.|     .   .|.|..   | ....  | .| .|... .||  .. |.|...  |
lililialeslrlddfl..girsllaklreerfkaiqtemqylyvhrcvleelllk

subfamily_PTPN13_pd Subfamily PTPN13 145-405 2.5e-14 48.2 In-house 8-270 (273) alignment
Range on Protein: 145-405
Range on HMM: 8-270/273.0
LDASQTRPEYIDVCVaTKaNIENCTVWKK--NLAKNQ-TDVYPIlDATLVKDPAKPDsYVNMSSVI--VPHCSYPILMGQIPKRGLEEEFWRAAYNEQvV
||  |   |. ..    |  ...|.| ||  | .||.  .| |. |.| ||  ..   |.| | .   | .  |  .. | |     ..||.  .. . .
ldqqqPaeefkelre.lk.pldtcevgkkkenkdknryrnvlPy.detrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk.a

MMYVLVGSEDEK-----YDFFPKTTGSFLYYGE-MFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKs
 . ..| .| ||       ..|..... |   . . |.. ||.|.|.   | ...|  .  ..|  .     . |   |||   |.  . |  | .. . 
eviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvr.alavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.

snGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
   .  ..|    | ||.| .||. ...  .. . |  . |||. .| ||   | . .||   |  .|. .|
..dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 199-401 4.5e-14 47.1 In-house 78-276 (315) alignment
Range on Protein: 199-401
Range on HMM: 78-276/315.0
SYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKYD-FFPKTtgsFLYYGEMFVNVRKvEkmdEERSRYTIEVLPNGF
 ||| . .         .  | |.    ..|||  ..|.   .||.  ||  | .| . ..|      . ||.. |  .. |   |  ..||.  |   |
dyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrks.e...evnteytvrtlsvvf

SNSVMMNVYV-HTGWEPFGVPIRYANTTRSVVDVMNFVKSSNgsEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQY
 . .   | . .| |   |||    .    .  |. . ..|     ..|  ..| ||.| |||| | .  .. .    . .... .|..| ..|....||
gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqy

ASLYLCLL
  .|  ||
qfiydall

0041856 (Phosphotyrosine protein) phosphatases II 174-411 6.6e-14 47.4 In-house 1-178 (182) alignment
Range on Protein: 174-411
Range on HMM: 1-178/182.0
NLAKNQTDVYPILDATLvkdpakPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVgseDEKYDFfpkttgsflyygemfvnvr
|| || .  ..  | ..      . .|.| . .. .. .  ... | |  .  ..|.|  ..... .   |    .| |.                    
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywp...................

kvekmdeersrytievlpN-GfsnSVMMNVYVHTGWEPFGVPIryantTRSVVDVMNFVKSsnGSEKLLVVSKNGCGRAGFFITLGAAFCClndnsEPRI
                  .       .   |....|. .|||      .....| .. |..   ... ||  . |.||.|... .    ..     .  .
..................ell...erlgiqylylpwpDhgvpd.....ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsl

GEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVP
 |.|| .||.||..|..  ||  |.|.||.... |.|.|
eeavklvrsrRpgmvitpnqyfflqlallellllkktrp

subfamily_CG7180_pd Subfamily CG7180 198-404 7.2e-14 46.1 In-house 70-290 (296) alignment
Range on Protein: 198-404
Range on HMM: 70-290/296.0
DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDEK--Y-DFFPKTTgsFLYYGEMFVNVRKVEKMDEERSRyTIEVLPN--
. |.| . |         .. . ||.   .||||  |.|..  . ||    | .  | ...|...     |||.||.. ..... . ..| |. .  .  
sdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks..keqygeifveiveekqyanlkir.tfkltkkiv

--G-----F-SNSVMMNVYVHTGWEP-FGVPIR---YANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIR
  .        .  .. ..  | ||    ||.    . .  | |  ... |.  .  . ..|||..| .|.| .... |.   .. . |  . | || .|
alteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlr

SQRPNAVESIKQYASLYLCLLYYI
 .||. ||....|  .|  || ..
rsRpqLvenveeYkyiYdvlleav

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 224-424 1.6e-13 45.4 In-house 100-302 (318) alignment
Range on Protein: 224-424
Range on HMM: 100-302/318.0
GLEEEFWRAAYNEQvVMMYVLVGSE----DEKYDFFPKTTGSfLYYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYAN
   |.|||  .. .  .. |..  |     .| . .    ||   ||.. |....  ....   | ...|  .. ..| ..  | .| |   |||   |.
etieDfWrmvWeqn.savivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlr.efkvtrteeeesrqvrqyhytsWpdegvpesgas

TTRSVVDVMNfVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITV--PEGLQQK
    | .| . .. ..| . ..|    | ||.| ||.. .    .....   . ..|| .|.||.  |   .||  .|  || ...   |    . |...
lldlvrqvsk.aqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsr

VEDLKRG
...|.. 
irelreq

subfamily_PTPN9_pd Subfamily PTPN9 139-406 2.2e-13 44.9 In-house 7-292 (297) alignment
Range on Protein: 139-406
Range on HMM: 7-292/297.0
VAYIGKLDASQTRPEYIDVCVATKANIENCTVWKKNLAKNQTDVYPILDATLVKDPAKP----DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAY
|||. . . .  . ||...   . .   ...  . || ||.      .| | |. . ..      |.| . |   .    ..  | | .   ..|||  .
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvW

NEQVV---MMYVLVGSEDEK-YDFFPKTTGSFLYYGEMFVNVRKVEKMDEER-SRYTIEVLPNGFSNsvMMNVYVHTGWEPFGVPIRY------ANTTRS
...|.   |.  .|     |   ..|....|   .|.. |.. .||.... . . ..|.   .. |    .  .  ..|  .|||          .. |.
eqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesr..kvthfqflsWPdyGvPssaaslldvlekvre

----VVDVMNFV-KSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
    .|. .    |       ..|    | ||.| ||||  .   |.. .   . | || .|.||  ..   .||.  ||..| | ..
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 161-406 1.1e-12 42.6 In-house 21-261 (267) alignment
Range on Protein: 161-406
Range on HMM: 21-261/267.0
TKANIeNCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVL-VGSEDEKYDFFPKTT
|...|  . . .|| ..|. |     | | |    | . |.| | |   .     .. |.| .    .|.    ...| .. .|    .|.   |.|   
tssti.sqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkm

GSFLYYGEMFVNvRKVEKmdeERSRYTIEVLPNGFSNSVMMNVYVHTgWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGA
|    | .. |. . .||   |   | | .|   | |    || ..  .. . .        . .. ..   .  ||.  |.|  ..| ||.| |... .
gqakkyqdltve.hslek...eendyqiitlelkfknesahnvtlyy.ykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvids

AFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
 .  .  ..   | . .. |||||.  |..  .|  ..  |  | . 
qleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 196-406 1.2e-12 42.4 In-house 71-285 (290) alignment
Range on Protein: 196-406
Range on HMM: 71-285/290.0
KPD---SYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVG-SEDEK---YDFFPKTtGSFLyYGEMFVNVRKVEKMDeERSRYTIE
..|   .|.| . .   . ..  .. | |      .||.  ..|.| .. .|.   |..|   . ..|.. ..   |||. ... . |... |  . ..|
hkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetln.eyierkle

VLPNGF-SNSVMMNVYVHTGWEPFGvPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAV
|  .    .. ..  |  | |.. |  .   .|  .|.  |.  .  .| . ..|   .. ||.. |...  .    . .    . ...|  |.|.|. |
vknknsagakqsvtqyqitnwdstg.kvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsv

ESIKQYASLYLCLLYYIKK
.. .||  ..  .| |...
qtvqqyqgifqivltylds

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 176-403 1.7e-12 41.6 In-house 58-282 (290) alignment
Range on Protein: 176-403
Range on HMM: 58-282/290.0
AKNQTDVYPILDATLV--KDpAKPDSYVNMSSVivPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYV---LVGSEDEK-YDFFPKTTGSFLYYGEMF
 ||.    .  | | |  ||   .  ||    |       .... | . .    ..||   .|.| .. .   |.     |  ...|.. |  | .||. 
kknrykdvvcndktrvilkd.GydGdyvhanyv..kGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeit

VNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVpiryANTTRSVVDVMNFVKSSNGSekLLVVSKNGCGRAGFFITLGAAFCCLNDNSE
|   . .. |..  . |. |       . ... .    |    |    |..| ... ..  ..  .|   . |    | ||.| |... ..  .| |  |
vlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv....alstlallrtlrilrkasGp..vvvhcsaGiGrtGtfvaievglqilldGke

PRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYY
 .. ..|.|.|  | |.|.   ||  |   || .
ldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_PTPRG_pd Subfamily PTPRG 216-422 2.2e-12 41.0 In-house 94-303 (563) alignment
Range on Protein: 216-422
Range on HMM: 94-303/563.0
LMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKYDFF-PKttGSFLYYGEMFVNVRKVEKMDEERSR-YTIEV--LPNGFS--NSVMMNVYVHT
.. | | .   . |||  ....   .||.  || .. .| | . ||     . ||.. |.  . |..    .|  .|.   | .. .  .  ..  |  |
iatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhyt

GWEPFGVPIRYANTTRSVVDVMNFVKSSNGseKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
 |   |||   .     |.      |.  |   ..|  ..| ||.| .| | .    .....   . ...| ||.||.. |... ||  |.  ||  |. 
kWPdhgvPehslpvLifvkkssaankaeaG..PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

KITvpEGLQQKVEDLK
| |  | |...||.||
ket..ellaeqveelk

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 198-407 2.4e-12 41.6 In-house 69-279 (281) alignment
Range on Protein: 198-407
Range on HMM: 69-279/281.0
DSYVNMSSVIVPH--CSYPILMGQIPKrgLEEEFWRAAYNEQVVMMyVLVGSEDEK-----YDFFPKTTgSFLYYGEMFVNVRKVEKMDEErSRYTIEVl
  |.| . |   .    | .  | .|.    ..||.  ....| .. |.|  | |.     . ..|  . | | ||.. |.  . |.  .   . .... 
tDYinanfvpgykgekeyiatqgPvPa..slvafWqmvweqkvsai.vmvtreieagklkChrYWPddn.selkygdvtvkstaeeekaty.ierkfkl.

PNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKS---SNGSEKLLVVSKNGCGRAGFFITLGAAFCCL-NDNSEPRIGEIVKAIRSQRPNA
 .  .... ..   .| |   |||    .||. ...  . |..   ..    |..    | ||.| .|.|  ..  . ....|  . ..|. .| .|   
eresgetreveqlaytaWPdhGvP....attkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlm

VESIKQYASLYLCLLYYIKKK
| .. ||. .|. .| ...|.
vqtvvqyefvykavldaldke

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 191-406 3e-12 41.1 In-house 64-280 (287) alignment
Range on Protein: 191-406
Range on HMM: 64-280/287.0
VKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVG----SEDEKYDFFPKTTGsfLYYGEMFVNVRKVEKMDEeRSRYT
|    . . |.| . .   . ..  .. . |      .||.   ...|  . .|.      |.  |...|...   ...||  ... . |....     .
vllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnag.yierk

IEVLPNG-FSNSVMMNVYVHTGWEPFGVpIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPN
.||  ..  ..  ... |  | |.  |  .   .|   |.. |.  .  .|   ..|   .. ||.. |.    .    . .    . ...|  | |.|.
levknknkagdkqqvkqyqitnWdstgk.vtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpg

AVESIKQYASLYLCLLYYIKK
.|  ..||  ..  .| |.. 
svqtveqykfindivleylds

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 167-395 5.6e-12 40.1 In-house 26-257 (283) alignment
Range on Protein: 167-395
Range on HMM: 26-257/283.0
NCTVWKKNLAKNQTDVYPILDATLVKDPAKPDSYVNMSSVIVPH---CSYPILMGQIPKRGLEEEFWRAAYNEQV---VMMYVLVGSEDEKYD-FFPKtT
.... ..|  ||. .     |   |.  ... .|.| . ..| .    .   .. | | .    .||.  ..|..   ||.  |   ...|   ..||  
diasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk.r

GSfLYYGEMFVNVRKvEKMDEERSRYTIEVLPNGF-SNSVMMNVYVHTGWepfgvpIRYANttRSVVDVM---NFVKSSNGSEK---LLVVSKNGCGRAG
||   |||. | .|| |   .  ..  . .  |.   .....  |   .|      . | .   .... .   | |.|    .|   ..|   .| ||..
Gs.edyGeftvtlrk.ettsnsfiikelllrvnssakstlllahyqvidW......leyge..qaiinslvkfnkvislqteskkgPivvhCstgiGrta

FFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYAS
 ||.. |.   .  .|   . ..|| .| ||. || .  ||  
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqykl

0051429 (Phosphotyrosine protein) phosphatases II 215-414 1.2e-11 40.4 In-house 24-235 (272) alignment
Range on Protein: 215-414
Range on HMM: 24-235/272.0
ILMGQIPKRGLEEEFWRAaYNEQVVMMYVLVGSE---DEKYDFFP-----------KTTGSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMM
.. .. | .  ...|||  ..... .   | . |    .|.|...            ..  .  || ..| . ..| ..    |. . .|  . ... ..
lyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearev

NVYVHTGWEPFGVPIRYanttrsVVDVMNFVKSsngSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPR--------IGEIVKAIRSQRPNAVESIKQ
 ....|.|  .|||  .      ........ .   ....||  . |..| |... |      ....            . |.|. .|.|||.||..  |
mhlhytdwpdhgvpqea......llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeq

YASLYLCLLYYIKKKITVPEGL
|. || .|| .... ..|..  
ylflyeallellrsllsvraey

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 227-407 1.8e-11 38.6 In-house 87-271 (274) alignment
Range on Protein: 227-407
Range on HMM: 87-271/274.0
EEFWRAAYNEQV---VMMYVLVGSEDEK-YDFFPKTTGS--FLYYGEMFVNVRKVEKMDEersrYTIEVLPNGFS-NSVMMNVYVHTGWEPFGVPIRYAN
..|||  |.|.|   ||.  |  .. .|   .||....      ||.. ..|.|. . ..    |... |    . ..  .  | .| |    .| .  .
adfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekivernd....ysvrklvlkylerersvkhywytdWPdhksPddant

TTRSVVDVMNFVKSSNGS-EKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
  . | .| .  ...|      .|    | ||.| ||.   |   |....   . .||  .| .|   |.. .||  ..  |  | |. 
lldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl

0036282 (Phosphotyrosine protein) phosphatases II 215-397 2.9e-11 38.8 In-house 19-163 (174) alignment
Range on Protein: 215-397
Range on HMM: 19-163/174.0
ILMGQIPKRgleeeFWRAAYNEQVVMMYVLVGSEDEK----YDFFPKttgsflyygemfvnvrkvekmdeersrytievlpNGFSNSVMMNVYVHTGWEP
.. || | .     ||.  ..... .   |  ..  .    ....|                                   .  . . .   |....|. 
liagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lredlerlgiqylylpwpD

FGVPIRYAntTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNdNSEPRIGEIVKAIRSQRPNAVESIKQYASLY
.|||       ...|. .. . |.... ..||  . |.||.|... .    ..|  .|   . ..|...|.|||..|..  ||  ||
hgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 193-404 3.8e-11 37.1 In-house 70-279 (439) alignment
Range on Protein: 193-404
Range on HMM: 70-279/439.0
DPAKPDS-YVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVgSEDEKYDFFPKTTGsfLYYGEMFVNVRKVEKMDEERSRyTIEVLP
 |  | | |.|   .   .     .  |.||.   ..|||  .....| . .|     | | ..|  .    .||.. | | .  .. .   |  . |. 
ipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmlt.nlvesykywpsdae..vcygdiavrvdrnielpnyvir.gfkvfn

N--GFSNSVMMNVYVHTGWEPFGVPIRyantTRSVVDVMNFVKSSNGSEK---LLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNA
.     .   .  . .. |    || .    .  |.| .  ..|.| .|.   ..|    | ||.|  |.|  |.  |. . .  |  ||| .| || . 
erdttekertvlqfhyiawpdknvpaq....ashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqm

VESIKQYASLYLCLLYYI
|... ||  .| ..|  |
vqalcqyvfiynavledi

0043147 (Phosphotyrosine protein) phosphatases II 198-397 7.4e-11 37.6 In-house 5-154 (172) alignment
Range on Protein: 198-397
Range on HMM: 5-154/172.0
DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSedekydffpkttgsflyygemfvnvrkvekmdeersrytievLPNGFSNS
. |.| | . ....   ....| | |   ..|||  ..... . . | .                                           | ..   .
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydpelle

VMMNVYVHTGWEPFGVPirYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLndnsepRIGEIVKAIRSQRPNAVESIKQYASLY
 .   | ...|. .|||   ..  ..... .. .   . ... ||  . |.||.|... .    ..|       . |.|. .|..||.||..  ||  ||
rlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyrfly





0046846 (Phosphotyrosine protein) phosphatases II 263-406 7.4e-11 37.6 In-house 77-175 (176) alignment
Range on Protein: 263-406
Range on HMM: 77-175/176.0
LyygemfvnvrkvekmdeersrytievlpngfsnsvmmnVYVHTGWEPFGVPIRyaNTTRSVVDVMNFVKSSNgsEKLLVVSKNGCGRAGFFITlgaafC
.                                       | |..|. .|||    .   .... .. . ...  .. ||  . |.||.| ..      .
i......................................qylhlpwpDhgvpdl..elllellefirealkeg..gpvlVHCsaGigRtgtlva.....a

CLND-NSEPRIGEIVKAIRSQRP-NAVESIKQYASLYLCLLYYIKK
 |   .    . |... .|.||| .||.. .||  || ..|...||
yllelekglsveealalvreqRplgavqtpeQyrflyefellllkk

0049772 (Phosphotyrosine protein) phosphatases II 264-415 1.2e-10 37.1 In-house 167-291 (314) alignment
Range on Protein: 264-415
Range on HMM: 167-291/314.0
YygemfvnvrkvekmdeersrytiEVL--PNGFSNSVmmNVYVHTGWEPFGVPiryanTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITlgAAF
                        |.|  |. |.. .    |... .. ...|     ... . ....|... .  ...||  | |.||.| |..  ||.
k.......................eelydpelferlg..ikylripvpDgsap.....lledfdeflefieeadkggpvlvHCkaGkgRtgtfvv..aay

CCLNDnSEpRIGEIVKAIRSQRP-----NAVESIKQYASLYLCLLYYIKKKITVPEGLQ
...       . |... .|..||     ...|. .||   . .||.|.|......| |.
lmkll.gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkflkkfyeyle

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 200-405 1.7e-10 35.4 In-house 61-271 (285) alignment
Range on Protein: 200-405
Range on HMM: 61-271/285.0
YVNMSSVIVPHCSYP-ILMGQIPKRGLEEEFWRAAYNEQV---VMMYVLVGSEDEKY-DFFPKTTGSFLYYGEMFVNVRKVE--KMDE-ERSRYTIEVLP
|.  | . .|       .  | |      .||.  |.|..   .|.  |.    ||   ..|.  |  . .|.  . . ...   .        |.    
yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvinte

NGFSNSVMMNvYVHTGWEPFGVPiryANTTRSVVDVMNFVKSSNGSEKLLVV-SKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESI
.  |. . || .|.  | |  .     . .| .... ..||  |  || ..|    | ||.  |. .  |   . .| .  . .||. .|. | .||.| 
dasseplymn.hvqvpwwpdqla...pedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqsh

KQYASLYLCLLYYIK
 |.  ||. |. |. 
mqflflyvvlmeyfi

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 174-404 1.9e-10 34.7 In-house 45-236 (392) alignment
Range on Protein: 174-404
Range on HMM: 45-236/392.0
NLAKNQTD-VYPI--LDATL-VKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSED-Ekydffpkttgsflyygem
|| ||. . . |.      | | |    . |.| | .   ..    .  | |.    ..|||  ..|.|  . ..   .. .                  
nlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..................

fvnvrkvekmdeersrytievlpNGFSNSvMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNGSEK--LLVVSKNGCGRAGFFITLGAAFCCLND
                       .| ..   .  .  | |   .||    . | |.. ... ||.  |.    |..    | ||.|  |.. .  .  . 
.......................kgddar.tvaqfhftewPdkdvp....khtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakk

NSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYI
     . ..|  || .||  |.. .||| .| ..|  .
trmvdvfnfvtnirrkrpymvqtkeqyafiygavledl

0048076 (Phosphotyrosine protein) phosphatases II 263-403 1.9e-10 36.1 In-house 11-142 (145) alignment
Range on Protein: 263-403
Range on HMM: 11-142/145.0
LYYGEMFvNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSS---NgsEKLLVVSKNGCGRAGFFItlgA
||.| .  .....| . .   .. . . ..    . .   |....|. .|||    . .. . ....|...    .  .. ||  . |.||.|...   |
lylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvp....dllellleflefieealkeg..gpvlVHCsaGvgRtgtlv...a

AFCCLNDNsePRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYY
|...|  .    . |... .|||||.||..  |.  ||...|..
aylmlllg..vsleealelvrsqrpgavpnpgqlrflyefelel

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 219-397 2.2e-10 35.2 In-house 51-232 (237) alignment
Range on Protein: 219-397
Range on HMM: 51-232/237.0
QIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEK-YDFFPKTTgSFLYYGEMFVNVRKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVP
| |     ..||.  ..|.   .||.  |. ....| ....|.|      || . | ..| |.. .   |  . .      .  ..  |  | |   |||
qgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvp

IRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLY
 . |   |   ...|  .  . |   ..    | ||.| |. . | .   ...    | . |..|  .||  ...  ||  ..
qqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfih

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 227-401 2.6e-10 34.9 In-house 65-237 (239) alignment
Range on Protein: 227-401
Range on HMM: 65-237/239.0
EEFWRAAYNEQVV---MMYVLV-GSEDEKYDFFPKTTGSflyYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiRYANTTR
 .|||  ..|. .   |.  |. | . . ....| .|     | .. | .|| | . .   | |. .   | ..   .  |  | |   ||| .|| .  
gdfwrmmwqerrcvivmltglieghkkkchqywpdstsk...ycnlrvtlrktevfadyiir.tfvmsqvgqteeryvyqyhftvwpdkgvp.qyatavl

SVVDVMNfVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLL
 .   .    |  |.   ..    | ||.| |. . | .   . .    | . ||||| .||  |.. .||  ..|..|
glrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 227-401 2.9e-10 34.7 In-house 66-238 (239) alignment
Range on Protein: 227-401
Range on HMM: 66-238/239.0
EEFWRAAYNEQVV---MMYVLV-GSEDEKYDFFPKTTGSflyYGEMFVNVRKVEKMDEERSRyTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiRYANTTR
 .|||  ..|. .   |.  |. | . . ....| .|     | .. | .|| | . .   | |. .   | ..   .  |  | |   ||| .|| .  
gdfwrmmwqerrcvivmltglieghkkkchqywpdstsk...ycnlrvtlrktevfadyiir.tfvmsqvgqteeryvyqyhftvwpdkgvp.qyatavl

SVVDVMNfVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLL
 .   .    |  |.   ..    | ||.| |. . | .   . .    | . ||||| .||  |.. .||  ..|..|
glrrkit.kdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 217-407 6.7e-10 33.2 In-house 94-284 (301) alignment
Range on Protein: 217-407
Range on HMM: 94-284/301.0
MGQIPKRGLEEEFWRAA--YN-EQVVMMYVLVGSEDEKY-DFFPKTTGSFLYYGEMFVNVRKVEKM-DEERSRYTIEVLPN--GFSNSVMMnVYVHTGWE
  | | .   |.||     |. |..||.   |  . ||  ...| .... |  |   ..... |.. ... |. |.||      |.   ..  | .. | 
atqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvt.hyqysewt

PFGVPIRYANTtrsvVDVMNFVKSSNgsEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
  |||  .|..     |.|..|| |.  . ..|   .| ||.  ||.       .. . .  . | .| .| .| |.|   .|   . |  .| . |.
drgvPkshael....fdlmelvkkse..kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlike

0048179 (Phosphotyrosine protein) phosphatases II 263-398 1.2e-09 33.5 In-house 11-139 (144) alignment
Range on Protein: 263-398
Range on HMM: 11-139/144.0
LYYGEMFvNVRKVEKMDEERSRYTIEVLPNGFSNSVMMN--VYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSS-NGSEKLLVVSKNGCGRAGFFItlgA
||.| .   ....| . .   .. | . ..   ...  .   |.|..|. .|||    . .  . ....|...  . ... ||  . |.||.|...   |
lylgslp.taldlellkklgittvinlteeyepefleregiqylhlpwpDhgvp....dllellleflefieealeeggpvlVHCsaGvgRtgtlv...a

AFCCLNDNsePRIGEIVKAIRSQRPNAVESIKQYASLYL
|. ..  .    . |... .||.||.||..  |.  |..
aylmkklg..lsleealalvrsrrpgavpnpgqlrfLle

subfamily_PTPN6_pd Subfamily PTPN6 227-409 1.3e-09 32.4 In-house 112-302 (306) alignment
Range on Protein: 227-409
Range on HMM: 112-302/306.0
EEFWRAAYNEQVVMMyVLVGSEDEK-----YDFFPKTTGSFLyYGEMFVNVRKVEKMDEERSRyTIEVLP-NGFSNSVMMNVYVHTGWEPFGVPIRYANT
..||| ...|.  .. |..  | |.     . ..|... .   ||.. |.  . .....   | .. |   .  ...  .  | .. |   |||      
sdFWrmvwqensrvi.vmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilR.elsvskkkkkkeerevfqyhfksWPdhgvpkdpgav

TRSVVDVMNFVKSSN--GSEKLLVVSKNGCGRAGFFITLGAAFCCLNDN---SEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKIT
   . || .  ....   .  ..|   .| || | || . .    .. .    .  | ..|| .|.||   |   .||  .|  . .||..| .
LdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 171-404 1.6e-09 31.8 In-house 44-279 (303) alignment
Range on Protein: 171-404
Range on HMM: 44-279/303.0
WKKNLAKNQTDVYPILDATLVKdpAKPDSYVNMSSVIVPhCSYPILMGQIPKRGLEEEFWRAAYNEQVVM-MYVLVGSEDEKY--D-FFPKTtGSFLYYG
. ||. ||.      || . ||      ||.  | . .  .|   .. |.|      .||.   ...|   . .|  || .|.  |  ||.    || . 
fvknmdknrfvdvicldhskvk..lsdssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn.qdflkfe

EMFVNVRKVEKMDEeRSRYTIEVL--PNGFSNSvMMNVYVHTGWEPFGVPIR-YANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCC
| .. | .  ...     ... ||   ||  .| .. |. .  |    .|    ..  . . ..  ...    |.  . .|  |||||| |  . .|   
ersirvgefkrvel.gdgwvlkvlsvsngdyks.flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

LND-NSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYI
| . ..   .   .. .|  |  ||. . |.. .|  |  ..
lhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv

0049260 (Phosphotyrosine protein) phosphatases II 212-397 2.1e-09 32.8 In-house 8-143 (152) alignment
Range on Protein: 212-397
Range on HMM: 8-143/152.0
SYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDEKYDFFPKTTgsflyygemfvnvrkvekmdeersrytievlpngfsnsvmmnVYVHTGWEPF
..... .| | .   ..|||  .. ..    .|   .. .......                                             | |. |. .
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhlpwpDh

GVPIRYANTTRsVVDVMNFVkSSNGSEKLLVVSKNGCGRAGFFITLGAAFcclndnSEPRIGEIVKAIRSQRPNAVESIKQYASLY
|||         .......    . ... ||  . |.||.|... .              . |.|. .|..||.||..  |.  ||
gvpdlsqlllf.lllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 196-405 3.4e-09 30.8 In-house 68-294 (301) alignment
Range on Protein: 196-405
Range on HMM: 68-294/301.0
KPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSEDE----KYDFFPKTTGSFLYYGEMFVNVRKVEKMDEERS--------
.  .|.| | .     .    . | | .    .|||  ..|..| . .. . ...     . ..|... .  ..|.. | . .   . .           
cqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiq

-----RYTIEVLPNGFS-NSVMMNVYVHTGWEPFGVpIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVK
      |..  .    . .|  .  .  | |   || .|  .|   |.| .   . . |  ...|   .. .|.| ....  .      .    . ...|
dgsnngyierkfkvksdksswdvlqlqvtdWpqdGv.vreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtk

AIRSQRPNAVESIKQYASLYLCLLYYIK
|.| ..| ||  ..|| |.|  .  |..
avrrskpgaVtTLeqytsiydvidmylq

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 172-407 1.3e-08 28.9 In-house 53-292 (305) alignment
Range on Protein: 172-407
Range on HMM: 53-292/305.0
KKNLAKNQTDVYPILDATLVK--DPAkPDSYVNMSSVIVPHCS-YPILMGQIPKRGLEEEFWRAA---YNEQVVMMYVLVGSEDEKY-DFFPKTTGSFL-
. . .||. .  |  | ..||  .|. |  |.    | .|      ..  | |     .|||        ||.||.   |     |  ...| . |  | 
diaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

-YYGEMFVNVRKVEKMDEErSRYTIEVLPNGFSNSVMMNVY--VHTGWEPFGVPIryanTTRSVVDVMNFVKSSNGseKLLVVSKNGCGRAGFFITLGAA
   | .  ||     |. . .   | .|   .| .  | |     | |   |||        . ....  .. |.    ..|    | ||.|  ...   
lksgivvenvsgskpmerd.aeiqitllnltysgdqkmsvrhlqwtewpdrgvpp....ckltslellsairgskv..pivvhcsagigrtgtivaieyi

FCCLNDNSE-PRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKK
.  . .| . | . |.|||.| ||  ....  ||  ..  .| |. .|
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 176-405 1.3e-08 28.9 In-house 40-278 (287) alignment
Range on Protein: 176-405
Range on HMM: 40-278/287.0
AKN-QTDVYPILDA--TLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVL---VGSEDEK-YDFFPKTTGSFLYYGEM
 ||  .|| || |.   |.... .  .|.|   |   .     .  | |      .|||| .....  . ..   |     | | ..|.     .  |  
kknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGys

FVNVrKVEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDV---MNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLN
 | . . .... | .  .. ..     .. ... .    |   ...       | |.||   ..  .....   |.|  . | ||.| .... .    |.
vvll.dydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrle

DNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
|  .  .  .|  .| .|   | .. |.  ||  |  | |
dlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

0044763 (Phosphotyrosine protein) phosphatases II 205-406 5.3e-08 28.2 In-house 24-173 (178) alignment
Range on Protein: 205-406
Range on HMM: 24-173/178.0
SVIVPHcsyPILMGQIPkrgleEEFWRAAYNEQVVMmYVLVGSEDEK-----YDFFPKTTGsflyygemfvnvrkvekmdeersrytievlpngfsnsvm
| |.|.    .|... |     .....  ... . .  | . .|.|      .  .|. .|                                       
seilpg...lylgslpp.....addlellkelgith.ivnlteelelgflkcdpywpeeag.......................................

mNVYVHTGWEPFGVPIrYANTTRSVVDVMNFVKSSNGsEKLLVVSKNGCGRAGFFItlgAAFC---ClndnsEPRIGEIVKAIRSQRPnAVESIKQYASL
   |.|.... .|||      .. .|. .. . ...| .. ||  . | ||.| ..   ||.    .        . |... .|..|| .|..  |.  |
.iqylhipipDhgvpd.llehflefvefieealdekg.gpvlVHCsaGvgRsgtlv...aaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqL

YLCLLYYIKK
|.. |.. |.
yefelrllke

subfamily_PTPN1_pd Subfamily PTPN1 174-417 7.1e-08 26.5 In-house 32-283 (290) alignment
Range on Protein: 174-417
Range on HMM: 32-283/290.0
NLAKN-QTDVYPIlDATLVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEK-YDFFPKTTG-SFLYYGE
| ..|   || |  | . .|   .   |.| | | ...     .. | |     . ||.  ....   |||.  .|  |  | ....|.    . | . .
nrnlnryrdvspy.dhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellled

MFVNVRKVEKmdEERSRYTIEVL--PN-GFSNSVMMNVYVHTGWEPFGVPIRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCL
. ..|. ...  |..| ||...|   |    ..  .  . .| |  ||||   |.  . . .| .    |.     ..    | ||.| |. . . .  .
tklkvklise..erksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvli

NDNSE---PRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKkKITVPEGLQQK
... .     | . . ..|..|   .   .|    || .|  .| .|. .  .|..
ekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak.vikgdssvqkr

subfamily_egg_pd Subfamily egg 216-414 7.6e-08 26.4 In-house 86-280 (307) alignment
Range on Protein: 216-414
Range on HMM: 86-280/307.0
LMGQIPKRGLEEEFWRAAYNEQVVMMYVLVG---SEDEKYdFFPKTTGSFLYY--GEMFVNVRKVEKMDEERSRYTIEVLpNGFSnsvMMNVYVhtgwEP
.. | | .   ..|||  ..|.|  . .|     ||  .| ..||.    | .  | . ..  ||..  .   | |   |  |       . ..    | 
ilaqaplkntvddfwrmvfqeevqyivmltsrkesercey.ywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgd...deerfl....eh

FGVPIRYANTTRSVVDVMNFVKssNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDN--SEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKI
.   .....   | . |.  ..  | |.  .| ...|. .|. ....  |.. |         . . |. .| .|. .|||. .|  .|  .|....  |
wqgdvnnssdvysplrvlrklr..nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi

TVPEGL
   . |
gsakel

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 177-417 2.1e-07 25.0 In-house 51-300 (305) alignment
Range on Protein: 177-417
Range on HMM: 51-300/305.0
KNQTDVYPILDATLVK-DPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVLVGSED----EKYDFFPKTTGSFLYYGEMF--
||.      ||   || ... |  |.    |  |  .  ..  | |      .||   ....| ....|    .      ...|.   .  | . |    
knrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqk

--VNVRKVEKM---DEERS--RYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNGSekLLVVSKNGCGRAGFFITLGAAFC
  | .   ...   .. ..  . |. |.    ...  .. |    |   |||     .  .......  ..| |   . |    | ||.|  . |   . 
isvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvp....aadlailellekarpskgp..ivvhcsagigrtgsvvmleyild

-CLNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKKKITVPEGLQQK
  |. .       |.. || || |.... .||  ..  .| |..||  . |  .. 
qllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkea

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 220-410 2.4e-07 24.5 In-house 98-294 (302) alignment
Range on Protein: 220-410
Range on HMM: 98-294/302.0
IPKRGLEEEFWRAA--YNEQVVM-MYVLVGSEDEKY-DFFPKTTGSFLYYGEMFVNVRKVEKM-DE-----ERSRYTIEVLPNGFSNSVM--MNVYVHTG
.||.   | .|     ||  .|. .  .| .|..|. ... .  |  | .|.  |.  .|..  .|     .   ||.|.  .   . |   ... ....
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WEPFGVPiryaNTTRSVVDVMNFVKSSNgsEKLLVVSKNGCGRAGFFIT--LGAAFCCLNDNSEprIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
|   | |    . . . .|...| .|    ...||   .| ||.| ...   |  .|  .. ..  . .||. .|. |  || . .|   | ||.   . 
wpdhGap....keaytaldilkfcesyk..knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtd..llsivlpvrqcryGavqdeqqliylllcvtkglm

KKITV
.|..|
ekagv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 292-401 2.6e-07 24.4 In-house 84-191 (440) alignment
Range on Protein: 292-401
Range on HMM: 84-191/440.0
NGFsNSVMMNVYVHTGWEPFGVPiRYANTTRSVVDVMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDNSEPRIGEIVKAIRSQRPNAVESIK
||  .|  .. | . ||   ||| ..|     ... .|  .   |.  ||| .  |.||.|  |.. . .   . . .  |  .....|..||. |.. .
ngi.esrtlkqyhyqgwpdkgvp.kfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QYASLYLCLL
||| .. ..|
qyafvheavl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 167-403 4.4e-07 23.8 In-house 28-268 (281) alignment
Range on Protein: 167-403
Range on HMM: 28-268/281.0
NCTVWKK--NLAKNQTDVYPILDATLV----KDPAKP-DSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQ---VVMMYVLVGSEDEKY-DFF
 |||...  |  ||.    | || . |    | | |    |.    .  |      .. | ||.    .|||  ..|.   .||.  .. .. ||  ..|
lctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyf

PKTTGSFLYYGEMFVNVrkvEKMDEERSRYTIEVLPNGFSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSsnGSEKLLVVSKNGCGRAGFFI
|. .   | . .. |.    |    ..|  |  .      .. ..  ..   |  . ||    ...  .. ..  ...   |   ..    | ||.| ..
prnahcclqfdklsvsy...edstvnkslvttrlnlsyegetrlithwlwkewpdwqvp....essevmlkilrkira..rstppvihcsagvgrsgtlm

TLGAAFCCLND-NSEPRIGEIVKAIRS-QRPNAVESIKQYASLYLCLLYY
..  |.  .    . | | .||  .|   |  .|....||  ..  || .
aveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 198-401 5.5e-07 24.0 In-house 46-257 (290) alignment
Range on Protein: 198-401
Range on HMM: 46-257/290.0
DSYVNMSSVIVPHCSYPILMgQIPKR-------GLEEEFWRAAYNE---QVVMMYVLVGSEDEKYD-----FFPKTTGSFLYYGEMFVNVRKVEKMDEER
| |.  . |..|.    ||. | |.           |.|| .| .|   ||||.      . .. .     ..|.. |  | .. . |.  . || |.  
ddyiHAnrvtcpnglrlilt.qsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

SRyTIEVLPNGfSNSVMMNVYVHTGWEPFGVPiryaNTTRSVVDVMNFVKSSNGseKLLVVSKNGCGRAGFFITLGAAFCCLN-DNSEPRIGEIVKAIRS
 | ...|  ..  .   .. .   ||..  |.    ..|.........|| |.     .|  ..|  |   . ..  ..  .   ...  . ...||.|.
tR.elvvkfdd.eeeftvtHsllkgWnklnvq....edtktllsliqkvkaskt..pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

QRPNAVESIKQYASLYLC-LL
|| .|. | ...|      .|
qralaitsalelafvdagivl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 167-405 1.1e-06 23.0 In-house 34-278 (307) alignment
Range on Protein: 167-405
Range on HMM: 34-278/307.0
NCTVWKKNLAKNQTDVYPILDAT--LVKDPAKPDSYVNMSSVIVPHCSYPILMGQIPKRGLEEEFWRAAYNEQVVMMYVL---VGSEDE-KYDFFPKTTG
.   .. |  ||. .  .  | .  .|| .     |.    . .      ..  | |.     .||  | .|.|  . .|   .        ...|   |
tveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleeg

SFLYYGEM----FVNVRKVEKMDEERSRYTIEVLPNGFS-NSVMMNVYVHTGWEPFGVPiryaNTTrsvVDVMNFVKSSNGSEK-LLVVSKNGCGRAGFF
  | .||      |.   ..|.  .     .  |   .. .|  .. .  . |   |||    ..    .  .|.... .. .  ..|    | ||.|  
qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvp....qin...ltainlleavrydtnpvvvhcsaGvGrsGti

ITLGAAFCC-LNDNSEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIK
...       ..      . ..|. .||||. |...  ||  |.  || |  
vaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 200-403 1.4e-06 22.4 In-house 61-294 (297) alignment
Range on Protein: 200-403
Range on HMM: 61-294/297.0
YVNMSSVIVPHCSYPI--LMGQIPKRGLEEEFWRAAYNEQVVMM---YVL-VGSEDEKYDFFPKTTGSFLYYGEMFVNVrkVEKMDEERSRYTIEVLPNG
|.|   |. |.   ..  .. | | .   ..||.  ....| ..     |  .  |  . ..|.. .  |  |.. |.   . .. .|  |  .  |   
yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvvef..lsstsdefdrviltelqli

F-SNSVMMNVYVHTGWEPFGVP------IRY-A---------NTTRSVVD---------VMNFVKSSNGSEKLLVVSKNGCGRAGFFITLGAAFCCLNDN
. |.| ...   . .|   |||       |. |             ..|.         .  .      .  |||    | ||.|  .   .    |  .
yrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkk

SEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYY
  | .  |.. .|.||.  |....|.  ||   |  
ripdvaailsilreqrarlvqtleqfellydavlkk

subfamily_CG42327_pd Subfamily CG42327 339-406 6.4e-06 20.0 In-house 249-317 (319) alignment
Range on Protein: 339-406
Range on HMM: 249-317/319.0
KLLVVSKNGCGRAGFFITLGAAFCCLNDN-SEPRIGEIVKAIRSQRPNAVESIKQYASLYLCLLYYIKK
 | |   .| ||.|  |.   |.  |...     | ..|  .| .| .|| ...||. .|  |  | ||
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk