Gene Y69A2AR.19 in Caenorhabditis elegans

Synonym: CELE_Y69A2AR.19, CELE_Y69A2AR.19

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf19
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP226_AA protein Get Run
CeleP226_AA_1003-1255 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 973-1272 1e-141 466.1 In-house 5-300 (301) alignment
Range on Protein: 973-1272
Range on HMM: 5-300/301.0
EIVVWVKAQAYKSLEAAIIVLVASLHVVWGTQTS-VSVEKSNAYLPKEKNRRPLAtPCNPETAVEVMSDGTRIPIHANWINTSpdvdGNTQKFIATQGPL
.| .|.... .|  . .     .... |  |  .   ...|.|||||.|.|.| . ||.|.|||||..||.|.|||||||.||    |....||||||||
kiekwiiskdfkdddktakfynttienvnvttidkdhitesyaylpkdkhryptv.PckPstavevivdGkrvPihanwipts....GhphrfiatqgPl

PNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQILGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQG
.|||.|||.|.....||..|||.|.|||.||||.||.||.... .|..|.|.|....|.|| ...||||..|||....|.|||.|||||..|.|.|.|..
kntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPks

HAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVYRLSKEKNIDMKHYKEQFEML
||..||||...|.|.|||||||||||||.|.||.|.|....|.|..|..|..|...||..||...||..|.||...|.||||.||...|||.|.||..|.
haelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlikeygfdmkiyeeqlamf

D
|
d

0036941 (Phosphotyrosine protein) phosphatases II 1017-1269 2.7e-66 219.2 In-house 39-292 (297) alignment
Range on Protein: 1017-1269
Range on HMM: 39-292/297.0
PKEKNRRPLaTPCNPETAVEVmSDGTRIPIHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIV
 .|||| .   .... | | . .|.    |.|...    |. . ..|||||||||||| .||| ||  ..|...|||...||.. |||..|.|  .|. .
nleknRykd.ilpydhtRVkl.ddegsdYinAsyv....dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesl

DLERYKLKTVTQEQILGDSTSKRTIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE------SKKPIVVHCSAGIGRTVSFIATQYIP
  ......... |..| |.   ||..|.|| .. ..||.||..|..||| |.|. .|...|.......      |..|..||||||.||. .|||  .. 
tygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlml

SAVL---ANRTLVLNQAVAELRDQRWCAIQTVEQMYWVqVGSVYRLSKEKNIDMKHYKEQFE
. .     .... . .|| .||.||..|.||.||....    .. | | |.... ..|. ..
qqledklkeggvdileavkklReqRpgavqtleqyrfl.yeallellkkkltkepllklvll

0040438 (Phosphotyrosine protein) phosphatases II 1008-1248 9.1e-65 214.3 In-house 34-271 (317) alignment
Range on Protein: 1008-1248
Range on HMM: 34-271/317.0
SVEKSNAYLPKEKNRRPLaTPCNPETAVEVMSDGTRIP---IHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKC
. . .. .  |.||| |   .... . | . ..| . .   |.|...    |.   ..|||||||||||| .||| ||. ..|...|||....|.. |||
tysvaelpenkdknrypd.ilpydhsRVkLsplggdldsdYInAsyv....dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekc

HEYFPVrtGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES----KKPIVVHCSAGIGRT
..|.|   |. .  .... ...  |.   ..   ||..|||. .. ..||.||..|..|||.|.|. . ...|......|.    ..|..||||||.|||
aqYwpl..getltygdftvtllseee..lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRt

VSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVG
 .|||  .. . .  .... . .||.||| ||..|.|| ||....   
GtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda

0050432 (Phosphotyrosine protein) phosphatases II 1004-1245 1.9e-63 210.0 In-house 55-291 (308) alignment
Range on Protein: 1004-1245
Range on HMM: 55-291/308.0
QTSVSVEKSNAYLPKEKNRRPLaTPCNPETAVEVmsDGTRIPIHANWINTSPdvDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEK
... . . ..    |.||| .   ...  . | .  |..   |.|.....     ....|||||||||||| .||| ||  ..|...|||...||.. ||
kplleysvallpenkdkNrykd.ilpydhsRVkl..degsdYInAsyvdgys..sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrek

CHEYFPVRTG-QIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES--KKPIVVHCSAGIGRT
|..|.|  .| ...  ........ .|.   |.  .||......... ..||.||..|..|||.|.|.  ....|.......|  ..|||||||||.|||
caqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRt

VSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
  |||  .. . . ..... . .||. || ||....||.||....
GtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl

0045450 (Phosphotyrosine protein) phosphatases II 1007-1246 2.2e-62 206.9 In-house 45-297 (307) alignment
Range on Protein: 1007-1246
Range on HMM: 45-297/307.0
VSVEKSNAYLPKEKNRRPLaTPCNPETAVEVMSDGTRIP----IHANWINTSP----DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVE
 . . .. .  |.||| .   .... | | ..| . ...    |.|..... .    |.  ...||||||||||.| .||| |.. ..|...|||...||
geysiallpenkdknrykd.ilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve

KEEEKCHEYFPVRtGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE------SKKPIVVH
.. |||..|.|   |. .  .... ...  |.   |.   ||. |.|.......||.||..|..|||.|.|.  ....|.......      ...|..||
lgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVH

CSAGIGRTVSFIATQYIPSAVLANRT---LVLNQAVAELRDQRWCAIQTVEQMYWVQ
||||.||| .|||  .. . . .. |   . | .||..||.||..|.|. ||.....
CsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly

0047943 (Phosphotyrosine protein) phosphatases II 1012-1245 1e-61 204.1 In-house 33-264 (273) alignment
Range on Protein: 1012-1245
Range on HMM: 33-264/273.0
SNAYLPKEKNRRPLaTPCNPETAVEVmSDGTRIPIHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVR
..    |.||| .   ...  . | . .||.   |.|...    |.   ..|||||||||||| .||| ||  ..|...|||...||.. |||. |.|  
allpenkdknrykd.ilpydhsrvkl.gdggsdyinAsyv....dgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwple

TGQ-IVDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE------SKKPIVVHCSAGIGRTVSFI
 |.  .  .... ... .|.   |.  .||....... .  .||.||..|..|||.|.|.  ............      |..|.|||||||.||| .||
ggelsltygkftvtllseet..kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfi

ATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
|  .. . . ..... . .||. ||.||....||.||....
aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl

0046845 (Phosphotyrosine protein) phosphatases II 1016-1245 3.1e-60 199.3 In-house 27-266 (284) alignment
Range on Protein: 1016-1245
Range on HMM: 27-266/284.0
LPKEKNRRPLaTPCNPETAVEVMSDGT----RIPIHANWINTS-PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPV
  ..||| .   ...  . | . | .        |.|.....   |.  ...|||||||||||| .||| ||  ..|...|||...||.. |||. |.| 
enlsknRykd.ilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwpl

RtGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES------KKPIVVHCSAGIGRTVSFI
  |. . ..... ...  |.   |.  .||....... . ..||.||..|.||||.|.|.  .. ........|.      ..|||||||||.|||  ||
e.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfi

ATQYIPSAVLANR---TLVLNQAVAELRDQRWCAIQTVEQMYWV
|  .. . . ...   .. . .||. ||.||....||.||...|
aldllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv

0051299 (Phosphotyrosine protein) phosphatases II 1010-1245 1e-59 197.8 In-house 42-278 (288) alignment
Range on Protein: 1010-1245
Range on HMM: 42-278/288.0
EKSNAYLPKEKNRRpLATPCNPETAVEVMSDGT---RIPIHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHE
  ..    .||||     ...  . | . . .       |.|..|    |.  ...|||||||||||| .||| ||  ..|...|||...||.. |||. 
saallpenleknRy.sdilpydhsRVkLsvldgvegsdYinAsyi....dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaq

YFPVrtGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTS---KEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES----KKPIVVHCSAGIGR
|.|   |. . ..... ...  |.   |.  .||..|....   ..  .||.||..|..|||.|.|.   ...|........    ..|.|||||||.||
Ywpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgR

TVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
|  |||  .. . ....... . .||. || ||....||.||...|
tgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv

DSPc_SM00195 1008-1243 1.3e-58 193.8 In-house 17-252 (263) alignment
Range on Protein: 1008-1243
Range on HMM: 17-252/263.0
SVEKSNAYLPKEKNRRPlATPCNPETAVEVMSDG---TRIPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKC
......    |.|||     ... .| |.. ..    .   |.||.|...     ...|.||||||||.| .|||.||  .||...|||....|...|||
etteaekkknksknRyk.nilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

HEYFPVRTGQIVDLERYKLKTVTQEQILgDSTSKRTIQVEDTSKeFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKK----PIVVHCSAGIGRT
..|.|   |.  . .....|.| .|.   |.. .||.... . |   ||..|.|||..|||.|.|. . ....|....|.||.    |||||||||.|||
drywpeesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRt

VSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMY
 .|.....| | . .. .. . . | |||.||  ..|| ||  
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYl

PTPc_SM00194 1008-1243 1.3e-58 193.8 In-house 17-252 (263) alignment
Range on Protein: 1008-1243
Range on HMM: 17-252/263.0
SVEKSNAYLPKEKNRRPlATPCNPETAVEVMSDG---TRIPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKC
......    |.|||     ... .| |.. ..    .   |.||.|...     ...|.||||||||.| .|||.||  .||...|||....|...|||
etteaekkknksknRyk.nilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

HEYFPVRTGQIVDLERYKLKTVTQEQILgDSTSKRTIQVEDTSKeFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKK----PIVVHCSAGIGRT
..|.|   |.  . .....|.| .|.   |.. .||.... . |   ||..|.|||..|||.|.|. . ....|....|.||.    |||||||||.|||
drywpeesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRt

VSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMY
 .|.....| | . .. .. . . | |||.||  ..|| ||  
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYl

0039614 (Phosphotyrosine protein) phosphatases II 1009-1246 3.8e-58 192.6 In-house 48-282 (297) alignment
Range on Protein: 1009-1246
Range on HMM: 48-282/297.0
VEKSNAYLPKEKNRRPLaTPCNPETAVEVMS-DGT---RIPIHANWIntspDVDGN-TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEeK
 . .. .  |.||| .   .... . | . . ||.      |.|...    |.    |.||||||||||.| .||| ||. ..|...|||...||..  |
ysiallpenkdknrykd.ilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.k

CHEYFPVRTGqivDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEfptRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE------SKKPIVVHCSAGI
|..|.| ..|     .... .... |.   |    ||. |......   ||.||.||..||| |.|. ............|      ...|..||||||.
caqywpeegg...tygdftvtllkveh..ldgytvrtlevtnnges...rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGv

GRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
||| .|||  .. . .  .... . .||.||| ||..|.|| .|.....
gRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfly

0043336 (Phosphotyrosine protein) phosphatases II 1009-1245 2.8e-57 189.7 In-house 37-269 (278) alignment
Range on Protein: 1009-1245
Range on HMM: 37-269/278.0
VEKSNAYLPKEKNRRPLaTPCNPETAVEVMSDGTRIP---IHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCH
 . .. .  |.||| .   .... . | . ..| . .   |.|...    |.   ..||||||||||.| .||| ||. ..|.|.|||...||.. .||.
ysiallpenkdknrykd.ilpydhsrvklsllggdldsdYinAsyv....dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkca

EYFPvrtGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFPtRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE----SKKPIVVHCSAGIGRTV
.|.|   |. .  .... ... .|.   |    ||. |... . .. ||.|||.|..|||.|.|   .. .|......|    |..|..||||||.||| 
qYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTG

SFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
 |||  .. . .  .... | .||.||| ||..|.|| .|....
tfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl

Y_phosphatase Protein-tyrosine phosphatase 1019-1245 7.6e-57 187.8 Pfam-A 3-229 (235) alignment
Range on Protein: 1019-1245
Range on HMM: 3-229/235.0
EKNRRPlATPCNPETAVEV-MSDGTRIPIHANWINTSPDvdgnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVD
.||| .   ..  .| |..  |.|.   |.||.... ..    ..|||||||||..| .||| ||  .||...|||.. .||..|||..|.| .... . 
kknRyk.dilpydktrvklkgsegpsdYInAnyvkgyke....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

LERYKLKTVTQEQILGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK----KPIVVHCSAGIGRTVSFIATQYIPSAV
 ...|......|.   ...  |....... .|  .|......|..|||.|.|.   . .||... ..||    .|.|||||||.||| .|.| ... . .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

LANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
 |.... . |.| ||| ||  ..|..|| ...
eaeeevdvlqivkelRkqRpgmvqsleqYifl

Y_phosphatase Protein-tyrosine phosphatase 1019-1245 7.6e-57 187.8 In-house 3-229 (235) alignment
Range on Protein: 1019-1245
Range on HMM: 3-229/235.0
EKNRRPlATPCNPETAVEV-MSDGTRIPIHANWINTSPDvdgnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVD
.||| .   ..  .| |..  |.|.   |.||.... ..    ..|||||||||..| .||| ||  .||...|||.. .||..|||..|.| .... . 
kknRyk.dilpydktrvklkgsegpsdYInAnyvkgyke....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

LERYKLKTVTQEQILGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK----KPIVVHCSAGIGRTVSFIATQYIPSAV
 ...|......|.   ...  |....... .|  .|......|..|||.|.|.   . .||... ..||    .|.|||||||.||| .|.| ... . .
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

LANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
 |.... . |.| ||| ||  ..|..|| ...
eaeeevdvlqivkelRkqRpgmvqsleqYifl

0040439 (Phosphotyrosine protein) phosphatases II 1015-1246 3.1e-56 186.1 In-house 9-239 (249) alignment
Range on Protein: 1015-1246
Range on HMM: 9-239/249.0
YLPKEKNRRPLaTPCNPETAVEVMSDGTRIP---IHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVr
.  |.||| |   .... . | . . . . .   |.|..|    |.   ...|||||||||.| .||| |.. ......|||...||.. |||..|.|  
penkdknrypd.ilpydhsrvklsilpglflsdyinAsyi....dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

tGQIVDLERYKLKTVTQEQilGDSTSKRTIQVEDTsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE------SKKPIVVHCSAGIGRTVSFIA
 |. .  .... ...  |.   |.   ||...... .. ..||..|.||..|||.|.|.  ....|.......      ...|..||||||.|||  |||
.ggsleygdftvtllsvev..kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

TQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
  .. . .  .... | .||..||.||..|.|. ||.....
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfly

0042113 (Phosphotyrosine protein) phosphatases II 1018-1246 8.9e-56 184.4 In-house 10-236 (245) alignment
Range on Protein: 1018-1246
Range on HMM: 10-236/245.0
KEKNRRPlATPCNPETAVEVMSDGTRI---PIHANWIntspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVrtGQ
|.||| .   .... | | ...||..    .|.|...    |..  |.||||||||||.| .||| |.. ....|.|||....|.. .||..|.|   |.
kdknrys.dilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

IVDLERYKLKTVTQEQilGDSTSKRTIQVEDTsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE-----SKKPIVVHCSAGIGRTVSFIATQYI
..  .... .... |.   |.   ||..|... .....|...||.|..|||.|.|  ... .|.......     |..|..||||||.|||  |||  ..
sltygdftvtllseeh..lddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

PSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
 . . ..... | .||.|||.||..|.|| .|.....
leqlekelgvsleeavkelrsqRpgavqtpsqyrfly

0045098 (Phosphotyrosine protein) phosphatases II 1015-1245 2.2e-54 180.1 In-house 30-264 (278) alignment
Range on Protein: 1015-1245
Range on HMM: 30-264/278.0
YLPKEKNRRPLATPCNPETAVEvmsDgtriPIHANWINTSpdvdgNtQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPvRtGQ
||   .  |    .... . |    |     |.|..|..      . .||||||||||.| .||| |.. ......|||...||.. |||..|.|   |.
ylgnldknRykdilpydhsrVk...d....YINAsyidgy.....p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e.gg

IVDLERYKLKTVTQEQIlgDSTSKRTIQVEDT---SKEFPTRTITHYQYHSWPDQGIPQGH--AQCFDLMNMAKE-----------------SKKPIVVH
 .  ........  |..  |   .||. |...    .....|..||..|..||| |.|  .  .. ..|... .|                 |..|..||
sltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CSAGIGRTVSFIATQYIPSAVlaNRTLVLNQAVAELRDQRWC-AIQTVEQMYWV
||||.|||  ..|  .. . .  .... | .||.||| ||.. |.|. ||....
CsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrfl

0037934 (Phosphotyrosine protein) phosphatases II 1018-1246 8.5e-51 168.2 In-house 11-235 (243) alignment
Range on Protein: 1018-1246
Range on HMM: 11-235/243.0
KEKNRRPLaTPCNPETAVEVmsDGtRIPIHANWINTSPdvdgntqKFIATQGPLPNTSDD----FWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPvrtG
..||| .   .... . | .  .|    |.||.|.  |       ..||||||||.| .|    || |.. ......|||...||.. |||..|.|   |
lsknrysd.ilpydhsrvkl..eg.sdyinanliyvtp.......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...g

QIvDLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAK------------ESKKPIVVHCSAGIGRTV
..   .... ... .|.  .|.   ||...| .. . .||...||.|..|||.|.|. .... |......             |..|..||||||.||| 
ev.tygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

SFIATQYIPSAVlanrTLVLNQAVAELRDQRWC-AIQTVEQMYWVQ
 .||  .. . .    .. | .||..||.||.. |.|| .|.....
tliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrfly

subfamily_PTPRD_pd Subfamily PTPRD 1047-1271 7.1e-47 155.3 In-house 80-300 (564) alignment
Range on Protein: 1047-1271
Range on HMM: 80-300/564.0
HANWINTSPdvdgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRtGqIVDLERYKLKTVTQEQiLgDSTSKRTIQVeDT
 |..|..      . ...|||||||..| .||| ||  ....|.||| . .||...|||.|.| . |     .... . . .|. |    . ||...  .
NAsfidgyr....krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeee.l.adyeirtfkl.kk

SKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAK----ESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQM
.|.  .|....... ||||.|.|.  ..  ||..  .    . ..|||||||||.|||  ||. ...   . ...|. . | |..|| ||   .|| || 
kkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQY

YWV-QVGSVYRLSKEKNIDMKHYKEQFEML
 .. ..   .  . .........|.....|
iFiheailealacgntevesenlkqhlqkL

subfamily_PTPN12_pd Subfamily PTPN12 1047-1246 9.4e-46 151.0 In-house 72-270 (290) alignment
Range on Protein: 1047-1246
Range on HMM: 72-270/290.0
HANWINTspdVdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTqEQILGDSTSKRTIQVEDT
 ||.|.    |  .....||.|||||.| |||| |.. ..|| |||.|. || .  ||. |.| .... .  . ..... . |. . |    ||..||  
nanfikg...v.egkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtlee.ekavdddflirtLkveaq

SKefpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE----SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRT---LVLNQAVAELRDQRWCAIQTV
..   .|... ..|..|||.|.|... . ..|.....|    ...|.|||||||.|||   || .|. ... |...   | . . |.||| || ...|| 
ke...srkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtk

EQMYWVQ
||   | 
eqyelvy

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 980-1258 2.1e-45 150.1 In-house 5-283 (307) alignment
Range on Protein: 980-1258
Range on HMM: 5-283/307.0
AQAYKSLEAAIIVLVASLHVVWGTQTS-VSVEKSNAYlpKEKNRRpLATPCNPETAVEVMSDGTRI-PIHANWINTSpdvdGNTQKFIATQGPLPNTSDD
    ..|.  .  ||  ..|.   .   |.||  .|    .|||     .|   . . |  ||     ||||.. ..     . .|||..|||| ||  .
pwvqrtldkgvqalvdefrvlakktpegvtveafsan..tdknry.qdvkcqdkgrivvkfdglasdyihanylgia....ikpkkficaqgplentqys

FWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDL-ERYKLKTVTQEQILGDSTSKRTIQVEDTSKEF--PTRTITHYQYHSWPDQGIPQGHAQ
||.|.  .|||.|.|||. .|  . ||..|.|.  ||     |. .  .|..  .   .  .  |.| .   ..   .|||.|.|.. |||.|.||    
fwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinlt

CFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANR-TLVLNQAVAELRDQRWCAIQTVEQ-MYWVQVGSVYRLSKEKN
. .|..  .  . |.|||||||.||. . .|  ..   ..|      ... | |||.||  ||||  | .|  .|   | | . |.
ainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyke

subfamily_PTPN13_pd Subfamily PTPN13 1017-1247 3.6e-45 149.4 In-house 37-263 (273) alignment
Range on Protein: 1017-1247
Range on HMM: 37-263/273.0
PKEKNRRPLATPCNpETAVEVMSDGTriPIHANWINTSpdVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIV
 |.|||     |.. || |.. ..|.   | |..|.    |. .. ..||.|||||.| .||| ||   |.| ..|. . .||.. ||| |.|..... .
nkdknryrnvlPyd.etrvklgdegg..yinaslikvp..vgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

DLE-RYKLKTVTQEQIlgDSTSKRTIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMN---MAKESKKPIVVHCSAGIGRTVSFIATQYIPSA
 .. |.... . ...   |. . |...|.|.  .  .| ..| .. .||| |.|.  |.   ..      .... ||||||||||||. ..|. . .   
kvsnrlevellkvqkl..dgfvvralavkdsesg.esrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlgl

VLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQV
.  .. . ... | .||.||   .|| .|  .|  
ierdkefdvkeivrklreqrqgvvqtkdqyifvyk

subfamily_PTPRB_pd Subfamily PTPRB 1046-1247 5.6e-45 148.6 In-house 82-279 (293) alignment
Range on Protein: 1046-1247
Range on HMM: 82-279/293.0
IHANWINTspdVdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIvDLERYKLKTVTQEQIlgDSTSKRTIQVED
| ||.|.        ...|||||||||.| |||| ||  .|....||| | |||  .||.||.|  . ..      |.. |..|.   .    |....| 
inanyipg...y.nsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeel..edwvirelkiek

tskEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK------KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTV
   |  .|....|.. |||| |.|.  ..  |.... .|..      .|||||||||.|||  ||| . . .|.  . .. .   ||||| .| . .||.
...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqte

EQMYWVQV
.|  ... 
kqYifihq

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1008-1245 1.3e-44 147.4 In-house 38-271 (288) alignment
Range on Protein: 1008-1245
Range on HMM: 38-271/288.0
SVEKSNAYLPKEKNRRPLATPCNpETAVEVMSdGTRIpIHANWINTS-PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHE
||....    ..||| .   | . |..|..   .      |..|| |  |......|.|||||||..| .||| .|  .|..|.||| ..||....||.|
svtagrlavnakknRyrnilpyD.ekrvklkk.leee.agaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCee

YFPVRTgQIVDLERYKLKTVTQEQIlgDSTSKRTIQVEdtsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNM---AKESK-KPIVVHCSAGIGRTVS
|.|    . .     ... | ...   ... .|.. .|   |.   ..||.||| .|||.|.|. .|. ..|...   |.... .||.||||||.|||  
YWPdad.kpknyGsvtvtlveskel..edfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgt

FIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
||| . .  || .. .. .  .||.|| ||   .||..|  ..
FialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefi

subfamily_PTPN3_pd Subfamily PTPN3 1019-1255 4.9e-44 145.3 In-house 43-276 (280) alignment
Range on Protein: 1019-1255
Range on HMM: 43-276/280.0
EKNRRPLATPCNpETAVEVMSDGTrIPIHANWINTSPDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVrTGQIVDL
.|||    .| . .| |.. .  |   | ||..|   .  |  ...|||||||..|. |||.||. .|....||| . ||.   |||.|.|  |.. ...
sknryrdilpyd.atrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeley

ERYKLKTVTQEQilGDSTSKRTIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK----KPIVVHCSAGIGRTVSFIATQYIPSAVL
 ....|   ...    |   | . ..|....   |.|.. || .|||.|.|. .|. .....  .. .    .|.|||||||||||  .|. .   . . 
gefsvkcekede..tksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalie

ANRTLVLNQAVAELRDQRWCAIQTVEQMYWVqVGSVYRLSK
|.. .   . | ..|||| . .||..|  .|   .. ....
aaepvypldivrtmrdqramlvqtasqykfv.Ceailkvye

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1030-1246 8.9e-43 141.2 In-house 32-257 (270) alignment
Range on Protein: 1030-1246
Range on HMM: 32-257/270.0
NPETAV---EVMSDGTRIPIHANWINtspDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTV
.|.| |   |. .| .   | ||...    .||...|.||..||||.|  .|| |.  .||...||. ...||  .||  |.| .... |.||  |.|..
sPatRvrleeleedsataYinAnyvr...GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvl

TQEQILGDSTSKRTIQVEDTSKefpTRTITHYQYHSWPDQGIPQGHA---QCFDLMNMAKES-------K--KPIVVHCSAGIGRTVSFIATQYIPSAVL
....   .   .. ...|....   .| ..|..|..|||.|.|. .    .  .|..| ..        .  .|..||||||.|||  .||. ..  .. 
alseekeegyiltrlrleekge...errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLe

ANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
 .. . ... ..||| .|   .|..||. ...
etkkvdvlaiieelRkdRmalvqhpeqyefly

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1045-1260 9.5e-42 137.8 In-house 75-294 (305) alignment
Range on Protein: 1045-1260
Range on HMM: 75-294/305.0
PIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKT-VTQE---QILGDSTSKRT
 ||||.. |      |...|| || || .|  ||| |   .|||.. |||...||  .||.|||. . ......|    |  |  |   ..   . .| .
yihanyvstp....tnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakak

-----IQVEDTSKEfpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVL-NQAVAELRDQRWC
     . .| . ..  .| .||| .  |||.|.|      ..|.. |. || ||||||||||||| | .  .||   .|| . .   .. .  .|.||  
vtetvlviegpgek..arkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnn

AIQTVEQMYWVQVGSVYRLSKEKNID
.||| .|  .|    .  . |.| .|
siqtdaqylfvhqvilnyfrkkklld

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1005-1245 2.9e-41 136.6 In-house 36-275 (319) alignment
Range on Protein: 1005-1245
Range on HMM: 36-275/319.0
TSVSVEKSNAYLPKEKNRRPLATPCNpETAVEVMS-DGTR--IPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEE
.........    |.||| .   ...  | | ... ||.     | |..|..      . .||||||.|| || .||| ||  ... .||||.. ||| .
vndtfdsaskeenkkknryqnilayd.rtrvvlseldgvegsdyinasfidgy....qerekfiatqaPlentiedfWrmvWeeessivvmltklveklk

EKCHEYFPVRtgQIVDLERYKLKTVTQEQIlgDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE-----SKKPIVVHCSAG
 |...|.|    ....  |. ..   .|.   .   .| ....  | |  ||...|.|| .|||...|.   .  ||..  ..     ...|||||||||
vklkkywpee..nfeeyGrlivtleeeeel..edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaG

IGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
.||| .||. . .   |  . .| . . | .|| || . .|. ||  ..
vGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfi

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1046-1246 4.1e-41 135.9 In-house 72-269 (281) alignment
Range on Protein: 1046-1246
Range on HMM: 72-269/281.0
IHANWINTspdVDGnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPvRTGQIVDLERYKLKTVTQEQIlgDSTSKRTIQVed
| ||....   ..|  ...||||||.|.. ..|| ||  .||...||. . .|..  ||| |.|    . . .  ...|....|.    .  .|....  
inanfvpg...ykg.ekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeek..atyierkfkl..

TSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMA-----KESKKPIVVHCSAGIGRTVSFIATQYIPSAVLAN-RTLVLNQAVAELRDQRWCAIQTV
. .. .||.... .| .|||.|.|.  .. ..  .       |..| |.|.|||||.||| ..||   . .|| |. ..| ... ||||| .|   .|||
eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtv

EQMYWVQ
 |  .| 
vqyefvy

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1019-1245 4.2e-41 135.8 In-house 30-260 (274) alignment
Range on Protein: 1019-1245
Range on HMM: 30-260/274.0
EKNRRPLATPcNPETAVEVMSDG----TRIPIHANWINTspdVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQ
.|||     | |... | . |.         | ||.|      |.... ..||||||||| .||| |.  ..|. .||| .. |..|.||..||| ... 
tknryktilP.nensrvllesessededssyinanyikG...ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

IVDlERYKLKTVTQ-EQILGDSTSKRTIQVEDTSKefpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK-------KPIVVHCSAGIGRTVSFIAT
 .. |||.   ..  . .  .  | |.. .. ...   .|...|| | .|||.  |.   . .||..  .||.        |.|||||||||||  |||.
eis.erygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiai

QYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
.     . .. .. . . |..|| .|   .|| ||  ..
siavrqlreeivvdvlkivcnlrldrGGmvqtseqyeli

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 998-1242 2.6e-40 133.5 In-house 29-272 (305) alignment
Range on Protein: 998-1242
Range on HMM: 29-272/305.0
HVVWGTQTSVSVEKSNAYLPKEKNRRPLATPCNPetaVEVMSDGTRIpiHANWINTSPdVDG--NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQ
. .  ...|. |.|..|   |.... .   . .    . .  . .    ....|| |  |||  . .|.|..||||.|| .||| ..   ||.|.|||..
kslyeeeesidvgkkeankaknrlkeitlldddr...iiltekesld..dsdyinasy.vdgykrkkkyivaqgPlkntvadfWrliveekvstivmltk

FVEKEEEKCHEYFPVRTGQIVDLERYKLKtVTQEQILGDSTsKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLM----NMAKESKK-PIV
 || ...||. |.| .... ......... ...|.   | . .| ...   ...  .||...||  .|||.|.||  .   .|.    .  |..|. |..
lveggkdkCrqYWpesktekkefgefsve.lksektasdyi.eRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpll

VHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQM
||||||.|||  ||| .     . .  .. . . . .|| .|  ..|| .| 
VhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqY

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1016-1257 7.2e-40 131.5 In-house 54-294 (305) alignment
Range on Protein: 1016-1257
Range on HMM: 54-294/305.0
LPKEKNRRpLATPCNPETAVEVMSDGTRIPIHANWINtSPDVDgnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQI
. . |||     ||. ..|| .        ||||..   | .    ..||..|||| .| |.|| ||  .||| .||||. ||    || .|.|.  |. 
iaitknry.qdvpcqdqsavkldkpspsdyihanyvg.cpmip..ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

VDLERyklkTVTQEQILGDSTSKRT--IQVEDTSKEF---PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIP
..|       .  |.. |    .|   ||.      .    . .. | |.  |||.|.|  .   ..|.   . || ||||||||||||| . .| .|| 
lelks....givvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyil

SAVLANRTL-VLNQAVAELRDQRWCAIQTVEQMYW-VQVGSVYRLSKEK
  .  |.    . . |  |||||  .||.  |  .  .|   | | | |
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyk

subfamily_PTPRA_pd Subfamily PTPRA 1008-1264 1.4e-39 130.9 In-house 49-307 (330) alignment
Range on Protein: 1008-1264
Range on HMM: 49-307/330.0
SVEKSNAYLPKEKNRRPLATPCNPETAVEVMSDGTRipiHANWINTSPdVDGNTQ--KFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCH
..| ..    ||||| .   | . .  .  . .|.    ....||.|  .||  .  ||||.|||. .| .||| |.  .|  |.||| .. |..||||.
tlelaskeenkeknrvvnilPydfsrvilsvkeGve...esdyinasf.idGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekca

EYFPVRtGqIVDLERYKLKtVTQEQILGDST-SKRTIQ-VEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES----KKPIVVHCSAGIGR
 |.|   | .|     ... | .|..| | |  |  .| . |...| ..| .. . ..|||| |.|      ..|..  |.       |||||||||.||
qywPde.G.lvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGr

TVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV-QVGSVYRLSKEKNIDMKHY
| .||. . .   | |.| . . ..| .|| ||   .|| ||  .. .|   | |  . ..|.   
tGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvssl

subfamily_PTPN9_pd Subfamily PTPN9 1028-1245 1.5e-38 127.5 In-house 52-282 (297) alignment
Range on Protein: 1028-1245
Range on HMM: 52-282/297.0
PCNPETAVEVMS-DGT--RIPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLK
 |  || | . . |..     |.||...       . . ||||||||..|..||| ||  ..| ..||  ..||.   || .|.|  ...  .   ....
lcydetrvvlakvdedeasdyinanfvdGy....kqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvs

TVTQEQIlgDSTSKRTIQVEDTsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES-----------------KKPIVVHCSAGIGRTVSFIATQ
.| .|.   .   .|....... |.  .|..||.|. |||| |.|.  |...|......|                  . |||||||||||||  ||.  
nveveee..edykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitld

YIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
.  | .    |. . ..|  || ||  .||| || .. 
iclsrleevgtvdvvetvkllrtqrafsiqtpeqyefc

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1020-1248 1.7e-38 127.0 In-house 59-277 (290) alignment
Range on Protein: 1020-1248
Range on HMM: 59-277/290.0
KNRrPLATPCNPETAVeVMSDGTR-IPIHANWINtspdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDL
|||     .||  | | ...||     .|||...      |    || |||.| .|  |.| ||  .|| ..||||. .|.   ||..|.| . |... .
knr.ykdvvcndktrv.ilkdGydGdyvhanyvk......GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf

ERYKLkTVTQEQILGDSTSKRTIQVEDTsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRT
  . . . ..|.   . . |.|. | |  ..     . |..  ||||. ...     . .. . ..   |.||||||||||| .|.| .     .|  . 
Geitv.lcseeddkdaniikktlsvrdk.dsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGke

LVLNQAVAELRDQRWCAIQTVEQmYWVQVG
| | . |  ||. |  ..|   | | . | 
ldlldlvralrnsrlnsvqvdiq.ylalve

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1046-1245 1.8e-38 127.4 In-house 72-272 (318) alignment
Range on Protein: 1046-1245
Range on HMM: 72-272/318.0
IHANWINTSpDVDGN--TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDleryKLKTVTQEQILGDSTSKRTIQV
  ...|| .  .||.  ....||.|.|||.| .||| ||   .  ..||| | .|.  .|.| |.| .  .  .    ||.   .|..  ..   |...|
egsDyinan.yidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsyg....klvvelkeevelsdyvlrefkv

EDtSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE-----SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQT
.  ..|  .|..  |.| ||||.|.|.  |.  ||.  ...     ...|||||||||.|||  ||| . .   . |. .. . | | .||.||   .||
tr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqt

VEQMYWV
 .|  ..
edqyefi

subfamily_PTPN6_pd Subfamily PTPN6 1015-1245 1e-37 124.8 In-house 52-289 (306) alignment
Range on Protein: 1015-1245
Range on HMM: 52-289/306.0
YLPKEKNRRPLATPCnPETAVEVMSDGTRI--PIHANWINtsPDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRT
   |||||     |   .| | . ....     | || |.   .| |.....||||| |..|  ||| ||   . . .||. . ||. .|||  |.|  .
penkeknryknilPf.Dhtrvilkepsvpgsdyinanyik..kevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdee

GQIVdLERYKLKTVTQEQilGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMN---MAKES-K----KPIVVHCSAGIGRTVSFI
 .     ......|....   ..   |...|. ..|.  .|.. .|...||||.|.|.   .  |...   . .|. .     ||||||||||||| .||
ekee.yGkisvtnvseks..ladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi

ATQYIPSAVLANRTL---VLNQAVAELRDQRWCAIQTVEQMYWV
 .  . . .  . .     ....|  .|.||   .|| .|  .|
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfv

0041856 (Phosphotyrosine protein) phosphatases II 1042-1247 1.7e-37 124.1 In-house 18-165 (182) alignment
Range on Protein: 1042-1247
Range on HMM: 18-165/182.0
TRIPIHANWINTSPDVDGntqkFIATQGPLPNTSDDFWTMVQFHKVETVVMLCqfvekeeekCHEYFPvrtgqivdleryklktvtqeqilgdstskrti
    |.||..  |   .     ||||||||..|  ||..|.. ... |.|.|.         .. |.|                                
dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp................................

qvedtskEFPTRTITHYQYHSWPDQGIPQgHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAvlanrTLVLNQAVAELRDQRWCAIQTVEQ
       |. .|....|.|..||| |.|    ...|......|...|..||||||.||| ...|  .. .       . | .||...| .|.....| .|
.......ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnq

MYWVQV
....| 
yfflql

subfamily_PTPN1_pd Subfamily PTPN1 1049-1245 2.2e-37 123.3 In-house 57-263 (290) alignment
Range on Protein: 1049-1245
Range on HMM: 57-263/290.0
NWINTS-PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTG-QIVDLE--RYKLKTVTQEQIlgDSTSKRTIQVE
..||.|  ...   ...| |||||||| | || ||  .|  .|||| ..||||. ||..|.|     . . ||  ..|.| ...|.   .    |....|
dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerk..syytvrllele

DTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES------KKPIVVHCSAGIGRTVSFIATQYIPSAVLA--N-RTLVLNQAVAELRDQRWCA
. . .  ||.|.|. | .||| |.|.  |. ....   .||      . | |.||||||||. .|.    .   . .  .  .. ... . ||| .|   
nlktq.etreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGl

IQTVEQMYWV
||| .|. . 
iqtadqlrfs

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1050-1245 2.7e-37 123.6 In-house 86-282 (298) alignment
Range on Protein: 1050-1245
Range on HMM: 86-282/298.0
WINTSP-DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVD---LeryklkTVTQEQILGDSTSkRTIQVED
.|| |  .   ... |||||.||..|  ||| ||  ....|.||| . .|... |.|.|.| .  .  .   .      .. ...  .| .. |...|..
YiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitv......sllskeefadliv.rklkvsk

TSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES----K-KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
...|  .|.. . .. ||||.|.|. .   .||..  . |    . ||..|.||||.||. .||| . .   | ..... . |.|  || .|  |.|| |
kkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqtee

QMYWV
|  ..
qYvfi

0043147 (Phosphotyrosine protein) phosphatases II 1043-1246 6.1e-37 122.4 In-house 5-154 (172) alignment
Range on Protein: 1043-1246
Range on HMM: 5-154/172.0
RIPIHANWINTSPdvdgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFvekeeekcheyfpvrtgqivdleryklktvtqeqilgdstskrtiq
.  |.|......      ...||||||||.|| .||| |.. ... ..|.|...                                              
sdyinasyldlyy....ipdrfiatqgplrntladfwrmlkelgithivnltel..............................................

veDTSKEFPTRTITHYQYHSWPDQGIPqGHAQCFDLMNMAKE-----SKKPIVVHCSAGIGRTVSFIATQYIPsavlanRTLVLNQAVAELRDQRWCAIQ
   . .|. .|.. .|.|..|||.| |   ..  ....  .|     ...|..||||||.|||. ..|  ..       . | | .|||..|..|..|.|
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

TVEQMYWVQ
. .|.....
npsqyrfly

0051429 (Phosphotyrosine protein) phosphatases II 1046-1272 6.8e-37 122.9 In-house 7-244 (272) alignment
Range on Protein: 1046-1272
Range on HMM: 7-244/272.0
IHANWINTSpdvdGN---TQKFIATQGPLPNTSDDFWTMvQFHKVETVVMLCQFVEKEEEKCHEYFP--------VRTGQIVDLERYKLKTVTQEQILGD
|.|.....     |.     ......||||.| .|||.. . ... |.|.|.. .|.. .||. | |        .      . . ..|   ... .| .
iNardvggy....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

STSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHaqCFDLMNMAKEsKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLV--------LNQAVA
 .  |..... ...   .|...|..|..||| |.||    . .|...  . ..|..||||||..||  ..|  ..   | ..  .         | .||.
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeave

ELRDQRWCAIQTVEQMYWVQVGSVYRLSKEKNIDMKHYKEQFEMLD
|||.|| .|.|| ||.....   .  | .  .... ...  ....|
elraqrpgavqteeqylflyeallellrsllsvraeyllaaldaid

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1014-1247 1.5e-36 120.9 In-house 39-266 (288) alignment
Range on Protein: 1014-1247
Range on HMM: 39-266/288.0
AYLPKEKNRRPLATPCNPETAVEvMSDGTRIPIHANWINtspdVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTG
... .  . |    |.   | |  .|| .   |.|| .        . ...| .| ||  | . .| |.    || .||||...||  ||  ||||.. |
sfianptrdryenlprcditrvk.lsddpdfyiaanvvs....sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG

QIVDLERYklKTVTQEQIlgdSTSKRTIQV--EDTSKEFPTRT-ITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIP
. . . |.   ||....    .  .....|     |||  ..  . .  .. |.|.|.|. .   . |... |. .||||||.|||.|||  .| .  . 
ekarigrl..ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililial

SAVLANRTLVLNQAVAELRDQRWCAIQTVEQ-MYWVQV
 ..  .  | ... .|.||..|  ||||  | .|  ..
eslrlddflgirsllaklreerfkaiqtemqylyvhrc

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1045-1246 2.8e-36 119.9 In-house 70-270 (315) alignment
Range on Protein: 1045-1246
Range on HMM: 70-270/315.0
PiHANWINTSP--DVDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQIlGDSTSKRTiq
| . ..||.|    || . . .||.||||. . |||| ||  .|| |.||. .  | .  ||  |.| | .. |..  .|....  |.  .| . ..   
P.dsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslead.tdgvarkl..

VEDTSKEfpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK----KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQT
|   |.|  .||.| .|.. |||.|...  .  . |.   | ..     ...||||||.|||  .|. . . . .  .|.. . . | .||..|   .||
vtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqt

VEQMYWVQ
 |.  .. 
eeeyafiy

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1048-1245 3.8e-36 119.5 In-house 37-234 (250) alignment
Range on Protein: 1048-1245
Range on HMM: 37-234/250.0
ANWINTS-PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEkCHEYFPVRTGQIVDLERyklKTVTQEQILGDSTSkRTIQVEDT
...|| |  ..  ... ||||||||..|  ||| ||  .|..|.||| ...|.|.. .|.|.|| . ..    .    .. .... .| |. |....  .
sdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvt...vsllskeefadytk.rklklska

sKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES-----KKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQ
 |.   |.. .... .|||.|.|.     ..|..  . |     ..|..|.||||.||. .||| . .   .  .... . . .  || .|  |... ||
.kkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleq

MYWV
  .|
yvfv

subfamily_PTPN23_pd Subfamily PTPN23 1056-1242 5.6e-36 118.8 In-house 77-269 (288) alignment
Range on Protein: 1056-1242
Range on HMM: 77-269/288.0
DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTvTQEQiLGDSTSKRTIQVEDTSKEfPTRTI
|.   . .|||||.||..|. ||| ||   |....||| .  |....|...|.| ..|. |  . ...    ...   .  ..|....|  ...  ....
dlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtl.ksvr.etethvervlkletldad.avksv

THYQYHSWPDQGIPQGHAQCFDLMNMAKE--------SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLV-LNQAVAELRDQRWCAIQTVEQM
.| |..|||. |.|.   . ..... ...        ||.|.|||||||.|||  |     .  .. ..  |. . | |  || ||   .|..||.
shlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeql

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1043-1245 6.4e-36 118.8 In-house 63-270 (287) alignment
Range on Protein: 1043-1245
Range on HMM: 63-270/287.0
RIP---IHANWINTSpDVDG--NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGqiVDLERYKLKTVTQEqiLGDSTS
|..    | ..|| .  .||  . ..||....|. ||  .|| ... ..|...|||||  |..||.|..|.|  .   | |  |... . .|    ..  
rvllkgehpdyinav.fidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee..vnagyi

KRTIQVEDTSKEFPTRTITHYQYHSWPDQG-IPQGHAQCFDLMNMAK----ESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQR
.|...|. ..|. ...... ||. .|...| ...  .  . . .| |    ... .||||||...||.  |.| .     .  . .. . | . . | |.
erklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqk

WCAIQTVEQMYWV
  ..|||||   .
pgsvqtveqykfi

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1045-1245 6.9e-36 118.6 In-house 78-275 (290) alignment
Range on Protein: 1045-1245
Range on HMM: 78-275/290.0
PIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIvdLERYKLKtVTQEQILGdSTSKRTIQVE
 |.| .|.       . ...||||||..||  ||| ... .||  .|||.. .|....||. |.| .  .   .. ...| ...|..|  .  .|...|.
yinAcyikgy....kekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsik.llneetln.eyierklevk

DTSKEFPTRTITHYQYHSWPDQG---IPQGHAQCFDLMN--MAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTV
..... .....|.||  .|...|    ||.  . .  |.  . |. ...||||||...||.  |.|..     .  .    . | . ..| |.   .|||
nknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtv

EQMYWV
.|.  .
qqyqgi

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1028-1247 1.6e-35 117.4 In-house 45-264 (285) alignment
Range on Protein: 1028-1247
Range on HMM: 45-264/285.0
PCNPETAVeVMSDGTRIPIHANWINTsPDVDGNTqkFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLK--T
 |  || | |. .  |  |||.|.   |  | .|  .|.||||||.|  ||| |.   |.  |.||| ..|   |||  |.| . |..| . .|..    
rcieetrv.vlknhdrdyihaswmrm.pgkdqst..yittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlte

VTQEQILGDSTSKRT-IQVEDTSKEfPtRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE---SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVL
. .| | |      | |. ||.| | |   . | |   ||||  |.      .| .  |.    .|||.||||||.||| .|.  .|    .. |  . .
ckeeaiagtilnaltvintedasse.p.lymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniem

NQAVAELRDQRWCAIQTVEQMYWVQV
 . | |.|  |. |.|.  |. .. |
ldivremramrfqavqshmqflflyv

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1047-1245 2e-35 116.9 In-house 70-268 (515) alignment
Range on Protein: 1047-1245
Range on HMM: 70-268/515.0
HANWINTS--PDVDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQILGdsTSKRTIQVE
| ...|.|  | .| | . .||.|||.. . |||| .|  ..| |..|. .  | .  || .|.| . |. | .  .|...|. |   |  . ||...| 
hsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactg..gikrkltvl

DTSKefpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK----KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
  ..   .||.| .... |||.|.|.     . |.   | ..     |...|||||.|||  .|. . . . .   |.. . . |  .|..|   .|| |
kgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqe

QMYWV
|  ..
qyafi

subfamily_PTPRG_pd Subfamily PTPRG 1005-1260 8.5e-35 115.0 In-house 35-295 (563) alignment
Range on Protein: 1005-1260
Range on HMM: 35-295/563.0
TSVSVEKSNAYLPKEKNRRPLATPCNpETAVEVMSDgTRIPIHANWINTSpDVDGN--TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEE
... .|.|..   |.|||    .. . .. |.. .  . .  . ..|| .  .||   ...||||||||..| |||| |.  ..|...||. ..||.. .
kdldaehsqkpenkrKnRylnivayd.rsRvklspl.pgkkkklDYinAn.yidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrr

KCHEYFPVrtGQIVDLERYKLKTVTQEQILgdSTSKRTIQVED-----TSKEFPTRTITHYQYHSWPDQGIPQghAQCFDLMNMAKESK------KPIVV
||. |.|    . ....  ... ...|..   . ..||.....     ...    .....|.| .|||.| |.   . ..|... |.|.       ||||
kcdvYWPk..desetygalqvtlieeevla..lytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe..hslpvLifvkkssaankaeaGPivv

HCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVYR-LSKEKNID
|||||.|||  .|. . .   . .. .  . . .  .| ||   .|| || ...    .   .|||... 
HcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell

0049260 (Phosphotyrosine protein) phosphatases II 1061-1246 1.2e-34 114.6 In-house 8-143 (152) alignment
Range on Protein: 1061-1246
Range on HMM: 8-143/152.0
TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFpvrtgqivdleryklktvtqeqilgdstskrtiqvedtskefptrtitHYQY
 ..|||||||.||| .||| |.. ... |.|||....|. ..||..|.                                                .|..
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................qylh

HSWPDQGIPQGHAQCFDLMNM----AKESKKPIVVHCSAGIGRTVSFIATQYIPsavlanRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
. ||| | |. .    .|. .    |.....|..||||||.|||  ..|  ..       . . | .||| .| .|..|... .|.....
lpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Ptp69D_pd Subfamily Ptp69D 1049-1246 2.2e-34 114.0 In-house 77-279 (307) alignment
Range on Protein: 1049-1246
Range on HMM: 77-279/307.0
NWINTSPdVDG--NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRtgQIVDLERYKLKTVTQEQiLGDSTsKRTIQVEDT
..|| |  . |  ...|||| |.|. .| .||| |.   .|...||| .  ||...||. |.|.   ..|  .    |.| .|.  .| . .|...|  .
dYinasf.ikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseek.hsdyi.iReldvskk

SKEF----PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMA----KESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQT
 .|      .| .. |.| .|.|  .|.     ..|....    | .. ||||||||| ||.  |.| . .   . |. .. . . | .|| ||   .| 
keesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs

VEQMYWVQ
 ||  .. 
leqYvfly

0046846 (Phosphotyrosine protein) phosphatases II 1046-1246 3.2e-34 113.6 In-house 15-166 (176) alignment
Range on Protein: 1046-1246
Range on HMM: 15-166/176.0
IHANWINTSpdvdgntqKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVdleryklktvtqeqilgdstskrtiqved
|.||.| .|        ..||||||||.|  ||. |.. .....||.|.. ||..  ||. |.|. ..  .                             
inanlilgs........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

tskefptrtitHYQYHSWPDQGIPQGhAQCFDLMNMAKESK---KPIVVHCSAGIGRTVSFIATQyipsAVLANRTLVLNQAVAELRDQRW-CAIQTVEQ
           .|... ||| |.|.  .....|... .|     .|..||||||||||  ..|       .  .. | ...|.|..|.||. .|.|| ||
...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

MYWVQ
.....
yrfly

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1060-1264 3.4e-34 113.6 In-house 102-303 (319) alignment
Range on Protein: 1060-1264
Range on HMM: 102-303/319.0
NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCqfvekeEEKCHEYFPVRTGQIVDLERYKLKTVTQEQIlgdsTSKRTIQVEDTSKEFPTRTITHYQ
. .|.||.||||.|| .||| |.  ... |.|.|       ..|| .|.| .. .  .    |...|.. .        | |.. . .||   | || . 
rkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae....yvvrdielsedgkekdirkitqfh

YHSWPDQGIPQGHAQCFDLMNM------AKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVY-R
.  |||.| |.  .. . |..        .. ...||||||||.|||  .|. . . . .  .. . . . | .||.||   .| . | ... .  .  .
flGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

LSKEKNIDMKHY
|    .. |  .
lfghsdvampdf

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1060-1265 4.4e-34 113.3 In-house 66-268 (284) alignment
Range on Protein: 1060-1265
Range on HMM: 66-268/284.0
NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCqfvekeEEKCHEYFPVRTGQIVDLERYKLKTVTQEQIlgdsTSKRTIQVEDTSKEFPTRTITHYQ
. .|.|||||||.|| .||| |.  ... |.|.|       ..|| .|.| .. .  .  . |...|.. .        | |.. . .||   |.|. . 
rkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee....yvvrdielsedgkekdirkirqfh

YHSWPDQGIPQGHAQCFDLMNM------AKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVY-R
.  |||.| |.  .. . |..        .. ...||||||||.|||  .|. . . . .  .. . . . | .||.||   .| . |.... .  .  .
flgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleeh

LSKEKNIDMKHYK
|    .. .  . 
lfghsdvalpdfp

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1034-1245 4.5e-34 112.6 In-house 49-258 (283) alignment
Range on Protein: 1034-1245
Range on HMM: 49-258/283.0
AVEVMSDgTRIPIHANWINTSPDvDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGqiVDLERYklkTVT-QEQIL
 ||. |. .|  | | .|  | . . . .|.|..|.|| .|  ||| ||  .|. ..||| .. | ...||  |.| |    .|   .   ||| ...  
rvelkse.srdyinavfipvsks.ykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGs..edyGef...tvtlrkett

GDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGiPQGHAQCF---DLM--NMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAE
 .| ... . .   |    |  ..|||.  | . | .|     .   ...  .  .. | |||||||.|||||  |||       .|..  . . . |  
snsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvki

LRDQRWCAIQTVEQMYWV
.| ||  |.|| .|   |
mreqrmmavqtldqyklv

subfamily_PTPN14_pd Subfamily PTPN14 1051-1245 1.2e-32 108.2 In-house 79-288 (300) alignment
Range on Protein: 1051-1245
Range on HMM: 79-288/300.0
IN---TSPDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVR--TGQIVDLERYKLKTVTQEQILGDSTSKRTIQVED
||    .  | |.....|..||||..|  ||| ||  ..|. .||| .  |.  ||...|||      . |. ...|. |  .|.     |.. ...   
inassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp

TSKEfptRTITHYQYHSWPDQGIPQGHAQCFDLMNM-------------AKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQR
...|   ||. | ||  |||.|.|.   . .. ...             .|||| |..||||||.|||   | .. . ...  |... .....| || ||
skee...rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqr

WCAIQTVEQMYWV
   .||. |  .|
mllvqtlaqYkfv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1048-1245 1.4e-32 107.4 In-house 74-280 (302) alignment
Range on Protein: 1048-1245
Range on HMM: 74-280/302.0
ANWINTSPDVDGNTQKFIATQG---PLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQILGDSTSKRTIQV-
 .|| .   .||  .|   ..    |  .| . .|.... ..|  || ||.|||.||.|| ||.  . |. . . || .|||  .. | . | |..... 
ikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfkly

--E---DTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQT
  |   .  |.   .|.   .. .||| | |.   . .|...  .  || ..||||||.||| ...| .|     . ...  | . |  .|. |. |.|.
tveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqd

VEQMYWV
 .|. ..
eqqliyl

0036282 (Phosphotyrosine protein) phosphatases II 1060-1246 1.4e-31 104.9 In-house 15-163 (174) alignment
Range on Protein: 1060-1246
Range on HMM: 15-163/174.0
NTQKFIATQGPLPntsddFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVrtgqivdleryklktvtqeqilgdstskrtiqvedtSKEFPTRTITHYQ
 | ..||.||||.     || |.. ....|||||.. .|.. .||. |.|                                      .|...|.. .|.
itprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................lredlerlgiqyl

YHSWPDQGIPQGHAqCFDLMNMAKES-----KKPIVVHCSAGIGRTVSFIATQYIPSAVLaNRTLVLNQAVAELRDQRWCAIQTVEQMYWVQ
|  ||| | |  .   ..... ..|      ..|..||||||.|||  ..|  ..    | ...    . |.||| || ...|| .|.....
ylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1048-1264 2.3e-31 104.0 In-house 79-296 (297) alignment
Range on Protein: 1048-1264
Range on HMM: 79-296/297.0
ANWINTSpDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEeKCHEYFPVRTGQIvdLERYKLKTVTQEQILGdsTSKRTIQVEDTS
....| |  | || ...|.|| | ..| .|||.||  ..| |.||| .  |... ||  |.. .. .   .    ... . ..  |   .||...|.  .
sDyvnas.fvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereG..fikrelevtkgk

kEFPTRTITHYQYHSWPDQGIPQ--GHAQCFDLMNMAKE-----SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
    .| .  ||. .|||. ...    ..  .|..  ..     .. |..|||.||.|||  ... . . . .  . .. . . |  ||..|   .|| |
.akarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtke

QMYWVQVGSV-YRLSKEKNIDMKHY
|  .| |  . . ||.. .|.....
qykfvyvavleallsedtriqasyf

subfamily_PTPRK_pd Subfamily PTPRK 1047-1245 2.6e-31 103.6 In-house 70-269 (314) alignment
Range on Protein: 1047-1245
Range on HMM: 70-269/314.0
HANWINTSP-DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQILgdstsKRTIQVED
....||..  |   ....||.|||||..|  ||| .|  ..  ..||| ..||.   || .|.|  | .  |..   ..| ......     .|. .|| 
ssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelv.....vrifrvek

TSKEF-PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMA----KESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
...    .|.. ..|. .||| ..|.     ..|.       .|.. .|||||||| |||  ||| . .   .  .... . .|| .||...   ..| |
largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmvetee

QMYWV
|  ..
qykfi

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1039-1259 5.1e-31 103.0 In-house 72-295 (325) alignment
Range on Protein: 1039-1259
Range on HMM: 72-295/325.0
SDGTRIPIHANWINTspdvDGNTQKFIATQGPLPNTSDDFWTMVQFHKvETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQIlGDStSK
 |.    | |.....    | . . |.|.| ||..| .|.| .|   .  .||..   .......|  |.| . |. . .   ..| .| |.|  |   .
ddpssdyinasylrd....dkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdy.vh

RTIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAK----------ESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAEL
| ..| ...|   ||..  .|. ||.| | ..  |    .... |          ..  ||.||||||.|||  ||.   .   |. .  . . . |  |
rvldvkqvkkG.etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkkl

RDQRWCAIQTVEQMYWVQVGSVYRL-SKEKNI
| .|   ..||.|   .  . |  . | . ..
rkdrpsmvetvdqyiliyealveaymsgntdv

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1049-1245 1e-30 101.7 In-house 30-231 (237) alignment
Range on Protein: 1049-1245
Range on HMM: 30-231/237.0
NWINTS--PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPvRTGQIVDLERYKLKTVTQEQiLGDSTSkRTIQVEDT
..||..   ..||  .|.||.|||| .. |||| ||   |   .|||  ..|..|.|||.|.|  | |      . .    .|. . | |  |.. .   
dyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaaygvltvslkkkee.fsdytv.rslllskr

SKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLM-NMAKESK-----KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
 .    | |  ||. ||||.|.||  |  . .  |. ..|.      | ..|||||.|||  |.  . .      .. . . . |  . ..|   ||| .
ltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkd

QMYWV
|  ..
qyvfi

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1016-1267 1.4e-30 101.5 In-house 16-273 (290) alignment
Range on Protein: 1016-1267
Range on HMM: 16-273/290.0
LPKEKNRRPLATPCNPETAVEVMSDGTRIP---IHANWINTSpdvdgNTQKFIATQGPLPNT-------SDDFWTMVQFHKVETVVMLCQFVEKEEE---
. |..  . |. |   .| |     |.|.    |||| .  .     | ...|.|| |. ..         .|| |..  ||. |||||.| ||...   
vkkhemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcp.....nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl

-KCHEYFPVRTGQIVDLERYKLKTvtQEQILGDSTSKRTIQVE-DTSKEFptrTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRT
  | .|.| . |... ..  ..|   ....  |   .|.. |. |  .||   |.||.....| .  ... .    .|... | || |..|||  || | 
faCakYvpesvgeelkfkgltvkC..kskekeddvetRelvvkfddeeef...tvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrs

VSFIATQYIPSAVL-ANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVYRLSKEKNIDMKHYKEQ
  . | .     .   .  ..|.... .|| ||  ||.. ... .|  | | .. ....  .....|.
AalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetek

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1047-1245 2.7e-30 100.4 In-house 76-271 (315) alignment
Range on Protein: 1047-1245
Range on HMM: 76-271/315.0
HANWINTSpDVDGNT--QKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRtgqivDLErYKLKTVTQ-EQILGDSTSKRTIQV
|....|..  .|| .  ...||.|||.... .||| .|  ... ..||| . ||.|..|. .|.| .     ..  |   |||. ..   .  . ||. |
hsdyvnan.fidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.....kvi.yGkitvtrkseevnteytvrtlsv

EDTSKefpTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAK----ESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTV
   ..    |..  ..| |||| |.|.      .|.  .|    .|  .||||||||.||| .||. . .   . |.. . . ...  .|..|  ..|..
vfgdn...irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqva

EQMYWV
||  ..
eqyqfi

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1044-1257 2.8e-30 100.1 In-house 68-279 (312) alignment
Range on Protein: 1044-1257
Range on HMM: 68-279/312.0
IPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGqIVDLERYKLKT--VTQEQILGDSTSKRTI
. ||||...       . ..|..||||| ||.  || ..      ....|| |||   ||| .|     | .|||| ... |  .|. .| | |  | | 
fyihanfvkic....tkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg.fvdledhrvyteycteieiggkskdkith

QVEDTSKEF--PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTV
.|             . |||. ||||.|.|.    .. |.   |  |||.. |||||.||| ...  . . .|.   |   . ..   || .|  .....
rvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvf

EQMYWVqVGSVYRLSKEK
 |. .. . .|  .   |
pqyvya.lrcvleflysk

0049772 (Phosphotyrosine protein) phosphatases II 1046-1246 6.4e-29 97.1 In-house 75-273 (314) alignment
Range on Protein: 1046-1246
Range on HMM: 75-273/314.0
IHANWINTSpdvdgntQKFIATQGPLPNTSDDF----------WTMV--QFHKVETVVM---------------------LCQFVEKEeekcheyfpvrt
|.|.....        .|||||||||..| .||          |.||  . ..| ..||                     |... ..             
inasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng............

GQIVDLERYKLKtvtqeqilgdstskrtiqveD--TSKEFPTRTITHYQYHSWPDqGIPQGHAQCFDLMNMAKE--SKKPIVVHCSAGIGRTVSFIATQY
.. .  .   ||                    .  ...|...|.. .| .. .|| | .   ..  ..... .|   ..|..|||.||.||| .|... |
neptaadlellk....................eelydpelferlgikylripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaay

ipsaVLANRTLVLNQAVAELRDQRW-----CAIQTVEQMYWVQ
    ..  . . |..|....| .|       .|.. ||.... 
....lmkllgvsleealedvrlkRpinpnpgfieqleqyefil

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1074-1241 8.8e-29 95.3 In-house 40-209 (255) alignment
Range on Protein: 1074-1241
Range on HMM: 40-209/255.0
TSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTqeqILGDsTSKRTIQVEDT-SKEFPTRTITHYQYHSWPDQGIPQGH
| | |. ...  | |.||||| | |.. |||..|||.   .   |.  .. |        |    ||...  | ..   |.|..||.|. |...  |.  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssad.vvlrtleitstlgekkkthtvkhysykGWieknaPela

AQCFDLMNMAKESkKPIVVHCSAGIGRTVSFIATQYIPS----AVLANRTLVLN--QAVAELRDQRWCAIQTVEQ
 .   .. ....| |..|||||.||||. .|. ....      ..    |  |.  . . ||| .| .||.|  |
reilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlq

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1045-1243 1.1e-28 94.7 In-house 68-259 (281) alignment
Range on Protein: 1045-1243
Range on HMM: 68-259/281.0
PIHANWINtSPDVdgnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKlktVTQE-QILGDStsKRTIQV
 ||||.|  || .    . .| ||||  .|  ||| |.   .  ..||||||.| . ||| ||||  .   ......    |. |   .  |    | ..
yihanyir.spfl...krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdkls...vsyedstvnks..lvttrl

eDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLV-LNQAVAELRD-QRWCAIQTVEQ
 . | |  || |||. .. |||  .|.     . ..   .    | |.|||||.||. ...| .    .. .  ||  ..| |. ||   | ...||..|
.nlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqq

MY
  
ym

subfamily_PTPRN_pd Subfamily PTPRN 1042-1245 3.1e-27 90.1 In-house 78-284 (297) alignment
Range on Protein: 1042-1245
Range on HMM: 78-284/297.0
TRIPIHANWINTSP--DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLerYKLKTVTqEQILGDSTSKR
.    . ..||.|.  | |  .  .|||||||..|  ||| ||  . |  .|.|..  |.. ..|..|.|    .. ..  |... |. | |  |    |
easaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhi..yevhlvs.ehiwcddylvr

TIQVEDTSKEfPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES----KKPIVVHCSAGIGRTVSFIATQYIPSAVL-ANRTLVLNQAVAELRDQRWC
.. . .  ..  |||.| . . |||..|.|      ...      |      |||||||.| |||  .|. . . . .|   . . .  ..  |||||  
sfylknlqts.etrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpg

AIQTVEQMYWV
 ..| .|. ..
lvktkdqfefa

0051082 (Phosphotyrosine protein) phosphatases II 1046-1244 3.9e-27 90.1 In-house 6-144 (151) alignment
Range on Protein: 1046-1244
Range on HMM: 6-144/151.0
IHANWINTSpdvdgntqkFIATQGPLPntsdDFWTMVQFHKVETVVMLCQFVEKEeeKCHEYFPVRTgqivdleryklktvtqeqilgdstskrtiqved
|.....            .....|||.    ||. ... ... |.|.|.. .| .  .|.||.|                                    
infsyvtgg.........lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

tskefptRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKES-KKPIVVHCSAGIGRTVSFIATQYIPSAvlanrtLVLNQAVAELRDQRWCAIQTVEQMYW
       ....|.....|||.|.|.  ... ...... .  ..|..||||||.|||  ..|   .         . |..|..|.| .|. ..|. .|.. 
.......ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf





subfamily_hpo-7_pd Subfamily hpo-7 1073-1241 6.5e-27 89.1 In-house 45-215 (263) alignment
Range on Protein: 1073-1241
Range on HMM: 45-215/263.0
NTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTVTQEQilgdSTSKRTIQVED-TSKEFPTRTITHYQYHSWPDQGIPQG
.| | |. ...  | |.||||| | |.. ||| .|||.   .   |.  .. |    .     . ..|...    ..   |.|..||.|  |...  |. 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhysykgWiekndpel

HAQCFDLMNMAKESkKPIVVHCSAGIGRTVSFIATQYIPS----AVLANRTLVLN--QAVAELRDQRWCAIQTVEQ
  . . ....|..| |..|||||.||||. .|  .  .      ..    |  |.  . . ||| .| .||.|  |
areilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmq

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1047-1247 7.5e-27 89.0 In-house 34-234 (239) alignment
Range on Protein: 1047-1247
Range on HMM: 34-234/239.0
HANWINTS--PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERyklkTVTQEQILGDSTSkRTIQVE
|...||.|   | ||. . .||||| .  .| ||| |.   .   .|||  ..|  ..|||.|.|  | . ..|      |. . ... |    ||. . 
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv....tlrktevfadyii.rtfvms

DTSKeFPTRTITHYQYHSWPDQGIPQGHAQCFDLM-NMAKES---KKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
.  .    | . .|..  |||.|.||  .  . |  ...|.|    .| |.|||||.||| .|.  . .      ..|. . . |  .|..|   .|| |
qvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtse

QMYWVQV
|  ....
qyvfihl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1047-1246 7.8e-27 89.0 In-house 35-234 (239) alignment
Range on Protein: 1047-1246
Range on HMM: 35-234/239.0
HANWINTS--PDVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERyklkTVTQEQILGDSTSkRTIQVE
|...||.|   | ||. . .||||| .  .| ||| |.   .   .|||  ..|  ..|||.|.|  | . ..|      |. . ... |    ||. . 
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv....tlrktevfadyii.rtfvms

DTSKeFPTRTITHYQYHSWPDQGIPQGHAQCFDLM-NMAKES---KKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVE
.  .    | . .|..  |||.|.||  .  . |  ...|.|    .| |.|||||.||| .|.  . .      ..|. . . |  .|..|   .|| |
qvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtse

QMYWVQ
|  ...
qyvfih

0044763 (Phosphotyrosine protein) phosphatases II 1039-1246 1e-25 85.8 In-house 14-164 (178) alignment
Range on Protein: 1039-1246
Range on HMM: 14-164/178.0
SDGTRIPIHANWINtspdvDGntqKFIATQGPlpntsDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGqivdleryklktvtqeqilgdstsk
   .  .|.|..|      .|    ......|      |.. ... ... ..|.|.. .|   .||..|.| ..|                         
glersdyinaseil.....pg...lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.........................

rtiqvedtskefptrtiTHYQYHSWPDQGIPQ---GHAQCFDLMNMAK-ESKKPIVVHCSAGIGRTVSFIATQYIPSAvlanrTLVLNQAVAELRDQRWc
                  .|..  .|| | |.      ....... |  |...|..||||||.||. ...|  .. .       | |..|....| .|. 
.................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.

AIQTVEQMYWVQ
.... .|.....
ivpnpgqlrqLy

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1046-1243 1.2e-25 84.8 In-house 68-267 (287) alignment
Range on Protein: 1046-1243
Range on HMM: 68-267/287.0
IHANWINTSPDvdgnTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRtGQIVDLERYKLKTVTQEQILGDsTSKRTIQVED
| ||.. .  |     ..|||.|||.. |  |||..|  ... .|... . ||.   ||..|.| |  . . .  | .  . ...   .  . |.... |
inanyvasytd....deafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePe.ygvralrlid

TSKEfPTRTITHYQYHSWPDQGIPQG---HA----QCFDLMNMAKESK--KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAI
   .  .| .  ... ||||....      .    .. . ...|....   |.|||...||||.  ..||  . |  .    .   ..|. || .| . .
letr.earvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalv

QTVEQMY
|.| |. 
qavvqlr

WSN Domain of unknown function 169-234 1.4e-23 72.6 Pfam-A 2-67 (69) alignment
Range on Protein: 169-234
Range on HMM: 2-67/69.0
KSADYLNHTTLIAHIANGIALQAGLMKGSIPIDAAVSELLNFGSVKVSDITAFKPDQITALIGKLK
. ...|.. . ||...|||.|||||..|||||| ...||||.||...|.......|.. . . ||.
elqtvleklsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnkls

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1005-1243 2.1e-23 77.5 In-house 32-283 (301) alignment
Range on Protein: 1005-1243
Range on HMM: 32-283/301.0
TSVSVEKSNAYLPKEKNRRPLATPCNPETAVEVMSDgtripIHANWINTSpDVDG--NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEE
..|.....|..| . ||  ..       .  . ..       . ..||.|  .||  ...||||.|||. .|  ||| ..  .|. ..||...  |. ..
ctvglseenkalnrfknitvyddnriilkpkpnldl.....cqreyinas.yidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtks

KCHEYFPVRTGQIVDLERYKLkTVTQEQILGDST-------------SKRTIQVEDTSKEFPTRTITHYQYHSWPDQGI---PQGHAQCFD--LMNMAKE
||..|.|  . .  .    .  |...||.. | .              .....  ...... ..... .|  .||..|.   |.   |  |  ..   | 
kceqywpnseaeseefgpftv.tlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqki

SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMY
.. |.|||||....|.  ... .     . |.    . | .  .| ..  |..| ||  
gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqyt

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1033-1267 1.6e-22 74.4 In-house 62-251 (392) alignment
Range on Protein: 1033-1267
Range on HMM: 62-251/392.0
TAVEVMSDGTripiHANWINTSP--DVDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEeekcheyfpvrtgqivdleryklktvtqeq
  .||. | .    . ...|.|    .| | . .||.||| . . |||| ||  ..| |..|. .. | .                              
vkleviddip....dsdylnasyipsfd.nekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..............................

ilgdstskrtiqvedtsKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKE----SKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVA
                 |   .||.. ...  |||...|.  .  . ...  |       .|...|||||.|||   |. . . .     | . . . |.
.................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvt

ELRDQRWCAIQTVEQMYWVqVGSVYR--LSKEKNIDMKHYKEQ
..| .|   .|| ||  ..  |.|    | ..  | . |. ..
nirrkrpymvqtkeqyafi.ygavledllwrntlipvvhftdh

subfamily_CG7180_pd Subfamily CG7180 1019-1244 2.8e-22 73.7 In-house 44-281 (296) alignment
Range on Protein: 1019-1244
Range on HMM: 44-281/296.0
EKNRRPLATPCNPETAVEVMSDGTRipiHANWINTSpDVDGNTQ--KFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEeKCHEYFPVR----T
|||| .   | .    |    ||     . ..||..  ||. ..  ..| |..|  .| |.||..|  .....||.|..  . .. ....|.| .     
eknrdvkvvPyDynRvvLekldGee...ksdYinav.yvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqy

GQIVdLERYKLKTVTQEQILGDSTSKR--TIQVEDTSKEFPTRTITHYQYHSWPD-QGIPQGHAQCFDLMNMAKE---------SKKPIVVHCSAGIGRT
|.|. .|  . |. .. .|      |.  ..  ...  . .||.....|.  |.  . .|   .   .|.....           ..|.||..| | .|.
geif.veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

VSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYW
  ..| .     |  .  . . .||  || .|   ...||.  .
GvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYky

subfamily_ptpA1_pd Subfamily ptpA1 1050-1206 5.3e-21 69.8 In-house 77-249 (418) alignment
Range on Protein: 1050-1206
Range on HMM: 77-249/418.0
WINTSpDVDGN-TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQ----IVDL--ERYKLKTVTQEQILGDStsKRTIQ
.||.   .||   ..||.||||||||  ||| ||   ..  .||| .  |.   ||  |.| . |     |     | .   .|   ... |   .| | 
yinan.yidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdp..ereii

VED--TSKEFPTRTITHYQYHSWPDQGIPQgHAQCFDLM-----N------MAKESKKPIVVHCSAGIGRTVSFIAT
  .   . |  || ||.|||  |||. ||. |.| |  .     |       . . . ||.||||||.||| .| ..
trnirltfegetrditqyqyegwpdhnipd.htqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfcta

PTPc_DSPc_SM00012 1154-1242 7.6e-21 69.7 In-house 1-96 (105) alignment
Range on Protein: 1154-1242
Range on HMM: 1-96/105.0
TITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKK------PIVVHCSAGIGRTVSFIATQYIPSAVLAN-RTLVLNQAVAELRDQRWCAIQTVEQM
|..||.|..|||.|.|.     ..|..  |..|.      |.|||||||.|||  |.|  .. . . .. ... . | | |||.||  ..|| || 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1058-1246 8.7e-21 68.9 In-house 85-272 (439) alignment
Range on Protein: 1058-1246
Range on HMM: 85-272/439.0
DG--NTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEekcheYFPVRT-----------GQIVDLERYKLKTVtqeqilgdstskRTIQVE
.|  . . .||||||  .|.|||| .|  .|. |.|||...||        |.|  .            . ..| .| .. .            . ..  
kGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgf............kvfner

DTSKEfpTRTITHYQYHSWPDQGIPQGHAQCFDL---MNMAKESK--KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTV
||..    ||. ...| .|||. .|   .   |.   .| |....   |.|||||||.||| . || .     . ..  . ..  |  ||.||   .|..
dttek..ertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqal

EQMYWVQ
 |. ...
cqyvfiy

0048076 (Phosphotyrosine protein) phosphatases II 1141-1246 1.5e-20 68.7 In-house 34-136 (145) alignment
Range on Protein: 1141-1246
Range on HMM: 34-136/145.0
IQVeDTSKEFPTRTITHYQYHSWPDQGIP---QGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSavlanRTLVLNQAVAELRDQRWCAIQ
. .  . .|...|....|.| .||| |.|   .   ....... | ....|..||||||.||| ...|   . .     . . | .|....| ||..|..
lnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavp

TVEQMYWVQ
...|.....
npgqlrfly

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1025-1246 4.1e-20 66.6 In-house 59-283 (310) alignment
Range on Protein: 1025-1246
Range on HMM: 59-283/310.0
LATPCNPETAVEVMSDGTRI--PIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRT--GQIVDLER
    |  .. | .  | .|    ||||...|        . || .||||  |  ||| |.   . |....||. .|.   ||  |.|          .  
sdvvcldtsrvklkidksryedyihanyvktn....ylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirv

YKLKTVTQEQI---LGDSTSKRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANR
 .|   ..|     |  .     . |..   ..    ..  ..  |||.|.|. . .      .|.  . | |||||||..|.   .| ..    .    
tnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrgl

TLVLNQAVAELRDQRWCAIQTVEQMYWVQ
 . ... ..||. .|   |||  |  ...
kvdaeevktellksraiciqtelqyliid

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1038-1244 9.2e-20 65.7 In-house 52-250 (267) alignment
Range on Protein: 1038-1244
Range on HMM: 52-250/267.0
MSDGTRIPIHANWINTSpdvdGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEeekCHEYFPVRTGQIvdlERYKLKTVTQeQILGDSTS
... ..  | | ....        ..||.||.|| ||  ||.|... .|| ..|.| .  . .    . ..| . ||    ..|.  || .  .  .   
lrtkeeeyinasyvegy....ktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqa...kkyqdltveh.slekeend

KRTIQVEDTSKEFPTRTITHYQYHSWPDQGIPQGHAQ-CFDLM--NMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWC
 . | .|   |.  .. .| | |. |  .   . . .  | ..  |  ..  .|.||.||.|.||. .|.  .     .  . .. . . . ..|.||  
yqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqrig

AIQTVEQMYW
 ..| |.  .
lvdtkeryiy

0048179 (Phosphotyrosine protein) phosphatases II 1145-1246 1.1e-19 66.0 In-house 39-138 (144) alignment
Range on Protein: 1145-1246
Range on HMM: 39-138/144.0
DTSKEFPTRTITHYQYHSWPDQGIPQG---HAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPsavlaNRTLVLNQAVAELRDQRWCAIQTVEQ
.  .||..|....|.. .||| |.|.      ....... | |...|..||||||.||| ...|   .       . | |..|.|..| .|..|... .|
eyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgq

MYWVQ
.....
lrfLl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1006-1170 5.1e-19 63.2 In-house 24-181 (297) alignment
Range on Protein: 1006-1170
Range on HMM: 24-181/297.0
SVSVEKSNAYLPKEKNRRPLATPCNPETAVEVMSDgtRIPIHANWInTSPDVDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCH
| |. | |. | |.. |  |||  .      |...  |  | |... . || . .  |.| .|||| .| |||||.|  . | ..||.... |   .|| 
sfssakrnsslrknryrdilatddtrvkllrvite..rdyinadyv.vfpdee.adlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

EYFPVrtgqiVDLERYKLKTVTQEQILGDSTSKRTIQVEDTSK--EFPTRTITHYQYHSWPDQGIPQ
 |.|      |. || |   |  | .   |    .... .        .| ..| |. |||| |.| 
pywps.....vvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvps

subfamily_egg_pd Subfamily egg 1028-1245 9.6e-18 58.9 In-house 50-262 (307) alignment
Range on Protein: 1028-1245
Range on HMM: 50-262/307.0
PCNPETAVEV-MSDGTRI--PIHANWINTSPDVdgntQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKeeEKCHEYFPVRTGQIVDL--ERYK
.|.  . |.. .  |  .   |||| ..  | .     .|| .| || || |||| ||   .|. .|||   .|   |.|. |.|    . . .    ..
hckdssrvklelrrGqylddfihanrvkGkpll....nefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslr

LKTVTQEQ---ILGDSTSKRTIQVEdtskeFPTRTITHYQyhsWPDQGIPQGHaQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRT-
....  ..    |   |  . .  .        | . |.|   .  .   . .   . .. ....  ||.||..  |. .. ...| .     .|   . 
ienlkvdskadplfrvtklklvGgd.....deerflehwq...gdvnnssdvy.splrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpit

-LVLNQAVAELRDQRWCAIQTVEQMYWV
  .. .||  || .|  ....| .  .|
kslvlravvflrlrrrlsvesvllylfv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1014-1145 2.2e-15 51.2 In-house 55-184 (350) alignment
Range on Protein: 1014-1145
Range on HMM: 55-184/350.0
AYLPKEKNRRPLATPCNPETAVEVMSDGTRiPIHANWINTS-PDVDGNTQ-KFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVR
  || |..|  |    ..  |..    .    | ||... . . |. |.. |.||||.|||.| |||....   ||. ...| . || . |||..|..  
nilPYehsrvkLkkslkssdakkhslstnD.YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg

TgqiVDLERYKLKTVTQEQILGDSTSKRTIQVED
.   .|    ||.   .. .  . .|... .|. 
s...ydditvklaskwenimgindsslysadvkk

subfamily_CG42327_pd Subfamily CG42327 1033-1184 5.4e-15 49.9 In-house 43-192 (319) alignment
Range on Protein: 1033-1184
Range on HMM: 43-192/319.0
TAV---EVMSDGTRIPIHANWINTSpdvDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIvDLERYKLKTVT-Q
| |   .. .|     ..|...      |     .||.| .| ..| ||| .|   .  ..| |..  |.  ..| ||.| . .   . . |    || .
trvvlqrigdddkdeyldasyvrGy...ddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld.ntslyGdilvtlk

EQILGDSTSKRTIQVEDTSKEFpTRTITHYQYhSWPDQGIPQGHAQCFDLMNMAKE
..  .|     |. .    ||  .| .||| |  |.. ..|  .|  . ..  ...
grevkdryaistlllkrvdkee.srelthywy.kwleaevPaeeaaliamllevrs

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1062-1220 2.5e-13 44.6 In-house 5-169 (199) alignment
Range on Protein: 1062-1220
Range on HMM: 5-169/199.0
QKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVdleRYKLKTVTQEQI--LGDSTSKRTIQVEDTSKEFPTRTITHYQ
...|||| || .|  ||| ||       .||. .   . |     |.|.         .|   .|| . |    | |    | ...|.    || |.|||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtg...kygslsvttktittkpdytitaliltnnttappstreishyq

YHSWPDQGIPQGHAQCfDLM--------NMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLV
. || ..  |.       ..        .  .|   |..|||| | | |  |.| .    .    .| |
ftswkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1062-1220 2.5e-13 44.6 In-house 4-168 (198) alignment
Range on Protein: 1062-1220
Range on HMM: 4-168/198.0
QKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVdleRYKLKTVTQEQI--LGDSTSKRTIQVEDTSKEFPTRTITHYQ
...|||| || .|  ||| ||       .||. .   . |     |.|.         .|   .|| . |    | |    | ...|.    || |.|||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtg...kygslsvttktittkpdytitaliltnnttappstreishyq

YHSWPDQGIPQGHAQCfDLM--------NMAKESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLV
. || ..  |.       ..        .  .|   |..|||| | | |  |.| .    .    .| |
ftswkekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsv

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1060-1253 3.6e-12 40.3 In-house 88-285 (302) alignment
Range on Protein: 1060-1253
Range on HMM: 88-285/302.0
NTQKFIATQGPLPNTS---DDFWTMVQFHKVETVVMLCQFVEKEEeKCHEYFPVRTGQIVDLERYKLKTVTQEQILGDStskRTIQVEDTSKEFPTRTIT
 |.. | .| |  ...   ..|| ||  .|. .||.| .  | ..   .|.|| ..|. .. ..  . .   |.  ..        .|   ...    ..
ltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek...tryviEvlPegcsnsvla

H-YQYHSWPDQGIPQGHAQCFDLMNMA----KESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWVQVGSVY
  |  . |... .|.  |.    .        ......|.    |.||  .|..     . . ..     .. |. .| || .|.....|   . .  ..
nvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll

RL
 .
yi

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1151-1247 2.2e-10 34.5 In-house 87-188 (440) alignment
Range on Protein: 1151-1247
Range on HMM: 87-188/440.0
PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESK-----KPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
 .||. .|.|..|||.|.|.  .  . ...  .||.      |..|||||| |||   || . |   .  .  . .   .  .|..|   .|| ||. .|
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

QV
. 
he

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1045-1245 2.3e-10 34.6 In-house 71-271 (303) alignment
Range on Protein: 1045-1245
Range on HMM: 71-271/303.0
PIHANWINTspdvDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPvRTGQIVDLERYKLKTVTQEQI-LGDSTSKRTIQV
 |||....     |  ..| | || ||. |. ||| |.   ||  |..|    | ..   .  || |  .....|   ..     .. |||  . . . |
yihasylel....d.sskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp.rnqdflkfeersirvgefkrvelgdgwvlkvlsv

EDTS-KEFptrtITHYQYHSWPDQGIPQG-----HAQCFDLMNMAKE--SKKPIVVHCSAGIGRTVSFIATQYIP-SAVLANRTLVLNQAVAELRDQRWC
 . . | |    .  ..|..|| . ||         | ..|  . .     .| |    .| ||. .|   .    |    . .| | . .  .|. |  
sngdyksf....lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlh

AIQTVEQMYWV
|.| . |.  |
avqnlsqfsvv

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1016-1109 1.2e-09 31.9 In-house 58-154 (349) alignment
Range on Protein: 1016-1109
Range on HMM: 58-154/349.0
LPKEKNRRPLATPCNPETAVEVMSDGTRIPIHANWINTS----PDVDgNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFP
|| |  |  |    ..  ...     .   .  ..||.     . ..   .|.|||| ||| | |||....   .|. |. | .  |.. |||. |. 
lPyehsrvklkkslksskvikastsesdsgklddyinanylkltris.vekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq

subfamily_eak_pd Subfamily eak 1061-1191 2.7e-09 30.9 In-house 92-216 (332) alignment
Range on Protein: 1061-1191
Range on HMM: 92-216/332.0
TQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKEEEKCHEYFPVRTGQIVDLERYKLKTvtQEQILGDSTSKRTIQVedtSKEFPTRTITHYQY
 .|.| |  .  .    || ||   |  ..|.| . ||.. ||   ||| .| . ..   .....  .| .  .    | ...   ||   |  . ||..
GrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver..kefvkrniletrllel...skGnethrvlhykv

HSWPDQGIPQgHAQCFDLMNMAKESKKPIVV
. | .  .|.   . . | .. ||   . ..
fGwtettlpk.yedflalrkvmkevGvllli

subfamily_CG42327_pd Subfamily CG42327 1182-1245 3.5e-09 30.8 In-house 243-307 (319) alignment
Range on Protein: 1182-1245
Range on HMM: 243-307/319.0
AKESKKPIVVHCSAGIGRTVSFIATQYIPSAV-LANRTLVLNQAVAELRDQRWCAIQTVEQMYWV
 .||. |.||||| |.|||   ||.      .  ..|.. . | |  .| .|  |..|.||  ..
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefi

subfamily_PTPDC1_pd Subfamily PTPDC1 1148-1251 7.9e-09 30.2 In-house 76-174 (182) alignment
Range on Protein: 1148-1251
Range on HMM: 76-174/182.0
KEFPTRTITHYQYhSWPDQGIPQGhAQCFDLM---NMAKESKkPIVVHCSAGIGRTVSFIATQYIPSavlanRTLVLNQAVAELRDQRWCAIQTVEQMYW
...  . |..|.. .|.| | .    . .|..   ..| . .  . ||| || |||   ||.  . .     . |  ..|.  .|..|  .||| ||.  
ealmeqgiyvynf.gwkDygvasl.eriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvya.....krltaekaiklvrskrpksiqtreqvel

VQVGSVY
|.  . .
vkefalf

0038934 (Phosphotyrosine protein) phosphatases II 1156-1246 1.5e-08 30.1 In-house 68-170 (194) alignment
Range on Protein: 1156-1246
Range on HMM: 68-170/194.0
THYQYHSWPDQGIPQGHAQCFDL------------MNM-----AKESKKPIVVHCSAGIGRTVSFIATQYIPSavlanRTLVLNQAVAELRDQRWCAIQT
. | .  ... ||   . .. |             ...     .. ... ..||| ||.|||  ..|   | .     . . ...|.| .|. |  ||..
ryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipn

VEQMYWVQ
.... ...
qdyleall

subfamily_DSP23_pd Subfamily DSP23 1175-1244 2.8e-08 28.5 In-house 73-137 (148) alignment
Range on Protein: 1175-1244
Range on HMM: 73-137/148.0
CFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYIpsavlANRTLVLNQAVAELRDQRWCAIQTVEQMYW
   ... |.| .. . |||  | ||| ...|  ..      .| |   .|.||.| .|  ...||||   
fvrvveeaeekneavsvhcllgrgrtgtmlacylv.....kerklaaaeaiaevrrlrpgsvetveqekl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1062-1114 6.1e-08 26.4 In-house 236-285 (440) alignment
Range on Protein: 1062-1114
Range on HMM: 236-285/440.0
QKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVEKeeeKCHEYFPVRTGQ
. ||||| ||  |  ||| .|. ... |..|| |. .|    |  |.|| |  
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrs

subfamily_DSP19_pd Subfamily DSP19 1160-1235 1.1e-07 26.3 In-house 63-133 (152) alignment
Range on Protein: 1160-1235
Range on HMM: 63-133/152.0
YHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIaTQYIpsavLANRTLVLNQAVAELRDQRWCA
    |.. . .   ...| .. |....  ..|||.||. |..|..   |.    .....| |..|. ..|..| |.
ilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv.iayl....mkkeelsleealelvrearpci

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1183-1243 2.1e-07 25.1 In-house 225-285 (297) alignment
Range on Protein: 1183-1243
Range on HMM: 225-285/297.0
KESKKPIVVHCSAGIGRTVSFIATQYIPSAVLANRTLVLNQAVAELRDQRWCAIQTVEQMY
.  . ...||||||.||.   . .. | . .  .|    .  .  ||.||   .||.||  
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfe

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1049-1098 2.3e-07 24.7 In-house 71-121 (347) alignment
Range on Protein: 1049-1098
Range on HMM: 71-121/347.0
NWINTSP-DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQFVE
..||.|    |  ....| || |||.|  ||| ||.  ||  || . . ..
tyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepik

DUF4231 Protein of unknown function (DUF4231) 930-987 2.8e-07 17.0 Pfam-A 47-106 (112) alignment
Range on Protein: 930-987
Range on HMM: 47-106/112.0
SGISITLIIIIVGSILALIGVAVGIY-FGVRWYEKKKAAEQMEHEIVVWV-KAQAYKSLE
..   ...  |.....|.. . .... .. ||......||....| . .  .|. |.. .
gsnwlkwvtvilsalvailaslatffklkerwrryrataEslkaekwqflaragpysdeq

DSPc Dual specificity phosphatase, catalytic domain 1151-1241 2.8e-07 25.5 Pfam-A 38-123 (133) alignment
Range on Protein: 1151-1241
Range on HMM: 38-123/133.0
PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIAtQYIpsavLANRTLVLNQAVAELRDQRWCAIQTVEQ
. .. .... .   .. | .   .. . .. |....| ..||| ||| |. ..|.  |.    .  . | ||.|.. ....| .  .....
seieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii.aYl....mktknlslneAyefvkerrskispnagf

DSPc Dual specificity phosphatase, catalytic domain 1151-1241 2.8e-07 25.5 In-house 38-123 (133) alignment
Range on Protein: 1151-1241
Range on HMM: 38-123/133.0
PTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIAtQYIpsavLANRTLVLNQAVAELRDQRWCAIQTVEQ
. .. .... .   .. | .   .. . .. |....| ..||| ||| |. ..|.  |.    .  . | ||.|.. ....| .  .....
seieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii.aYl....mktknlslneAyefvkerrskispnagf

PTPc_motif_SM00404 1148-1238 4e-07 25.0 In-house 42-127 (140) alignment
Range on Protein: 1148-1238
Range on HMM: 42-127/140.0
KEFPTRTITHYQYHSWPDQGIPQGHAQCFDLMNMAKESKKPIVVHCSAGIGRTVSFIATQYipsavLANRTLVLNQAVAELRDQRWCAIQT
|| . ..| ... .    . . .   .. | .. |..... ..||| ||. |....|.  .     .  | | |..|.  ....| .  ..
kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYl.....mryrqlslaeayefvkerRpiispn

subfamily_CDKN3_pd Subfamily CDKN3 1159-1246 5.2e-07 23.4 In-house 103-189 (202) alignment
Range on Protein: 1159-1246
Range on HMM: 103-189/202.0
QYHSWPDQGIPQgHAQCFDLMNM---AKESKKPIVVHCSAGIGRTVSFIATQYipsaVLANRTLVLNQAVAELRDQRW-CAIQTVEQMYWVQ
 ..  .| ..|.  |.| ....    . .. .  .|||  |.||.   ||       .. . |.  ..|...||| .   ||||| |  ...
hhypiadglvpd.iasclkileelrinlkayrktlvhcygglgrsslviacll....lylddtiepkdaidklrdlkgsraiqtvkqynyls

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1050-1111 8e-07 22.9 In-house 124-181 (244) alignment
Range on Protein: 1050-1111
Range on HMM: 124-181/244.0
WINTSP-DVDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQfVEKEEekchEYFPVR
.||.|     | | ..| || || .|| ||| |.   .|. .|.|   ||.|.    ||.|  
yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veeed....eywpds

PTEN_1 1152-1245 9e-07 23.9 In-house 92-185 (196) alignment
Range on Protein: 1152-1245
Range on HMM: 92-185/196.0
TRTITHYQYHsWPDQGIPQGHAQCFDLMNMAKE-----SKKPIVVHCSAGIGRTVSFIAtqyipsAVLANRT-LVLNQAVAELRDQRWCA-IQTVEQMYW
 . ....... ..| | |  .  .  . ...       ... ..||| ||.||..  .|      | |  .  |  ..|.. .|..|... ... .|  .
ksgveylhfp.ieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva......ayLmykgkltadeAlelvrekRppgapnspsqerl

V
.
l

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1183-1214 2.2e-06 21.6 In-house 259-290 (350) alignment
Range on Protein: 1183-1214
Range on HMM: 259-290/350.0
KESKKPIVVHCSAGIGRTVSFIATQYIPSAVL
..  .||.||||||.|||  ...  .. | ..
narsspilvhCsaGvGrtGtlvtlDsllsdfe

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1057-1167 2.4e-06 21.9 In-house 23-125 (130) alignment
Range on Protein: 1057-1167
Range on HMM: 23-125/130.0
VDGNTQKFIATQGPLPNTSDDFWTMVQFHKVETVVMLCQfVEKEEekchEYFPVRTGqiVD-LERYKLKTVTQEQIlGDSTSKRTIQVEDTSKEFpTRTI
. |.|.... || || .|| ||| |.    |. .|.|   ||.|.    ||.|      ..  |   . |.|. .   .      ...|.  .|   ...
llgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veeed....eywpdseP..lewyeediivtltdrde.fknikasnleiesdlnes.hqal

THYQYHSWPDQG
| .|   || .|
tmfqisnwpsdg