Gene Y71F9AL.4 in Caenorhabditis elegans

Synonym: CELE_Y71F9AL.4, Y71F9AL.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf11
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP228_AA protein Get Run
CeleP228_AA_157-431 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 155-466 4.5e-227 746.5 In-house 1-312 (312) alignment 
Range on Protein: 155-466
Range on HMM: 1-312/312.0
QRAEMIKKWASAVMMSTPQQLTKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQ
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||
qraemikkwasavmmstpqqltkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwq

MALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALR
.||||||||||.|||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
lalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalr

LLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQEWTKFKETYAKIK
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..|||||||||||||||||||||||||||||||||||||||
llsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfketyakik

AKKLKIKDKSRG
||||||||||||
akklkikdksrg
0050432 (Phosphotyrosine protein) phosphatases II 154-433 1.1e-73 243.6 In-house 26-302 (308) alignment 
Range on Protein: 154-433
Range on HMM: 26-302/308.0
EQRAEMIKKWASAVMMSTPQQLTKEYKAVGNiVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLaGDENFYIHANFVKIC--TKPERFVCTQGPMENTCTH
    ...|.. .|  ..  ..  .|. .| . . . ..... . ||.|||..| ..|. |  | .... ||.|..|...   .| .|..||||..||. .
lsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntved

FWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDI--VGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSC
||.|    ... |.||. .||.| ||||.|  .    |... .. .|..  ...       .| .|.|.|... . .|.. ...|... .||||| |.| 
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.......lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpsp

DTALRLLSAVKKD--KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
.  |..| .|.|   ..|.. |||||||||||..... ..  |.. .. .| . .  ||. |. .|||. ||..  |..||.|..|
eilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0036941 (Phosphotyrosine protein) phosphatases II 158-444 1.5e-72 239.7 In-house 5-291 (297) alignment 
Range on Protein: 158-444
Range on HMM: 5-291/297.0
EMIKKWASAVMMSTPQQLTKEYKavgniVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMAL
 ..|.. .| ...  ..|.. ..       . ....... ...|||..| ..|. |  | .... ||.|..|...  . .|..||||..||. .||.| .
llekllflalllkefeellplll.....lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

SLGSTSIIMLCGFVEDGSEKCAKYISDI-VGFVNLEDHRVYTEYCTEIeiggkSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLL
 ...|.|.||. .||.| ||||.| ..   .... .| .| .  ....      .| .| |.|.|. . .|.. ...|... .|||||.|.| .. |...
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfi

SAVKK------DKKPVIAHCSAGVGRTGTLALIESMIAALR---HPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQEWT
 .|.|      ...||. ||||||||.||..... |.  |.   . .. .... .  ||. |. .|||. ||..  ...||.|..| .. .  ....
elvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl
0040438 (Phosphotyrosine protein) phosphatases II 173-465 8.6e-72 237.4 In-house 18-311 (317) alignment 
Range on Protein: 173-465
Range on HMM: 18-311/317.0
QQLTKEYKAV-GNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIML
..| .|.. .  ..... ....... ||.||||.| ..|. |  |  ..    . ||.|..|..  .. .|..||||..||. .||.|   .|.|.|.||
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmL

CGFVEDGSEKCAKYISDiVGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKD----K
. ..|.| ||||.| ..  .... .| .| .  ..|       .. ||.|.|.|. . .... ...|... .||||| |.| |. |..|.||..     .
teleelgrekcaqYwpl.getltygdftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpg

KPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQEWTKFKETYAKIKAKKLKIKDK
.||. |||||||||||..... |.  |.. .. .|.. .  ||. |. .|||. ||..  ...||.|. |. ..   . ..|... ....  .. |.|.|
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklkek

SR
..
el
0047943 (Phosphotyrosine protein) phosphatases II 174-430 7.4e-70 230.8 In-house 13-272 (273) alignment 
Range on Protein: 174-430
Range on HMM: 13-272/273.0
QLTKEYKAVGNIVSDS--ECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFV
.| .|.... ..  .   ..... . ||.|||..| ..|. |  | .... ||.|..|. . .. .|..||||..||. .||.|    ... |.||. .|
llleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelv

EDGSEKCAKYISDIVG--FVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK------DK
|.| ||||.| .. .|  ... .. .|..  ...       || .|.|.|... . ||.. . .|... .||||| |.| .  |... .|.|      ..
elgrekcaqYwpleggelsltygkftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

KPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
.||. |||||||||||..... ..  |.. .. .|.. . |||. |  .|||. ||..  ...||.|
gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 158-430 3.3e-69 228.8 In-house 8-286 (288) alignment 
Range on Protein: 158-430
Range on HMM: 8-286/288.0
EMIKKWASAVMMSTPQQLTKEYKAVGNIVSDS--ECTAFLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKICTKPERFVCTQGPMENTCTH
| . |.  ..... . .| .|.... ..  |    .... . .. |||..| ..|. |  |      ... ||.|...... .. .|..||||..||. .
eellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntved

FWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDiVGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVK----ATGQESKLNHYQWASWPDHGMPD
||.|    ... |.||...||.| ||||.| ..  |.....| .|..  ...       .|..|.|.|.|. .     .|.. . .|... .|||||.||
FWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

SCDTALRLLSAVKKD----KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
| .  |..| .|.|     ..||. |||||||||||..... ..  |.. .. .| . .  ||. |  .|||. ||..  ...||.|
spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 175-434 3.5e-68 225.4 In-house 2-278 (284) alignment 
Range on Protein: 175-434
Range on HMM: 2-278/284.0
LTKEYKAVGNIVS----DSECTAFLKFKDLNRYPNIQCWDRGRFTLAG-----DENFYIHANFVKIC-----TKPERFVCTQGPMENTCTHFWQMALSLG
| .|.... ...     . ....... ...|||..| ..|. |  |       ... ||.|..|. .      .. .|..||||..||. .||.| .  .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

STSIIMLCGFVEDGSEKCAKYISDIVGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKA-TGQESKLNHYQWASWPDHGMPDSCDTALRLLSAV
.. |.||...||.| ||||.| ... ......| .|..  ...       || .|.|.|... .  ||.. ...|... |||||| |.| .  |..| .|
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.......kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlv

KKD------KKPVIAHCSAGVGRTGTLALIESMIAALRHPR---KQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKG
..       ..|.. |||||||||||..... ..  |.. .   . .| . .  ||. |  .|||. ||..  ...||.|..| 
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0039614 (Phosphotyrosine protein) phosphatases II 167-431 3.2e-67 222.4 In-house 26-290 (297) alignment 
Range on Protein: 167-431
Range on HMM: 26-290/297.0
VMMSTPQQLTKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENF-----YIHANFVKICTK-PERFVCTQGPMENTCTHFWQMALSLG
  .. ...| .|.. . ... | ..... . ||.|||..| ..|. |  | . ...     ||.|..|.   . . .|..||||...|. .||.|   .|
ekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqg

STSIIMLCGFVEDGSeKCAKYISDIVGfvNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVkaTGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK
.|.|.||. .||.|  |||.| .. .|  . .| .|..  ...       .| .|.|.|.|.   .|.. ...|.|. .||||| |.| .. |..| .|.
vtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh.......ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvr

K------DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
.      ...||. |||||||||||....  |.  |.. .. .|.. .  ||. |  .|||. ||..  ...||.| 
ealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0045450 (Phosphotyrosine protein) phosphatases II 159-431 4e-67 222.4 In-house 13-305 (307) alignment 
Range on Protein: 159-431
Range on HMM: 13-305/307.0
MIKKWASAVMMSTPQQLTKEYKAVGNIVS----DSECTAFLKFKDLNRYPNIQCWDRGRFTLAG-----DENFYIHANFV--------KICTKPERFVCT
.. ..    . . .. | ||.. . ..      . ....... ||.|||..| ..|. |  |       ... ||.|..|        ... .. .|..|
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNLEDhrvYTEYCTEIEIggksKDKITHRVLKVVVK-ATGQESKLNHYQWASW
|||...|. .||.|   .|.| |.||...||.|.||||.| .|  .... ..   .| .....|.    .|..|.|.|.|  .  ||.. ...|... .|
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn...ftvtllseeh....ldgytvrtlevtdldgtgesrtvthfhytgw

PDHGMPDSCDTALRLLSAVKK------DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRK---QNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
|||| |.| ...|... .|.|      ...||. |||||||||||....  |.  |..  .    .. . . |||. |  .||.. ||..  ...||.|.
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0043336 (Phosphotyrosine protein) phosphatases II 183-429 3.9e-64 212.1 In-house 31-276 (278) alignment 
Range on Protein: 183-429
Range on HMM: 31-276/278.0
GNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKC
 . . . ....... ||.|||..| ..|. |  |  ..    . ||.|..|.   .|..|..||||...|. .||.|   ||.|.|.||...||.|..||
sfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkc

AKYISdiVGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK----DKKPVIAHCSAGV
|.| .   |... .| .|..  ...       .| .|.|.|.|. . .|.. . .||.. .||||| |.| .. |..| ||..    ...||. ||||||
aqYwp..ggsltygdftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGv

GRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
|||||..... ..  |.. .. .. . .  ||. |. .|||. ||..  ...||.
gRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
DSPc_SM00195 178-430 3.5e-62 205.5 In-house 5-262 (263) alignment 
Range on Protein: 178-430
Range on HMM: 5-262/263.0
EYKAVGNIVS--DSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFV
|.. . .  |  ....... | |. ||| || . |. |  |  .|    . ||.||..|. .|......||||...|. .||.| .  ... |.||. ..
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EDGSEKCAKYISDIVgfvnlEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKK----PVI
|.|.|||..|  .       ..  .....  ..    | ||.|. |.|..  ... .. |...||. .|||||.||| .  |.||.||||.|.    |..
engkekcdrywpees.....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

AHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
 |||||||||||...|....  |..  | .... .  ||| |...|||. || .. ...||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 178-430 3.5e-62 205.5 In-house 5-262 (263) alignment 
Range on Protein: 178-430
Range on HMM: 5-262/263.0
EYKAVGNIVS--DSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFV
|.. . .  |  ....... | |. ||| || . |. |  |  .|    . ||.||..|. .|......||||...|. .||.| .  ... |.||. ..
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EDGSEKCAKYISDIVgfvnlEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKK----PVI
|.|.|||..|  .       ..  .....  ..    | ||.|. |.|..  ... .. |...||. .|||||.||| .  |.||.||||.|.    |..
engkekcdrywpees.....ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

AHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
 |||||||||||...|....  |..  | .... .  ||| |...|||. || .. ...||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0040439 (Phosphotyrosine protein) phosphatases II 189-431 7.4e-62 204.5 In-house 3-247 (249) alignment 
Range on Protein: 189-431
Range on HMM: 3-247/249.0
SECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISD
 ... ... ||.||||.| ..|. |. |   .    . ||.|.... .  . ||..||||...|. .||.|   ||.|.|.||. .|| | ||||.| ..
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

iVGFVNLEDHRVYTEYCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK------DKKPVIAHCSAGVGRTG
  |... .| .| .  ...       ||..|.|.|... . .|.. . .|.|. .||||| |.| ...|... ||.|      ...||. ||||||||||
.ggsleygdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

TLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
|....  |.  |.. .. .... . |||. |  .||.. ||.. ....||.|.
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0045098 (Phosphotyrosine protein) phosphatases II 174-430 3.2e-61 202.5 In-house 10-272 (278) alignment 
Range on Protein: 174-430
Range on HMM: 10-272/278.0
QLTKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTlagDenfYIHANFVKICtkPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVED
.|  |.. . .|.|. ..  .|. .|.|||..|...|. |     |   ||.|......  | .|..||||...|. .||.|  .||.|.|.||...||.
llefefllllgipseitpalylgnldknRykdilpydhsrVk...d...YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

GSEKCAKYISDiVGFVNLEDHRVYTEYCTEIeiggkskDKITHRVLKVVVK----ATGQESKLNHYQWASWPDHGMPDSC--DTALRLLSAVKK------
| ||||.|  .  |... .| .|... ....       |..|.|.|.|.      ..... ...|... .||||| |..   .  |.||  ...      
grekcaqywpe.ggsltygdftvtllseevl.......ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealklla

-----------DKKPVIAHCSAGVGRTGTLALIESMIAALrhPRKQNVKDSFVLLRKDRAR-SVQTFPQYVYALRCVLEFL
           ...||. ||||||||||||...  |.  |  ... .. . .  ||. |   .||.. ||..  ...||.|
slllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
0042113 (Phosphotyrosine protein) phosphatases II 190-430 1.1e-60 200.4 In-house 2-243 (245) alignment 
Range on Protein: 190-430
Range on HMM: 2-243/245.0
ECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDi
....... ||.|||..| ..|. |. |  |.    . ||.|..|. .  ...| .||||...|. .||.|  .||.|.|.||. ..|.| .|||.| .. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

VGFVNLEDhrvYTEYCTEIEIggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK-----DKKPVIAHCSAGVGRTGTL
 .... .|   .| .....|.    .|..|.|.|.|. . .... . .||.. .|||||.||. .. |..|..|.|     ...||. |||||||||||.
gesltygd...ftvtllseeh....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtf

ALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
...  |.  |.. .. .. . .  ||. |  .|||. ||..  ...||.|
iaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 156-447 1.4e-59 196.5 In-house 2-287 (288) alignment 
Range on Protein: 156-447
Range on HMM: 2-287/288.0
RAEMIKKWASAVMMSTPQQLTKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQM
. |.|  |   |.  . . | |||.   |  |    ..|..    .|| |. . |  |  |  | .|||.|| |     ..|..|.| |.. |   .|.|
kkevinawirlvlqiaveglkkeyrdspneasidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkm

ALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGfvnlEDHRVyTEYCTEIEIGGKSKDKITHrVLKVVVKATGQESK-LNHYQWASWPDHGMPDSCDTALR
 |. .   |.||| ..| | || |.|    .|    |  |.   .|| .    .  ||. . |  . .. .|.|.. . .  .  |.|.|.|..  . ||
llesdveyivmlcellekGkeksaeyfPsklG....ekari.grlctvvkkkradidklvk.vsllriskegeekvivkilhlleWdddgvPenylsplr

LLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKgLYKRNEQEWTKFK
||  .|. .||.. |.||||||||||.||  .. .|| .    ..  .  ||..| ...||  ||.|. ||||| |  |  || . ....|. 
llevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk.kykvlredfvkla
Y_phosphatase Protein-tyrosine phosphatase 199-428 9.9e-58 190.7 Pfam-A 3-235 (235) alignment 
Range on Protein: 199-428
Range on HMM: 3-235/235.0
DLNRYPNIQCWDRGRFTL--AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISdivgfVNLEDHRV
. |||..| . |. |  |   .... ||.||.||  .....|..||||...|. .||.| .   ...|.||.  .| |.||||.| .      . |.   
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.....eeeeeslt

YTEYCTEIEIGGK-SKDKITHRVLKVVVKATGQ-ESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMIAAL
| ... |..   |  ....| |.|..  |.. . . ....... .|||||.|.| .  |.|. .|.|.|    .||. |||||||||||..... ..  |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

RHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
.. .. .|..    ||| |. .||.. ||..  ...||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 199-428 9.9e-58 190.7 In-house 3-235 (235) alignment 
Range on Protein: 199-428
Range on HMM: 3-235/235.0
DLNRYPNIQCWDRGRFTL--AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISdivgfVNLEDHRV
. |||..| . |. |  |   .... ||.||.||  .....|..||||...|. .||.| .   ...|.||.  .| |.||||.| .      . |.   
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp.....eeeeeslt

YTEYCTEIEIGGK-SKDKITHRVLKVVVKATGQ-ESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMIAAL
| ... |..   |  ....| |.|..  |.. . . ....... .|||||.|.| .  |.|. .|.|.|    .||. |||||||||||..... ..  |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

RHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
.. .. .|..    ||| |. .||.. ||..  ...||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 159-452 3.1e-56 185.6 In-house 2-300 (307) alignment 
Range on Protein: 159-452
Range on HMM: 2-300/307.0
MIKKWASAVMMSTPQQLTKEYKAVGNIVSD-SECTAFLKFKDLNRYPNIQCWDRGRFTL--AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQM
..| |    .    |.|. |.. . .   .     ||    | ||| ...| |.||  .   |    |||||.. |..|| .|.|.|||.|||  .|| |
vvkpwvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwam

ALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRL
|.     |.||||  .| .  || .|     |  .   ..  |   ... ..  . |.    | .. |. ...   ..|.||  |||.|.|.   ||. |
aiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainl

LSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAAL-RHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSkgLYKRNEQEW---TKFKETYA
|.||. |. ||. ||||||||.||.  |  .   . .    ...|.    ||..|  ..||  ||.|  | .||..    |||   .|     ...| ||
leavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle..lyketyeellltknyeekya

K
|
k
0037934 (Phosphotyrosine protein) phosphatases II 191-429 6.7e-55 181.6 In-house 4-241 (243) alignment 
Range on Protein: 191-429
Range on HMM: 4-241/243.0
CTAFLKFKDLNRYPNIQCWDRGRFTLAGdeNFYIHANFVKICtkpERFVCTQGPMENTCTH----FWQMALSLGSTSIIMLCGFVEDGSEKCAKYISdiv
.  ..  .. |||..| ..|..|  | |  . ||.||....    .|. .||||...|. .    ||.|  .||.|.|.||. .|| | ||||.| .   
iallpenlsknrysdilpydhsrvkleg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

gfvnlEDHrVYTEYCTEiEIGGKSKDKITHRVLKVVVKA-TGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK------------KDKKPVIAHCSAG
     ... .| ... .  .. ...|..|.|.|... .  ....    ||.. .|||||.|||..  |..|..|.            ....||. |||||
.....gev.tygdftvt.llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRTGTLALIESMIAALrhprKQNVKDSFVLLRKDRAR-SVQTFPQYVYALRCVLEF
|||||||...  |.  |    . .. . . |||. |   .|||. ||..  ...||.
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 153-441 2.1e-53 176.0 In-house 2-298 (305) alignment 
Range on Protein: 153-441
Range on HMM: 2-298/305.0
KEQRAEMIKKWASAVMMSTPQQLTKEYKAVGNIVSDSECTAFLKFKD--LNRYPNIQCWDRGRFTLAGDE-NFYIHANFVKICTKPERFVCTQGPMENTC
| |.   | |.   ..  .|. | .|..|.  .       || . ..   ||| .. | |. |  | |     |||||.|   |.|.||.||| |.|.||
kkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektc

THFWQMALSLGSTSIIMLCGFVEDGSEKCAKYIS----DIVGFVNlEDHR--VYTEYCTEIEIGGKSKDKITHRVLkVVVKATGQESKLNHYQWASWPDH
. || | |     .|.||| ..| |..||..|..    |.. | . ....  |  | ......  ..| |.|. || |.  . ..  | .|| |  ||| 
adfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee.kgqkisvkfessvtlkfrkdakakvtetvl.viegpgekarkvthyhwidwpdr

GMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDS-FVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQ
|.| .  . | ||   .  | |.. |||||.||||.. ..| ..  |   .. .  |  .. .|..|  |.||  ||..  . .|...  |.|.. . .
gvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevk
subfamily_PTPRB_pd Subfamily PTPRB 154-433 6.9e-51 168.0 In-house 6-288 (293) alignment 
Range on Protein: 154-433
Range on HMM: 6-288/293.0
EQRAEMIKKWASAVMMSTPQQLTKEYKAVGNIVSDSECTAFLKF--KDLNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMEN
. ..|..... . .   .  ....||. . .. .| ...|  .   .. ||| ||  .|  |. |      ... || ||...  . |  |. ||||. .
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIvgfvnledhrVYTEYCTEIEIGGKSKDKITHRV-LKVVVKATGQESKLNHYQWASWPDHGMP
|  .||.| .   |. |.||   || | .|| .|  .             . .  .|..  ..... .. |  .. .. . .| |...|.. ||||||.|
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad..........eepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvP

DSCDTALRLLSAVKKD------KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
.. .| |... .|..       |.|...|||||||||||.  .. .. |...    ..    . ||..|.  |||  ||..  .|||..| .|
ektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_PTPRD_pd Subfamily PTPRD 160-449 1.4e-50 167.5 In-house 10-296 (564) alignment 
Range on Protein: 160-449
Range on HMM: 10-296/564.0
IKKWASAVMMSTPQQLTKEYKAVGNIVSDSECTAFLKF-KDLNRYPNIQCWDRGRFTL---AGDEN-FYIHANFVKICTKPERFVCTQGPMENTCTHFWQ
.|..   . ..  .....||| . .  . .  .|  .  |  ||| ||  .|. |  |    |||.  || |.|..  .|.. .. ||||...|.  ||.
lkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWR

MALSLGSTSIIMLCGFVEDGSEKCAKYISDIvGFVNLEDHRVYTEYCTEIeiggkskDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALR
|     |..|.||   .| | .||.||  .  |  . ..  |  | ..|.        ... | .|.  | . .  . ..... ||||||.|.|  . |.
mvweqnsstiVmltkleEkgkvkchkYWPek.gtetygeltVtleeeeel.......adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

LLSAVKK----DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSkglyKRNEQEWTKFKET
|.. |..    |..|.. |||||||||||   |..|.  ... .. ..     .|||.|   |||  ||..  . .||.| .      .| |  ..|..
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac....gntevesenlkqh
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 156-429 4.5e-50 164.9 In-house 10-282 (290) alignment 
Range on Protein: 156-429
Range on HMM: 10-282/290.0
RAEMIKKWASAVMMSTPQQLTKEYK-AVGNI--VSDSECTAFLKFK--DLNRYPNIQCWDRGRFTLA-GDENFYIHANFVKiCTKPeRFVCTQGPMENTC
..| ..|.|| |.  ....|.|||   .     |   |   | |      ||| .. | |. |  |  | .  |.|||.||  .|.  |. |||....| 
qteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk.Glka.mfiltqGalkdtv

THFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNleDHRVYTEYCTEIEiggKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSC
  .|.| |  . . |.|||  .|||  ||..|  .  | |       .|  |.| .   .  ..| ...| |  | .|.| ||.|..  ||||. .. | 
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevl..tfGeitvlcseed...dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst

DTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
 . ||.| ...|   ||. |||||.|||||.. ||  .  | . .. .. |    ||. |. |||   ||.  .. .|..
lallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 170-435 5.9e-49 161.7 In-house 18-284 (288) alignment 
Range on Protein: 170-435
Range on HMM: 18-284/288.0
STPQQLTKEYKAVGNIVSDSECTA--FLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTS
.. .....||... .. .... ||    . .. |||.||  .|  |  | .    ... || |....   | .....||||. .|  .||..     .. 
rnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

IIMLCGFVEDGSEKCAKYISDivgfvnLEDHRVYTEYCTEIEiGGKSKDKITHRVLKVVvkATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK--
|.|| ..||.| .|| .|  |       .... | .   ..  . | ......| | ..   ...| ....||. .|||||.|.|    | ||. ||   
ivmltelveggktkCeeYWPd......adkpknyGsvtvtlv.eskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvan

--DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGL
  | .|.| |||||||||||   .. .| |...  . .| .    ||| ||  |||  ||..  ...|.  . .|.
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgv
subfamily_PTPN12_pd Subfamily PTPN12 175-432 8.5e-46 151.1 In-house 20-279 (290) alignment 
Range on Protein: 175-432
Range on HMM: 20-279/290.0
LTKEYKAVGniVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGD----ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGF
|...|||    |  .|..   . .  ||| .|  .|  | .|  .    .. || |||.|  ... ... .|||. .| . ||.|  .   . ..|.|  
lsekykaek..vysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCre

VEDGSEKCAKYISDIVgfvnlEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKatGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK----KDKKPV
|| |  ||..| .. .     |..  . |.. . |   . .| .. | ||| ..  ... |.. ... .|||||.| | .. |.|...|.    ....|.
velgkkkCerYWpeeg.....eeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPl

IAHCSAGVGRTGTLALIESMIAALRHP---RKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
. |||||||||||.  |. .  .|..     . .| |  . |||.||  |||  ||..  ..|.|.. .
vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_PTPN3_pd Subfamily PTPN3 200-429 9.8e-46 150.9 In-house 44-274 (280) alignment 
Range on Protein: 200-429
Range on HMM: 44-274/280.0
LNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKP----ERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNLEDHR
 ||| .|  .|  | .|   |. || ||.|..         |.. ||||...|.|.||||     |. |.||   ||.|  || .|  .    ... . .
knryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefs

VYteyCTEIeiggKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMIAALR
|.   |..     ... ..  | | .  |.| .| |. . |. .|||||.||. .  |.... |.| .    .||. |||||.|||| | |.|  .| . 
vk...ceke....detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalie

HPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
. .. .. |    .|  ||  |||  || .   ..|. 
aaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 172-430 1.4e-45 150.6 In-house 14-276 (281) alignment 
Range on Protein: 172-430
Range on HMM: 14-276/281.0
PQQLTKEYKAVGNIVSDSECTAFL--KFKDLNRYPNIQCWDRGRFTLA----GDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSII
 . ...||... .|  |.  ||    . .  ||| ||  .| .| ...      .. || ||||.  ....... ||||. .....|||| ..   . |.
naGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaiv

MLCGFVEDGSEKCAKYISDIVGFVNLEDHRVYTeycteieIGGKSKDKITHRVLKVvVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAV-----K
|.   .| |  || .|  |    ... | .| .       .  ..| .  .|..|.  . .|.. .... .. .|||||.|..    |   ..|     |
mvtreieagklkChrYWPddnselkygdvtvks.......taeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltek

KDKKPVIAHCSAGVGRTGTLALIESMIAAL-RHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
| | |.. |||||||||||   .. .. |. .. .. .||.    |||.|   |||  || .  . ||. |
ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN13_pd Subfamily PTPN13 173-430 1e-44 147.9 In-house 11-269 (273) alignment 
Range on Protein: 173-430
Range on HMM: 11-269/273.0
QQLTKEYKAVGNIVSDSECTAFLK--FKDLNRYPNIQCWDRGRFTLAGDENfYIHANFVKICTKPERF--VCTQGPMENTCTHFWQMALSLGSTSIIMLC
|| ..|.| . .. .  .|.   |   || ||| |.  .|. | .| .. . || |...|.    ...  . .|||. .|.. ||||     .. |.|. 
qqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

GFVEDGSEKCAKYISDIVGFVNLEDHRVYTEYcteieIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK---KDKKP
  .|.|  || .|  .. .       |.  |      .. . .|  . | |.|  ...|.  .. | ....|||||.| | .  |.... |.   .|. |
lekekgkvkchrywPesknkklkvsnrlevel.....lkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagP

VIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
.. |||||.||.|||  |. ..  . . .. .||.    ||. |   |||  ||..  . .|| |
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_PTPN1_pd Subfamily PTPN1 194-428 1.8e-44 146.6 In-house 29-269 (290) alignment 
Range on Protein: 194-428
Range on HMM: 29-269/290.0
FLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYIS--DIVGFVNL
. . ..|||| ... .|  | .|  ..| || |..|..     ... ||||. ||..|||||     | ...||  .|| .. |||.|    . .  . |
lpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekelll

EDHRVYTEYCTEieiggKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK------KDKKPVIAHCSAGVGRTGTLALIES
|| ..  .. .|     ..|.. | |.|..  . | .  .. |. . .||| |.|.|  . |..|  |.      .|. |.. |||||.||.||..|...
edtklkvklise.....erksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt

MIAALRHPRK---QNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
... . .  .    ..|. .. ||| |   .||  |  ..   .||
clvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 166-428 5.2e-44 145.6 In-house 15-281 (305) alignment 
Range on Protein: 166-428
Range on HMM: 15-281/305.0
AVMMSTPQQLTKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDEN----FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGS
 . . . ..| ..||.. .  .  . .   . |  ||. .|.  |  |. |. .|.     || |..|.   . .... .|||..|| . ||.. .    
earvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekv

TSIIMLCGFVEDGSEKCAKYISDIVGfvnleDHRVYTEYCTEIEIGgKSKDKITHRVLKVVVKATGQES-KLNHYQWASWPDHGMPDSCDTALRLLSAVK
..|.||.. ||.| .|| .|  . ..     ... . |.  |..   |.    . | ||. .. . .||  . .||  .|||||.|..  . |.|.  |.
stivmltklveggkdkCrqYWpeskt.....ekkefgefsvelkse.ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvq

KD----KK-PVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
||    |. |.. ||||||||||.   .. ..  |..    .| .    ||. |   |||  |||.    . |
kdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 154-432 1.1e-43 144.6 In-house 8-292 (298) alignment 
Range on Protein: 154-432
Range on HMM: 8-292/298.0
EQRAEMIKKWASAVMMSTPQQLTKEYKAVGNIVS-----DSECTAFLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKICTKPERFVCTQGP
|.  ....| |.     .  ....|.. . .. |      .| .   . |. |||..|  .|  |  |      .|  || | |..  .. . |. ||.|
edlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaP

MENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvnlEDHRVYTEYCTEIEIgGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHG
...| . ||.|     ...|.||   .| .  |. ||  |       | .. | |   ..    ... ... | |||  | . .| .. . .. ||||.|
ltetvedFWrmvteedigtiVmltnleeldktkyhkywPd.......egketygeitvslls.keefadlivrklkvskkkeekerevrqlhftsWpdkg

MPDSCDTALRLLSAVKKD-----KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
.|    . | ||. |..      .|||| .|||||||.||   |.|..  ... ..  | .    |||.|. .|||  |||.    |||.| |
vpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 200-433 2.5e-43 142.8 In-house 58-292 (305) alignment 
Range on Protein: 200-433
Range on HMM: 58-292/305.0
LNRYPNIQCWDRGRFTLAGDE-NFYIHANFVKICTKPE-RFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGfvnlEDHRVY
 ||| .. | |.    |.      |||||.|     || ||.|.|||...|  .|| | .      |.|||  || |  |||.|     |    | . . 
knryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg....eklelk

TEYCTEIEIGGKSKDK---ITHRVLKVVVkATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPR
.    |   | |  ..   |   .|..   . .|.  . | ||. ||| |.|    |.| ||||..  | |.. |||||.|||||.  || ..  .   .
sgivvenvsgskpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenk

KQN-VKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
.   . .    || .|| |.|.  ||..  | .|...  |
pcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 188-430 4.5e-43 142.2 In-house 11-264 (270) alignment 
Range on Protein: 188-430
Range on HMM: 11-264/270.0
DSECTAFLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVK-ICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYI
.|.  .. . | |||| .|    . | .|.     ..  || ||.|. .  .........||...| ..||.| ..  .|.|.|. |..|.| .||..| 
esdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYW

SDivgfvnlEDHRVYTEYCTEIEIGGKSKDKI-THRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCD------TALRLLSAVK-----KDK-KPVIAH
.        | ..  .    .|..   |. |   ... .. .. .|.| .| |... .|||||.| . |        |..| ||.     .|| .|.. |
pa.......epkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvH

CSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
||||||||||| ... .. .| . .| .|      |||||   ||.  || .. . |.|. 
csaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
0041856 (Phosphotyrosine protein) phosphatases II 199-433 4.6e-42 139.0 In-house 3-174 (182) alignment 
Range on Protein: 199-433
Range on HMM: 3-174/182.0
DLNRYPNIQCWDRGRftlagdENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCgfvedgsekCAKYISdivgfvnledhrvyt
|.|||..| ..|..|       . ||.||..  . .. ||..||||. .|. .|..|  .|| |.|..|.         .  |                 
dknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...............

eycteieiggkskdkithrvlkvvvkaTGQESKLNHYQWASWPDHGMPDsCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAAlrhprKQNV
                           .  |    .|.. .||||| ||  |..|... .|.....||. ||||||||||||...  |.       . ..
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsl

KDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
 . . |.|. |  .|.|  ||..  ...||.|. |
eeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 169-443 9.5e-42 138.2 In-house 16-293 (318) alignment 
Range on Protein: 169-443
Range on HMM: 16-293/318.0
MSTPQQLTKEYKAV-GNIVSDSECTAFLK-FKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGST
.|   .|..||...  .  . ..  .  .  |  ||| ||  .|. |  |   |      || ||..   .. . .. .|.|. .|.. ||.|    .|.
esGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa

SIIMLCGFVEDGSEKCAKYISDivgfvnlEDHRVYTEYCTEIEIGGKSkDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK-
 |.||   .| | .|...|  .       .. | | .   |..   .. .. . | .||  . . .. .   |...||||.|.|.|  . | |.  |.| 
vivmltqeeergkakvhryWPs.......kgsrsygklvvelkeevel.sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvska

----DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQEW
    ...|.. ||||||||||.   .....  ...    .| .    ||. |   |||  ||..    .||.| |  ..   ..  
qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 162-432 1.2e-41 137.8 In-house 12-285 (319) alignment 
Range on Protein: 162-432
Range on HMM: 12-285/319.0
KWASAVMMSTPQQLTKEYKAVGNIVSDSECTA-FLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMA
.   |.  .. ..| ||.| . . |.|.  .|   . |. |||.||  .|| | .|.     ..  || |.|.    . |.|. ||.|.|||   ||.| 
erlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmv

LSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvnlEDHRVYTEYCTEIEIGGKSKDKItHRVLKVVVKATGQE-SKLNHYQWASWPDHGMPDSCDTALRL
   .|  ..||.. || .  |. || ..       |.. .| ..  ..|   . .| |  | ||.  |..  |  .. |.|. .||||..|..  . | |
Weeessivvmltklveklkvklkkywpe.......enfeeyGrlivtleeeeeledyi.irklklnkkssevetRevkhfqyteWpdhdvPekatslldl

LSAVKK-----DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
|  ..|     ...|.. |||||||||||   .. |.  ...    .|      ||  |   ||.  || .    .||.. .
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 198-434 4.8e-41 135.6 In-house 10-246 (250) alignment 
Range on Protein: 198-434
Range on HMM: 10-246/250.0
KDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEkCAKYISdivgfvnLED
|. ||| .|  .|  |  |  ..      || | |..  .. . |. ||||...|  .||.| |   |..|.||  ..| . . . .|.         | 
keknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.......vek

HRVYTEYCTEIEIGGKsKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK-----DKKPVIAHCSAGVGRTGTLALIESMIA
 . | .   ..    . .  .|.|.||.  .   .|  . .... .||| |.|.   ..| ||. |..     ...||| .|||||||.|.   |.... 
aekyGdvtvsllskee.fadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

ALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKG
 |.. .. .| .    ||||| ..|..  |||.  . .|..| | .
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 190-419 5.3e-40 132.0 In-house 44-270 (301) alignment 
Range on Protein: 190-419
Range on HMM: 44-270/301.0
ECTAFLKfKDLNRYPNIQCWDRGRFTLAGD-ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIV-G
|  |.|. || .|||.. |       .  | .   ||||...   .|.||..||||..||.  || |        |.||. .||.  |||..|..  .  
esyaylp.kdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkise

FVNLEDHRVYTEYCTEIeiggkSKDKITHRVLKVVVKATGQES-KLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESM
 .... ... ..    |      ..||..| |.|.  .   ..  . |||...|.|.|.| |      |.  ||| .||.. |||||.||. ..   | .
kldigrfkikiknkeli.....lnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteyl

IAALRHPRKQNVKDSFVLLRKDRARSVQTFPQY
  ..   .. ......  ||..| ..|||  | 
areveadptieltealkhlrehrwngvqtnsql
subfamily_Ptp69D_pd Subfamily Ptp69D 171-430 1.4e-39 131.1 In-house 20-286 (307) alignment 
Range on Protein: 171-430
Range on HMM: 20-286/307.0
TPQQLTKEYKAVGNIVSDSECTAFLKFKD--LNRYPNIQCWDRGRFTLA----GDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSI
| . |.|||. . .  .| ....  |  .   |||..|. .|. |  |.     ..  || |.|.|   . ..|.. |.|.|.|   ||.|     .| |
tdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtli

IMLCGFVEDGSEKCAKYIS--DIVGFVnledhRVYTEYCTEieiggKSKDKITHRVLKVVVK-----ATGQESKLNHYQWASWPDHGMPDSCDTALRLLS
.||    |   .||||| .  |.| .       .  ..  |     ..... ..| |.|  |        .. |.  |.. .|.|  .|... . |.|..
vmlsnlteknrkkcakYWpiedevqyg.....dilvklvse.....ekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklie

AV----KKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
 |    |... |.. ||||||||.|..  ..|..  |.   | .. .    ||..|   || . |||.  | .|.. 
qvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 172-430 2.7e-39 129.9 In-house 4-268 (274) alignment 
Range on Protein: 172-430
Range on HMM: 4-268/274.0
PQQLTKEYKAVGNIVsDSECTAFLKFKDLNRYPNIQCWDRGRFTLA---GDE--NFYIHANFVKICT-KPERFVCTQGPMENTCTHFWQMALSLGSTSII
...|.||.  .   . | | .   . .  ||| .|   .. | .|    ...    || ||..|    . . .| ||||. || . ||.|     .. |.
fkdlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MLCGFVEDGSEKCAKYISdivgfvNLEDHRVYTEYcTEIEIGGKS-KDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK-
||  . |   .|||.|        . || ..  .| ...||  .. ...  ..| |.|.| . .| .. || ...||||  ||. .| |.|.  |.... 
mltklkeaneqkCavyfP......daedyeisery.gdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesre

----K--PVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
    |  ||. |||||.||||    |.  .  ||.  . .|    . || ||   |||  || .  | . ..|
eenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_PTPRA_pd Subfamily PTPRA 171-433 3.8e-39 129.5 In-house 30-299 (330) alignment 
Range on Protein: 171-433
Range on HMM: 30-299/330.0
TPQQLTKEYKAVGN--IVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLA---GDE-NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSI
  ... .|..|.    | .  | ..  . |. ||..||  .|  |  |.   | |   || | |..   . ..|. .||| |.|   ||.|     |..|
dnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksati

IMLCGFVEDGSEKCAKYISDiVGFVNLEDHRVYTEYCTEIEIGGKSKDKIThRVLKVVvkATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK-
.||  . |   ||||.|  |  | |   . ||  | .|...     |  .. .. .       ..  .. . . |||| |.|      |.|| .||| . 
vmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvq.qlpdat..rekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

---KPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF-LYSK
    |.. |||||||||||.  ...... ..  || .| .    ||. |.. |||  ||..  . .||. ||  
qsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygd
subfamily_PTPN14_pd Subfamily PTPN14 176-430 4.7e-39 129.2 In-house 26-296 (300) alignment 
Range on Protein: 176-430
Range on HMM: 26-296/300.0
TKEYKAVGNIVSDSE--CTAFLKFKDLNRYPNIQCWDRGRFTLAGD---ENFYIHANFVKI--CTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLC
 .||  . .   |..  ...  . .. ||....  ..  |  |.     .. || |  .|.  ..|   .. .|||.|.|.. ||||    | . |.|| 
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

GFVEDGSEKCAKYISDI---VGFVNLEDHRVYTEYCTeieiggKSKDKIThRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK-----
   ||| ||. ||. .       |. . ..|.|.. .      .|.  || . ||.    ...| .. | |.. |||||.|.  .. |  |  |.     
eeeedgkeksfkyfPkleskkktvefgkfkvttkfse......dsdsvit.tglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

--------KDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
        . | ||. |||||||||| | | . .||.| | .. ..| ..  ||. |   |||. || .  . ....|
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_PTPN6_pd Subfamily PTPN6 194-432 8.3e-39 128.4 In-house 51-299 (306) alignment 
Range on Protein: 194-432
Range on HMM: 51-299/306.0
FLKFKDLNRYPNIQCWDRGRFTLAGD---ENFYIHANFVK--ICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVgf
  . |  ||| ||  .|  | .|. .   .. || ||..|  . .. .... ||| .|.| . ||.|..   |. |.|.   || | ||||.|  |    
kpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdee..

vNLEDhrvYTEYCTEiEIGGKSKDKITHRVLKVV-VKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKD--------KKPVIAHCSAGVGRTGT
 . |.   | ..  . ..  ||... . | |.|  .|  ..| .. .|.. ||||||.| . .. | .|. |..         . |.. |||||.|||||
.ekee...yGkisvt.nvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGt

LALIESMIAALRHP---RKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
. .|. ..  ...     . .....  ..|. |   |||  || .  . . ... .
fiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN23_pd Subfamily PTPN23 186-428 9.5e-39 127.9 In-house 32-278 (288) alignment 
Range on Protein: 186-428
Range on HMM: 32-278/288.0
VSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKI-CTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISD
  .  ...  .. . ||. .|  .|. | .| | .. || | |||   .    |..||.|...|   ||.|  .  |  |.||    | | .|...|   
arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe

IVGFVNLEDHrvyteYCTEIEIgGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK--------DKKPVIAHCSAGVGR
  |  .  ..     .   ..   .. ..  .||||. .. . .  .. | |. |||..|.|.| .| |..| .|..         |.|.. ||||||||
dkgetvkfgd.....lsvtlks.vretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgR

TGTLALIESMIAALR-HPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
||..||. . ...|. ..   .. . .  ||..|  .||.  |.  ..  |||
tgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_PTPRG_pd Subfamily PTPRG 166-435 4.9e-38 125.7 In-house 12-292 (563) alignment 
Range on Protein: 166-435
Range on HMM: 12-292/563.0
AVMMSTPQQLTKEYKAVGNIVSDS--ECT--AFLKFKDLNRYPNIQCWDRGRFTL---AGDEN--FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMA
..  .. . ...|..|. . . ..  ...     . |  ||| ||   || | .|   .| ..   || ||...   | . |. ||||...|.  ||.| 
slhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmi

LSLGSTSIIMLCGFVEDGSEKCAKYISDiVGFVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKaTGQESKLNHYQWASWPDHGMPDSCDTALRLL
    .. |.|.  .||.| .||  |     . ....  .|  .    . .  . . .| .. ||   . . .| .  .|....||||| |..    |   
WeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkq.cdteklvrqyhytkWPdhgvPehslpvLifv

S----AVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGL
     | |..  |.. |||||||||||.  .....  ...  . || .    .|  |   |||  ||..    .|| . ||  
kkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
0051429 (Phosphotyrosine protein) phosphatases II 223-432 5e-38 126.6 In-house 6-227 (272) alignment 
Range on Protein: 223-432
Range on HMM: 6-227/272.0
YIHANFVKICTK---PERFVCTQGPMENTCTHFWQMaLSLGSTSIIMLCGFVEDGSEKCAKYIS-----------DIVGFVNLEDHRVYTEYCTEIEIgg
||.|..|.  ..   | |. ...||...|. .||..  .|| ..|..|.. .| |..|| .|.            | . .... ..||.. ...  .   
yiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld..

kskdkITHRVLKVVVK-ATGQESKLNHYQWASWPDHGMPDSCdtALRLLSAVKKdKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQN--------VK
     ...|.| .. .  .|.  .. |... .||||| |..    |.||... . ..||. |||||..||||....  ... . .    .        . 
.....yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

DSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
.    ||. |. .|||  ||.. ....||.|.|
eaveelraqrpgavqteeqylflyeallellrs
subfamily_PTPRK_pd Subfamily PTPRK 197-429 3.9e-37 122.7 In-house 43-276 (314) alignment 
Range on Protein: 197-429
Range on HMM: 43-276/314.0
FKDLNRYPNIQCWDRGRFTL---AGD-ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvnle
 .. ||. .|   || | .|    || .. || |...   ..|. |. ||||...| . ||.. .  ...||.||  .|| |  || ||  .        
nreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe........

DHRVYTEYCTEIeIGGKSKDKITHRVLKVVV--KATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESM
| .|| .   |. .  . . .. .|...|    ..  .  .....|. .||||..| |  . |.|.  ||| .     ... ||||| |||||   |...
dtevygdikvel.vetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv

IAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
.  ... .  .|      ||. .   |.|  ||..    .|| 
ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
0043147 (Phosphotyrosine protein) phosphatases II 219-423 8.4e-37 121.9 In-house 3-154 (172) alignment 
Range on Protein: 219-423
Range on HMM: 3-154/172.0
DENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFvedgsekcakyisdivgfvnledhrvyteycteieiggkskdkithrv
. . ||.|...... .| ||..||||. ||. .||.|  .|| | |..|...                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

lkvVVKATGQESKLNHYQWASWPDHGMPdSCDTALRLLSAVKK-----DKKPVIAHCSAGVGRTGTLALIESMIaalrhpRKQNVKDSFVLLRKDRARSV
   .. ... |    .|.. .||||| | . .  |..|. ...     ...||. ||||||||||||...  |.      .. .. . . |.|. |  .|
...lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgav

QTFPQYVYAL
|.. || . .
qnpsqyrfly
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 178-430 3.2e-36 119.4 In-house 16-269 (281) alignment 
Range on Protein: 178-430
Range on HMM: 16-269/281.0
EYKAVGNIVSDSECTAFLKF--KDLNRYPNIQCWDRGRFTLAG-----DENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGF
|.  .        ||.| .   .  ||| || | |  |  |       .   |||||...       .. |||| ..| . ||.|     .|.|.||| |
efsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqf

VEDGSEKCAKYISDIVgFVNLEDHRVYTEYcteiEIGGKSKDKITHRVlkvVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHC
.|   ||||.|.      . |.  ..  .|    |     |  .| |.    .   |.   . |. |  |||  .|.| .  |..|  ..    | . ||
letnrekcaeyfprna.hcclqfdklsvsy....edstvnkslvttrl...nlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihc

SAGVGRTGTLALIESMIAAL-RHPRKQNVKDSFVLLR-KDRARSVQTFPQYVYALRCVLEFL
||||||.|||  .|  . ..  |    ..|.    ||   || ||||. ||.   . .|.| 
sagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 173-432 4.1e-36 119.9 In-house 34-294 (319) alignment 
Range on Protein: 173-432
Range on HMM: 34-294/319.0
QQLTKEYKAVGNIV---SDSECTAFLKFKDLNRYPNIQCWDRGRFTL---AGDEN-FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSII
..|  |.... ..    .| . .   . || ||. ||  .|. .  |    | |   || | ||.   ...... .|||..||   ||.|     ...|.
tklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstiv

MLCgfvedgSEKCAKYISDiVGFVNLEDHRVYTEYCTEIEIggkskdkITHRVLKVVVK--ATGQeSKLNHYQWASWPDHGMPDSCDTALRLLSAV----
.|        .||..|     . .. |   |  .  .| .         . | ...  .   ...  |.. . .  |||.|.||.    .||.  |    
llt......kdkcsqywpl.kivikeerfkvkvdsveetae.......yvvrdielsedgkekdi.rkitqfhflGwpdvGvpdypsdlmrlvkkvrhlt

--KKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE-FLYS
  ........ ||||||||||.   .. ..  ... .. .| .    ||..| . || . || .    .|| .|..
skenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 196-433 9.9e-36 118.4 In-house 51-287 (297) alignment 
Range on Protein: 196-433
Range on HMM: 51-287/297.0
KFkDLNRYPNIQCWDRGRFTLAGDENF----YIHANFVKICTKpeRFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFvEDGSEKCAKYISDiVGFVNL
.| . .|| ||   |. | .||  ..     |. | |||   .  |...|| ||..|   ||.| |    . |.||    ... .|||.| ||  | ...
nf.eksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlndd.nerdkkcaryWsd.kgvttf

EDHRVYTEYCTEIEiGGkskdkiTHRVLKVVVKATGQESKLNHYQWASWPDHGMPD--SCDTALRLLSAVKKDK-----KPVIAHCSAGVGRTGTLALIE
 |  | ..  .| | |.       .| |.|   .. ..  .. ||. .|||. ..   |  . | |.| |.||       |.. ||.||||||| |  |.
Gdvsvvllsvsere.Gf......ikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltid

SMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
|..|  ..  . .. .    ||..|   |||  || .    |||.|.|.
svvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 189-432 2.5e-35 117.3 In-house 17-258 (284) alignment 
Range on Protein: 189-432
Range on HMM: 17-258/284.0
SECTAFLKFKDLNRYPNIQCWDRGRFTL---AGDEN-FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCgfvedgSEKCAKYISD
 . .   . || ||. .|  .|. .  |    | |   || | |..   ...... ||||..||   ||.|     ...|..|        .||..|   
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

iVGFVNLEDHRVYTEYCTEIEIggkskdkITHRVLKVVVKATGQ-ESKLNHYQWASWPDHGMPDSCDTALRLLSAV------KKDKKPVIAHCSAGVGRT
  . .. |  .|  .  .| |         . | ...  ..  .   |.. . .  |||.|.||.    .||.  |      ........ |||||||||
.kivikeerfkvkvdsveesee.......yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE-FLYS
|.   .. ..  ... .. .| .    ||..| . || . || .    .|| .|..
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 197-435 4.8e-35 115.9 In-house 47-283 (287) alignment 
Range on Protein: 197-435
Range on HMM: 47-283/287.0
FKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvnlEDHRV
 ||.||. .|   |  |  | | .. || | |..   .  .|. ...|| ||   ||..      | |.|||   |.  |.| .| ..       |.  |
nkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe.......eksvv

YTEYCTEIEIGGkSKDKITHRVLKVVVKA-TGQESKLNHYQWASWPDHG-MPDScDTALRLL-SAV----KKDKKPVIAHCSAGVGRTGTLALIESMIaa
. ||  |.      ... . | |.|  |  .|.. ... || ..|...| ...   | | ..   .    |. . ... |||..|||....  ..  |  
lGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtep.qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaatti..

lRHPRKQNVKDSFVLLR---KDRARSVQTFPQYVYALRCVLEFLYSKGL
 .. ... | | | .|.     .  ||||  || .    |||.| |  .
.nkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 180-441 9.7e-35 114.9 In-house 18-281 (285) alignment 
Range on Protein: 180-441
Range on HMM: 18-281/285.0
KAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPE-RFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKC
|  | .  .   ||.    ||||| ...| .  |  |   .  ||||.....  | .  .. ||||. .| . ||.|      . ..||| ..| | |||
kikgymppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekc

AKYISDIVG-FVNLEDHRVYTEYCTEIEIGGKSKDKIThrVLkVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK---DKKPVIAHCSAGV
| |  . .|  |..  . .    | |  | |   . .|  |.     |. .   .|| |   |||.  |. .   . |   |||    .||.  ||||||
alyypeklgevvkfgkyeitlteckeeaiagtilnalt..vi.ntedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagv

GRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKRNEQ
||| |.  |.     .    . .. |    .|  | ..||.. |...    ..|..  .|. .|  |
grtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvvertgq
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 175-430 2.1e-34 113.5 In-house 29-290 (310) alignment 
Range on Protein: 175-430
Range on HMM: 29-290/310.0
LTKEYKAVGNIvSDS--ECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE---NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCG
|.|.|. .     ||     |. |.   ||| .. | |  |  |  |    . |||||.||     . |.|.|||.. |   ||.| .   . ||..|| 
lvkqyrkldak.qdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck

FVEDGSEKCAKYISDIVGFVNLEDHRV--YTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDS-CDTA-LRLLSAVKKdkKP
 .|.|  ||  |   .         ||  ..|   |.||   .   .   |      |  .| ...  .|  ||| |.||  | |   |||. |..   |
vgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh..gp

VIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
.. |||||..|..... ..  |  |..  | ....    |.|.||  .||  ||..  |  . | 
cvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 197-431 2.1e-34 113.5 In-house 44-277 (515) alignment 
Range on Protein: 197-431
Range on HMM: 44-277/515.0
FKDlNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVG----F
||  ||| ||  .|. |  |       .. |. | ...       ....||| . .   ||.. |    | |.|.    |.   ||.||  |. |    |
fkk.nryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

VNLEDHRVYTEYCTeieiggkskdKITHRVLKVVvKATGqESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIE
 ... . | .| ||            . | |.|. |       .  ...  |||.|.|  . . |.|. .|| |.     |.| |||||||||| .  |.
Gsikvelvsleact..........ggikrkltvl.kgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisid

SMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
|..|  .  |  .| .    .|..|   |||  || .    ||| |.
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 200-431 2.9e-34 113.3 In-house 47-278 (315) alignment 
Range on Protein: 200-431
Range on HMM: 47-278/315.0
LNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISD----IVGFVNL
 ||| ||  .|. |  |       .. || | ..|   . . ....||| . .   ||.| |    |.|.|.    |.   ||..|  |     | | ..
knryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsi

EDHRVYTEYCTeieiggkskdKITHRVLkvVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKK----PVIAHCSAGVGRTGTLALIESMI
. . . .| .|            ..| |  |.. . .  ..  .|.  |||.| .    . |.|. .|| |..    ... |||||||||| .  |....
kvellsleadt..........dgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

AALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
| ... |  .| .    ||..|   |||  .| .    ||| |.
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 200-428 3.5e-34 113.1 In-house 6-237 (237) alignment 
Range on Protein: 200-428
Range on HMM: 6-237/237.0
LNRYPNIQCWDRGRFTLA--GDENFYIHANFVKI-CTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIvgfvnlEDHRV
 ||| ||...|  |  |   | .  || |...|     | .....|||.|..|  ||||      . |.|| |..|   .|| ||  .       .. . 
knrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst......dqpaa

YTEYCTEIEIGGKSKDkITHRVLKVVVKATGQESKLNH-YQWASWPDHGMPDSCDTALRLLSAV-KK-----DKKPVIAHCSAGVGRTGTLALIESMIAA
|  .   .    .  |  | | | .... | .| .| | ||..||||.|.|. . . ||.   . ..     .  | | |||||||||| . .|..|.  
ygvltvslkkkeefsd.ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

LRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
 .  .  .. .    . .||   .||  |||.  . .||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0046846 (Phosphotyrosine protein) phosphatases II 221-429 3.7e-34 113.4 In-house 12-172 (176) alignment 
Range on Protein: 221-429
Range on HMM: 12-172/176.0
NFYIHANFVKICtkpeRFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNledhrvyteycteieiggkskdkithrvlk
  ||.||..  .    |...||||...|. .|..| ..|| | ...|.  || |. ||. | ... ..                                
ldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

vvvkatgqesklnHYQWASWPDHGMPDScD---TALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIEsmiaALRHPRKQNVKDSFVLLRKDRA-RSVQTF
             .|..  ||||| ||. .   ..|...  . |...||. |||||.||||||...      |.. .  .| . . |.|. |  ..|||.
.............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

PQYVYALRCVLEF
 || .  ...|..
eQyrflyefelll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 186-434 1e-33 111.5 In-house 33-287 (290) alignment 
Range on Protein: 186-434
Range on HMM: 33-287/290.0
VSDSECTA--FLKFKDLNRYPNIQCWDRGRFTLA-----GD-ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEK
 |. . |     . | |||. ||   |  | ||       | .| ||.| ..|   . .... ||||..||  .||..     .| |.||.  .|.|..|
esehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvk

CAKYISDivgfvnlEDHRVYTEYCTEIeIGGKSKDKITHRVLKVVVKAT-GQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKK-----DKKPVIAHCS
| .| .|       .| . | |.  .. .  .. .....| |.|  | . |..... .||  .|...|      | | ... . |      ..... |||
CqqYWpd.......sdtkaygefsikl.lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCS

AGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKG
..|||....  ..  |   .     .| .    .|  .  ||||  || .  . ||. |.|  
dtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
0049260 (Phosphotyrosine protein) phosphatases II 229-422 1.3e-33 111.2 In-house 2-142 (152) alignment 
Range on Protein: 229-422
Range on HMM: 2-142/152.0
VKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYIsdivgfvnledhrvyteycteieiggkskdkithrvlkvvvkatgq
.... .| .|..||||..||. .||.|  .|| | |.||. ..|.| .||..||                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

esklnHYQWASWPDHGMPDSCDTALRLLSAV----KKDKKPVIAHCSAGVGRTGTLALIESMIaalrhpRKQNVKDSFVLLRKDRARSVQTFPQYVYA
     .|..  ||||| ||. .  | || ..    .....||. ||||||||||||...  |.      .. .... . |.|. |  .|... |. . 
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl
0036282 (Phosphotyrosine protein) phosphatases II 222-422 6.8e-33 109.2 In-house 3-162 (174) alignment 
Range on Protein: 222-422
Range on HMM: 3-162/174.0
FYIHANFVKICTKPERFVCTQGPMEntcthFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvnledhrvyteycteieiggkskdkithrvlkv
 ||.|.....   ..|....|||..     ||.|  .||.|...||.  .|.|..||  | ..                                     
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

vvKATGQESKLNHYQWASWPDHGMPDSCDtALRLLSAVKKD-----KKPVIAHCSAGVGRTGTLALIESMIAALRhPRKQNVKDSFVLLRKDRARSVQTF
  . .  |    .|..  |||||.||.    |.....|..      ..||. ||||||||||||...  |.  |. .. ... | .  ||. | ..|||.
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

PQYVYA
 || . 
sQyrfl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 196-429 3.1e-32 106.7 In-house 48-278 (315) alignment 
Range on Protein: 196-429
Range on HMM: 48-278/315.0
KFKDLNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIvgfvnl
. |. ||| ||   |. |  |      ..  |. |||..  .|..|....|||  ..   ||..      . |.|| . ||.  .|. ||  |       
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk......

edHRVYTEYcTEIEIGGKSKDKITHRVLKVVVKATGQEskLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMI
  . .| .. |   .  . ....| | | ||..   .|  .  ....|||| |.| .. . . |   ||. .     ... |||||||||||.  .....
..kviyGki.tvtrkseevnteytvrtlsvvfgdnire..vvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavl

AALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
  .   .  .| .    .|. | . ||.  || .    .|| 
dqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
0049772 (Phosphotyrosine protein) phosphatases II 194-431 3.5e-30 101.2 In-house 43-281 (314) alignment 
Range on Protein: 194-431
Range on HMM: 43-281/314.0
FLKFKDLNRYPNIQCWDrGRFTLaGD----ENFYIHANFVKICtkpERFVCTQGPMENTCTHF----------WQMAL--SLGSTSIIM-----------
... .| |||..|...|  |  | .        ||.|..|. .    .|..||||.|.|.  |          |.| |   | .  | |           
lflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LCGFVEDGSEKCAKYISDIVgfvnledhrvyteycteieI-------GgkskdkithrvlkvvvkatgqESKLNHYQWASWPDHGMPdSC
          |... . |.| .|... ..                                                  |    .| .  .||.. | . 
rLdaAlgKtpllildgngneptaadlellk...................eelydpelf.....................erlgikylripvpDgsap.ll

DTALRLLSAVKK--DKKPVIAHCSAGVGRTGTLALIESMIAALrhprKQNVKDSFVLLRKDRA-----RSVQTFPQYVYALRCVLEFLY
.  ...| ....  ...||. ||.||.|||||....  .. .|    . .... .  .|. |      ...... ||.. |...||.| 
edfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_PTPN9_pd Subfamily PTPN9 161-361 1.5e-29 98.0 In-house 4-204 (297) alignment 
Range on Protein: 161-361
Range on HMM: 4-204/297.0
KKWASAVMMSTPQQLTKEYKAVGNIVSDSECTA--FLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQ
..  . |     . |.|||... |     . .|         ||| .. |.|. | .||     ..  ||.||||    ... |. ||||...|.. ||.
eelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWr

MALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvNLEDHRVYTEYCTEiEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALR
|        |.|   .|| |  ||..|  .     . |.   ....  . ..  ..... ..|||..    |... |. |.|  ||||.|.|.|. . | 
mvWeqevlvivmttrvvergrlkcgqyWpl.....eeessaefgdlsvs.nveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslld

LLSAVKK
.|..|..
vlekvre
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 175-430 1.1e-28 94.9 In-house 22-279 (439) alignment 
Range on Protein: 175-430
Range on HMM: 22-279/439.0
LTKEYKAVGNIVSDSECTAFLKFKD----LNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIM
...... .. .  | .| | |  ..     ||| ..  .| .| ||          || ||..|   ... .. |||| ..|. .||.. .   .. |.|
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivm

LCGFVEDGSekcakyisdivgFVNLEDHRVYTEYCTEIEIGGKsKDKITHRVLKVVVK--ATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAV-----
|. .||               .   ... .| . .  ..   .   . . | .||. .   | .|  . .... .|||. .|  .   | .| |.     
ltnlvesyk............ywpsdaevcygdiavrvdrnie.lpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsand

KKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL
|..  ||. |||||||||||.  ..  .  |.   | ..|    .|||.| . ||.. |||.   .||| .
keeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 170-430 1.3e-27 91.3 In-house 12-293 (301) alignment 
Range on Protein: 170-430
Range on HMM: 12-293/301.0
STPQQLTKEYKAVGNIVsDSECTAFL--KFKDLNRYPNIQCWDRGRFTLAGDEN------FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGS
   ... ..||.. .   | .||  |  . | |||. ||. .|  |..|.  .|       || |.... ... ..|. .||||..| . ||.. .    
khsnkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

TSIIMLCGFVEDGSEKCAKYISD-------IVGF-VNLEDHRVYTEYCT---EIEIGGKSKDKITHRVLKVVVKAtgQESKLNHYQWASWPDHGMPDSCD
.||.|...  |.  .|| .| ..        . | | | .. || ..      . |   |... ..| .||  .   .  ..  .| ..||..|.     
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvrepr

TALRLLSAV-----KKDKKPVIAHCSAGVGRTGTLAlieSMIAALRHPRKQNVKDSFVL---LRKDRARSVQTFPQYVYALRCVLEFL
| |. .  |     | .. ||. |||..|.|.|.     |.  .|   . . | | | .   .|. .   |.|  ||.     . ..|
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYc...svsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 198-428 1.6e-27 91.2 In-house 8-238 (239) alignment 
Range on Protein: 198-428
Range on HMM: 8-238/239.0
KDLNRYPNIQCWDRGRFTLAGD----ENFYIHANFVKI-CTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVG-FVNL
|  ||| ||  .|. |  |        . || |....     |. ...||| .| ..  ||.|        |.|| |..|   .|| .|  |    ..||
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

edhRVyTEYCTEIeiggkSKDKITHRVLKVVVKATgQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMi
   || |   ||.       | | . ..   |  | .|  . .|... |||.|.|. . . | |   . ||     .| . ||||||||||.. .|..| 
...rv.tlrktev.....fadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam.

aaLRHPRKQNVKDSF---VLLRKDRARSVQTFPQYVYALRCVLE
  ||. .||.  | |     .|.|| . |||  |||.   .|||
..lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 198-428 2e-27 90.9 In-house 9-239 (239) alignment 
Range on Protein: 198-428
Range on HMM: 9-239/239.0
KDLNRYPNIQCWDRGRFTLAGD----ENFYIHANFVKI-CTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVG-FVNL
|  ||| ||  .|. |  |        . || |....     |. ...||| .| ..  ||.|        |.|| |..|   .|| .|  |    ..||
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

edhRVyTEYCTEIeiggkSKDKITHRVLKVVVKATgQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMi
   || |   ||.       | | . ..   |  | .|  . .|... |||.|.|. . . | |   . ||     .| . ||||||||||.. .|..| 
...rv.tlrktev.....fadyiirtfvmsqvgqt.eeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam.

aaLRHPRKQNVKDSF---VLLRKDRARSVQTFPQYVYALRCVLE
  ||. .||.  | |     .|.|| . |||  |||.   .|||
..lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 197-432 2.1e-27 91.1 In-house 48-290 (325) alignment 
Range on Protein: 197-432
Range on HMM: 48-290/325.0
FKDLNRYPNIQCWDRGRFTLAGD----ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGsTSIIMLCGFVEDGSEKCAKYISDIVGfvnle
 |. ||..|.   |. |  |       .  || |....   | . |. .| |. .|   .|...|    .|....   .. | ..||.|  . .|     
nkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemg.....

DHRVYTEYCTEIEIGGKSKDKItHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK----------KDKKPVIAHCSAGVGRTGTLAL
. . .     ..    .  | . ||||.|     |.   .. .|. ||.| | .    | . .|  ||          |   |.. ||||||||||... 
ksktfGglevklrtieeisdyv.hrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

IESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYS
. |..| . .  . .. ..   |||||   |.|  ||.    .. |.. |
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
PTPc_DSPc_SM00012 332-428 4.8e-27 89.6 In-house 2-105 (105) alignment 
Range on Protein: 332-428
Range on HMM: 2-105/105.0
LNHYQWASWPDHGMPDSCDTALRLLSAVKKDKK------PVIAHCSAGVGRTGTLALIESMIAALRHP-RKQNVKDSFVLLRKDRARSVQTFPQYVYALR
..||.. .|||||.|...|  |.|| |||| |.      ||. |||||||||||..... ..  |..  .. .... .  ||| |...|||. ||.. .|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CVLE
..||
alle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 198-427 5.2e-27 89.4 In-house 39-274 (287) alignment 
Range on Protein: 198-427
Range on HMM: 39-274/287.0
KDLNRYPNIQCWDRGRFTLAGDENF---YIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVNLEdh
   ||| ..  .|  |  |. . ..   || ||.|   |. |.|...|||.  |   ||.. |   |.|.|..   ||..  || ||  .    . .   
vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG..

rVYTeyCTEIEIGGKSKDkITHRVLKVVvKATGQE-SKLNHYQWASWPDHGMPDSCDTALRLLSAV---------KKDKKPVIAHCSAGVGRTGTLALIE
  |.   . ..   |. .  . | |... .. ..|   .. ... ||||.... ..   .|.   |          ..  |.. |...|.||.|.|  . 
.Gys..vvlldydikePe.ygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

SMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVL
 ..  |    . .|    . ||. ||  ||.  |. .    . 
vlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 243-433 7.1e-27 88.6 In-house 98-291 (302) alignment 
Range on Protein: 243-433
Range on HMM: 98-291/302.0
GPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFVnLeDHRVYTEYCTEIEIGG-KSKDKITHRVLKVVVKATGQESK----LNHYQW
 |  .|.  .| .      . .. ||.||||. .|||.| || || . |   . ||    ...    .  || . .. .| .| . ...|    ..  ..
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvgge.l.kfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

ASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
..||||| |.  .||| .|   .  || |. ||||||||||||  |   |    . .  .. .  . .|. |  .||.  | .| | ||   |  |
sawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmek
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 223-453 1.4e-26 88.3 In-house 48-286 (290) alignment 
Range on Protein: 223-453
Range on HMM: 48-286/290.0
YIHANFVKiCTKPERFVCTQGPMENT-------CTHFWQMALSLGSTSIIMLCGFVEDGSE----KCAKYISDIVG-FVNLEDHRVYteyCTEIEiggkS
|||||.|. | .  |.. || | |..         .|| ||    .....||| | |  ..     ||||. . ||  .....  |    |.. |     
yiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvk...Ckske....k

KDKITHRVLKVVVKaTGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALR-HPRKQNVKDSFVLLRKDR
.| . .| | |     ..| ...|..  .| .  ....  |.| |.. ||. | ||| ||  |. |  .|| |.     .     .....|    ||| |
eddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

ARSVQTFPQYVYALRCVLefLYSKGLYKRNEQEWTK------FKETYAKI
|  ...  .. ...  ..  |. .  ... ..| |.       |||| ||
alaitsalelafvdagiv..llaievldqfaeeetekkakaeeketykki
0051082 (Phosphotyrosine protein) phosphatases II 223-427 2.9e-26 87.3 In-house 5-150 (151) alignment 
Range on Protein: 223-427
Range on HMM: 5-150/151.0
YIHANFVKictkpERFVCTQGPMEntctHFWQMALSLGSTSIIMLCGFVEDGseKCAKYISDIVgfvnledhrvyteycteieiggkskdkithrvlkvv
||....|      ... ...||..    .|...  .|| ..|..|.. .| |  .|..|  .                                      
yinfsyvt.....gglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................................

vkatgqeSKLNHYQWASWPDHGMPDSCDTALRLLSAVKKD-KKPVIAHCSAGVGRTGTLALIESMIaaLRhprkQNVKDSFVLLRKDRARSVQTFPQYVY
        .. |... .|||.|.|.| |..|..|... .. ..||. |||||.||||||...  |.  |.     .. . .  .|. |  .||.. |...
.......ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvqpnqqflf

ALRCVL
 |...|
qlfall
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 176-428 4.8e-26 86.3 In-house 12-264 (283) alignment 
Range on Protein: 176-428
Range on HMM: 12-264/283.0
TKEYKAVGNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKIC---TKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVE
 . .| ..    |.....  . |  ||. .|   |. |  |  . . || | |. .     . .... .|.|...|   ||.|      |.|.||  . |
revlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

DGSEKCAKYISDiVGFvnlEDhrvYTEYCTEIEIGgKSKDKITHRVLKVVVKATGQES-KLNHYQWASWPDHGMPDSCDTA---LRLLSAV-KKDKKPVI
|  .||..|     |    ||   | |.   ..    ...  . . | . |... ...  | |||   | . |     ..     .. |   .. | |..
dlrikCsqyWPk.rGs...ed...yGeftvtlrke.ttsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPiv

AHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
 |||.|.|||...  . . .  ..     .|      .|..|   |||  ||      |||
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
0044763 (Phosphotyrosine protein) phosphatases II 222-425 2.1e-25 84.8 In-house 19-166 (178) alignment 
Range on Protein: 222-425
Range on HMM: 19-166/178.0
FYIHANFVKictkPERFVCTQGPmentcTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGfvnledhrvyteycteieiggkskdkithrvlkv
.||.|...     |  ......|      .....   || |.|..|.. .| | .|| .|  .  |                                  
dyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..................................

vvkatgqesklNHYQWASWPDHGMPD---SCDTALRLLSAVK-KDKKPVIAHCSAGVGRTGTLALIESMIAAlrhprKQNVKDSFVLLRKDRArSVQTFP
            .|..  .|||| ||    .. ..... ..  ....||. ||||||||.|||...  |.       . .. . . |.|. |   |... 
...........iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg

QYVYALRC
|. . ...
qlrqLyef
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 199-431 3.3e-25 83.3 In-house 47-237 (392) alignment 
Range on Protein: 199-431
Range on HMM: 47-237/392.0
DLNRYPNIQCWDRGRFTL----AGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGsekcakyisdivgfvnledh
  ||| ||  .|. |  |       .. |. | ...     . ....|||   .   ||.| .    |.|.|.  . |                      
kknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd....................

rvyteycteieiggkskdkithrvlkvvvkaTGQESK-LNHYQWASWPDHGMPDSCDTALRLLSAVKKDK----KPVIAHCSAGVGRTGTLALIESMIAA
                                |.. .    .... |||...|    . |...  || |     .|.| |||||||||| .  |.|..| 
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvah

LRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
 .. |  .| .  . .|. |   |||  || .   .||| | 
akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_PTPRN_pd Subfamily PTPRN 169-428 8e-25 82.1 In-house 25-290 (297) alignment 
Range on Protein: 169-428
Range on HMM: 25-290/297.0
MSTPQQLTKEYKAVGNIVSDSECT---AFLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVK-ICTKPERFVCTQGPMENTCTHFWQMALSLG
.. ...| ||..|. .  .. ...      |. . ||. ..  .|  | .|      ....|| | ..     .   .. ||||. .| ..||||    |
lknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

STSIIMLCGFVEDGSEKCAKYISDivgfvnlEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVK
.. |..|.   |.| ..|..|  |       | . ||  |  ..       |    | . .    | .   .  . . |||..|.| |  . | .   | 
vvvivnltrleeegvkqckrywpd.......eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvn

KD----KKPVIAHCSAGVGRTGTLALIESMIAALRHP-RKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
|       |.. |||.|.||||.  ||. ... | .  .. ..  .   || .|.  |.|  |. .|| .| |
ksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_egg_pd Subfamily egg 201-431 1.1e-24 81.7 In-house 44-271 (307) alignment 
Range on Protein: 201-431
Range on HMM: 44-271/307.0
NRYPNIQCWDRGRFTLAGDEN----FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDgsEKCAKYISDIVgfvnLEDHRV
 | . ..| |  | .|   .      .|||| ||     . |...| |. ||   ||.|        |.||   .|   |.|  |          .  ..
arskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae....sdslvt

--YTEYCTEIEIGGKSKDKITHRVLKVvVKATGQESKLNHYQWaswpDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMIA-ALRHP
   .   . ...  |.    .   ||. | .  .|  |.|.|.    |        . ||.|  ...  |||. ..  || ...||  ||  .   || |
vpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg....dvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGp

-RKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLY
  |. |. . |.||. |  ||..  .|..  | || |. 
itkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_ptpA1_pd Subfamily ptpA1 178-396 1.7e-24 81.3 In-house 26-262 (418) alignment 
Range on Protein: 178-396
Range on HMM: 26-262/418.0
EYKAVGNIVSDSECTAFLKFK--DLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKiCTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFV
|.. . . |  || .   | .    ||| ||   .. |  |      . . || ||..   . |..|.|||||. || . ||.|        |.||    
efrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid.gaypkqfictqgplpntiadfwrmvwenrcriivmlsres

EDGSEKCAKYISDIVGFVN----LEDHRVYTEYCTE-IEIGGKSKDKITHRVLKVVVKatGQESKLNHYQWASWPDHGMPDSCDTALRLLSAVKKD----
|.   || .|  . .|  .     .   |.  |  | .|.    . .|  | ... ..  |.   . .||.  |||| .||  .   .|| .. .     
encrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe..getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqi

------KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQ
      . |.| |||||||||||..    |.  | |  ||
ipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 235-453 3e-24 80.5 In-house 27-241 (255) alignment 
Range on Protein: 235-453
Range on HMM: 27-241/255.0
PERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYIS-DIVGFVNLEDHRVYteyCTEieiggkSKDKITHRVLKVVVKAT--GQESK
||. .  .     |  .|.|.    ... ..||| | |.| ||| .|.  .  .   |.|  |    .|.      |  ..  | |... . .   .  .
Pekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvt...ttk......ssadvvlrtleitstlgekkktht

LNHYQWASWPDHGMPDSCDTALRLLSAVKKDkKPVIAHCSAGVGRTGTLALIES----MIAALRHPRKQNVKDSF--VLLRKDRARSVQTFPQYVYALRC
..||..  |...  |.     | .| .|..  |.|. |||.|.||. ...|.|.    || .|.     ..        ||. |.|...|  |  ...  
vkhysykGWieknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilm

VLEFLYSKGlykRNEQEWTKFKETYAKI
||.... ||     |..... ...| . 
vldlvfpkg...eleakyqeirksylha
subfamily_CG7180_pd Subfamily CG7180 177-429 1e-21 71.8 In-house 21-289 (296) alignment 
Range on Protein: 177-429
Range on HMM: 21-289/296.0
KEYKAVGNiVSDSECTAFLKFK--DLNRYPNIQCWDRGRFTL---AGDE-NFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGF
.|.| . . ..  .| . |. .  . ||....   |  |  |    |.| . || | .|   .|.. .. |..|...|   ||..    .. ....|.  
lelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtkt

VEDGSeKCAKYISDI--VGFVNLEDHRVYTEYCTEIEIggkSKDKITHRVLKVVVKATGQ---ESKLNHYQWASWPD-HGMPDSCDTALRLLSAVK----
 .    .. .|.       . ... . | ..  ....|    . |.|.... .  . ..    .  . ..|.  |.  . .| |  . . |.  |.    
fdfak.mypsywpnkskeqygeifveiveekqyanlki...rtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwre

K-----DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
|     ...||. ..| |..|.|    |.  .  ...  . .| .    ||..| . |..  .| |    .||.
kvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 176-429 3e-21 70.6 In-house 9-258 (267) alignment 
Range on Protein: 176-429
Range on HMM: 9-258/267.0
TKEYKAVGNIVSDS---ECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVE
 ||.. . .| ..|    .    | .. ||. .   .|  |  |   |. || | .|.   . . |. ||.|..|| |.|...    . . |..|    .
ekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft

DGSEKcakYISDIVGfvnleDHRVYTEYCTEIEIGGKSKD-KITHRVLKVVVKATgQEskLNHYQWASWPDHGMPDSC-DTALRLL--SAVKKDKKPVIA
|   .   .    .|     . . | .   |  .  . .| .|    ||.  ... ..  .  | .  |             . .|    ...  .|.. 
dnirl...fwPPkmg.....qakkyqdltvehslekeendyqiitlelkfknesa.hn..vtlyyykkwnintnnkpylkplfgilaknqlengnrPlvv

HCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
.||.||||.||.  |.|..  ...    .. | .  .|. |   |.|  .|.|  . . |.
acsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 201-353 4.7e-20 66.6 In-house 37-187 (297) alignment 
Range on Protein: 201-353
Range on HMM: 37-187/297.0
NRYPNIQCWDRGRFTLAG--DENFYIHANFVKICTKPE--RFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGFvNLEDHRV
||| .|   |  |  | .   |. || |..|    ...  .....|||...|   ||..    .   |.|.. . ||| .||| |  ..|.  .|.   |
nryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe.rlkagdv

YTEYCTEIEIGgksKDKITHRVLKVVVKatGQESKLNHYQWASWPDHGMPDSCDTAL
  |. ..        |..    |... .   .. ...| |. ||||||.|   .   
vveflsstsde...fdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlv
subfamily_hpo-7_pd Subfamily hpo-7 247-451 6.9e-20 66.0 In-house 45-248 (263) alignment 
Range on Protein: 247-451
Range on HMM: 45-248/263.0
NTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYIS-DIVGFVNLEDHRVYTEYCTEieiggkskD--KITHRVLKVVVKaTGQESKLNHYQWASWPDH
.|   |.|.    ... ..||| | |.| ||| .|   .  .   |..  | |    .        |  . |. .|... .   .  ...||..  |...
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs........dvllktlellstlge.KkkthtvkhysykgWiek

GMPDSCDTALRLLSAVKKDkKPVIAHCSAGVGRTGTLALIES----MIAALRHPRKQNVKDSFV--LLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYK
  |      |..| ....  |....|||.|.||.   ...|.    || .|.     ..    .   ||. |.|...|  |  ...  ||.|..      
ndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakg

RNEQEWTKFKETYA
  | .. . ...| 
eleakyqeirksyl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 164-433 1.9e-19 64.2 In-house 16-288 (302) alignment 
Range on Protein: 164-433
Range on HMM: 16-288/302.0
ASAVMMS-TPQQLTKEYKAVGNI-VSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPERFVCTQGPMENTC---THFWQMALS
| ... | . ....||.|.. .. |.  .|.|| |  . |. ..... |  .  |.. ...|..|  |..    .  . .| |  ..     .||.|. .
akklvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfq

LGSTSIIMLCgfvedGSEKCAKYISDIVGfVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSA
   .|. .|      |.|.. | .|..    . .|.  | .    .    |.... |. |. |. .   .    | |    |... .|..  .. .    
ekivsvvilv.....geeelkktlselfp.kksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaak

V----KKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSK
|     | .....     |.|| |..      .  | .  . |.|.    .|..|.|.|... |||   ...| ..  |
vfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
0048076 (Phosphotyrosine protein) phosphatases II 314-428 2.2e-19 65.0 In-house 30-141 (145) alignment 
Range on Protein: 314-428
Range on HMM: 30-141/145.0
ITHrVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTALRLLSAV---KKDKKPVIAHCSAGVGRTGTLALIESMIAalrhpRKQNVKDSFVLLRKDRA
||. || .    .. | .  .|.. .||||| ||. .. |..| ..    |...||. ||||||||||||...  |.      .. .. . . |.|. | 
itt.vlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrp

RSVQTFPQYVYALRCVLE
 .|... |. . ....||
gavpnpgqlrflyefele
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 183-438 4.1e-18 60.0 In-house 33-287 (303) alignment 
Range on Protein: 183-438
Range on HMM: 33-287/303.0
GNIVSDSECTAFLKFKDLNRYPNIQCWDRGRFTLAgdENFYIHANFVKICTKpERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYI
. .  .     |.|  | ||. .. | |  .  |.  .  ||||..... ..  . . || |.  |.. |||| .      ...|    |  .      .
sylppsvsknqfvknmdknrfvdvicldhskvkls..dssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvf

SDIVGFVNLEDHRVYTEYCTEIEIGgkskdkiTHRVLKVVVKATGQESKL-NHYQWASWPDHGMPDS-----CDTALRLLSAVKK--DKKPVIAHCSAGV
     |...|.  .      ..|.|          ||||.  . |.   .   ... .||   .|            .| | ..|  | .| .    .|.
prnqdflkfeersirvgefkrvelg.......dgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgc

GRTGTLALIESMIAALRHPR-KQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFLYSKGLYKR
||.||.||.|.   .|   .   ..   .  .|. |  .|| . |. .    . | .  .|. | 
gragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickl
0048179 (Phosphotyrosine protein) phosphatases II 318-423 7.4e-18 60.1 In-house 33-138 (144) alignment 
Range on Protein: 318-423
Range on HMM: 33-138/144.0
VLKVVVKATGQESKLN--HYQWASWPDHGMPDSCDTALRLLSAV---KKDKKPVIAHCSAGVGRTGTLALIESMIaalrhPRKQNVKDSFVLLRKDRARS
|. .. .   .. . .  .|.. .||||| ||. .  |..| ..    ....||. ||||||||||||...  |.      .. .... . |.|. |  .
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpga

VQTFPQYVYAL
|... |. . |
vpnpgqlrfLl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 190-428 3.9e-17 57.0 In-house 40-342 (350) alignment 
Range on Protein: 190-428
Range on HMM: 40-342/350.0
ECTAFLKFKDLNRYPNIQCWDRGRFTLA------------GDENFYIHANFVKIC-----TKPE-RFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFV
. .  ..    ||| ||  ... |  |                | || ||..|.       .|. ... ||.|. .|   |... |  . . |..|   |
ilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdv

EDGSEKCAKYISDI------VGFVNLEDHRVYT----EYCTEIEIGGK------SKDKITHRVLKVVVKATGQE-SKLNHYQWASWPDH---GMPDSCDT
| . ||| .|  .       | . .  .  . .     | .....          . .. .    . ....  .   . . |.  |.|      | |  .
elnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilq

ALR--------LLSA---VKKDKKPVIAHCSAGVGRTGTLALIESMIA---ALR----HPRKQ----NVKDS----FVLLRKDRARSVQTFPQYVYALRC
||         | .     ..  .|.. ||||||||||||  ..|..     |.    . ||     ...|        ||| | . ||.  |...   .
alevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYea

VLE
.| 
llf
subfamily_CG42327_pd Subfamily CG42327 218-360 1e-16 55.5 In-house 53-191 (319) alignment 
Range on Protein: 218-360
Range on HMM: 53-191/319.0
GDENFYIHANFVKICT-KPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDIVGfvnLEDHRVYTEYCTEIEiGGKSKDKITH
 |...|..|..|.     |  ....| ..|.. . ||..     |  |. |.   | | ..||.|.    .   |.....| ..   .  |...||.   
ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket...ldntslyGdilvtlk.grevkdryai

RVLkVVVKATGQES-KLNHYQWaSWPDHGMPDSCDTALRLLSAVK
  | .. .  ..|| .| || .  |.. ..| .  . . .|  |.
stl.llkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_PTPN9_pd Subfamily PTPN9 363-433 3.7e-16 54.0 In-house 223-294 (297) alignment 
Range on Protein: 363-433
Range on HMM: 223-294/297.0
KKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEFL-YSK
. |.. |||||.|||||.. ..  .. |..  . .| ..  |||. || |.||  ||..   .|||.  ..|
gPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalelk
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 236-404 3.3e-13 44.3 In-house 5-175 (199) alignment 
Range on Protein: 236-404
Range on HMM: 5-175/199.0
ERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCgfvEDGSEKCAKYISDIVgFVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHY
 |...|| |. .| . ||||    ||  |.|.    .|  .| | |       ..    .  .   |   |  |.   ||  .|   . |     .. ||
rryiatqhplretmadfwqmvwetgsghivmvn...ddqknkeadypfywp.ttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

QWASWPDHGMPDSCD-----TALRLLSAVKKD--KKPVIAHCSAGVGRTGTLALIESMIAALrHPRKQNVKDSFVL
|..|| ..  |. .       | | .|   ..    ||| ||| | | || .  ..  . .     |  | | | .
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsh.eesktsvvdlfev
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 236-404 3.3e-13 44.2 In-house 4-174 (198) alignment 
Range on Protein: 236-404
Range on HMM: 4-174/198.0
ERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCgfvEDGSEKCAKYISDIVgFVNLEDHRVYTEYCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHY
 |...|| |. .| . ||||    ||  |.|.    .|  .| | |       ..    .  .   |   |  |.   ||  .|   . |     .. ||
rryiatqhplretladfwqmvwetgsghivmvn...ddqknkeadypfywp.ttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

QWASWPDHGMPDSCD-----TALRLLSAVKKD--KKPVIAHCSAGVGRTGTLALIESMIAALrHPRKQNVKDSFVL
|..|| ..  |. .       | | .|   ..    ||| ||| | | || .  ..  . .     |  | | | .
qftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsh.eesktsvvdlfev
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 330-432 2.5e-12 40.8 In-house 89-196 (440) alignment 
Range on Protein: 330-432
Range on HMM: 89-196/440.0
SKLNHYQWASWPDHGMPDSCDTALRLLSAVKK-----DKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALR
  |..|.. .|||.|.|  .   |...  |..      . |.. |||||.|||| .  ..|..   ..  . ..      .|..| . |||  ||..   
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhe

CVLEFLYS
.||| | .
avlegllc
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 357-428 5.3e-12 40.2 In-house 222-293 (297) alignment 
Range on Protein: 357-428
Range on HMM: 222-293/297.0
SAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLE
 | .  . ... ||||||||.| . | . ..| ||. |  .|.     ||. ||| |||. |. .    ||.
raemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 357-429 6.1e-11 36.6 In-house 241-314 (319) alignment 
Range on Protein: 357-429
Range on HMM: 241-314/319.0
SAVKKDKKPVIAHCSAGVGRTGTLALIESMIAALRHP-RKQNVKDSFVLLRKDRARSVQTFPQYVYALRCVLEF
|. .... |.. ||| ||||||..   .  |  | .. |  .. .    .|.|||..|.|  || .  . . |.
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_eak_pd Subfamily eak 222-350 2.1e-08 27.9 In-house 79-199 (332) alignment 
Range on Protein: 222-350
Range on HMM: 79-199/332.0
FYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISDivgfvNLEDHRVYTEYCTEIEIGgKSKDKITHRVLKV
 || |  ..     .... |  . |.    |||| |   | .|..|   || . ||  ||  |     .  .   .  .  |       ....  | |..
GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd.....ktreelkfGildverkef.vkrniletrllel

VVkaTGQESKLNHYQWASWPDHGMPDSCD
 .    .  .. ||.   | .  .|   |
sk..GnethrvlhykvfGwtettlpkyed
0038934 (Phosphotyrosine protein) phosphatases II 334-418 2.1e-08 29.5 In-house 81-165 (194) alignment 
Range on Protein: 334-418
Range on HMM: 81-165/194.0
HYQWASWPDHGMPDSCDTALRLLSAV-----KKDKKPVIAHCSAGVGRTGTLAliesmIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQ
.|    .||.| . | .. || |..|     .. .. |  || ||.||||||.     .|.| . .. .....  |.|  |  ....  .
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv.....aaYLiyrlgmsaeeAialfrekRpgaipnqdy
PTPc_motif_SM00404 330-423 2.8e-08 28.8 In-house 47-134 (140) alignment 
Range on Protein: 330-423
Range on HMM: 47-134/140.0
SKLNHYQWASWPDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLALIESMiaalrHPRKQNVKDSFVLLRKDRaRSVQTFPQYVYAL
 .. ...        . .  | .|. .....|... |. || ||| |..||.. . |     . |. ...... .....|  ...   ..|. |
fqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlm.....ryrqlslaeayefvkerR.piispnlnfvrqL
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 190-306 6.6e-08 26.4 In-house 27-145 (332) alignment 
Range on Protein: 190-306
Range on HMM: 27-145/332.0
ECTAFLKFKDLNRYPNIQCWDRGRFTLA---GDENFYiHANFVKICTKPERFVCTQGPMEN-TCTHFWQMaLSLGSTSIIMLCGFVEDGSEKCAKY-ISD
    ||.  |.|| | . |.|. |  ||   | ..||  |..|   .|   .. .| |... |   ||.| .|    |.|.. | ...  .. | | |||
tydkflnnmdmnriphlycfdhsrvelapqdgkddfy.naswvdgyskksayifaqapfndhteyvfwrm.vserkpsmilvfgdidekqkrkapydisd

iVGFVNLEDHRVYTEYCTEIEI
  || .   | . ..   | |.
.rgfeksflhefgaksleecel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 361-408 1.6e-07 25.0 In-house 263-310 (349) alignment 
Range on Protein: 361-408
Range on HMM: 263-310/349.0
KDKKPVIAHCSAGVGRTGTLALIESMIAALRHPRKQNVKDSFVLLRKD
..  ... ||||| ||||.|  ...... |  .... .|  .  |.||
dqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkD
PTEN_1 337-419 4.6e-07 24.8 In-house 99-182 (196) alignment 
Range on Protein: 337-419
Range on HMM: 99-182/196.0
WASWPDHG---MPDSCDTALRLLSAVKK--DKKPVIAHCSAGVGRTGTLAliesmIAALRHPRKQNVKDSFVLLRKDR-ARSVQTFPQY
  ...|||   .   .| . .. .....  ... |. || ||.||.||..     .| | . .| .... . |.|. | ....... | 
hfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv.....aayLmykgkltadeAlelvrekRppgapnspsqe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 217-284 1.4e-06 21.9 In-house 86-155 (349) alignment 
Range on Protein: 217-284
Range on HMM: 86-155/349.0
AGDENFYIHANFVKICT--KPERFVCTQGPMENTCTHFWQMALSLGSTSIIMLCGFVEDGSEKCAKYISD
.|  . || ||..|.      .....|| |.  |   |... |  |   .. |    | . ||| .|  .
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 220-276 1.9e-06 22.2 In-house 12-67 (130) alignment 
Range on Protein: 220-276
Range on HMM: 12-67/130.0
ENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLgSTSIIMLCGFVEDGSE
.| ||.|.|| .  .   .. || |. .|...||.| |      .... | ||.  |
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmler.yvnvlvvlgsveeede
DSPc Dual specificity phosphatase, catalytic domain 341-410 3.5e-06 21.9 Pfam-A 51-115 (133) alignment 
Range on Protein: 341-410
Range on HMM: 51-115/133.0
PDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLAliesmIAALRHPRKQNVKDSFVLLRKDRA
 .  . .  . | . ........| |. || ||. |..||.     || |   .. .... . .....| 
tetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.....iaYlmktknlslneAyefvkerrs
DSPc Dual specificity phosphatase, catalytic domain 341-410 3.5e-06 21.9 In-house 51-115 (133) alignment 
Range on Protein: 341-410
Range on HMM: 51-115/133.0
PDHGMPDSCDTALRLLSAVKKDKKPVIAHCSAGVGRTGTLAliesmIAALRHPRKQNVKDSFVLLRKDRA
 .  . .  . | . ........| |. || ||. |..||.     || |   .. .... . .....| 
tetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.....iaYlmktknlslneAyefvkerrs
subfamily_PTPDC1_pd Subfamily PTPDC1 334-418 4.5e-06 21.2 In-house 85-164 (182) alignment 
Range on Protein: 334-418
Range on HMM: 85-164/182.0
HYQWaSWPDHGMPdSCDTALRLLSAVKK--DKKPVIAHCSAGVGRTGTLaliesMIAALRHPRKQNVKDSFVLLRKDRARSVQTFPQ
.|.. .|.|.|.. | ...| .   |.   ... |  || || |||| |     . . | . .. . ...  |.|. |..|.||  |
vynf.gwkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvl.....iacylvyakrltaekaiklvrskrpksiqtreq
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 218-276 4.7e-06 20.4 In-house 119-176 (244) alignment 
Range on Protein: 218-276
Range on HMM: 119-176/244.0
GDENFYIHANFVKICTKPERFVCTQGPMENTCTHFWQMALSLGSTsIIMLCGFVEDGSE
   | || | ||    .   .. || |. .|   ||.| |      .... | ||.  |
smgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvn.vlvvlgsveeede