Gene Y71G12B.31 in Caenorhabditis elegans

Synonym: CELE_Y71G12B.31, Y71G12B.31

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP230_AA protein Get Run
CeleP230_AA_123-417 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 117-420 7.9e-75 247.4 In-house 22-303 (308) alignment 
Range on Protein: 117-420
Range on HMM: 22-303/308.0
METDYSADSFLASMTKesTNRRRLLQDEFLVLSRTEArRLTRSTDRATRHAAANRYSDIVPYDHTLVELD-TGDYINASFVQGE--SDATRWIATQGPId
. ...| ...|  . |   . . ||. ||  | ..    |..|. .  ..   |||.||.||||. | || . ||||||.|.|       ..||||||  
sslklsvldllkllek..aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPl.

sgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMG-KTERYGEVDVKLVCELEEKTWVHREFDVSPTSsyssstkssrksrasrQQS
      ..|| |||||. ...| .|||| . .|. ..|| .|||. .| ....|| . |.|..| .......|.. .....                 . 
......pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg................dge

HMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDII
  .| ...|. |.| |  | .. .|.|| .|| ..  .|||||||||.||||.||. | .....| || .|.|. |.. |.||| || |. ||. .|...
srtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyral

GEYLRNYH
 |||... 
leylklkl
0051299 (Phosphotyrosine protein) phosphatases II 118-417 1.4e-74 246.5 In-house 2-287 (288) alignment 
Range on Protein: 118-417
Range on HMM: 2-287/288.0
ETDYSADSFLASMTKESTNRRRLLQDEFLVLSRTEARrLTRSTDRATRHAAANRYSDIVPYDHTLVELD------TGDYINASFVQGESDATRWIATQGP
.|..|....|  . |   |   .|..||  | .  .  ||.|. .   .   ||||||.||||. | |       ..||||||...|     ..||||||
dteisveellklvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgP

IDsgecigkETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSamGKTERYGEVDVKLVCELEEKTWVHREFDVSPTSSYSsstkssrksrasRQQ
 .       .||.|||||. ...| .|||| . .|. ..||  |||.  |... ||.. |.|. | .......|.. |.... ..             ..
lp.......ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlld............gdg

SHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGR--QYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIY
 . .| ...|. | | |  . .  .|.|| .||    .  .|.|||||||.||||.||. | .....| || .|... |.| |.||| || |. ||. .|
esrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvy

DIIGEYLR
... |||.
ealleylk
subfamily_PTPRD_pd Subfamily PTPRD 126-419 1.5e-72 240.0 In-house 10-284 (564) alignment 
Range on Protein: 126-419
Range on HMM: 10-284/564.0
FLASMTKESTNRRRLLQDEFLVLSRTeaRRLTRSTDRATRHAAANRYSDIVPYDHTLVEL------DTGDYINASFVQGESDATRWIATQGPIdsgecig
. . . |  .|.   .. |.  ...   .. | .. ..    | |||..||.|||. | |      .  |||||||..|      .||||||.       
lkehvaklkansdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl.......

KETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAmGkTERYGEVDVKLVCELEEKTWVHREFDVSPTSsyssstkssrksrasrQQSHMKVSQW
.||..|||||. ......|||| . .|   .|| .|||.  | ||.|||. |.|. | | .. . |.| .. ..                ... ..| |.
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkk................ssesreVrqF

QYKEWKDTGGAPRIANFLEFLLQVRGR--QYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
.. .| |.|     ...|... .||    . . |||||||||.||||.||  | .. | ..|. .||.. |.. |.||. || | .||  |...| |.| 
hFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala

NY
 .
cg
0046845 (Phosphotyrosine protein) phosphatases II 141-420 5.5e-72 237.8 In-house 2-278 (284) alignment 
Range on Protein: 141-420
Range on HMM: 2-278/284.0
LQDEFLVLSRTEARRL-TRSTDRATRHAAANRYSDIVPYDHTLVEL-------DTGDYINASFVQGE-----SDATRWIATQGPIDSgecigkeTVSDFW
|..||  | .    .| ..|. ..  .   |||.||.||||. | |       ...||||||.|.|          ..|||||| ..       || |||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.......tvedFw

RMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAmGKTERYGEVDVKLVCELEEKTWVHREFDVSPTSSyssstkssrksrasrQQSHMKVSQWQYKEWKDT
||. ...| .|||| .  |. ..||  |||.  |.. .||.. |.|. | .......|.. .....                 . ...| ...|..| | 
rmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgy...............tgesrtvthfhytswpdh

GGAPRIANFLEFLLQVRGRQY----TSPIVVHCSAGIGRTGVFICTDNVISRFESEG---IIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRNYH
|  | ....|||| .||  .      .|||||||||.||||.||. | .....| ||    .|... |.| |.||| || |. ||. .|... |||....
gvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0040438 (Phosphotyrosine protein) phosphatases II 138-420 1.8e-70 233.0 In-house 17-280 (317) alignment 
Range on Protein: 138-420
Range on HMM: 17-280/317.0
RRLLQDEFLVLSRTEARrlTRSTDRATRHAAANRYSDIVPYDHTLVELDT------GDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIV
 ..|..||  | .      |.|. .   .   |||.||.||||. | |         ||||||.|.| .  ...||||||        ..|| |||||. 
ftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.......pntvedFwrmvw

QYDVACIVMLGQHQEDFVQKCGEYWPSamGKTERYGEVDVKLVCELEEKTWVHREFDVSPTssYSsstkssrksrasrqQSHMKVSQWQYKEWKDTGGAP
...| .|||| .  |. ..|| .|||.  |.|  ||.. |.|. | |.. ...|.. |...  ..              . . .| ...|. | | |  |
eqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl..gd..............sesrtvthfhytgWpdhgvpp

RIANFLEFLLQVRGR--QYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRNYH
 .  .|.|| .||    .  .|..||||||.||||.||. . .....| || .|... |.. |.||| .|.|  ||. .||.. |||....
spdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkl
DSPc_SM00195 143-416 2.7e-70 232.1 In-house 4-262 (263) alignment 
Range on Protein: 143-416
Range on HMM: 4-262/263.0
DEFLVLSRTEARRlTRSTDRATRHAAANRYSDIVPYDHTLVELDTG------DYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVA
 ||  | . .  . . .. .  .  . |||..|.||||| |.|..       |||||....|..   ..||||||        ..||.|||||... .| 
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.......pstvedFWrmvweekvk

CIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLVCELEEK-TWVHREFDVSPTSSyssstkssrksrasrqQSHMKVSQWQYKEWKDTgGAP-RIA
.|||| . .|.  .|| .|||. .|..|..|.. |||| . ..|  .. |.. .. .                  . . || |.|||.|.|  |.|    
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk................eetrkvtqyqyknWpdh.gvpdstk

NFLEFLLQVRGRQY--TSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYL
..||.| .|. ..   ..|||||||||.||||.|...| ..|..|.|  .|||. |.. |.|||.|| | .||  ||..| ||.
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 143-416 2.7e-70 232.1 In-house 4-262 (263) alignment 
Range on Protein: 143-416
Range on HMM: 4-262/263.0
DEFLVLSRTEARRlTRSTDRATRHAAANRYSDIVPYDHTLVELDTG------DYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVA
 ||  | . .  . . .. .  .  . |||..|.||||| |.|..       |||||....|..   ..||||||        ..||.|||||... .| 
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.......pstvedFWrmvweekvk

CIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLVCELEEK-TWVHREFDVSPTSSyssstkssrksrasrqQSHMKVSQWQYKEWKDTgGAP-RIA
.|||| . .|.  .|| .|||. .|..|..|.. |||| . ..|  .. |.. .. .                  . . || |.|||.|.|  |.|    
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk................eetrkvtqyqyknWpdh.gvpdstk

NFLEFLLQVRGRQY--TSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYL
..||.| .|. ..   ..|||||||||.||||.|...| ..|..|.|  .|||. |.. |.|||.|| | .||  ||..| ||.
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0047943 (Phosphotyrosine protein) phosphatases II 133-416 5.6e-69 228.0 In-house 6-272 (273) alignment 
Range on Protein: 133-416
Range on HMM: 6-272/273.0
ESTNRRRLLQDEFLVLSRTEArRLTRSTDRATRHAAANRYSDIVPYDHTLVEL--DTGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMI
|. . ..||. ||  | ..    ||.|. .  ..   |||.||.||||. | |  .. ||||||.|.|     ..||||||        ..|| |||||.
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPl.......pntvedfwrmv

VQYDVACIVMLGQHQEDFVQKCGEYWPSAMGK-TERYGEVDVKLVCELEEKTWVHREFDVSPTSsyssstkssrksrasrQQSHMKVSQWQYKEWKDTGG
 ...| .|||| . .|.  .||  |||. .|. ...||.. |.|. | .......|.. .....                 .   .| ...|..| | | 
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg................tgesrtvthfhytgwpdhgv

APRIANFLEFLLQVRGRQY----TSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYL
 | .. .|||. .||  .      .|.|||||||.||||.||. | .....| || .|... |.. |.||| ||.|. ||. .|... |||
ppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 155-421 6.4e-69 227.8 In-house 28-282 (297) alignment 
Range on Protein: 155-421
Range on HMM: 28-282/297.0
RLTRSTDRATRHAAANRYSDIVPYDHTLVELDTGD--YINASFVQGESDATRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGQHQEDFVQKC
  ..|. .  ..   |||.||.||||| | || ..  |||||.|.| .   ..|||||| .       .|| |||||. ...| .|||| .  |.  .||
lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlp.......ntvedFWrmvweqnvtvIvmltelvelgrekc

GEYWPSAMGKTERYGEVDVKLVCELE--EKTWVHREFDVSPTSSyssstkssrksrasrqQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQ---
 .|||. .|..  ||.. |.|. . .  ..... |.. |..| .                . . .| ...|. | | |  . .| .|.|. .|| ..   
aqywpleegesltygdftvtllsvevvllddytlrtlevtdtgn................gesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

-YTSPIVVHCSAGIGRTGVFICTDNVISRFE---SEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRNYHQ
   .|..||||||.||.|.||. | .....|    || .||.. |.  |.||| .| |. ||. .|... |.|... .
psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0045450 (Phosphotyrosine protein) phosphatases II 124-417 3.6e-67 222.6 In-house 12-305 (307) alignment 
Range on Protein: 124-417
Range on HMM: 12-305/307.0
DSFLASMTKESTNRRRLLQDEFLVLSRTEAR-RLTRSTDRATRHAAANRYSDIVPYDHTLVEL-------DTGDYINASFV--------QGESDATRWIA
  .|  . ..  . . .|. ||  | . . .   ..|. .   .   |||.||.||||| | |       ...||||||.|        .|    ...||
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIa

TQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAmGKTERYGEVDVKLVCELEEKTWVHREFDVSPTssyssstkssrksra
|||| ..       || |||||. ...| .|||| .  |.  .|| .|||.  | .  ||.. |.|. | ... ...| . |...               
tqgPlpe.......tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl...............

SRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQ----YTSPIVVHCSAGIGRTGVFICTDNVISRFESEGI---IDIFSEVNRSRQQRPSMVY
.  . . .| ...|..| |.|  | .. .|.|. .||  .      .|..||||||.||||.||. . .....|.||.   .|... |.. |.||| .| 
dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavq

TVKQYECIYDIIGEYLR
.  ||. .|... |.|.
npeqyrflyeallelll
0043336 (Phosphotyrosine protein) phosphatases II 121-416 4.9e-67 221.6 In-house 2-277 (278) alignment 
Range on Protein: 121-416
Range on HMM: 2-277/278.0
YSADSFLASMTKESTNRRRLLQDEFLVLSRTEArrLTRSTDRATRHAAANRYSDIVPYDHTLVELDT------GDYINASFVQGESDATRWIATQGPIDS
.|  ..|  . .   | ..||. ||  | .      |.|. .   .   |||.||.||||..| |.        ||||||.| | .  ...|||||| ..
isvkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe

gecigkeTVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPsamGKTERYGEVDVKLVCELEEKTWVHREFDVSPtsS--YssstkssrksrasrqqS
       || |||||. ...| .|||| .  |. ..|| .|||   |....||.. |.|. | .......| . |..                       
.......tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtn..lgdg................e

HMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGR--QYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYD
  .| ...|. | | |  . .. .|.|| .|| .     .|..||||||.||||.||. . .....|.|| .|... |.. |.|||..| |  ||. .|.
srtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye

IIGEYL
.. |||
alleyl
Y_phosphatase Protein-tyrosine phosphatase 168-412 6.3e-67 220.8 Pfam-A 3-233 (235) alignment 
Range on Protein: 168-412
Range on HMM: 3-233/235.0
AANRYSDIVPYDHTLVEL----DTGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKT
  |||.||.|||.| |.|    .. |||||..|.| ..  ..||||||.       |.|..|||||..|..| .|||| . .|   .|| .|||......
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPl.......kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

ERYGEVDVKLV--CELEEKTWVHREFDVSPTSSYSsstkssrksrasrqqSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQ--YTSPIVVHCSAG
..||.. |.|.   . .|| .. |..... . . |                . .|.|..|..|.| |      ..|... .|. ..   ..|.|||||||
ltygdikvelkekekedekeytlrklelkkkkees...............ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaG

IGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDII
.||||.|.. | .....|.|. .|... |.. |.|||.|| ...||. .|..|
vgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 168-412 6.3e-67 220.8 In-house 3-233 (235) alignment 
Range on Protein: 168-412
Range on HMM: 3-233/235.0
AANRYSDIVPYDHTLVEL----DTGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKT
  |||.||.|||.| |.|    .. |||||..|.| ..  ..||||||.       |.|..|||||..|..| .|||| . .|   .|| .|||......
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPl.......kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeees

ERYGEVDVKLV--CELEEKTWVHREFDVSPTSSYSsstkssrksrasrqqSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQ--YTSPIVVHCSAG
..||.. |.|.   . .|| .. |..... . . |                . .|.|..|..|.| |      ..|... .|. ..   ..|.|||||||
ltygdikvelkekekedekeytlrklelkkkkees...............ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaG

IGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDII
.||||.|.. | .....|.|. .|... |.. |.|||.|| ...||. .|..|
vgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0039614 (Phosphotyrosine protein) phosphatases II 130-420 4.5e-66 218.7 In-house 23-293 (297) alignment 
Range on Protein: 130-420
Range on HMM: 23-293/297.0
MTKESTNRRRLLQDEFLVLSRTEARrltRSTDRATRHAAANRYSDIVPYDHTLVEL-------DTGDYINASFVQGESD-ATRWIATQGPIDSgecigke
  .|  | . ||. ||  | .       .|. .   .   |||.||.||||. | |          ||||||.|.| .    ..|||||| ..       
lllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe.......

TVSDFWRMIVQYDVACIVMLGQHQEDFVqKCGEYWPSAMGkteRYGEVDVKLVCELEEKTWVHREFDVSPtssYSsstkssrksrasrqqSHMKVSQWQY
|| |||||. ...| .|||| .  |. . || .|||. .|   .||.. |.|. . ... ...|.. |..   ..                  .| ..||
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn...ng...............esrtvthfqy

KEWKDTGGAPRIANFLEFLLQVRGRQ----YTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
  | | |  | .. .|||| .|| ..       |..||||||.||||.||. . .....|.|| .|... |.. |.||| .| |  ||. .||.. |.|.
tgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

NYH
...
rkl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 128-412 2.4e-64 212.2 In-house 10-275 (288) alignment 
Range on Protein: 128-412
Range on HMM: 10-275/288.0
ASMTKESTNRRRLLQDEFLVLSRTEARRLTRSTdRATRHAAANRYSDIVPYDHTLVELDT------GDYINASFVQGESDATRWIATQGPIdsgecigKE
|  .| | . |  ...|. .|.  |  . .  . | .. |  ||| .|.|||.. |.|.        ||||||...||    ..||||||.        .
akvakksarnrtgfseeynsLaalektksvtag.rlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPl.......ad

TVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAmGKTERYGEVDVKLVCELEEKTWVHREFDVSptssyssstkssrksrasRQQSHMKVSQWQY
|| |||... ....  |||| .  |.  .||.||||.| .| ..||.|.|.|| . |.. .|.|.. .                   ........ |.||
tvndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..................kkkteleitqyqy

KEWKDTGGAPRIANFLEFLLQVRGRQYT--SPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDII
. | |.|     |..||.| ||   .     ||.||||||.||||.||  |..| . |.|  ||... |.. |.||...| |.|||| ||...
laWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 137-419 8.2e-63 207.4 In-house 18-283 (318) alignment 
Range on Protein: 137-419
Range on HMM: 18-283/318.0
RRRLLQDEFLVLSRTEARRLTRSTdRATRHAAANRYSDIVPYDHTLVELD------TGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMI
 . ||. |.  |||.|.   .  .      .| ||| .|..|||| |.|.      . |||||....|      .||.|.|.        ||..|||||.
Gelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPl.......petieDfWrmv

VQYDVACIVMLGQHQEDFVQKCGEYWPSAmgKTERYGEVDVKLVCELEEKTWVHREFDVSPTssyssstkssrKSRASRQqshmkVSQWQYKEWKDTGGA
 . . | |||| | .|   .|.  ||||   ... ||.. |.|  |.| ...| ||| |. |           .. .|||     | |..| .| |.|  
WeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrt...........eeeesrq.....vrqyhytsWpdegvp

PRIANFLEFLLQVRGRQ---YTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRNY
   |..|... ||.  |    ..|||||||||.|||||||  | .. | . |...|.|  |.. |.||. || | .||| |||.. |.|  .
esgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
0045098 (Phosphotyrosine protein) phosphatases II 166-419 2e-62 206.4 In-house 33-275 (278) alignment 
Range on Protein: 166-419
Range on HMM: 33-275/278.0
HAAANRYSDIVPYDHTLVEldtgDYINASFVQGEsDaTRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSamGKTER
... |||.||.||||. |     ||||||...|  . ...|||||| .       .||.|||||. .... .|||| . .|. ..|| .|||.  |....
nldknRykdilpydhsrVk....dYINAsyidgy.p.kkfIatqgPlp.......stvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggslt

YGEVDVKLVCELEEKTWVHREFDVSPTSSYSSStkssrksrasrqQSHMKVSQWQYKEWKDTGGAPRI--ANFLEFLLQVRGRQ---------------Y
||.. |.|. | . .....| . |  .... ..               ..| ...|. | | |  .    . |||.| ..| ..                
ygdftvtllseevlddytlrtllvtnltvered............lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

TSPIVVHCSAGIGRTGVFICTDNVISRFesEGIIDIFSEVNRSRQQRPS-MVYTVKQYECIYDIIGEYLRNY
  |..||||||.||||.... . .....  || .|... |.  |.|||  .| .  ||. .|. . |.|...
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPRB_pd Subfamily PTPRB 123-421 2.7e-62 205.4 In-house 9-290 (293) alignment 
Range on Protein: 123-421
Range on HMM: 9-290/293.0
ADSFLASMTKESTNRRRLLQDEFLVLSRTEARRLTRSTDrATRHAAANRYSDIVPYDHTLVEL------DTGDYINASFVQGESDATRWIATQGPIdsge
...| . ..| ...    ...|.  |.  .  . . ... ... .| |||..|.||||. |.|      .. |||||....| .    .||||||.    
lekfeehvkkmkadsdlrfseeyeelkavgkdqavkaae.lavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl....

cigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMgKTERYGEVDVKLVCELEEKTWVHREFDVSPtssyssstkssrksrasrQQSHMKV
    ||| |||||. .  .  |||| |  |   .|| ||||.   ..  ||.. |.|| | | . || ||. ..                   .....||
...petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek..................ekeerkv

SQWQYKEWKDTGGAPRIANFLEFLLQVRGRQ----YTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDII
 |.... | | |   . ...|.|. .|| ..     ..|||||||||.||||.||. |..... |.| ..|||. | . |..| ..| |.||| .|.. .
rqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcv

GEYLRNYHQ
 ..||. ..
ldllrkkee
0040439 (Phosphotyrosine protein) phosphatases II 159-417 2e-61 203.1 In-house 4-247 (249) alignment 
Range on Protein: 159-417
Range on HMM: 4-247/249.0
STDRATRHAAANRYSDIVPYDHTLVELDT------GDYINASFVQGESDATRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQEDFVQKC
|. .   .   |||.||.||||. | |        .||||||.. |    .|.|||||| ..       ||.|||||. .... .|||| . .|   .||
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe.......tvedfwrmlwelgitvivmLtslvelgrekc

GEYWPSamGKTERYGEVDVKLVCELEEKTWVHREFDVSPTSsyssstkssrksrasrQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQ----Y
 .|||.  |..  ||.. |.|. . ... ...|.. ....                  ... .| ..||  | |.|  | .. .|.|. .||  .     
aqywpl..ggsleygdftvtllsvevkddytvrtleltnly................dgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpk

TSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
 .|..||||||.||||.||. . .....| |. .|... |.  |.||| .|..  ||. .|... |.|.
ggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_PTPN6_pd Subfamily PTPN6 135-421 7.3e-61 200.8 In-house 22-302 (306) alignment 
Range on Protein: 135-421
Range on HMM: 22-302/306.0
TNRRRLLQDEFLVLSRTEARR-LTRSTDRATRHAAANRYSDIVPYDHTLVEL-----DTGDYINASFVQGESD--ATRWIATQGPIdsgecigKETVSDF
.  .  ...||  |...||.. |.|.  . .. .  |||  |.|.||| | |        |||||.....|.    ...||||| .       ..|||||
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcl.......ettvsdF

WRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTErYGEVDVKLVCELEEKTWVHREFDVSPTssyssstkssrksraSRQQSHMKVSQWQYKEWKD
|||..| .   |||. .. |   .||  |||..  |.| ||.. |. | | . .... ||. || .               ...... .| |...|.| |
WrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk...............kkkkeerevfqyhfksWPd

TGGAPRIANFLEFLLQVRGRQYT------SPIVVHCSAGIGRTGVFICTDNVISRFESEGI---IDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
 |       .|.|| .|. .| .       |||||||||||||| || .| ...  |..|.   ||| . |.  |.||  .| | .||  .| .| .|..
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

NYHQ
. ..
tkkk
subfamily_Ptp69D_pd Subfamily Ptp69D 127-416 1.5e-60 199.9 In-house 10-286 (307) alignment 
Range on Protein: 127-416
Range on HMM: 10-286/307.0
LASMTKESTNRRRLLQDEFLVLSRTEARRLTRSTDRAtRHAAANRYSDIVPYDHTLVEL------DTGDYINASFVQGESDATRWIATQGPIDSgecigk
  ....   .   .|. |.  | ..|  . |. ...    |  ||| ||...|.| | |      .. |||||||..|  .  ..|| |.|...      
eealksrkrdtdfglakeyekLeareidkstkvsekk.enalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea......

eTVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAmgKTERYGEVDVKLVCELEEKTWVHREFDVSPTSSYSSSTkssrksrasrqQSHMKVSQWQ
 |. |||||| . .|  |||| . .|   .||  |||    .. .||.. |||| | . . ...||.||| .   |.             . . || |..
.tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgev...........edsrkvvqyh

YKEWKDTgGAPRIA-NFLEFLLQV--RGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYL
|..|||.  .|. |   |... ||    ..  |||||||||| ||.|.|.. | .. . . |  .|||  |   |.||. .|   .||. .|  . .| 
ytgWkDs.kvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 133-419 1.2e-59 197.0 In-house 21-293 (298) alignment 
Range on Protein: 133-419
Range on HMM: 21-293/298.0
ESTNRRRLLQDEFLVLSRTEA--RRLTRSTDRATRHAAANRYSDIVPYDHTLVELDT------GDYINASFVQGESDATRWIATQGPIdsgecigKETVS
. ...   ...||  |....   .. . .  |...    |||.||...|.. | | .      .|||||||... .. . .||||.|.       .|||.
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPl.......tetve

DFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAmgKTERYGEVDVklvceleektwvhrefdvSPTSSYSSSTKSSRKSRA--SRQQSHMKVSQWQYK
|||||....|...|||| . .|    |. .|||.   ..|.|||..|                  |  |... .   .||     ...... .| | .. 
dFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitv..................sllskeefadlivrklkvskkkeekerevrqlhft

EWKDTGGAPRIANFLEFLLQVRGRQYTS---PIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRNY
.| | | .      |..| .||  |. .   |..|.||||.||.| ||  | |. | . |  .|.|  |.. |..|| .| | .||  ||... |.|  .
sWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
0042113 (Phosphotyrosine protein) phosphatases II 163-417 1.3e-58 193.6 In-house 6-244 (245) alignment 
Range on Protein: 163-417
Range on HMM: 6-244/245.0
ATRHAAANRYSDIVPYDHTLVELDT------GDYINASFVQGESDATRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYW
   .   ||||||.|||||.| |         ||||||.| |     ..|||||| ..       || |||||. .... .|||| .  |.  .|| .||
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe.......tvedfwrmlwelgittivmLteeeelgrvkcaqyw

PSamGKTERYGEVDVKLVCELEEKTWVHREFDVSPTssyssstkssrksrasRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRG---RQYTSPIV
|.  | . .||.. |.|. |  ......|.. |...                .   . .| ...|  | | | .. .. .|.||  ||    .    |..
pl..gesltygdftvtllseehlddytvrtlevtnl................gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvl

VHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
||||||.||||.||. . .....|.|. ..... | . |.||| .| |  ||. .|... |.|.
VHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 158-417 1.2e-57 190.4 In-house 38-284 (305) alignment 
Range on Protein: 158-417
Range on HMM: 38-284/305.0
RSTDRATRHAAANRYSDIVPYDHTLVEL---D---TGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQK
   .. . ..|.||...|...|.  . |   .     ||||||.|.| .   ..|..|||.       |.||.||||.||.. |  |||| . .|.  .|
idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPl.......kntvadfWrliveekvstivmltklveggkdk

CGEYWPSAMGKTERYGEVDVKLVCELEEKTWVHREFDVSPTSSyssstkssrksrasrQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQYTS-
|  ||| ........||. |.|  | . . .. |.. .|  ..               ..    |.|.|  .| | |     . .|... .|. .|  . 
CrqYWpesktekkefgefsvelksektasdyieRklkisiede...............dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

--PIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
  |..||||||.|||||||. |  . | . |...|.|  ... |..|. || | .||  ..|.. |.. 
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 133-418 3.2e-57 189.0 In-house 17-285 (319) alignment 
Range on Protein: 133-418
Range on HMM: 17-285/319.0
ESTNRRRLLQDEFLVLSRTEARrlTRSTDRATRHAAANRYSDIVPYDHTLVELD------TGDYINASFVQGESDATRWIATQGPIDsgecigkETVSDF
  ..  .||. ||  |. ...   | ..    .    |||..|..||.| | |         |||||||..|  . ...||||.|..       .|..||
lastgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle.......ntiedf

WRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAmgKTERYGEVDVKLVCELEEKTWVHREFDVSPTSSYSSStkssrksrasRqqshmKVSQWQYKEWKD
|||. .... ..||| . .|    |. .|||..  . |.||.. |.|  | | . .. |.. . . ||   .          |     .|...||.|| |
WrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevet..........R.....evkhfqyteWpd

TGGAPRIANFLEFLLQVRGRQ---YTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRN
 .   .    |..| ..|  .      |||||||||.|||| ||  | .. | . ||..|.|| |.| | ||. || . .||. ||... |..  
hdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_PTPRA_pd Subfamily PTPRA 132-415 5.3e-56 184.9 In-house 25-294 (330) alignment 
Range on Protein: 132-415
Range on HMM: 25-294/330.0
KESTNRRRLLQDEFLVLSRTEARRLTRSTDRaTRHAAANRYSDIVPYDHTLVEL------DTGDYINASFVQGESDATRWIATQGPIdsgecigKETVSD
. |..  .|...||  |  .. .     ...       ||. .|.|||.. | |      .. |||||||..|  .  ..||.|||        .||| |
irsaddnklfreefnalPagpiqatlelask.eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPk.......eetved

FWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTerYGEVDVKLVCELEEKTWVHREFDVSptsSYSsstkssrksRASRQQSHMKVSQWQYKEWK
||||| ... | |||| . .|   .||  |||.    |  ||.. |..  | . . .  |.| |      .          |.|....  |.|. .. | 
fwrmiweqksativmltelkerkeekcaqywPdeGlvt..yGnirvevedetvlvdytvrkflvq...qlp.........datrekksrlvrqfhftswP

DTGGAPRIANFLEFLLQVRG--RQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEY
| |        |..| .|.   .|...|||||||||.|||| ||  |.|. | ..|...|.|  |.| |.||| || | .||| || .. ||
dvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
0037934 (Phosphotyrosine protein) phosphatases II 166-415 1.1e-55 184.2 In-house 10-241 (243) alignment 
Range on Protein: 166-415
Range on HMM: 10-241/243.0
HAAANRYSDIVPYDHTLVELDTGDYINASFVQGESdatRWIATQGPIDSgecigkeTVSD----FWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPsamG
.   ||||||.||||. | |. .|||||.....     |.|||||| ..       || |    ||||. .... .|||| . .|  ..|| .|||   |
nlsknrysdilpydhsrvklegsdyinanliyvtp...rliatqgPlpe.......tveddlasfwrmlwelgitvivmltelvElgrekcaqywp...g

KTeRYGEVDVKLVCELEEKTWVHREFDVSptssyssstkssrksRASRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVR----------GRQYTSP
.. .||.. |.|. | . . ...|.. ..               . . .. .  | ...|  | | |  . ....|.|| .||           .   .|
ev.tygdftvtllseehlddytvrtllle...............nldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggp

IVVHCSAGIGRTGVFICTDNVISRFeseGiIDIFSEVNRSRQQRPS-MVYTVKQYECIYDIIGEY
..||||||.||||..|. . .....   | .|... |.. |.|||  .| |  ||. .|... |.
vlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 128-420 2.3e-55 182.5 In-house 9-287 (290) alignment 
Range on Protein: 128-420
Range on HMM: 9-287/290.0
ASMTKESTNRRRLLQDEFLVLSRTEArRLTRSTDRATRHAAANRYSDIVPYDHTLVELD--------TGDYINASFVQGESDATRWIATQGPIdsgecig
  .... .. ..  ...| .|  .|    |  .. ..     ||...||.||   . |         | .||||....| ... ..||||||.       
efvanghakgnegfrnqfkmldsges.ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpv.......

KETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAmgKTERYGEVDVKLvceleektwvhrefdvspTSSYSS----STKSSRKSRASRqQSHMK
..|. |||..|.| .|..|||| . .|.  .||  |||..  .|..|||. .||                  ..  .      .| . |.. |  ... .
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikl..................lneetlneyierklevknknsa.gakqs

VSQWQYKEWKDTGGAPR---IANFLEFLLQVRGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDII
| |.| . |..||  .    |   .|   . . ..   .||||||...||..||. ... | . ..|| ||.|. ... |.|.| .| ||.||. |..|.
vtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv

GEYLRNYH
 .|| ...
ltyldsfe
subfamily_PTPN23_pd Subfamily PTPN23 133-422 6e-55 181.1 In-house 9-286 (288) alignment 
Range on Protein: 133-422
Range on HMM: 9-286/288.0
ESTNRRRLLQDEFLVLSRTEAR-RLTRSTDRATRHAAANRYSDIVPYDHTLVELD--TGDYINASFVQGES-DATRWIATQGPIDSgecigkeTVSDFWR
.  . .  |. .|  | .....    ||.  | ...  ||. ||.||||. | |.  . ||||||||.. |  .  .||||.|..|       |..|||.
kmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqs.......tlnDFWl

MIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLVCELEEKTWVHREFDVSptssyssstksSRKSRASRQQSHMkvsqwQYKEWKDTG
|...  .  |||| ...| . .|. .|||.. |.|...|...| |  . | .|.|.|.. ..            ....| .. ||.     |...| . |
mvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkle...........tldadavksvshl.....qltsWpelG

gAPR-IANFLEFLLQVRG------RQYTSPIVVHCSAGIGRTGVFICTDNVISRFE-SEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRNYH
 .|    ..|.|| .|.       |.   |.|||||||.|||||| .   ..  .|  .|..||   |.| |.||  || ...|..  |... |. |.. 
.vPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl

QK
.|
dk
subfamily_PTPRK_pd Subfamily PTPRK 165-414 2e-54 179.6 In-house 42-275 (314) alignment 
Range on Protein: 165-414
Range on HMM: 42-275/314.0
RHAAANRYSDIVPYDHTLVELDT------GDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPS
 . . ||. ||..||...| | |       |||||... .   .. .|.||||.       .||| ||||.. ... |.|||| . .| .  || .||| 
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPl.......qetvkdfWrlvydencasivmltelvevgrvkClkyWPe

amgKTERYGEVDVKLVCELEEKTWVHREFDVSPtssyssstkssrksRASRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQY--TSPIVVHC
   .|| ||...|.||    ..  |.| | |.                |  |. . .| |.|.  | | .       .|... .|   |     .|||||
...dtevygdikvelvetellaelvvrifrvek..............largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhC

SAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGE
||| ||||.||  | |.   | ||..|.|  |   |.... || | .||  |||.| |
saGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 136-419 1.2e-53 177.0 In-house 17-281 (287) alignment 
Range on Protein: 136-419
Range on HMM: 17-281/287.0
NRRRLLQDEFLVLSRTEARRLTRSTDRATRHAAANRYSDIVPYDHTLVELD--TGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQY
. .   .. | || . . |.     . |..    ||...|...|   | |     |||||.|..| ... ..|....|.        .|. .||..| . 
kgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPm.......fntarnfWkliddr

DVACIVMLGQHQEDFVQKCGEYWPSAMGktERYGEVDVKLVCELEEKTWVHREFDVsptssyssstKssrksRASRQQSHMKVSQWQYKEWKDTGGAPRI
 |  |||| |..|.  ..| .|||.       .||  ..|. |  .. .. |...|          |     . ...... .| |.|. .|..||  .. 
nvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklev..........k.....nknkagdkqqvkqyqitnWdstgkvtep

ANFLEFL---LQVRGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRNY
.  |  .    . . ..  ..||||||...||...|.  .  | . . ||.||.|. ... |.|.| .| ||.||. |.||. |||  .
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
subfamily_PTPN12_pd Subfamily PTPN12 157-418 3.8e-53 175.3 In-house 31-279 (290) alignment 
Range on Protein: 157-418
Range on HMM: 31-279/290.0
TRSTDRATRHAAANRYSDIVPYDHTLVELD------TGDYINASFVQGESDATRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGQHQEDFVQ
.... ..... . ||| ||.|||.. |||         |||||.|..| .. ...||.|||.        .|..|||||| ...|  .||. .  |   .
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLp.......ktlddfWrmiweknveivvmaCrevelgkk

KCGEYWPSAMGKTERYGEVDVKLvcelEEKTWVHREFDVsptssyssstkssRKSRASRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQY--
||  |||. .... ..||. |.|    ||. .|. .| .             |  .. .|. . || |..|..| | |   .. . ||.. .|| .|   
kCerYWpeegeeelefgefevtl....eeekavdddfli.............rtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqese

TSPIVVHCSAGIGRTGVFICTDNVISRFESEGI---IDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRN
 .|.|||||||.||||. |  | | . ...| |   .|.|. | . |.||...| | .||| .|  . |....
daPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 147-412 3.3e-52 172.1 In-house 14-262 (283) alignment 
Range on Protein: 147-412
Range on HMM: 14-262/283.0
VLSRTEARRLTRSTDRATRHAAANRYSDIVPYDHTLVELDT--GDYINASFVQ---GESDATRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVML
|| |     |    . | ..   ||. .|||.|   |||..   |||||.|.     . .  ..|..|.|.|       .|| |||.|. . ....||||
vlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPld.......rtvvdfWkmvfdekitaivml

GQHQEDFVQKCGEYWPSAmGkTERYGEVDVKLVCELEEKTWVHREFDVSPTssyssstkssrksraSRQQSHMKVSQWQYKEWKDTGGAPRIANFLEF--
 . |||  .||  |||.  | .| |||  | |  |  ..... .|. .                  |  .| . .. .|. .| . |  . |  .. |  
tklqedlrikCsqyWPkr.G.sedyGeftvtlrkettsnsfiikelllrvn...............ssakstlllahyqvidWleygeqaiinslvkfnk

LLQVRGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDII
.   . ..  .|||||||.|||||.|||     .    .| ..|.|. |.  |.||. .| |  ||  .....
vislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_PTPN3_pd Subfamily PTPN3 155-412 4.4e-52 171.7 In-house 30-271 (280) alignment 
Range on Protein: 155-412
Range on HMM: 30-271/280.0
RLTRSTDRATRHAAANRYSDIVPYDHTLVELDTG--DYINASFVQGESDA----TRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDF
 |. |. | .. .. ||| ||.|||.| |.|. .  |||||..|. |...    .|.||||||.       ..|..|||.|. . ..  |||| .  |. 
glaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPl.......aktatdfWqmvweqksslivmlttlverG

VQKCGEYWPSaMGKTERYGEVDVKLVCELEEKTWVHREFDVSPTSsysssTKSSRksrasrqqshmKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQ-
 .|| .|||. .... .||| .||.  | |.|..| ||. .. ..     || .|           |. | || .| | |     |.||||. .||  . 
rvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdke.....tkeer...........kilqlqylaWpdhgvPddsadflefvervrklrs

-YTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDII
  ..|.|||||||||||||.|  .  ..  |..  . .   | . |.|| ..| |..||. . . |
gkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 165-418 5.8e-52 171.4 In-house 8-244 (250) alignment 
Range on Protein: 165-418
Range on HMM: 8-244/250.0
RHAAANRYSDIVPYDHTLVELD------TGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDfVQKCGEYWPS
.    |||.||...|.. | |         |||||||..| ..   .||||||.       ..|. |||||....... |||| . .|   ... .||| 
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPl.......qatiedfWrmvleeksgtivmLtnLkes.ektyhqywPv

amGKTERYGEVDVKLVCELEEKTWVHREFDVSptssyssstkssRKSrasrQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQYT---SPIVVH
   |.|.||.| |.|  . |   ...|.. .|            ...    ....  | | ..  | | |        ||.| .|.  |     .|..|.
..ekaekyGdvtvsllskeefadytkrklkls............kak....kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivq

CSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRN
||||.||.| ||  | |. | . | ..|.|  ... |..|| .| . .||  .| || ..|  
CsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 139-417 8.1e-52 171.0 In-house 19-278 (315) alignment 
Range on Protein: 139-417
Range on HMM: 19-278/315.0
RLLQDEFLVLSRTEARRLTrsTDRATRHAAANRYSDIVPYDHTLVEL------DTGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQ
 |. .||  |   .. | .  . | |     ||| .|.|.|.. | |         ||||||....  |   .||.|||        | .|.|||||..|
alfseefhdlpdPdiyrqr..varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPl.......kasvddfwrmvlq

YDVACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLVCELEEKTWVHREFdVsptssyssstksSRKSRASRqqshmKVSQWQYKEWKDTGGAPR
..|. |||. . ||.   ||  |||   ... ..|.. |.|.        |.|.. |             ||| .||     .|.|.|..|| | |   .
ekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.v............trkseesr.....tvtqfqftewPdkGvdkq

IANFLEFLLQVRG--RQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
 . .|... .|..  .... ...||||||.|||||.|  |.|... . .  .|.|  |.  |..|| .| | ..|  |||.. |.| 
tssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 168-417 8.9e-52 170.8 In-house 45-277 (515) alignment 
Range on Protein: 168-417
Range on HMM: 45-277/515.0
AANRYSDIVPYDHTLVEL------DTGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMG
  ||| .|.||| . | |         ||.|||....      .||.|||        | .|.||||...|..|. |.|. . .|.   |||.|||   |
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPn.......kasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

KTERYGEVDVKLVceleektwvhrefdvsptSSYSSSTKSSRKSRASRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRG--RQYTSPIVVHCSAG
.. ..|.. |.||                  |  . .    || .  ...    | |....|| | |  ..   .| .. .|.    ||| |...|||||
dsvkfGsikvelv..................sleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaG

IGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
.|||||.|  |.|... .   ..|.|  |.  ||.|| .| |  ||  ||... |.| 
vGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 130-419 1.2e-51 170.4 In-house 6-279 (281) alignment 
Range on Protein: 130-419
Range on HMM: 6-279/281.0
MTKESTNRRRLLQDEFLVLSRTEARRLTRSTdRATRHAAANRYSDIVPYDHTLVEL------DTGDYINASFVQGESDATRWIATQGPIDsgecigkETV
. ..|.|  . .. |.  |.  . .  .... .|      ||||.|| ||.| |..       . |||||.||.| .. ...||||||.        ...
lkqlsqndnaGfieeyeklaaigvdntatas.kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvP.......asl

SDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMgKTERYGEVDVKLVCELEEKTWVHREFDVspTssyssstksS-----RksrasrqqshmKVSQ
 .||.|.....|  |||. .  |    ||  |||    .. .||.| || . | |..|...|.| .  .               |           .|.|
vafWqmvweqkvsaivmvtreieagklkChrYWPddn.selkygdvtvkstaeeekatyierkfkl..e.........resgetr...........eveq

WQYKEWKDTGGAPRIANFLEFLLQV---RGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESE-GIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGE
 .|. | |.|     ...|||  .|   . ..   |.|.|||||.||||..|  | .... |.|   .|.   |.  |..|  || || ||| .| .. .
laytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld

YLRNY
.| ..
aldke
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 112-414 3.2e-51 169.5 In-house 8-289 (319) alignment 
Range on Protein: 112-414
Range on HMM: 8-289/319.0
QSAIAMEtDYSADSFLASMTKESTNRRRLLQDEFLVLSRTEARRLTRSTDRATRHAAANRYSDIVPYDHTLVELD------TGDYINASFVQGESDATRW
.| .|.. |. |     |  ..  . .. |. ||  ...  .   ...     .    ||. .|...|.. | |.        ||||||||.|     ..
esdvavp.dfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdky

IATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGqhqedfVQKCGEYWPSAMGKTERYGEVDVKLVCELEEktWVHREFDVSptssyssstkssrks
||.||| |       .|. |||||| .|... ||.|        .|| .|||  . ..|  ..|.|..| | .|  .| |....|               
iaaqGPld.......ntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdiels...............

RASRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVR----GRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYT
. ....   |. |. .. | | |     .... .. .||      .   .||||||||.|||||.|  | ...|.. |  .|..  |.  ||||. .|  
edgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqd

VKQYECIYDIIGE
. ||  ||  . |
lvqykfiysalle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 139-418 5.6e-51 168.2 In-house 5-270 (274) alignment 
Range on Protein: 139-418
Range on HMM: 5-270/274.0
RLLQDEFLVLSRTEarrlTRSTDRATRHAAANRYSDIVPYDHTLVEL-------DTGDYINASFVQGESDA-TRWIATQGPIdsgecigKETVSDFWRMI
. |..||| |        ..   . ....  ||| .|.| ... | |       .  .|||| ...| .   . ..|||||.        .||.||||||
kdlekeflelPlnf....dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPl.......pntvadfWrmi

VQYDVACIVMLGQHQEDFVQKCGEYWPSAMGK--TERYGEVDVKLVCELEEKTWVHREFDVSPTSSYSSstkssrksrasrqqshmkVSQWQYKEWKDTG
 | .|  |||| . .|   ||| .|.| | .   .||||.|..| .  .|.. .  |.. .. ...  |                  |  . | .| |. 
yqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers..................vkhywytdWPdhk

GAPRIANFLEFLLQVRGRQ-----YTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRN
   .. ..|...|.|.  .      ..|.||||||||||||.|| ... . ... |...|... |   |..|  || | .||| |. .. .||..
sPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPRG_pd Subfamily PTPRG 137-417 1.3e-50 167.2 In-house 17-288 (563) alignment 
Range on Protein: 137-417
Range on HMM: 17-288/563.0
RRRLLQDEFL-VLSRTEARRLTRSTDRATRHAAANRYSDIVPYDHTLVELDT-------GDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWR
    .. ||  . |.| .. |. .. ...     |||..||.||.. |.|          |||||....|   .  .||||||.       |.|. ||||
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl.......kdtfddFWr

MIVQYDVACIVMLGQHQEDFVQKCGEYWPSamGKTERYGEVDVKLVCELEEKTWVHRefdvsptssySSSTKSSRKSRASRQQSHMKVSQWQYKEWKDTG
|| .  || |||. . .|.  .||  |||.   ..|.||.. |.|. |    .   |          . . |  .. . ...... .| |..| .| |.|
miWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvr..........tlviknlklkkkkqcdteklvrqyhytkWPdhg

GAPRIANFLEFLLQVRGR--QYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
     .  | |  .      . . |||||||||.||||..|  | .. . ..| ....|  . . | ||. .| |  ||  ..|.. | ..
vPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 139-417 2.1e-49 163.3 In-house 26-285 (297) alignment 
Range on Protein: 139-417
Range on HMM: 26-285/297.0
RLLQDEFLVLSRTEARRLTRSTDRAtrHAAANRYSDIVPYDHTLVELD------TGDYINASFVQGESDatRWIATQGPIdsgecigKETVSDFWRMIVQ
 . ..||| | ... .  | . ..       .||..|.|||   |.|         ||.|||||.|     |.|.|| |        |.|| |||.|...
dvfseeflclpeaniqpqtvaekkv..nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPm.......katvadfWamvld

YDVACIVMLGQHQEDFVqKCGEYWPSAMGKTerYGEVDVKLVCELEEKTWVHREFDVsptssysssTKSSRKSRASRQQSHmkVSQWQYKEWKDTGGAPR
..|. |||| . .|    ||  ||.    .|  .|.| |.| .  | .  ..||..|         ||.. |.|   .| .    .|  |. .    |. 
eqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelev.........tkgkakarrvvkqyq..fveWPdkaverkdsass

IANFLEFLLQVRGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
. .... . .. . .  .|..|||.||.|||||..  |.|... . |  .|||  |.. ||.|| .| | .||. .| .. |.| 
llklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 169-414 3.2e-49 163.0 In-house 28-253 (284) alignment 
Range on Protein: 169-414
Range on HMM: 28-253/284.0
ANRYSDIVPYDHTLVELD------TGDYINASFVQGESDATRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGqhqedfVQKCGEYWPSAMGK
 ||. .|...|.. | |.        |||||||..|     ..|||||| |       .|. |||||| .|... ||.|        .|| .|||  . .
knrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPld.......ntladfWrmiweyncstivllt......kdkcsqywplkivi

TERYGEVDVKLVCELEEktWVHREFDVSptssyssstkssrksRASRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVR----GRQYTSPIVVHCSA
.|  ..|.|..| | ||  .| |....|               . ....   |. |. .. | | |     .... .. .||      .  ..|||||||
keerfkvkvdsveesee..yvvrdiels...............edgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsa

GIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGE
|.|||||.|. | ...|.. |  .|..  |.  ||||...|  . ||  ||  . |
gvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 137-417 4.4e-48 158.5 In-house 16-294 (301) alignment 
Range on Protein: 137-417
Range on HMM: 16-294/301.0
RrrlLQDEFLVLSRTEARRLTRSTDRatRHAAANRYSDIVPYDHTLVELD--------TGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWR
.   .....  |...| .. | ...   ...|.||. .|..||.  . |         . .|||||...| |.....||.|||.       |.|. ||||
k...feeqykelkegedksctvglse..enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpm.......kktlvdfWr

MIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLVCELEEKTWVHREFDVSPTSSySSSTKSSRKSRASRQQSHMKVSQWQYKEWKDTG
.|.|. .. |||. . .|.  .|| .|||..  ..|..|.. |.|| |     .| |.. |  . . |. ..  || . ....| ..| |.|  .| . |
liwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdg.snngyierkfkvksdksswdvlqlqvtdWpqdG

GAPRIANFLEFLLQVRGRQY---TSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
  .  .  |. . .|  ||     .|.|||||....|.||..  .  .    .||..|.|  ... |...| .| | .||  |||.| .||.
vvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_PTPN13_pd Subfamily PTPN13 143-416 1.9e-46 153.6 In-house 15-269 (273) alignment 
Range on Protein: 143-416
Range on HMM: 15-269/273.0
DEFLVLSRTEARRLTRSTdRATRHAAANRYSDIVPYDHTLVELDT-GDYINASFVQGE--SDATRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIV
.||  |    .   .... .  .. ..||| ...|||.| |.|.  | |||||... .   |  . ||.|||.        |||.|||.|. . ..  |.
eefkelrelkpldtcevg.kkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlP.......etvkdfwqmvweqkaevia

MLGQHQEDFVQKCGEYWPSAMGKTERYGE-VDVKLVCELEEKTWVHREFDVSptssyssstksSRKSRASRqqshmKVSQWQYKEWKDTGGAPRIANFLE
|. ...|.   ||  |||. ..|.    . ..|.|.   . ...| |.. |.             .|..||     .|.. .. .| | |     |..|.
mvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk...........dsesgesr.....evahlnfvkwPdhgvPssaaellq

FLLQVRGRQY-TSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYL
|. .||  |  ..||||||||||||.|..|. | |.   | .  .|.   |.. |.|| ..| | .||  .| .| | |
fvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 162-414 1.2e-45 150.8 In-house 45-277 (315) alignment 
Range on Protein: 162-414
Range on HMM: 45-277/315.0
RATRHAAANRYSDIVPYDHTLVEL------DTGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEY
. .     ||| .|..||.. |.|      .  ||.||.|..| .   |.||.|||         ..| ||||.. ..|.. |||| .  |.  .|. .|
kkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn.......vasvkdfwrlvfeedigkivmltnlvegekrkaeky

WPSAmgkTERYGEVDVKLVCELEEKTWVHREFdvsptssyssstkssrkSRASRqQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQ--YTSPIV
||        ||.. | .. |  .. .  | .                 |  .. .   .| |..|  | |.| .    .....  .|.  .    ..||
wpdk...kviyGkitvtrkseevnteytvrtl.................svvfg.dnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaiv

VHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGE
||||||.|||| ||. | |. . | | .||..  ... ||.|  || ...||. |||.. |
vhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPN9_pd Subfamily PTPN9 137-417 9e-45 148.0 In-house 14-291 (297) alignment 
Range on Protein: 137-417
Range on HMM: 14-291/297.0
RRRLLQDEFLVLsRTEARRLTRSTDRATRHAAANRYSDIVPYDHTLVEL------DTGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMI
..| |. |.. . | |.   |  . .       |||.|.. ||.| | |      .. |||||.||.|      .||||||.       |.||||||||.
gkrGlskeyaei.rnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGpl.......kktvsdfWrmv

VQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLVCELEEKTWVHREFDVSptssySSstkssrKSRASRqqshmKVSQWQYKEWKDTGGA
 . .|  |||  .  |    |||.|||.  ......|.. |. |   ||. ...| . ..      .      | . ||     ||. .|.  | | |  
WeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleik.....nv......kteesr.....kvthfqflsWPdyGvP

PRIANFLEFLLQVRGRQYT---------------SPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEY
   |..|..| .|| .| .                |||||||||||||| ||  |  .||.|..| .|..  |.. |.||  .. | .|||  |  . ||
ssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

LR
  
al
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 162-419 1.7e-44 146.8 In-house 16-267 (270) alignment 
Range on Protein: 162-419
Range on HMM: 16-267/270.0
RATRHAAANRYSDIVPYDHTLVELD------TGDYINASFVQGESD-ATRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGE
 |.|... ||| ||.|  .| | |.      .  |||| .|.| ..  ...||..|| ..       |...|||||..  | .|||. . .|.  .||  
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpt.......tlksfwrmiweekvtaivmttgleEkgrkkCer

YWPSAMGKTERYGEVDVKLVCELEEKTwvhrefdvsptssyssSTKSSRKSRASRQQSHMKVSQWQYKEWKDTGGAPRIA------NFLEFLLQVRGRQY
|||.  ... .. . ..| . . |||.                .    .. |  .. .. ..  ..|..| | |  ..        . |. | .||  . 
YWpaepkekvkledgkikvlalseeke................egyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsek

T----SPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRNY
     .|..||||||.||||..| .| ..   |... .|. . ... |..|. .| ...||| .|  . || .  
eldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 166-416 5.1e-44 145.7 In-house 48-288 (325) alignment 
Range on Protein: 166-416
Range on HMM: 48-288/325.0
HAAANRYSDIVPYDHTLVELDT------GDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQhQEDFVQKCGEYWPSA
  | ||. ..|..|.. | | |       ||||||... . .   ..|.| |         .|. |.||.....  . .|.| .  .   ..|  |||  
nkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPl.......tatindlWrlvldWrcsvvvvlne.ldlgkdrcavywpke

MGKTERYGEVDVKLVCELEEKTWVHREFDVSPTSSysSSTKSsrksrasrqqshmkVSQWQYKEWKDTGGAPRIANFLEFLL---QVRGR-----QYTSP
|||. ..| ..|||..  |   .||| .||  ..     |.|              | |.|.. |.| |   | | .. .|    .|  |     . ..|
mgksktfGglevklrtieeisdyvhrvldvkqvkk..Getrs..............vkqfqlqswddmGvqkrpatlisilqlvkavservtantkastp

IVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYL
|.||||||.|||||||.   .. .   |  .|||  |.. |..||||| || ||  ||. . |..
ilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_CG7180_pd Subfamily CG7180 161-416 1.3e-42 140.5 In-house 37-290 (296) alignment 
Range on Protein: 161-416
Range on HMM: 37-290/296.0
DRATRHAAANRYSDIVPYDHTLVELDT------GDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQhQEDFVQKCGE
.  .     ||. ..||||.. | |..       |||||..|..      .| |..|        |||| .|||.. . .. ..|.| . . || ... .
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapk.......ketvdefWrlvydeeisavvvLtk.tfdfakmyps

YWPSAMgkTERYGEVDVKLVCELEEKTWVHREFDVSPTssysssTKSSRKSRASRQQSHMKVSQWQYKEWKDTGGAPRI-ANFLEFLLQVR---GRQ---
|||  .   |.|||. |..| | .    . |.| .  .        .  . ..  .     | . |..||.     | . . ..|.. .||   ..    
ywpnks..keqygeifveiveekqyanlkirtfkltkk......ivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvded

-YTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYL
  ..|.||..| | .|.||..  |  .   | |. .|.|  | . |..|| .| .|..|  |||.. |..
peegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_PTPN14_pd Subfamily PTPN14 158-418 8.8e-42 138.1 In-house 41-298 (300) alignment 
Range on Protein: 158-418
Range on HMM: 41-298/300.0
RSTDRATRHAAANRYSDIVPYDHTLVELD-----TGDYINASFVQGE--SDATRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGQHQEDFVQ
 || .    |  ||. |..||... |||      . .||||| ..    .    .|..|||..        || |||.|. . .|. |||| ...||  .
lstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPle.......ltvqdfWqmvWeqgvqlivmlteeeedgke

KCGEYWPSAMGKTERYGEvdvklvceleEKTWVHREFDVSpTSSYSSStKSSRKSRASRQQShmKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGR----
|. .|.|.   | ..             .|  |  .|  . ..|.  . .   |   |...   .|   ||..| | |  . . .||..| .|.      
ksfkyfPkleskkktvef..........gkfkvttkfsed.sdsvitt.glklkhlpskeer..tvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

-------QYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRN
       .   |..||||||.||||| | .| .|. .| .  ||| . ..| |.|| ..| |. ||. .|... .||.|
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_PTPN1_pd Subfamily PTPN1 149-412 4.8e-41 135.4 In-house 15-267 (290) alignment 
Range on Protein: 149-412
Range on HMM: 15-267/290.0
SRTEARRLTRSTDRATRHAAANRYSDIVPYDHTLVELDTG--DYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQE
 | ||. .. .. .  .  . ||| |. ||||. ..|. .  ||||||.|. |    ..| ||||.        .||. ||.|. . .  ..||| .  |
irkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPl.......pntvdhfWqmvWeqkskavvmlnkvve

DFVQKCGEYWPSAMGKT-ERYG--EVDVKLVCELEEKTWVHREFDVSPtssyssstkssrksraSRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQV
   .|| .|||.   .    .   .. |||. | ...... | ...                   . |   ..... |  | | |     |.||.|| .|
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen................lktqetreilhfhyttwpdfgvpespaaflkflfkv

RGR----QYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGI---IDIFSEVNRSRQQRPSMVYTVKQYECIYDII
|      .   | |.||||||||.| |.  | .. . | ..    .||   .   |..|  .. | .| .  |  |
resGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_PTPRN_pd Subfamily PTPRN 118-414 1.3e-40 134.0 In-house 8-290 (297) alignment 
Range on Protein: 118-414
Range on HMM: 8-290/297.0
ETDYSADSFLASMTKESTNRRRLLQDEFLVLSRTEARRLTRSTDRATRHAAANRYSDIVPYDHTLVELDT------GDYINASFVQGE-SDATRWIATQG
. | |.   . |  ..  . .  |. |.  | . ||   |... .| . .  ||.....||||. |.|..       ||||||..  .   |. .|||||
nldistGhvvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqg

PIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAmGkTERYGEVDVKLVCEleeKTWVHrEFDVspTSSYSSSTKSSrKSRasrq
|. |       ||.|||.|. .  |. ||.| . .|. |..| .|||   | .| |.  .|.|| |   . | . .. |   | |    ..| ..|    
plas.......tvadfwqmvweqGvvvivnltrleeegvkqckrywpde.G.sevyhiyevhlvse...hiwcd.dylv..rsfylknlqts.etr....

qshmKVSQWQYKEWKDTGGAPRIANFLEFLLQVRG--RQYTSPIVVHCSAGIGRTGVFICTDNVISRFEsEG--IIDIFSEVNRSRQQRPSMVYTVKQYE
     |.|. .  |...|  .   ..|||  .|    |  ..|||||||.| |||||.|  | |..|.   |   ||| . ..  |.||| .| | .|.|
....tvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfe

CIYDIIGE
 ..  . |
faltavae
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 138-417 2.9e-40 133.0 In-house 5-260 (267) alignment 
Range on Protein: 138-417
Range on HMM: 5-260/267.0
RRLLQDEFLVLSRTEARRLTRSTDRATRHAAANRYSDIVPYDHTLVELDT--GDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDV
.. .. ||  . .    . | |.  |.  .. ||. | .|||.| | | |   .|||||.|.|      .|.||.|.       | |..||. .| ...|
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdpl.......kntitdfltvihdqkv

ACIVMLGQHQEDFVQkcgEYWPSAMGKTERYGEVDVKLVCELEEKTWvhrefDVsptssyssSTKSSrKsraSRQQSHMKVSQWQYKEWK-DTGGAPRIA
. ||.| .  .| ..    .||  ||....| .. |.   | ||. .     ..         |    |    ...|  .|. . ||.|. .|   | . 
pvivlltkvftdnir...lfwPPkmgqakkyqdltvehslekeendy.....qi........itlel.k...fknesahnvtlyyykkwnintnnkpylk

NFLEFLLQVRGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
 ..  | . .  .   |.||.||.|.||.| |.  |  . |   ||. |||  . . |.||...| |  .|  |.... || .
plfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
0041856 (Phosphotyrosine protein) phosphatases II 169-417 8.3e-40 131.7 In-house 4-172 (182) alignment 
Range on Protein: 169-417
Range on HMM: 4-172/182.0
ANRYSDIVPYDHTLveldTGDYINASFVQGESDATRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGqhqedfvqkCGEYWPsamgkteryge
 ||||||.||||..      |||||... |   |||.|||||| .|       || ||.||. .... .||.|          .  |||           
knrysdilpydhsr....dldyInanlylgslpatrfiatqgplls.......tvadflrmlkelgittivnlt.........eelywp...........

vdvklvceleekT-WvhrefdvsptssyssstkssrksrasrqqsHMKVSQWQYKEWKDTGGAPrIANFLEFLLQVRGrqYTSPIVVHCSAGIGRTGVFI
            . .                              .  . |..|  | | |  . .  .|.|. .|.      |..||||||.||||...
............ell..............................erlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlv

CTDNVISRfeseGiIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
. . ....    | ..... |.  |..|| || |  ||  ..... |.|.
aaylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 163-418 2.3e-39 129.9 In-house 35-279 (287) alignment 
Range on Protein: 163-418
Range on HMM: 35-279/287.0
ATRHAAANRYSDIVPYDHT--LVELD---TGDYINASFVQGESDATRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWP
 .  .  |||.|..|.|.|  |.  .     ||||| .| .  |  ..||.|||| .       || ||||....  .| .... .  |.  .|| .|||
elaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaa.......tvrdfwravletrsasvitmtreveearlkcykywP

SAmGKTERYGEVDVKLVcelEEKtWvhrefdVSPTssYssSTKSSRKSRASRQQSHMkVSQWQYKEWKDTGGAPRIANFLEFLLQV-------RGRQYTS
    .  | |   | |.   . .         .|   |  .... |   .  ..... | | .. .| | . ||    .. | |.|       |  . . 
er.evPmrvGGysvvll...dyd.i......kePe..y..gvralrlidletrearv.vkqldllswPdkvlaPtavglirfvldvkqhielardasevG

PIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRN
|.|||...||||.|... |  ..|| |. | .|.   | | |..| ..| .| |.  .|. .  | . 
PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
0051429 (Phosphotyrosine protein) phosphatases II 185-419 2.7e-39 130.8 In-house 1-228 (272) alignment 
Range on Protein: 185-419
Range on HMM: 1-228/272.0
LDTGDYINASFVQGEsdaTR------WIATQGPIDSgecigkeTVSDFWRMiVQYDVACIVMLGQHQEDFVQKCGEYWP----------SAMGKTERYGE
|....||||..| |    .|       ....|| .        |. ||||.  .... .||.| .  |   .||  |||          . .  | .|| 
lplsgyiNardvggy...grvvkpgrlyrsggplpl.......taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilyga

VDVKLVCELEEKTWVHREFDVSPTSSyssstkssrksrasrQQSHMKVSQWQYKEWKDTGGA-PRIANFLEFLLQvrgrqyTSPIVVHCSAGIGRTGVFI
. |.|..|     ...||. .. ..|                .  ..| ...|  | | | .   . ..||.||.        |..||||||..|||...
lrvtllseellldyilrellltllls...............agearevmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvv

CTDNVISRFESEGIID--------IFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRNY
. . .. ... | |.|        ..  |.. |.||| .| |  ||...|... |.||..
allllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 138-415 3.6e-38 126.0 In-house 19-235 (392) alignment 
Range on Protein: 138-415
Range on HMM: 19-235/392.0
RRLLQDEFLVLSRTEARRLTRStdRATRHAAANRYSDIVPYDHTLVEL------DTGDYINASFVQGESDATRWIATQGPIDSgecigkeTVSDFWRMIV
  |. .||  |   .. . | .  .       ||| .|.||| . | |         ||.|||....      .||.|||  .       ...|||||. 
salffeefhdlpgpdiypqtva..qkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa.......slddfwrmvf

QYDVACIVMLGQHQEDFvqkcgeywpsamgkterygevdvklvceleektwvhrefdvsptssyssstkssrksrasRQQSHMKVSQWQYKEWKDTGGAP
| .|. |.|. . .|                                                              . ...  |.|... || | .   
qenvttiamvtklkegd............................................................kgddartvaqfhftewPdkdvpk

RIANFLEFLLQVRG--RQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEY
. ...|.|. .|.    ||| |...|||||.||||| |. |.|... .   ..|.|  |   |..|| || | .||  ||  . | 
htssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
0036282 (Phosphotyrosine protein) phosphatases II 188-410 6.6e-37 122.2 In-house 2-164 (174) alignment 
Range on Protein: 188-410
Range on HMM: 2-164/174.0
GDYINASFVQGESDATRWIATQGPIDsgecigketvsdFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSamgkterygevdvklvceleektwvhref
 ||||||.. .    .|.||.||| .            ||.|. .... ..||| . .|.   ||  |||.                             
sdyinaspldlsyitprliagqgpla............fwemlkelgittvvmlleekelglykcinywpe.............................

dvsptssyssstkssrksraSRQQSHMKVSQWQYKEWKDTGGAPRIAnFLEFLLQVRGRQY---TSPIVVHCSAGIGRTGVFICTDNVISRFEsEGIIDI
                     |.  .  . |..|  | | |  .    .|||. .|.  .      |..||||||.||||.... . .. . . |. .|.
....................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvda

FSEVNRSRQQRPSMVYTVKQYECIYD
.. | . |.||| ||.|  ||. .|.
ldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 125-415 7.8e-36 118.5 In-house 6-278 (439) alignment 
Range on Protein: 125-415
Range on HMM: 6-278/439.0
SFLASMTKESTNRRRLLQDEFLVLSRTEARRLTRSTDRATRHAAA-NRYSDIVPYDHTLVEL------DTGDYINASFVQGESDATRWIATQGPIdsgec
 |   . |   |.. .....|  .. |.      ..  |  .  . ||| |....||| | |          |||| ...|  |   .||||||      
efqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpk.....

igKETVSDFWRMIVQYDVACIVMLGQHQEDFVqkcgeYWPSAmgKTERYGEVDVKLVCELEEKTWVHREFDVsptssYsSSTKSSRKSRAsrqqshmkVS
  |||. ||||....  .. |||| .  | .      ||||   .   ||.. |.   ..|   .| | | |     .     ...| |.        | 
..kettddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavrvdrnielpnyvirgfkv.....f.nerdttekert........vl

QWQYKEWKDTGG---APRIANFLEFLLQVRGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGE
|..|  | |      |  . .||  .     .. . |.|||||||.||||  |. |  . .. .|  .||   |.  |.||  || .. ||  ||. . |
qfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

Y
 
d
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 141-418 8.9e-34 111.6 In-house 24-289 (305) alignment 
Range on Protein: 141-418
Range on HMM: 24-289/305.0
LQDEFLVLSRTEARRLTRSTDRATrHAAANRYSDIVPYDHTLVELDT---GDYINASFVQGESDATRWIATQGPIDsgecigkETVSDFWRMIVQYDVAC
|. ||  . | .     ..   |  .|  ||| |.   |.  | |..    .|| | .|   ... |.| || |..       .| .||| | .|  |  
lraefvamkrfndfekmkafkeaq.eagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaple.......ktcadfwymclqdkvea

IVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLVCELEEKTWVhrEFDvSPTSSYSSSTKSSRKsraSRQQSHMKVSQWQYKEWKDTGGAPRIANFL
| || . .|   .|| ||..|  ...  . | . |..  .|  . .  .|  .....  . |.   .      ..  ||... . .| | |  .     |
ifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtl..kfr.kdakakvtetvlvie...gpgekarkvthyhwidwpdrgvpaadlail

EFLLQVrgRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSE-VNRSRQQRPSMVYTVKQYECIYDIIGEYLRN
|.| .   |    ||||||||||||||  .  . .. .. .  ||.     ... |.||   . | .||  ....| .|.|.
elleka..rpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 167-412 1e-33 111.5 In-house 4-235 (237) alignment 
Range on Protein: 167-412
Range on HMM: 4-235/237.0
AAANRYSDIVPYDHTLVELD----TGDYINASFVQGES-DATRWIATQGPIDSGeCigketvSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAmG
 . |||..|| |||. | |     . |||||....|      ..||.|||..|  |       |||.|. |   . ||||    |   .|| .||||.  
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgpless.c......ddfwqmvwqekcsvivmltgliegnelkchkywpst.d

KTERYGEVDVKLVCELEEKTWVHREFDVSPTSSYSsstkssrksrasrqqSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQ----YTSPIVVHCS
. . || . | |  . |   .  | . .|   .                     . |.|.  | | |   . | .| |  ..  |      ..| ..|||
qpaaygvltvslkkkeefsdytvrslllskrltlk...............evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcs

AGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDII
||.||||.|.  | .. . . . ..||.  |    ..|| .. |  ||  |.. |
agvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0043147 (Phosphotyrosine protein) phosphatases II 187-409 5.2e-33 109.6 In-house 4-154 (172) alignment 
Range on Protein: 187-409
Range on HMM: 4-154/172.0
TGDYINASFVQGESDATRWIATQGPidsgeciGKETVSDFWRMIVQYDVACIVMLGQHqedfvqkcgeywpsamgkterygevdvklvceleektwvhre
  ||||||.. .    .|.||||||       . .|..|||||. .... .||.| ..                                          
gsdyinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgithivnltel..........................................

fdvsptssyssstkssrksRASRQQSHMKVSQWQYKEWKDTGGApRIANFLEFLLQVRG---RQYTSPIVVHCSAGIGRTGVFICTDNVIsrfesEGIiD
                      ... .  . |..|  | | |    .. .|||| ...    ..   |..||||||.||||.... . ..     .|. .
...................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.s

IFSEVNRSRQQRPSMVYTVKQYECIY
..  |.  |..|| .|..  || ..|
leeavalvrekRpgavqnpsqyrfly
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 159-415 7e-32 105.2 In-house 49-282 (290) alignment 
Range on Protein: 159-415
Range on HMM: 49-282/290.0
STDRATRHAAANRYSDIVPYDHTLVELD---TGDYINASFVQGESdaTRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEY
.   .  .   ||| |.|  | | | |.    |||. | .|.|    . .| |||..       |.|| |.|||..| .|| |||| .  ||   || .|
kifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGal.......kdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPSAMGKTERYGEVDVklVCELEEKTWVHREFDVsptssYSSSTKssrKSRASRQQSHMKVsqwqyKEWKDTGGAPRIANFLEFLLQVRgrQYTSPIVVH
.|   |..  .||. |  .| .|..   .    .      |   |   .|  . .  |.|.     | | |   |     .|  |  .|  . . |.|||
ypekeGevltfGeitv..lcseeddkdaniikkt.....lsvrdk...dsGkehklkhlki.....kswpdksvalstlallrtlrilr..kasGpvvvh

CSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEY
||||||||| |.  .  .  .     .|.   |   |. | . |    ||  . .|. ..
csaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 165-421 1.5e-31 104.2 In-house 54-295 (305) alignment 
Range on Protein: 165-421
Range on HMM: 54-295/305.0
RHAAANRYSDIVPYDHTLVELDT---GDYINASFVQGES-DATRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAM
   . |||.|.   |...| ||     ||| | .|        |.|..|||.|       .|. .|| |..|  |  |||| .  |    || .||| |.
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpld.......qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

GKTErygevDVKLVCEL---EEKTWVHREFDVSPTSSyssstkssrKSRASrQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQytSPIVVHCS
|.       ..|  . .        ..|. ..  |           .   |  . .| | . |. || | |  |     ||.|  .|| .   |||||||
gekl.....elksgivvenvsgskpmerdaeiqitll.........nltys.gdqkmsvrhlqwtewpdrgvppckltslellsairgsk..vpivvhcs

AGIGRTGVFICTDNVISRFESEGIIDIFSE-VNRSRQQRPSMVYTVKQYECIYDIIGEYL-RNYHQ
|||||||  .. . .. .   .     . | |.  |.||   . .  ||  |. .. .|.  .|..
agigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 140-421 2.1e-31 104.1 In-house 17-282 (307) alignment 
Range on Protein: 140-421
Range on HMM: 17-282/307.0
LLQDEFLVLSRTEARRLTrsTDRATRHAAANRYSDIVPYDHTLVELD----TGDYINASFVQGESDATRWIATQGPIDSgecigkeTVSDFWRMIVQYDV
 |.||| ||.. .   .|  ..  .  .  |||.|.   |.. . .     . ||| | ..    .  ..|..||| ..       |. .|| |..| .|
alvdefrvlakktpegvt..veafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplen.......tqysfwamaiqekv

ACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKL-VCELEEKTwvhrefdVSPTSSYSSSTKSsrksRASRQQSHMKVSQWQYKEWKDTGGAPRIA
 ...|| .  |    || .|||   |..  .||    . | .|  |.       ..|   .   |.     .    |    ....|...| | |  .   
esvimlckvielakikceqywpleegqklvfgeapntisvanlgakk.......lapdedlinvttl....kvdwaqksrtiqhlqwenwpdrgvpqinl

NFLEFLLQVRGrqYTSPIVVHCSAGIGRTGVFICTDNVISRF-ESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRNYHQ
. ...|  ||.   | |.|||||||.||.|  ..   |  .  . .   |.   |.  |.||.  . |  ||  .. .. ||. . ..
tainlleavry..dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyk
0046846 (Phosphotyrosine protein) phosphatases II 189-418 2.5e-31 104.2 In-house 13-175 (176) alignment 
Range on Protein: 189-418
Range on HMM: 13-175/176.0
DYINASFVQGEsdatRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTErygevdvklvceleektwvhrefd
|||||... |     |.||||||. .       |. ||..|. .... ..|.| ...|    ||  |||  ..                           
dyinanlilgs....rpiatqgplpr.......tladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

vsptssyssstkssrksrasrqqshmkvsQWQYKEWKDTgGAPRIANFLEFLLQVRGRQYTS-PIVVHCSAGIGRTGVFICTDNVISrfesEGIIDIFSE
                             |...  | |  |.| .. .||.| ..| ..    |..|||||||||||.... . ...    |  ....  
.............................qylhlpwpDh.gvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveea

VNRSRQQRP-SMVYTVKQYECIYDIIGEYLRN
. . |.|||  .| | .||. .|. . ..|..
lalvreqRplgavqtpeQyrflyefellllkk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 166-416 4.1e-30 99.7 In-house 47-344 (350) alignment 
Range on Protein: 166-416
Range on HMM: 47-344/350.0
HAAANRYSDIVPYDHTLVELD--------------TGDYINASFVQGE------SDATRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQ
  | |||..|.||.|. |.|               | |||||.... .          ..||||.|. |       || ||...|.. .|  |..| . .
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlps.......tvddfykvillnkvkvilsltsdv

EDFVQKCGEYWPSAmgkteRYGEVDVKLVCELEE----KTWVHREFDVSPTSSYSS--STKSSRKSRASRQ------QSHMKVSQWQYKEWKDTGGAPRI
|  ..|| .||.        | .. |||    |.    .  . . .||  ..|     | .   |   |           . | | |.| ||| .   . 
elnlekcyrYWqeg.....sydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnP

ANFLEFLL-------QVRGRQY-----TSPIVVHCSAGIGRTGVFICTDNVISRFES--------------EGIID-IFSEVNRSRQQRPSMVYTVKQYE
 ..|. |        .   ...     .|||.||||||.||||...  | ..| ||                 . | |.  ||. |.|| ||| ...|. 
esilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfi

CIYDIIGEYL
 ||. .  | 
fiYeallfyf
0049260 (Phosphotyrosine protein) phosphatases II 214-410 5.2e-30 99.5 In-house 13-144 (152) alignment 
Range on Protein: 214-410
Range on HMM: 13-144/152.0
SGECIGKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWpsamgkterygevdvklvceleektwvhrefdvsptssyssstkssrksrasrqqsh
 .. .| .|..|||||. .... .|||| ...|.   || .|.                                                         
atqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................................

mkvsQWQYKEWKDTGGAPRIANFLEFLLQVRG--RQYTSPIVVHCSAGIGRTGVFICTDNVIsrfeseGIIDIFSEVNRSRQQRPSMVYTVKQYECIYD
    |...  | | |  . .  .|..|| ..   ..   |..||||||.||||.... . ..        ....  |.. |..|| .|..  |.. .|.
....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 188-405 8.9e-30 98.5 In-house 73-270 (301) alignment 
Range on Protein: 188-405
Range on HMM: 73-270/301.0
GD--YINASFVQGESDATRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLVCE--LEEKTWV
|    | | ... . .. |.||||||..       .|  ||| |.|||||  ||||||. |. ..|| || |. .... . |  ..|.. .  . .|  .
GkrvPihanwiptsGhphrfiatqgPlk.......ntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkis

HREFDVSPTSsyssstkssrKSRASRqqshmKVSQWQYKEWKDTGGAPRIANFLEFLLQVrgRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIID
.|...|  ..          .  |.|      |  .||.|| | |     |.  ...  |  ..   ||||||||||||.  || |. . .. |..  |.
krtlevedst..........gkfatr.....tvthyqysewtdrgvPkshaelfdlmelv..kksekPivvhcsaGiGrsvafigteylareveadptie

IFSEVNRSRQQRPSMVYTVKQY
.   ... |..| . | |..| 
ltealkhlrehrwngvqtnsql
0049772 (Phosphotyrosine protein) phosphatases II 158-419 4.1e-29 97.7 In-house 38-283 (314) alignment 
Range on Protein: 158-419
Range on HMM: 38-283/314.0
RSTDRATRHAAANRYSDIVPYDhTLVELD-----TGDYINASFVQGEsdaTRWIATQGPIDsgecigkETVSDF----------WRMIV--QYDVACIVM
. . .  ..   ||| ||.|.| ..| |.     . ||||||.| |     ..|||||| .       .|| ||          |||..  ...|  |||
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgple.......itvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------LGQHQEDFvqkcgeywpsamgkterygevdvklvCEL--------EektwvhrefdvsptssyssstkssrksraSR--
                     | .  . .                          .|.        .                             ..  
srdevladelsrLdaAlgKtpllildgng..........................neptaadlellk.............................eely

----QqsHMKVSQWQYKEWKDtGGAPRIANFLEFLLQVRGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFeseGIiDIFSEVNRSRQQRP-----SMVY
          . .. .  . | |.|| .. |.|||  ..  .  .|..|||.||.||||.|.... .....   |. ..   ... |..||     ....
dpelf..erlgikylripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfie

TVKQYECIYDIIGEYLRNY
. .||| |.... |||...
qleqyefilealleylkfl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 167-409 4.4e-29 96.3 In-house 9-234 (239) alignment 
Range on Protein: 167-409
Range on HMM: 9-234/239.0
AAANRYSDIVPYDHTLVELD------TGDYINASFVQGES-DATRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSA
 | |||..|| |||. | |.        ||||||...        .||||| .         .  |||||. |   . ||||    | . .|| .||| .
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcvei.......ssgdfwrmmwqerrcvivmltglieghkkkchqywpds

mgkTERYGEVDVKLvceleEKTWVHREFDVSpTSSYSSSTkssrksrasrQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRG--RQYTSPIVVHCS
   | .| .. | |      || |  .. .  |   |             |     | |...  | | |     .  | .  ..       . | |.|||
...tskycnlrvtl.....rktevfadyiir.tfvmsqvg..........qteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcs

AGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIY
||.|||| |.  | .. . . .  .|||  |.  |..|| || | .||  |.
agvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 167-409 4.6e-29 96.3 In-house 8-233 (239) alignment 
Range on Protein: 167-409
Range on HMM: 8-233/239.0
AAANRYSDIVPYDHTLVELD------TGDYINASFVQGES-DATRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSA
 | |||..|| |||. | |.        ||||||...        .||||| .         .  |||||. |   . ||||    | . .|| .||| .
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcvei.......ssgdfwrmmwqerrcvivmltglieghkkkchqywpds

mgkTERYGEVDVKLvceleEKTWVHREFDVSpTSSYSSSTkssrksrasrQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRG--RQYTSPIVVHCS
   | .| .. | |      || |  .. .  |   |             |     | |...  | | |     .  | .  ..       . | |.|||
...tskycnlrvtl.....rktevfadyiir.tfvmsqvg..........qteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcs

AGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIY
||.|||| |.  | .. . . .  .|||  |.  |..|| || | .||  |.
agvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 161-417 7.4e-27 89.1 In-house 38-272 (288) alignment 
Range on Protein: 161-417
Range on HMM: 38-272/288.0
DRATRHAAANRYSDIVPYDHTLVEL--DTGDYINASFVQGESDATRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPS
|     .. .|| ..   | | | |  |.  ||.|  |  .    | | .| |...       |.  .|.|... ||  |||| .  |   .|  ||.||
dsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlng.......tieelWkmllesdveyivmlcellekGkeksaeyfPs

AMGKTERYGEVdvklvCELEEKTWvhreFDVSPTSSYSSstksSRKSRASRQQSHMKVSQWqyKEWKDTGGAPRIANFLEFLLQVrgRQYTSPIVVHCSA
 .|.. |.| .     |    |       |.  . . |      | |.   ..  .|.  .  .||.| |       .| .|  .  .... |||||.||
klGekarigrl.....ctvvkkkr....adidklvkvsl....lriskegeekvivkilhl..leWdddgvPenylsplrllevl..kslqkPivvhssa

GIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLR
|.|||| .| .  ..    ..  . | | ... |..|   . | .||  .. .. |.| 
GvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
0044763 (Phosphotyrosine protein) phosphatases II 178-415 1.9e-26 88.2 In-house 2-170 (178) alignment 
Range on Protein: 178-415
Range on HMM: 2-170/178.0
YDHTLVELD------TGDYINASFVQGEsdatRWIATQGPidsgecigketvSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGkterygevdv
.|.|.| |.      ..||||||.. .      ......|            .|..... .... .||.| . .| . .|| .|||. .|          
ldrtrvllsnleglersdyinaseilpg....lylgslpp............addlellkelgithivnlteelelgflkcdpywpeeag..........

klvceleektwvhrefdvsptssyssstkssrksrasrqqshmkvSQWQYKEWKDTGGAPRIANFLEFLLQVRGR--QYTSPIVVHCSAGIGRTGVFICT
                                              |...  . | |  . .. ||||.  ..    .  .|..||||||.||.|.... 
.............................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaa

DNVISRfeseGIiDIFSEVNRSRQQRPsMVYTVKQYECIYDIIGEY
. ....    |. .... ... |..|| .|..  |.. .|..  ..
ylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefelrl
PTPc_DSPc_SM00012 315-412 5.1e-26 86.3 In-house 1-103 (105) alignment 
Range on Protein: 315-412
Range on HMM: 1-103/105.0
KVSQWQYKEWKDTgGAP-RIANFLEFLLQVRGRQYT----SPIVVHCSAGIGRTGVFICTDNVISRFESE-GIIDIFSEVNRSRQQRPSMVYTVKQYECI
.|.. .|..|.|. |.| .  ..||.| .|.  ..     .|.|||||||.||||.|.. | .....|.| . .|||  |.. |.|||.|| |  ||  .
tvkhyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YDII
|...
yral
0051082 (Phosphotyrosine protein) phosphatases II 189-411 5.9e-26 86.3 In-house 4-148 (151) alignment 
Range on Protein: 189-411
Range on HMM: 4-148/151.0
DYINASFVQGEsdatrWIATQGPIDsgecigketvsDFWRMIVQYDVACIVMLGQHQEDFvqKCGEYWPSAMgkterygevdvklvceleektwvhrefd
||||.|.| |       ....|| .           ||.... .... .||.| . .|    .| ||.|..                             
dyinfsyvtgg.....lyrsggpla...........dflellkelgiktivnlrseeerg..ycpeylpelg............................

vsptssyssstkssrksrasrqqshMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGrQYTSPIVVHCSAGIGRTGVFICTDNVISRfesegiIDIFSEV
                         ..| ....  |.|.|    .. .|||| ...  .   |..||||||.||||.... . .. .      ..... .
.........................ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleeal

NRSRQQRPSMVYTVKQYECIYDI
.  |..|| .|..  |. ...  
eeyrlkrpgvvqpnqqflfqlfa
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 168-416 2.8e-25 83.8 In-house 37-270 (285) alignment 
Range on Protein: 168-416
Range on HMM: 37-270/285.0
AANRYSDIVPYDHTLVELDT--GDYINASFVQG-ESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTE
  |||.|.   . | | |     ||| ||...    | . .|.||||.        ||.||||.|| |  .| ..||    |  |.||  |.|  .|.  
dlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgpl.......petlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

RYGEVDVKLVcELEEKTWVHREFDvSPTSsysssTKSSRKSRASRQQSHMKVSQWQYKEwKDTGGAPRIaNFLEFLLQVRGRQytSPIVVHCSAGIGRTG
..|. .. |  | .|..     .. . |      ...   |       |..|  |  .        | | .. ... .|  ..   ||.||||||.||| 
kfgkyeitlt.eckeeaiagtiln.altv.....intedasseplymnhvqvpwwpdql.apedarpmi.elykwvkkvnpke..kpicvhcsagvgrta

VFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYL
 |.  |    |   .  |...  |   |  |   | .  |.  .| .. ||.
tfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 163-408 7.5e-25 82.1 In-house 49-282 (310) alignment 
Range on Protein: 163-408
Range on HMM: 49-282/310.0
ATRHAAANRYSDIVPYDHTLVELD-----TGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWP
 ...   |||||.|  | . | |       .||| | .|. .   . .| .|||.       . |. |||||| |     |..| .  |.   ||  |||
ykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgpl.......qhtiidfwrmifqeraesilllckvgeegrpkcvgywp

SaMGKTERYGEVDVKLVCELEEktwvhrEFDVSPTSSYSSSTK-SSRKSRAsrQQSHMKVSQWQYKEWKDTGGAPRIANFLE--FLLQVRgrqyTSPIVV
| .| || || . |  ..|  |      ||..   .      .    .  |  .  ...||  .. .| |.|        .   .| |||      | ||
s.lgvtetygcirvtnlsesse......efeicnlavtfvpdnvpvdeqpa..nlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr....hgpcvv

HCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECI
|||||..|..| .  .  | . .    .|.   .   ...|   . |  ||  |
hcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii
subfamily_ptpA1_pd Subfamily ptpA1 142-370 1.5e-23 78.2 In-house 24-249 (418) alignment 
Range on Protein: 142-370
Range on HMM: 24-249/418.0
QDEFLVLSRTEARRLTRSTDRAtRHAAANRYSDIVPYDHTLVELD------TGDYINASFVQGESdATRWIATQGPIDsgecigkETVSDFWRMIVQYDV
..|| .|  .     |   |.  . .. |||..|.| .|| |.|         ||||| ...|     ..|.||||.        .|..|||||. .  .
keefrlleesvgpsetsegdkk.hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplp.......ntiadfwrmvwenrc

ACIVMLGQHQEDFVQKCGEYWPSAMGKTE--RYGEVDVKLvceleeKTWVHREFDVSPTSsysSSTKSSRKSRASRQQSHMKVSQWQYKEWKDTGGAPRI
  |||| .  |.   ||  |||  .|  .   ||. .  .       |.     .|            .|. | . .     ..|.||. | |     . 
riivmlsresencrikcdrywpeqiggeqfsiygngnevf......gtysvelveviqdp...ereiitrnirltfegetrditqyqyegwpdhnipdht

ANFLEFLLQVRGRQY--------TSPIVVHCSAGIGRTGVFiCTD
  | ..|  .  ||           ||.||||||.|||| | || 
qpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtf.cta
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 169-421 3.2e-23 76.8 In-house 40-274 (281) alignment 
Range on Protein: 169-421
Range on HMM: 40-274/281.0
ANRYSDIVPYDHTLVELDT-------GDYINASFVQGESDATRWIATQGPidsgeciGKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMG
 |||..|   | . |.|          ||| | ...       .| ||||        ||| .|||||| | . ..|||| |  |   .|| ||.|    
knrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgp.......kketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

KTERYGEVDVKLvcelEEKTwVHRefdvsptssyssSTKSSRKsRASRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRqyTSPIVVHCSAGIG
   .. .. |.     |. | | .            |  ..|    | .     ...| .||| |         .|. | ..| |  ..| |.|||||.|
cclqfdklsvsy....edst.vnk............slvttrl.nlsyegetrlithwlwkewpdwqvpessevmlkilrkirar..stppvihcsagvg

RTGVFICTDN----VISRFESEGIIDIFSEVNRsrQQRPSMVYTVKQYECIYDIIGEYLRNYHQ
|.| ... .     . |.|    | .| | .      | . | |..||  |. .. ..   |.|
rsgtlmaveialqsihshftlpdikqivshlrv..tgraasvqtlqqymliwkvlldfgvaykq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 171-404 7.2e-22 72.2 In-house 42-276 (302) alignment 
Range on Protein: 171-404
Range on HMM: 42-276/302.0
RYSDIVPYDHTLVELD--TGDYINASFVQgeSDATRWIATQGPIDSGECIG----------KETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPS
| |  . . .|.  |     |.|||  ..   |  .|| .|||.|  | .           |.|.  .| .| ||.|| .| | .  ||  .|| ||.  
rkslficepktmaklvdfkndfinanvlk..ldeikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysd

AMGKTERYGEVDVKLVcELEEKtwVHREFDVSPTSSYSSSTKSSRKSRasrqQSHMKVSQWQYKEWKDTGgAPRIA-NFLEFLLQvrGRQYTSPIVVHCS
 .|.. ..|.  || | .....  ...  |      |.   | ..| .    . .. |.  ..  | | | ||. | . |. |       |   ..||||
kvggelkfgrytvktv.svktd..leeftdkksfklytveiknekkkk....kvkktvdilafsawpdhG.apkeaytaldilkf..cesykknvlvhcs

AGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQ
||.|||| ..     |     . . |. | |   || |   | . .|
aGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 154-278 1.8e-21 71.3 In-house 21-144 (297) alignment 
Range on Protein: 154-278
Range on HMM: 21-144/297.0
RRLTRSTDRATRHAAANRYSDIVPYDHTLVELDTG----DYINASFVQ--GESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQED
|  . |. .       ||| ||. .| | | |  .    ||||| .|    |    ..| .|||.       ..|| |||..... ||  |||. . |||
rgesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGpl.......satvddfwtlvaeqdvrvivmvaklqed

FVQKCGEYWPSAMGKTERYGEVDVKLVCELE
  .||  ||||. ..  . |.| |. . .  
Grdkcapywpsvvqerlkagdvvveflssts
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 204-410 1.9e-20 67.9 In-house 5-197 (198) alignment 
Range on Protein: 204-410
Range on HMM: 5-197/198.0
RWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLvceleeKTWVHrEFDVSPTSSYSssTKssr
|.|||| |.       .||..|||.|. .     |||. . | .       |||..   | .|| . |        || .  . | . |.     |.   
ryiatqhpl.......retladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt......ktitt.kpdytitalil..tn...

ksRASRQQSHMKVSQWQYKEWKDTgGAPRIANFLEFLLQVRG--RQY----TSPIVVHCSAGIGRTGVFICTDN-VISRFESE-GIIDIFSEVNRSRQQR
   ..   |  ..|..|.  ||.   .| .| |. |..  |   ..|     .|..|||| | | ||||.. |  | |  ||   ..|.|   .| || |
..nttappstreishyqftswkek.ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqar

PSMVYTVKQYECIYD
  .. ....|. ||.
cgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 204-410 2e-20 67.8 In-house 6-198 (199) alignment 
Range on Protein: 204-410
Range on HMM: 6-198/199.0
RWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLvceleeKTWVHrEFDVSPTSSYSssTKssr
|.|||| |.       .||..|||.|. .     |||. . | .       |||..   | .|| . |        || .  . | . |.     |.   
ryiatqhpl.......retmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt......ktitt.kpdytitalil..tn...

ksRASRQQSHMKVSQWQYKEWKDTgGAPRIANFLEFLLQVRG--RQY----TSPIVVHCSAGIGRTGVFICTDN-VISRFESE-GIIDIFSEVNRSRQQR
   ..   |  ..|..|.  ||.   .| .| |. |..  |   ..|     .|..|||| | | ||||.. |  | |  ||   ..|.|   .| || |
..nttappstreishyqftswkek.ttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqar

PSMVYTVKQYECIYD
  .. ....|. ||.
cgiisslqhynfiyq
subfamily_egg_pd Subfamily egg 187-418 7.1e-19 62.6 In-house 67-272 (307) alignment 
Range on Protein: 187-418
Range on HMM: 67-272/307.0
TGDYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDfvQKCGEYWPSAMGKTERYGEVDVKLVCeLEEKTWVHRE
..|.| |  |.|.     .| .| |.       |.|| |||||. | .|  ||||   .|   ..|  ||| |  .. ..    ... . |. .      
lddfihanrvkGkpllnefilaqapl.......kntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrien.lkvdskadpl

FDVSPTSSYSSStkssrksrasrqQSHMKVSQWQYkEWKDTGGaprIANFLEFLLQVrgRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGII--DI
| |.      .             .  . .  ||. ... ..    .   |. | ..  |. . |.||..  |. ....... .  .  .    |    .
frvtklklvGgd............deerflehwqg.dvnnssd...vysplrvlrkl..rnlskpvvvqdilGvskaatlvaieiallsllrGpitkslv

FSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRN
   |   |..|.  | .| .|  .| ..  ..|.
lravvflrlrrrlsvesvllylfvyrlvlfffrd
0048076 (Phosphotyrosine protein) phosphatases II 314-415 1.1e-18 62.8 In-house 45-142 (145) alignment 
Range on Protein: 314-415
Range on HMM: 45-142/145.0
MKVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQ-YTSPIVVHCSAGIGRTGVFICTDNVISrfesEGiIDIFSEVNRSRQQRPSMVYTVKQYECIYDII
 .. |..|  | | |  . .. .|||| ...  .    |..||||||.||||.... . ...    .| ..... ... |.||| .|... |.. .|. .
rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefe

GEY
 |.
lel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 168-417 2.2e-18 60.7 In-house 50-345 (349) alignment 
Range on Protein: 168-417
Range on HMM: 50-345/349.0
AANRYSDIVPYDHTLVELDT--------------------GDYINASFVQGE--SDATRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQ
| |||.||.||.|. | |                       ||||| ...    |   ..|||| |. |       || ||...|.   |  .. | . .
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPs.......tvddfykvillngvklvlsLnddk

EDFVQKCGEYWpsamgKTERYGEVDVKLVCELEEKTW----VHREFDVSPTSSYSSSTKS--------SRKSRASRQQSHMKVSQWQYKEWKDTGGAPRI
|  ..||  ||     .   | .. |||    .  .     . | . |  |..     |           ..    ...  .. | |.|.| |..     
elslekcdiyw.....qelsysnitvklqnsslyianvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnP

ANFLEFL-------LQVRGRQ-----YTSPIVVHCSAGIGRTGVFICTDNVISRFE-----SE-------GIIDIFSEVNRSRQQRPSMVYTVKQYECIY
  .|. |        .   |.      .|...|||||| |||||..  | ..| .|     |            |.  ||  |.|| |||  ..|.  ||
isilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiy

DIIGEYLR
. . .|..
ealLkyfa
0048179 (Phosphotyrosine protein) phosphatases II 309-410 8.6e-18 59.9 In-house 48-139 (144) alignment 
Range on Protein: 309-410
Range on HMM: 48-139/144.0
RqqshmkVSQWQYKEWKDTGGAPRIANFLEFLLQVRGR-QYTSPIVVHCSAGIGRTGVFICTDNVIsrfeSEGiIDIFSEVNRSRQQRPSMVYTVKQYEC
       . |...  | | |  . .. .||||  ..   .   |..||||||.||||.... . ..     .| ..... ... |..|| .|..  |.. 
e......giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrf

IYD
...
Lle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 169-416 1.4e-16 55.1 In-house 46-276 (312) alignment 
Range on Protein: 169-416
Range on HMM: 46-276/312.0
ANRYSDIVPYDHTLVEL--DTGDYINASFVQGESDATRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTERY
 ||| .|  .|     |  |   || | ||.  .   |...||||..       .|.. ||.. .    ..|..|    ||  .|| .|    .|  .  
lnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgple.......ntcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

gevDVKLVceleekTWVHREFDVSPTSSYsSSTKSSRKS--RASRQQShmKVSQWQYKEWKDTGGAPRIANFLEFLLQVRgrQYTSPIVVHCSAGIGRTG
   | ..       |    | ..   |     |.   |   .|. |.|  |. ..|.  | | |        | .|  |.  .   |.. |||||.||||
...dhrvy......teycteieiggkskd.kithrvlkvvvkatgqes..klnhyqwaswpdhgmpdscdtalrllsavk..kdkkpviahcsagvgrtg

VFICTDNVISRFES---EGIIDIFSEVnrsRQQRPSMVYTVKQYECIYDIIGEYL
 ..  . .|. .     . . |.|  .   |..|   | .. ||     .. |.|
tlaliesmiaalrhprkqnvkdsfvll...rkdrarsvrvfpqyvyalrcvlefl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 222-401 1.4e-16 55.4 In-house 40-206 (255) alignment 
Range on Protein: 222-401
Range on HMM: 40-206/255.0
TVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVklVCELeektwvhrefdvsPTSSYSSSTKSSrKSRASRQQSHMKVSQWQY
||  |...||| .   .|||.  .|. |.|| .|.|    .  .. .|.|  ..               ...     |     |  ....   .|  ..|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnv..tttk.............ssadvvlrtlei.tstlgekkkthtvkhysy

KEWKDTGgAPRIANFLEFLLQVRGRQytSPIVVHCSAGIGRTGVFICTDNVIS------RFESEGIIDIFSEVNRSRQQRPSMVYT
| | .   ||. |. . ..|.|       ..|||||.||||.  |. .. |        .  . . .|  | ..  |..|.. ..|
kGWiekn.aPelareilnilkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraiht
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 315-414 5.2e-16 53.0 In-house 90-192 (440) alignment 
Range on Protein: 315-414
Range on HMM: 90-192/440.0
KVSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQ---YTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDI
 . |..|. | | |     .  |... .|   |     .|..|||||| ||||| |. |...   .    ||||| .|  |..|| || | .||  ... 
tlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhea

IGE
. |
vle
subfamily_eak_pd Subfamily eak 157-421 7.5e-16 52.4 In-house 41-310 (332) alignment 
Range on Protein: 157-421
Range on HMM: 41-310/332.0
TRSTDRATRHAAANR-YSDIVPYDHTLVELDT-----GDYINASFVQGESDATRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGQHQEDFVQ
 .|   ..|  | ||   .|||||. ||.| .       ||||| ..      ..| |  . .       . |  ||.|...    .||.| .. |  ..
llsisetarleavnrnvvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiase.......dkvfafwqmvleqkspaivqlledvelkle

KCGEYWPSAMGKTERYGEVDVKLVCELEEKTWVHREFDVSPTSSYSSSTKSSRKSRASRQQSHMKVSQWQYKEWKDTGgAPRIANFLEFLLQVRGRQY--
|   |.|    .  ..| .||.    ....    | . .|         .      .  .   ..     .|  |..| .. ...  . ||.   ..|  
ksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevG.vlllivmksallsstlkkyih

TSP---IVVHCSAGIGRTGVFICTDNVISRFESE--GIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRNYHQ
| |    .. .. |  |.|||.  | .|   ..       .   . . ...|   | . .|.  ||.|. .||.. ..
tppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn
subfamily_CG42327_pd Subfamily CG42327 347-415 1.1e-15 52.1 In-house 245-314 (319) alignment 
Range on Protein: 347-415
Range on HMM: 245-314/319.0
QYTSPIVVHCSAGIGRTGVFICTDNVISRFESE-GIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEY
.   |.||||| |.||||. | .|  | ..|     .||   |   |..| | | |..||| || .. ||
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 352-416 1.3e-14 48.3 In-house 1-65 (69) alignment 
Range on Protein: 352-416
Range on HMM: 1-65/69.0
IVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYL
.|||||.| |||| ||.    ..|  || ..||| .|.  |. || ||    .|  |.| . | |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 353-416 2.9e-14 47.1 In-house 1-64 (69) alignment 
Range on Protein: 353-416
Range on HMM: 1-64/69.0
VVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYL
|||||.| |||| ||     ..|  || ..||| .|.  |. || ||    .|  |.| . | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 350-412 5.3e-14 46.8 In-house 229-291 (297) alignment 
Range on Protein: 350-412
Range on HMM: 229-291/297.0
SPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDII
 ...||||||.||.|| . .| ....   . | |. . ..  |.||. .| |..|.| .||..
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_hpo-7_pd Subfamily hpo-7 221-401 1.9e-13 44.9 In-house 45-212 (263) alignment 
Range on Protein: 221-401
Range on HMM: 45-212/263.0
ETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVklVCELEEKtwvhrefDVSPTSSYSSSTKSSrKSRA-----Srqqshmk
.|.  |...|||     .|||.  .|. |.|| .|.|    .  .. .|.|  ..    .       ||   .    || .  | .              
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnv..cttkvqs.......dvllktlellstlge.Kkkthtvkhy.......

vsqwQYKEWKDTGGAPRIANFLEFLLQVRGRqytSPIVVHCSAGIGRTGVFICTDNVIS------RFESEGIIDIFSEVNRSRQQRPSMVYT
    .|| | .. .     . |. |  .|.     ..|||||.||||.  |  .. |        .  | . .|  | ..  |..|.. ..|
....sykgWiekndpelareilnilkvarns...kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht
subfamily_CG42327_pd Subfamily CG42327 176-274 3.2e-13 44.0 In-house 38-138 (319) alignment 
Range on Protein: 176-274
Range on HMM: 38-138/319.0
VPYDHTLV------ELDTGDYINASFVQGESDAT-RWIATQGPidsgeciGKETVSDFWRMIVQYDVACIVMLGQHQEDFVQKCGEYWPSAMG--KTERY
||  .| |      . |   |..||.|.|  ||   .||.| .       .... |||||.. .     || | . .|  ...| ||.|.  .   |. |
vPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvs.......ledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

GEVDVKLV
|.. | | 
Gdilvtlk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 166-244 2e-10 34.7 In-house 47-117 (303) alignment 
Range on Protein: 166-244
Range on HMM: 47-117/303.0
HAAANRYSDIVPYDHTLVELDTGDYINASFVQGESDaTRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGQH
    ||. |..  ||. |.|    || ||... .|.  . | || |.         | .|||.||..  | |...|   
nmdknrfvdvicldhskvklsdssyihasyleldss.kkailtqlpls.......htaadfwqmiieqkvkcvlllltd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 188-286 7.1e-10 33.5 In-house 46-147 (290) alignment 
Range on Protein: 188-286
Range on HMM: 46-147/290.0
GDYINASFVQGeSDATRWIATQGPIDSGECIGKETVSDFWRMIVQYDVACIVMLGQHQEDFVQ----KCGEYWPSAMGKTERYGEVDVKLVCELEEKTWV
 ||| |..|.  ..  | |.|| |        . |. .|| |. |  |  .|||.. .|   .     | .| | ..|.  ... . ||     .|.   
ddyiHAnrvtc.pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

HRE
.||
tRe
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 322-418 9.7e-10 32.3 In-house 189-287 (302) alignment 
Range on Protein: 322-418
Range on HMM: 189-287/302.0
KEWKDTGGAPRIANFLEFLLQV--RGRQYTSPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGEYLRN
. ||.. .  ..|.  .   .|  .  . ....|.    |.|| |.|.    .... ...    |   |.  |.|||..| ..|||  .| ..  |...
tnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
0038934 (Phosphotyrosine protein) phosphatases II 324-416 2.6e-09 32.5 In-house 87-177 (194) alignment 
Range on Protein: 324-416
Range on HMM: 87-177/194.0
WKDTGGAPRIA---NFLEFLLQVRGRQYTSPIVVHCSAGIGRTGVFICTDNVIS-RFESEGIIDIFsevnrsRQQRPSMVYTVKQYECIYDIIGEYL
..| | .| ..   .||... ..  ..    ..||| ||.||||....   . . ..  |  |..|      |. ||.........| ..   .|. 
fpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialf......rekRpgaipnqdyleallkrykelr
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 150-406 3.3e-08 27.4 In-house 18-292 (332) alignment 
Range on Protein: 150-406
Range on HMM: 18-292/332.0
RTEARRLTRSTDRATRHAAANRYSDIVPYDHTLVELDT----GDYINASFVQGESDATRWIATQGPIDSgecigkETVSDFWRMIVQYDVACIVMLGQHQ
.| |     . |.       ||   .  .||. |||       |. |||.|.| |  . .| .| |..        |   ||||. .   . |...|. .
htsamtypntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfnd......hteyvfwrmvserkpsmilvfgdid

EDFVQKCgEYWPSAMGKTER-YGEVDVKLVCELEEKTWVHREFDVSPTSSYSSSTKSSRKS--------------RASRQQSHMKVSQwQYKEWKDTGGA
|   .|.  |  |  |  .    |.  | . | | |. . |.|    .|     . | . |               . ..| |  |   .. || |.   
ekqkrka.pydisdrgfeksflhefgaksleecelkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlm.hfyewadaskl

PRIANFLEF---LLQVRGRQYT----SPIVVHCSAGIGRTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYE
|     .     |  .|  . |     ||.. |..|. .  ..   | ..||   |  . .   ..  . ||   . ||  | 
peymldmrasiklqyirsskktgvcigpimlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpys
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 189-260 1.3e-07 25.5 In-house 123-182 (244) alignment 
Range on Protein: 189-260
Range on HMM: 123-182/244.0
DYINASFVQGESDATRWIATQGPIdsgecigKETVSDFWRMIVQYDVACIVMLGQHQEDfvqkcGEYWPSAM
 |||||||     .. .| || |.        .|  |||.|...  |  .|.||  .|.      |||| . 
tyinasfvgclgrtaeyiltqhpl.......adtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 198-259 1.6e-07 25.0 In-house 231-282 (440) alignment 
Range on Protein: 198-259
Range on HMM: 231-282/440.0
GESDATRWIATQGPIDSgecigkeTVSDFWRMIVQYDVACIVMLGQHQEdfvQKCGEYWPSA
| |    .|||| |.||       || ||||.. .| .. |.|| | ..   . |  |||  
gyskknafiatqmplds.......tvldfwrlvhdyristiimlnqlnd...ktcsiywpvn
subfamily_PTPDC1_pd Subfamily PTPDC1 347-410 2.1e-07 25.5 In-house 112-170 (182) alignment 
Range on Protein: 347-410
Range on HMM: 112-170/182.0
QYTSPIVVHCSAGIGRTGVFICTDNVIS-RFESEgiidifSEVNRSRQQRPSMVYTVKQYECIYD
     . ||| || ||||| |..  | . |...|        ..  |..||. ..| .| |.. .
lqegkvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelvke
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 136-210 2.4e-07 24.8 In-house 20-95 (95) alignment 
Range on Protein: 136-210
Range on HMM: 20-95/95.0
NRRRLLQDEFLVLSRTEARRLTRSTDRAtrHAAANRYSDIVPYDHTLVELDT---GDYINASFVQGESDATRWIATQG
|  . ...||  .| |     |  .  |      ||. .|.||| | | | |    ||||| ||.| .    .||.||
nsdqefdnefksismtsgapytvgssea..nipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 166-271 5.3e-07 23.4 In-house 51-153 (302) alignment 
Range on Protein: 166-271
Range on HMM: 51-153/302.0
HAAANRYSDIVPYDHTLVELD--TGDYINASFVQGESDATRWIATQGPIDSGEcigkETVSDFWRMIVQYDVACIVMLGQHQEdFVQKCGEYWPSAMGKT
. . |.  |.  .|..|| |.    .|.||| |.  .     | .| |. . |    . | .||||. |  .. .|.| ...|   .   |..|  .|. 
nlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdse....dsveeFWrmvfqekivsvvilvgeee.lkktlselfpkksgdy

ERYGEVDV
. ||.. |
keygkmfv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 183-260 9.3e-07 23.2 In-house 8-73 (130) alignment 
Range on Protein: 183-260
Range on HMM: 8-73/130.0
VELDTGDYINASFVQGESDATRWIATQGPIDsgecigkETVSDFWRMIVQYDVACIVMLGQHQEDfvqkcGEYWPSAM
  |.  .|||||||     .. .. || |.        .|  |||.|...  |  .|.||  .|.      |||| . 
srlqgntyinasfvGllgrtaeylltqhpla.......dtsmdfwkmmleryvnvlvvlgsveee.....deywpdse
Y_phosphatase3 Tyrosine phosphatase family 292-368 2e-06 22.9 Pfam-A 76-143 (164) alignment 
Range on Protein: 292-368
Range on HMM: 76-143/164.0
TSSYsssTKSSRKSRASRQQSHMKVSQWQYKEWKDTGgAPRIANFLEFLLQvrgRQytSPIVVHCSAGIGRTGVFIC
....   .... ..|....... .  .  |.|  ..  .......|| |..   ..  .|...||.||  ||||.. 
eeae...speelaerlkeaeeaeeamaeayreilede.kkayrkvlealae...ee..gpvlfHCtaGKDRTGvvaa
OAD_gamma Oxaloacetate decarboxylase, gamma chain 25-79 3e-06 14.1 Pfam-A 25-76 (79) alignment 
Range on Protein: 25-79
Range on HMM: 25-76/79.0
ILYVYHKTssrlrraSRGRTPKQVQQLPKVEEPAPPPVE----VTTKEIAVIAAAAAAD
|... .|.        .  .|.. .. ...|......||    . ....|.|.|| ||.
iisllskv.......ikkaapeekaekkaeeaakaesveekkeddpelvAaItaAvaah
DSPc Dual specificity phosphatase, catalytic domain 307-368 8e-06 20.8 Pfam-A 33-92 (133) alignment 
Range on Protein: 307-368
Range on HMM: 33-92/133.0
ASRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVrgRQYTSPIVVHCSAGIGRTGVFIC
 ....|. .  . . .. ..|  .. . .  ||. ..  .|    ..||| ||| |.. .|.
naikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 307-368 8e-06 20.8 In-house 33-92 (133) alignment 
Range on Protein: 307-368
Range on HMM: 33-92/133.0
ASRQQSHMKVSQWQYKEWKDTGGAPRIANFLEFLLQVrgRQYTSPIVVHCSAGIGRTGVFIC
 ....|. .  . . .. ..|  .. . .  ||. ..  .|    ..||| ||| |.. .|.
naikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatlii