Gene Y80D3A.8 in Caenorhabditis elegans

Synonym: CELE_Y80D3A.8, CELE_Y80D3A.8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf19
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP231_AA protein Get Run
CeleP231_AA_962-1251 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 960-1259 2.1e-179 589.8 In-house 1-300 (301) alignment 
Range on Protein: 960-1259
Range on HMM: 1-300/301.0
KQIKGIEKWTKSMDFKDNHKTAKFYNTTIENVNVTTIDKDHITESYAYLPKNKHRYPTLPCKPSTAVKVIVNGQRVPIHANWVPTPGHPHRFIVTQGPLK
|..| ||||..|.||||..||||||||||||||||||||||||||||||||.||||||.||||||||.|||.|.||||||||.||.|||||||.||||||
kkvkkiekwiiskdfkdddktakfynttienvnvttidkdhitesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlk

NTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKITDGKSILNKKIYQRTLEVVDSTGKLATRTVMHYQYAGWTARGVPKSH
||..|||.||.|||||.||||||..|.|. ||..|.| .||| ..||||.|||.. ..||||||..|||||.|||||.|||||.||||. ||.|||||||
ntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPksh

AEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWMTLGTMYRLIKEYGFDMKIYDQQMAIFS
||.|||||..|||||||||.|..|||||.||||||.|||.|||||||||||||||.|||||||.|.|.|||||||||.||||||||||||||..|.|.|.
aelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlikeygfdmkiyeeqlamfd
0036941 (Phosphotyrosine protein) phosphatases II 1010-1257 1.4e-64 213.6 In-house 40-293 (297) alignment 
Range on Protein: 1010-1257
Range on HMM: 40-293/297.0
KNKHRYPTLPCKPSTAVKViVNGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFN
..|.||.  .. ..| ||.  ..    |.|..|........||.|||||.|| .||| |. ...|..|||| . .|.  .||. | |. . |... |.| 
leknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdft

IKITDGKSILNKKIYQRTLEVVDSTGKlATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKK------SEKPIVVQCPNGIGRSMAFIGTECLARQVE--
.. .. ...|.. . .|||||.|  ..  .|||.|..| ||   ||| |.|...|..|...|      |..|..| | .|.|||..||. ... .|.|  
vtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledk

-ADPTIELTEALKHMREHRWNGIQKNFQLYWMtLGTMYRLIKEYGFDMKIYDQQMAI
   ... . ||.|..||.|.. .|   |....   ... |.| . ... .... ...
lkeggvdileavkklReqRpgavqtleqyrfl.yeallellkkkltkepllklvlll
0040438 (Phosphotyrosine protein) phosphatases II 963-1244 1.6e-63 210.3 In-house 3-275 (317) alignment 
Range on Protein: 963-1244
Range on HMM: 3-275/317.0
KGIEKWTKSMDFKDNHKTAKFYNTTIENvnvttiDKDHITESYAYLPKNKHRYPTLPCKPSTAVKVIVNGQRVP---IHANWVPTPGHPHRFIVTQGPLK
...... . ....|...  ..... ...      ..|...... .  |.|.|||  .. ... ||. . | . .   |.|..|..| ....||.|||||.
ldlllalldllksdftalleefedllsl......kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlp

NTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPhiSEPFKIGRFNIKITDGKSilNKKIYQRTLEVVDStGKLATRTVMHYQYAGWTARGVPKSH
|| .||| |. ...|..|||| . .|.  .||. | |    |. ..|.| ..... .   .. |  |||||.|. |.  .|||.|..| ||.  |||.|.
ntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppsp

AEMFDLMEMLKKS----EKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWMtlgtmYRLIKEY
 ...|..|.....    ..|..| | .|.||...||. ... .|.|   .. ..||.|..||.|....|   |....     |... ||
dllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrfl.....ydalley
0050432 (Phosphotyrosine protein) phosphatases II 946-1232 8.2e-61 201.3 In-house 10-291 (308) alignment 
Range on Protein: 946-1232
Range on HMM: 10-291/308.0
EKRLYEEKEKEQRKKQIKGIEKWTKSMDFKDNHKTAKFYNTTIENVNvttidKDHITESYAYLPKNKHRYPTLPCKPSTAVKVivNGQRVPIHANWVPTP
|. |. ...  . ....  .. . . .. .|...  . ...  .. .        .. ..    |.|.||.  ..  .. ||.  ..    |.|..|...
elllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp.....lleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgy

--GHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHIS-EPFKIGRFNIKITDGKSilNKKIYQRTLEVVDSTGKlATRTV
  ..|..||.|||||.|| .||| |. ...|..|||| . .|| ..||. | |. .  .. ..|.| ..... ..  .. . .||||.... ..  .|||
ssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdg.esrtv

MHYQYAGWTARGVPKSHAEMFDLMEMLKKS--EKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWM
.|..| .|   ||| | ....|..|...||  ..|||| | .|.||...||  ..| .|.|.. .. . ||.|..||.|.. .|   |....
thfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl
0045450 (Phosphotyrosine protein) phosphatases II 965-1231 6e-60 198.9 In-house 14-295 (307) alignment 
Range on Protein: 965-1231
Range on HMM: 14-295/307.0
IEKWTKSMDFKDNHKTAKFYNttiENVNVTTIDKDHITESYAYLPKNKHRYPTLPCKPSTAVKVIVNGQRVP----IHANWV--------PTPGHPHRFI
.... . .  ..... .| ..   . ..||... ....... .  |.|.||.  .. ..| ||. . .....    |.|..|        ... ....||
llllvllllldfltgllkefe...kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfI

VTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHiSEPFKIGRFNIKITDGKSilNKKIYQRTLEVVDSTGKLATRTVMHYQYAGWTA
.|||||..| .||| || ...|..|||| . .|.  .||. | |   .|.. .|.| .. .. .    ...  ||||| |. |.  .|||.|..| ||  
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpd

RGVPKSHAEMFDLMEMLKK------SEKPIVVQCPNGIGRSMAFIGTECLARQVEADPT---IELTEALKHMREHRWNGIQKNFQLYW
 |||.| .|..|..|...|      ...|..| |  |.||...||.   . ||.|...|   . | ||.|..||.|....|   |...
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrf
0039614 (Phosphotyrosine protein) phosphatases II 960-1232 4.2e-56 185.9 In-house 14-281 (297) alignment 
Range on Protein: 960-1232
Range on HMM: 14-281/297.0
KQIKGIEKWTKSMDFKDNHKTAKFYNTTIENVNvttidkDhITESYAYLPKNKHRYPTLPCKPSTAVKVIVNGQ----RVPIHANWVPTPGH-PHRFIVT
.... .. . . .. .....  . . . ....       | ..... .  |.|.||.  .. ... ||. ...        |.|..|... . ...||.|
iplsvldlllllekansktllllefeellslkp......d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIvKCDYYIPPHISepfKIGRFNIKITDGKSilNKKIYQRTLEVVDsTGKLatRTVMHYQYAGWTARG
||||..| .||| |. ...|..|||| . .|.   ||. | |.  .   . |.| .. .. .   .. ...|||||.. .|.   |||.|.|| ||   |
qgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn.nges..rtvthfqytgwpdhg

VPKSHAEMFDLMEMLKK------SEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWM
|| |.. .....|....      ...|..| | .|.||. .||.   . .|.|   .. . ||.|..||.|....|   |... 
vppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfl
0043336 (Phosphotyrosine protein) phosphatases II 978-1231 5e-56 185.6 In-house 14-268 (278) alignment 
Range on Protein: 978-1231
Range on HMM: 14-268/278.0
HKTAKFYNTTIENVNVTTIDKDHITESYAYLPKNKHRYPTLPCKPSTAVKVIVNGQRVP---IHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDV
 . . .. .  |  .......|... .. .  |.|.||.  .. ... ||. . | . .   |.|..|... .|..||.|||||..| .||| |. ...|
lllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

EHIVMLGQNMENLIVKCDYYIPphiSEPFKIGRFNIKITDGKSilNKKIYQRTLEVVDsTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKK---
..|||| . .|.  |||..| |   ......|.| .. .. ..  .. . .|||||.. .|.  .|||.||.| ||   ||| | . ..|.......   
ttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

-SEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYW
 |..|..| | .|.||...||. . | .|.|   .. | ||.|..||.|.. .|   |...
dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf
0047943 (Phosphotyrosine protein) phosphatases II 1002-1232 2.1e-55 183.5 In-house 31-264 (273) alignment 
Range on Protein: 1002-1232
Range on HMM: 31-264/273.0
TESYAYLPKNKHRYPTLPCKPSTAVKViVNGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISE
. ..    |.|.||. ...  .. ||.  .|    |.|..|... ....||.|||||.|| .||| |. ...|..|||| . .|.  .||..| |.   |
svallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwplegge

-PFKIGRFNIKITDGKSilNKKIYQRTLEVVDSTGKLaTRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKK------SEKPIVVQCPNGIGRSMAFIGTE
 . . |.| ..... ..  .. ...||||....  .  .|||.|..| ||   ||| | .......|...|      |..|.|| | .|.||...||  .
lsltygkftvtllseet..kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfiald

CLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWM
.| .|.|.  .. . ||.|..|..|....|   |....
llldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
Y_phosphatase Protein-tyrosine phosphatase 1010-1232 2.4e-55 182.9 Pfam-A 2-229 (235) alignment 
Range on Protein: 1010-1232
Range on HMM: 2-229/235.0
KNKHRYPTLPCKPSTAVKV-IVNGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRF
|.|.||.. ..  .| ||.   .|.   |.||.| .  ....||.||||||.|  ||| |..|..|. |||| ...|.  .||..| | . .|. . |..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

NIKITDGKSILNKKIYQRTLEVVDSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSE----KPIVVQCPNGIGRSMAFIGTECLARQVEADP
.....  ..  .|..  |.||. ..... ..|.|....| .|. .|||.|  ...||.....||.    .|.||.| .|.||.. |.  ..| .|.||. 
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaee

TIELTEALKHMREHRWNGIQKNFQLYWM
.... ...|..|..| . .|.  |....
evdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 1010-1232 2.4e-55 182.9 In-house 2-229 (235) alignment 
Range on Protein: 1010-1232
Range on HMM: 2-229/235.0
KNKHRYPTLPCKPSTAVKV-IVNGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRF
|.|.||.. ..  .| ||.   .|.   |.||.| .  ....||.||||||.|  ||| |..|..|. |||| ...|.  .||..| | . .|. . |..
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

NIKITDGKSILNKKIYQRTLEVVDSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSE----KPIVVQCPNGIGRSMAFIGTECLARQVEADP
.....  ..  .|..  |.||. ..... ..|.|....| .|. .|||.|  ...||.....||.    .|.||.| .|.||.. |.  ..| .|.||. 
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaee

TIELTEALKHMREHRWNGIQKNFQLYWM
.... ...|..|..| . .|.  |....
evdvlqivkelRkqRpgmvqsleqYifl
0046845 (Phosphotyrosine protein) phosphatases II 1000-1232 4.2e-55 182.5 In-house 19-266 (284) alignment 
Range on Protein: 1000-1232
Range on HMM: 19-266/284.0
HITESYAYLPKNKHRYPTLPCKPSTAVKVIVNGQR----VPIHANWVPTP-----GHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVK
... ....  ..|.||. ...  .. ||. . ...      |.|..|...      ....||.|||||.|| .||| |. ...|..|||| . .||  .|
slsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrek

CDYYIPPHiSEPFKIGRFNIKITDGKSilNKKIYQRTLEVVDSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKS------EKPIVVQCPNGI
|..| |.  .|....|.| ..... .   .. . .||||...   .  .|||.|..| .|  .||| | . ...........      ..|||| | .|.
caqYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGv

GRSMAFIGTECLARQVEADP---TIELTEALKHMREHRWNGIQKNFQLYWM
||...||  ..| .|.|..    .. . ||.|..||.|.. .|   |... 
gRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv
0051299 (Phosphotyrosine protein) phosphatases II 967-1232 8e-55 181.7 In-house 12-278 (288) alignment 
Range on Protein: 967-1232
Range on HMM: 12-278/288.0
KWTKSMDFKDNHKTAKFYNTTIENVNVttidkDHITESYAYLPKNKHRYPTLPCKPSTAVKVIVNGQ---RVPIHANWVPTPGHPHRFIVTQGPLKNTRY
|. . .  ..... .. ... ...         ... ..    ..|.||. ...  .. ||. | ..      |.|...... ....||.|||||.|| .
klvlkllangltglleefeellsllpd.....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntve

DFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPhiSEPFKIGRFNIKITDGKSilNKKIYQRTLEVVDST---GKLATRTVMHYQYAGWTARGVPKSHA
||| |. ...|..|||| . .|.  .||..| |.  ... ..|.. ..... ..  .... .|||||.. .   |.  .|||.|..| .|   ||| |  
dFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

EMFDLMEMLKKS----EKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWM
...|......|.    ..|.|| | .|.||...||  ..| .|.|.  .... ||.|..||.|.. .|   |... 
llldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv
0040439 (Phosphotyrosine protein) phosphatases II 1001-1231 2e-53 176.9 In-house 3-237 (249) alignment 
Range on Protein: 1001-1231
Range on HMM: 3-237/249.0
ITESYAYLPKNKHRYPTLPCKPSTAVKVIVNGQRVP---IHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPP
..... .  |.|.|||  .. ... ||. . . . .   |.|...... ...|||.|||||..| .||| || ......|||| . .|.  .||. | |.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

hiSEPFKIGRFNIKITDGKSilNKKIYQRTLEVVDStGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKK------SEKPIVVQCPNGIGRSMAFI
  ......|.| .. .. ..  ......||||.... ..  .|||.|.|| .|   |||.| ....|..|...|      ...|..| | .|.||. .||
..ggsleygdftvtllsvev..kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

GTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYW
.   . .|.|   .. | ||.|..|..|....|   |...
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrf
DSPc_SM00195 998-1232 1.1e-52 174.3 In-house 16-254 (263) alignment 
Range on Protein: 998-1232
Range on HMM: 16-254/263.0
KdHITESYAYLPKNKHRYPTLPCKPSTAVKVIVNG---QRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYY
| ..||.     |.|.||   ..  .| ||.  .    .   |.||.. .. .....|.|||||..|  ||| | .. .|. |||| ...||   ||| |
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

IPPHISEPFKIGRFNIKITDGKSILnKKIYQRTLEVVDSTGkLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEK----PIVVQCPNGIGRSMAF
 |  . .. ..|....|... ..   ..| .||||.   .    ||.| .||| .|. .|||.|. ....|....|||..    ||||.| .|.||. .|
wpeesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

IGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWM
. .... ...|.. .... | .|..|..| . .|.  |. ..
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi
PTPc_SM00194 998-1232 1.1e-52 174.3 In-house 16-254 (263) alignment 
Range on Protein: 998-1232
Range on HMM: 16-254/263.0
KdHITESYAYLPKNKHRYPTLPCKPSTAVKVIVNG---QRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYY
| ..||.     |.|.||   ..  .| ||.  .    .   |.||.. .. .....|.|||||..|  ||| | .. .|. |||| ...||   ||| |
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

IPPHISEPFKIGRFNIKITDGKSILnKKIYQRTLEVVDSTGkLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEK----PIVVQCPNGIGRSMAF
 |  . .. ..|....|... ..   ..| .||||.   .    ||.| .||| .|. .|||.|. ....|....|||..    ||||.| .|.||. .|
wpeesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

IGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWM
. .... ...|.. .... | .|..|..| . .|.  |. ..
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi
0042113 (Phosphotyrosine protein) phosphatases II 1006-1232 1.3e-52 174.0 In-house 6-235 (245) alignment 
Range on Protein: 1006-1232
Range on HMM: 6-235/245.0
AYLPKNKHRYPTLPCKPSTAVKVIVNGQRV---PIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPhiSEP
 .  |.|.||.  .. ..| ||. . | .    .|.|..|... ....||.|||||..|  ||| || ......|||| . .|.  |||. | |.  .|.
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges

FKIGRFNIKITDGKSilNKKIYQRTLEVVDsTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKK-----SEKPIVVQCPNGIGRSMAFIGTECLA
...|.| .. .. ..  ......|||||.. .|.  .|.|.||.| .|   ||| ... ..|..|...|     |..|..| |  |.||...||.   ..
ltygdftvtllseeh..lddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

RQVEADPTIELTEALKHMREHRWNGIQKNFQLYWM
.|.|.  .. | ||.|..|..|.. .|   |....
eqlekelgvsleeavkelrsqRpgavqtpsqyrfl
0045098 (Phosphotyrosine protein) phosphatases II 999-1232 9.2e-51 168.2 In-house 23-264 (278) alignment 
Range on Protein: 999-1232
Range on HMM: 23-264/278.0
DHITESYAYLPKNKHRYPTLPCKPSTAVKvivngQrvPIHANWVPTPghPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPh
. ||..    ...|.||.  .. ... ||         |.|......  |..||.|||||..|  ||| || ......|||| . .|.  .||. | |. 
seitpalylgnldknRykdilpydhsrVk.....d..YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.

iSEPFKIGRFNIKITDGKSIlnKKIYQRTLEVVDS---TGKLATRTVMHYQYAGWTARGVPKSH--AEMFDLMEMLKK-----------------SEKPI
 .... .|.| ..... . .  .... |||.|..       | .|.| |..| .|   ||| ..  . ...|.|....                 |..|.
.ggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

VVQCPNGIGRSMAFIGTECLARQVeaDPTIELTEALKHMREHRWN-GIQKNFQLYWM
.| |  |.||. ....  .. ...  .... | ||.|..|..|..  .|   |....
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrfl
0037934 (Phosphotyrosine protein) phosphatases II 1005-1231 3e-44 146.8 In-house 6-233 (243) alignment 
Range on Protein: 1005-1231
Range on HMM: 6-233/243.0
YAYLPKNKHRYPTLPCKPSTAVKVivNGqRVPIHANWVPTPGhphRFIVTQGPLKNTRYD----FWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPphis
  .  ..|.||.. .. . . ||.  .|    |.||... ..   |.|.|||||..|  |    || || ......|||| . .|.  .||. | |    
llpenlsknrysdilpydhsrvkl..eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....

EPFKIGRFNIKITDGKSilNKKIYQRTLEVVDSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLK------------KSEKPIVVQCPNGIGRSM
... .|.| ..... ..   ... .|||...    .  ||.|.||.| .|   ||| |.. . |......            .|..|..| |  |.||. 
gevtygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

AFIGTECLARQVeadpTIELTEALKHMREHRWN-GIQKNFQLYW
..|    . ...    .. | ||.|..||.|.. ..|   |...
tliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrf
subfamily_PTPRB_pd Subfamily PTPRB 957-1230 4e-38 126.1 In-house 4-275 (293) alignment 
Range on Protein: 957-1230
Range on HMM: 4-275/293.0
QRKKQIKGIEKWTKSMDFKDNHKTAKFYNTtIENVNVttidKDHITESYAYLPKNKHRYPTLPCKPSTAVKV-IVNGQR--VPIHANWVPTPGHPHRFIV
... ... .|.. |.|  ..... .. |.. ...|.     .  .. . .   ..| ||  .     . ||.  .....    | ||..|    |. ||.
skpiklekfeehvkkmkadsdlrfseeyee.lkavgk....dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefia

TQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHiSEPFKIGRFNIKITDGKSIlnKKIYQRTLEVVDstgKLATRTVMHYQYAGWTAR
||||| .|. ||| |. .  .. |||| | .|.  |||. | | . .||   |  .....  ..   ..   |.|..     . ..|.|..|..  |.  
tqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad.eepvlyGdikvtlvaeeel..edwvirelkiek...ekeerkvrqyhftsWpdh

GVPKSHAEMFDLMEMLKKS------EKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLY
|||.. . . |........      ..|||| |  |.||. .||  . | ...| . .....  . ..||.| . .| . |  
gvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 967-1231 1.2e-37 124.6 In-house 10-270 (288) alignment 
Range on Protein: 967-1231
Range on HMM: 10-270/288.0
KWTKSMDFKDNHKTAKFYNTTienVNVTTIDKDHITESYAYlpKNKHRYPT-LPCKpSTAVKVIV---NGQRVPIHANWVPTPGHPHRFIVTQGPLKNTR
.... .. ...    . ||.     ..   .......      ..| ||.  ||    ..||.     . .   | |...   .. ...| ||||| .| 
akvakksarnrtgfseeynsL...aalektksvtagrlavn..akknRyrnilpyD.ekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtv

YDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPpHISEPFKIGRFNIKITDGKSIlnKKIYQRTLEVVdstGKLATRTVMHYQYAGWTARGVPKSHAEM
 ||| .  ..... |||| . .|.   ||. | | .  .| . | ....... |    ... .|.|...    |   ... .||| .|.  |||.|.|..
ndfWelvyenktstivmltelveggktkCeeYWP.dadkpknyGsvtvtlveskel..edfvlrkllle...kkkteleitqyqylaWpdhgvPeskapl

FDLMEMLKK---SE-KPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYW
..|....|    .. .||.|.| .|.||.  ||  ..|  .||.. .|.........|..| . .|.  |  .
lellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYef
subfamily_PTPRD_pd Subfamily PTPRD 964-1228 1.3e-37 124.7 In-house 9-269 (564) alignment 
Range on Protein: 964-1228
Range on HMM: 9-269/564.0
GIEKWTKSMDFKDNHKTAKFYNTTIENVNVTTIDKDHITesyaylPKNKHRYPTLPCKPSTAVKV-IVNGQRV--PIHANWVPTPGHPHRFIVTQGPLKN
 ......... ... |  . |..  |. ..|.   .. .       |.| ||       .. |.   |.|.     | |... .  ... .| |||||..
elkehvaklkansdlkfeeeykkieegqqftweaankpa......NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHiSePFKIGRFNIKITDGKSIlnKKIYQRTLEVvDSTGKLATRTVMHYQYAGWTARGVPKSHA
|  ||| |....... |||| .  |.  |||. | | . . . ..|.. ..... . .  ...  ||...   . .  .|.| ....  |  .|||.| .
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeel..adyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesat

EMFDLMEMLKKS----EKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQ
.. ||..  ...    ..||||.| .|.||. .||  ... ...... |... . .|..|..|   .|.. |
slLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQ
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 996-1232 6.1e-36 119.0 In-house 27-268 (281) alignment 
Range on Protein: 996-1232
Range on HMM: 27-268/281.0
IDKDHI-TESYAYLPKNKHRYPTLPCKPSTAVKVIVNGQR---VPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKC
|. |.  | |.|   ..|.||  .     | |||  | .      | ||.||.   ....|.||||. .. ..|| |. ...|. |||. ...|.  .||
igvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkC

DYYIPpHISEPFKIGRFNIKITdgKSILNKKIYQRTLEVVDSTGklATRTVMHYQYAGWTARGVPKSHAEMFDLMEML-----KKSEKPIVVQCPNGIGR
  | |   ..  |.| . .| |  ..  ...  .|....  ..|   ||.| . .|  |   |||.. .|...  . .     ||.. |.|. |  |.||
hrYWP.ddnselkygdvtvkst..aeeekatyierkfkleresg..etreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGr

SMAFIGTECLARQVEAD-PTIELTEALKHMREHRWNGIQKNFQLYWM
. ..|. . |...|||. ....... ....|..|   .|   |  ..
tGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1009-1232 2.5e-35 117.0 In-house 41-269 (307) alignment 
Range on Protein: 1009-1232
Range on HMM: 41-269/307.0
PKNKHRYPTLPCKPSTAVKVIVNGQRV-PIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGR
  .| ||  ..|.  . . | ..|     ||||.. .  .|..||..||||.||.|.|| |  | .|| ..|| . .|   .||. | |    .    | 
ntdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfge

F--NIKITD-GK---SILNKKIYQRTLEVVDSTGklaTRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTECLA-RQV
    | ... |    .  .. |   ||.|. . .   .||. |.|.  |  ||||.      .|.|  .  . |.|| |  |.||| . ..   .  . .
apntisvanlgakklapdedlinvttlkvdwaqk...srtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmi

EADPTIELTEALKHMREHRWNGIQKNFQLYWM
.     .. . .. .|..|   ||...|  ..
aGinckdmkklveelrsqrhyaiqteaqylyl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 961-1249 1.2e-34 114.3 In-house 10-287 (290) alignment 
Range on Protein: 961-1249
Range on HMM: 10-287/290.0
QIKGIEKWTKSMDFKDNHKTAKFYNTTIENV-NVTTIDKdHITESYAYLpkNKHRYPTLPCKPSTAVKVIVNGQRVPIHANWVPtpGHPHRFIVTQGPLK
| . .||.. ..  |. .. || | ...     |  ... .| .  . .  .| ||  ..|   | | .   ..   .|||.|   |    ||.|||.||
qteafekfasdvvkknvdelakeyleklkpylpvqyler.kifdkntef..kknrykdvvcndktrvilkdGydGdyvhanyvk..GlkamfiltqGalk

NTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKITDGKSIlNKKIYQRTLEVVDST-GKlaTRTVMHYQYAGWTARGVPKS
.|  |.| |. | .|  |||| . .|.   ||. | | .  | . .| . .  .  ..  ...| ..|| | |   ||     . |..   |  . |..|
dtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddk.daniikktlsvrdkdsGk..ehklkhlkikswpdksvals

HAEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQlYWMtLgtmYRLIKEYGFDMK
   .. .. .|.|   |.|| |  ||||. .|.  |  .. .     ..| .  . .|. | | .| . | | . |    ... ..| |.|
tlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiq.yla.l...veilldlGkdfk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 989-1257 1.5e-34 114.5 In-house 28-299 (319) alignment 
Range on Protein: 989-1257
Range on HMM: 28-299/319.0
ENVNVTTIDKDHITESYAYLPKNKHRYP-TLPCKPSTAVKVIVNGQR--VPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNME
|  .. . ..|.....     |.| ||.  |..  .  |   ..|.     | |... .  . ..|| ||.||.||  ||| |. ....  .||| .  |
efkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklve

NLIVKCDYYIPPhiSEPFKIGRFNIKITDGKSIlnKKIYQRTLEVVDSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSE-----KPIVVQC
.| ||.  | |    .. . ||. ... . .    ...  | |..   .... ||.|.|.||  |.  .||..   . ||.. ..||      .|||| |
klkvklkkywpe..enfeeyGrlivtleeeeel..edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhC

PNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQlYWMTLGTMYRLIKEYGFDMKIYDQQMAI
 .|.||  .||  .    .|. . .... .  ...|  |   .|.. | | .   ..   .. .  .... | .. .
saGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeq.Ykfiyealleaveagdteievqdlrdrl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 997-1228 2.5e-34 113.8 In-house 36-271 (305) alignment 
Range on Protein: 997-1228
Range on HMM: 36-271/305.0
DKDHITESYAYLPKNKHRYPTLpcKPSTAVKVIV---NGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDY
.. ..... |   ||... .||   .   ...     ....  | |..| .  . ...||.|||||||  ||| .. .. |..|||| . .|.   ||  
esidvgkkeankaknrlkeitl..ldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrq

YIPPHISEPFKIGRFNIKITDGKSIlnKKIYQRTLEVVDSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKK----S-EKPIVVQCPNGIGRSM
| |  ..|. ..|.|...... |..  .   .| |..    ..  .|||..||   |   |||.. . . .|.. ..|    . ..|..| | .|.||. 
YWpesktekkefgefsvelksekta..sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtG

AFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQ
.||  .    ..... .... | ||..|..| . .|.  |
vfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldq
subfamily_PTPN13_pd Subfamily PTPN13 992-1228 5.2e-34 112.8 In-house 22-257 (273) alignment 
Range on Protein: 992-1228
Range on HMM: 22-257/273.0
NVTTIDKDHITESYAYLPKNKHRyPTLPCKpSTAVKVIVNGQrvPIHANWVPTP--GHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIV
.. ..|. ..... .   ||..|   ||.   | ||.  .|    | |...  |   . ...|..|||| .|  ||| |. . ..| |.|. .. |.  |
elkpldtcevgkkkenkdknryr.nvlPyd.etrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkv

KCDYYIPPHISEPFKIG-RFNIKITdgKSILNKKIYQRTLEVVDSTGKlATRTVMHYQYAGWTARGVPKSHAEMFDLM---EMLKKSEKPIVVQCPNGIG
||. | | . ... |.  |....    |    .   .|.|.| ||  . ..| |.| ... |   |||.| ||.  ..     |.... |||| |  |||
kchrywPesknkklkvsnrlevell..kvqkldgfvvralavkdsesg.esrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiG

RSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQ
|| ..|  . .   .| |  ....| ....|| |   .| . |
rsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdq
subfamily_PTPN3_pd Subfamily PTPN3 1005-1230 5.2e-34 112.4 In-house 35-265 (280) alignment 
Range on Protein: 1005-1230
Range on HMM: 35-265/280.0
YAYLPKN--KHRYPTLPCKPSTAVKViVNGQRVPIHANWV----PTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPh
 | .|.|  | ||  .    .| ||. ....   | ||.|    |. |   |.|.|||||..|  ||| |. . ... |||| ...|.  |||  | |  
aarkpenlsknryrdilpydatrvkl.kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.

ISEPFKIGRFNIKITDGksILNKKIYQRTLEVVDSTgKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKS----EKPIVVQCPNGIGRSMAFIGTE
 .. .. |.|..|..      .|..  | | . |.. .   |.... ||  |.  |||...|......| ..|     |.|.|| |  ||||.  .|  |
tedeleygefsvkceke..detksyvlrelvlkdke.tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlille

CLARQVEADPTIELTEALKHMREHRWNGIQKNFQLY
     .||   .   . ...||. | . .| . |  
talalieaaepvypldivrtmrdqramlvqtasqyk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1010-1233 9.4e-34 111.5 In-house 49-280 (305) alignment 
Range on Protein: 1010-1233
Range on HMM: 49-280/305.0
KNKHRYPTLPCKPSTAVKVIVNGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFN
..| ||  . |     ||.        ||||.| ||  |.||| || ||..|  ||| |  |  || | || . .|    ||  |.. .  . ...   .
agknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekg

----IKITDGKSILN----KKIYQRTLEVVDSTGKLaTRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTECLARQVE
    .|.   ...      |   ..|  |.. .|.  .| | || .  |  |||| .   ...|.|  . |  |||| |  ||||. . .  | .  |. 
qkisvkfessvtlkfrkdakakvtetvlviegpgek.arkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqll

ADPTIELTEA-LKHMREHRWNGIQKNFQLYWMT
|   || |.  |...|| | | || . |  .. 
agqiiedtdkilqkireqrnnsiqtdaqylfvh
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 996-1229 2.4e-33 110.7 In-house 43-279 (298) alignment 
Range on Protein: 996-1229
Range on HMM: 43-279/298.0
IDKDHITESYAYLPKNKHRYPTLPCKPSTAVKVIV---NGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCD
|.... . . .   |.| ||. .    |. | .     . .   | | .. .  . . ||.||.||..|  ||| |.|..|.. |||| .  |   .|. 
ieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyh

YYIPPHISEPFkiGRFNIKITDGKSilNKKIYQRTLEVVDSTGKlATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKS-----EKPIVVQCPNGIGRS
 | | . .| .  |......   ..    .. .|.|.| ... .  .|.| . ..  |. .|||. .  ..||..  ..|     .||..||| .|.|||
kywPdegkety..geitvsllskee..fadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRs

MAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQL
 .||  . .  .|... .... ...| .|..| . .| . | 
GtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqY
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1008-1233 2.5e-33 110.0 In-house 54-282 (305) alignment 
Range on Protein: 1008-1233
Range on HMM: 54-282/305.0
LPKNKHRYPTLPCKPSTAVKVIVNGQRVPIHANWVPTPGHPH-RFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFK--
. . | ||  .||.  .|||.        ||||.|  |  |. |||..|||| .|  .|| |. |  ||.|||| . .|   .||  | |    |  .  
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

IGRFNIKITDGKSILNKKIYQRTLEVVDSTGKlATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTEC-LARQVEAD
 |    ...  | .      | ||  .  .|.  . .| | |.. |  ||||  .   ..|.  .. |. ||||.|  ||||. . .  |  | .  |  
sgivvenvsgskpmerdaeiqitllnltysgd.qkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenk

PTIELTEALKHMREHRWNGIQKNFQLYWMT
|   . | .| .|..|   ||.. |  .. 
pcppmpelvkalrdqrafsiqndvqylfih
0041856 (Phosphotyrosine protein) phosphatases II 1010-1234 3.3e-32 106.9 In-house 2-165 (182) alignment 
Range on Protein: 1010-1234
Range on HMM: 2-165/182.0
KNKHRYPTLPCKPSTAvkvivngQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGqnmenlivkCDYYIPphisepfkigrfn
..|.||.  .. . .            |.||..  . .. |||.|||||..| .||. || .... .||.|          ...| |             
ldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

ikitdgksilnkkiyqrtlevvdstgKLATRTVMHYQYAGWTARGVPKsHAEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTECLARQveadpTIELT
                          .| .|....|.| .|   |||    |..|..|. .....|..| |  |.||. ....   . ..      . |.
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

EALKHMREHRWNGIQKNFQLYWMTL
||.|..|..|.....   |...  |
eavklvrsrRpgmvitpnqyfflql
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 975-1228 5.6e-32 105.9 In-house 13-266 (287) alignment 
Range on Protein: 975-1228
Range on HMM: 13-266/287.0
KDNHKTAKFYNTTIENVNVTTIDKDHITESYAYLPKNKHRYPTLpcKPSTAVKVIVNGQR-VPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYD
|...|  . ...    ..  | ..|..| . |   |.| |.  .   .    .|...|..   | | .. .  . ..||....|. ||  .|| .. .  
kghakgnegfknqftvleqvtqredevthniasqnkdknRltqi..lvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrn

VEHIVMLGQNMENLIVKCDYYIPPHISepFKIGRFNIKITDGKsiLNKKIYQRTLEVVDSTGKLATRTVMHYQYAGWTARG-VPKSHAEMFDLMEMLKKS
|. |||| |..||   .|  | | . |    .| .||.... .   |..  .|.|||  .. . ....|. ||.. |  .| |..  . .. . || |. 
vtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

----EKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQ
    . .||| | ...|||  |.  .   .... . .|.. . ||..|  . . .|   |
rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveq
subfamily_PTPN12_pd Subfamily PTPN12 1037-1229 9.5e-32 105.0 In-house 71-268 (290) alignment 
Range on Protein: 1037-1229
Range on HMM: 71-268/290.0
IHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKITDGKSIlNKKIYQRTLEVVDStgk
| ||..  .  ....| .|||| .|  ||| |. ...|| .||. ...|.   ||. | | .  |. ..| |... .. | . .. .  |||.|  .   
inanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekav.dddflirtLkveaq...

LATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKK----SEKPIVVQCPNGIGRSMAFIGTECLARQVEAD---PTIELTEALKHMREHRWNGIQKNFQ-
 ..|.|  ..|  |  .|||.|. ....|.|....    ...|.|| |  |.||  . |  .   ....|.   ..... . . ..|..|   .| . | 
kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqy

-L
 |
el
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1011-1244 9.6e-32 105.1 In-house 45-276 (288) alignment 
Range on Protein: 1011-1244
Range on HMM: 45-276/288.0
NKHRYPTLPCKPSTAVKVIvNGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNI
 . ||  ||.   | ||.  .     |.|| |..  ...|.| .| ||. |   .| || . |||.|||| . .|    | . | | .. |  .|||.  
trdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlct

KITDGKSILNKKIYQRTLEVvDSTGKLATrTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTE
 . . .. ..| .   .| .   .|. .   | .  .  |   |||...   . |.|.||. .|||||.. .|.||....| .   ....  |  . . .
vvkkkradidklvkvsllri.skegeekv.ivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirs

ALKHMREHRWNGIQKNFQ-LYWMTLGTMYRLIKEY
 |...||.| . || . | ||   .   . |.| |
llaklreerfkaiqtemqylyvhrcvleelllkky
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1012-1243 9.9e-32 105.0 In-house 38-273 (285) alignment 
Range on Protein: 1012-1243
Range on HMM: 38-273/285.0
KHRYPTLPCKPSTAVkVIVNGQRVPIHANWVPTPGHPH-RFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNI
  ||  . |   | | |. | .|  |||.|.  ||. .  .| ||||| .|  ||| |. |  . ...||   .|  . ||  | | .. |  |.|...|
lnryadvrcieetrv.vlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyei

KITDGKSILNKKIYQRTLEVVDSTGKLATRTVM-HYQYAGWTARGVPKSHAEMFDLMEMLKK---SEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTI
 .|. |          .| |...    .    | | |   |  .  |.    | .| . .||    ||||.|.|  |.||. .|.| .  . ..  .| |
tlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpni

ELTEALKHMREHRWNGIQKNFQLYWMTLGTMYRLIKE
|. . .. ||  |.. .|  .|. .. .  |  .| |
emldivremramrfqavqshmqflflyvvlmeyfige
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1010-1229 1.2e-31 104.9 In-house 47-269 (318) alignment 
Range on Protein: 1010-1229
Range on HMM: 47-269/318.0
KNKHRYPTLPCKPSTAVKVIVNGQR---VPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHisEPFKIG
|.| ||  .    .| ||.    .      | ||...   . . .| .|.|| .|  ||| |. . .   |||| | .|.  .|.. | | .  .. ..|
kaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsyg

RFNIKITDGKSIlnKKIYQRTLEVVDsTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSE-----KPIVVQCPNGIGRSMAFIGTECLARQVE
.  ..... ...  ..   |...|   |.. ..|.|  |.|. |. .|||.| |.. ||.   .| .     .|||| |  |.||   ||  . | ....
klvvelkeevel..sdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerik

ADPTIELTEALKHMREHRWNGIQKNFQL
|. .... .  |..||.|   .| . | 
aealvDvfqtvkqlreqrnlmvqtedqy
subfamily_PTPN9_pd Subfamily PTPN9 1009-1231 3.3e-31 103.4 In-house 42-281 (297) alignment 
Range on Protein: 1009-1231
Range on HMM: 42-281/297.0
PKNKHRYPTLPCKPSTAVKVI-VNGQRV--PIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKI
  .| ||  . |  .| |..  |...     |.||.|    ... || ||||||.|  |||.|. . .|  |||  . .|.  .||  | |..  .  . 
nleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaef

GRFNIKITDgksILNKKIYQRTLEVVDSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKK-----------------SEKPIVVQCPNGIGRSM
| ....  .   . ... |. .  ... . .  .|.|.|.|. .|   |||.| |...|..|. ..                 |. |||| |  ||||. 
gdlsvsnve...veeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtG

AFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYW
.||  .    ..|   |....|..|..|. |   || . | ..
tfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyef
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1035-1228 4.6e-31 102.8 In-house 58-254 (283) alignment 
Range on Protein: 1035-1228
Range on HMM: 58-254/283.0
VPIHANWVP---TPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFkiGRFNIKITDGKSilNKKIYQRTLEVV
  | | ..|      . ...|..|.||..|. ||| |. . ..  |||| . .|.| .||  | | . || .  | | . . .  .  ..   .. | . 
dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy..Geftvtlrkett..snsfiikelllr

DSTGKLATRTVMHYQYAGWTARGVPKSHAEM--FDLMEMLKK--SEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNF
 ..   .|  . |||. .|.  |       .  |...  |..   . |||| | .||||. .||.  .   .. ..  ... . .| |||.|   .|.  
vnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtld

Q
|
q
0051429 (Phosphotyrosine protein) phosphatases II 1037-1235 1.1e-30 102.6 In-house 7-220 (272) alignment 
Range on Protein: 1037-1235
Range on HMM: 7-220/272.0
IHANWVPTPGH---PHRFIVTQGPLKNTRYDFWMMlTQYDVEHIVMLGQNMENLIVKCDYYIP----------PHISEPFKIGRFNIKITDGKSILNKKI
|.|..|...|.   |.|.. ..|||..|  ||| .  .... .||.| . .|   .|||.|.|          ..  ..  .|.. ....  .  |.  .
iNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyil

YQRTLEVVDSTGKLatRTVMHYQYAGWTARGVPKSHaeMFDLMEMLKKsEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIE--------LTEALKHM
.  .|. . |.|.   |.|||..| .|  .|||..   . .|.|.| . ..|..| |  |..|.  ..    |...|...  ..        | ||....
rellltlllsagea..revmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

REHRWNGIQKNFQLYWMTLG
|..| . .|   |...    
raqrpgavqteeqylflyea
subfamily_PTPN1_pd Subfamily PTPN1 981-1231 1.6e-30 100.9 In-house 5-262 (290) alignment 
Range on Protein: 981-1231
Range on HMM: 5-262/290.0
AKFYNTTIENVNVTTIdkdHITESYAYLPKNKHRYPTLPCKPSTAVKVIV-NGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVM
 ..|.. .....  .    ... . | ||.|. .      .|    .... ...   | |. |  .   ...|.||||| ||   || |. . .   .||
krlykeiyldirkeas...dfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LGQNMENLIVKCDYYIPPHIS-EPFKIGRFNIKITDGKSILNKKIYQRTLEVVDSTGKlATRTVMHYQYAGWTARGVPKSHAEMFDLMEML------KKS
| . .|.  .||  | | . . . ...   ..|..  .   ...   |.||. . . .  ||...|. |  |.  |||.| | .....  .      .. 
lnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktq.etreilhfhyttwpdfgvpespaaflkflfkvresGslssd

EKPIVVQCPNGIGRSMAFIGTECLARQVEADPT---IELTEALKHMREHRWNGIQKNFQLYW
  | |. |  ||||| .|.  ...  ..|.      ... . | ..|..|   ||   || .
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1037-1244 1.7e-30 101.2 In-house 49-263 (290) alignment 
Range on Protein: 1037-1244
Range on HMM: 49-263/290.0
IHANWVPTPgHPHRFIVTQGPLKNT-------RYDFWMMLTQYDVEHIVMLGQNMENLIV----KCDYYIPPHISEPFKIGRFNIKItdGKSILNKKIYQ
|||| |  | .  |.|.|| |....         .|| |  |  |...|||....|.        |  |.| .. |  |.. ...|    . . .. . .
iHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC..kskekeddvet

RTLEVvdSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTEcLARQ-VE-ADPTIELTEALKHMREHRWNGI
|.|.|    ..    || |... ||. . |....  . .|....|.|. |..| | .|| || |.   . |. | .      ..|...|| .|..| . |
Relvv..kfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaii.lgyQkiaetsgsvkledvlkalrkqralai

QKNFQLYWMTLGTMYRLIKEY
... .| ..  | . ..|...
tsalelafvdagivllaievl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1037-1229 1.8e-30 100.9 In-house 79-272 (290) alignment 
Range on Protein: 1037-1229
Range on HMM: 79-272/290.0
IHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPfkIGRFNIKITDGKSiLNkKIYQRTLEVVDSTGK
|.| ..    . ...|.||||..||  ||| .. | .|  |||| . .|.  |||  | | . ..   .| |.||... .. || .. .|.||| ... .
inAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneet.ln.eyierklevknknsa

LATRTVMHYQYAGWTARG-VPKSHAEMFDLMEMLK----KSEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQL
 |...|..||   |   | |.. .. .  . || |    . ...||| | ...|||  |. ..    ... .  |.. . ||..|  . . .| . |.
gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqy
subfamily_PTPRK_pd Subfamily PTPRK 1035-1228 7.4e-30 98.8 In-house 72-265 (314) alignment 
Range on Protein: 1035-1228
Range on HMM: 72-265/314.0
VPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEpfkIGRFNIKITDgkSILNKKIYQRTLEVVD-S
  | |... .  .|. ||||||||..| .||| .. ...   |||| . .|.  |||  | | . .     | ..... .  . |.... .|.. |   .
dyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelve..tellaelvvrifrvekla

TGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSE----KPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQ
 |. ..|.| ..|. ||.. .||.|   ...|.  .|||.     .||| | .| ||. .||  . .   .| . .... .| | .|... | .. . |
rgqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeq
0043147 (Phosphotyrosine protein) phosphatases II 1036-1232 3.3e-29 97.2 In-house 7-153 (172) alignment 
Range on Protein: 1036-1232
Range on HMM: 7-153/172.0
PIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNmenlivkcdyyipphisepfkigrfnikitdgksilnkkiyqrtlevvDSTG
 |.|...... .|.|||.||||| ||  ||| || .... |||.| .                                                   ..
yinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................lydp

KLATRTVMHYQYAGWTARGVPkSHAEMFDLMEMLKK-----SEKPIVVQCPNGIGRSMAFIGTECLArqveadPTIELTEALKHMREHRWNGIQKNFQLY
.| .|....|.| .|   ||| . . . ...| ...     ...|..| |  |.||. ...    .         . | ||....||.|....|   |..
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

WM
. 
fl
subfamily_PTPN23_pd Subfamily PTPN23 1044-1230 4e-29 96.4 In-house 79-270 (288) alignment 
Range on Protein: 1044-1230
Range on HMM: 79-270/288.0
TPGHPhRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKITDGKSIlnKKIYQRTLEVvDSTGKLATRTVM
.|| |  ||.||.||..|  |||.|. .  .. |||| .. |    |.| | | .  |. | | ... . . ..   ..  .|.|.. .  .. |...|.
spgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret..ethvervlkl.etldadavksvs

HYQYAGWTARGVPKSHAEMFDLMEMLKK--------SEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTI-ELTEALKHMREHRWNGIQKNFQLY
| |.  |.  |||.|  .......  ..        |..|.||.|  |.||. .|    . .|..|... . .. . ....|| | . .|.. || 
hlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk
subfamily_Ptp69D_pd Subfamily Ptp69D 1035-1264 1e-28 95.4 In-house 77-304 (307) alignment 
Range on Protein: 1035-1264
Range on HMM: 77-304/307.0
VPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHisEPFKIGRFNIKITdgKSILNKKIYQRTLEVVDST
  | |... .  . ..||. |.|. .|  ||| |... .|. |||| .  |    ||. | |    .  . |  ..|.   ..   ..  .|.|.|    
dYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklv..seekhsdyiiReldvskkk

G----KLATRTVMHYQYAGWTARGVPKSHAEMFDLMEML----KKSEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRwNGIQKN
       ..| |. |.| ||    ||..   ...|.|..    |... |||| | .| |||  |.  . |  |..|. .... |  |..|..| | . ..
eesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqR.nllvqs

FQLYWMtlgtMYRLIKEYGFDmKIYDQQMAIFSDVVDR
.. |      .|| . .|       |...  ..| ..|
leqYvf....lyralldyssy.gdtdedvddledaier
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1046-1230 2.7e-28 93.8 In-house 49-232 (250) alignment 
Range on Protein: 1046-1230
Range on HMM: 49-232/250.0
GHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVkCDYYIPPHISEpfKIGRFNIKITDGKSilNKKIYQRTLEVVdSTGKLATRTVMHY
   . ||.|||||..|  ||| |....... |||| .  |.  . .  |.|   .|  | |   ... . .      . .|.| .  .. |   |.| ..
derkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae..kyGdvtvsllskee..fadytkrklkls.kakkaderivrql

QYAGWTARGVPKSHAEMFDLMEMLKKSE-----KPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLY
..  |  .|||.    ...|.. ...|.     .|..||| .|.||| |||  ...  ... . .... . .| .|..| . .. . |  
hfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1063-1231 3.9e-28 93.2 In-house 42-212 (255) alignment 
Range on Protein: 1063-1231
Range on HMM: 42-212/255.0
YDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKITDgksiLNKKIYQRTLEVVDSTG-KLATRTVMHYQYAGWTARGVPKSHAE
  |. .. | . | .|||.   |. ..||. |.|    |  |.   |.  |.       ..  ||||..   | |  |.|| ||.| || ..  |.   |
dkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

MFDLMEMLKKSeKPIVVQCPNGIGRSMAFIGTECLAR----QVEADPTIEL--TEALKHMREHRWNGIQKNFQLYW
.  .. . ..| |..||.| .||||| ||. .| . .    ...  .|.||   . |...|..|   |.. .|| .
ilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1010-1229 4e-28 93.3 In-house 29-257 (274) alignment 
Range on Protein: 1010-1229
Range on HMM: 29-257/274.0
KNKHRYPTLPCKPSTAVKVIVNGQRV----PIHANWVPTPGH-PHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFK
..| || |.   . . | .  . ..      | ||..  ...  . .. ||||| ||  ||| |. | .|. |||| .  |.   ||  | | ...   .
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

IGRFNIKITDgKSILNKKIYQRTLEVVDSTGKlaTRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSE-------KPIVVQCPNGIGRSMAFIGTECLA
    ...|.  ..|.... |. .  |. .. .  .|.|.|| |. |  . .|..  ...||..  ..|.        |.|| |  ||||  .||...   
erygdveikv.ekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav

RQVEADPTIELTEALKHMREHRWNGIQKNFQL
||.... .... .   ..| .|   .|.. | 
rqlreeivvdvlkivcnlrldrGGmvqtseqy
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1032-1232 6e-28 92.6 In-house 46-256 (270) alignment 
Range on Protein: 1032-1232
Range on HMM: 46-256/270.0
GQRVPIHANWVP-TPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKITDGKSILNKKIYQRTLEV
 .   | ||.|.   |.....| ..|||..|  .|| |. .  |. |||. . .|.   ||. | |..  |  |.   .||..  ..  ..   .. |..
sataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrl

VdSTGKlaTRTVMHYQYAGWTARGVPKSHA---EMFDLMEMLKKS-------E--KPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREH
  ..|.  .| ..|..|  |  .|||...    .  .|..||..        .  .|..| | .|.||.  .| ..   | .| .  ..... ....|..
e.ekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkd

RWNGIQKNFQLYWM
| . .|.  |  ..
Rmalvqhpeqyefl
WSN Domain of unknown function 40-106 3.2e-27 84.2 Pfam-A 2-68 (69) alignment 
Range on Protein: 40-106
Range on HMM: 2-68/69.0
KPTDYLEHITIIAHIANGITLQAGLMNGSIPINEVVGEMLNLGSANVSDLINYKPDKILELIKKLKE
.....||...|||...|||.|||||.||||||..|. |.||.||...|.|.....||. | ..||.|
elqtvleklsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnklse
subfamily_PTPRG_pd Subfamily PTPRG 990-1232 3.8e-27 89.7 In-house 27-279 (563) alignment 
Range on Protein: 990-1232
Range on HMM: 27-279/563.0
NVNVTTIDKD-HITESYAYLPKNKHRYPTLPCKPSTAVKVI-VNGQRVP---IHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNM
... .||.|| ... | .   |.| ||  .    .. ||.  . |.      | ||..    . . ||.||||||.|  ||| |. .  |. |||. .  
alqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlv

ENLIVKCDYYIPPhiSEPFKIGRFNIKITDGKSILNKKIyqRTLEVVD-----STGKLATRTVMHYQYAGWTARGVPKSHAemFDLMEMLKKSE------
|.   ||| | |    |. ..| ....... . .    .  ||| . .        .   ..|..|.|. |   |||.. .  ..|. . |.|       
ergrrkcdvYWPk..desetygalqvtlieeevlalytv..rtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl..pvLifvkkssaankaea

KPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWM
 |||| | .|.||.  .|  . | .|.... .... . |||.| .| . .|.. | ...
GPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYifl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1036-1228 9e-27 88.8 In-house 79-267 (315) alignment 
Range on Protein: 1036-1228
Range on HMM: 79-267/315.0
PIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHisePFKIGRfnIKITDGKSILNKKIYQRTLEVVDstg
 . ||...   ...|.| .|||. ..  ||| .. ..|. .|||| . .|.   |.. | | .       |.  | .|  .   |...  ||| ||    
yvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGk..itvtrkseevnteytvrtlsvvf...

KLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKK----SEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQ
.   |.|. ..|. |   ||||.   . .|.   |.    |  .||| | .|.||. .||  ...  |.||.  |.. .... .|. | . .|   |
gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeq
0049260 (Phosphotyrosine protein) phosphatases II 1044-1231 6.4e-26 86.3 In-house 4-141 (152) alignment 
Range on Protein: 1044-1231
Range on HMM: 4-141/152.0
TPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIpphisepfkigrfnikitdgksilnkkiyqrtlevvdstgklatrtvm
  ..|..|| ||||. ||  ||| || .... .|||| . .|.  .||..||                                                
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................

HYQYAGWTARGVPKSHAEMFDLMEML----KKSEKPIVVQCPNGIGRSMAFIGTECLArqveadPTIELTEALKHMREHRWNGIQKNFQLYW
.|..  |   |||...  . .|....    .....|..| |  |.||. ...    .         ..| ||....||.|.....   ||..
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1036-1234 6.5e-26 86.5 In-house 55-249 (284) alignment 
Range on Protein: 1036-1234
Range on HMM: 55-249/284.0
PIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGqnmenlIVKCDYYIPPHISEpfKIGRFNIKITDGKSILNkkIYQRTLEVVDSTG
 | | ..    .....| |||||.||  ||| |. .|..  ||.|         ||  | | .| .  | .||..|..  .   .     | .|. . . 
yinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi..keerfkvkvdsveesee..yvvrdielsedgk

KLATRTVMHYQYAGWTARGVPKSHAEMFDLMEM---L---KKSEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQL
.   |..  . . ||   |||.. .... |..    |   .. ...||| |  |.||. ..|  ..|  ... .  ... . .. .|. | . .|.  | 
ekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

YWMTL
...  
kfiys
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 994-1233 8e-26 86.1 In-house 44-284 (319) alignment 
Range on Protein: 994-1233
Range on HMM: 44-284/319.0
TTIDKDHITESYAYLPKN--KHRYPTLPCKPSTAVKVI-VNGQRV--PIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGqnmenlI
. .  .  . ..| |..|  | |.  .     . ||.  ..|.     | | .|    .. ..| .||||.||  ||| |. .|..  ||.|        
cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......k

VKCDYYIPPHISEpfKIGRFNIKITDGKSILNkkIYQRTLEVVDSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEM---L---KKSEKPIVVQCPN
 ||  | | .| .  | .||..|..  .   .     | .|. . . .   | .  . . ||   |||.. .... |..    |   .. ...||| |  
dkcsqywplkivi..keerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsa

GIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWMT
|.||. ..|  ..|  ... .  ... . .. .|. | . .|.  | ... 
GvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiy
0046846 (Phosphotyrosine protein) phosphatases II 1031-1231 8.6e-26 86.2 In-house 9-164 (176) alignment 
Range on Protein: 1031-1231
Range on HMM: 9-164/176.0
NGQRVPIHANWVPTPghphRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFkigrfnikitdgksilnkkiyqrtlev
..  . |.||.. ..    |.|.||||| .| .||. || .......|.| . .|   .||..| |   .. .                           
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

vdstgklatrtvmHYQYAGWTARGVPKShAEMFDLMEMLKKSE---KPIVVQCPNGIGRSmafiGTECLARQVEADPTIELTEALKHMREHRW-NGIQKN
             .|.. .|   ||| . . ...|.|....     .|..| |  ||||.    || ..|  .| .  . . |||...||.|. . .|  
.............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRt....gtlvaayllelekglsveealalvreqRplgavqtp

FQLYW
 |...
eQyrf
subfamily_hpo-7_pd Subfamily hpo-7 1064-1231 8.8e-26 85.4 In-house 49-218 (263) alignment 
Range on Protein: 1064-1231
Range on HMM: 49-218/263.0
DFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKITDGKSilnkKIYQRTLEVVDSTG-KLATRTVMHYQYAGWTARGVPKSHAEM
 |. .. |   | .|||.   |. ..||. | |    |  |.   |.  |. .|    ..  .|||..   | |  |.|| ||.| || ..  |.   |.
kfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhysykgWiekndpelarei

FDLMEMLKKSeKPIVVQCPNGIGRSMAFIGTECLAR----QVEADPTIEL--TEALKHMREHRWNGIQKNFQLYW
. .... ..| |..|| | .||||| ||  .| . .    ...  .|.||   . |...|..|   |.. .|| .
lnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 979-1229 2e-25 84.5 In-house 23-273 (297) alignment 
Range on Protein: 979-1229
Range on HMM: 23-273/297.0
KTAKFYNTTIENVNVTTIDKDHITESYAYLPKNKHRyPTLPCKPSTAVKVIVNGQ--RVPIHANWVPtpGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEH
. .....  .  .  ..| ..  .|    ..|....   || . |     ||| .     . | .|.  |  ||.| || | |.|  ||| |. ...|  
rhtdvfseeflclpeaniqpqtvaekkvnfeksRYk.niLPydssRvkLaivnddpdsDyvnasfvk..gnkhrlittqmPmkatvadfWamvldeqvst

IVMLGQNMENLIvKCDYYIPPHISEPFkiGRFNIKITDGKSilNKKIYQRTLEVVDSTGKlATRTVMHYQYAGWTARGVPK--SHAEMFDLMEMLKK---
|||| .. |.   ||  | . . . .|  |   ....  ..   .   .|.|||  .  | |.| |  ||.  |  . |..  | . . .|.. ..|   
ivmlnddnerdk.kcaryWsdkgvttf..Gdvsvvllsvse..reGfikrelevtkgkak.arrvvkqyqfveWPdkaverkdsassllklisevrkdfs

--SEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQL
  .| |..| | .|.||   ..  .    ... . .... . .|..|..| . .| . | 
qnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqy
0036282 (Phosphotyrosine protein) phosphatases II 1037-1231 3.5e-25 84.1 In-house 5-161 (174) alignment 
Range on Protein: 1037-1231
Range on HMM: 5-161/174.0
IHANWVPTPGHPHRFIVTQGPLKntrydFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPhisepfkigrfnikitdgksilnkkiyqrtlevvdsTGK
|.|...     . |.|..||||.     || || .......||| . .|. ..||  | |                                     . .
inaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................lre

LATRTVMHYQYAGWTARGVPKSHAeMFDLMEMLKKS-----EKPIVVQCPNGIGRSMAFIGTECLARQVEaDPTIELTEALKHMREHRWNGIQKNFQLYW
  .|....|.| .|  .||| ..  ...... ...      ..|..| |  |.||. ....   . |. .  ....  . .. .| .| ...|   |...
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1009-1218 1.4e-24 81.3 In-house 37-246 (281) alignment 
Range on Protein: 1009-1218
Range on HMM: 37-246/281.0
PKNKHRYPTLPCKPSTAVKVIV---N-GQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFK
 ..| ||  .||   . |.. |   |      ||||.. .|   . .|.|||| |.|| ||| |. | .   |||| | .|    ||  |.|      ..
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclq

IGRFNIKITDgkSILNKKIYQRTLEVVDsTGklATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTECLARQVEADP
. .. ..  |  | .|| .    |..    |   || . |. .  |    ||.|   |. ..  ..    | |..|  |.||| ...  |   . . .  
fdklsvsyed..stvnkslvttrlnlsy.eg..etrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshf

TI-ELTEALKHMREH
|. .. . . |.|  
tlpdikqivshlrvt
subfamily_PTPN6_pd Subfamily PTPN6 1008-1230 1.6e-24 81.5 In-house 96-287 (306) alignment 
Range on Protein: 1008-1230
Range on HMM: 96-287/306.0
LpknkhryptlpckpstavkvivngqrvpihanwvptpghPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFkIGR
                                         ...| ||| |..|  ||| |. | . . |||. ...|    ||  | | . ...   |.
s.......................................dksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGk

FNIKITDGKSilNKKIYQRTLEVVDSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKS--------EKPIVVQCPNGIGRSMAFIGTECLARQ
 ... .. ||  ...   |.| |   . |  .|.|..|..  |   ||||.   . |..| ...         . |||| | .||||  .|| ...| ..
isvtnvseks..ladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkl

VE---ADPTIELTEALKHMREHRWNGIQKNFQLY
.|    |  |.. .. | .||.|   .| . |  
iekkgldadidiqklvksvreqrsglvqteqqyk
subfamily_PTPRA_pd Subfamily PTPRA 1037-1244 1.7e-24 81.3 In-house 89-294 (330) alignment 
Range on Protein: 1037-1244
Range on HMM: 89-294/330.0
IHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISepFKIGRFNIKITDGKSILNKKIYQRTLE-VVDSTG
| | ..    . ..|| .|||...|  ||| |. ...   |||| .  |    ||  | | . .  .  |  .... | . . .  . .  .. . |.| 
inasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl..vtyGnirvevedetvlvdytvrkflvqqlpdatr

KLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSE----KPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYW
. ..| |  . . .|   |||     |..|.. .|| .     |||| |  |.||. .||  . .  .|.|.  ... |..|..|  | . .| . |  .
ekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyef

mtlgtMYRLIKEY
     .|. ..||
.....iykvlley
subfamily_CG7180_pd Subfamily CG7180 1037-1225 3.7e-24 79.9 In-house 73-275 (296) alignment 
Range on Protein: 1037-1225
Range on HMM: 73-275/296.0
IHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIvKCDYYIPPHIsePFKIGRFNIKITDGKSILNK-----KIYQR--TLE
| | .| .  ... .|||..| |.|  .|| .. . ... .|.| ....    ..  |.|..    .. | . ..|.  |.  |      |....  .| 
inavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalt

VVDSTGKLATRTVMHYQYAGWTA-RGVPKSHAEMFDLMEMLK----KS-----EKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHR
  .   |  ||.|...|.  |     || | . . .|... .    |      |.|.|| ...| .|| .... .    .|| .  ... ||.| .|..|
eqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsR

WNGIQK
 . ...
pqLven
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 993-1261 9.6e-24 78.6 In-house 28-295 (312) alignment 
Range on Protein: 993-1261
Range on HMM: 28-295/312.0
VTTIDKDhiTESYAYLP-KNKHRYPTLPCKPSTAVKvIVNGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKC
|  |  |  .|  |.|  |.  ||| . |        .   .   ||||.|    .| ||..|||||.||   || .        |..|   .|.   ||
vgnivsd..sectaflkfkdlnrypniqcwdrgrft.lagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekc

DYYIPPHIS----EPFKIG-RF--NIKItDGKSilNKKIYQRTLEVV-DSTGKLAtrTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEKPIVVQCPNG
  ||   ..    |  ..   .  .|.|  |||  . || .| | ||  .||. .   . |||.| |   |.| |    . |.  .||  ||.. .|  |
akyisdivgfvdledhrvyteycteiei.ggks..kdkithrvlkvvvkatgqes..klnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsag

IGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKnFQLYWMTLGTMYRLIKEYGFdMKIYDQQMAIFSDV
.||. ...  | .   .      .. ...  .|  |   ..  |  | ..| ..  ..   |. .|  .|... | ..
vgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrv.fpqyvyalrcvleflyskgl.ykrneqewtkfket
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 997-1228 1.1e-23 78.6 In-house 34-265 (315) alignment 
Range on Protein: 997-1228
Range on HMM: 34-265/315.0
DKDHITESYAYLPKNKHRyPTLPCKpSTAVKV--IVN-GQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDY
 . ...      .||...   || . |. ||.  | .  ..  | |  ...  . . .| .||||| .  ||| |. |..|  |||. .  |.  .||  
yrqrvaretinfkknryk.nilPld.sarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YIPPHISEPFKIGRFNIKITDGKSILNkkIYQRTLeVVDsTGKlATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKS----EKPIVVQCPNGIGRSMA
| | . ..  . | ..... . ..  .    .| | |.   .. ..|||  .|. .|  .||.|  . .. |.  .| .    | ...| |  |.||.  
ywPdrkadsvefGsikvellsleadtd..gvarkl.vtr.kse.esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGv

FIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQ
.|  .    |..   .... . .| .|..|   .| . .
visidevvaqikrtrsvdvfnfvknlrakrpylvqteee
subfamily_egg_pd Subfamily egg 995-1228 1.7e-23 77.8 In-house 26-258 (307) alignment 
Range on Protein: 995-1228
Range on HMM: 26-258/307.0
TIDKDHITESYAYLPKNKHRYPTLPCKPSTAVKV-IVNGQRV--PIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENliVKC
..|.  .|....   ..| | . ..|| |. ||. . .|| .   |||| |        ||..| |||||  ||| |. | .|..||||  . |.   .|
svdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erc

DYYIPPHISEPFKI--GRFNIKITDGKSILNKKIYQRTLEVVDSTgkLATRTVMHYQyagWTARGVPKSHAeMFDLMEMLKKSEKPIVVQCPNGIGRSMA
.|| |   |.. ..  | ..|.  . .|  .       | .| .      | . |.|   .  . . . .   . .. .|..  ||.|||. .|. .. .
eyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwq...gdvnnssdvys.plrvlrklrnlskpvvvqdilGvskaat

FIGTECLARQVEADPTIE--LTEALKHMREHRWNGIQKNFQ
..  |    ..   |.    . .| . .| .|   ..  ..
lvaieiallsllrGpitkslvlravvflrlrrrlsvesvll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1005-1228 2.7e-23 77.6 In-house 42-276 (325) alignment 
Range on Protein: 1005-1228
Range on HMM: 42-276/325.0
YAYLPKN--KHRYPT-LPCKPSTAVKVIV--NGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLgQNMENLIVKCDYYIPPHI
 | .|.|  | |..  .. . | .| .    ...   | |... .    . |. .| || .|  |.| .. ..    .|.|   ...   .|  | | ..
vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl.neldlgkdrcavywpkem

SEPFKIGRFNIKITDGKSIlnKKIYQRTLEVVDSTgKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLK----------KSEKPIVVQCPNGIGRSMA
..  . | ...|.   . |      .| |.| .   |  ||.|  .|. .|   ||.|  | .  .....|          |.  ||.| | .|.||. .
gksktfGglevklrtieei..sdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

FIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQ
||   ... .|  .  ... . .|..|..| . ..   |
fislysalakvieesrvdifgfvkklrkdrpsmvetvdq
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1013-1228 2.7e-23 76.8 In-house 47-264 (515) alignment 
Range on Protein: 1013-1228
Range on HMM: 47-264/515.0
HRYP-TLPCKpSTAVKV-IV--NGQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRF
 ||   || . |. ||. ..  | .   . |  .|.    . .| .|||.| .  ||| .. |..|  |.|. .  |.  .||  | | . ..  | | .
nryknilPyd.svrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsi

NIKITDGKSILNkkIYQRTLEVVDSTGklaTRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKS----EKPIVVQCPNGIGRSMAFIGTECLARQVEADP
....   ..  .    .|.|.|. .     .|||  ... .|  .||||    .. |.  .| .    . |... |  |.||   .|  .    ...   
kvelvsleactg..gikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttr

TIELTEALKHMREHRWNGIQKNFQ
.... . .. .|..|   .| . |
mvdvfnfvtnirqkrpylvqtqeq
subfamily_PTPN14_pd Subfamily PTPN14 1042-1226 1.5e-22 74.9 In-house 86-282 (300) alignment 
Range on Protein: 1042-1226
Range on HMM: 86-282/300.0
VPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEP--FKIGRFNIkiTDGKSILNKKIYQRTLEVVDSTGKlAT
|.  |. . .||.||||..|  ||| |. . .|. |||| .. |.   |.  |.| . |.    . |.|..  |   |   ...  ..|..     |   
vsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkv..ttkfsedsdsvittglklkhlpsk.ee

RTVMHYQYAGWTARGVPKSHAEMFDLMEMLKK-------------SEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKN
|||.| ||. |. .|||.   .... .|...              |. |..| | .|.||.   | .. |   .| . .|.. ..|...|| |   .|  
rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtl
0049772 (Phosphotyrosine protein) phosphatases II 986-1238 3.6e-22 74.9 In-house 23-273 (314) alignment 
Range on Protein: 986-1238
Range on HMM: 23-273/314.0
TTIENVNVTTIDKDHITESYAYLPKNKHRYPTLPCKPsTAVKVivNGQRV----PIHANWVPTPghpHRFIVTQGPLKNTRYDF----------WMML--
 .. ... ... . .|. .. .| ..| ||.  .. . . |..  .|. |     |.|..| ..    .||.|||||..| .||          | |   
lvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil..pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlr

TQYDVEHIVM---------------------LGQNMENLivkcdyyipphiSEPFKIGRFNIKitdgksilnkkiyqrtlEVVDSTgKLATRTVMHYQYA
 ...|  |||                     | . ..|             .||      ..|                 |....  .| .|....| . 
gdlnvrdivmsrdevladelsrLdaAlgKtpllildgng............neptaadlellk.................eelydp.elferlgikylri

GWTARGVPkSHAEMFDLMEMLKK--SEKPIVVQCPNGIGRSMAFIGTECLARQVeadpTIELTEALKHMREHRWNGIQKNFQLYWMTLGTMY
 ..  ..| . . . ...|....   ..|..| |  |.||.  |. . .| ..      . | |||...|. |  .....|    . .  ..
pvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefil
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 992-1231 2.5e-21 70.7 In-house 38-268 (287) alignment 
Range on Protein: 992-1231
Range on HMM: 38-268/287.0
NvttidkdhitesyaylpKNKHRYPTLPCKPSTAVKVIVNGQRV--PIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIV
.                  .| ||  .     | | .  .|.     | ||.|..  . ..||..|||.  |  ||| .. .  .  .... ...|.   
a.................vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearl

KCDYYIPPHiSEPFKIGRFNIKITDgKSILNKKIYQRTLEVVDSTGKLAtRTVMHYQYAGWTARGVPKSHAE----MFDL---MEMLKKSE--KPIVVQC
||  | | .   | ..| . . . | ..|.. .   |.| ..|  .. | | |  ...  | ..... .       ..|    .|. ....   |.|| .
kcykywPer.evPmrvGGysvvlld.ydikePeygvralrlidletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

PNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYW
  |||||  .. |  | .. |    .. . .. ..||.|   .|   ||  
dvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrl
0051082 (Phosphotyrosine protein) phosphatases II 1036-1231 2e-20 68.4 In-house 5-144 (151) alignment 
Range on Protein: 1036-1231
Range on HMM: 5-144/151.0
PIHANWVPTPghphrFIVTQGPLKntryDFWMMLTQYDVEHIVMLGQNMENLivKCDYYIPPHIsepfkigrfnikitdgksilnkkiyqrtlevvdstg
.|....|        .....|||     ||. .| .... .||.| . .|.   .|  | | .                                     
yinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................................

klatRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKS-EKPIVVQCPNGIGRSMAFIGTECLARQveadptIELTEALKHMREHRWNGIQKNFQLYW
    ..|.|... .|.. |.| | ... ...|.| .  ..|..| |  |.||. ....  .....      . | |||...|..|.. .| | | . 
....ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf
0044763 (Phosphotyrosine protein) phosphatases II 1032-1233 7.7e-20 66.7 In-house 16-164 (178) alignment 
Range on Protein: 1032-1233
Range on HMM: 16-164/178.0
GQRVPIHANWVPtpghPHRFIVTQGPlkntrYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISepfkigrfnikitdgksilnkkiyqrtlevv
    .|.|...     |. .. ...|      |.. .| .... |||.| ...|.  .||| | |   .                               
ersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............................

dstgklatrtvMHYQYAGWTARGVPKSHAEMFDLMEMLK----KSEKPIVVQCPNGIGRSMAFIGTECLARQveadpTIELTEALKHMREHRWnGIQKNF
           ..|.. ..   ||| . . .....|...    ....|..| |  |.||| ...    . ..      . | ||....||.|. ...   
...........iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg

QLYWMT
||... 
qlrqLy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1046-1234 1.6e-19 65.0 In-house 48-234 (239) alignment 
Range on Protein: 1046-1234
Range on HMM: 48-234/239.0
GHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEpfkigRFNIKITDGKSILNKKIYQRTLeVVDSTGKLATRTVMHY
| |. .| ||| .. .  ||| |. |     ||||   .|    ||  | |   |.       |...|  |. .      ||. |.   |.   | | .|
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.....ycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqy

QYAGWTARGVPKSHAEMFDLMEMLKKS----EKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWMTL
... |  .|||.  . .. |   . |      .| |..|  |.||. ||.  ... || . . |... . .| .|| |   .| . |  .. |
hftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1046-1233 1.8e-19 64.9 In-house 49-234 (239) alignment 
Range on Protein: 1046-1233
Range on HMM: 49-234/239.0
GHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEpfkigRFNIKITDGKSILNKKIYQRTLeVVDSTGKLATRTVMHY
| |. .| ||| .. .  ||| |. |     ||||   .|    ||  | |   |.       |...|  |. .      ||. |.   |.   | | .|
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.....ycnlrvtlrktevfadyiirtf.vmsqvgqteeryvyqy

QYAGWTARGVPKSHAEMFDLMEMLKKS----EKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWMT
... |  .|||.  . .. |   . |      .| |..|  |.||. ||.  ... || . . |... . .| .|| |   .| . |  .. 
hftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1045-1229 2.5e-19 64.4 In-house 41-228 (237) alignment 
Range on Protein: 1045-1229
Range on HMM: 41-228/237.0
PGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPpHISEPFKIGRFNIKITDGKSILNKKIyqRTLEVVDSTGKLATRTVMH
 | |...| .||||...  ||| |. |     ||||   .|.  .||  | |    .|   | . . ..  . . .  .  |.| ..  . .   | .  
dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaaygvltvslkkkeefsdytv..rslllskrltlkevrlihq

YQYAGWTARGVPKSHAEMFDLM-EMLKKSEK-----PIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQL
||.. |  ||||.  | .. .  .....|..     | .. |  |.||.  |.  ... || .    ... . .. . | |   || . | 
yqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqy
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1033-1220 1.1e-18 62.0 In-house 69-273 (301) alignment 
Range on Protein: 1033-1220
Range on HMM: 69-273/301.0
QRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKITDGKSILNKKIYQRTLEVVD
||  | |...    . ..||..|||.|.|  ||| .. |. . .|||. .  |.   ||  | |    |  . | |...... . . .  | | .. . |
qreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqd

STG------------KLATRTVMHYQYAGWTARGV---PKSHAEMFD--LMEMLKKSEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHM
...            . ....|. .| . |   ||   |.   .  |  ..   | .  |.|| | ....||  ..  .    |. |.  ... .  | .
gsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkav

REHRW
|  . 
rrskp
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 988-1224 4.3e-18 60.3 In-house 12-243 (267) alignment 
Range on Protein: 988-1224
Range on HMM: 12-243/267.0
IENVNVTTIDKDHITESYAYLPKNKHRYPTLpcKPSTAVKVIVNGQRVP-IHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMEN
 |...  . ..  |. |.|   ....|.      |    .||.  .    | | .| .    . |||||.|||||  ||. ......|  ||.| .  ..
felikkisdtsstisqsiaeknqernrlddn..lpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd

LIVKcdyYIPPHISEPFKIGRFNIKITDGKSILNKKIYqrTLEVVDStgKLATRTVMHYQYAGWTARGVPKSHA-EMFDLM--EMLKKSEKPIVVQCPNG
 | .   . ||.. .  |   . .. .  |   . .|   |||.     . ... |  | |  |      | .   .| ..  . |.. ..|.||.| .|
nirl...fwPPkmgqakkyqdltvehslekeendyqii..tlelkfk..nesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdG

IGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQ
.||| .|.  .   ...  . . .. . |...|. |   ..
vGrsGtflvidsqleraktegvsdifdflrkirsqriglvd
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1011-1232 9.7e-18 58.8 In-house 54-282 (310) alignment 
Range on Protein: 1011-1232
Range on HMM: 54-282/310.0
NKHRYPTLPCKPSTAVKVIVNGQRV--PIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPP-HISEPFKIGR
 | ||  . |. .. ||. ..  |    ||||.| |      ||..||||. |  ||| |. |   | |..| . .|.   ||  | |   ..| .   |
hknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcir

F-NI-KITDGKSILNKKIY--QRTLEVVDSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTECLARQVEAD
  |. . ..   | |  .      . | .   .|    |   ..  |  ||||  .        . .    | ||.|  |..|  . .  .    ...  
vtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrg

PTIELTEALKHMREHRWNGIQKNFQLYWM
  ... |   ... .|   || ..|  ..
lkvdaeevktellksraiciqtelqylii
subfamily_PTPRN_pd Subfamily PTPRN 1050-1228 3.3e-17 57.2 In-house 101-280 (297) alignment 
Range on Protein: 1050-1228
Range on HMM: 101-280/297.0
RFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIgrFNIKITDgKSILNKKIYQRTLEVVDsTGKLATRTVMHYQYAG
 .| ||||| .|  ||| |. .  |  ||.| .  |. . .|. | | . || ..|  .....   . |  .    |.. . .   .  ||||  . .  
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhi..yevhlvs.ehiwcddylvrsfylkn.lqtsetrtvtqfhfls

WTARGVPKSHAEMFDLMEMLKKSE----KPIVVQCPNGIGRSMAFIGTECL-ARQVEADPTIELTEALKHMREHRWNGIQKNFQ
|...||| |   ....   . ||      |||| | .| ||. ..|  . . .| .     |... .|.|.|. | . .. . |
wpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdq
subfamily_ptpA1_pd Subfamily ptpA1 1037-1194 6.1e-17 56.4 In-house 78-250 (418) alignment 
Range on Protein: 1037-1194
Range on HMM: 78-250/418.0
IHANWVPTpGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHIS-EPFKIGRFNIKITDGKSI-LNKKIYQRTLEVVDST
| ||..    .|..||.||||| ||  ||| |. .  .  |||| .. ||  .||| | | .|  | | |     ..    |. | . | .   |..   
inanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrn

GKL----ATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLK--------KS--EKPIVVQCPNGIGRSMAFIGTE
 .|     || . .||| ||  . .|     . .|.  .          |  . ||.|.|  |.||. .|  . 
irltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctav
PTPc_DSPc_SM00012 1141-1229 7.4e-17 56.8 In-house 1-96 (105) alignment 
Range on Protein: 1141-1229
Range on HMM: 1-96/105.0
TVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEK------PIVVQCPNGIGRSMAFIGTECLARQVEAD-PTIELTEALKHMREHRWNGIQKNFQL
||.||.| ||.  |||..  ....|.. .||...      |.||.| .|.||.  |.  ..| .|.|.   .... . .|..|..| . .| . | 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1012-1159 1.7e-16 54.9 In-house 36-183 (297) alignment 
Range on Protein: 1012-1159
Range on HMM: 36-183/297.0
KHRYPTLPCKPSTAVKVI-VNGQRVPIHANWVPTPG--HPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRF
| ||  .    .| ||.  |  .|  | |..|  |   .. ..|..||||..|  ||| .... ||  |||. .  |.   ||  | |    |  | | .
knryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdv

NIKITDGKSILNKKIYQRTLEVVDStgkLATRTVMHYQYAGWTARGVPKSH
 ..     |   ....   |...       .| | | |. .|   |||   
vveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 984-1230 2.2e-15 51.1 In-house 22-269 (439) alignment 
Range on Protein: 984-1230
Range on HMM: 22-269/439.0
YNTTIENVNVTTIDKDHITESYAY-LPKNKHRYPTLPCKPSTAVKV-IVNG--QRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVM
..   |..| |  |   |.   |    . | ||  .     | | .  . |  .   | ||..     .. .| |||| |.|  ||| .. .  . .|||
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivm

LGQNMENLIvkcdyYIPPhiSEPFKIGRFNIKITdgKSILNKKIYQRTLEVVDSTGK-LATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLK-----KSE
| . .|        | |   ..    |   ...   . |   .   | . |..   .    |||....|  |  . ||   . . |..  ..     .  
ltnlvesyk.....ywps..daevcygdiavrvd..rnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeey

KPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLY
 |.||.|  |.||. . |  .    |. ..  ...   .| .|..| . .|.  |  
gpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1056-1236 5.3e-15 49.6 In-house 98-284 (302) alignment 
Range on Protein: 1056-1236
Range on HMM: 98-284/302.0
GPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKITDGKSILNK----K-IYQRTLEVVDSTGK-LATRTVMHYQYAG
 | |.|.  .| .. ||.|  .| | . .|.   ||  |   .. . .| ||. .|  . |  |..    | .   |.|. ..  |    .||   ....
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WTARGVPKSHAEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQLYWMTLGT
|   | ||     .|..   .   | ..| | .|.||. ...           . . .| . .. .|. |.  .|.. || .. |  
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
0048076 (Phosphotyrosine protein) phosphatases II 1126-1233 5.6e-14 47.5 In-house 36-136 (145) alignment 
Range on Protein: 1126-1233
Range on HMM: 36-136/145.0
RtlevvDSTGKLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKS---EKPIVVQCPNGIGRSMAFIGTECLARqveadPTIELTEALKHMREHRWNG
       |. .| .|....|.| .|  .||| ... . ...|....    ..|..| |  |.||. ....  .. .       . | |||...|..|...
l.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpga

IQKNFQLYWMT
..   ||... 
vpnpgqlrfly
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1049-1228 1e-13 45.9 In-house 4-190 (198) alignment 
Range on Protein: 1049-1228
Range on HMM: 4-190/198.0
HRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKitdGKSILNKKIYQRTLEVV--DSTGKLATRTVMHYQ
.|.|.|| ||..|  ||| |. .    ||||. ..  |  .   .| |   |   | | ...     |.|  |  |  |  ..  ..|   .|| . |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt...tktittkpdytitaliltnnttappstreishyq

YAGWTARGVPKSHAE---MFDLMEMLKKSE----KPIVVQCPNGIGRSMAFIGTECLARQVEADPT--IELTEALKHMREHRWnGIQKNFQ
.. |  .  |.       .    |. || |     |..|.| .| | .  |.  .   |  |   |  ..| |  | .|. |  ||   .|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarc.giisslq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1049-1228 1.2e-13 45.7 In-house 5-191 (199) alignment 
Range on Protein: 1049-1228
Range on HMM: 5-191/199.0
HRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKitdGKSILNKKIYQRTLEVV--DSTGKLATRTVMHYQ
.|.|.|| ||..|  ||| |. .    ||||. ..  |  .   .| |   |   | | ...     |.|  |  |  |  ..  ..|   .|| . |||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt...tktittkpdytitaliltnnttappstreishyq

YAGWTARGVPKSHAE---MFDLMEMLKKSE----KPIVVQCPNGIGRSMAFIGTECLARQVEADPT--IELTEALKHMREHRWnGIQKNFQ
.. |  .  |.       .    |. || |     |..|.| .| | .  |.  .   |  |   |  ..| |  | .|. |  ||   .|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarc.giisslq
0048179 (Phosphotyrosine protein) phosphatases II 1136-1232 9.5e-13 43.6 In-house 43-137 (144) alignment 
Range on Protein: 1136-1232
Range on HMM: 43-137/144.0
KLATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKS---EKPIVVQCPNGIGRSMAFIGTECLArqveaDPTIELTEALKHMREHRWNGIQKNFQLYWM
   .|....|.. .|  .||| . . . ...|....    ..|..| |  |.||. ...    .         . | |||...|..|.....   ||...
efleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfL
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 976-1228 3.1e-12 40.6 In-house 15-224 (392) alignment 
Range on Protein: 976-1228
Range on HMM: 15-224/392.0
DNHKTAKFYNtTIENVNVTTIDKDHITESYAYLPKNKHRYpTLPCKpSTAVKV--IVN-GQRVPIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQY
.|...| |..  . ..    | .. ...    |.||...   || . |. ||.  | .  ..  . | ..|.    . .| .|||   .  ||| |. | 
knrhsalffe.efhdlpgpdiypqtvaqkeinlkknrykn.ilpyd.sarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqe

DVEHIVMLGQNMENLivkcdyyipphisepfkigrfnikitdgksilnkkiyqrtlevvdsTGKlATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKS
.|  |.|. .  |                                                 |.  .|||  .... |  ..|||  . .. ... .|  
nvttiamvtklkegd..............................................kgd.dartvaqfhftewPdkdvpkhtssllkfikevkad

----EKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQ
     .|....|  |.||.   |  ...  . .    ... . .  .|..|   .| . |
fGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 966-1234 5e-12 39.9 In-house 8-278 (302) alignment 
Range on Protein: 966-1234
Range on HMM: 8-278/302.0
EKWTKS---MDFKDNHKTAKFYNTTiENVNVTTIDKDHiTESYAYLPkNKHRYPTLPCKPSTAVKVIVNgQRVPIHANWVPTPGHPHRFIVTQGPLKNTR
|||..    ... .. .||.  ... .... . .| ..  ...   . .| . . .|.  |. ||.  . .   ..|  |  |   .  |..| | ... 
ekWveeeeakklvksldtaevkkef.kkidtmkvdlek.Ckafkknl.kknqsedvpildsnlvkleae.pdsyvnaskvevPeltrsiilaQlpkvdse

---YDFWMMLTQYDVEHIVMLGQNMENLIvKCDYYIPPHISEPFKIGRFNIKITDGKSILNKKiYQRTLEVVDStGKLATRTVMHYQYAGWTARGVPKSH
    .|| |  |  . ..|.| .. |      . ..| .  .  . |.. . .   ..  ..| .. ..||.   |   .  .. |    | .  ||.. 
dsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPe.gcsnsvlanvyvltnWkqkkvpvky

AEMFDLMEML----KKSEKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQlYWMTL
||.   .. .     |.....|.   ||.||  ||.       .....   . .| .| .|. | . ..   | | .. 
aeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQ.yvsly
subfamily_eak_pd Subfamily eak 1049-1186 6.4e-12 39.5 In-house 93-224 (332) alignment 
Range on Protein: 1049-1186
Range on HMM: 93-224/332.0
HRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKItdgKSILNKKI-YQRTLEVvdSTGKlATRTVMHYQY
...|.|  . ..  . || |. .     ||.| ...|. . | | | | .  | .| | ....    |. ....|   | ||.  | |   |  |.||..
rkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver...kefvkrniletrllel..skGn.ethrvlhykv

AGWTARGVPKSHaEMFDLMEMLKKSEKPIVVQCPNGIGR
 |||   .|| . ... | ...|.   . ...  . . .
fGwtettlpkye.dflalrkvmkevGvlllivmksalls
subfamily_CG42327_pd Subfamily CG42327 1031-1166 1.2e-11 38.8 In-house 53-187 (319) alignment 
Range on Protein: 1031-1166
Range on HMM: 53-187/319.0
NGQRVPIHANWVPTPGHPH-RFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIPPHISEPFKIGRFNIKITDGKSILNKKIYQRTLe
. .   ..|..|  .   .  .| .| .|...  ||| .. .     || | .  |. | .|  |.|.. . . .    .|..|  .   ... .  || 
ddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistl.

VVDSTGKLATRTVMHYQYaGWTARGVPKSHAEMFDLM
..    |  .| . || |  |   .|| ..| .. ..
llkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1007-1230 2e-09 31.5 In-house 45-269 (303) alignment 
Range on Protein: 1007-1230
Range on HMM: 45-269/303.0
YLPKNKHRYPTLPCKPSTAVKVIvngQRVPIHANWVPTPGHpHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIpPHISEPFKIG
    .| |.  . |   . ||.    .   |||...    . .. |.|| ||  |  ||| |. .  |  ...|  . |   .  |. . |.  . .|. 
vknmdknrfvdvicldhskvkls...dssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvf.prnqdflkfe

RFNIKITDGKSILNKKIYQrtLEVVD-STGKLATRTVMHyQYAGWTARGVPKS-----HAEMFDLMEMLKKS--EKPIVVQCPNGIGRSMAFIGTECLAR
   |.. . | .   . ..  | |.  | |.  .   .| .|  |    .|         ....|  .|.|    .| |     | ||. .|   |    
ersirvgefkrvelgdgwv..lkvlsvsngdyksflhvh.hykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

QV-EADPTIELTEALKHMREHRWNGIQKNFQLY
 . . .....|   |. .|. |   .|.  |. 
slhseqasldlvkclenvrngrlhavqnlsqfs
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1041-1096 2.2e-09 31.5 In-house 104-151 (350) alignment 
Range on Protein: 1041-1096
Range on HMM: 104-151/350.0
WvptpghphRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENLIVKCDYYIP
.        ..| ||.||..|  ||. .... .|. |..| ...|. . ||. | .
f........kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWq
DUF1510 Protein of unknown function (DUF1510) 848-963 8.1e-09 24.4 Pfam-A 16-126 (217) alignment 
Range on Protein: 848-963
Range on HMM: 16-126/217.0
LSVVIPVVLILVALVIGgIVFIWYRKREEKRKEeEAEEERKREEekliaERKRIEEVEEQRKREAEDKEKIEQLNAKVREKEERSEAR--RKQKEKDDEE
| . | .|..|...| .  ....  | ... .. | |||.. .|     |.. .|||.|..| .|.|..| .. ...  ..|...|..  ...||...||
LniaiaiVvvlivivaa.qllvgnskskkasad.eeeeeksede.....ekteeeevkeeekeaakdedkeddsesekkdeeseeeeeeekekkeeesee

EKRLYEEKEKEQRKKQIK
...  ||||... .|.| 
deketeekeesnvekeit
IncA IncA protein 829-947 8.4e-09 25.0 Pfam-A 21-150 (191) alignment 
Range on Protein: 829-947
Range on HMM: 21-150/191.0
VGVTAAVVGSSTVSTVSdelSVVIPVVL--ILVALVIGGIVFIWYRKREEKRKE------------EEAEEERKREEEKLIAERKRIEEVEEQRKREAED
.|... |...|. . .    |. . .||  . |.|...|. .. .....  ...             |.|.. .. ||.|.....|..| |.. . . ||
sGiallvlfasslgvli...sallgivliAlgvvLlalgllllllkapvqseedekieesrlqeelsesesqlseleeeleqleerlaeleseledleed

KEKIEQLNAKVREKEERSEARRKQKEKDDEEEK
.|...... ...|. |  | . |...|. .|  
lellqeelksleerlesleesikelakeirelr
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1137-1229 1.3e-07 25.4 In-house 86-183 (440) alignment 
Range on Protein: 1137-1229
Range on HMM: 86-183/440.0
LATRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKS-----EKPIVVQCPNGIGRSMAFIGTECLARQVEADPTIELTEALKHMREHRWNGIQKNFQL
. .||. .|.| ||  .||||  . .. ... ...|     . |..|.|  | ||.   |  ... |...    |..   .. ||. | . .|   | 
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1036-1156 6.8e-07 23.1 In-house 124-237 (244) alignment 
Range on Protein: 1036-1156
Range on HMM: 124-237/244.0
PIHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENlivkcDYYIPPhiSEPFKIGRFNIKITDGKSILNKKIYQRTLEVvDSTG
 | | .|   |    .|.|| || .|  ||| |. .  |. .|.||   |.     | | |   |||..    .| .|       |.|    ||. .|  
yinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpd..seplewyeeditvtltdrdefknikasnlei.esdm

KLATRTVMHYQYAGWTARGV-P
. . ...  .| . | . |  |
neshqaltmfqisnwpsdgttp
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1037-1154 1.7e-06 22.4 In-house 16-125 (130) alignment 
Range on Protein: 1037-1154
Range on HMM: 16-125/130.0
IHANWVPTPGHPHRFIVTQGPLKNTRYDFWMMLTQYDVEHIVMLGQNMENlivkcDYYIPPhiSEPFKIGRFNIKITDGKSILNKKIYQRTLEVVDSTGK
|.|..|   |.   .. || || .|  ||| |. .  |. .|.||   |.     | | |   |||..    .| .|  .    |.|    ||. .   .
inasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd..sePlewyeediivtltdrdefknikasnleiesdlne

lATRTVMHYQYAGWTARG
 . ...  .| . | . |
.shqaltmfqisnwpsdg
SKG6 Transmembrane alpha-helix domain 849-874 2e-06 17.2 Pfam-A 16-39 (40) alignment 
Range on Protein: 849-874
Range on HMM: 16-39/40.0
SVVIPVVLIlvALVIGGIVFIWYRKR
.|||||. |  |||.. . ...||..
gVviPVgvI..alvLlvfLilvyRRk
PTPc_motif_SM00404 1139-1228 5.1e-06 21.4 In-house 46-129 (140) alignment 
Range on Protein: 1139-1228
Range on HMM: 46-129/140.0
TRTVMHYQYAGWTARGVPKSHAEMFDLMEMLKKSEKPIVVQCPNGIGRSMAFIGTECLARQveadpTIELTEALKHMREHRwNGIQKNFQ
 .......    .   . |   .. | .|  .|... ..| |  |. || ..|  ... ..      ..| ||.. ..| | . |..|..
gfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryr.....qlslaeayefvkerR.piispnln
VIT1 VIT family 830-938 5.8e-06 12.3 Pfam-A 15-119 (213) alignment 
Range on Protein: 830-938
Range on HMM: 15-119/213.0
GVTAAVVGSSTVSTvsDELSVVIPVVLILVALVIGGIVFIWYRKREEKRKEEEA-EEERKREEEKLIAERKRIEEVEEQRkreAEDKEKIEQLNAKVREK
 ..|.|.| . .|.  .   |..  .  |||  |   .  .   . |. .||.  |.|... |... .|.. .... ...     ..|...|.......|
stfalvaGlagasa..ssklvllaGlaglvAgaiSmalGeylsvkaerdleeaelereqqeverspegeveeladilkak...glseetaaqvaeeltak

EERSEARRKQ
|.. ..  |.
edaldfllke