Gene ZK354.8 in Caenorhabditis elegans

Synonym: CELE_ZK354.8, CELE_ZK354.8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf8
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP234_AA protein Get Run
CeleP234_AA_183-454 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 181-470 3.4e-158 520.1 In-house 1-288 (288) alignment 
Range on Protein: 181-470
Range on HMM: 1-288/288.0
KRTEVICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWK
|..|||..|||||||..|.|||||||||||||..||..||..||||.||.|.|.||||||||.|||.|||.||.|||....||.||.||||||||||.||
kkkevinawirlvlqiaveglkkeyrdspneasidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWk

MIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTLVMSTMRISKPGDNAVvkIVKHIHWRNWPDHGVPDNFLSPFRLLT
|......|||||||||.||||.||||||||..|....|||||||.|..|.||||....|..||||.|...|  |||..|...|.|.|||.|.|||.|||.
mllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekv..ivkilhlleWdddgvPenylsplrlle

VVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDFAKFAK
|.|...||||||.||||||||||.||||.|||..|.||.|...||||||||||.|.||||||||.||||||.|.||||...||||.|.|.
vlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlredfvklae
0036941 (Phosphotyrosine protein) phosphatases II 196-465 1.2e-79 263.1 In-house 10-289 (297) alignment 
Range on Protein: 196-465
Range on HMM: 10-289/297.0
NGVAGLKKEYRDSPNEAP--EDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVML
.. |.|.||... ..  .  .  ......| ..|||..|...| |||||.|... ||.|..|.    .|.||.||.||..|.|.||.|.   ... ||||
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

CELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTLVMSTMRISKPGDNaVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN------CTK
.||||.|..| |.|.|. .|.. . |..   ...  |..... .. |..... |..  ...|.|.|. .|||||||... | ....  |..        .
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

PIVVHCSAGVGRTGTLALILIILESIC---LPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDF
|..|||||||||.||.... ..|. ..       . .. .. |||| |. ||||..||.. ....||.|  |... .  ..
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
0050432 (Phosphotyrosine protein) phosphatases II 196-457 3e-78 258.6 In-house 39-303 (308) alignment 
Range on Protein: 196-457
Range on HMM: 39-303/308.0
NGVAGLKKEYRDSPNEAP--EDIATSFLGNPTRNRYRNIPCCDITRVKLtDDPHFYIHANLVSSG--PNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIV
..  .|..|... ..  |  |  ....  | ..|||..|...| .|||| |... ||.|..|.     .||.||.||.||..|.| ||.|.   ....||
ldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIv

MLCELVEKGKPKSAEYFPSQIG-QTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAVvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC--TKP
||..|||.|..| |.|.|. .| .....|...  ...  |  ... .. |..... ||. . ..|.|.|. ||||||||... . ...|  |...   .|
mLtklvengrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdges.rtvthfhytnWpdhgvPpspeilldflelvrkslpggp

IVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
||||||||||||||.......|| .     . |. ...|||| |  .|||..|||. .|..|||| ||.
ivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0040438 (Phosphotyrosine protein) phosphatases II 186-459 1.4e-76 253.1 In-house 5-280 (317) alignment 
Range on Protein: 186-459
Range on HMM: 5-280/317.0
ICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIA-TSFLGNPTRNRYRNIPCCDITRVKLTDDP----HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWK
.. .. ..|.... .|..|..| ..  ....  .... |. .|||..|...| .||||....    . ||.|..|.    .|.||.||.||..|.| ||.
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

MIIVTGIEYIVMLCELVEKGKPKSAEYFPSqiGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPgDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLT
|.   |...||||.||.|.|..|.|.|.|.  |.|...|...  ...  .  ..  .. |.....  ..  . .|.|.|. .|||||||... . ...| 
mvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfle

VVKNC----TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLalKKYV
 |...     .|..||||||||||||.......|| .    .. |.  ...||| |  ||||..|| . ....||||  |...
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl..krkl
0051299 (Phosphotyrosine protein) phosphatases II 185-453 2.3e-75 249.0 In-house 9-286 (288) alignment 
Range on Protein: 185-453
Range on HMM: 9-286/288.0
VICSWIRLVLQNGVAGLKKEYRDSPNEAPE--DIATSFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEF
 ...... .|.||..||..|... ..  |     |...  | ..|||..|...| .||||..    ... ||.|....  ...|.||.||.||..|.|.|
ellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedF

WKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqiGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPG---DNAVVKIVKHIHWRNWPDHGVPDNFLSP
|.|.   ....||||..|||.|. |.| |.|.  |.....|...  ...  |  ... .. |..... .    .  ...|.|.|. |||||||||.. . 
WrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspell

FRLLTVVKNC----TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
...|  |...     .|.|||||||||||||.......|| .     . |......||| |. .|||..||.. ....||||
ldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 196-453 6.7e-74 244.1 In-house 9-272 (273) alignment 
Range on Protein: 196-453
Range on HMM: 9-272/273.0
NGVAGLKKEYRDSPNEAPED--IATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVML
.|...|..|... ..  |.    ....  | ..|||..|...| .||||.|... ||.|..|.  . .|.||.||.||..|.|.||.|.   ....||||
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL

CELVEKGKPKSAEYFPSQIGQ-TTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAvVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN------CT
.||||.|..| | |.|.  |. ... |...  ...  .  ... .. |..... |..  ...|.|.|. .|||||||... | .... .|..        
telvelgrekcaqYwpleggelsltygkftvtllseet..kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsn

KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
.|.|||||||||||||.......|. .     . |. ....||. |. .|||. ||.. ....||||
gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 182-453 1.1e-73 244.0 In-house 10-304 (307) alignment 
Range on Protein: 182-453
Range on HMM: 10-304/307.0
RTEVICSWIRLVLQNGVAGLKKEYRDSPNEAP----EDIATSFLGNPTRNRYRNIPCCDITRVKLTD-----DPHFYIHANLV--------SSGPNPRRF
..........| |.....||.||... ... .    |  ..... | ..|||..|...| |||||..     ... ||.|. |        ..  ..|.|
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf

ICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQiGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWP
|.||.||..|.|.||.|.   |...||||.||||.|..| |.|.|.  |..  .|...  ...  .  .. ... |....  . .  . .|.|.|. .||
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwp

DHGVPDNFLSPFRLLTVVKN------CTKPIVVHCSAGVGRTGTLALILIILESICLPDF---IGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|||||..| . ....  |..      . .|..||||||||||||.......|. .        . ..  ...||| |  |||.. || . ....||.|
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0046845 (Phosphotyrosine protein) phosphatases II 201-457 2.3e-73 242.4 In-house 2-278 (284) alignment 
Range on Protein: 201-457
Range on HMM: 2-278/284.0
LKKEYRDSPNEAPE----DIATSFLGNPTRNRYRNIPCCDITRVKLTD-----DPHFYIHANLVSSG-----PNPRRFICTQAPLNGTIEEFWKMIIVTG
|..|..  ..  .       .. .. | ..|||..|.. | .||||.      . . ||.|..|.        ....||.||.||..|.|.||.|.   .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

IEYIVMLCELVEKGKPKSAEYFPSQiGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC-
...||||.||||.|. | | |.|.  |.. ..|...  ...  |  ... .. |..... | .  ...|.|.|. .|||||||... . ...|  |... 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

-----TKPIVVHCSAGVGRTGTLALILIILESICLPD---FIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
      .|||||||||||||||.... ..|| .   .    . |. ....||| |. .|||..||.. ....|||| ||.
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0039614 (Phosphotyrosine protein) phosphatases II 180-456 1.1e-72 240.3 In-house 13-292 (297) alignment 
Range on Protein: 180-456
Range on HMM: 13-292/297.0
KKRTEVICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHF-----YIHANLVSSGPN-PRRFICTQAPLNG
 ....|.  ...|  .|.  .|..|. . ..  |.   . .  | ..|||..|...| .||||.. ...     ||.|..|.     .|.||.||.||..
piplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe

TIEEFWKMIIVTGIEYIVMLCELVEKGKpKSAEYFPSQIGqttKIGRLCTVTKESRVdiDKTLVMSTMRISKpgdNAVVKIVKHIHWRNWPDHGVPDNFL
|.| ||.|.   |...||||..|||.|. | |.|.|.  |   . |...  ...  .  ..  .. |.....   |  ...|.|... .|||||||... 
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn...ngesrtvthfqytgwpdhgvppsle

SPFRLLTVVKN------CTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALK
. ...|  |..        .|..||||||||||||.......|| .     . |.  ...||| |  ||||. || . ....||.|  |
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
DSPc_SM00195 204-453 3.1e-71 235.1 In-house 5-262 (263) alignment 
Range on Protein: 204-453
Range on HMM: 5-262/263.0
EYRDSPNEAP--EDIATSFLGNPTRNRYRNIPCCDITRVKLTDDP----HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELV
|.... ....  |   . .  | ..|||.||...| |||||....    . ||.|| ..   .....|.||.||. |.|.||.|.. .....||||.| .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGKPKSAEYFPSQIGQTTKIGrLCTVTKESRVDIDKTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTK----PIVVHC
|.|| | ..|.|...|.....|   .|.  .    .. ... |....| |.    . |......|||||||||.  | ..|| .||....    ||||||
engkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC

SAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|||||||||...| |||....  . . .  .. .||..|...|||..|||......|||.
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 204-453 3.1e-71 235.1 In-house 5-262 (263) alignment 
Range on Protein: 204-453
Range on HMM: 5-262/263.0
EYRDSPNEAP--EDIATSFLGNPTRNRYRNIPCCDITRVKLTDDP----HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELV
|.... ....  |   . .  | ..|||.||...| |||||....    . ||.|| ..   .....|.||.||. |.|.||.|.. .....||||.| .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGKPKSAEYFPSQIGQTTKIGrLCTVTKESRVDIDKTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTK----PIVVHC
|.|| | ..|.|...|.....|   .|.  .    .. ... |....| |.    . |......|||||||||.  | ..|| .||....    ||||||
engkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhC

SAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|||||||||...| |||....  . . .  .. .||..|...|||..|||......|||.
saGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 190-453 9.9e-70 230.5 In-house 11-277 (278) alignment 
Range on Protein: 190-453
Range on HMM: 11-277/278.0
IRLVLQNGVAGLKKEYRDSPNEAPEDIA-TSFLGNPTRNRYRNIPCCDITRVKLTDDP----HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIV
.. .| |. ..|..|. . ..  ....  . .. | ..|||..|...| .||||....    . ||.|..|.  . ||.||.||.||..|.| ||.|.  
llelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwe

TGIEYIVMLCELVEKGKPKSAEYFPsqiGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAVvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN
 |.. ||||.||||.|..|.|.|.|   |.....|..   ...  .  ... .. |..... ||. . ..| |.|. .|||||||... . ...| .|..
lgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavre

----CTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
    . .|..||||||||||||.......|| .    .. ..  ...||| |. ||||..|| . ....||||
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 223-451 2e-68 225.7 Pfam-A 1-235 (235) alignment 
Range on Protein: 223-451
Range on HMM: 1-235/235.0
NPTRNRYRNIPCCDITRVKL--TDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGR
| ..|||..|...| |||||  ...|. ||.|| |.. .....||.||.||. |||.||.|..   ...||||..|.|||. | |.|.|.. ..... |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LCTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT----KPIVVHCSAGVGRTGTLALILIILESICLP
..  .||.  ...|  ........| ...   ..||..|. ||||||||..  | ..|.. |.. .    .|.|||||||||||||.... |.||..   
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

DFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
. . |  .. .||..|. .||.. || . ....||
eevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 223-451 2e-68 225.7 In-house 1-235 (235) alignment 
Range on Protein: 223-451
Range on HMM: 1-235/235.0
NPTRNRYRNIPCCDITRVKL--TDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGR
| ..|||..|...| |||||  ...|. ||.|| |.. .....||.||.||. |||.||.|..   ...||||..|.|||. | |.|.|.. ..... |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

LCTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT----KPIVVHCSAGVGRTGTLALILIILESICLP
..  .||.  ...|  ........| ...   ..||..|. ||||||||..  | ..|.. |.. .    .|.|||||||||||||.... |.||..   
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

DFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
. . |  .. .||..|. .||.. || . ....||
eevdvlqivkelRkqRpgmvqsleqYiflykaile
0040439 (Phosphotyrosine protein) phosphatases II 218-453 2.6e-65 215.8 In-house 6-246 (249) alignment 
Range on Protein: 218-453
Range on HMM: 6-246/249.0
TSFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqiG
.... |. .|||..|...| .||||..     .. ||.|....    .||||.||.||..|.| ||.|.   ||..||||..|||.|. | |.|.|.  |
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..g

QTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPgDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN------CTKPIVVHCSAGVGRTGTLALIL
.....|..   ...  |   . ... |.....   .  .  |.||.. .|||||||..| . ....  |..      . .|..||||||||||||.....
gsleygdftvtllsvev..kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

IILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
..|| .     . ..  ...||. |. |||.. || . ....||.|
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 219-453 6e-64 211.1 In-house 5-243 (245) alignment 
Range on Protein: 219-453
Range on HMM: 5-243/245.0
SFLGNPTRNRYRNIPCCDITRVKLTDDP----HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqiGQ
... |...|||..|...| |||||..|.    . ||.|..|.    ...||.||.||..|.| ||.|.   ||..||||.|..|.|..|.|.|.|.  |.
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

TTKIGRLCTVTKESRVdiDKTLVMSTMRISKPgDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN-----CTKPIVVHCSAGVGRTGTLALILII
....|...  ...  .  ...... |.....   .  .. | |.|. .||||||||.  . ...|  |..       .|..||||||||||||.......
sltygdftvtllseeh..lddytvrtlevtnl.gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

LESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|| .     . ..  ...||. |  ||||. || . ....||.|
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 218-455 8.7e-64 210.9 In-house 28-274 (278) alignment 
Range on Protein: 218-455
Range on HMM: 28-274/278.0
TSFLGNPTRNRYRNIPCCDITRVKltdDphfYIHANLVSSGpnPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqiGQTTK
  .|||  .|||..|...| .|||   |   ||.|.....   |..||.||.||. |.. ||.|.   ||..||||.||||.|. | |.|.|.  |..  
alylgnldknRykdilpydhsrVk...d...YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggslt

IGRLCTVTKESRVDidKTLVMSTMRISKP---GDNAVVKIVKHIHWRNWPDHGVPDNF--LSPFRLLTVVKN-----------------CTKPIVVHCSA
.|...  ...  |   .. .. |...        .     |.|.|. .|||||||..    | ..||  ...                   .|..|||||
ygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GVGRTGTLALILIILESIclPDFIGVPRLLAKLREERFR-AVQTEMQYLYAHRCVLEYLAL
||||||||... ..|| .  .. . ..  ...||. |   |||...|| . ....||.|  
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 185-476 1.2e-63 210.0 In-house 2-298 (307) alignment 
Range on Protein: 185-476
Range on HMM: 2-298/307.0
VICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIAT-SFLGNPTRNRYRNIPCCDITRVKLTDDP--HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKM
|.  |..  |. ||  |. |.|   . .|| ... .|  |. .|||....| | .|. .. |     ||||| .    .|..|||.| ||. |. .|| |
vvkpwvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwam

IIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLC---TVTKE--SRVDIDKT-LVMSTMRISKPGDnavVKIVKHIHWRNWPDHGVPDNFLSP
.|   .| ..|||...| .| |  .|.| . ||.   |      .|..    ..  |.  . ..|...   ..    . ..|. | ||||.|||.  |. 
aiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqk...srtiqhlqwenwpdrgvpqinlta

FRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESIC-LPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLaLKKYVQSREDFAkFAKDYEQ
  ||  |.  | |.||||||||||.||.  | .. . .    .   . .|. .||..|  |.|||.|||| || .|||. |..| .. |..  ..|.||.
inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf.lelyketyeell.ltknyee

AL
  
ky
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 184-459 3.3e-61 201.6 In-house 9-294 (305) alignment 
Range on Protein: 184-459
Range on HMM: 9-294/305.0
EVICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIATS-FLG------NPTRNRYRNIPCCDITRVKLTD-DPHFYIHANLVSSGPNP-RRFICTQAPLNGT
 ..  ...  |. ||  |..|.|.  . .  |..   |        . |.|||...|| | . ||| .  |  ||||| |     | .||||.| ||. |
piveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqt

IEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKE---SRVDIDKTLVMSTMRISKPGDNAVVkiVKHIHWRNWPDHGVPDN
|.||| |.|   .| |||||  || || | |.|.|   |.  ..   . | .      .. |  . .......  ||. .   |.|..| .||| |||  
idefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkms..vrhlqwtewpdrgvppc

FLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPD-FIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLaLKKYV
 |. . ||. ..    |||||||||.|||||.  |  ||| |.       .| |.  ||..|  ..|...|||. || .|.|. |.|| 
kltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf.lekyk
0037934 (Phosphotyrosine protein) phosphatases II 219-453 2.4e-60 199.4 In-house 6-242 (243) alignment 
Range on Protein: 219-453
Range on HMM: 6-242/243.0
SFLGNPTRNRYRNIPCCDITRVKLtDDpHFYIHANLVSSGPnprRFICTQAPLNGTIEE----FWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPsqiGQ
... | ..|||..|...| .|||| .. . ||.|||.   |   |.|.||.||..|.|.    ||.|.   ||..||||.||||.|. | |.|.|   |.
llpenlsknrysdilpydhsrvkl.eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...ge

TtKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVK------------NCTKPIVVHCSAGVGRTGT
.  .|...  ......   .  .. |.... .. . ... | |.|. .||||||||.. .  ..|  |.            .  .|..||||||||||||
v.tygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

LALILIILESIclpDfIGVPRLLAKLREERFR-AVQTEMQYLYAHRCVLEYL
|......|. .   . ...   ...||| |.  ||||. || . ....||.|
liaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPRD_pd Subfamily PTPRD 194-458 1.4e-59 197.2 In-house 18-286 (564) alignment 
Range on Protein: 194-458
Range on HMM: 18-286/564.0
LQNGVAGLKKEYRDSPNEAPEDIATS-FLGNPTRNRYRNIPCCDITRVKLT----DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIE
 .|. . ...||..  ..  . . ..    |  .||| ||   | .||.|.    |.   || |. . .  ... .| ||.||. |||.||.|.    ..
kansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnss

YIVMLCELVEKGKPKSAEYFPSQiGqTTKIGRLcTVTKESRVDIDkTLVMSTMRIsKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC---
 |||| .|.|||| | ..|.|.. | |...|.| ||| |. ...  . .. |... |  ..  .. |.. |. .|||||||..  |  .|.. |...   
tiVmltkleEkgkvkchkYWPek.g.tetygel.tVtleeeeela.dyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnep

-TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKY
 ..|||||||||||||||   | ..|| |   . . .   ...||..|   |||| || . |. .||.||  . 
dagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 179-461 2.2e-59 195.7 In-house 2-295 (305) alignment 
Range on Protein: 179-461
Range on HMM: 2-295/305.0
KKKRTEVICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIATSFL--GNPTRNRYRNIPCCDITRVKLTD-DPHFYIHANLVSSGPNPRRFICTQAPLNGTI
||..   |  ... .|..| |||..|.         .   .|    .  .|||... | |  ||||    || ||||| ||.  ||.|||||||||. | 
kkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektc

EEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTK---IGRLCTVTKESRVDID----KTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGV
 .|| | .   .|.| |||.|.|||  | .|||.|. ... .    |.  .|  || | ..       ...   .   |  . .. |.| || .||| ||
adfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgv

PDNFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIG-VPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQS
|   |. . ||.  .    |||||||||.||||.. ..  ||. .   . |    ..| |.||.|  ..||. |||. |. .|.|.  || .. 
paadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkllde
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 181-474 2.8e-59 195.4 In-house 1-298 (312) alignment 
Range on Protein: 181-474
Range on HMM: 1-298/312.0
KRTEVICSWIRLVLQNGVAGLKKEYRDSPNEAPEDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWK
.|.|.|  |   |.      | |||.   |  ..   |.||     ||| || | |  |  |. |  ||||||.|    .| ||.|||.||. |.  ||.
qraemikkwasavmmstpqqltkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwq

MIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRlcTVTKESRVDID---KTLVMSTMRISKPGDNAVVK--IVKHIHWRNWPDHGVPDNFLSP
. .  |   |..|| .|| |  |.|.|    .|          |  |.  .|.   |.    | |. |   .|  .   ..|  |  |||||.||   . 
lalslgstsiillcgfvedgsekcakyisdivgfvdledh..rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdta

FRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK-YVQSREDFAKFAKDYEQ
.|||. ||.  ||.. |||||||||||||||  .. ..  |    |   .  || .| |.|..  ||.|| |||||.|  |  | .. ....|| . | .
lrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfketyak
subfamily_PTPRB_pd Subfamily PTPRB 221-456 7.8e-57 187.5 In-house 49-288 (293) alignment 
Range on Protein: 221-456
Range on HMM: 49-288/293.0
LGNPTRNRYRNIPCCDITRVKL----TDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIgQTT
  | ..|||.||   | .||||    ...   || || ..    || || || || .|...||.|.  .  . |||| .|||||| |  ||.|..  ...
avnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epv

KIGRLcTVTKESRVDIDkTLVMSTMRISKpgdNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT------KPIVVHCSAGVGRTGTLALILIIL
  | . .||  .  . .   |. ...|.|   .   . |.. |.  |||||||..  .  ...  |.. .      .|||||||||||||||.  .  .|
lyGdi.kvtlvaeeele.dwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrll

ESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALK
..|   |.. .  ..|.|||||.  |||| ||.. |.|||..|  |
qaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 184-459 1.3e-54 179.8 In-house 12-289 (290) alignment 
Range on Protein: 184-459
Range on HMM: 12-289/290.0
EVICSWIRLVLQNGVAGLKKEYRDSPNEA-PE-DIA-TSFLGNP--TRNRYRNIPCCDITRVKLTDD-PHFYIHANLVSsGPNPrRFICTQAPLNGTIEE
|..  .   | . .| .| ||| .      |   .    |  |.  ..|||....| |.||| | |  .  |.||| |  | ..  || || .|. |. .
eafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk.Glka.mfiltqGalkdtvid

FWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLcTVTKESRVDIDKTLVMSTMRISKpGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFR
.|.|.. ... .|||||||.|.||.| ..|.| . |..  .| . ||.     | |. ... |. . .  |.   ...||.. . |||. |.   |. .|
iwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGei.tvlcseeddkdaniikktlsvrd.kdsGkehklkhlkikswpdksvalstlallr

LLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYV
.| .... . |.|||||||.|||||.. | . |. .     . .  |   ||. |  .|| ..|||   . .|..    ||.
tlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfkyi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 196-451 1.1e-52 173.9 In-house 18-277 (288) alignment 
Range on Protein: 196-451
Range on HMM: 18-277/288.0
NGVAGLKKEYRDSP--NEAPEDIATSFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEY
.. .|...||.  .  ..  .. |..   | ..||||||   | .||||..    .   || |. . .  . ...|.||.||  |...||...  . .. 
rnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

IVMLCELVEKGKPKSAEYFPSQiGQTTKIGRLcTVTKESRVDIDKTlVMSTMRISKPGDNavvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC----
|||| ||||.|| |  ||.|.. .. .. | . |||  .  . ... |. .. . | ...     ... ..  |||||||..    . ||. ||.     
ivmltelveggktkCeeYWPda.dkpknyGsv.tvtlveskeledf.vlrklllekkkte...leitqyqylaWpdhgvPeskapllellrqvkvanqad

TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
|.||.||||||||||||   .  ... .   |.| |   .||||..|.  |||. || . ....|.
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPN12_pd Subfamily PTPN12 223-454 1.5e-52 173.3 In-house 40-278 (290) alignment 
Range on Protein: 223-454
Range on HMM: 40-278/290.0
NPTRNRYRNIPCCDITRVKLTDD----PHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKI
| ..|||..|   | .||.|. .       || ||..  . .. ..| .|.||  |...||.||. . .| .||.|..|| || | . |.|.. ......
nvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelef

GRLCtVTKESRVDIDKTLVMSTMRISKPgdnAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT----KPIVVHCSAGVGRTGTLALILII---LE
| .. ||.|.   .|. ... |... .       ..|. .|...||||||| .. | ..|.. |..      .|.|||||||||||||.  | ..   |.
gefe.vtleeekavdddflirtLkveaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellk

SICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
.  .|. . |  |...||..|  .|||. || . ...|.|.. 
aekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 189-463 9.5e-51 167.7 In-house 10-291 (318) alignment 
Range on Protein: 189-463
Range on HMM: 10-291/318.0
WIRLVLQNGVAGLKKEYRDS-PNEAPEDIATS-FLGNPTRNRYRNIPCCDITRVKLTDDPH----FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMI
 .| . ..|   |..||    ..|.      |    | ..||| ||   | |||||..        || || .    . . .| .||||  |||.||.|.
hvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmv

IVTGIEYIVMLCELVEKGKPKSAEYFPSQigQTTKIGRLcTVTKESRVDIDKtLVMSTMRISKPGDNAvVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVV
   .   |||| ...|.|| | . |.||.  .....|.| .|. ...|.... .|. ...... . .. ...|.  |. .|||.|||..  |   |.  |
WeqnsavivmltqeeergkakvhryWPsk..gsrsygkl.vvelkeevelsd.yvlrefkvtrteeee.srqvrqyhytsWpdegvpesgaslldlvrqv

KNCT-----KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAL-KKYVQSRE
..       .||||||||||||||.   . |.|| |     . |     .|||.|   |||| || . .  .||.||  ...|....
skaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasd
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 194-456 2e-50 166.7 In-house 18-286 (319) alignment 
Range on Protein: 194-456
Range on HMM: 18-286/319.0
LQNGVAGLKKEYRDSPNEAPEDIATS-FLGNPTRNRYRNIPCCDITRVKLTDDPH----FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIE
 ..|  .|.||...  .  .... ..    | ..|||.||  .| |||.|.. .      || |. . .  . ..|| |||||. |||.||.|.   .. 
astgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

YIVMLCELVEKGKPKSAEYFPSQigQTTKIGRLcTVTKESRVDIDkTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT--
 .|||..||||.| |  .|.|..  . .. ||| .|| |..   .  .... . . |  ..   . ||| .. .||||.||.. .|   ||  ... .  
ivvmltklveklkvklkkywpee..nfeeyGrl.ivtleeeeele.dyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek

---KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALK
   .|||||||||||||||   . ..|| . .   . |     .||  |   ||.. || . .  .||..   
tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 200-454 1.5e-49 163.9 In-house 28-291 (298) alignment 
Range on Protein: 200-454
Range on HMM: 28-291/298.0
GLKKEYRDSPNEAP-----EDIATSFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYI
|...|..   .        |  ...   |  .||| .|   | .|| |..    .   || |  ...  .   || |||||. |.|.||.|..   |. |
gyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigti

VMLCELVEKGKPKSAEYFPSQigQTTKIGRLcTVTKESRVDiDKTLVMSTMRISKPGDNaVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN----CT
||| .|.|..| |  .|.|..  .... |.. ||.  |. .    |.. .. .||   .   . |...|. .|||.||| |  | . ||. |.     . 
VmltnleeldktkyhkywPde..gketygei.tvsllskee.fadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqag

-KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
 ||..|.|||||||.||   |  .|| .     . | . .  ||..|  ||||| || . .  |||.|.
nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 225-444 7.5e-49 161.1 In-house 52-272 (301) alignment 
Range on Protein: 225-444
Range on HMM: 52-272/301.0
TRNRYRNIPCCDITRVKLTDDP-HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCT
 ..|| ..||   | |.. .|     |||| ...  .|.|||.||.||. | |.|| |..   .| ||||.. ||| . | .||.|..|... .|||   
dkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfki

VTKESRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPR
 .|.. . ..| ..  |...    ..   . | |  . .|.|.|||      | |. .||.  ||||||||||.||. ..    ..   .     | . .
kiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptielte

LLAKLREERFRAVQTEMQYLY
 |..|||.|...|||. |  .
alkhlrehrwngvqtnsqlyw
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 194-455 7.9e-48 158.0 In-house 10-278 (281) alignment 
Range on Protein: 194-455
Range on HMM: 10-278/281.0
LQNGVAGLKKEYRDSPNEAPE--DIATSFLGNPTRNRYRNIPCCDITRVKLTDDPH----FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGI
 ||  ||...||..  .   .    |.    | ..|||.||   | ||||.|.. .     || || |..  .....| ||.|.  ....||.|.. . .
sqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkv

EYIVMLCELVEKGKPKSAEYFPSQIgQTTKIGRLcTVTKESRVdIDKTLVMSTMRISKPGDNAvvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVV-----
. |||. . .|.|| |   |.| .  ...|.| . ||.....    .| .  ...... . ..  . |..... .|||||||..    .   . |     
saivmvtreieagklkChrYWPddn.selkygdv.tvkstaee.ekatyierkfkleresget..reveqlaytaWPdhGvPattkellefrkevlklte

KNCTKPIVVHCSAGVGRTGTLALILIILESICL-PDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAL
|.   |.|.|||||||||||   .  .....      . |  ..|.||.||   ||| .|| . .. ||..|  
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN13_pd Subfamily PTPN13 223-454 1.3e-47 157.3 In-house 37-270 (273) alignment 
Range on Protein: 223-454
Range on HMM: 37-270/273.0
NPTRNRYRNIPCCDITRVKLTDDPHfYIHANLVS--SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGR
| ..|||||.  .| ||||| |.   || |.|.    | .  ..| .| ||  |...||.|.     | |.|.   .|||| |   |.|.. ....|.  
nkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsn

LCTVTKESRVDIDkTLVMSTMRISKPGDNAVvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTK---PIVVHCSAGVGRTGTLALILIILESICLPD
  .|...  .. | ..|.... ...   ... . | |... .||||||| . ..  .... |..  .   |||||||||.||.|||  | ..|. |    
rlevellkvqkld.gfvvralavkdsesges.revahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdk

FIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
 . |  .. |||| |   |||. ||.. .. .|| | 
efdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 200-454 4e-47 155.9 In-house 23-284 (305) alignment 
Range on Protein: 200-454
Range on HMM: 23-284/305.0
GLKKEYRDSPNE-APEDIATSfLGNPTRNRYRNIPCCDITRVKLTDDPHF----YIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLC
||...|.  ..|  . |. ..   | ..||...|   |  |..|| ...     || |. | .  .  ..| .|.||. |...||..|. . .. ||||.
gleaqykslyeeeesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmlt

ELVEKGKPKSAEYFPSQIGQTTKIGRLcTVTKESRVDIdKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT-----KPI
.||| || |   |.| ........|.. .|. .|.  . . ...  ..||.  ..   . | . .  .|||||||.   |  .|.  |..       .|.
klveggkdkCrqYWpesktekkefgef.svelksekta.sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpl

VVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
.|||||||||||.   . | || .   . . | ..| .||..|  .|||  || . |  . |.. 
lVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPN23_pd Subfamily PTPN23 220-452 7.6e-46 151.2 In-house 40-279 (288) alignment 
Range on Protein: 220-452
Range on HMM: 40-279/288.0
FLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSS-GPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKI
   ....||.|.|   | .|||| .    || |  | .  |    ||.|||||..|. .||.|.     . |||| .  |.|||| ..|.|.. |.|.| 
aklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

GRLcTVTKESRVDIDkTLVMSTMRISKPGDNaVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN--------CTKPIVVHCSAGVGRTGTLALILIIL
| | .|| .|  . . | |  .....  . .  || |.|... .||..|||.   . ...| .|..        . .|.||||||||||||..||.  ..
gdl.svtlksvrete.thvervlkletldad.avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaav

ESIC-LPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEY
. .   .  . ..... .|||.|   ||.. |.  .   |||.
relekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPN3_pd Subfamily PTPN3 220-451 1e-45 150.9 In-house 38-273 (280) alignment 
Range on Protein: 220-451
Range on HMM: 38-273/280.0
FLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNP----RRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqIGQT
   | ..||||.|   |.|||||.. .  || || |.   .      |.| || ||. | ..||.|.    .. |||| .|||.|. |  .|.|.  ...
kpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tede

TKIGRLCtVTKESRvDIDKTLVMSTMRISKPGDNaVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT----KPIVVHCSAGVGRTGTLALILIILE
.. |..  |. |.. | .|. |.  . ...   .   . . .. . .||||||||.  . ..... |...     .|.|||||||.|||| | |. . | 
leygefs.vkceke.detksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletala

SICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
 |   . . .. .. ..|. |   |||. || .   ..|.
lieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 222-455 6.1e-45 148.4 In-house 8-244 (250) alignment 
Range on Protein: 222-455
Range on HMM: 8-244/250.0
GNPTRNRYRNIPCCDITRVKLTDD----PHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPkSAEYFPSQigQTTK
 |  .||| .|   | .|| |  .       || |  . .  . . || ||.||. |||.||.|..   .. |||| .|.|..|    .|.| .  ...|
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..kaek

IGRLcTVTKESRvDIDKTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC-----TKPIVVHCSAGVGRTGTLALILIILES
 | . ||.  |. ..   ... .. .||    |  .||...|. .||| |||..  . . ||. |.       ..|..|.|||||||.|.   |  .|| 
yGdv.tvsllsk.eefadytkrklklskakk.aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

ICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAL
.     . | ... .||..| .||... || . .. .|..|  
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0041856 (Phosphotyrosine protein) phosphatases II 223-459 1.2e-44 147.4 In-house 1-177 (182) alignment 
Range on Protein: 223-459
Range on HMM: 1-177/182.0
NPTRNRYRNIPCCDITRvkltddPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCelvekgkpkSAEYFPsqigqttkigrlc
| ..|||..|...| .|      .  ||.|||. ..  ..|||.||.||..|...|..|.   || .||.|.         .  |.|             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

tvtkesrvdidktlvmstmriskpgdNAVVKIVKHIHWRNWPDHGVPDnFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESiclpdFIGVP
                          . . . . .... .|||||||| . . ....  |..  .|..|||||||||||||... ....       ....
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

RLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYV
  .. .|. |. .|.|. || . ....||.| |||..
eavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 188-452 4.4e-44 145.3 In-house 16-289 (310) alignment 
Range on Protein: 188-452
Range on HMM: 16-289/310.0
SWIRLVLQNGVAGLKKEYRDSPNEAPE-DIATSFLGNPTRNRYRNIPCCDITRVKLTDDP---HFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMII
 .|    . |. || |.||    .        ..  .  .||| .. | | .||||. |    . ||||| | .      |||.| ||. || .||.||.
nfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmif

VTGIEYIVMLCELVEKGKPKSAEYFPSqIGQTTKIG--RLCTVTkESR-----VDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDN--FLS
    | |..||  .|.|.||.  |.|| .| |   |  |.  .. ||      ...  |.|   . . .   |     |. |.| |||| ||||.     
qeraesilllckvgeegrpkcvgywps.lgvtetygcirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv

PFRLLTVVKNCtkPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEY
| |||. |.    | |||||||..|..... . . .. .   . . .  . ..|. .|.  .|||.|||. .|  . .
pqrllaqvrhg..pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 200-457 4.6e-44 145.2 In-house 12-273 (281) alignment 
Range on Protein: 200-457
Range on HMM: 12-273/281.0
GLKKEYRDSPNEAPEDIATSFL--GNPTRNRYRNIPCCDITRVKLTD-----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVM
 .|.|. . | . | |..| |    |  .||| |||| ||.||.|       .   ||||| . |    | .| || | . |  .||.||       |||
dfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivm

LCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNavvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTKPIVVH
||...|  . | ||||| .     .. .|    ..| |  .|.|| . . .|  |.    ... |  |..|||  ||.     ...|  ..  . | |.|
lcqfletnrekcaeyfprnahcclqfdklsvsyedstv..nkslvttrlnlsyeget...rlithwlwkewpdwqvpessevmlkilrkirarstppvih

CSAGVGRTGTLALILIILESIC----LPDfigVPRLLAKLRE-ERFRAVQTEMQYLYAHRCVLEYLALKK
|||||||.|||  . | |.||     |||   . .....||   |  .|||  ||.   . .|..    |
csagvgrsgtlmaveialqsihshftlpd...ikqivshlrvtgraasvqtlqqymliwkvlldfgvayk
subfamily_PTPN9_pd Subfamily PTPN9 190-455 7.9e-44 144.9 In-house 7-292 (297) alignment 
Range on Protein: 190-455
Range on HMM: 7-292/297.0
IRLVLQNGVAGLKKEYRDSPNEAPEDIAT--SFLGNPTRNRYRNIPCCDITRVKLT----DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMII
.  | ..|  ||.||| .  ||..|  ..     .| ..||| .. | | |||.|.    |.   ||.|| |    ... || || ||. |...||.|. 
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvW

VTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVdiDKTLVMSTMRISKPGDNAvVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVK
   .  |||   .||.|. | ..|.|.. ..... | |   . | ..   .  ..... |..  ..   . | |     |||.|||..  | . .| .|.
eqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee..eedykvrvleiknvktee.srkvthfqflsWPdyGvPssaaslldvlekvr

NC-----------------TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAL
.                    |||||||||.|||||.. . | |. .   . . |   . .||. |  ..||. || . . .||||   
ekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_PTPN6_pd Subfamily PTPN6 223-459 9.4e-44 144.6 In-house 54-303 (306) alignment 
Range on Protein: 223-459
Range on HMM: 54-303/306.0
NPTRNRYRNIPCCDITRVKLTDDPH---FYIHANLVS---SGPNpRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTT
| ..|||.||   | |||.|...      || || ..    | . ...| ||  |. |...||.|.     . |||. . ||.|| | | |.|..  ...
nkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd.ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee

kIGRLcTVTKESRvDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN---C-----TKPIVVHCSAGVGRTGTLALILI
  |.. .||. |  .  .. .. ....||  ..   . | . |...||||||| .      .|. |..         . |||||||||.|||||. .| |
.yGki.svtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDi

ILESICLPD---FIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYV
.|. |        | . .|  ..|| |   |||| || . .. . .|.  || .
llkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkkl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 201-457 3.9e-43 142.3 In-house 20-280 (515) alignment 
Range on Protein: 201-457
Range on HMM: 20-280/515.0
LKKEYRD--SPNEAPEDIATSFLgNPTRNRYRNIPCCDITRVKL---TDDPHF-YIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLC
. .|..|   ||  |. .|   . | ..|||.||   | .||||    |.||  |. |  . |  | . .|..|.|.. ....||....   .  |.|. 
fseefhdlpgpniypqtvaqeei.nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

ELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKeSrVDIDKTLVMSTMRISKPGDnavVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN----CTKPIV
.| |  | | ..|.| . |.. | | .   .  | .. .   .  .... |  |   .. |   |. .|||.||| .  | ..|.  ||      | |..
klkegdkikcgkyWPdkpgdsvkfGsikvelv.s.leactggikrkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpli

VHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
.|||||||||| .  |  ..  .   . . | ... ..|..|   |||. || . .  |||.|  ..
ihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrn
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 219-454 6.6e-43 141.6 In-house 16-265 (270) alignment 
Range on Protein: 219-454
Range on HMM: 16-265/270.0
SFLGNPTRNRYRNIPCCDITRVKLT----DDPHFYIHANLVS-SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIG
..  ... |||..|     |||.|     |.   || || |     .....|....||. |...||.||. .  . |||. .|.|||. | . |.|.. .
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

QTTKIGRLCTVTKESRVDIDKTLVMSTMRISKPGDNavVKIVkHIHWRNWPDHGVPD---NFLSPFRLLTVVKNC---------TKPIVVHCSAGVGRTG
...|.      .  .    ..  ..  .|. . |..   ..| | .. .|||||||    . ||.  ||.....          ..|..|||||||||||
ekvkledgkikvlalseekeegyiltrlrleekgee..rrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

TLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
|| .. |... .     . | .....||..|   ||.  || .... |.||  
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0051429 (Phosphotyrosine protein) phosphatases II 249-469 2e-42 141.1 In-house 6-239 (272) alignment 
Range on Protein: 249-469
Range on HMM: 6-239/272.0
YIHANLVSSGPN---PRRFICTQAPLNGTIEEFWKMiIVTGIEYIVMLCELVEKGKPKSAEYFP----------SQIGQTTKIGRLCTVTKESRVDIDKT
||.|. |.   .   |.|......||. |...||..    || .||.|....|.|. |   | |          .   .|  .|.|.  . .  .  | .
yiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyi

LVMSTMRISKPGDNAvvKIVKHIHWRNWPDHGVPDNFlsPFRLLTVVKNcTKPIVVHCSAGVGRTGTLALILIILESICLPDFIG--------VPRLLAK
| . ....  . ..|    | |.|...|||||||..     .|| .. .  .|..||||||..||||....|..|. ..| . .         . . ...
lrellltlllsagea..revmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeavee

LREERFRAVQTEMQYLYAHRCVLEYlaLKKYVQSREDFAKFA
||. |  |||||.|||. ....||.  |... ..|... . |
lraqrpgavqteeqylflyeallel..lrsllsvraeyllaa
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 202-467 2.8e-42 139.7 In-house 22-291 (315) alignment 
Range on Protein: 202-467
Range on HMM: 22-291/315.0
KKEYRDSPNEAPED-IATSFLGNPTRNRYRNIPCCDITRVKL---TDDPH-FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCEL
 .|..| |.  .    ..    | ..|||.||   | .||||    |.|.  || |  . |  . . .|..|.||. ....||.|.. . .  |||. ..
seefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkk

VEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTlvMSTMrISKPGDNavVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKN----CTKPIVVH
 |  | | . |.| . ..... | .   . .   | | .  .  . . . ...   . |   ....|||.||. .  | ..|.  ||      . ...||
qegdkikcrqywPdrkadsvefGsikvellsleadtdgv..arkl.vtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvh

CSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDFAK
||||||||| .  |  ... |   . . | ... .||..|   |||| .| . .  |||.|  .. .     |. 
csaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftd
subfamily_PTPRG_pd Subfamily PTPRG 196-461 3.5e-42 139.4 In-house 16-295 (563) alignment 
Range on Protein: 196-461
Range on HMM: 16-295/563.0
NGVAGLKKEYRDSPNEA-PEDIATSF---LGNPTRNRYRNIPCCDITRVKLTDDPH-----FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTG
.|  |...|. .  .|  ..|. ...     |  .||| ||   | .||||.. |       || || .      . || || ||. |.. ||.||    
dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

IEYIVMLCELVEKGKPKSAEYFPSqiGQTTKIGRLCTVTKESR---VDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLspFRLLTVVK
 . |||. .|||.|. |   |.|.   .. ..| |    .|.    .   .|||.  ... |  .   .| |.. |. .|||||||.  |  . |  |.|
vaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehsl..pvLifvkk

NC------TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQS
.       . |||||||||||||||.  .  .|. |   . . | ..| ..| .|   |||| ||.. |  .|| .| |.   .
ssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell
subfamily_Ptp69D_pd Subfamily Ptp69D 200-473 3.9e-42 139.4 In-house 23-303 (307) alignment 
Range on Protein: 200-473
Range on HMM: 23-303/307.0
GLKKEYRDSP-NEAPEDIATSF-LGNPTRNRYRNIPCCDITRVKLT----DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVML
||.|||.  . .| . .  .|    |  .||| .|   | |||||.    ..   || |. . .  . ..||. |.|...||..||.||    .. ||||
glakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

CELVEKGKPKSAEYFP-SQIGQTTKIGRLCTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIVKHiHWRNWPDHGVPDNFLSPFRLLTVV----KNCTKP
 .| || . | | |.|  .. |  .|   .  ...    | ..| .|..  . .  ..  |.|.. |. .|.|  ||.   . ..|.. |    |.   |
snlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqy.hytgWkDskvPevargllklieqvrelyklnrsP

IVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAlkkYVQSREDFAKFAKDYE
|||||||||||.|..  . ..|. . . | . .     .||..|   ||   || . .| .|.|     | .. ||  .... .|
ivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss...ygdtdedvddledaie
subfamily_PTPRK_pd Subfamily PTPRK 192-452 1.4e-41 137.4 In-house 15-277 (314) alignment 
Range on Protein: 192-452
Range on HMM: 15-277/314.0
LVLQNGVAGLKKEYRDSPNEapEDIATSfLGNPTRNRYRNIPCCDITRVKLT---DD-PHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGI
|. ..   |.|.||   ..    | |     | ..||. .|   | .||.|.   .|    || |.|. |  .|. || || ||. |...||...   . 
llkraegygfkeeyeslfeg..wdaakk.denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydenc

EYIVMLCELVEKGKPKSAEYFPSQIGQTTKIgRLCTVtkesRVDIDKTLVMSTMRISK-PGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT
  |||| ||||.|. |  .|.| .  .  .| ..  |    ...... ||. ..|..|       ...|..... .||||.|| .  . ..|.  ||. .
asivmltelvevgrvkClkyWPedtevygdi.kvelv....etellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksq

K----PIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE-Y
.    .|||||||| |||||   | |.|. |   . . |     .||...   |.|| || . .  .||  
eeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileac
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 200-454 2e-41 136.9 In-house 6-269 (274) alignment 
Range on Protein: 200-454
Range on HMM: 6-269/274.0
GLKKEYRDSPNEApEDIATSFLGNPTRNRYRNIPCCDITRVKL-----TDDPHFYIHANLVSS-GPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVML
 |.||. . | .  .   ..  |. |.|||..|   . .|| |     .|.   || || .   . . . .. || ||  |...||.||  . .. ||||
dlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

CELVEKGKPKSAEYFPSQIGQ--TTKIGRlCTVTKESRVDIDKTLVmSTMRISKPGDnavVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC------
 .| |. . | |.||| ...   . . |    .. |. |. ..  |  .. ...  .    . |||. . .|||| .||.  . ..|.. |..       
tklkeaneqkCavyfPdaedyeiserygd.veikvekiverndysv.rklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeena

-TKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
 . |.|||||||.||||    |.| .  .    .. | .. ..|| .|   |||. || . || . .|| 
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPRA_pd Subfamily PTPRA 219-453 2.7e-41 136.5 In-house 54-295 (330) alignment 
Range on Protein: 219-453
Range on HMM: 54-295/330.0
SFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQiGQ
|   |  .||. ||   | .|| |.     .   || |  .    .  .|| .| |.. |.|.||.||       |||| || |. . | | |.|.. | 
skeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde.Gl

TTkIGRLCTVTKESRVDIDKTLVMSTMR-ISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCT----KPIVVHCSAGVGRTGTLALILII
 |  | .    ... | .| |.    .. ...  ..  ...|. .|.. ||| ||| .    ..||  ||..      |||||||||||||||.  .  .
vt.yGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldav

LESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|| .     . | . . .||  | . |||..|| . .. .||| 
lervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPN1_pd Subfamily PTPN1 219-452 3.2e-39 129.4 In-house 28-270 (290) alignment 
Range on Protein: 219-452
Range on HMM: 28-270/290.0
SFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIG-QTTK
 .  | ..||||..   | .|.|| ..   || |.||      |..| || ||  |.. ||.|.       .||| ..|||.. | |.|.|..   .. .
klpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekell

IGRLCTVTKESRVDIDKTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPD------NFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILE
.       |  . .. .. ....... .       . . | |.  ||| |||.      .||   |   ....   | |.|||||.||.||..|.  .| 
ledtklkvkliseerksyytvrllelenlkt.qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclv

SICL---PDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEY
 |      . . . . | .||. |.  .||  |  ...  .|| 
liekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 213-457 7.7e-39 128.4 In-house 25-274 (285) alignment 
Range on Protein: 213-457
Range on HMM: 25-274/285.0
PEDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVS-SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQ
|.   |..  ||  ||| .. | . ||| | .  . ||||. .   | .   .| || ||  |. .||.||    | |..||| |.| |  | | |.| .
pnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

IGQTTKIGRLCTVTKESRV-DIDKTLVmSTMRISKPGDN-AVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVK---NCTKPIVVHCSAGVGRTGTLALI
.|.  |.|.      | .   |  |..  .. . .  |  .    ..|..   |||.  |..      |   ||      |||.|||||||||| |.  |
lgevvkfgkyeitlteckeeaiagtil.naltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgi

LIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
      |     | .  .. ..|  ||.|||. ||.|. .  ..||.  . 
dyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigeg
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 199-453 2.2e-38 127.0 In-house 24-279 (315) alignment 
Range on Protein: 199-453
Range on HMM: 24-279/315.0
AGLKKEYRDSPNE--APEDIATSfLGNPTRNRYRNIPCCDITRVKL---TDDPH-FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVM
 |.|..|   |     | |.|     |  .||| ||   | .||.|     |||  |. ||..     .||.|..|.|.  ....||...    |  |||
ngfkqdyesipggqlhpldvakk.ienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivm

LCELVEKGKPKSAEYFPSQigqTTKIGRLcTVTKESRVDIDKtLVMSTMRISKpGDNavVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVK----NCTKP
| .|||. | |. .|.| .       |.. |||. |    .. . . |. .   |||  .. |  .|.  ||| |||   ..   |   ||    |   .
ltnlvegekrkaekywpdk...kviyGki.tvtrkseevnte.ytvrtlsvvf.gdn..irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvga

IVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
||||||||||||||.  .  .|. .   . | | ... ..|. | ..||.  || . .  .|| .
ivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 196-468 4.5e-38 126.3 In-house 31-306 (319) alignment 
Range on Protein: 196-468
Range on HMM: 31-306/319.0
NGVAGLKKEYRDSPNEAPEDIATSFL---GNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIE
. .  |. |.|  .. ...    .|     |  .||. ||   | ..|||      .   || |  |.   .. ..| .| ||. |...||.||    . 
ddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncs

YIVMLCelvekgKPKSAEYFPSQIGQTTKIGRLCTvtkeSRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTV------V
 ||.|       | | ..|.| .| .. . . .      . |.  .  |.  ...|. | .  .. ..  |.. |||.||||     .||.         
tivllt......kdkcsqywplkivikeerfkvkv....dsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltsk

KNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDFAKF
.|  ..|||||||||||||.   . ..|. .   . . | ...  ||..| . ||  .|| . .  .||   . .   .  ||  .
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpay
0046846 (Phosphotyrosine protein) phosphatases II 240-453 6.7e-38 125.5 In-house 5-173 (176) alignment 
Range on Protein: 240-453
Range on HMM: 5-173/176.0
VKLTDDPHFYIHANLVSSGpnprRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTkigrlctvtkesrvdidktlvms
.   | .  ||.|||. ..    |.|.||.||..|...|..|.   ||...|.|.|.||.|. | . |.|   .                          
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

tmriskpgdnavvkivkHIHWRNWPDHGVPDNfLSPFRLLTVVKNCT---KPIVVHCSAGVGRTGTLALILIILEsiclPDFIGVPRLLAKLREERF-RA
                 .... .||||||||     ..||  ....    .|..||||||.||||||......        .. |   ||..|| |. .|
.................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplga

VQTEMQYLYAHRCVLEYL
|||. || . ....|..|
vqtpeQyrflyefellll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 222-468 3.8e-37 123.3 In-house 24-270 (284) alignment 
Range on Protein: 222-468
Range on HMM: 24-270/284.0
GNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCelvekgKPKSAEYFPSQIGQTTK
 |  .||. .|   | ..|||      .   || |  ..   .. ..| || ||. |...||.||    .  ||.|       | | ..|.| .| .. .
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

IGRLCTvtkeSRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTV------VKNCTKPIVVHCSAGVGRTGTLALILIILE
 ...      . |.  .  |.  ...|. | .  .. ..  |.. |||.||||     .||.         .|  ..|||||||||||||.   . ..|.
rfkvkv....dsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld

SICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDFAKF
 .   . . | ... .||..| . ||  .|| . .  .||   . .   .  ||. .
rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpay
subfamily_PTPN14_pd Subfamily PTPN14 219-454 1.7e-36 120.8 In-house 45-297 (300) alignment 
Range on Protein: 219-454
Range on HMM: 45-297/300.0
SFLGNPTRNRYRNIPCCDITRVKLT---DDPHFYIHANLVS--SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQ--
.   |  .||....   . .||.|.   .. . || |  ..   | . | .| .|.||. |...||.|.  .|.. |||| |  |.|| || .|||..  
klpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles

IGQTTKIGRLCTVTKeSRVDIDkTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPDN---FLSPFRLLTVVK----------NCTKPIVVHCSAGVG
  .| . |.   .||  . | | ... .....         . | |. . .|||||||..   |||  . .  |.          .   |..||||||||
kkktvefgkfkvttk.fsedsd.svittglklkhlps.keertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
||| | |  ......   . | ... ||.||| |   |||  || . .. ...|| 
rtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0043147 (Phosphotyrosine protein) phosphatases II 244-446 2.8e-36 120.2 In-house 2-154 (172) alignment 
Range on Protein: 244-446
Range on HMM: 2-154/172.0
DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELvekgkpksaeyfpsqigqttkigrlctvtkesrvdidktlvmstmri
|... ||.|....    |.|||.||.||. |...||.|.   || .||.|.||                                               
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

sKPGDNAVVKIVKHIHWRNWPDHGVPdNFLSPFRLLTVVKN-----CTKPIVVHCSAGVGRTGTLALILIILesiclpDFIGVPRLLAKLREERFRAVQT
       ... . .... .||||||| ..    ..|  ...       .|..|||||||||||||......|        . .   .| .|| |. |||.
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqn

EMQYLYAH
. || . .
psqyrfly
0036282 (Phosphotyrosine protein) phosphatases II 248-446 4.7e-36 119.5 In-house 3-163 (174) alignment 
Range on Protein: 248-446
Range on HMM: 3-163/174.0
FYIHANLVSSGPNPRRFICTQAPLNgtieeFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSqigqttkigrlctvtkesrvdidktlvmstmriskpG
 ||.|. ..    ..|.|..|.||.     ||.|.   ||...|||.|..|.|. |   |.|.                                     
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................l

DNAVVKIVKHIHWRNWPDHGVPDNFLsPFRLLTVVKNC-----TKPIVVHCSAGVGRTGTLALILIILESIClPDFIGVPRLLAKLREERFRAVQTEMQY
 .  .. . .... .||||||||     ....  |...      .|..|||||||||||||......|  .. .... . .|...||  | ..|||. ||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

LYAH
 . .
rfly
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 223-457 1.8e-35 117.5 In-house 51-288 (297) alignment 
Range on Protein: 223-457
Range on HMM: 51-288/297.0
NPTRNRYRNIPCCDITRVKLT---DDP-HFYIHANLVSSGPNprRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKpKSAEYFPSQiGQTTkI
|  ..||.||   |  ||||    |||   |. |  | .  .  |.|.|| | . |...||.|..   .  |||| .. |. | | | |.. . | ||  
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk.gvtt.f

GRLCtVTKESrVDIDKTLVMSTMRISKpGDNAVVKIVKHIHWRNWPDHGVPD--NFLSPFRLLTVVKN-----CTKPIVVHCSAGVGRTGTLALILIILE
| .  |. .| |.  .  .  .. ..| |.. . ..||  .. .|||. |.   .  |   |.. |..        |..|||.||||||| |  |. .. 
Gdvs.vvlls.vsereGfikrelevtk.gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvva

SICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
 .   . . .  |. |||.||   |||. || . .  |||.|  ..
eakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 222-454 7.6e-35 115.2 In-house 45-284 (290) alignment 
Range on Protein: 222-454
Range on HMM: 45-284/290.0
GNPTRNRYRNIPCCDITRVKLT------DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQigQT
 | ..||..||   |  |. |       | .. ||.|  .    . ...| ||.|.. |. .|||.|    .  ||||.. .|.|| |   |.|..  .|
snkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dt

TKIGRLC-TVTKESRVDidkTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHG-VPDNF--LSPFRLL--TVVKNCTKPIVVHCSAGVGRTGTLALILII
...|    ....|. ..   . .  .... .   ..  ..|.. .  ||...| |...   |. ..    |  |.  ..||||||..|||....  . . 
kaygefsikllneetln...eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaatt

LESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLA
..       | |  .| ..|  .   |||. || . .. ||.|| 
inkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 210-455 1.8e-34 114.1 In-house 37-280 (287) alignment 
Range on Protein: 210-455
Range on HMM: 37-280/287.0
NEAPEDIATSflgNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFP
.|   .||..   |  .||...|   |  || | .  . || |  . .  . ..|| ...|.  |. .|||.|    .. |||||.. |. . .  .|.|
devthniasq...nkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWp

SQigQTTKIGRLCTVTKESRvdIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHG-VPDNFLSPFR----LLTVVKNCTKPIVVHCSAGVGRTGTLA
..  ... .|       .    . .  .. .... . . ..  . ||  .  ||...| |..   . .       |  |.   .||||||..|||.... 
ee..ksvvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfc

LILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLAL
 . . ..       | | ..| . |  .  .|||  || .    |||||  
aaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
0049772 (Phosphotyrosine protein) phosphatases II 219-455 2.2e-33 111.7 In-house 42-282 (314) alignment 
Range on Protein: 219-455
Range on HMM: 42-282/314.0
SFLGNPTRNRYRNIPCCDiTRVKLtD----DPHFYIHANLVSSGpnpRRFICTQAPLNGTIEEF----------WKMII--VTGIEYIVM----------
... |...||| .|.. | .||.| .    . . ||.|. |..    ..||.||.||. |.. |          |.|..     . .|||          
dlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------LCELVEKGkpksAEYFPSQIGQTTkigrlctvtkesrvdidktlvmstmrisKPG--DNAVVKIVKHIHWRNWPDHGVPdNFLSPFRLL
           |..| ..|    .|. .. . .                              .    .. . . . . .. ..||...|  .    ..|
srLdaAlgKtpllildgng....neptaadlellk............................eelydpelferlgikylripvpDgsap.lledfdefl

TVVKN--CTKPIVVHCSAGVGRTGT--LALILIILESICLPDFIGVPRLLAKlREERFRAVQTEMQYLYAHRCVLEYLAL
 ....    .|..|||.||.|||||  .| .|..|  ..| . .   ||       ....... .||.. ....||||  
efieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleylkf
0049260 (Phosphotyrosine protein) phosphatases II 260-446 2.8e-33 110.1 In-house 7-143 (152) alignment 
Range on Protein: 260-446
Range on HMM: 7-143/152.0
NPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFpsqigqttkigrlctvtkesrvdidktlvmstmriskpgdnavvkivkHIH
.|..||.||.|.. |...||.|.   || .||||.||.|.||.| ..|.                                                ...
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................qyl

WRNWPDHGVPDNFLSPFRLLTVV----KNCTKPIVVHCSAGVGRTGTLALILIILesiclpDFIGVPRLLAKLREERFRAVQTEMQYLYAH
. .||||||||.      || ..    ..  .|..|||||||||||||......|        . .   .| .|| |  ||... |. . .
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 213-452 3.1e-32 106.6 In-house 24-265 (283) alignment 
Range on Protein: 213-452
Range on HMM: 24-265/283.0
PEDIATSfLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVS---SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFP
. |||..   |.. ||...|   |  ||.|  ... || |  .    |  . ...| .|.||. |. .||||.    |  |||| .| |  . | . |.|
dadiasa.denkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

SQigQTTKIGRLC-TVTKESRvDIDKTLVMSTMRISKPGDNAVVkiVKHIHWRNWPDH--GVPDNFLSPFRLLTVV--KNCTKPIVVHCSAGVGRTGTLA
..   . . | .  |. ||       .    ..| .    ....  . |    .| .   . . | |  | ..     ..   |||||||.|.|||... 
kr..GsedyGeftvtlrkett.snsfiikelllrvnssakstll..lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

LILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEY
 .   .. .     . |.  .  .||.|  ||||  ||   |  ||| 
aasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 222-453 5.7e-32 105.6 In-house 37-277 (287) alignment 
Range on Protein: 222-453
Range on HMM: 37-277/287.0
GNPTRNRYRNIPCCDITRVKLTDDPHF---YIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQiGQTTKI
 .  .||| ..   | ||| |. ....   || || |.|  .  .||..|.|.  |. .||.... |    ....   ||... |  .|.| .  .  ..
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrv

GrLCTVTKESRVDIDKTLVMSTMRISKPgDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVV---------KNCTKPIVVHCSAGVGRTGTLALILII
|   .|.  ..   .    . ..|. .  .    ..|| ... .|||....   ..  |.   |          . . |.|||...|.||.|.|  .|..
G.GysvvlldydikePeygvralrlidl.etrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

LESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
..       . | . ...||| |   ||. .|. .    .  | 
vsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_egg_pd Subfamily egg 219-453 7.5e-32 105.2 In-house 35-270 (307) alignment 
Range on Protein: 219-453
Range on HMM: 35-270/307.0
SFLG-NPTRNRYRNIPCCDITRVKLTDDPH-F---YIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKgkPKSAEYFPSQIG
..   | .. | . ..| | .||||      .   .|||| |. .|    ||..||||  | ..||.|.    ..|||||   .|    .   |.|    
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaes

QTTKI--GRLCTVTKESRVDIDKTLVMSTMRIskPGDNAVVKIVKHIHWrnwpDHGVPDNFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILE
.. ..  | |   . .     |  . .. ...   | .   . ..|  .    |     .  ||.|.|  ..| .||.||..  || ...||  | | | 
dslvtvpGslrienlkvdskadplfrvtklkl..vGgddeerflehwqg....dvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiall

SICLPDF--IGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
|.         | |    || .|  .|.. ..||. .| || ..
sllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 202-453 8.4e-32 105.6 In-house 26-288 (325) alignment 
Range on Protein: 202-453
Range on HMM: 26-288/325.0
KKEYRDSPNEAPEDIATS-FLGNPTRNRYRNIPCCDITRVKL---TDDPHF-YIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCEL
 .|.   |.. .    ..    |  .||..|.   | .|| |    |||.  || |. . .  .   |. .||||  ||...|....      .|.| ||
ahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlnel

vEKGKPKSAEYFPSQIGQTTKIGRLcTVTKESRVDIdKTLVMSTMRISKPGDnAVVKIVKHIHWRNWPDHGVPDN---FLSPFRLLTVVKNC-------T
 ..|| . | |.| ..|.. . | |  |   .  .|    |.  . . .. .    . ||  ... |.| ||.     ..|  .|.  |...       .
.dlgkdrcavywpkemgksktfGgl.evklrtieei.sdyvhrvldvkqvkk.GetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkas

KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
 ||.|||||||||||... .  .|. .     . .   . |||..|   |.|  ||   . .. |..
tpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 224-465 1.2e-31 104.6 In-house 49-291 (439) alignment 
Range on Protein: 224-465
Range on HMM: 49-291/439.0
PTRNRYRNIPCCDITRVKLTDD---PH-FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKpksaeYFPSQigQTTKIG
 |.|||...   | ||| | .    ||  || || .    ... .| ||.| . | ..||...|      ||||..|||  |     |.||.  . .  |
qtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcyg

RLcTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPD--NFLSPF-RLLTVV--KNCTKPIVVHCSAGVGRTGTLALILIILESIC
 . .|  .  ... .  .     . .   .   . | ..|.  |||. ||    ... | | .     |. . |.|||||||||||||.  . | || . 
di.avrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk

LPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDF
| . . .  ..  ||..| . ||.  ||.. . .||| .   .   . ..|
lenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
PTPc_DSPc_SM00012 355-451 4.3e-29 96.2 In-house 2-105 (105) alignment 
Range on Protein: 355-451
Range on HMM: 2-105/105.0
VKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTK------PIVVHCSAGVGRTGTLALILIILESICLP-DFIGVPRLLAKLREERFRAVQTEMQYLYAHR
|||.|. .|||||||..  | ..||  ||....      |.|||||||||||||.... |.|....   ... . ... .||..| ..||||.|||. .|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CVLE
..||
alle
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 224-451 1.1e-28 95.0 In-house 4-237 (237) alignment 
Range on Protein: 224-451
Range on HMM: 4-237/237.0
PTRNRYRNIPCCDITRVKLTD--DPHFYIHANLVSS-GPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQiGQTTKIGR
  .||| || . | .|| |        || |. . .    |...|..| ||. . ..||.|.       ||||  |.|. . |  .|.||   | .  | 
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygv

LCTVTKESRVDIDKTlVmSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTV-VKN-----CTKPIVVHCSAGVGRTGTLALILIILESIC
|    |      | | |  .. .|| .    |....  ..  |||.|||..  . .|.    ...      . | ..|||||||||| . .|  .|    
ltvslkkkeefsdyt.v.rslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

LPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
    . .   .  . |.|   .||. ||.. |. .||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
0051082 (Phosphotyrosine protein) phosphatases II 249-450 4.3e-28 93.2 In-house 5-150 (151) alignment 
Range on Protein: 249-450
Range on HMM: 5-150/151.0
YIHANLVSSGpnprrFICTQAPLNgtieEFWKMIIVTGIEYIVMLCELVEKGkpKSAEYFPSQIgqttkigrlctvtkesrvdidktlvmstmriskpgd
||... | .|     ......||.    .|....   || .||.|....| |  . .||.|..                                     
yinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................................

navvKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC-TKPIVVHCSAGVGRTGTLALILIILESiclpdfIGVPRLLAKLREERFRAVQTEMQYLYAHR
      |.||.. .|||.|.|..| .  ..| .. ..  .|..||||||.||||||......|.       . .   |. .|. |. .||...|.|. ..
....ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

CVL
..|
all
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 223-451 5.8e-28 92.7 In-house 7-238 (239) alignment 
Range on Protein: 223-451
Range on HMM: 7-238/239.0
NPTRNRYRNIPCCDITRV---KLTDDPHF-YIHANLV-SSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQigqTTK
| ..||| ||   | .||   ||..|||  || |. .     .|. .|.||  .. .  .||.|.       ||||  |.|  | |  .|.|     |.|
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tsk

IGRLCTVTKESRVDIDktLVMSTMRISKPGDNAvVKIVKHIHWRNWPDHGVPDNFLSPFRLLTV-VK---NCTKPIVVHCSAGVGRTGTLALILIILESI
   |    ... |  |   .. |. .|. |.    . | . |.  |||.|||.   . . |     |     ..| |.||||||||||.. .|  .|   
ycnlrvtlrktevfad..yiirtfvmsqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

CLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
     . .   .  .||.| . |||  ||.. | .|||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 223-457 6.6e-28 92.3 In-house 40-297 (301) alignment 
Range on Protein: 223-457
Range on HMM: 40-297/301.0
NPTRNRYRNIPCCDITRVKLTDDPH------FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTT
| . ||..||   |  |. |.  |.       || |. ...  . ..|| .|.|.. |. .||..|.      |||...| |. | |. .|.|.   ...
nkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaese

KIGRLCTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIVK------------HIHWRNWPDHGVPDNFLSPFRLL-----TVVKNCTKPIVVHCSAGVGR
. | . .  ... |  | ..   ...| .  .|. ..                ..  .||..||  .     . .     .  |    |.|||||..|.|
efgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsr

TGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
.|.   . | ||       . |  .   .|  .  ||.|  ||   .  . .||.|..
sGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlns
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 269-461 7.1e-28 91.9 In-house 98-296 (302) alignment 
Range on Protein: 269-461
Range on HMM: 98-296/302.0
APLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDID-----KTLVMSTMRISKPGD-NAVVKIVKHIHWRN
 | . |.| .| .|    .  .| ||..||... | |||.  ..|.. | || .  |.. . |..     |.... |. |      ..| | |. ...  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPDNFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQS
||||| |..  . . .|   .   | ..|||||||||||||  |   ..     .   .  ..  .|. |. |||.| | .|   ||   |  |. |  
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmekagvly
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 223-451 7.4e-28 92.3 In-house 8-239 (239) alignment 
Range on Protein: 223-451
Range on HMM: 8-239/239.0
NPTRNRYRNIPCCDITRV---KLTDDPHF-YIHANLV-SSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQigqTTK
| ..||| ||   | .||   ||..|||  || |. .     .|. .|.||  .. .  .||.|.       ||||  |.|  | |  .|.|     |.|
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...tsk

IGRLCTVTKESRVDIDktLVMSTMRISKPGDNAvVKIVKHIHWRNWPDHGVPDNFLSPFRLLTV-VK---NCTKPIVVHCSAGVGRTGTLALILIILESI
   |    ... |  |   .. |. .|. |.    . | . |.  |||.|||.   . . |     |     ..| |.||||||||||.. .|  .|   
ycnlrvtlrktevfad..yiirtfvmsqvgqte.eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

CLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
     . .   .  .||.| . |||  ||.. | .|||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 204-457 1.3e-27 91.2 In-house 25-240 (392) alignment 
Range on Protein: 204-457
Range on HMM: 25-240/392.0
EYRDSPN--EAPEDIATSfLGNPTRNRYRNIPCCDITRVKL---TDDPH-FYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELV
|..| |.    |. .|     |  .|||.||   | .||||    | |.  |. |  . |  | . .|..|.|   ....||.|.    .  |.|. .| 
efhdlpgpdiypqtvaqk.einlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklk

EKGkpksaeyfpsqigqttkigrlctvtkesrvdidktlvmstmriskPGDNavVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVK----NCTKPIVVHC
|                                                ||.  .. |   |. .|||..||    | ....  ||    . |.|...||
egd.............................................kgdd..artvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihc

SAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
|||||||| .  |  ..       .. |  .....|..|   |||. || . . .||| |  ..
sagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrn
0044763 (Phosphotyrosine protein) phosphatases II 241-456 2.6e-27 91.0 In-house 8-174 (178) alignment 
Range on Protein: 241-456
Range on HMM: 8-174/178.0
KLTDDPH----FYIHANLVSSGpnprRFICTQAPlngtiEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGqttkigrlctvtkesrvdidktl
.|.  ..    .||.|. .  |     ..... |     .......   || .||.|.| .| |..|. .|.|.. |                       
llsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.......................

vmstmriskpgdnavvkivKHIHWRNWPDHGVPDNFLSPFRLLTVVK----NCTKPIVVHCSAGVGRTGTLALILIILESiclpdFIGVPRLLAKLREER
                    . .. ..||||||| .   ....  ..    .. .|..|||||||||.|||... ....       . ..  .. .|| |
...................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerR

FrAVQTEMQYLYAHRCVLEYLALK
. .|... |. . ... |..|. .
p.ivpnpgqlrqLyefelrllkes
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 223-452 6.2e-27 89.3 In-house 33-258 (267) alignment 
Range on Protein: 223-452
Range on HMM: 33-258/267.0
NPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKgkpKSAEYFPSQIGQTTKIGRLC
|  |||. .    | ||| | .  . || |  | .    . || || ||. || .|...|.  ..  ||.|    .    .   ..| ..||. |   | 
nqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakkyqdlt

TVTKESRVDIDKTLVMSTMRISkpgdNAVVKIVKHIHWRNWPDHGVPDNFLSPF-RLLT--VVKNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFI
      . . |  ..   ...     |   . |   ....|        .| |.  .|.   ..|  .|.||.||.||||.||.  |   || .   .  
vehslekeendyqiitlelkfk....nesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvs

GVPRLLAKLREERFRAVQTEMQYLYAHRCVLEY
 .  .| |.|. |   |.|  .|.| |. . ||
difdflrkirsqriglvdtkeryiyihellaey
subfamily_PTPRN_pd Subfamily PTPRN 217-451 6.6e-27 89.0 In-house 50-290 (297) alignment 
Range on Protein: 217-451
Range on HMM: 50-290/297.0
ATSFLGNPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLV-SSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQ
...   | ..||....   | .||||..    . ..|| |  .  . |    .| ||.||. |. .||.|.   |.  ||.|..| |.|  . ..|.| .
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

IGQTTKIGRLCTVTKesRVDIDKTLVMSTMriSKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC----TKPIVVHCSAGVGRTGTLALIL
  .. .|  .  |..   .  |  || |     |  ..   . |   |.  ||..||| .  | . .   |  .    . |||||||.|.||||.  || 
Gsevyhiyevhlvse..hiwcddylvrsfy..lknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

IILESICLP-DFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
..|. .      | .   | .||..|   |.|. |. .|  .| |
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 243-469 1.7e-26 88.0 In-house 45-275 (290) alignment 
Range on Protein: 243-469
Range on HMM: 45-275/290.0
TDDphfYIHANLVSSgPNPRRFICTQAPL-------NGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSA----EYFPSQIGQTTKIGRLcTVTKESRVD
.||   ||||| |.  ||  |.| ||.|.       | |||.|| |.    .. .|||||  || . .|     .|.| ..|.  |.. | ||   |.. 
ndd...yiHAnrvtc.pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgl.tvkCkskek

iDKTLVMSTMRISKpgDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIILESIC-LPDFIGVPRLLAKLRE
 .. . . .. .    |. .   |.|   ..| .  |... ..   |.  ||. . |..|||  |. |  .|| | .    |  . . . .  .| .||.
.eddvetRelvvkf..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

ERFRAVQTEMQYLYAHRCVLEYLALKKYVQSREDFAKFA
.|  |....... ..   .. ..   .   ..|.. | |
qralaitsalelafvdagivllaievldqfaeeetekka
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 274-481 4.1e-26 86.6 In-house 40-247 (255) alignment 
Range on Protein: 274-481
Range on HMM: 40-247/255.0
TIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKEsrvDIDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFL
|...|...|. |. | .||||.. |.|. |  .||| .  .  |.  .  .| .    . . ..     .|. |.    . ||| ... |...  |..  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

SPFRLLTVVKNCtKPIVVHCSAGVGRTGTLALILIILE----SICLPDFI--GVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKyvQSREDFAK
    .| ||..  |..|||||.|.||. ...|. ..      |.   . .     .|| .||..| ||..| .|  ..   ||...  |.  .  ... .
eilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg..eleakyqe

FAKDYEQALAMCPK
  | | .|  |  |
irksylharqmmhk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 225-380 8.8e-26 85.4 In-house 35-191 (297) alignment 
Range on Protein: 225-380
Range on HMM: 35-191/297.0
TRNRYRNIPCCDITRVKLTDDP--HFYIHANLVS--SGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGR
 .||||.|   | |||||   .  . || |. |     ... ..|..| ||. |...||...   ..  |||...| | |. | | |.||  ..  | | 
rknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagd

LCTVTKESRVDIDKTLVMSTMRISKPgdnAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLT
.      |  |  ...... ...      .  . |.|. . .||||||| ..    |. .
vvveflsstsdefdrviltelqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqa
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 198-459 2.8e-25 83.4 In-house 25-289 (302) alignment 
Range on Protein: 198-459
Range on HMM: 25-289/302.0
VAGLKKEYRDSPNE-APEDIATSFLGNPTRNRYRNIPCCDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTI---EEFWKMIIVTGIEYIVML
 | .|||.    .  .. .  ..|  |. .|.  ..|. | ..|||.  | .|..|  |.     |  | .| |  ..    ||||.|.    |  .|.|
taevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvil

CELVEKGKpKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTlVMSTMRI-SKPGDNAVVKIVKHIHwrNWPDHGVPDNFLSPFRLLTVV----KNCTKP
    |  |    |.|| . |. .. |..   ..      ...  . .. .  .   |.|.  |....  ||... ||... .  .  . |     .....
vgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvlt..nWkqkkvpvkyaeliktaakvfakkikaden

IVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLalKKYV
.|.    |.|| |..    . .|..   .   .  .....|..| |||..  ||   ....| |.  || |
tvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi..kkkv
subfamily_ptpA1_pd Subfamily ptpA1 223-411 5.5e-25 83.0 In-house 47-254 (418) alignment 
Range on Protein: 223-411
Range on HMM: 47-254/418.0
NPTRNRYRNIPCCDITRVKLTD----DPHFYIHANLVSsGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQT--T
| ..||| ||   . |||.|      .   || || .  |  |..||||| ||  || .||.|.       ||||    |. . |   |.| |||    .
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid.gaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

KIGRLC-------TVTKESRVDIDKTLVMSTMRISKPGDNavvKIVKHIHWRNWPDHGVPDNfLSPFR-LLTVVKNC----------TKPIVVHCSAGVG
  |              |   | .. ..   .|..  |.    . . . ..  |||| .||    ||| ||  . |             ||.||||||||
iygngnevfgtysvelveviqdpereiitrnirltfeget...rditqyqyegwpdhnipdh.tqpfrqllhsitnrqnqiipssdrnvpiivhcsagvg

RTGTLALILIILE
||||..  .|...
rtgtfctavimmk
subfamily_hpo-7_pd Subfamily hpo-7 272-478 6.7e-25 82.5 In-house 44-253 (263) alignment 
Range on Protein: 272-478
Range on HMM: 44-253/263.0
NGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVdidKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDN
  ||..|...|  |. | .||||.  |.|. |  .||| .  .  |.  .  .| ..     ..|. .   .|  |.   .. |||  .. |...  | .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpel

FLSPFRLLTVVKNCtKPIVVHCSAGVGRTGTLALILIILE----SICLPDFIG--VPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKKYVQSRE-D
. . ...| |..|  |..|||||.|.||.   ... ..      |.   . ..    .|| .||..| ||..| ||  ..   ||...      .  |  
areilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgeleak

FAKFAKDYEQALAM
. .  | | .|  |
yqeirksylharqm
subfamily_CG7180_pd Subfamily CG7180 226-453 1.3e-24 81.3 In-house 45-290 (296) alignment 
Range on Protein: 226-453
Range on HMM: 45-290/296.0
RNRYRNIPCCDITRVKLT----DDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKpKSAEYFPSQIgqTTKIGRL
.||. ..   | .|| |.    ..   || |  | |   .. .| |.|| . |..|||...   .|. .|.|..  .  | .  .|.| .    .. | .
knrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygei

C--TVTKESRVDIDKTLVMSTMR-----ISKPGDNAVVKIVKHIHWRNWPD-HGVPDN---FLSPFRLLTVV-KNC-----TKPIVVHCSAGVGRTGTLA
   .|....  .. .  .  | .       . . .| ..|||..... |.  . ||     ..   |   .. ..      ..|.||..| |..|.|   
fveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvyl

LILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
 | . || .   . . | . . .||..| . |..  .| |    .||..
aidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0048076 (Phosphotyrosine protein) phosphatases II 345-452 1.2e-20 69.1 In-house 37-142 (145) alignment 
Range on Protein: 345-452
Range on HMM: 37-142/145.0
KPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC---TKPIVVHCSAGVGRTGTLALILIILEsiclpDFIGVPRLLAKLREERFRAVQTEMQ
 .  . ... . .... .|||||||| .    ..|  ....    .|..|||||||||||||... ..|.       . ..  |...|. |. ||... |
tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgq

YLYAHRCVLEY
. . ....||.
lrflyefelel
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 218-451 2.5e-20 67.3 In-house 42-277 (303) alignment 
Range on Protein: 218-451
Range on HMM: 42-277/303.0
TSFLGNPTRNRYRNIPCCDITRVKLTDDphFYIHANLVSSGPNpRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTK
  |. |  .||. .. | | ..|||.|    ||||. .    . .. | || ||. |  .||.|||   .  ...|    |  |      || .      
nqfvknmdknrfvdvicldhskvklsds..syihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

IGRLCTVTKESRVDIDKTLVMSTMRISKPGDNAVVKIvkhIHWRNWPDHGVPDN----FLS-PFRLLTVVKNCT--KPIVVHCSAGVGRTGTLALILIIL
  |   | .  ||.. .  |.  . .|.   .. ...    |...||   .| .    |.   ..| .|... .  .| |    .|.||.||.||.    
eersirvgefkrvelgdgwvlkvlsvsngdyksflhv...hhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

ESICL-PDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
 |.      . . . | ..|. |. |||   |. . .  . |
lslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
0048179 (Phosphotyrosine protein) phosphatases II 346-447 9.2e-20 66.3 In-house 48-139 (144) alignment 
Range on Protein: 346-447
Range on HMM: 48-139/144.0
PgdnavvkiVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNC---TKPIVVHCSAGVGRTGTLALILIILesicLPDfIGVPRLLAKLREERFRAVQTEMQY
.        . .... .|||||||| .    ..|  ....    .|..|||||||||||||... ...    . . . .   || .|. |. ||... |.
e........giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgql

LYAHR
 . ..
rfLle
subfamily_CG42327_pd Subfamily CG42327 226-377 9.4e-15 49.1 In-house 31-185 (319) alignment 
Range on Protein: 226-377
Range on HMM: 31-185/319.0
RNRYRN---IPCCDITRVKLTD-DPHFYIHANLVSSG-PNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQ-TT-KI
..|. |   .|   ..  . .| |  .|..|. |      |  .|..|..|. .  .||...       || |..| |.|  . |||.|.. .   |   
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

GRLcTVTKESRVDiDKTLVMSTMRISKpGDNAVVKIVKHIHWrNWPDHGVPDNFLSPFR
| .  ||   |   ..  ..||. . .  |.   . . |  . .|.. .|| .  . . 
Gdi.lvtlkgrev.kdryaistlllkr.vdkeesrelthywy.kwleaevPaeeaalia
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 353-461 9.1e-14 45.6 In-house 89-202 (440) alignment 
Range on Protein: 353-461
Range on HMM: 89-202/440.0
KIVKHIHWRNWPDHGVPDNFLSPFRLLTVV-----KNCTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHR
. .|. |.. |||.|||      ....  |     |    |..||||||.|||| .  .  ||      | | .  ..  .|..| . |||  || . | 
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvhe

CVLEYLALKKYVQS
.||| |     .  
avlegllcgdtlil
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 215-346 8.1e-13 42.8 In-house 38-187 (350) alignment 
Range on Protein: 215-346
Range on HMM: 38-187/350.0
D-IATSFLGNPTRNRYRNIPCCDITRVKLT------------DDPHFYIHANLVSSG-----PNPR-RFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCE
| | .. .   ..|||.||   . .||||               .  || || ..        ||  ..| |||||  |...|.|.|.  ... |..| .
DvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilslts

LVEKGKPKSAEYFPSQIGQT--TKIgrlcTVTKESRVDIDK-TLVMSTMRISKP
.|| .  |  .|..    .    |.    . ..|. ..|.. .|  . ...  .
dvelnlekcyrYWqegsydditvkl....askwenimgindsslysadvkkeas
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 262-405 2.7e-12 41.3 In-house 4-153 (198) alignment 
Range on Protein: 262-405
Range on HMM: 4-153/198.0
RRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTLVMSTMRiSKPGDNAVVKIVKHIHWR
||.|.|| ||  |. .||.|.  ||  .|||. .   . .   . |.|.    |.| | |. .||   .  | |..   .  ..       . . |  . 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt.nnttappstreishyqft

NWPDHGVPDNFL-----SPFRLLTVV--KNCTKPIVVHCSAGVGRTGTLAL
 | ..  |.  |        | ..    ..   |..|||| | | || .  
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfva
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 262-405 2.9e-12 41.2 In-house 5-154 (199) alignment 
Range on Protein: 262-405
Range on HMM: 5-154/199.0
RRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVDIDKTLVMSTMRiSKPGDNAVVKIVKHIHWR
||.|.|| ||  |. .||.|.  ||  .|||. .   . .   . |.|.    |.| | |. .||   .  | |..   .  ..       . . |  . 
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalilt.nnttappstreishyqft

NWPDHGVPDNFL-----SPFRLLTVV--KNCTKPIVVHCSAGVGRTGTLAL
 | ..  |.  |        | ..    ..   |..|||| | | || .  
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfva
subfamily_CG42327_pd Subfamily CG42327 385-453 1.9e-11 38.2 In-house 246-315 (319) alignment 
Range on Protein: 385-453
Range on HMM: 246-315/319.0
CTKPIVVHCSAGVGRTGTLALILIILESICLP-DFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYL
   |.||||| ||||||..    | ..|.  .   . .|.|.  .|..| .||.|  || . .. . || 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_eak_pd Subfamily eak 223-369 4.2e-10 33.5 In-house 52-195 (332) alignment 
Range on Protein: 223-369
Range on HMM: 52-195/332.0
NPTRNRYRNIPcCDITRVKLTD---DPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIG
.  || .. .|  |   |.||    ..  || | |.      |..| | .. .  .  ||.|..      ||.| | ||..  ||  ||| .  .  | |
avnrnvvkivp.ydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfG

RLCTVTKESrVDIdKTLVMSTMRISKpGDNAvvKIVKHIHWRNWPDHGVP
 |   .||  |   . | .  . .|| |...  . |.| .   | .  .|
ildverkef.vkr.niletrllelsk.Gnet..hrvlhykvfGwtettlp
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 387-451 1.5e-09 32.2 In-house 229-293 (297) alignment 
Range on Protein: 387-451
Range on HMM: 229-293/297.0
KPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE
 ...|||||||||.| . |  .||. .       |  .| .|||.| | |||  |. . .  ||.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
0038934 (Phosphotyrosine protein) phosphatases II 354-409 1.2e-08 30.4 In-house 78-138 (194) alignment 
Range on Protein: 354-409
Range on HMM: 78-138/194.0
IVKHIHWRNWPDHGVPDNFLSPFRLLTVV-----KNCTKPIVVHCSAGVGRTGTLALILII
   ...   .||.|.. ..   .| | .|     ..  . ..||| ||.||||||.   .|
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLi
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 235-296 2.2e-08 28.0 In-house 58-119 (347) alignment 
Range on Protein: 235-296
Range on HMM: 58-119/347.0
CDITRVKLTDDPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCEL
 . ..   .||.. || |  .      . .| || ||  |. .||||. || .  .| . | 
peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
PTEN_1 359-405 1.3e-07 26.6 In-house 98-149 (196) alignment 
Range on Protein: 359-405
Range on HMM: 98-149/196.0
HWRNWPDHGVPDNFLSPFRLLTVVKNC-----TKPIVVHCSAGVGRTGTLAL
. . ..|||.|.       .  .   .      . ..||| ||.||.||.. 
lhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 249-308 1.6e-07 25.0 In-house 92-153 (349) alignment 
Range on Protein: 249-308
Range on HMM: 92-153/349.0
YIHANLVSSG--PNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYF
|| || ..       ...|.|||||  |...|.|.|.  |.. .. | .  |..  |   |.
yinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 384-457 1.8e-07 25.2 In-house 260-348 (350) alignment 
Range on Protein: 384-457
Range on HMM: 260-348/350.0
NCTKPIVVHCSAGVGRTGTLALILIILESI-----CLPDF----------IGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
. ..||.|||||||||||||  .  .|. .        ..            .  .. .||. | . ||.  |... . ..| | ||.|
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfaLrk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 389-457 2.9e-07 24.8 In-house 1-69 (69) alignment 
Range on Protein: 389-457
Range on HMM: 1-69/69.0
IVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
.|||||.| |||||.  |.. .  |    .. .   .  .|  |   |  |..|.. |  . | | | |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklGk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 385-457 8.5e-07 22.8 In-house 270-342 (347) alignment 
Range on Protein: 385-457
Range on HMM: 270-342/347.0
CTKPIVVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
   |.|| |  |. |. |. |  ||.| .       .  |. |.|..|       . | || |. | || || 
klapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyairaalfylklkl
subfamily_CDC14_pd Subfamily CDC14 377-408 1.3e-06 22.5 In-house 254-285 (328) alignment 
Range on Protein: 377-408
Range on HMM: 254-285/328.0
RLLTVVKNCTKPIVVHCSAGVGRTGTLALILI
..|.......  |.||| ||.||||||    .
kfleiaekaeGaiavhCkaGLGrtGtLiacyl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 390-457 1.4e-06 22.6 In-house 1-68 (69) alignment 
Range on Protein: 390-457
Range on HMM: 1-68/69.0
VVHCSAGVGRTGTLALILIILESICLPDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
|||||.| |||||.  |.. .  |    .. .   .  .|  |   |  | .|.. |  . | | | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklGk
subfamily_PTPDC1_pd Subfamily PTPDC1 362-443 3.3e-06 21.7 In-house 89-166 (182) alignment 
Range on Protein: 362-443
Range on HMM: 89-166/182.0
NWPDHGVP--DNFLSPFRLLTVVKNCTkPIVVHCSAGVGRTGTLALILIILESIclpdfIGVPRLLAKLREERFRAVQTEMQYL
 |.|.||.  .. |   .... . .    . ||| || |||| |    ..  .      .   . . ..|..| ...||  |  
gwkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqve
0048567 (Phosphotyrosine protein) phosphatases II 358-404 4.8e-06 21.0 In-house 40-95 (157) alignment 
Range on Protein: 358-404
Range on HMM: 40-95/157.0
IHWRNWPDHGvPDNFLSPFRLLT-------VVKNCTKPIVVHCSAGV---GRTGTLA
...  . |.| | |    .|. .       ..... |.|.|||.||    |||.||.
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLi
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 238-310 6.2e-06 20.5 In-house 8-71 (130) alignment 
Range on Protein: 238-310
Range on HMM: 8-71/130.0
TRVKltddPHFYIHANLVSSGPNPRRFICTQAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKgkpksAEYFPS
.|..     . ||.|..|    . . .. ||.||  |  .||||..   .. .|.|  . |.      ||.| 
srlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd
subfamily_CDKN3_pd Subfamily CDKN3 359-447 6.6e-06 19.8 In-house 103-190 (202) alignment 
Range on Protein: 359-447
Range on HMM: 103-190/202.0
HWRNWPDHGVPDN--FLSPFRLLTVVKNCTKPIVVHCSAGVGRTGTLALILIIlesiCLPDFIGVPRLLAKLREER-FRAVQTEMQYLYAHR
|    .| .|||    |  .  |..  .  .  .|||  |.||.  ..  |..     | |.|     ..|||. .  ||.||  || | . 
hhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclll....ylddtiepkdaidklrdlkgsraiqtvkqynylse
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 385-457 7e-06 19.6 In-house 264-348 (349) alignment 
Range on Protein: 385-457
Range on HMM: 264-348/349.0
CTKPIVVHCSAGVGRTGTLALILIILE--SICLPDF--IGVPR--------LLAKLREERFRAVQTEMQYLYAHRCVLEYLALKK
 . ...|||||| ||||.|  . ..|.  .    ..  | ..          . .||  |.  ||   |.   . ..|.|.||||
qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfalkk