Synonym: CELE_ZK484.7, ZK484.7
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
| Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
|---|---|---|---|---|---|---|---|---|---|
| subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 32-335 | 2.8e-194 | 638.7 | In-house | 1-304 (305) | alignment | ||
Range on Protein: 32-335
Range on HMM: 1-304/305.0
EKKTHRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNPRRFICTQAPLDKS
|||...|||.||||..||||||||||||.|||||||||||||||||||.||||||||||||.|||||..||||.|||||.||||.||.|||||||||.|.
ekkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplekt
CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIVKFESTGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRG
||||||||||.||..||||||..|||||||..|||.|||.||||||||.||.|||||....||.|...||.||||...||||. |.|||.||||||||||
cadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg
VPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLA
||.||.||.|||.|.||||||.||||||||||||||||.||||||||.||.||.|||||||||||||||||||.||||||||||||...||..|..|| |
vpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkea
HLAF
. ||
ykaf
|
|||||||||
| 0050432 | (Phosphotyrosine protein) phosphatases II | 28-322 | 6.3e-77 | 254.2 | In-house | 19-303 (308) | alignment | ||
Range on Protein: 28-322
Range on HMM: 19-303/308.0
GTTAEKKTHRKQIVKFVKNalEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLhpPWPHDYIHANFVSTP--SNPRRFICTQ
.. .|.. ....|.... ... .|..|| .. .. . ....... . . ||||||. ..||.|||| . ..|||.|..|... .||.||.||
ilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatq
APLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDK-PVLEFEekghKIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYH
.||.....||| |. ...| | ||....|.| .||. |. . . .||.. |. |.. |. . .. .| ...... .| .||..|
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg....kftvtllseev.......lddytvrtleltnlgdgesrtvthfh
WIDWPDRGVPTADMAIVELLAKTRPS--KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGqQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
...||| |||. .....| . | | .||.|||||||.|||| .......|.|| . . ....|.||||....|| .||||.....| |...|
ytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
K
.
l
|
|||||||||
| 0036941 | (Phosphotyrosine protein) phosphatases II | 52-333 | 6.5e-77 | 254.1 | In-house | 12-292 (297) | alignment | ||
Range on Protein: 52-333
Range on HMM: 12-292/297.0
PAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLhPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
.|.|. || . .. ...... . ||||||. ..||.|||| .. ..|||.|..|.... .|.||.||.||.....||| |.....| .| ||.
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt
NIMEKGAKKCCDYFACKDKPVLEFeekgHKIIVKFESTGKMkfeknTDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP--
. .|.| .||. |. . .|.. ....|.. |. .. ... .| ....|. .| .||..|...||| |||. ..... . |
elvelgrekcaqywpleegeslty....gdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl
----SKGPTVVHCSAGIGRTGSVVMIEYILDQLLG--GQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLAHL
|.||..||||||.||.|........|.|| . .. ....|.||||....|| .||.|.....|.... |... ..||..|
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll
|
|||||||||
| 0040438 | (Phosphotyrosine protein) phosphatases II | 39-331 | 5.1e-76 | 251.3 | In-house | 4-289 (317) | alignment | ||
Range on Protein: 39-331
Range on HMM: 4-289/317.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFeKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKSCADF
....... | .. .|. || . ... .. .. . ..||||.|. ..||.||||.|. . .|||.|..|..|. .|.||.||.||.....||
dlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF
WYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPVLEFeekgHKIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPT
| |. ...| .| ||.. .|.| .||. |. . .|.. ....|.. |. . .| || ....||. .. .||..|...||| |||
wrmvweqgvtvivmLteleelgrekcaqYwpl..getlty....gdftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvpp
ADMAIVELLAKTRPS----KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKL
....| . | . .||..||||||.||||........|.|| .... .......||||....|| .|| |.....|.|.. | .. . .|
spdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv.dveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel
A
.
k
|
|||||||||
| 0051299 | (Phosphotyrosine protein) phosphatases II | 35-318 | 9.1e-76 | 250.4 | In-house | 5-286 (288) | alignment | ||
Range on Protein: 35-318
Range on HMM: 5-286/288.0
THRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKS
. ....|.|.. | .|..||..|| .. ... ...|.. . . ||||.|. ..||.||||... . .|||.|...... ..|.||.||.||...
isveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpnt
CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPVLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-----PGGLAQKVTQYHWID
..||| |. ...| | ||....|.| .||. |. . .|.... | |.. |. . ....| ....|. ..| ..||..|...
vedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd....itvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytn
WPDRGVPTADMAIVELLAKTRPS----KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGqQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
||| |||. .....| . | . .||.|||||||.|||| .......|.||. . . . ......||||....|| .||.||....| |.
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
|
|||||||||
| subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 32-322 | 1.2e-75 | 248.9 | In-house | 4-293 (305) | alignment | ||
Range on Protein: 32-322
Range on HMM: 4-293/305.0
EKKTHRkQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMK-AFKEAQ----EHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNP-RRFICTQ
.|| . .||. ||. | || || . .. . . ||. | . ||||.|| | |.. |||. | | ||||||.| | | .||||.|
ppqthp.iveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaq
APLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFeeKGhKIIVKFEStGKMKFEKntDAKITETVFTVEGPGGLAQKVTQYHWI
|||.. .||.| .|.||. | |||. .| | ||..|. ||. |. |.|. | | .|. ||.| |.. . |. | . .|
gpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel..ks.givvenvs.gskpmer..daeiqitllnltysgdqkmsvrhlqwt
DWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
.||||||| . .. .|||. | || | ||||||||||||..| |||||... .. .... .|.|| |||.| ||||.|.|.||| |.|
ewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfleky
|
|||||||||
| subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 42-341 | 1.1e-74 | 246.2 | In-house | 5-300 (307) | alignment | ||
Range on Protein: 42-341
Range on HMM: 5-300/307.0
KFVKNALEKGPAGLRAEFAAMKRFNDF-EKMKAFKEAQEhgKNRYKDVGCLDHNRVKLH-PPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMC
.|...|.|| |. || . . . ..||. .. ||||.|| | |..|. .. . ||||||.. . .|..|||.| ||... .|| |.
pwvqrtldkgvqalvdefrvlakktpegvtveafsantd..knryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwama
LQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIVKFESTGKMKFEkntDAKITETVFTVEGpGGLAQKVTQYHWIDWPDRGVPTADMAI
.||||.|. |||...| . || .|. .. | | |... | |. ..|. . . | | . |. .. .. .... | .||||||| ...
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapd...edlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinlta
VELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLAHLAFTEKY
..|| .| . | |||||||.||.|..| | .. |... |. . .|.....|.||. .|||. |||..|.|.|.| |.. . | . |||
inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltknyeeky
MK
|
ak
|
|||||||||
| DSPc_SM00195 | 55-318 | 4.4e-74 | 244.5 | In-house | 2-262 (263) | alignment | |||
Range on Protein: 55-318
Range on HMM: 2-262/263.0
LRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
|..|| ... . .... .. ... |||||.. . ||.||||... ..|||.||...........|.||.||.. ..||| |...||| | ||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt
NIMEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMKfekntdAKITETVFTVEGPGG-LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-
. .|.| .|| .|. . . .|. || ||. .. |.| ..|. ...... | ..|||||.. .|||.||| . ..||| . . |
eeeengkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksk
---KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
.||.|||||||.||||..|.|..||..| .... . ..|....|.|| ...||..||||....||.|.
stssgpivVhCsaGvgRtgtfvtidiilskleeekkv.difeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
| PTPc_SM00194 | 55-318 | 4.4e-74 | 244.5 | In-house | 2-262 (263) | alignment | |||
Range on Protein: 55-318
Range on HMM: 2-262/263.0
LRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
|..|| ... . .... .. ... |||||.. . ||.||||... ..|||.||...........|.||.||.. ..||| |...||| | ||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt
NIMEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMKfekntdAKITETVFTVEGPGG-LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-
. .|.| .|| .|. . . .|. || ||. .. |.| ..|. ...... | ..|||||.. .|||.||| . ..||| . . |
eeeengkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksk
---KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
.||.|||||||.||||..|.|..||..| .... . ..|....|.|| ...||..||||....||.|.
stssgpivVhCsaGvgRtgtfvtidiilskleeekkv.difeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
| 0046845 | (Phosphotyrosine protein) phosphatases II | 54-322 | 1.5e-73 | 242.9 | In-house | 1-278 (284) | alignment | ||
Range on Protein: 54-322
Range on HMM: 1-278/284.0
GLRAEFAAMKRFNDFE--KMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTP-----SNPRRFICTQAPLDKSCADFWYMCLQE
||..|| .. ... . ...... . . ||||||. ..||.||||... . .|||.|..|... ....||.||.||.....||| |....
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq
KVDSIFMLCNIMEKGAKKCCDYFACKdKPVLEFeekgHKIIVKFESTGKmkfekNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVEL
.| | ||....|.| .||. |. . . ||.. ....|.. |. . . | .... | .|..| .||..|...|||.|||. ..|.
nvrvIVmltelvengrekcaqYwple.gevlty....gdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedllef
LAKTRPS------KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQ--IEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
| . | . .||.|||||||.|||| .......|.|| ... ......||||....|| .||.||....|.|.. |.
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
|
|||||||||
| 0045450 | (Phosphotyrosine protein) phosphatases II | 35-320 | 2.2e-72 | 239.7 | In-house | 9-306 (307) | alignment | ||
Range on Protein: 35-320
Range on HMM: 9-306/307.0
THRKQIVKFVKNALEKGPAGLRAEFAAMKRFND--FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFV--------STPSNPRR
.......|. | ....||..|| ...... ...... . . ||||||. ..||.||||... . .|||.|..| ... ..|.
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk
FICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKdKPVLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG--PGGLAQK
||.||.||.....||| |. ...| | ||.. .|.| .||. |. . . .|.... . |.. |. . ....| ....|. . | .
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh.......ldgytvrtlevtdldgtgesrt
VTQYHWIDWPDRGVPTADMAIVELLAKTRP------SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQI--EETDKILQKIREQRNNSIQTDQQYLFV
||..|...||| |||. ..... . | ..||..||||||.||||..... ..|.|| .. . .......|||| ...|. .|| |.
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl
HQVILNYCLD
....| ..|.
yeallelllk
|
|||||||||
| 0047943 | (Phosphotyrosine protein) phosphatases II | 51-318 | 1.7e-71 | 236.2 | In-house | 10-272 (273) | alignment | ||
Range on Protein: 51-318
Range on HMM: 10-272/273.0
GPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLhPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFML
|...|..|| ..... . ...... . . ||||||. ..||.|||| .. ..|||.|..|... .|.||.||.||.....||| |. ...| | ||
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmL
CNIMEKGAKKCCDYFACKDKP-VLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP
....|.| .||. |. . .|.... ..|.. |. . .. .| ...... | .||..|. .||| |||. ..|.. . |
telvelgrekcaqYwpleggelsltygk....ftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk
------SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|.||.|||||||.||||........|||| .... .......|.|| ...|| .||.|.....|.|.
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.vleavkllrsqRpgmvqtpeqyrflyealleyl
|
|||||||||
| 0043336 | (Phosphotyrosine protein) phosphatases II | 37-318 | 9.4e-71 | 233.8 | In-house | 4-277 (278) | alignment | ||
Range on Protein: 37-318
Range on HMM: 4-277/278.0
RKQIVKFVKNALEKGPAGLRAEFAAMKRFNDfEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCA
.|...|.... | .....|..|| . .|. . .. .. . . ||||||. ..||.||||.. ..|||.|..|.... ||.||.||.||.....
vkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve
DFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAckdKPVLEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGV
||| |. ...| .| ||.. .|.| .||. |. . .|.... . |.. .. . .. .| ....|. | ..||.||...||| ||
dFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygd....ftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgv
PTADMAIVELLAKTRP----SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|. ....| . | |.||..||||||.|||| .......|.|| .. . .......|||| ...||..|| |.....| |.
peslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd.leeavkelreqRpgavqtpsqyrflyealleyl
|
|||||||||
| 0039614 | (Phosphotyrosine protein) phosphatases II | 50-321 | 2.8e-70 | 232.5 | In-house | 29-292 (297) | alignment | ||
Range on Protein: 50-321
Range on HMM: 29-292/297.0
KGPAGLRAEFAAMKRFNDfEkMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTPSN-PRRFICTQAPLDKSCADFWYMCLQEKV
... .|..|| ...... . .. .. . ||||||. ..||.||||.|. .|||.|..|.... .|.||.||.||.....||| |. ...|
nsktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgv
DSIFMLCNIMEKGAkKCCDYFACKDKpvlefeeKGHKIIVKFESTGKmkfekntDAKITETVFTVEGpGGLAQKVTQYHWIDWPDRGVPTADMAIVELLA
.| ||.. .|.| ||..|. . . ... |.. .. . .. .| ....|. .| .||......||| ||| . |.|
tvivmLtklvelgr.kcaqywpeegg.......tygdftvtllkveh.......ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslelllefle
KTRP------SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
. | ..||..||||||.||||..... ..|.|| .... .......||||....||..|| |.....| ... |
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.vleavkelreqRpgavqtpsqyrflydallellkrk
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 81-316 | 2.8e-70 | 231.8 | Pfam-A | 3-235 (235) | alignment | ||
Range on Protein: 81-316
Range on HMM: 3-235/235.0
GKNRYKDVGCLDHNRVKL-HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPvlefEEKG
||||||. . |..|||| . . |.|||.||.|.. .....||.||.||.....||| |..|||| .|.||.. .||| .|| .|. ... ...
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee....slty
HKIIVKFEstgkmKFEKNTDAKITETVFTVEGPGG--LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK----GPTVVHCSAGIGRTGSVVMIEYI
..| |. . . ||. ....| ...... .. ..|.|.|. .|||.|||. ....|. | . || ||.|||||||.||||..|.....
gdikvelk.....ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
LDQLLGGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
|.|| ... . .|....|.||....|. .|| |....||.
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
|
|||||||||
| Y_phosphatase | Protein-tyrosine phosphatase | 81-316 | 2.8e-70 | 231.8 | In-house | 3-235 (235) | alignment | ||
Range on Protein: 81-316
Range on HMM: 3-235/235.0
GKNRYKDVGCLDHNRVKL-HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPvlefEEKG
||||||. . |..|||| . . |.|||.||.|.. .....||.||.||.....||| |..|||| .|.||.. .||| .|| .|. ... ...
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee....slty
HKIIVKFEstgkmKFEKNTDAKITETVFTVEGPGG--LAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK----GPTVVHCSAGIGRTGSVVMIEYI
..| |. . . ||. ....| ...... .. ..|.|.|. .|||.|||. ....|. | . || ||.|||||||.||||..|.....
gdikvelk.....ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil
LDQLLGGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
|.|| ... . .|....|.||....|. .|| |....||.
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
|
|||||||||
| 0045098 | (Phosphotyrosine protein) phosphatases II | 79-320 | 7e-65 | 214.5 | In-house | 33-274 (278) | alignment | ||
Range on Protein: 79-320
Range on HMM: 33-274/278.0
EHGKNRYKDVGCLDHNRVKlhppwphDYIHANFVSTPsnPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAckDKPVLEFeek
||||||. ..||.||| |||.|...... |..||.||.||.. .|||| |. .... .| ||.. .|.| .||. |. .. .|..
nldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp..eggslty...
gHKIIVKFESTGKMkfEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTAD--M---AIVELLAKTRP--------------SKGPTVVHCSA
... |...|. . .. | ... | .||| ... .||..|.. ||| |||. . . ..| . . . |.||..|||||
.gdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa
GIGRTGSVVMIEYILDQLlggQQIEETDKILQKIREQRNN-SIQTDQQYLFVHQVILNYCLD
|.|||| .|.. ..|..| .. .......|.||.. ..|. .|| |.....| . |
GvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
|
|||||||||
| subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 38-324 | 4.3e-64 | 210.9 | In-house | 12-289 (290) | alignment | ||
Range on Protein: 38-324
Range on HMM: 12-289/290.0
KQIVKFVKNALEKGPAGLRAEFA-AMKRF--NDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNPrrFICTQAPLDKSCAD
. . || .. .|.. .| |. .| . .. . | | . | ||||||| | | || |. . ||.|||.| . || || .| .. |
eafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkam..filtqGalkdtvid
FWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghKIIVKFEstgkmkfEKNTDAKITETVFTVE-GPGGLAQKVTQYHWIDWPDRGVP
.| | ||||| | |||...|.| || .|. |. || | | .. | |.. ||.| ...| | |. .. . |||. |.
iwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe...itvlcse.......eddkdaniikktlsvrdkdsGkehklkhlkikswpdksva
TADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKIlQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMF
...|.. .| | || ||||||||||||. | || |. || |.... | . . .|. | ||.| | ||| . ...|.. | | .
lstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlv.ralrnsrlnsvqvdiqylalveilldlGkdfkyi
|
|||||||||
| 0040439 | (Phosphotyrosine protein) phosphatases II | 76-320 | 1.2e-63 | 210.3 | In-house | 8-248 (249) | alignment | ||
Range on Protein: 76-320
Range on HMM: 8-248/249.0
EAQEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPV
. ||||.|. ..||.||||.. ...|||.|...... .||||.||.||.....||| |. .... .| ||.. .|.| .||. |. . .
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggs
LEFeekgHKIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP------SKGPTVVHCSAGIGRTG
||. ... |.. |. . ...| ...... | .|......|||| ||| ..... . | ..||..||||||.||||
ley....gdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG
SVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
.... ..|.|| ... . .....|.||....|...|| |.....| ..|.
tfiaaylmleqlekelgvd.leeavkllrsqRpgavqnpeqyrflyeallelllk
|
|||||||||
| 0042113 | (Phosphotyrosine protein) phosphatases II | 76-317 | 3.7e-63 | 208.5 | In-house | 6-242 (245) | alignment | ||
Range on Protein: 76-317
Range on HMM: 6-242/245.0
EAQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdKPV
. ||||.|. ..||.|||| |. . .|||.|..|... ...||.||.||.....||| |. .... .|.||.. .|.| .||. |. . .
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ges
LEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG-PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP-----SKGPTVVHCSAGIGRTGS
|.... ..|.. |. . ....| ....|. . . ..|..||...||| |||. . ....| | |.||..||||||.||||
ltygd....ftvtllseeh.......lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt
VVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNY
.... ..|.|| . . .......|.|| ...||..|| |.....|..
fiaaylmleqlekelgvs.leeavkelrsqRpgavqtpsqyrflyeallel
|
|||||||||
| subfamily_PTPRD_pd | Subfamily PTPRD | 36-318 | 4.3e-61 | 202.2 | In-house | 6-281 (564) | alignment | ||
Range on Protein: 36-318
Range on HMM: 6-281/564.0
HRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAqEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSC
. ... ..|.. .. . . |. ... . |.. .| |.| ||||... ||.||.|.. ||| |.|. . ... .| ||.|| ...
pvaelkehvaklkansdlkfeeeykkieegqqftweaankpa.NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaeti
ADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFackdkPVLEfEEKGHKIIVKFESTGKMKFEKNTDAKITETVftvegpGGLAQKVTQYHWIDWPDRGV
.||| |. .... .| || .. ||| .|| .|. | . .|. ...|..|.. ... .. |.... ...|.|.|...|||.||
edFWRmvweqnsstiVmltkleEkgkvkchkYW.....Pekg.tetygeltVtleeeeeladyeirtfklkkkk......ssesreVrqFhFtsWPdhgv
PTADMAIVELLAKTR----PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|. ....|. | | | .||.|||||||.|||| . |...|... .... ......|.||| .|| .|| |.|..||..
pesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvD.iyqyvkalrkqRnamVqteeQYiFiheaileal
|
|||||||||
| 0037934 | (Phosphotyrosine protein) phosphatases II | 73-317 | 1.1e-60 | 200.6 | In-house | 4-241 (243) | alignment | ||
Range on Protein: 73-317
Range on HMM: 4-241/243.0
AFKEAQEHGKNRYKDVGCLDHNRVKLhPPwpHDYIHANFVSTPsnPrRFICTQAPLDKSCAD----FWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAck
.. . . ||||.|. ..||.|||| .. .|||.||.. . | |.|.||.||.....| || |. ......| ||.. .|.|..||. |.
iallpenlsknrysdilpydhsrvkl.eg..sdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..
DKPvlEFEEkghkIIVKFESTGKmkfekntDAKITETVFTVEG--PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTR------------PSKGPTV
.. .... ..|.. |. ...| .....| ...| . |..||.. ||| |||. ....| ..| .|.||..
gev..tygd....ftvtllseeh.......lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvl
VHCSAGIGRTGSVVMIEYILDQLlggQqiEETDKILQKIREQRNN-SIQTDQQYLFVHQVILNY
||||||.|||| .... ..|..| . .......||||.. ..|| .|| |.....| .
VHCsaGvgRtGtliaaylmllll...g..vdleeavkllreqRpgkavqtpsqyrflyeallel
|
|||||||||
| subfamily_PTPRB_pd | Subfamily PTPRB | 32-322 | 4.9e-57 | 188.2 | In-house | 4-289 (293) | alignment | ||
Range on Protein: 32-322
Range on HMM: 4-289/293.0
EKKTHRKQIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPL
.|... ... ..||. .. ... |. .| .. ...|| ..|... ||||... ||.|||| . ||| ||... . || || || ||
skpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPl
DKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVlefeEKGhKIIVKFESTGKMKfekntdaKITETVFTVEGpGGLAQKVTQYHWIDWP
.. ||| |....|. | || ...||| .|| .|. ...|| | .| |.. .. ... . . ...| . .||.|||.. ||
petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv....lyG.dikvtlvaeeele.......dwvirelkiek.ekeerkvrqyhftsWp
DRGVPTADMAIVELLAKTR------PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
| ||| . ...... . | ||.|.|||||||.|||| . .. .|... . .. . |....||.||. .|| .||.|.||..|... .|.
dhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdif.givaelReeRnllvqtekqYifihqcvldllrkke
|
|||||||||
| subfamily_PTPN12_pd | Subfamily PTPN12 | 54-319 | 9.3e-55 | 180.5 | In-house | 16-278 (290) | alignment | ||
Range on Protein: 54-319
Range on HMM: 16-278/290.0
GLRAEFAAMKRFNDFEKMKAfKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFML
|... ...|. . ... .. .. .. ||||||. |..||.|. . ||| |||. .... ..| .|.|| | ||| | . .| . |.
klkklsekykaekvysteag.ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvma
CNIMEKGAKKCCDYFACKDKPVLEFEEkghkIIVKFEStgkmkfEKNTDAKITETVFTVEGPgGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-
|...| | ||| |.. . . |||.| . |. |. ||..| .. ..|| . .||.|.|. .|||.|||.. ..||... |
CrevelgkkkCerYWpeegeeelefge....fevtlee......ekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelq
---KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETD--KILQKIREQRNNSIQTDQQYLFVHQVILNYCL
. | |||||||.|||| .. |.|. ..| .. || | ......|.||. .|| .|| .|.. .....
esedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
|
|||||||||
| subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 40-317 | 4e-53 | 175.4 | In-house | 8-278 (288) | alignment | ||
Range on Protein: 40-317
Range on HMM: 8-278/288.0
IVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFW
|. |... .. .|. |. .. .. .. .| ..|. . ||||... .|..||||. ||| |... . ...|.||.|| .. |||
pvakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW
YMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLeFeekGHkIIVKfestgkMKFEKNTDAKITETVFTVegPGGLAQKVTQYHWIDWPDRGVPTAD
. ..|. | || ...|.| .|| .|. .|||.. . |. . |. .. .|... ..... . . ..|||.. ||| ||| .
elvyenktstivmltelveggktkCeeYWPdadkpkn.y...Gs.vtvt......lveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPesk
MAIVELLAK---TRPSK-GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDkILQKIREQRNNSIQTDQQYLFVHQVILNY
. ..||| . . ... || .||||||.|||| . .. ..|.. ..|. .. ...|.|.||.. .|| .|| |...|.|.
apllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvag.tvaklRkqRallvqtlkqYefiyevllsl
|
|||||||||
| subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 42-318 | 2.2e-52 | 172.9 | In-house | 4-276 (281) | alignment | ||
Range on Protein: 42-318
Range on HMM: 4-276/281.0
KFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYM
| .|. .. ||. |..... . . .| |. . ||||... |. |||..| ||| ||||.. ......| ||.|. .|...|| |
khlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqm
CLQEKVDSIFMLCNIMEKGAKKCCDYFAcKDKPvlefEEKGHKIIVKFEStgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMA
...||. | |. . .|.| || |. |. | | ...||... ... |. | .|..| .| ...|.| ... ||| |||. ..
vweqkvsaivmvtreieagklkChrYWP.ddns....elkygdvtvksta.......eeekatyierkfkleresgetreveqlaytaWPdhGvPattke
IVELLAKT----R-PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
..| .. . .| | |.|||||.||||. . .. ..... .. . . .....|..|| .|| || ||....|..
llefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
|
|||||||||
| subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 32-317 | 1.3e-51 | 170.7 | In-house | 6-289 (298) | alignment | ||
Range on Protein: 32-317
Range on HMM: 6-289/298.0
EKKTHRKQIVKFVKNALEKGPAGLRAEFAAMKRFND---FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTPSNPRRFICTQ
|... .... |... .|. .|. .|| ... .. |.... .. . . |||| |. ||. || |. ||| | |... .. || ||
eaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq
APLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFackdkPVLEFEEKGHkIIVkfestgkMKFEKNTDAKITETVFTVEGP-GGLAQKVTQYHW
||| .. .||| | .|.. .| || |. |.. |. |. | . |. |. | | .|.. |... . ..|. ..| | |.
aPltetvedFWrmvteedigtiVmltnleeldktkyhkyw.....Pdegketyge.itv.......sllskeefadlivrklkvskkkeekerevrqlhf
IDWPDRGVPTADMAIVELLAKTRPS---KG--PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNY
. |||.|||. ....||.| | | | | .|.||||.||.|. . |. .|... | .. .... .|..| ...|| .|| |.....|..
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvD.vfqvvkvlRkkrpgavqteeqYvfiyeavlea
|
|||||||||
| subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 42-333 | 1.8e-51 | 170.1 | In-house | 12-295 (319) | alignment | ||
Range on Protein: 42-333
Range on HMM: 12-295/319.0
KFVKNALEKGPAGLRAEFAAMKRFNDFeKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYM
. .|. ..| .|. || .| ... ... .. . . ||||... |. ||.| . ||| |.|. . . ..|| |||||.. ||| |
erlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrm
CLQEKVDSIFMLCNIMEKGAKKCCDYFackdkPVLEFEEKGhKIIVKFESTGKMKFEKNTDAKITETVFTVEGpgglaQKVTQYHWIDWPDRGVPTADMA
.|.. . ||... ||. |. |. | .||| | ..||. |. ... . |. . || .|..... .||| .||. ..
vWeeessivvmltklveklkvklkkyw.....peenfeeyG.rlivtleeeeeledyiirklklnkkssevet.....RevkhfqyteWpdhdvPekats
IVELLAK-----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCldkKMFDVDVKLAHL
...|| . ....|| |||||||.||||. .... .|... . .. .. ...| ||| .|. .|| |.....|.. ...| .... .|
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlD.vfstvsrlRtqRnimvqrpeqYkfiyealleav...eagdteievqdl
|
|||||||||
| subfamily_PTPN3_pd | Subfamily PTPN3 | 44-317 | 2.9e-51 | 169.0 | In-house | 8-274 (280) | alignment | ||
Range on Protein: 44-317
Range on HMM: 8-274/280.0
VKNALEKGPagLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPhDYIHANFVSTPSNP----RRFICTQAPLDKSCADFWYMC
.|..||.| . |.| . | . ...| . ... ||||.|. |. ||||. ||| ||.|. .. |.| || ||.|...|||.|
lkeglesGa..vlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmv
LQEKVDSIFMLCNIMEKGAKKCCDYFACKDkPVLEFEekghKIIVKFESTgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAI
..|. | || ...|.| .||. |. .. ||. .. || |.. ..| . .. . . .|..| ...||| |||. .
weqksslivmlttlverGrvkChqyWPete.deleyg....efsvkceke......detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadf
VELLAKTRPSK----GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDkILQKIREQRNNSIQTDQQYLFVHQVILNY
.|.. . | . |.|||||||||||| ....| | . ... | |....|.|| . .|| .|| || . ||.
lefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypld.ivrtmrdqramlvqtasqykfvCeailkv
|
|||||||||
| subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 39-318 | 4e-51 | 169.0 | In-house | 8-283 (305) | alignment | ||
Range on Protein: 39-318
Range on HMM: 8-283/305.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFekMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADF
.. ...|.| . || |.. .. . .. .. |. ... |||.|.. ||..|..| . . ||| |..| . .. ..| .|.||.. |||
dlaayikearvysdkgleaqykslyeeees..idvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadf
WYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFeeKGHKIIVKFESTGKMKFEKNTDAKITETvftvegpGGLAQKVTQYHWIDWPDRGVPTA
|.. ..||| .| ||....| | .|| |.. . . . || ....| |.| . .|.. . | .. . |.||. |||| |||.
WrliveekvstivmltklveggkdkCrqYWpesktekkef..gefsvelksektasdyieRklkisiede.......dkesrtvlqyqltdWPdhGvpqf
DMAIVELLAK----TRPSKG-PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
....|. . . .|| | .||||||.|||| .... |..| .... ..|...|..| . .|| .|| |.|... ..
atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvd.vfevlkqlRskrmkmvqtldqYvflhdaldeli
|
|||||||||
| subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 41-319 | 8.8e-51 | 167.8 | In-house | 8-281 (318) | alignment | ||
Range on Protein: 41-319
Range on HMM: 8-281/318.0
VKFVKNALEKGPAGLRAEFAAMKRF-NDFEKMKAfKEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFW
. |.. |.| | .|. ...| . . ..|. | . |||| .. || ||||.. ||| ||.. . . .| .|||| . . |||
eshvrrlresGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfW
YMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvLEFEekghKIIVKFESTGKMKFEKNTDAKITETvftvegPGGLAQKVTQYHWIDWPDRGVPTAD
| . . | || ...|.| .|. |. |. ... |. |. ... ... |.|.| ..| |||. .|||.|||.
rmvWeqnsavivmltqeeergkakvhryWPskgs..rsyg....klvvelkeevelsdyvlrefkvtrt......eeeesrqvrqyhytsWpdegvpesg
MAIVELLAKTR-----PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
. ...|. ... ...||.|||||||.|||| .... .|... . .. .. ...||||| .||..|| |...|.|..
aslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvlleala
|
|||||||||
| subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 39-323 | 1.3e-50 | 167.1 | In-house | 5-276 (288) | alignment | ||
Range on Protein: 39-323
Range on HMM: 5-276/288.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFkeAQEHGKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYM
| ... |. . .|| |. . . ...| .. ..||... . | ||||. |. ||.|| ||. ..||.||.||||. .| |
vinawirlvlqiaveglkkeyrdspneasidiidsf..ianptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkm
CLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKghkiivkfESTGKMKFeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMA
|.. |. | |||...||| .| .|| | . . | | .. | .. ... .. .| .. | . |. .|.| ||| ..
llesdveyivmlcellekGkeksaeyfPsklGekarigrl........ctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenyls
IVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKM
. || . . | |||.|||.|||| ...| .|..| . ..|.| ||.| ..||| .|||.||...|.. | ||
plrllevlkslqkPivvhssaGvGrtgtlililialeslrl.ddflgirsllaklreerfkaiqtemqylyvhrcvleelllkky
|
|||||||||
| subfamily_PTPN6_pd | Subfamily PTPN6 | 36-320 | 1.8e-50 | 166.7 | In-house | 9-299 (306) | alignment | ||
Range on Protein: 36-320
Range on HMM: 9-299/306.0
HRKQIVKFVKNALEKGPAGLRAEFAAMKRF---NDFEKMKAFKeAQEHGKNRYKDVGCLDHNRVKL-HPPWPH-DYIHANFVS--TPSNPRRFICTQAPL
.... .. |. ... ||. || .... . ...... | .. . ||||| . ||.||.| .| | ||| ||... .... ...| || |
ieqrvselekeeeslekagfeeefeelqqeeakkllsrkegak.penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcl
DKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPvlefEEKGHKIIVKFESTgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWP
.. .||| | .||. | |. . .|.| .||. |. . . || |. . . ... ...| .. | . . . .. ...| |||. .||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek....eeyGkisvtnvsek......sladYilRelsvskkkkkkeerevfqyhfksWP
DRGVPTADMAIVELLAK----TRP----SKGPTVVHCSAGIGRTGSVVMIEYILDQLLG--GQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
| |||. |....| . .. ..||.||||||||||||....|. .|... . . |. ...||||. .||.||| ||...| .|
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
LD
et
|
|||||||||
| subfamily_PTPN1_pd | Subfamily PTPN1 | 67-316 | 2.8e-50 | 165.7 | In-house | 21-269 (290) | alignment | ||
Range on Protein: 67-316
Range on HMM: 21-269/290.0
DFEKmKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFA
||. .. |. .....|||.|| || |.||. ||| |..| . |..| || || . .. || | ..| .. || ...||. || .|.
dfpt.reaklpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP
CKDK-PVLEFEEKGHKIivKFESTGKMKFEKNTDAKITEtvftveGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS------KGPTVVHCSA
.... |..|. |. |. |. . .. . .... .......|.. ||| ||| . | ...| | | | .||.|.||||
qgeeekellledtklkv..kliseerksyytvrllelen......lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsa
GIGRTGSVVMIEYILDQLLGGQQI--EETDKILQKIREQRNNSIQTDQQYLFVHQVILN
||||.|...... .| .. ... . | | ..|..| ||| .| | .. ||.
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
|
|||||||||
| subfamily_PTPRG_pd | Subfamily PTPRG | 38-327 | 1.8e-49 | 163.4 | In-house | 4-296 (563) | alignment | ||
Range on Protein: 38-327
Range on HMM: 4-296/563.0
KQIVKFVKNALEKGPAGLRAEFAAMKR--FNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTPSNPRRFICTQAPLDKS
|. .| | . .| |. .|| |... .. .... .. ... |||| .. |. ||||.| .||| ||.. . || || || .
kefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt
CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkDKPvlefeEKGHKIIVKFESTGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRG
. ||| | ...| | |. |. |.|..|| |. |.. |. .. |. ... .. .| .. . ..|.|||. .||| |
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.des.....etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg
VPTADMAIVELLAK----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVD
||. . . | .. ||.|||||||.|||| .... .| |. ... . ..|..|| |||. .|| ||.|.|...|. . |. ..
vPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenav.nvfgflkhiraqRnflvqteEqYiflhdalleaiasketella
|
|||||||||
| subfamily_Ptp69D_pd | Subfamily Ptp69D | 45-320 | 5.4e-49 | 162.0 | In-house | 14-288 (307) | alignment | ||
Range on Protein: 45-320
Range on HMM: 14-288/307.0
KNALEKGPAGLRAEFAAMKRFnDFEKMKAFKEAQE-HGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCL
|. .. || |. ... ..| . | .| ||||.|. |..||||.. . ||| |.|. . . ..||. |.|.. ||| |
ksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmia
QEKVDSIFMLCNIMEKGAKKCCDYFACKdkPVLEFEekghKIIVKFESTGKMKFEKNTDAKITETVFTVeGPGGLAQKVTQYHWIDWPDRGVPTADMAIV
. .| | || |. || ||| |.. ... .|.||. |. |.. . . ..... .. | .||.|||. |.| || . ...
eqevtlivmlsnlteknrkkcakYWpie..devqyg....dilvklvseekhsdyiiReldvskkkees.gevedsrkvvqyhytgWkDskvPevargll
ELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
.|. . . ...| ||||||| ||.| .| .. .|.|| .... .. ...|.||| .| .|| |... .|.|
klieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdif.etvkdLrsqRnllvqsleqYvflyralldyssy
|
|||||||||
| subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 79-325 | 3.7e-48 | 158.8 | In-house | 50-293 (301) | alignment | ||
Range on Protein: 79-325
Range on HMM: 50-293/301.0
EHGKNRYKDVGCLDHNRVKLHPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEk
.. |.||. | | . |.. ||||...|. .|.|||.||.||.... ||| |. | .|. | ||.. .|| .|| .|.. | . |. .
pkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr.
gHKIivKFESTgKMKFEKNTdakiTETVFTV-EGPGGLA-QKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQ
.|| | ... .. ..|.. .. . | . | .| . || | . .|.||||| . . . .|. . |. | ||||||||||. . . ||. .
.fki..kiknk.elilnkki....skrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylare
LLGGQQIEETDkILQKIREQRNNSIQTDQQYLFV-----HQVILNYCLDKKMFD
.. ..|| |. |...||.| |..|| .| .. ...| .| .| |...
veadptielte.alkhlrehrwngvqtnsqlywmtlGtvyrlikeygfdmkiye
|
|||||||||
| subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 71-321 | 4.1e-48 | 158.5 | In-house | 46-293 (310) | alignment | ||
Range on Protein: 71-321
Range on HMM: 46-293/310.0
MKAFKeaQEHGKNRYKDVGCLDHNRVKLHP--PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFack
..|.| .. |||| || ||| ||||. .||||||.| | |||.| ||... ||| | .||. .||..||...|.| || |.
yeayk..kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw...
dkPVLEFEEKGHKIIVKFESTGKMKFE--KNTDAKITETVFTVEGPGGLAQ-KVTQYHWIDWPDRGVPTADMAIVE--LLAKTRpsKGPTVVHCSAGIGR
| | | | | | .|| . . . . . | | | | . .|. .| .||||||| | |||. | .|| |||||||..|
..pslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvr..hgpcvvhcsagkdr
TGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
.. || ... .|.| |.... .... ... .| |||. |||....| . .. .
lyvvvalklkidkldrglkvd.aeevktellksraiciqtelqyliidrvriifarge
|
|||||||||
| subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 75-318 | 9.5e-48 | 157.6 | In-house | 5-242 (250) | alignment | ||
Range on Protein: 75-318
Range on HMM: 5-242/250.0
KEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKkCCDYFackdkP
|. |.. |||| |. ||. || |.. ||| | |. . .. . || ||.|| .. ||| | |.||...| || |. |.. . . .|. |
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqyw.....P
VLEFEEKGHkIIVKFESTgkmkfEKNTDAKITETVFTVEGpGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-----KGPTVVHCSAGIGRTGS
| . |. |. . |. |. |. .| .... . . . . | |.|.. |||.||| |..||| | . | ..| .|.||||.||.|.
vekaekyGd.vtvsllsk.....eefadytkrklklskak.kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa
VVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
. |. .|..| .... |.....|..| ..... .|| ||...||..
fiaidavlerlkkekvvd.vfkvikvlrkdrphavesleqyvfvyeiilkal
|
|||||||||
| subfamily_PTPRK_pd | Subfamily PTPRK | 68-320 | 1.2e-47 | 157.3 | In-house | 32-279 (314) | alignment | ||
Range on Protein: 68-320
Range on HMM: 32-279/314.0
FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDY
|| | |. ... |||..|. |. ||.|.. ||| |... . .|. || || ||.. .||| . ..|. || || ...|.|. ||. |
fegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky
FACKDKpvLeFeekgHKIIVKFestgkmkFEKNTDAKITETVFTVEG---PGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK----TRPSKGPTVVHC
. . . . .| |.. | ...|.. .|.|| . ..| |.... ||| .||. ....|... . ...|..||||
WPedte..v.y....gdikvel.......vetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhC
SAGIGRTGSVVMIEYILDqLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
||| |||| ..|. .|| .. ... . .. ...|... | ..| .|| |...|||. ||
saGaGrtGtfiaidivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclc
|
|||||||||
| subfamily_PTPN13_pd | Subfamily PTPN13 | 56-316 | 5.3e-47 | 155.4 | In-house | 14-267 (273) | alignment | ||
Range on Protein: 56-316
Range on HMM: 14-267/273.0
RAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPhdYIHANFVSTPSNPRR--FICTQAPLDKSCADFWYMCLQEKVDSIFMLCNI
|| .. . .. . |..... ||||..| |. |||| . || |... | . . .| .| || ....||| | . |.. | |. .
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle
MEKGAKKCCDYFACKDKPVLEFEEKghkIIVKFESTgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTR---PSK
||| || |. . . | ... . |. . . .. |. .. . | ...|.. ....||| |||.. . .....|. | ..
kekgkvkchrywPesknkklkvsnr...levellkv......qkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda
GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILN
|| ||||||||||.|... |. .|. . .... .|..|.||||. .||..||.||...||.
gPivvhcsaGiGrsGtlitidvvlglierdkefd.vkeivrklreqrqgvvqtkdqyifvykaile
|
|||||||||
| subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 75-319 | 6e-47 | 154.9 | In-house | 16-265 (270) | alignment | ||
Range on Protein: 75-319
Range on HMM: 16-265/270.0
KEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVS-TPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdk
. |... |||.|. . ||.|.. || ||.| ......|....||. . .|| | ..||| .| |. ...||| ||| |..
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa...
pvlefeEKGHKIIVKFESTGKMKFEKNTDAKITETVFTVEgPGGLAQKVTQYHWIDWPDRGVPTADM------AIVELLAKTR-----PSKG-PTVVHCS
|...|. ... .. ... . | ..| | .... ... .|||.|||... ....|.. | .|. |..||||
......epkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs
AGIGRTGSVVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
||.|||| ........ | .. .. .|....|..| . .|. .|| |.......|.
aGvgRtGtlialDiavrlLee.tkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
|
|||||||||
| subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 39-318 | 3.1e-46 | 152.5 | In-house | 6-283 (290) | alignment | ||
Range on Protein: 39-318
Range on HMM: 6-283/290.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWPH-----DYIHANFVSTPSNPRRFICTQAPLDKSCA
. .|| | || | |..| ... .. .... ... .||.... | ||. |.| | .||.| .. .. ...| ||.|. . .
kfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlv
DFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVleFEEKGHKIivkfestgkmKFEKNTDaKITETVFTVEGPG--GLAQKVTQYHWIDWPDRG
||| . |||| | ||.||.|.| .|| |.. .| ..| |. |.... ...|. . |. | .|.||||. |.. |
dFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikl..........lneetln.eyierklevknknsagakqsvtqyqitnwdstg
----VPTADMAIVELLA-KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
| ..| | . .. ... |||||...||.. . .. ... ..|. ..|.. | |. .|.|| ||| ...|..|.|
kvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvid.vfqvlksqRiqkpgsvqtvqqyqgifqivltyl
|
|||||||||
| 0041856 | (Phosphotyrosine protein) phosphatases II | 81-322 | 1.4e-45 | 150.5 | In-house | 3-175 (182) | alignment | ||
Range on Protein: 81-322
Range on HMM: 3-175/182.0
GKNRYKDVGCLDHNRvklhppwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCnimekgakkCCDYFAckdkpvlefeekgh
||||.|. . ||.| . |||.||.. . ..|||.||.||....|||. | .... .| .|. .. |..
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..............
kiivkfestgkmkfekntdakitetvftvegpGGLAQKVTQYHWIDWPDRGVPTaDMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQllgg
| . ..||... ||| |||. ..... . . ..||..||||||.||||..|.. ... .
................................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl....
qQiEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
. ..... .|..|.....| .|| |.....| ..| ||
.g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
|
|||||||||
| 0051429 | (Phosphotyrosine protein) phosphatases II | 105-332 | 2.9e-45 | 150.3 | In-house | 5-239 (272) | alignment | ||
Range on Protein: 105-332
Range on HMM: 5-239/272.0
DYIHANFVSTPSN---PRRFICTQAPLDKSCADFWYMcLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEK-GHKIIVKFESTGKMKFEKNTDA
.||.|..|... . |.|......||. ..||||.. ......|..|.. .|.|. || | . . .| ... | . . . ...| .|
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy
KITETVFTVEGPGGLAQKVTQYHWIDWPDRGVP-TADMAIVELLAKtrpsKGPTVVHCSAGIGRTGSVVMIEYILdQLLGGQQIEE--------TDKILQ
..| . | . . | | .|...|..||||.||| | ...|||.. .|| .||||||..||| ||.. ..| . .. ..| . .....
ilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeave
KIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKLAH
..|.|| ...||..||||.....|.. .... ||.
elraqrpgavqteeqylflyeallellrsllsvraeyllaa
|
|||||||||
| subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 58-322 | 9.2e-45 | 147.5 | In-house | 16-273 (281) | alignment | ||
Range on Protein: 58-322
Range on HMM: 16-273/281.0
EFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPWP----HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNI
||. . . .|.. . |||| .. ||| ||.|. | ||||||.. .| | .| || | .. |||| | ||. .| |||..
efsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqf
MEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMKfekntDAKITETVFTVEGPgglAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKGPT
.| .||..|| . . .|.|. |. |..| . | | .. || .. .|.. | .||| || . ....| | | |
letnrekcaeyfprnahcclqfd....klsvsyedstvnk.....slvttrlnlsyege...trlithwlwkewpdwqvpessevmlkilrkirarstpp
VVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIRE-QRNNSIQTDQQYLFVHQVILNYCLDKK
|.|||||.||.|... .| |. . . . .|. ..| | |.|| |||... .|.|.. . |
vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvayk
|
|||||||||
| subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 41-341 | 1.1e-44 | 147.5 | In-house | 7-298 (312) | alignment | ||
Range on Protein: 41-341
Range on HMM: 7-298/312.0
VKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEhgKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCL
|. . | | |. |. . || .. ||| .. | | | | ||||||| ..| ||.|||.||...|. || ..|
kkwasavmmstpqqltkeykavgnivsdsectaflkfkd..lnrypniqcwdrgrftlagd.enfyihanfvkictkperfvctqgplentcthfwqlal
QEKVDSIFMLCNIMEKGAKKCCDYFACKdKPVLEFEEkgHKiiVKFESTGKMKFEKNTDAKITETVFTV-EGPGGLAQKVTQYHWIDWPDRGVPTADMAI
|| .|| ..| |..||. | . ...|. |. | |. ... .. ||| |. | | |. .| | ||| |.| . .
slgstsiillcgfvedgsekcakyisdi.vgfvdled..hr..vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdta
VELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDVDVKlAHLAFTEKY
||. . | | . |||||.||||....|| .. | .. . ... .| .| |... ||... ...|.. | .. . . . | | |
lrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqn.vkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneq.ewtkfkety
MK
|
ak
|
|||||||||
| subfamily_PTPRA_pd | Subfamily PTPRA | 56-326 | 9.8e-44 | 144.6 | In-house | 35-304 (330) | alignment | ||
Range on Protein: 56-326
Range on HMM: 35-304/330.0
RAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCN
| || |. . ... .. ... |||. .. |..|| | . ||| | |. . .|| .| |.... ||| | . | .| || .
reefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlte
IMEKGAKKCCDYFAckDKPVLEFEEkghkIIVKFESTGKMKFEKNTDAKITetVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRP----
. |. .|| |. |. .. . . | |. | . .. . .. . . .. |.|.|. ||| |||. . ...||.| .
lkerkeekcaqywP..deGlvtyGn....irvevedetvlvdytvrkflvq..qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqq
SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK-MFDV
| || |||||||.||||. .... .|... .... ......| || . .|||.|| |...|.|.| | .||
sagpivvhcsaGvGrtGtfivldavlervkaerkvd.vfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldv
|
|||||||||
| subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 38-318 | 3.3e-43 | 142.7 | In-house | 5-278 (287) | alignment | ||
Range on Protein: 38-318
Range on HMM: 5-278/287.0
KQIVKFVKNALEKGPAGLRAEFAAMKRFNDFE-KMKAFKEAQEHGKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFW
... .||.. .|| | . |. ... .. | .. | . |||.... | .|| |. .||| | |. . .. ..|| ...|. . .||
ekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiaesPmfntarnfW
YMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvLEFEEkgHKIIVKFEStgkmkfeKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRG-VPTA
. ...| | |||. .|. ..| .|.. .. . . | ..| . | .|.. . . . .. | |.|.||. .|...| |..
kliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGe..yniellnee.......vnagyierklevknknkagdkqqvkqyqitnWdstgkvtep
--DMAIVELLAKT--RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
. ..| || ...... |||||...||.. . .. ... |. ..|.. | |. .|.|| .|| |. ...|.|
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviD.vfqvlksqriqkpgsvqtveqykfindivleyl
|
|||||||||
| subfamily_PTPN23_pd | Subfamily PTPN23 | 45-318 | 5.5e-43 | 141.8 | In-house | 7-280 (288) | alignment | ||
Range on Protein: 45-318
Range on HMM: 7-280/288.0
KNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEA--QEHGKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVS--TPSNPrRFICTQAPLDKSCADFWYMCL
... .| ..| ..|. ... .| | | . |||..|. |||||||. ||| | || .| | ||.|||||... .||| |
qrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvy
QEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghkiivkfeSTGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIV
..|. | || . |.| .|. |. . .|.. . .| ...|. . .. . ..|. .. ||. ||| . ..
eqkssviVmllskeelgkpkvdrYwPedkgetvkfgd..........lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetll
ELLA--------KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
..| . |.|| | |||||||.|||| . .. .. .| |. . .. ......|||| ...|. .|. |. ...|..
qfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
|
|||||||||
| subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 55-318 | 5.9e-43 | 141.9 | In-house | 7-268 (274) | alignment | ||
Range on Protein: 55-318
Range on HMM: 7-268/274.0
LRAEFAAMKRFNDFEKMKAFKeaqEHGKNRYKDVGCLDHNRVKLHPPWPH----DYIHANFVSTPSN-PRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
|..|| . | |... |. .. |||||.. .. || |.. .. .|| ||.. ... . .. || || . |||| | ||.|. | |
lekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm
LCNIMEKGAKKCCDYFAckDKPVLEFEEKGHKIIVKFESTgkmkfEKNTDAKITETVFTVEGPgglAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS
| .. |. .|| || |. .| .|. .. .|.|.. .. | .... | ..|. | . ||||. .| ....|..... |
ltklkeaneqkCavyfP..daedyeiserygdveikveki.....verndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvlevees
-------KGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
.|.|||||||||||| . |. . || . .. || ..| .| .||..|| ..|... |
reeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralclyl
|
|||||||||
| subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 68-322 | 4.2e-42 | 139.1 | In-house | 33-281 (315) | alignment | ||
Range on Protein: 68-322
Range on HMM: 33-281/315.0
FEKMKAFKEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDY
. .. .| ... |||||.. ||..|||| .||| | .. . . . .|..|.||. | ||| | ||||| .| |. . | || |
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy
FACKDKPVLEFEEkghkIIVKfestgKMKFEKNTDAKITETvftVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKG----PTVVHCSAG
. .. || . | |. .. | .||. . . | . ..|||... .|||.||. ....|. . . ..| . .||||||
wPdrkadsvefGs....ikve.....llsleadtdgvarkl...vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaG
IGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
.|||| |. |. ...|. .. .. ......|..| .||...| |.....|.. | ..
vGrtGvvisidevvaqikrtrsvd.vfnfvknlrakrpylvqteeeyafiydavledllwrn
|
|||||||||
| subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 75-320 | 6.7e-42 | 138.2 | In-house | 39-278 (515) | alignment | ||
Range on Protein: 75-320
Range on HMM: 39-278/515.0
KEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKP
.| .. |||||.. .| .|||| . .||. | .. . | . .|..|.|.. | ||| . |||.| | |. . | || |. |
qeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd
VLEFEEkghkIIVKFESTgkmkfEKNTDAkITETVFTVEGPGglAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKG----PTVVHCSAGIGRTGSV
..| . | |. |. | |.. | .. . | .. |||.|. .|||.||| ... |. . . ..| | ..|||||.|||| |
svkfGs....ikvelvsl.....eactgg.ikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvv
VMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
. |. .. . .. .. .....||..| .||..|| |.....|.. |
isidsvvahakttrmvd.vfnfvtnirqkrpylvqtqeqyafiygavledllw
|
|||||||||
| subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 43-316 | 1.4e-40 | 134.2 | In-house | 14-277 (315) | alignment | ||
Range on Protein: 43-316
Range on HMM: 14-277/315.0
FVKNALEKGPAGLRAEFAAMKRfNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMC
.| . |.. .. .. .. .. |. ... |||| .. |. ||.| ||. |||. . .||.|..|.|. | ||| .
yvaqkkastkngfkqdyesipg.gqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlv
LQEKVDSIFMLCNIMEKGAKKCCDYFACKdkpvlefeekgHKIIVKFESTgKMKFEKNTDAKItETVFTVEgpGGLAQKVTQYHWIDWPDRGVPTADMAI
.|.. | || |..|. .|. |. | . | |. | ... |.||. . |. .| | ..| |.|. ||| ||| ...
feedigkivmltnlvegekrkaekywpdk...........kviyGkitvt.rkseevnteytv.rtlsvvf..gdnirevvqlhytswpdmgvpkytipl
VELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILN
..| . | |. |||||||.||||. . .. .|||. . |. ......|..| . .|. .|| |.....|.
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvy.nfitgvrqnrikmvqvaeqyqfiydalle
|
|||||||||
| 0046846 | (Phosphotyrosine protein) phosphatases II | 97-317 | 3.4e-40 | 133.0 | In-house | 5-172 (176) | alignment | ||
Range on Protein: 97-317
Range on HMM: 5-172/176.0
KLHPPWPHDYIHANFVSTPsnprRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdkpvleFEEKGHkiivkfestgkmkfek
.|..... |||.||.. .. |.|.||.|| ...|||. | ...... ...|.. .|.| ||..|. .|. |.
llgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.......leklgi................
ntdakitetvftvegpgglaqkvtQYHWIDWPDRGVPTAD--MAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllggQQIEETDKILQKIR
||....||| |||. . . ..|.. . . ..||..||||||||||| .|.. . .. ...|...|
........................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvr
EQRN-NSIQTDQQYLFVHQVILNY
||| ...||..|| |.....| .
eqRplgavqtpeQyrflyefelll
|
|||||||||
| 0043147 | (Phosphotyrosine protein) phosphatases II | 104-312 | 2.1e-39 | 130.3 | In-house | 5-155 (172) | alignment | ||
Range on Protein: 104-312
Range on HMM: 5-155/172.0
HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNImekgakkccdyfackdkpvlefeekghkiivkfestgkmkfekntdakit
.|||.|...... |.|||.||.||. .|||| |. ..... |..|..
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................
etvftVEGPGGLAQKVTQYHWIDWPDRGVPtADMAIV---ELLAK--TRPSKGPTVVHCSAGIGRTGSVVMIEYILdqllG-GqqieETDKILQKIREQR
. | .| . . ||... ||| ||| . |.. . . ..||..||||||.|||| .|.. ..| ..... .||.|
.....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl....sleeavalvrekR
NNSIQTDQQYLFVHQ
....|...|| |...
pgavqnpsqyrflyy
|
|||||||||
| subfamily_PTPN14_pd | Subfamily PTPN14 | 37-318 | 2.5e-39 | 130.1 | In-house | 9-296 (300) | alignment | ||
Range on Protein: 37-318
Range on HMM: 9-296/300.0
RKQIVKFVKNALEKGPagLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPW--PHDYIHANFVSTP--SNPRRFICTQAPLDKSC
. . .| ... ||.| . .|. ... . .... | .. |||.||| ..|||.| | ..|| | .... .. | .| .|.||.. .
kdkrakilekkleegk..vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltv
ADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIvkfestgkMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGV
||| | ...|. | || .. |.| .|. || ... . | . .|.. || ...|. || .. | . ..| ..||||.||
qdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvt........tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgv
PTADMAIVELLAKT----------R---PSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
| .. | . . || | .||||||.|||| ... . .. | ...|. .|.|...|||| .|| || ||..|...|
PeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeid.ikkvlarLreqrmllvqtlaqYkfvYkvlikyl
|
|||||||||
| 0036282 | (Phosphotyrosine protein) phosphatases II | 104-312 | 2.5e-39 | 130.1 | In-house | 2-164 (174) | alignment | ||
Range on Protein: 104-312
Range on HMM: 2-164/174.0
HDYIHANFVSTPSNPRRFICTQAPLDkscadFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACkdkpvlefeekghkiivkfestgkmkfekntdakit
.|||.|.... ..|.|..|.||. ||.|. .... ...||.. .|.| ||..|.
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................
etvftveGPGGLAQKVTQYHWIDWPDRGVPTADMaIVELLAKTRPS-----KGPTVVHCSAGIGRTGSVVMIEYILDQLLggQQIEETDKILQKIREQRN
. | . . ||... |||.|||. .. . |.. . .||..||||||.|||| .|.. ..| .|| . .. ......| ||
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrp
NSIQTDQQYLFVHQ
...||..|| |...
gmvqtpsQyrflyy
|
|||||||||
| subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 79-315 | 2.6e-39 | 129.9 | In-house | 3-236 (237) | alignment | ||
Range on Protein: 79-315
Range on HMM: 3-236/237.0
EHGKNRYKDVGCLDHNRVKLHPPW-PHDYIHANFVST-PSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVlefe
.. |||| .. . ||.|| |. . ||| |... |...|..| ||. || ||| | ||| | || ..|. .|| .|. |.|
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa....
EKGHkIIVKFestgkMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELL----AKTR--PSKGPTVVHCSAGIGRTGSVVMI
| . | . | |. .| . . .... . . ||.. ||||||| |.. . ... . || ..|||||.|||| ...|
aygv.ltvsl.....kkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvi
EYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVIL
. .| | ... . . .. | |.| ||| .||.|.||.||
damlrqake.kkvvdiynyvysieedrpyiiqtkdqyvfihqtil
|
|||||||||
| subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 78-321 | 3.2e-39 | 129.8 | In-house | 49-287 (297) | alignment | ||
Range on Protein: 78-321
Range on HMM: 49-287/297.0
Q-EHGKNRYKDVGCLDHNRVKLHPPWPH---DYIHANFVstPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNImEKGAKKCCDYFAckDKPVL
. . |.|||.. | .||||. . ||. | || ..| |.|.|| | . . |||| | |.|.| | || . ... ||| |.. || |
kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlndd.nerdkkcaryWs..dkgvt
EFeekGhKIIVKFESTGKMKfekntdAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTAD--MAIVELLAKTR-----PSKGPTVVHCSAGIGRTGS
.| | .. |. .|. . . | .. .| . | ||....|||. |. | ....|. | ..|| .|||.||.||||
tf...G.dvsvvllsvsere......GfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgv
VVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
.. |. .. . .... ....|.|..| . .||..|| ||....|.. | .
lltidsvvaeakrekevd.ifglvkklrqerpylvqtkeqykfvyvavleallse
|
|||||||||
| subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 51-319 | 1.1e-38 | 128.3 | In-house | 32-292 (319) | alignment | ||
Range on Protein: 51-319
Range on HMM: 32-292/319.0
GPAGLRAEFAAM-KRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPPW---PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDS
|..|| .. |. . ... |. |||. .. |.|.|||.. ||| | ||. .. ..| .| ||| . |||| | . .. .
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst
IFMLCnimekgAKKCCDYFACKdkpvleFEEKGHKIIVKFESTGKMKFekntdAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK-
| .| .||..|. | ..| . || .| . . . . . .| .|.||.|. ||| ||| . .. |. |
ivllt......kdkcsqywplk......ivikeerfkvkvdsveetae.....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkv
-----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
. . |||||||.|||| .... .||.. .|.. .... .|.|||. .| || |.. .|. |
rhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysalleehl
|
|||||||||
| subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 77-319 | 7.4e-38 | 125.7 | In-house | 23-256 (284) | alignment | ||
Range on Protein: 77-319
Range on HMM: 23-256/284.0
AQEHGKNRYKDVGCLDHNRVKLHPPWP---HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCnimekgAKKCCDYFACKDKpvl
|. |||. .. |.|.|||.. ||| | |.. .. ..| || ||| . |||| | . .. .| .| .||..|. | .
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv...
efeEKGHKIIVKFESTGKMKFekntdAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK------TRPSKGPTVVHCSAGIGRTGSV
.| .. || .| . . . . . .| .|..|.|. ||| ||| . .. |. | . . |||||||.||||
...ikeerfkvkvdsveesee.....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy
VMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCL
.... .||.. .|.. ......|.|||. .| || |.. .|. |
ivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysalleehl
|
|||||||||
| subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 78-316 | 1.7e-37 | 123.9 | In-house | 47-277 (439) | alignment | ||
Range on Protein: 78-316
Range on HMM: 47-277/439.0
QEHGKNRYKDVGCLDHNRVKL--HPPWPH-DYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAkkccdYFACKDKPVLe
.. |||||||| .|| || | | || || ||.. ... .| ||.| .... ||| . ...|. | ||.|..| |. .... .
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcy.
feekgHKIIVKFESTGKMkfekNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELL-----AKTRPSKGPTVVHCSAGIGRTGSVVM
|.|. . .. . || . . | |.|.| |||. ||. ....| |. . || |||||||.||||...
.....gdiavrvdrniel....pnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiia
IEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILN
.. |.|| .... . |.. .|.||.. .|. ||.|... .|.
ldialeqlklenkvd.ikgivkvlrkqrkqmvqalcqyvfiynavle
|
|||||||||
| 0049772 | (Phosphotyrosine protein) phosphatases II | 79-318 | 1.7e-36 | 121.9 | In-house | 46-280 (314) | alignment | ||
Range on Protein: 79-318
Range on HMM: 46-280/314.0
EHGKNRYKDVGCLDhNRVKLhPP---WPHDYIHANFVSTPsnpRRFICTQAPLDKSCADF----------WYMCL--QEKVDSIFM--------------
. ||||.|. . | |||.| | .|||.|..|... ..||.||.||. . || | | | . .| | |
nrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd
-------LCNIMEKGakkccDYFACKDKPVLEfeekghkiivkfestgkmkfE-------KntdakitetvftvegpgglAQKVTQYHWIDWPDRGVPTA
|......| .. .| . |. | . . .|..|..|| ..|.
aAlgKtpllildgng.....neptaadlellk....................eelydpelf...................erlgikylripvpDgsapll
DM--AIVELLAKTrPSKGPTVVHCSAGIGRTGSVVMIEYILDQLlggqQIeETDKILQKIREQRN-----NSIQTDQQYLFVHQVILNYC
.. ...|.. . . .||..|||.||.||||. | . |.. .| .. ...|. .|..| ..|.. .||.|.....|.|.
edfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleyl
|
|||||||||
| subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 71-327 | 2.4e-36 | 120.1 | In-house | 24-277 (283) | alignment | ||
Range on Protein: 71-327
Range on HMM: 24-277/283.0
MKAFKEA-QEHGKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVS---TPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFA
. | ... |||.... | .||.|.. ..||| | |. . ...| .|.|||. ||| | .||. .| || ...| .||. |.
dadiasadenkrknrnqeivpadqwrvelkse.srdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP
CKDkpVLEFEEkgHKIIVKFEsTGKMKFEKN-TDAKITetvftveGPGGLAQKVTQYHWIDWPDRGV--PTADMAIVELL--AKTRPSKGPTVVHCSAGI
. .. | . .. | |.. | . . . . .. | ||| . | . . .... .|. ||| |||||.||
krG..sedyGe..ftvtlrke.ttsnsfiikelllrvn.......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgi
GRTGSVVMIEYILDQLLGGqQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNY--CLDKKMFDVD
|||. . . ....| . . .... .|||| .|| .|| .||...|. | | .. ||
Grtavfiaasasvkdalte.svvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavd
|
|||||||||
| subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 81-321 | 3.3e-36 | 119.7 | In-house | 37-273 (285) | alignment | ||
Range on Protein: 81-321
Range on HMM: 37-273/285.0
GKNRYKDVGCLDHNRVKLHPpWPHDYIHANFVSTPSNP-RRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKG
||| || |.. || |. .|||||... | . .| || || .. .|||.| |||. ..||| ..| | .||. |. | |..| .
dlnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkye
HKII-VKFESTGKMKFEKNTdakITETVFTVEGPggLAQKVTQYHWidWPDRGVPTADMAIVELL---AKTRPSKGPTVVHCSAGIGRTGSVVMIEYILD
. .| |. .. | ...| . | | . | | |||. | ..|| | | . | .||||||.||| ..| |.|
itlteckeeaiagtilnalt...vintedassep..lymnhvqvpw..wpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyati
QLLGGQQIEETDkILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
... .|| | |....| | ...|. |.||.. |...| . .
rimenpniemld.ivremramrfqavqshmqflflyvvlmeyfige
|
|||||||||
| subfamily_PTPN9_pd | Subfamily PTPN9 | 39-248 | 9e-36 | 118.4 | In-house | 2-204 (297) | alignment | ||
Range on Protein: 39-248
Range on HMM: 2-204/297.0
QIVKFVKNALEKGPAGLRAEFAAMKRFNDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADF
.| ..|. ||| ||. |.|.... . ...|.| . ||||.|| |.|. ||.| |||.|||| ... || || ||.| . ||
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf
WYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghkIIVKfestgKMKFEKNTDakITETVFTVE-GPGGLAQKVTQYHWIDWPDRGVPT
| | ...| | | ..|.| || |. ... . || . . |. ... |.. | ...|.... . .||| . . ||| |||
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgd....lsvs.....nveveeeed..ykvrvleiknvkteesrkvthfqflsWPdyGvPs
ADMAIVELLAKTRP
. ......| | |
saaslldvlekvre
|
|||||||||
| subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 55-318 | 1.2e-35 | 117.6 | In-house | 17-293 (301) | alignment | ||
Range on Protein: 55-318
Range on HMM: 17-293/301.0
LRAEFAAMKRFNDFEKMKAFKEaQEHGKNRYKDVGCLDHNRVKLHPPWP-----HDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
. ... ..|. .| . . ..| ... ||.|.. .|.||. |.| ..|| |.... |. ..|| .|.|..| .||| . .|||. || |
feeqykelkegedksctvglse.enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivm
LCNIMEKGAKKCCDYFACKDKPVLEFEEkghkIIVKFEST----------GKMKFEKNTDAKITETVFTVEGPGgLAQKVTQYHWIDWPDRGV---P-TA
..| |. .|| |. .. || . . |.. .. ..| .. .. . .| | |. ...|.|.. .|||. || | |
vtnlkegtkskceqywpnseaeseefgp....ftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtv
DMAIVEL-LAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
..| . .. ....|| |||||....|.| . .. |.| . . . .. . .| .. ..| .|| ....|| |
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
|
|||||||||
| subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 48-322 | 2.7e-35 | 117.1 | In-house | 18-292 (325) | alignment | ||
Range on Protein: 48-322
Range on HMM: 18-292/325.0
LEKGPAGLRAEFAAMKRFNDFEKMKAFKeAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKv
. |. || . . | | | .. |||.|.| ||..|| | ||| |... . . |. .|||| .. |.| . |. .
kaqdqdgfahefgllpsddgiakkvamk.penkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.
DSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEekghKIIVKFESTGKMkfeknTDakITETVFTVEGP-GGLAQKVTQYHWIDWPDRGVPTADM---AIV
|. .. |....| ..|. |. . .| . ||. . .. .| |. | .. .| .. | |... |.| ||. .|.
csvvvvlneldlgkdrcavywpkemgksktfG....glevklrtieei.....sd..yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil
ELLA-------KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
.|. . .| .||||||.|||| . . .|.... ... . ..|.|..| . ..| || .... . .. . .
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdif.gfvkklrkdrpsmvetvdqyiliyealveaymsgn
|
|||||||||
| subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 56-318 | 1.3e-34 | 114.4 | In-house | 13-277 (287) | alignment | ||
Range on Protein: 56-318
Range on HMM: 13-277/287.0
RAEFAAMKRFNdfEKM-KAFKEAQE---HGKNRYKDVGCLDHNRVKL--HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
.|. |.|. | . ||.|.| |||| || .|..|| | .. ||| ||.|.. . .||..|.|. . ||| . |.... |. .
dkevdalkeds..esstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvit
LCNIMEKGAKKCCDYFACKDKPVLEFeekGHKIiVKFESTgkmkfEKNTDaKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIV----EL---
. .|.. .|| |. ...|.. |. . | .. . |. . . .. .. . |. | |.....|||.... . .... .
mtreveearlkcykywPerevPmrvG...Gysv.vlldyd.....ikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqh
--LAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
||. || |||...||||.| .. . ....|. ... . ... ..||.|. .|. |. .. . . |
ielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvd.vaavvirlreyraalvqavvqlrllyealvtyy
|
|||||||||
| 0049260 | (Phosphotyrosine protein) phosphatases II | 116-312 | 1.8e-34 | 114.0 | In-house | 6-144 (152) | alignment | ||
Range on Protein: 116-312
Range on HMM: 6-144/152.0
SNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFackdkpvlefeekghkiivkfestgkmkfekntdakitetvftvegpggl
.|..||.||.|.. ..|||| | . ... | ||.. .|.| || |.
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................
aqkvtQYHWIDWPDRGVPTADMAIVELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILdqllggqQIEETDKILQKIREQRNNSIQTDQQYLFVH
||... ||| |||. .. . .|| . ..||..||||||.|||| .|.. ..| . . ..... .||.|...... .|. |..
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
Q
.
e
|
|||||||||
| subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 53-321 | 3.8e-34 | 112.7 | In-house | 20-239 (392) | alignment | ||
Range on Protein: 53-321
Range on HMM: 20-239/392.0
AGLRAEFAAMKRFNDFEKMKAFKEaQEHGKNRYKDVGCLDHNRVKL---HPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFM
| . || . . ... | || . |||||.. .| .|||| .||. | .. . | . .|..|.| | ||| | .||.| .| |
alffeefhdlpgpdiypqtvaqke.inlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiam
LCNIMEKGakkccdyfackdkpvlefeekghkiivkfestgkmkfekntdakitetvftvegPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS
. .. | | |. |.|.|. .|||..|| ...... . .
vtklkegd......................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad
KG----PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
| | ..|||||.|||| |. |. .. . . . . ... .||..| .||..|| |.. .|. | .
fGqythpliihcsagvgrtgvvisidsvvahakktrmv.dvfnfvtnirrkrpymvqtkeqyafiygavledllwr
|
|||||||||
| subfamily_egg_pd | Subfamily egg | 66-320 | 3.4e-33 | 109.6 | In-house | 27-272 (307) | alignment | ||
Range on Protein: 66-320
Range on HMM: 27-272/307.0
NDFEKMKAFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKgaKKCC
| . .. .. . | | | | | | ||||. . . |.|||| |. ||..|||| . ||| | ||.|. | || | ..|
vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce
DYFACKDKPVLEFEEKGHKIivkfestGKMKFEKNTDAKITETVFTVEGPGGLAQKVTQYHWiDWPDRGVPTadmAIVELLAKTRPSKGPTVVHCSAGIG
|. .. | . . .| .| ....| . | . . |. . . . . |. . ...| | | |.||.. |.
yywpkaesdslvtvpGslri.......enlkvdskadplfrvtklklvGgddeerflehwqg.dvnnssdvy...splrvlrklrnlskpvvvqdilGvs
RTGSVVMIEYILDQLLGGQQIE-ETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
.....| || | .|| | . . .| .|. |... .||||....| . |
kaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
|
|||||||||
| subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 75-315 | 5.1e-33 | 109.2 | In-house | 4-238 (239) | alignment | ||
Range on Protein: 75-315
Range on HMM: 4-238/239.0
KEAQEHGKNRYKDVGCLDHNRVKLHP--PWPH-DYIHANFVST-PSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKdk
|. .. |||| .. ||.|| | || ||| |... .|. .|.|| . |. ||| | ||. | || ..| ||| .|.
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds..
pvlefEEKGHKIIVKFEstgkmKFEKNTDAKITETVFTVEGPgGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK----TRPSKGPTVVHCSAGIGRTGS
| .. | . | | .| | |.. | . | |||. |||.||| |.. | | . | | |.|||||.||||.
.....tskycnlrvtlr.....ktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtga
VVMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVIL
...|. .| | |. . . .. |||.| .|| .||.|.| .|
flvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavl
|
|||||||||
| subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 76-316 | 5.8e-33 | 109.0 | In-house | 4-238 (239) | alignment | ||
Range on Protein: 76-316
Range on HMM: 4-238/239.0
EAQEHGKNRYKDVGCLDHNRVKLHP--PWPH-DYIHANFVST-PSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKdkp
. .. |||| .. ||.|| | || ||| |... .|. .|.|| . |. ||| | ||. | || ..| ||| .|.
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds...
vlefEEKGHKIIVKFEstgkmKFEKNTDAKITETVFTVEGPgGLAQKVTQYHWIDWPDRGVPTADMAIVELLAK----TRPSKGPTVVHCSAGIGRTGSV
| .. | . | | .| | |.. | . | |||. |||.||| |.. | | . | | |.|||||.||||..
....tskycnlrvtlr.....ktevfadyiirtfvmsqvgq.teeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf
VMIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
..|. .| | |. . . .. |||.| .|| .||.|.| .|.
lvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavle
|
|||||||||
| 0044763 | (Phosphotyrosine protein) phosphatases II | 91-320 | 5.1e-30 | 99.8 | In-house | 2-173 (178) | alignment | ||
Range on Protein: 91-320
Range on HMM: 2-173/178.0
LDHNRVKLHPPWP---HDYIHANFVStpsnPRRFICTQAPldkscADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvlefeekghkiivkfe
||..||.|... |||.|... |. ..... | ||.. . ......| .|.. .| | ||. |. .
ldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................
stgkmkfekntdakitetvftvegpgglaqkvTQYHWIDWPDRGVPT---ADMAIVELLAKTR-PSKGPTVVHCSAGIGRTGSVVMIEYILDQllggqQI
||..| .|| |||. ...||.. . . ...||..||||||.||.|..|.. ... . ..
................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....gl
eETDKILQKIREQRNnSIQTDQQYLFVHQVILNYCLD
..... .||.|. .... |. ..... | ..
.sleeaielvrerRp.ivpnpgqlrqLyefelrllke
|
|||||||||
| subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 102-320 | 8.7e-30 | 98.8 | In-house | 44-261 (290) | alignment | ||
Range on Protein: 102-320
Range on HMM: 44-261/290.0
WPHDYIHANFVSTPSNpRRFICTQAPLDKS-------CADFWYMCLQEKVDSIFMLCNIMEKGAKKCCdyFACKDkpvleFEEKGHKIIVKFESTGKMKF
||||||.|. |.. |.| ||.|. | .||.| ||||... |||. .|| |.. |||. . . ..||.
fnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantsl..faCak.....YvpesvgeelkfkgltvkCk
EKNTDAKITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIR
.| .. . . .|. .. .|| . .| .. |. ...|. | . || | .||| || | . |. . . .. .. ..|...|
skekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalr
EQRNNSIQTDQQYLFVHQVILNYCLD
.||.. |...... || .|. . .
kqralaitsalelafvdagivllaie
|
|||||||||
| 0051082 | (Phosphotyrosine protein) phosphatases II | 104-314 | 3.3e-29 | 96.8 | In-house | 3-149 (151) | alignment | ||
Range on Protein: 104-314
Range on HMM: 3-149/151.0
HDYIHANFVSTPsnprrFICTQAPLDkscaDFWYMCLQEKVDSIFMLCNIMEKGakKCCDYFACKDkpvlefeekghkiivkfestgkmkfekntdakit
|||....| ......||. ||. . ......|..|.. .| | .| .|. .
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................
etvftvegpgglaQKVTQYHWIDWPDRGVPTADMAIVELLAKTRPS-KGPTVVHCSAGIGRTGSVVMIEYILDQllggqqiEETDKILQKIREQRNNSIQ
.|......|||| |.|. |..|.| . . .||..||||||.|||| .|.. .| . ...|. .|..| ...|
.............ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvq
TDQQYLFVHQVI
. ||.||.....
pnqqflfqlfal
|
|||||||||
| PTPc_DSPc_SM00012 | 218-315 | 4.2e-29 | 96.2 | In-house | 1-104 (105) | alignment | |||
Range on Protein: 218-315
Range on HMM: 1-104/105.0
KVTQYHWIDWPDRGVPTADMAIVELLAKTRPSKG------PTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVH
.|..||. .||| |||. .|.|||.... .| |.|||||||.|||| .|.....|.|| ... . .|....|.||....||..||||..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly
QVIL
...|
rall
|
|||||||||
| subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 39-321 | 6.6e-28 | 92.0 | In-house | 15-288 (302) | alignment | ||
Range on Protein: 39-321
Range on HMM: 15-288/302.0
QIVKFVKNaleKGPAGLRAEFAAMKRF-NDFEKMKAFKEAQEhgKNRYKDVGCLDHNRVKLHpPWPHDYIHANFVSTPSNPRRFICTQAPLDKSC---AD
. .|.||. | ...|| ... . | || ||||. . ||. .|| .||.|.|||. | .|..| |. |. | | .| | .| ..
eakklvks...ldtaevkkefkkidtmkvdlekCkafkknlk..knqsedvpildsnlvkle.aepdsyvnaskvevPeltrsiilaQlpkvdsedsvee
FWYMCLQEKVDSIFMLcnIMEKGAKKCCDYFACKDKPvlEFEEKGhKIIVKfestgKMKFEKNTDAKiteTVFTVE-GPGGLAQKV--TQYHWIDWPDRG
|| | |||. |...| ..|. || . . .| ...| | |. | . | || ..| | ...| | | .. | . |. |..
FWrmvfqekivsvvil..vgeeelkktlselfpkksg..dykeyg.kmfvN.....nrkVekaeeek...tryviEvlPegcsnsvlanvyvltnWkqkk
VPTADMAIVELL----AKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIeETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
||. .... ||. ... .||. |.|| |... ...| |.. . |...||.|| ..... .|| ... ..| | . |
vpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkep.nikeivksiRsqRpravdslkQyvslyialllyikkk
|
|||||||||
| subfamily_CG7180_pd | Subfamily CG7180 | 70-320 | 2.2e-26 | 87.2 | In-house | 33-292 (296) | alignment | ||
Range on Protein: 70-320
Range on HMM: 33-292/296.0
KMKAFKEAQEHGKNRYKDVGCLDHNRVK---LHPPWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAkKCCDYFA
. .. ... .|||. .| |.||| |. ||| | .| . .. .| |.|| ... .|| . .|..... .|.. .. .. .|.
dCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywp
CKDkpvlefEEKGHKIIVKFESTGKMKFEKNTDAKITETVF-TVE---GPGGLAQKVTQYHWIDWPD-RGVPTADMAIVELLAK-------T--RPSKGP
| .|. .|.|. .. .. | |.| .. . | . |..... |. || |..||. . . .| .||
nks......keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegP
TVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
.||..| | .|.| . |. |... .... . ....|..|.. ... ..| .. .|.|.. |
vvvvssdGasRsGvylaidanlelvekeeevdvF.eavktlrrsRpqLvenveeYkyiYdvlleavlc
|
|||||||||
| subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 74-235 | 1.1e-24 | 81.9 | In-house | 25-182 (297) | alignment | ||
Range on Protein: 74-235
Range on HMM: 25-182/297.0
FKEAQE---HGKNRYKDVGCLDHNRVKLHPPW-PHDYIHANFVSTPSNPR--RFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAC
| |. ||||.|. | .|||| .||| |..| | .. ..|..| ||... ||| . .. | | |.... | | .|| |.
fssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps
KDKPvlefEEKGHKIIVKFESTGKMKFEKntdAKITETVFTVEgpgGLAQKVTQYHWIDWPDRGVPTA
.. | ...|.| |. .|.. ..|| . ..|. .. ||| |||.
vvqe....rlkagdvvveflsstsdefdr...viltelqliyr...sesrvvrhvqflswpdhGvpsd
|
|||||||||
| subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 55-318 | 2.2e-24 | 80.9 | In-house | 8-259 (267) | alignment | ||
Range on Protein: 55-318
Range on HMM: 8-259/267.0
LRAEFAAMKRFNDFEKM-KAFKEAQEHGKNRYKDVGCLDHNRVKLHPPwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNI
.. || .|. | . . . . .||. |. |..|| | ..|| | .| . . || || ||... .||. . ..|| | .| ..
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv
MEKGAKKccdYFackdKPVLEFEEKGHKIIVKFeStgkMKFEKNTDAKI-TETVFTVEGpgglAQKVTQYHWIDWPDRGVPTAD-MAIVELLAKTRPSKG
. .. .. | . .| . . |.. | .. |.| | | | | |..|| |.. | .. .||| . .|
ftdnirl...fw....PPkmgqakkyqdltveh.s...lekeendyqiitlelkfknes....ahnvtlyyykkwnintnnkpylkplfgilaknqleng
--PTVVHCSAGIGRTGSVVMIEYILDQLLgGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
| ||.||.|.||.|. ..|. |... ... . . |.|||.|| ..| ..|...|... .|
nrPlvvacsdGvGrsGtflvidsqlerak.tegvsdifdflrkirsqriglvdtkeryiyihellaeya
|
|||||||||
| subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 78-326 | 2.9e-24 | 80.2 | In-house | 46-287 (303) | alignment | ||
Range on Protein: 78-326
Range on HMM: 46-287/303.0
QEHGKNRYKDVGCLDHNRVKLHPpwpHDYIHANFVSTPSNpRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKgAKKCCDYFACKDKPVLEFEE
.. |||. || |||| .||| ||||... |. .. | || || ...|||| | ...|| ...| | | |. ... |.|||
knmdknrfvdvicldhskvklsd...ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdsey.dklggdsvfprnqdflkfee
KGHKIivkfestGKMKFEKNTDAKITEtVFTVEgPGGLAQKVTQYHWIDWPDRGVPTAD-----M---AIVELLAKTRPSKgPTVVHCSAGIGRTGSVVM
. .. |..| . .| | .| | . .|. .|| .|. . .| | .|. ||| .| ||.|. .
rsirv.......gefkrvelgdgwvlk.vlsvs.ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfal
IEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMFDV
.| | | . | |...|. | ..| |. .|. .. .. ||. . .
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngickl
|
|||||||||
| subfamily_Cele-PTP-7_pd | Subfamily Cele-PTP-7 | 127-320 | 1.1e-23 | 78.2 | In-house | 99-290 (302) | alignment | ||
Range on Protein: 127-320
Range on HMM: 99-290/302.0
PLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEKGHKIIvkfeSTgKMKFEKNTDAKiTETVFTVEGPGG-----LAQKVTQ
| ... .| . | .| . ||...|.. ||| .|.. | . .|.| . | . | | ..|. || | . ...||| . . |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktv....sv.ktdleeftdkk.sfklytveiknekkkkkvkktvdi
YHWIDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILdQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLD
.. ||| | | . ...| | .||||||.||||..| | | . || ... . .|.. .|. | ..|..|| ... .. ..
lafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme
|
|||||||||
| 0048076 | (Phosphotyrosine protein) phosphatases II | 202-316 | 1.2e-22 | 75.5 | In-house | 30-141 (145) | alignment | ||
Range on Protein: 202-316
Range on HMM: 30-141/145.0
ITETVFTVEGPGGLAQKVTQYHWIDWPDRGVPTA---DMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllggQQiEETDKILQKIREQRN
|| . . .| ....||....|||.|||. ....|.. . ....||..||||||.||||..|.. .| .. ...|...|.||
ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleealelvrsqrp
NSIQTDQQYLFVHQVILN
.......|. |.....|
gavpnpgqlrflyefele
|
|||||||||
| subfamily_ptpA1_pd | Subfamily ptpA1 | 78-270 | 3.1e-21 | 70.6 | In-house | 46-249 (418) | alignment | ||
Range on Protein: 78-270
Range on HMM: 46-249/418.0
QEHGKNRYKDVGCLDHNRVKLHP---PWPHDYIHANFVSTpSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKD-KPVL
.. |||| .. ..| ||.|. ||| ||.. . |..||||| || .. |||| | .... | || |. || |. . .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf
EFEEKGHKIIVKFeSTGKMKFEKNTDAKI-TETV-FTVEGpggLAQKVTQYHWIDWPDRGVPTADMAIVELLAK-------TRPS---KGPTVVHCSAGI
.| ... . | .. .. . .| | . .|.|| .. .|||.. |||. .| . .|| || . | .||||||.
siygngnevfgty.svelveviqdpereiitrnirltfeg...etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv
GRTGSVVMI
||||...
grtgtfcta
|
|||||||||
| 0048179 | (Phosphotyrosine protein) phosphatases II | 175-312 | 3.4e-21 | 70.9 | In-house | 25-139 (144) | alignment | ||
Range on Protein: 175-312
Range on HMM: 25-139/144.0
FEEKGHKIIVKFESTGKMKFEKNTdakitetvftvegpgglaqkVTQYHWIDWPDRGVPTA---DMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIE
. . |.. .. . .. . |.... ..||....|||.|||. ...|.. . ....||..||||||.||||..|..
lkklgittvinlteeyepeflere....................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay
YILdqllgGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQ
.. .. ...|. .|..| .......|. |...
lmk.....klg.lsleealalvrsrrpgavpnpgqlrfLle
|
|||||||||
| subfamily_Cele-PTP-9_pd | Subfamily Cele-PTP-9 | 131-325 | 9.5e-20 | 65.7 | In-house | 40-228 (255) | alignment | ||
Range on Protein: 131-325
Range on HMM: 40-228/255.0
SCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKPVLEFEEkghkiiVKFESTGkmkfeKNTDAK-ITETVFTVEGPGGLAQKVTQYHWIDWPD
. . |. . | | . . |||. |.| .|| || . | ... |. .| .| | .. . | ...|. |.. |..
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad......vnvtttk.....ssadvvlrtleitstlgekkkthtvkhysykGWie
RGVPTADMAIVELLAKTRPSKgPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETD-----KILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKMF
. | | ..| | || . |||||.||||. . |..|.. ... . || ..|...|..|. .|.| | | ..|.. |. .
knaPelareilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgel
D
.
e
|
|||||||||
| subfamily_PTPN9_pd | Subfamily PTPN9 | 245-322 | 1.4e-19 | 65.3 | In-house | 218-294 (297) | alignment | ||
Range on Protein: 245-322
Range on HMM: 218-294/297.0
KTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKK
| .||. | |||||||||||| . ... |..| .... . ....|.|| ||||..|| | .. .|.| | .|
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvd.vvetvkllrtqrafsiqtpeqyefcylavleyalelk
|
|||||||||
| subfamily_PTPRN_pd | Subfamily PTPRN | 217-314 | 3e-18 | 60.6 | In-house | 187-288 (297) | alignment | ||
Range on Protein: 217-314
Range on HMM: 187-288/297.0
QKVTQYHWIDWPDRGVPTADMAIVELLAKT----RPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQ
. |||.|.. ||..|||.. ...|. | | | |||||.| |||| ..|. .|..|| | . . |...|.||.. ..| .|. |. .
rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
VI
..
av
|
|||||||||
| subfamily_CG42327_pd | Subfamily CG42327 | 104-249 | 1.2e-17 | 58.6 | In-house | 56-193 (319) | alignment | ||
Range on Protein: 104-249
Range on HMM: 56-193/319.0
HDYIHANFVSTP-SNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFACKDKpvlefeEKGHKIIVKFESTGKMKFEKntDAKI
|..|..| . . | .|..|..|..| .||| . . . | |... |.| |.| .|. |. .... .. | | . | | .
deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket......ldntslyGdilvtlkgrevk..drya
TETVFTVEGPGGLAQKVTQYHWiDWPDRGVPTADMAIVELLAKTRPS
. |. . . .....| | . .|.. .||. . |.. .| ..| |
istlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
|
|||||||||
| subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 33-166 | 1.6e-17 | 58.3 | In-house | 8-151 (350) | alignment | ||
Range on Protein: 33-166
Range on HMM: 8-151/350.0
KKTHRKQIvkFVKNALEKGPAGLRAEFAamKRFNDFEKMKAfkeAQEHGKNRYKDVGCLDHNRVKLH-----------PPWPHDYIHANFVSTP-----S
|... | | . ||. | . | .. ||.. . . |||||.. .|.||||. . ||| ||... .
krsklkli..itknstvksrlsLesdse..spsnDvilseG...velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsvei
NPR-RFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFA
|| ..| ||||| . ||. ..|. || | .| . .| . .|| |.
npdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWq
|
|||||||||
| subfamily_hpo-7_pd | Subfamily hpo-7 | 130-321 | 4.5e-17 | 56.8 | In-house | 45-230 (263) | alignment | ||
Range on Protein: 130-321
Range on HMM: 45-230/263.0
KSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAckdkpvLEFEEKGHKIIVKFESTGKMKfekNTDAKITETVFTVEGpGGLAQKVTQYHWIDWPD
. . |. . | | . . |||. |.| .|| || || .|| |. .| .. .. | | . |.. ..|..| . |..
qtidkfyqtivqtktevvvmLcDfneegvekcssyfP......lekdekqklanvnvcttkvqs...dvllktlellstlge.KkkthtvkhysykgWie
RGVPTADMAIVELLAKTRPSKgPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETD-----KILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
. |. |...| .| || . |||||.||||. . ...| . ... . .| ..|...|..|. .|.| | | ..|.. |.
kndpelareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn
|
|||||||||
| subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 217-323 | 6.1e-17 | 56.1 | In-house | 89-201 (440) | alignment | ||
Range on Protein: 217-323
Range on HMM: 89-201/440.0
QKVTQYHWIDWPDRGVPTADMAIVELLAK-----TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETdKILQKIREQRNNSIQTDQQYLFVH
. . |||. |||.||| ..... . ..|| .|||||| |||| .. .. || . .||. ... .|..| . .|| .|| |||
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidif.sfinsmrnnrpqmvqtpeqyafvh
QVILNY--CLDKKM
...|. | | .
eavlegllcgdtli
|
|||||||||
| subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 240-316 | 1.5e-16 | 55.2 | In-house | 218-293 (297) | alignment | ||
Range on Protein: 240-316
Range on HMM: 218-293/297.0
VELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLlGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILN
.| | | . ...||||||.||.| ||. . ||..| ..| .. ||...|||| .|| .|. ......|.
leslraemprnayllvhcsaGvGrsGvvvlsdvilakl.rkkripdvaailsilreqrarlvqtleqfellydavlk
|
|||||||||
| subfamily_PTPRN_pd | Subfamily PTPRN | 40-167 | 1.4e-15 | 51.8 | In-house | 17-148 (297) | alignment | ||
Range on Protein: 40-167
Range on HMM: 17-148/297.0
IVKFVKNALEKgPAGLRAEFAAMKRFNDFEKMK-AFKEAQEHGKNRYKDVGCLDHNRVKLHPP---WPHDYIHANFVSTpSNPRR--FICTQAPLDKSCA
....... |.. . |..|. |..... .. | . |. . |||.|.| ||.||||. .||| | .. ..||. .| ||.|| .. |
vlsyledhlkn.kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaild.hdprapayiatqgplastva
DFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYFAC
||| | .. | | .|... |.| |.| |.
dfwqmvweqGvvvivnltrleeegvkqckrywpd
|
|||||||||
| subfamily_eak_pd | Subfamily eak | 64-323 | 1.6e-14 | 48.1 | In-house | 34-310 (332) | alignment | ||
Range on Protein: 64-323
Range on HMM: 34-310/332.0
RFNDFEKMKAFKEAQEH---GKNRYKDVgCLDHNRVKLHPPW--PHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGA
..|...... .|.. .| .| | |.. |.| . . || | . . |..| | .. .. || | |..| .| .| . .|..
dlddyqrllsisetarleavnrnvvkiv.pydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkl
KKCCDYFACKDKPVLEFEEK--GHKIIVKFESTGKMKFEKNTDAKIT-ETVFTVEGPGGLAQKVTQYHW-I--DWPDRGVPTADMA-------IVELLAK
.| || | . .|.| | || . ..| . . ..| | .. . . . . ||. .. .
eksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyih
TRPSKGPtVVHCSAGIGRTGSVVMIEyILDQLLGGQQIE--ETDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDKKM
| || | .. .. | |.| |.|. .| .|. ... . .... |....|. |. ...|. |.....|.| | ..
tppsfap.iiqsarGsaraGvfvvid.llirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn
|
|||||||||
| subfamily_CG42327_pd | Subfamily CG42327 | 246-318 | 1.4e-13 | 45.2 | In-house | 243-315 (319) | alignment | ||
Range on Protein: 246-318
Range on HMM: 243-315/319.0
TRPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEETDKILQKIREQRNNSIQTDQQYLFVHQVILNYC
|| |.|| ||||| |.|||| |. . . .| .. . .... .|..| ....| .|| |...|. .|.
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
|
|||||||||
| subfamily_PTPDC1_pd | Subfamily PTPDC1 | 204-314 | 1.1e-11 | 39.5 | In-house | 68-172 (182) | alignment | ||
Range on Protein: 204-314
Range on HMM: 68-172/182.0
ETVFTVEgPGGLAQKVTQYHWIDWPDRGVPTADM--AIVELLAKTrPSKGPTVVHCSAGIGRTGSVVMIEYILDQLLggqqieETDKILQKIREQRNNSI
|. |. . . |... .. . |.| ||.. . || ..| . ..| . ||| || |||| .. . . | ...| ....|..| .||
esGfsYd.lealmeqgiyvynfgwkDygvasleriLdivkvvafa.lqegkvavhChaGlGrtGvliacylvyakrl......taekaiklvrskrpksi
QTDQQYLFVHQVI
|| .| .|..
qtreqvelvkefa
|
|||||||||
| subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 44-165 | 3.2e-11 | 37.1 | In-house | 18-153 (349) | alignment | ||
Range on Protein: 44-165
Range on HMM: 18-153/349.0
VKNALEKGPAGLRAEFAamKRFNDFEKMKAfkeAQEHGKNRYKDVGCLDHNRVKLH-----------------PPWPHDYIHANFVSTP--SNPRRFICT
|.. | . | .. .|.. . . ||||||. .| ||||. ..||| ||... . | ...|.|
tkysksksmlslesddd..seiddvilseG...velfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiat
QAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKGAKKCCDYF
|||| . ||. . | ..| .. | . |.. .|| |.
qaPlPstvddfykvillngvklvlsLnddkelslekcdiyw
|
|||||||||
| subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 251-318 | 1.6e-09 | 31.9 | In-house | 263-344 (350) | alignment | ||
Range on Protein: 251-318
Range on HMM: 263-344/350.0
GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQIEE-----------TD---KILQKIREQRNNSIQTDQQYLFVHQVILNYC
| .||||||.|||| .| ....| ... ..... | |....|.|| . .|. .|..|... .|.|
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
|
|||||||||
| subfamily_Nvec-PTP-3_pd | Subfamily Nvec-PTP-3 | 119-313 | 8.6e-09 | 29.8 | In-house | 4-198 (198) | alignment | ||
Range on Protein: 119-313
Range on HMM: 4-198/198.0
RRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNiMEKgaKKCCDYFACKdkPVLefeEKGHKIIVKFESTGKMKfEKNTDAKITETVFTVEGPG-GLAQ
||.|.|| || .. |||| | . | |. . .| .| .|| |. | | . | | . | || ..| . ..
rryiatqhplretladfwqmvwetgsghivmvnd.dqk..nkeadypfyw..ptt...esgtgkygslsvttkti.ttkpdytitaliltnnttappstr
KVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK-------GPTVVHCSAGIGRTGSVVMIEYILDQL-LGGQQIEETDKILQKIREQRNNSIQTDQQYLF
....| . | .. | . . ..| || | .|||| | | || | .. . . . .. ...|. | | . |.| |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
VHQV
..||
iyqv
|
|||||||||
| subfamily_Anemone-PTP-3_pd | Subfamily Anemone-PTP-3 | 119-313 | 9.1e-09 | 29.8 | In-house | 5-199 (199) | alignment | ||
Range on Protein: 119-313
Range on HMM: 5-199/199.0
RRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNiMEKgaKKCCDYFACKdkPVLefeEKGHKIIVKFESTGKMKfEKNTDAKITETVFTVEGPG-GLAQ
||.|.|| || .. |||| | . | |. . .| .| .|| |. | | . | | . | || ..| . ..
rryiatqhplretmadfwqmvwetgsghivmvnd.dqk..nkeadypfyw..ptt...esgtgkygslsvttkti.ttkpdytitaliltnnttappstr
KVTQYHWIDWPDRGVPTADMAIVELLAKTRPSK-------GPTVVHCSAGIGRTGSVVMIEYILDQL-LGGQQIEETDKILQKIREQRNNSIQTDQQYLF
....| . | .. | . . ..| || | .|||| | | || | .. . . . .. ...|. | | . |.| |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
VHQV
..||
iyqv
|
|||||||||
| 0038934 | (Phosphotyrosine protein) phosphatases II | 218-311 | 9.4e-09 | 30.7 | In-house | 78-170 (194) | alignment | ||
Range on Protein: 218-311
Range on HMM: 78-170/194.0
KVTQYHWIDWPDRG-VPTADMAI-----VELLAkTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllGGQqieETDKILQKIREQRNNSIQTDQQYLFVH
.|. . .||.| ||. .. |. . ..| .||| ||.|||| .| | | .. .. .|| |...|.. ... ..
agieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyr...lgm...saeeAialfrekRpgaipnqdyleall
|
|||||||||
| subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 70-156 | 1.1e-08 | 29.0 | In-house | 87-174 (244) | alignment | ||
Range on Protein: 70-156
Range on HMM: 87-174/244.0
KMKAFKEAQEHGKNRYKDVGCLDHNRVKLHP-PWPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEK
|| . .. ||| .| ||| | || | || .| || || . ||| | |. .|. . .| . |.
vmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee
|
|||||||||
| PTEN_1 | 220-269 | 1.3e-08 | 29.9 | In-house | 95-149 (196) | alignment | |||
Range on Protein: 220-269
Range on HMM: 95-149/196.0
TQYHWIDWPDRGVPTADMAI--VELLAKTRP---SKGPTVVHCSAGIGRTGSVVM
.|. ....| |.|. .. . .. .. . ... .||| ||.||.| ||.
veylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
|
|||||||||
| subfamily_Sponge-PTP-4_pd | Subfamily Sponge-PTP-4 | 93-189 | 5.9e-08 | 27.1 | In-house | 7-89 (130) | alignment | ||
Range on Protein: 93-189
Range on HMM: 7-89/130.0
HNRVKlhppwPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLCNIMEKgakkcCDYFaCKDKPvLE-FEEkghKIIVKFEST
.|.. ..||.|.|| . . .. ||.|| ... ||| | |. |. . .| . |. .|. .| || .|| .|||
vsrlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deyw.pdseP.lewyee...diivtltdr
|
|||||||||
| subfamily_Cele-PTP-12_pd | Subfamily Cele-PTP-12 | 79-162 | 9.2e-08 | 25.9 | In-house | 34-119 (332) | alignment | ||
Range on Protein: 79-162
Range on HMM: 34-119/332.0
EHGKNRYKDVGCLDHNRVKLHPPWP-HDYIHANFVSTPSNPRRFICTQAPLDK-SCADFWYMCLQEKVDSIFMLCNIMEKGAKKCC
. || . |.||.||.| | |. |..| |. .| .|||.. . || | . | |... .| || .|.
nmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap
|
|||||||||
| subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 249-315 | 2.7e-07 | 24.5 | In-house | 270-335 (347) | alignment | ||
Range on Protein: 249-315
Range on HMM: 270-335/347.0
SKGPTVVHCSAGIGRTGSVVMIEYILDQLLGGQQiEETDKILQKIREQRNNSIQTDQQYLFVHQVIL
. | || | |. |. .||. |..|.| |. . |....|.|.|| . | . . |
klapvvvmcdlgldrsatvvltsiiieqvldgkt.pdcddlfkkmrdqragvftmsifytyairaal
|
|||||||||
| subfamily_DSP19_pd | Subfamily DSP19 | 225-299 | 8.7e-07 | 23.4 | In-house | 64-132 (152) | alignment | ||
Range on Protein: 225-299
Range on HMM: 64-132/152.0
IDWPDRGVPTADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVmIEYILDqllggQQIEETDKILQKIREQRNN
.| |. . . .... . ..| ..| .|||.||. |. ||| | |.. .. .. . |...||.| .
lDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv.iaylmk.....keelsleealelvrearpc
|
|||||||||
| subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 251-318 | 1.1e-06 | 22.3 | In-house | 266-344 (349) | alignment | ||
Range on Protein: 251-318
Range on HMM: 266-344/349.0
GPTVVHCSAGIGRTGSVVMIEYILDQLLGGQ----QI----EETDKI---LQKIREQRNNSIQTDQQYLFVHQVILNYC
. .|||||| |||| .| ....|. | | .| | | . ..| || . .| .|. .... .|.|.
stllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
|
|||||||||
| subfamily_CDKN3_pd | Subfamily CDKN3 | 225-312 | 1.2e-06 | 22.3 | In-house | 105-190 (202) | alignment | ||
Range on Protein: 225-312
Range on HMM: 105-190/202.0
IDWPDRGVPT--ADMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVmiEYILDQLlgGQQIEETDkILQKIREQRN-NSIQTDQQYLFVHQ
.| .|| . . |.| | . . |.||| |.||. |. .| | ..|| | ..|.|. . ..||| .|| ....
ypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslvi..aclllyl..ddtiepkd.aidklrdlkgsraiqtvkqynylse
|
|||||||||
| DSPc | Dual specificity phosphatase, catalytic domain | 239-294 | 1.4e-06 | 23.2 | Pfam-A | 62-114 (133) | alignment | ||
Range on Protein: 239-294
Range on HMM: 62-114/133.0
IVELLAKTRPSKGPTVVHCSAGIGRTGSVVmIEYILDQLlgGQQIEETDKILQKIR
.|| ..| . ... .||| ||| |..... | |.... . ...| ..... |
avefiekaeqkgkkvlVHCqaGisRSatli.iaYlmktk..nlslneAyefvkerr
|
|||||||||
| DSPc | Dual specificity phosphatase, catalytic domain | 239-294 | 1.4e-06 | 23.2 | In-house | 62-114 (133) | alignment | ||
Range on Protein: 239-294
Range on HMM: 62-114/133.0
IVELLAKTRPSKGPTVVHCSAGIGRTGSVVmIEYILDQLlgGQQIEETDKILQKIR
.|| ..| . ... .||| ||| |..... | |.... . ...| ..... |
avefiekaeqkgkkvlVHCqaGisRSatli.iaYlmktk..nlslneAyefvkerr
|
|||||||||
| subfamily_Cele-PTP-5_pd | Subfamily Cele-PTP-5 | 132-321 | 1.7e-06 | 20.9 | In-house | 131-312 (346) | alignment | ||
Range on Protein: 132-321
Range on HMM: 131-312/346.0
CADFWYMCLQEKVDSIFMLCNiMEKGAKKCCDyfackdkpVLEFEEKGhkiivkFESTGKMKFE-KNTDAKITETVFTVEG-PGGLAQKV-TQ-YHWIDW
||||| ||... .... .| . ... |. | .. |||| . . .| .|.| | | .. | | .| |
vedfwymiyqeqihlvylmvp.ddklknttts........lfndengg......yqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapw
PDRGVPTADMAIVELLAKT-----RPSKGPTVVhCSAGIGRTGSVVMIEYILDQLLGGQQIEeTDKILQKIREQRNNSIQTDQQYLFVHQVILNYCLDK
| . |. .. . . | || | ||. | . | ..|| | . . .|...|..|| .... || .. ....| |
khlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepn.iceimknikqqrpggvesfaqyasiyaivfdyiark
|
|||||||||
| subfamily_CDC14_pd | Subfamily CDC14 | 231-312 | 2e-06 | 21.9 | In-house | 245-320 (328) | alignment | ||
Range on Protein: 231-312
Range on HMM: 245-320/328.0
GVPTaDMAIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIeYILDQLlggqQIEETDkILQKIREQRNNSIQTD-QQYLFVHQ
..|. |. . ..|. . ..| .||| ||.||||... |.. . .. .. .. .| | |. . |..| .|
stPs.daivkkfleiaekaeGaiavhCkaGLGrtGtLiac.ylmkhy....rftaae.aiawlricrPGsvigpqqkfleekq
|
|||||||||
| PTPc_motif_SM00404 | 239-276 | 2.8e-06 | 22.3 | In-house | 69-106 (140) | alignment | |||
Range on Protein: 239-276
Range on HMM: 69-106/140.0
IVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDQ
... . . . ..| .||| ||. |...... ... .
vldfienaekkggkvlVHCqaGvSRSatliiaYlmryr
|
|||||||||
| subfamily_PTEN_pd | Subfamily PTEN | 253-311 | 3.6e-06 | 22.1 | In-house | 117-173 (184) | alignment | ||
Range on Protein: 253-311
Range on HMM: 117-173/184.0
TVVHCSAGIGRTGSVVmIEYILDQLLGgQQIEETDKILQKIREQRNNSIQTDQQYLFVH
|||| || |||| .. . |.| .|| .. ||. .. ...| . ..... | .|.
vvvHCkaGkGRtGvli.vayllkslll.ekaeealelfaeaRtknkkgvtiPsqrRYve
|
|||||||||
| subfamily_DSP23_pd | Subfamily DSP23 | 225-312 | 6.8e-06 | 20.8 | In-house | 57-140 (148) | alignment | ||
Range on Protein: 225-312
Range on HMM: 57-140/148.0
IDWPDRGVPTADM--AIVELLAKTRPSKGPTVVHCSAGIGRTGSVVMIEYILDqllggQQIEETDKIlQKIREQRNNSIQTDQQYLFVHQ
. .| |. . .|... .. . ||| | ||||... .. ... .. | ..|..| |..| .| |..
lriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvke.....rklaaaeai.aevrrlrpgsvetveqeklvrd
|
|||||||||
| subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 78-151 | 8.2e-06 | 19.6 | In-house | 36-117 (347) | alignment | ||
Range on Protein: 78-151
Range on HMM: 36-117/347.0
QEHGKNRYKDVGCLDHNRVKLHPP--------WPHDYIHANFVSTPSNPRRFICTQAPLDKSCADFWYMCLQEKVDSIFMLC
.. ||| ||| | || | | .. || | . . .| || || .. ||| | || . .
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
|
|||||||||