Gene ZK616.65 in Caenorhabditis elegans

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf13
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP238_AA protein Get Run
CeleP238_AA_246-521 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 248-527 5.4e-205 673.1 In-house 1-281 (281) alignment 
Range on Protein: 248-527
Range on HMM: 1-281/281.0
FAMSSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKV-MPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRM
||||||||||||||||||||||||||||||.||||||||||||||||||||||||||| |||||||||||||||||||||||||||||||||||||||||
famssqkmtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrm

IWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS
|||||||||||||||.|||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
iwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars

TPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRVTGRAASVQTLQQYMLIWKVLLDFGVAYKQITEELAE
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
tppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqiteelae
0050432 (Phosphotyrosine protein) phosphatases II 251-518 1.9e-81 269.1 In-house 35-302 (308) alignment 
Range on Protein: 251-518
Range on HMM: 35-302/308.0
SSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLkvmpnKNSTDYIHANYIRSP--FLKRGYILTQGPKKETRADFWRMIW
  ... |  ...||  |.  .|.  ......| | .|||| .|...| ||| |     ....|||.|.|.. .   |.| .|.||||...| .|||||.|
lekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

QENTTAIVMLCQFTETNREKCAEYFPRNAH-CCLQFDKMSVSYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR
..|.. ||||....| .|||||.|.| . .  .|...|..| . . .|... ... | |..  .||.| .||. .. ||| .|| | | .|..|...| .
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

--STPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAY
  . | |.||||||||.||. |....|. .. .   .|. ..| .||   |. .|||..||... ..||..   .
lpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReq.Rpgmvqtpeqylflyralleylklk
0051299 (Phosphotyrosine protein) phosphatases II 254-514 3.7e-79 261.5 In-house 19-285 (288) alignment 
Range on Protein: 254-514
Range on HMM: 19-285/288.0
KMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTT
.  |  ...||  |.   |.  ..|.. | | .|||| .|...| |||.|.|... ...|||.|.||. . ||| .|.||||...| .|||||.|..|..
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

AIVMLCQFTETNREKCAEYFPRnaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS------YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR--
 ||||....| .||||| |.|   . .|......| . . .|... ... | ..      ..||.| .||. .. ||| .|| | | .|..||..|    
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

--STPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
  . | |.||||||||.||. |....|. .. .   .|. ..| .|| . |  .|||..||... ..||..
sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlr.eqRpgmvqtpeqyrfvyealley
0040438 (Phosphotyrosine protein) phosphatases II 247-516 5e-79 261.1 In-house 7-277 (317) alignment 
Range on Protein: 247-516
Range on HMM: 7-277/317.0
DFAMSSQKMTLDDFKQEFSNLPGDPPSdLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRM
.. .   |.    ...|| .|.  ...  .. .. |.| .|||| .|...| |||.|..... ...|||.|.|.  | ||| .|.||||...| .|||||
lalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrm

IWQENTTAIVMLCQFTETNREKCAEYFPRnaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA
.|....| ||||....| .|||||.|.|      |......| . . ..... . ..| ..  ...|.| .||. .. |||  || | . .|..|...|.
vweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

R----STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFtLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGV
     ..| ..||||||||.||. |....|. .. .   .|....| .||   |. .|||..||. . ..||..  
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelre.qRpgavqtpeqyrflydalleylk
0036941 (Phosphotyrosine protein) phosphatases II 253-520 9.4e-79 260.1 In-house 8-282 (297) alignment 
Range on Protein: 253-520
Range on HMM: 8-282/297.0
QKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLkvmpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENT
... |  ...||. |.   ..  ..... | | .|||| .|...| .||.|    .....|||.|.|.  . ||| .|.||||...| .|||||.|..|.
kllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

TAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTV--NKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA----
| ||||....| .|||||.|.| .    |......| . . .|  ... ... | ...  .||.| .||. .. |||  || | . .|......|     
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--RSTPPVIHCSAGVGRSGTLMAVEIALQSIHS--HFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAYKQ
  ...| ..|||||||||||. |....|| ...  .   .||...| .||   |. .||||.||. .  .||..   ...
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReq.Rpgavqtleqyrflyeallellkkklt
0046845 (Phosphotyrosine protein) phosphatases II 260-518 3.7e-77 254.8 In-house 2-277 (284) alignment 
Range on Protein: 260-518
Range on HMM: 2-277/284.0
FKQEFSNLPGDPPSD--LCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNK-NSTDYIHANYIRSP-----FLKRGYILTQGPKKETRADFWRMIWQEN
...||  |.   ..    ..... | | .|||| .|...| ||| ||..... ...|||.|.|.. .       |. .|.||||...| .|||||.|..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TTAIVMLCQFTETNREKCAEYFPRNaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR---
.. ||||....| .||||| |.| . . .|......| . . .|... ....| |..   .||.| .||. ...||| .|| |.| .|..||..|     
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

---STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFT--LPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAY
   . | |.||||||||.||. |....|. .. . .   .|. ..|..||   |  .||||.||... ..||..   .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlre.qRpgmvqtleqyrfvyealleylklk
0047943 (Phosphotyrosine protein) phosphatases II 253-513 2.9e-76 251.9 In-house 7-270 (273) alignment 
Range on Protein: 253-513
Range on HMM: 7-270/273.0
QKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLkvmpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENT
..  |. ...||  |.  .|.  ..... | | .|||| .|...| ||| |    . ...|||.|.|.. . ||| .|.||||...| .|||||.|..|.
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

TAIVMLCQFTETNREKCAEYFPRNAHC-CLQFDKMSVSYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA-----
. ||||....| .||||| |.| .     |...|..| . . ..... ... | |..   ||.| .||.....||| .|| | | .|......|      
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
 ...| |.||||||||.||. |....|. .. .   .|....| .||   |  .|||..||... ..||.
psngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsq.Rpgmvqtpeqyrflyealle
DSPc_SM00195 260-514 3.9e-76 251.2 In-house 2-261 (263) alignment 
Range on Protein: 260-514
Range on HMM: 2-261/263.0
FKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLC
.|.||..|    ... .|  ... |..|||| ||.. | .||.||  ..|...|||.||||. .  |. ||.||||...| .|||||.|.|... ||||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNK-SLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR----STPPVIH
.. | ..|||..|.|....   .|.|.||   . .  | ..... |.|..||  ||| .|.. .|.||| .|| | . .|..||... .    |.| |.|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTLMAVEIALQSIHSHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
|||||||.||.....|.|........ .||..||..|| . |. .||||.||. | ...|..
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelR.kqRpgmvqtleqYlfiyeailey
PTPc_SM00194 260-514 3.9e-76 251.2 In-house 2-261 (263) alignment 
Range on Protein: 260-514
Range on HMM: 2-261/263.0
FKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLC
.|.||..|    ... .|  ... |..|||| ||.. | .||.||  ..|...|||.||||. .  |. ||.||||...| .|||||.|.|... ||||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

QFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNK-SLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR----STPPVIH
.. | ..|||..|.|....   .|.|.||   . .  | ..... |.|..||  ||| .|.. .|.||| .|| | . .|..||... .    |.| |.|
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGVGRSGTLMAVEIALQSIHSHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
|||||||.||.....|.|........ .||..||..|| . |. .||||.||. | ...|..
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelR.kqRpgmvqtleqYlfiyeailey
0043336 (Phosphotyrosine protein) phosphatases II 255-513 9.7e-76 250.2 In-house 17-275 (278) alignment 
Range on Protein: 255-513
Range on HMM: 17-275/278.0
MTLDDFKQEFSNLPGDPPsDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTA
     ...|| .|.  .. | .. .. | | .|||| .|...| |||.|..... ...|||.|.|.  .  .|..|.|||| .|| .|||||.|....| 
nlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

IVMLCQFTETNREKCAEYFPrnaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA----RSTP
||||....| .|.|||.|.|      |......| . . ....  ... |...  ..||.| .||. .. ||| .|| | . .|..|...|     ...|
ivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngp

PVIHCSAGVGRSGTLMAVEIALQSIHSHFtLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
 ..||||||||.||..|....|. ....   .|. ..|..||   |. .|||..||. . ..||.
vlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreq.Rpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 259-514 5.1e-75 248.0 In-house 33-288 (297) alignment 
Range on Protein: 259-514
Range on HMM: 33-288/297.0
DFKQEFSNLPGDPPSdlCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNK-NSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTTAIV
 ...|| .|.  .|.  .. .. |.| .|||| .|...| |||.||....  ...|||.|.|.  . | .| .|.|||| .|| .|||||.|....|.||
llllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtviv

MLCQFTETNReKCAEYFPRNAHcclQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA------RSTPPV
||....| .| |||.|.| .     ......| . . ....  ... |.....||.| .||...  ||| .|| |.|..|..|...|       ...| .
mLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvl

IHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
.||||||||.||. |  ..|. ....   .|....|..||   |  .|||..||. . ..||..
VHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelr.eqRpgavqtpsqyrflydallel
0045450 (Phosphotyrosine protein) phosphatases II 260-514 2.3e-73 243.0 In-house 29-303 (307) alignment 
Range on Protein: 260-514
Range on HMM: 29-303/307.0
FKQEFSNLPGDPP--SDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNK-NSTDYIHANYI--------RSPFLKRGYILTQGPKKETRADFWRMIW
...||  |.   .  .. ..... |.| .|||| .|...| .||.|...... ...|||.|.|.         .. ||| .|.||||..|| .|||||.|
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlw

QENTTAIVMLCQFTETNREKCAEYFPRNaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA-
....|.||||....| .|||||.|.| .    |..... | . . .. .... ..|...   ..||.| .||. ...||| .|| | | .|......|. 
eqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrka

-----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTL--PDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
     ...| ..||||||||.||..|  ..|. .... ||  .|. ..|..||   |  .||...||. . ..||..
leelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllr.eqRpgavqnpeqyrflyeallel
Y_phosphatase Protein-tyrosine phosphatase 284-512 3.6e-72 237.9 Pfam-A 1-234 (235) alignment 
Range on Protein: 284-512
Range on HMM: 1-234/235.0
NNKKNRYLNIPCLDISRVQLkvMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQF
| ||||| .|.. | .||.|    .....|||.|||...   |. .|.|||| |.| .|||||.|||....||||.. .| .|||||.|.|.. .  |..
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DKMSVSYE-DST-VNKSLVTTRLNLSYEGET---RLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----TPPVIHCSAGVGRSGTLMAVEIALQSIH
....| .. ...  .|. ... |.|. ..|    | .... ...|||..|| |.. .|...||.. ..    .| |.||||||||.||..|..|.|....
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

SHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
.. . .|..|||..|| . |. .||.|.||. . |..|
aeee.vdvlqivkelR.kqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 284-512 3.6e-72 237.9 In-house 1-234 (235) alignment 
Range on Protein: 284-512
Range on HMM: 1-234/235.0
NNKKNRYLNIPCLDISRVQLkvMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQF
| ||||| .|.. | .||.|    .....|||.|||...   |. .|.|||| |.| .|||||.|||....||||.. .| .|||||.|.|.. .  |..
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

DKMSVSYE-DST-VNKSLVTTRLNLSYEGET---RLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----TPPVIHCSAGVGRSGTLMAVEIALQSIH
....| .. ...  .|. ... |.|. ..|    | .... ...|||..|| |.. .|...||.. ..    .| |.||||||||.||..|..|.|....
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

SHFTlPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
.. . .|..|||..|| . |. .||.|.||. . |..|
aeee.vdvlqivkelR.kqRpgmvqsleqYiflykail
subfamily_PTPRD_pd Subfamily PTPRD 246-514 7.4e-71 234.5 In-house 11-280 (564) alignment 
Range on Protein: 246-514
Range on HMM: 11-280/564.0
KDFAMSSQKMTLDDFKQEFSNLPGDpPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWR
|..  . ..    .|..|. ..    ..  ..| |.|.| .|||| ||   | ||| |. .......||| |..| .   .. || ||||..|| .||||
kehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWR

MIWQENTTAIVMLCQFTETNREKCAEYFPRNaHcCLQFDKMSVSYEDSTVNKSLVTTRLNL--SYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIR
|.|..|.. |||| .  | ...||..|.| . .   ..... |. |...  .  . . ..|  . . |.| .... . .|||  || | . .|...||.|
mvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvr

AR----STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
|     . | |.||||||||.|| ..... |. |..  |. || |.|..|| . | | ||| .||. |....|..
alnepdagPivVhCSaGVGRTGtfividamlerikeektv.Diyqyvkalr.kqRnamVqteeQYiFiheailea
subfamily_PTPRB_pd Subfamily PTPRB 240-514 8.8e-69 226.7 In-house 7-284 (293) alignment 
Range on Protein: 240-514
Range on HMM: 7-284/293.0
AYRKLFKDFAMSSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKET
   . |... .. .. .   |..|...|     .  ..| ...||..|||| ||   | |||.|. . .....||| ||||.    .| .| ||||  ||
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet

RADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCClQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKIL
. |||||.|......|||| |  |  ..|| ||.|.. . . .. ...|.   ... .  |.  |... | |.| .... .. |||. || ... .|...
vddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfv

RKIRARS------TPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
|..| .       .| |.||||||||.||..|..  ||.|... .. ||  ||..|| . |.  ||| .||. | ...||.
rtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyv.difgivaelRee.RnllvqtekqYifihqcvldl
0040439 (Phosphotyrosine protein) phosphatases II 276-514 2.1e-68 225.9 In-house 3-245 (249) alignment 
Range on Protein: 276-514
Range on HMM: 3-245/249.0
CTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPR
.. .. |.| .|||| .|...| |||.|...|. . .|||.|.||  .  || .|.|||| .|| .|||||.|... |.||||....| .|||||.|.| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

naHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA------RSTPPVIHCSAGVGRSGTLMAVE
     |......| . . .|....... | |.  |.||.| ..|. .  ||| .|| | | .|......|       ...| ..||||||||.||. |  
..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

IALQSIHSHFTlPDIKQIVSHLRVTGrAASVQTLQQYMLIWKVLLDF
..|. .. . .  |....|..||      .||...||. . ..||..
lmleqlekelg.vdleeavkllrsqR.pgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 276-513 5.9e-68 224.2 In-house 1-241 (245) alignment 
Range on Protein: 276-513
Range on HMM: 1-241/245.0
CTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPR
.. .. |.| .|||| .|...| .||.|..... . .|||.|.|.  .  ....|.|||| .|| .|||||.|... |.||||....| .|.|||.|.| 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

naHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA-----RSTPPVIHCSAGVGRSGTLMAVEI
  .. |......| . . ......... |...  ...|.| ..|...  ||| .|| ..| .|..|. .|      ...| ..||||||||.||..|. .
..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaayl

ALQSIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
.|. ....    .. ..| .||   |  .|||..||. . ..||.
mleqleke.lgvsleeavkelrsq.Rpgavqtpsqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 258-515 2e-66 219.6 In-house 7-272 (278) alignment 
Range on Protein: 258-515
Range on HMM: 7-272/278.0
DDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQlkvmpnknstDYIHANYIRSPflKRGYILTQGPKKETRADFWRMIWQENTTAIVM
 |...|| .|.  .. . .| .. . | .|||| .|...| |||           |||.|.||...  .. .|.||||...| ||||||.|....|.|||
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivm

LCQFTETNREKCAEYFPRnaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS------YEGETRLITHWLWKEWPDWQVPGSS--EVMLKILRKIRA-----
|....| .|||||.|.|   . .|......| ... .|..  ....|..       ...|.| .||. .. |||  || ..    .|..|. ||.     
ltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

------------RSTPPVIHCSAGVGRSGTLMAVEIALQSIhsHfTLPDIKQIVSHLRVTGRAASVQTLQQYMLIWKVLLDFG
            ...| ..||||||||.||| |. . |. .  .    |. ..|..||   .  .||.|.||. . ..||.. 
aslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN9_pd Subfamily PTPN9 257-520 6.8e-62 204.2 In-house 15-295 (297) alignment 
Range on Protein: 257-520
Range on HMM: 15-295/297.0
LDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIV
    ..|. ..   |..   .|.....| .|||| .. |.| .||.|. ..... .|||.||..     |...| |||| |.|  |||||.|....  ||
krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

MLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR---------
|  .. |. | ||..|.| . . . .| ..|||  .  ...  ... |...   ..|.| .||.    |||. || |.. .|..|.|.| .         
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelg

-------STPP-VIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGVAYKQ
       | || |.|||||.||.||.....|.|. ...  |. |. . |..|| | || |.|| .||.. .. .|.. .  |.
dewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtv.dvvetvkllr.tqrafsiqtpeqyefcylavleyalelka
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 259-526 6.5e-61 201.1 In-house 21-293 (318) alignment 
Range on Protein: 259-526
Range on HMM: 21-293/318.0
DFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
 ...|. .|  .. .   .  ..|||..|||| ||   | .||.|. . .....||| ||||     |. || .|.|  ||  |||||.|. |.. ||||
llseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml

CQFTETNREKCAEYFPRNAhcCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS-----TPPVI
 | .|  ..|.. |.| .     ...|. |  ....  ...|  ..... ..  |.| .  . . .|||  || |.  .|...|....       .| |.
tqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivv

HCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAYKQITE--ELA
|||||||| |. .||.| |. |.   .. |. |.|..||   | . ||| .|| .|..|||..  .... ..  .|.
hCsaGvGrtGvfiavdillerikaealv.Dvfqtvkqlreq.rnlmvqtedqyefiydvllealasgdtevdasdlr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 249-517 1.1e-60 200.3 In-house 14-285 (319) alignment 
Range on Protein: 249-517
Range on HMM: 14-285/319.0
AMSSQKMTLDDFKQEFSNLPGDPPSDLCTAfNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIW
 .  .. .   ...|| .| .  . .. .| ... |.||||| ||   | .||.|. .......||| |..| .   .. .| ||.|...|  |||||.|
lkalastgetllekefkllkeavndtfdsa.skeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvW

QENTTAIVMLCQFTETNREKCAEYFPRNahCCLQFDKMSVSYEDSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA-
.|..  .|||.. .|  . |. .|.|..  .  .. .. |  |.    . ..  .|.|     | ||| ..|. ..|||| .|| ..  .|..|..||  
eeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirks

----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGVA
     | | |.|||||||| || ......|. ..   .| |. ..||.|| | |   ||. .|| .|...||..  |
rektqsgPivvhCsaGvGRtGtfivldamlervkeegvl.DvfstvsrlR.tqRnimvqrpeqYkfiyealleavea
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 251-514 1.5e-60 199.7 In-house 14-278 (288) alignment 
Range on Protein: 251-514
Range on HMM: 14-278/288.0
SSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQE
  .... ..|..|. .|.    ..  || ...||.||||| ||  .|  ||.|| .......||| |.|| .   |. || ||||  .|  |||......
kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

NTTAIVMLCQFTETNREKCAEYFPRNAHcCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----
.|. |||| .. | ...|| ||.| . .   .. .. |   .|   .. |. .| |  ... . ||.. .. ||| .|| |.. .|..||..   .    
ktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadt

TPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
 | ..||||||||.|| .|.. ... .... .. |.  .|..||   ||  ||||.||. |..|||. 
gpiivhCsaGvGrtgtFialdalidaveeedyi.DvagtvaklRkq.RallvqtlkqYefiyevllsl
0037934 (Phosphotyrosine protein) phosphatases II 276-512 1.5e-60 200.1 In-house 2-239 (243) alignment 
Range on Protein: 276-512
Range on HMM: 2-239/243.0
CTAFNQPVNNKKNRYLNIPCLDISRVQLkvmpnkNSTDYIHANYIRSPflkRGYILTQGPKKETRAD----FWRMIWQENTTAIVMLCQFTETNREKCAE
.. .. |.| .|||| .|...| ||| |      ...|||.||.|. .   ...|.|||| .|| .|    ||||.|....|.||||....| .|||||.
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YFPrNAHcclQFDKMSVSYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIR------------ARSTPPVIHCSAG
|.| . .   ......| . .... .. . . | |..   ...|||..|...  ||| .|| | | .|..|...|             .. | ..|||||
ywp.gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

VGRSGTLMAVEIALQSIhsHftlPDIKQIVSHLRVTGRAASVQTLQQYMLIWKVLL
|||.||| |  . |. .  .    |. ..| .||      .|||..||. . ..||
vgRtGtliaaylmllll..g...vdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPRA_pd Subfamily PTPRA 258-515 3.6e-60 198.6 In-house 32-295 (330) alignment 
Range on Protein: 258-515
Range on HMM: 32-295/330.0
DDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVM
  |..|| .||  |    . . ..  |..|||..||   | ||| | |.  ....||| | .|     |  .| .||||.||  |||||||. ....|||
klfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativm

LCQFTETNREKCAEYFPRNAhcCLQFDKMSVSYEDS------TVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR----ST
| .. | ..|||| |.| .   .. . .. |. ||.      || | ||.   . . | ..||.. . .. |||  ||  .  |||.|.|...     . 
ltelkerkeekcaqywPdeG..lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag

PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFG
| |.||||||||.||.....  |. ...   . |. ..|..||   |.  |||..|| .|.||||.. 
pivvhcsaGvGrtGtfivldavlervkaerkv.dvfefvkrlrlq.rpqmvqtdeqyefiykvlleyy
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 254-513 4.8e-60 198.0 In-house 11-274 (281) alignment 
Range on Protein: 254-513
Range on HMM: 11-274/281.0
KMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTT
.     |..|...|     ..  || ... | .|||| ||   | .||...   ....|||| ||.. .   ...|| ||||  .. ..||.|.|... .
qndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

AIVMLCQFTETNREKCAEYFPRNAHcCLQFDKMSVSYEDSTVNKSLVTTRLNL-SYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKI---RAR--ST
||||. .  |... ||  |.| ...  |.. .. |. . .. ... .. ...|   .|||| ...  .. |||  || ... .|.  ...   . .   .
aivmvtreieagklkChrYWPddns.elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktka

PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
| ||||||||||.|| .|.. ........ .  |.|..| .|| . |   |||. ||  ..|..||
plvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrke.rnlmvqtvvqyefvykavld
subfamily_PTPN12_pd Subfamily PTPN12 279-516 8.8e-60 197.0 In-house 35-278 (290) alignment 
Range on Protein: 279-516
Range on HMM: 35-278/290.0
FNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAH
 ....| ||||| .|   | |||.|. . ...  ||| ||.|. .  |  || .|||  .|  |||||||. |.. .||.|.  | .. ||. |.| . .
gekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

CCLQFDKMSVSYED-STVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA----RSTPPVIHCSAGVGRSGTLMAVEIALQSI
  |.|....|. |.  .|.. ..   |..  ..|.| .. . ...||| .|| | . .|......|      ..| |.|||||||| ||..|.... . .
eelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrell

HSHFT--LPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
... .    |. ..| .|| . ||| ||| .|| |..| ....  
kaekipeeldvfdlvlelr.kqraalvqtkeqyelvykavaelvq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 243-521 1.8e-58 192.5 In-house 12-289 (290) alignment 
Range on Protein: 243-521
Range on HMM: 12-289/290.0
KLFKDFAMSSQKMTLDDFKQEFSN--LPGDPPSDL-CTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpNKNSTDYIHANYIRSpfLKRGYILTQGPKKET
. |. || .  |.. |.. .|. .   |  |   |    |..  . ||||| ...| |..|| ||   .    ||.||||..   ||  .|||||. |.|
eafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkG..lkamfiltqGalkdt

RADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTR-L--NLSYEGETRLITHWLWKEWPDWQVPGSSEVML
  |.|||. ||...||||||.  |  . ||..|.| ..   | | ...|    .. . . .  . |      .|    . |.  | |||  |. |.  .|
vidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlall

KILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAYKQI
..|| .|  | | |.|||||.||.||..|.|..|| .     | |. ..|  ||   |..|||   ||... ..|||.|...| |
rtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkel.dlldlvralrn.srlnsvqvdiqylalveilldlGkdfkyi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 259-514 3.2e-56 185.4 In-house 6-267 (274) alignment 
Range on Protein: 259-514
Range on HMM: 6-267/274.0
DFKQEFSNLPGDPPSDlctAFNQPVNNKKNRYLNIPCLDISRVQLKV-MPNKNSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTTAIV
|...|| .|| . . .     . . ...|||| .|   . ||| |.   .... ..|| ||||. .   .. |. ||||  .| |||||||.||... ||
dlekeflelPlnfdqe...eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MLCQFTETNREKCAEYFPRNAHC--CLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA-------RST
|| ...|.|..|||.||| . ..    .......  |. . ..    ..| |.|  ..| ..|... .||| ..| . . .|.......        . .
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenakla

PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
| |.|||||.|| |  .|..||.. .. . .. |. .||..||.  |   ||| .|| ||...|  .
pvvvhCsaGiGrtGcfiaisiavrqlreeivv.dvlkivcnlrld.rGGmvqtseqyelihralcly
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 238-514 4.8e-56 185.2 In-house 7-289 (298) alignment 
Range on Protein: 238-514
Range on HMM: 7-289/298.0
REAYRKLFKDFAMSSQKMTLDDFKQEFSNLPGDPP---SDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQG
 | ...... .|  ..|..|  ...|| .|        ..  .. ..| |.||||| .|  || ||| |. . ... .||| | .. .   .  .|.||.
aedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqa

PKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHccLQFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSS
| .|| .|||||...|. ..|||| . .|... |. .|.| . .   ......||   . .   |....|..| .   ..| . .  . .||| .||  .
PltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk..etygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpena

EVMLKILRKIRARS-----TPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
. .|..|||.||       .| ...|||||||||| .|..  |. ..   .. |. |.|  ||.. |...||| .||. |... |..
tsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv.DvfqvvkvlRkk.rpgavqteeqYvfiyeavlea
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 284-514 9.5e-55 180.5 In-house 20-263 (270) alignment 
Range on Protein: 284-514
Range on HMM: 20-263/270.0
NNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIR-SPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCC--
..| ||| .|     .||.|. . ... | || |||.|     |. || ..||.. |  .||||||.|..|||||. ...| .|.||. |.| ...    
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

LQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSE------VMLKILRKIR------ARSTPPVIHCSAGVGRSGTLMAVEI
|.. |..|  . .. ..  ..|||.| ..||.| ..|. ...|||  || ...       .||.||..|      ....| ..||||||||.|||.|..|
ledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDi

ALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
|.. ....  . |. .|...||   | | ||. .|| ...|... .
avrlLeetkkv.dvlaiieelR.kdRmalvqhpeqyeflykavvey
subfamily_Ptp69D_pd Subfamily Ptp69D 251-517 1.2e-54 180.5 In-house 15-288 (307) alignment 
Range on Protein: 251-517
Range on HMM: 15-288/307.0
SSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQE
|... |   ...|. .|.    .  ... ..  |. |||| .|   |  ||.||... |...||| |..|..   |. .|  |.|  .|  ||||||.. 
srkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeq

NTTAIVMLCQFTETNREKCAEYFPRNahCCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEG-------ETRLITHWLWKEWPDWQVPGSSEVMLKILRKI-
. | |||| . ||.||.||| |.| .     |.... | . ..   .  .   |..|  .       ..| .. . ...|.| .|| ... .||..... 
evtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvr

---RARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVA
   .   .| |.||||||||||...|... || ..   .. || ..| .||   |   || |.||. ... |||.   
elyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkv.difetvkdLrsq.RnllvqsleqYvflyralldyssy
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 251-536 2.1e-52 173.1 In-house 9-301 (307) alignment 
Range on Protein: 251-536
Range on HMM: 9-301/307.0
SSQKMTLDDFKQEFSNLPGDPPSDLCT-AFNqpVNNKKNRYLNIPCLDISRVQLKVmpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQ
 . .. .. ...||..|    |  . . ||.   |..|||| ...| | .|. .|.  .  ..|||||||.      . .| .|||...|. .|| |. |
rtldkgvqalvdefrvlakktpegvtveafs..antdknryqdvkcqdkgrivvkf..dglasdyihanylgiaikpkkficaqgplentqysfwamaiq

ENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKM--SVSYEDSTV------NKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRK
|.  ...|||.  |. . || .|.| .    | | .   ..| ..  .      .. .  | |.. . ...| |.|. |..|||  ||      . .|  
ekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea

IRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV-AYKQITEEL--AEKFNATYRRS
.|    | |.|||||||||||..|. .  . . .     |.|..|  ||   |  ..||  ||. . .|||.. .  ||.  |||  .....  | . 
vrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsq.rhyaiqteaqylylhrvlleyflelyketyeellltknyeekyakw
subfamily_PTPN6_pd Subfamily PTPN6 251-516 2.6e-52 172.7 In-house 19-298 (306) alignment 
Range on Protein: 251-516
Range on HMM: 19-298/306.0
SSQKMTLDDFKQEFSNLPGDPPSDLCT--AFNQPVNNKKNRYLNIPCLDISRVQLKvMPNKNSTDYIHANYIR--SPFLKRGYILTQGPKKETRADFWRM
......  .|..|| .|  .  ..| .    ..| |..|||| ||   | .|| ||  |.   .||| ||||.  ..  .. || |||  ..| .|||||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

IWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLqFDKMSVSYEDSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIR
.||||.. |||. . .| ..|||| |.| . .    . |.||.  ... ... .  .|..|    ..|.| . .. .|.|||  || . ...|. |....
vwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

ARS--------TPPVIHCSAGVGRSGTLMAVEIALQSIHSHF--TLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
...         | |.|||||.|| ||.. ..| |. |...   .  ||...|  .| . |   ||| ||| ...|..  .  
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvr.eqrsglvqteqqykfvykaikkyie
subfamily_PTPRK_pd Subfamily PTPRK 259-536 2.6e-52 172.6 In-house 23-296 (314) alignment 
Range on Protein: 259-536
Range on HMM: 23-296/314.0
DFKQEFSNLPGDppsdlCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
 ||.|. .|.         | ..  |..|||. .|   | |||.|... . .|.||| |..| |    . .| ||||..|| .||||....||...||||
gfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivml

CQFTETNREKCAEYFPRNAHC--CLQFDKMSVSYEDSTVNKSLVTTRLNLSYEgETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARST----PPVIH
 ...|. | || .|.| ...    ..   .... .   |.. .  ..|. ..| |.|.. .. .  |||..|| | . .||..|.. . .     . |.|
telvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqe.eirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvh

CSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGVAYKqiTEELAEKFNATYRRS
|||| ||.|| .|..| |. |. . .. |. ..|  || . .   |.| .||..|. |.|.  .. .  |   . .|.|.|  |
CsaGaGrtGtfiaidivldmieregvv.dvfnavktlrsr.kvnmveteeqykfiydvileaclcge..taipvsefkalyles
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 251-514 3.7e-52 172.4 In-house 15-282 (305) alignment 
Range on Protein: 251-514
Range on HMM: 15-282/305.0
SSQKMTLDDFKQEFSNLPGDppSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQE
...... ....... .|. .  .. .   .. .|..|||. .|  || .|..|.  .... .||| |.|. .   |  ||..||| |.| |||||.|..|
earvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrlivee

NTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARST
 .. ||||..  | ...||  |.| .     .|...||  ....  . ... .|..|    . |.| ....   .|||  || ..  .|....... .  
kvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqk

-----PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
     | ..||||||||.|. .||.|||. ..   .. |. ... .|| . |   ||||.||. .. .| . 
kdkgvpllVhCsagvgRtGvfiavdialerlkkEevv.dvfevlkqlRsk.rmkmvqtldqYvflhdaldel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 258-513 3.4e-51 169.0 In-house 19-275 (315) alignment 
Range on Protein: 258-513
Range on HMM: 19-275/315.0
DDFKQEFSNLPGDPPSDlCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVM
  | .|| .||. ...   ..  ...| ||||| ||  || .||.|.|. ..   ||| | ||.|    . || .|||.| .  |||||..||..|.|||
alfseefhdlpdPdiyr.qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivm

LCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----TPPVIHC
. .  | .. ||. |.| .     .| ...|.  .   .   |. .| .    |.| .| . ..||||  |.  .  .||......|       . ..||
vtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhc

SAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD
||||||.| .....  .. |.      |. ..|  ||   |   ||| ..| .|. ..|.
saGvGrtGvvisidevvaqikrt.rsvdvfnfvknlra.krpylvqteeeyafiydavle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 259-529 3.7e-51 168.7 In-house 23-301 (305) alignment 
Range on Protein: 259-529
Range on HMM: 23-301/305.0
DFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
 ...||...      .   || .  ...|||| .. |||  ||.|.   .    .||||||. .|   . .| || | ..| |||| | .|..  || ||
glraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkle...gpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifml

CQFTETNREKCAEYFPRNAHCCLQFD----KMSVSYEDSTVNKS-------LVTTRLNLSYEG-ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS
|.. |   .||.|||. . .  |.|.    |.|| .| |.  |        .  | | .   | ..| .||. | .|||  || .   .|..| | |.  
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk

TPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAYKQITEELAEKF
 | |.|||||.||.|... .|  |. . .   . | ..|. ..|   |  |.|| .||... .|.|..    | . ||  | .
gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkire.qrnnsiqtdaqylfvhqvilnyfrkkklldeevkeay
subfamily_PTPRG_pd Subfamily PTPRG 260-514 6e-51 168.3 In-house 21-286 (563) alignment 
Range on Protein: 260-514
Range on HMM: 21-286/563.0
FKQEFSNLPGDPPSD--LCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNST-DYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIV
|..|| .|     |.   ... ..| | .|||||||   | |||.|. .|.|... ||| ||||     .. .| |||| |.|  |||||||..|.. ||
fseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv

MLCQFTETNREKCAEYFPRnaHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSY-----E---GETRLITHWLWKEWPDWQVPGSSEVMLKILRKI-RARST
|. ...| .|.||  |.|.     .......|  ... |  .  . .| .       .    . .|.... . .||| .|| .|   |.  .|  .|. .
mitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

---PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
   | |.||||||||.||.....  |. |... .  .. ... |.|   |   |||  ||. ....||. 
eaGPivvHcsaGvgrtGtyivldtllkqiqqenav.nvfgflkhiraq.RnflvqteEqYiflhdallea
subfamily_PTPN1_pd Subfamily PTPN1 277-508 7.8e-51 167.5 In-house 25-264 (290) alignment 
Range on Protein: 277-508
Range on HMM: 25-264/290.0
TAFNQPVNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRN
.. ..| |...||| ..   | ||..|.    ....||| |. .  . .|| |||||||  .| . ||.|.|.... |.||| .. | .. |||.|.|..
reaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

AH-CCLQFD--KMSVSYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR------STPPVIHCSAGVGRSGTLMA
 .  .|...  |..| .    ...  .   |.|      ||| |.|. .  |||. || |   .|| | |.|          |.|||||||.|||||.. 
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

VEIALQSIHSHFT--LPDIKQIVSHLRVTgRAASVQTLQQYMLIW
|.  |  |. .      |||. . .||   |   .|| .|  . .
vdtclvliekkddlssvdikkvllelrky.rlGliqtadqlrfsy
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 252-513 8.8e-51 167.5 In-house 14-274 (515) alignment 
Range on Protein: 252-513
Range on HMM: 14-274/515.0
SQKMTLddFKQEFSNLPGdPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQEN
... ||  | .|| .||| |     |  .. .| ||||| ||  .| .||.|.|. ..   ||. | ||.|    . || .|||.| .  ||||...|||
nrhttl..fseefhdlpg.pniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqen

TTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----T
.|.|.|. .  | .. ||..|.|      ..| ...|.          .  .|..  . ..| .| . ..||||  ||  .  .||......|       
vttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyth

PPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD
| .||||||||| | .....  .  ..      |. ..|  .|   |   ||| .|| .|. ..|.
pliihcsaGvGrtGvvisidsvvahaktt.rmvdvfnfvtnirq.krpylvqtqeqyafiygavle
subfamily_PTPN13_pd Subfamily PTPN13 254-513 2e-50 166.6 In-house 7-267 (273) alignment 
Range on Protein: 254-513
Range on HMM: 7-267/273.0
KMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpnkNSTDYIHANYIRSPFLKR--GYILTQGPKKETRADFWRMIWQEN
|.  .. ..|| .|    | | |.  ..  |..|||| |.   | .||.|.     ... || |..|. |  |    ||..|||  || .|||.|.|. .
kldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg.....deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqk

TTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDK-MSVSYEDSTVNKSLVTTRLNLS--YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR---
.. |.|. .  |... ||  |.| ...  |.    . |. .. .  ...|  .|...    ||.| ..|  . .||| .|| |.. .|......|     
aeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtd

STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
..| |.|||||.||||||......|. |.    . |.|.|| .||   | . ||| .||....|..|.
agPivvhcsaGiGrsGtlitidvvlglierdkef.dvkeivrklreq.rqgvvqtkdqyifvykaile
subfamily_PTPN3_pd Subfamily PTPN3 263-510 2.1e-50 166.2 In-house 20-270 (280) alignment 
Range on Protein: 263-510
Range on HMM: 20-270/280.0
EFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIR----SPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
.| .|    |.  ..| ..| | .|||| .|   |. ||.||    ...|||| |||.     |  |   || |||| ..| .|||.|.|..... ||||
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

CQFTETNREKCAEYFPRNAHcCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA----RSTPPVIH
 . .|  | || .|.|.. .  |.. ..||  | .  .|| |.  | |. .   | | |..  . .||| .|| .|. .|......|.    ...| |.|
ttlverGrvkChqyWPeted.eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvh

CSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKV
||||.||.| |...|.||. | ..  .  . .||...|   ||. ||| .|| .. . 
CsaGigrtGvlilletalalieaaepv.ypldivrtmr.dqramlvqtasqykfvCea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 281-517 3.5e-49 162.3 In-house 6-244 (250) alignment 
Range on Protein: 281-517
Range on HMM: 6-244/250.0
QPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREkCAEYFPRNAhcC
.| |..|||| .|  || ||| |.     . .||| | .. .   .. .| |||| ..|  |||||...|....|||| ...|.... . .|.| .    
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..a

LQFDKMSVSYEDSTVNKSLVTTRLNLSYEGET--RLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR-----STPPVIHCSAGVGRSGTLMAVEIALQSI
 .. .. ||  .. .   .....| || . ..  |.. .  .  |||  ||   . .|..|.|..|      ..| ...|||||||||. .|..  |. .
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

HSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVA
.   .. |. ...  ||   |  .|..|.||. .....| . ..
kkekvv.dvfkvikvlrk.drphavesleqyvfvyeiilkalds
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 248-516 5.5e-49 161.4 In-house 14-290 (305) alignment 
Range on Protein: 248-516
Range on HMM: 14-290/305.0
FAMSSQKMTLDDFKQEFSNLPGDPPSDLC-TAFN----QPVNNKKNRYLNIPCLDISRVQLKVMPnknSTDYIHANYIRSPFL-KRGYILTQGPKKETRA
| . .  . .| ...|| .|      |.  .|||      ..  |||| ..|| | | |.|.  .    .|||||||.  |.. .. .| .|||  .|  
fvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtid

DFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVsYEDSTV------NKSLVTTRLNLSYEGETR-LITHWLWKEWPDWQVPGSSEV
.|| |. |..   |||||.  |. . |||.|.|      |..    |  |. .       .  .  | |||.| |. .  . |  | ||||  ||     
efwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgiv.venvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppcklt

MLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
 |..|  ||    | |.|||||.||.||..|.|  |. |      | . ..|  ||   || |.|.  ||. | .|.|.. .
slellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalr.dqrafsiqndvqylfihrvmlnyfl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 254-516 1.5e-48 160.4 In-house 20-280 (315) alignment 
Range on Protein: 254-516
Range on HMM: 20-280/315.0
KMTLDDFKQEFSNLPGDPPSDLCTAFNQpVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTT
  | . |||.. ..||     | .| .   | .|||| ||   | ||||| .. |.. .||. ||.|     || || .|||. ..  ||||....|. .
astkngfkqdyesipggqlhpldvakki.enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedig

AIVMLCQFTETNREKCAEYFPRNahcCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARS----TPP
 |||| .  | ...|. .|.| .    . . |..|.  .  ||. .    |   .. . | .  . .  ||| .|| ..  .... |...       .. 
kivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgai

VIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV
|.||||||||.||.....  |. ..    . |. ...  .|   |   ||...|| .|...||.  |
vvhcsaGvGrtGtfitldavldqaeae.naidvynfitgvrqn.rikmvqvaeqyqfiydalletfv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 245-513 4.6e-48 158.6 In-house 7-281 (290) alignment 
Range on Protein: 245-513
Range on HMM: 7-281/290.0
FKDFAMSSQKMTLDDFKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNS--TDYIHANYIRSPFLKRGYILTQGPKKETRAD
| .| .  ..   . |...|  |     .   |  . . |...||. ||   |  |. |. .....    .||.| ||     |. ||.|||| ..| .|
fgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvd

FWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCClqFDKMSVSY-EDSTVNkSLVTTRLNLSYE---GETRLITHWLWKEWPDWQ-VPGSSEVMLK
||..||||..|.||||.. .| ...||  |.| .      ....|.   ...|.| . ....|..  .   |... .|..  . |..   |.  . ..| 
FWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillv

ILRKIR----ARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
| . ..       |. |.|||..||||....|......  ..     |. |.. ..|.  .  |||| ||| .| ...| 
ieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvi.dvfqvlksqRiq.kpgsvqtvqqyqgifqivlt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 282-513 8e-47 154.5 In-house 31-264 (283) alignment 
Range on Protein: 282-513
Range on HMM: 31-264/283.0
PVNNKKNRYLNIPCLDISRVQLKVMPNknstDYIHANYIR---SPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAh
  |..|||. .|   |  ||.||  ..    ||| | .|    |   ...|| .|.| ..|. |||.|...|. |||||| .. | .|.||. |.|..  
denkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.

cCLQFDKMSVSYEDSTVNKSLVTTRLNLSYE---GETRLITHWLWKEWPDWQVPGSSEVMLK---IL-RKIRARSTPPVIHCSAGVGRSGTLMAVEIALQ
   .. .. |. .. | ..|..   | | ..    .| |..|.   .| ...     . ..|   .   . . . .| |.|||.|.||.....|.  ...
.sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvk

SIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
 . .. .. |. ..|  .|.  |   ||||.||.|. .. |.
dalte.svvdvfavvkimreq.rmmavqtldqyklvhelvle
subfamily_PTPN23_pd Subfamily PTPN23 283-512 1.7e-46 153.3 In-house 42-277 (288) alignment 
Range on Protein: 283-512
Range on HMM: 42-277/288.0
VNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCL
.. .|||. .|   | .||.|.    ..  ||| | ....       .| ||.|...| .|||.|.... .  |||| . .|....|...|.| .     
lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

QFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA--------RSTPPVIHCSAGVGRSGTLMAVEIALQ
.|...||. .. .  .  |   |.|. ..  ... ..|  ...||.  || | |..|..| ....          || |.||||||||.|..  |  |..
kfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavr

SIHSHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLL
 .. .  |.|| |.||.||   |  .||. .|.   ... |
elekgnglldiiqvvsrlreq.Rrfmvqekeqlkfsyeavl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 257-515 1.8e-46 154.0 In-house 33-294 (319) alignment 
Range on Protein: 257-515
Range on HMM: 33-294/319.0
LDDFKQEFSNLPGDPPSDLCTA-FNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAI
|  .. || ...  ...    .  | . |  |||. ||   | ..|.|. .  .. .||| | ..     |  || .|||...| ||||||||. |...|
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLCqftetnREKCAEYFPRNAHCclQFDKMSVSYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIR------ARS
|.|       ..||..|.| ..    . ... |. .  .  .  |   ..||    | . | || . .. |||  || ..  ......|.|         
vllt......kdkcsqywplkivi..keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhr

TPPVIHCSAGVGRSGTLMAVEIALQSIHsHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD---FG
.. |.||||||||.|. ..... |. .. .    |. ..|  ||   |   || | ||..|.  ||.   ||
anivvhcsaGvGrtGvyivldvlldrmk.eekqvdvynfvrdlrq.qrntlvqdlvqykfiysalleehlfg
subfamily_PTPN14_pd Subfamily PTPN14 260-514 3.7e-46 152.5 In-house 25-295 (300) alignment 
Range on Protein: 260-514
Range on HMM: 25-295/300.0
FKQEFSNLPGDPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMpNKNSTDYIHANYIRSPF--LKRGYILTQGPKKETRADFWRMIWQENTTAIVM
  .|. ..|      |... . |.|..|||. ..   . .||.|.   ..|||.|| |  |. .    .| || .||| . |  |||.|.|..... |||
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelspt.kenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

LCQFTETNREKCAEYFPRN--AHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSY--EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRA---R-----
| . .|  .||. .|||..   .  ..|.|  |. . |.  .|..|| |.| .   .| | . |  ...||| .||   . .|. |.....   .     
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

-----STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
     . | ..||||||||.| |. ... .....   .. |||.....|| . |   |||| ||  ..|||. .
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneei.dikkvlarLr.eqrmllvqtlaqYkfvYkvliky
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 278-515 1.4e-45 151.0 In-house 19-258 (284) alignment 
Range on Protein: 278-515
Range on HMM: 19-258/284.0
AFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCqftetnREKCAEYFPRNA
  | . |  |||. .|   | ..|.|. .  .. .||| | .|     |  || ||||...| ||||||||. |...||.|       ..||..|.| ..
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki

HCclQFDKMSVSYEDSTVNKSLVTTRLNLSY---EGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIR------ARSTPPVIHCSAGVGRSGTLMAVEI
    . ... |. .  .  .  |   ..||    | . | |. . .. |||  || ..  ......|.|         .. |.||||||||.|. .....
vi..keerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv

ALQSIHsHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD---FG
 |. .. .    |. ..|  ||   |   || | ||..|.  ||.   ||
lldrmk.eekqvdvynfvrdlrq.qrntlvqdlvqykfiysalleehlfg
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 245-514 2.3e-45 149.8 In-house 7-277 (287) alignment 
Range on Protein: 245-514
Range on HMM: 7-277/287.0
FKDFAMSSQKMTLDDFKQEFSNLPG-DPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADF
| .|. . ..   ..||. |  |   .   |  |    . |..|||. .|   |  || ||    ..  ||| | .| .   |. .|....|  .|  .|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHccLQFDKMSVSYEDSTVNKSLVTTRLNLSYEG---ETRLITHWLWKEWPDWQ-VPGSSEVMLKIL
|..|...| |||||||| .|...|.| .|.| ..   . . . ...  . .||.. .  .|..  ..   ... .. .   .|..   |.    ..| | 
WkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

RKIRAR----STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
......     |. |.|||..||||....|......  .   .. |. |.. . |.  .  |||| .||. | ...| .
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGvi.Dvfqvlksqriq.kpgsvqtveqykfindivley
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 247-514 6.7e-45 148.5 In-house 14-283 (297) alignment 
Range on Protein: 247-514
Range on HMM: 14-283/297.0
DFAMSSQK-MTLDDFKQEFSNLPGDPPSDLcTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSpfLKRGYILTQGPKKETRADFWR
|||   || .  | |..||  ||        |  .. || .|.|| ||   | |||.|... .. . ||. | ....   |  .| || |.|.| ||||.
dfatlvqknrhtdvfseeflclpeaniqpq.tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg..nkhrlittqmPmkatvadfWa

MIWQENTTAIVMLCQFTETNReKCAEYFPRNAHCClqFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPG--SSEVMLKILRK
|...|....|||| .  |... ||| |.. ..     | ..||  .  .  .  .   |... .    .|..  . . |||| .|.   | . .||..  
mvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklise

IRA-----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
.|       ..| ..||.||||| | |....  .  .. . .. || ..|..||   |   ||| .|| ......|..
vrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekev.difglvkklr.qerpylvqtkeqykfvyvavlea
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 255-516 1.3e-44 147.4 In-house 16-272 (288) alignment 
Range on Protein: 255-516
Range on HMM: 16-272/288.0
MTLDDFKQEFSNLPGDPPSDLCTAFNQpvNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTA
....  |.|. . | . . |  ..| .  |  ..|| |.|. ||.||.|.     ..  ||.|| . |   ||  | .| | . |   .|.|. ...   
iaveglkkeyrdspneasidiidsfia..nptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdvey

IVMLCQFTETNREKCAEYFPRNAHCCLQFDKMS--VSYEDSTVNKSLVTTRLNLSYEGETRL-ITHWLWKEWPDWQVPGSSEVMLKILRKIRARSTPPVI
|||||.. |  .|| ||||| .     .. ..   |  . . ..| .. . |. | |||..  . .  ..||.|  || .    |..|  ...   | |.
ivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivv

HCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV
|.||||||.|||. . |||.|. ..  |  |......||   |  ..|| .||. .....|.  .
hssaGvGrtgtlililialeslrlddfl.girsllaklree.rfkaiqtemqylyvhrcvleell
subfamily_egg_pd Subfamily egg 275-515 1.7e-44 146.7 In-house 32-270 (307) alignment 
Range on Protein: 275-515
Range on HMM: 32-270/307.0
LCTAFNQpVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETnrEKCAEYFP
| ||...  | .| |   ..| | |||.|..   . . |.||||...   |   .||.| | |.|  |||||..||.   ||||    |.  |.|  |.|
lttaasd.nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

RNAHCCLQFDKMSVSYEDSTVNK----SLVTTRLNL-SYEGETRLITHWLWkewpDWQVPGSSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIA
.     |..   |.  |   |..     .  |.|.|   . | | . || .    |..  .     |..|||.|  |.| |...  || ...||.|.|||
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg....dvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieia

LQSI-HSHFTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFG
| |.     |   ... |  ||   |  ||..  .|.......| | 
llsllrGpitkslvlravvflrlr.rrlsvesvllylfvyrlvlfff
0049772 (Phosphotyrosine protein) phosphatases II 271-515 4.7e-43 143.5 In-house 33-280 (314) alignment 
Range on Protein: 271-515
Range on HMM: 33-280/314.0
PPSDLCTAFNQPVNNKKNRYLNIPCLDiSRVQLKVMPNKNsTDYIHANYIRSPflkRGYILTQGPKKETRADF----------WRMI--WQENTTAIVM-
.|.  ........| .|||||.|.. | .||.|. .|... .|||.|.|....   . .| ||||...|  ||          |||.  .. |.  ||| 
lpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------LCQFTETNREKCAEYFPRNAhcclqfdkmSVSYEDSTVnkslvttrlnlsyegeTRLITHWLWKEWPDWQVPgSSEVMLK
                    |..... . | .|....            .. |... .                .||. ..|.  .||...| ..| ...
rdevladelsrLdaAlgKtpllildgngneptaadlellk.........eelydpelf................erlgikylripvpDgsap.lledfde

ILRKIRA--RSTPPVIHCSAGVGRSGTLMAVEIALQSIhsHFTLPDIKQIVSHLRV-TGRAASVQTLQQYMLIWKVLLDFG
.|. |..  . .| ..||.||.||.||.... . .     ...| .. . |   |    .  ....|.||  |...||.. 
flefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll..gvsleealedvrlkRpinpnpgfieqleqyefilealleyl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 237-525 1.1e-42 140.7 In-house 6-300 (310) alignment 
Range on Protein: 237-525
Range on HMM: 6-300/310.0
TREAYRKLFKDFAMSSQKMTLDDFKQEFSNLPGDPPSDL-CTAFNQpvNNKKNRYLNIPCLDISRVQLKVMPNKnSTDYIHANYIRSPFLKRGYILTQGP
    | | ...| ....|. .. . ... .|  .  | |   |...  . .|||| .. ||| |||.||.   .   |||||||... .|.  .| .|||
hhlkylkalenfiiateklgieglvkqyrkldakqdssltyeaykk..ymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgp

KKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPR----NAHCCLQFDKMSVSYEDSTVNKSLVTT-RLNLSYEGE-----TRLITHWLWKEWPD
 . |  ||||||.|| . .|..||. .|  | ||  |.|     ... |..  ..| | |.  . .  ||    |.  . .        ..   | .|||
lqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpd

WQVPGSS--EVMLKILRKIraRSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVAYKQITE
  ||      |  ..| ..  |  | |.|||||..| ....|...... ..      |.......|.   ||  .||  ||..| .| . |  . ....|
rgvpdekchtvpqrllaqv..rhgpcvvhcsagkdrlyvvvalklkidkldrg.lkvdaeevktellk.sraiciqtelqyliidrvriifargetevae

EL
..
ki
0041856 (Phosphotyrosine protein) phosphatases II 284-513 1.4e-42 140.7 In-house 1-169 (182) alignment 
Range on Protein: 284-513
Range on HMM: 1-169/182.0
NNKKNRYLNIPCLDISRvqlkvmpnknSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCqftetnrekCAEYFPrnahcclqf
| .|||| .|.. | ||            |||.||......  . .|.|||| ..| |||.||..... |.||.|.         .  |.|         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

dkmsvsyedstvnkslvttrlnlsyEGETRLITHWLWKEWPDWQVPGsSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSihsHFTLPDIK
                         | ..||....|.  |||. ||   . .|.......... | ..||||||||.||| |  . ..    ...|... 
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl...gvsleeav

QIVSHLRvtgrAASVQTLQQYMLIWKVLLD
. |   |      .|.|..|| ..  .||.
klvrsrR....pgmvitpnqyfflqlalle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 257-514 1.7e-42 140.7 In-house 22-287 (325) alignment 
Range on Protein: 257-514
Range on HMM: 22-287/325.0
LDDFKQEFSNLPGDPPSDLcTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMI--WQentTA
 | | .||  || | .    ..  .| | .|||. |.  || ||| |. . .. |.||| |.|.|.   |  .. .| |. .|  |.||..  |.   ..
qdgfahefgllpsddgiak.kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...cs

IVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNL--SYEGETRLITHWLWKEWPDWQV---PGSSEVMLKIL----RKIRA-
.|..    ... ..|| |.|..     .|  . |.          |  .|..    .|||| .  . .. |.|  |   | .   .|...     ...| 
vvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan

--RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDF
   ||| ..||||||||.|.....  ||. .  .  . || . | .||   | . |.|  ||.||.. | ..
tkastpilvhcsaGvGrtGvfislysalakvieesrv.difgfvkklrk.drpsmvetvdqyiliyealvea
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 243-533 3.6e-42 139.3 In-house 5-299 (439) alignment 
Range on Protein: 243-533
Range on HMM: 5-299/439.0
KLFKDFAMSSQKMTLDDFKQEFSNLPGDPPSDLCTA--FNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETR
. |..     .|   . ||..| ..    |   | |    |  .. |||| ..  .| .|| |. .|    . || ||||.  . .. || |||||||| 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

ADFWRMIWQENTTAIVMLCQFTETNRekcaeYFPRNAHCCL-----QFDKmSVSYEDSTVNKSLVTTRLNLSYegETRLITHWLWKEWPDWQVPGSSEVM
 ||||......|. ||||... |. .     |.| .|..|      . |.  .   . ..    |  . . .     | . .. .  ||| .||  .  .
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdr.nielpnyvirgfkvfnerdtte..kertvlqfhyiawpdknvpaqashv

LKILRKIRA-----RSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDfGVAYKQITEELAE---
|. || | .        | |.||||||||.||..|..|||. ...   . ||| ||. ||   |   ||.| ||..|.. .|.  . | .|.  . |   
ldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkv.dikgivkvlrk.qrkqmvqalcqyvfiynavle.divyGdiavtidefkk

KFNATY
.||| .
efnagf
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 287-533 1.8e-40 133.9 In-house 21-279 (290) alignment 
Range on Protein: 287-533
Range on HMM: 21-279/290.0
KNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRgYILTQGPKKET-------RADFWRMIWQENTTAIVMLCQFTETNRE----KCAEYFPR
... |..| .  .|| ||.  .. . ||||||..  |   |  |||| |....         .|| |. ||. . .||||.|.| ...     ||.|.| 
mdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglr.liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

NAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRL-ITHWLWKEWPDWQVPGSSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIH
..   |.|. ..|.  .   .. . | .| . ...|  . .|| | |.| . .|. .. ..|....|..|. || ..||  |. || .| |.... | | 
svgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkia

SHFTLPDIKQIVSHLRVTgRAASVQTLQQYML-IWKVLLDFGVAYKQITEELAE-KFNATY
       ...... ||   ||  ... ...   .  ..| .  ...|..||  | | .| .
etsgsvkledvlkalrkq.ralaitsalelafvdagivllaievldqfaeeetekkakaee
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 259-513 3.7e-40 132.5 In-house 21-234 (392) alignment 
Range on Protein: 259-513
Range on HMM: 21-234/392.0
DFKQEFSNLPGdPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVML
 | .|| .||| |.    |. ....| ||||| ||  .| .||.|.|. . . .||. | ||.|   .. || .|||.  .  |||||..|||.|.|.|.
lffeefhdlpg.pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

CQFTETNrekcaeyfprnahcclqfdkmsvsyedstvnkslvttrlnlsYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR----STPPVIHCS
 .. | .                                             ..| .. . . |||| .||  .  .||......|     . | .||||
tklkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcs

AGVGRSGTLMAVEIALQSIHsHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLD
|||||.| .....  .   . .  . |. ..|. .|   |   ||| .|| .|.  .|.
agvgrtgvvisidsvvahak.ktrmvdvfnfvtnirr.krpymvqtkeqyafiygavle
subfamily_PTPRN_pd Subfamily PTPRN 278-509 3.4e-38 126.0 In-house 50-286 (297) alignment 
Range on Protein: 278-509
Range on HMM: 50-286/297.0
AFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPF-LKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRN
. ... | ||||. ..   | |||.||   .....||| |  |      .  || ||||  .| ||||.|.|.. .. ||.|.. .|.. ..|..|.| .
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

AHCCLQFDKMSVSYEDSTVNKSLVTTR-LNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKI----RARSTPPVIHCSAGVGRSGTLMAVEIALQ
 .   .. .. .  |    .  || .  |      ||| .| . .  ||. .|| |.  .|.  ||.    | ||.| |.|||.|.||.|. ..... |.
GsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvln

SIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWK
 .       ||   . |||   |.  |.| .|. ....
rllkGvkeidiaatlehlr.dqrpglvktkdqfefalt
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 283-523 1.1e-37 124.4 In-house 49-284 (301) alignment 
Range on Protein: 283-523
Range on HMM: 49-284/301.0
VNNKKNRYLNIPCLDISRVqlKVMPNKNSTdYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQ
....|.|| ..||   . |  .|. . .    ||||.| ..   . .| |||| |.|. ||| |. | .   ||||.|. | . |||.||.| . .  |.
lpkdkhryptvPckPstav..evivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

FDKMSVSY--EDSTVNKSLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHF
 .. ..    ... .||...  .|..     . .|| .||. ..||.| .|| |   . ...  ..    | |.|||||.||| .... |.  . .... 
igrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadp

TLpDIKQIVSHLRvTGRAASVQTLQQymLIWkvlLDFGVAYKQITE
|. .... . |||   |  .||| .|  | |   . .|  |. | |
ti.eltealkhlr.ehrwngvqtnsq..lyw...mtlGtvyrlike
0051429 (Phosphotyrosine protein) phosphatases II 311-525 2.7e-37 124.2 In-house 3-235 (272) alignment 
Range on Protein: 311-525
Range on HMM: 3-235/272.0
STDYIHANYIRSPFL---KRGYILTQGPKKETRADFWRMiWQENTTAIVMLCQFTETNREKCAEYFP----------RNAHCCLQFDKMSVSYEDSTVNK
 ..||.|...  ..    .. .....|| . | |||||. .... ..||.|.. .| .|.||  | |           ...    . ...| .   ..  
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

SLVTTRLNLS---YEGETRLITHWLWKEWPDWQVPGSSevMLKILRKIRArSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPD-------IKQIVS
  . ..| |.   . ||.| ..|...  |||  || ..  .|..|. ... . | ..|||||..|.||. |. . |. .. .  . |       . ..|.
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeave

HLRVTGrAASVQTLQQYMLIWKVLLDFGVAYKQITEEL
.||    ...||| .||. ....||..  .. .. .| 
elraqr.pgavqteeqylflyeallellrsllsvraey
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 280-512 2.8e-37 123.2 In-house 4-238 (239) alignment 
Range on Protein: 280-512
Range on HMM: 4-238/239.0
NQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSP-FLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAH
.. ||. |||| ||   | ||| |. . |   .||| |.|.|      . || |||  . .  |||||.|||    ||||  . |  ..|| .|.| .. 
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

cclQFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARST----PPVIHCSAGVGRSGTLMAVEIALQS
   .. .. |.   . |    .   . .|  |  | | . .. .  |||  ||  .  .| . |||   |     | ||||||||||.|... ..  |. 
...kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IHSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLL
 . . |. || . |  .|   |   ||| .||..|   .|
akkqktv.difnyvkaire.drphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 281-512 2.9e-37 123.1 In-house 4-237 (239) alignment 
Range on Protein: 281-512
Range on HMM: 4-237/239.0
QPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSP-FLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHc
. ||. |||| ||   | ||| |. . |   .||| |.|.|      . || |||  . .  |||||.|||    ||||  . |  ..|| .|.| ..  
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

clQFDKMSVSYEDSTVNKSLVTTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARST----PPVIHCSAGVGRSGTLMAVEIALQSI
  .. .. |.   . |    .   . .|  |  | | . .. .  |||  ||  .  .| . |||   |     | ||||||||||.|... ..  |.  
..kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

HSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLL
. . |. || . |  .|   |   ||| .||..|   .|
kkqktv.difnyvkaire.drphmvqtseqyvfihlavl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 253-512 5.4e-37 122.1 In-house 10-290 (301) alignment 
Range on Protein: 253-512
Range on HMM: 10-290/301.0
QKMTLDDFKQEFSNLPGDPpSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPN--KNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQE
 ..  ..|......|     .. ||   .  |.. ||. ||  .|  |. || .||  . ...|| |.|| .   |. .| .||| |.| .||||.||||
aakhsnkfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

NTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTT-----------------RLNLSYEGETRLITHWLWKEWPDWQVPGSSE
 ...|||...  |. ..|| .|.|.  .   .| ...|   ...|  . |                   ... . . ... .. .   .||.  |     
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

VMLKI-----LRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFtLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLL
 .|..      |. .    | |.|||..|.|||. ..|.|.|    .     |. |..  .| . .   |.||.||. |..|. 
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaeg.VVdvfqvtkavrrs.kpgaVtTLeqytsiydvid
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 284-512 5.7e-37 122.2 In-house 3-236 (237) alignment 
Range on Protein: 284-512
Range on HMM: 3-236/237.0
NNKKNRYLNIPCLDISRVQLKVMPNKnsTDYIHANYIRSP-FLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHcCLQ
|. |||| || . | ||| ||   ..  .||| |.|...     . || .||| . .  |||.|.|||. . ||||  . | |..|| .|.|        
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.paa

FDKMSVS------YEDSTVNKSLVTTRLNLSyegETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR------STPPVIHCSAGVGRSGTLMAVEIAL
. ...||      . | ||   |...||.|    | |||  . .  |||  ||  .  .|.. ..|  |      |.| .|||||||||.| .. ..  |
ygvltvslkkkeefsdytvrslllskrltlk...evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

QSIHSHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
.  . .  . || . |  .    |   .|| .||..| ...|
rqakek.kvvdiynyvysie.edrpyiiqtkdqyvfihqtil
0043147 (Phosphotyrosine protein) phosphatases II 310-508 2.1e-36 120.6 In-house 3-154 (172) alignment 
Range on Protein: 310-508
Range on HMM: 3-154/172.0
NSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFtetnrekcaeyfprnahcclqfdkmsvsyedstvnkslvttrlNLSYE
...|||.|.|.  ..  . .| ||||  .| ||||||..... |.||.|...                                            . .|
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GETRLITHWLWKEWPDWQVPgSSEVMLKILRKIRA-----RSTPPVIHCSAGVGRSGTLMAVEIALqsihSHFTLPDIKQIVSHLRvtgrAASVQTLQQY
...||. ..|.  |||  || ..|..|..|. |.      .. | ..||||||||.||| |  . |     ...| .. . | . |      .||. .||
llerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lglsleeavalvrekR....pgavqnpsqy

MLIW
... 
rfly
0036282 (Phosphotyrosine protein) phosphatases II 312-508 3.1e-36 120.1 In-house 2-163 (174) alignment 
Range on Protein: 312-508
Range on HMM: 2-163/174.0
TDYIHANYIRSPFLKRGYILTQGPKKetradFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRnahcclqfdkmsvsyedstvnkslvttrlnlSYEGE
.|||.|...      ...|..||| .     ||.|..... |..|||..  | ...||  |.|.                                .| .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

TRLITHWLWKEWPDWQVPGSSEvMLKILRKIRAR-----STPPVIHCSAGVGRSGTLMAVEIALQSIHshFTLPDIKQIVSHLRVTgRAASVQTLQQYML
.||. ..|.  ||| .|| .|. .|.... ..       . | ..||||||||.|||.|  . |. ..   .| |. ..|  ||   |  .||| .||. 
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlq.rpgmvqtpsQyrf

IW
. 
ly
subfamily_CG7180_pd Subfamily CG7180 260-517 4.6e-36 119.0 In-house 19-292 (296) alignment 
Range on Protein: 260-517
Range on HMM: 19-292/296.0
FKQEFSNLPGdPPSDLCTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLC
.|.|.   |    .. | .  .  | .|||. ..   |  || |. .  ....||| | |. |   |. || |..|||||  .|||....|.. |.|.|.
yklelkltpr.leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

QFTETNReKCAEYFPRNAhcCLQFDKMSVSYEDST-----------VNKS-LVTTRLNLSYEGETRLITHWLWKEWPD-WQVPGSSEVMLKILRKIRA--
. .. .. .. .|.| ..    |. .. | .  .            ..|  . .|  .   . |||....  ..||.   .|| |.. .....|..|   
ktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwr

-R------STPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFGVA
 .        | |...| |..|||  .|....|. .. .  . |. . |  ||   |   |.. ..|. |. |||.. ..
ekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeev.dvFeavktlrr.sRpqLvenveeYkyiYdvlleavlc
subfamily_ptpA1_pd Subfamily ptpA1 279-481 6.9e-36 118.9 In-house 42-264 (418) alignment 
Range on Protein: 279-481
Range on HMM: 42-264/418.0
FNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFLKRgYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAH
 ..  |  |||| ||  .. .||||| . .|. .||| ||||   . |. .| ||||  .| ||||||.|..    |||| . .|  | ||  |.| .  
gdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqig

C---------CLQFDKMSVSYEDS--TVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR----------STPPVIHCSAGV
             |   ||   .     .. ..|  . |..||||| ||.. .. ||| ..|  .. . ..|. |  |            | ..||||||
geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRSGTLMAVEIALQSIHSHFTLPD
||.||. .  | .. .  .|   |
grtgtfctavimmkkldhyfkqld
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 260-534 2.4e-35 116.7 In-house 21-297 (312) alignment 
Range on Protein: 260-534
Range on HMM: 21-297/312.0
FKQEFSNLPGDPPSDLCTAFNQpvNNKKNRYLNIPCLDISRVQLKVmpNKNstDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLC
. .|.  .    .   |||| .   .  ||| || | |  |  |    ..|   |||||...       .. |||| ..| . ||..     .|.|..||
ltkeykavgnivsdsectaflk..fkdlnrypniqcwdrgrftlag..den..fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

QFTETNREKCAEYFPRnAHCCLQFDKMSVSYEDST------VNKSLVTTRL---NLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRARSTPPV
 | |   ||||.|        ....   |  |  |        |  .| |.    .   |.   . |. |  |||  .| | .  |..|  ..    | .
gfvedgsekcakyisd.ivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpvi

IHCSAGVGRSGTLMAVEIALQSIhSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGVA---YKQiTEELAEKFNATYR
 ||||||||.|||. .|  . ..  |    ..|..   ||   || ||... ||.   ...|.|  .   ||.  |.   ||. || 
ahcsagvgrtgtlaliesmiaal.rhprkqnvkdsfvllr.kdrarsvrvfpqyvyalrcvleflyskglykr.neqewtkfketya
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 276-516 3.5e-35 116.4 In-house 27-271 (285) alignment 
Range on Protein: 276-516
Range on HMM: 27-271/285.0
CTAFNQPVNNKKNRYLNIPCLDISRVQLKvmpnKNSTDYIHANYIRSPFLK-RGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFP
||      |   ||| .. |.. .|| ||    .   |||||...| |      || ||||  || .|||.||.||. . ..||| . |   |||| |.|
ctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp

RNAHCCLQFDKMSVSYEDS-------TVNKSLVTTRLNlSYEGETRLITHWLWKEWPDWQVPGSSEVML---KILRKIRARSTPPVIHCSAGVGRSGTLM
 .    ..| |  ..  .        |. ..|  .  .     |   . |     |||   |  .  |.   | ..|.  . .| ..||||||||. |..
eklgevvkfgkyeitlteckeeaiagtilnaltvinte.dasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfv

AVEIALQSIHSHFTLpDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDFGV
 .. |   |     . .. .||  .|   |  .||.  |..... ||... .
gidyatirimenpni.emldivremram.rfqavqshmqflflyvvlmeyfi
0046846 (Phosphotyrosine protein) phosphatases II 306-510 2e-34 114.2 In-house 6-168 (176) alignment 
Range on Protein: 306-510
Range on HMM: 6-168/176.0
MPNKNSTDYIHANYIRSPFlkrgYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLqfdkmsvsyedstvnkslvttrln
.   .. |||.||.| ...    .| ||||  .| |||..|..... ||.|.|.. .|..| ||. |.|.     .                        
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

lsyegetrlitHWLWKEWPDWQVPGSsEVMLKILRKIRARS---TPPVIHCSAGVGRSGTLMAVEIALQSihshfTLPDIKQIVSHLRVTGRAASVQTLQ
           ..|.  ||| .|| . | .|..|. || .     | ..|||||.||.||| |  .   .        .. ......|   .  .||| .
...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpe

QYMLIWKV
||  . ..
Qyrflyef
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 258-513 2.3e-33 110.2 In-house 10-275 (287) alignment 
Range on Protein: 258-513
Range on HMM: 10-275/287.0
DDFKQEFSNLPGDPpSDLCTAFN---QPVNNKKNRYLNIPCLDISRVQLKVMPNKnSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTA
|| ..|. .|  |        |    .  . ||||| ..  .| .|| |   ...  .||| |||. |   .  .| .|||   |  ||||.........
ddvdkevdalkeds.esstatfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsas

IVMLCQFTETNREKCAEYFPRNaHCCLQFDKMSVSYEDSTVNKSL---VTTRLNLSYEGETRLITHWLWKEWPDWQVPGS----SEVMLKILRKIR----
.... .  |  | || .|.| . .  ..    ||   | .. .      . ||      |.|..    . .|||  .. .       .|.. ..|     
vitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielard

-ARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLD
 .   |.|.|...|.||||.|.|. . ..   .     |. ..| .||   ||| ||.  |. |... |  
asevGPlvvhddvGiGrsGillatlvlvsrledl.Grvdvaavvirlrey.raalvqavvqlrllyealvt
0049260 (Phosphotyrosine protein) phosphatases II 326-508 5.6e-31 102.7 In-house 8-143 (152) alignment 
Range on Protein: 326-508
Range on HMM: 8-143/152.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFprnahcclqfdkmsvsyedstvnkslvttrlnlsyegetrlitHWLWKEWPD
.. .| ||||  .| ||||||... . |.||||....| ...||..|.                                           ..|.  |||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpD

WQVPGSSEVMLKILRKI----RARSTPPVIHCSAGVGRSGTLMAVEIALqsihSHFTLPDIKQIVSHLRvtgrAASVQTLQQYMLIW
  || .|...| .|. |    . .. | ..||||||||.|||.|  . |     ...| .. . |   |      .|.. .|.... 
hgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml....lgvsleeavalvrekR....pgavpnpgqlrfly
0051082 (Phosphotyrosine protein) phosphatases II 312-511 3.6e-29 96.7 In-house 3-149 (151) alignment 
Range on Protein: 312-511
Range on HMM: 3-149/151.0
TDYIHANYIRSPflkrgYILTQGPkketRADFWRMIWQENTTAIVMLCQFTETNreKCAEYFPRNAhcclqfdkmsvsyedstvnkslvttrlnlsyege
.|||...|. .      .....||     |||........ ..||.|.. .|..  .|.||.|..                                   
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

tRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR-STPPVIHCSAGVGRSGTLMAVEIALQSihshftlPDIKQIVSHLRVTGRaASVQTLQQYMLIWKV
 . ..|. .  ||| ..| | . .|..|.....  . | ..|||||.||.|||.|. . |.         .. ......| .    .||. ||.... ..
.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrp.gvvqpnqqflfqlfa

L
|
l
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 282-433 6.6e-29 95.7 In-house 31-184 (297) alignment 
Range on Protein: 282-433
Range on HMM: 31-184/297.0
PVNNKKNRYLNIPCLDISRVQLKVMPNknSTDYIHANYIRSPFLKR--GYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHC
.   .|||| .|   | .||.|.  .    .||| |.|.  |  .    |||.||| ..|  |||.......  .|||.... |  |.||| |.|.    
nsslrknryrdilatddtrvkllrvit..erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

CLQFDKMSVSYEDST---VNKSLVtTRLNLSYEGETRLITHWLWKEWPDWQVPGSSE
 |.  .. | .  ||    ..  . | |.| |  |.| ..|  .  |||  ||   |
rlkagdvvveflsstsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdle
0044763 (Phosphotyrosine protein) phosphatases II 295-507 1.1e-28 95.4 In-house 1-163 (178) alignment 
Range on Protein: 295-507
Range on HMM: 1-163/178.0
CLDISRVQLKVMPNKNSTDYIHANYIRsPFlkrgYILTQGPKketrADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHcclqfdkmsvsyedst
.|| .|| |  ... ...|||.|..|  |.    ..|.. |     ||......... |.||.|.. .| ...|| .|.|..|.                
pldrtrvllsnleglersdyinaseil.pg....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

vnkslvttrlnlsyegetrliTHWLWKEWPDWQVPGSSEVMLKILRKIR----ARSTPPVIHCSAGVGRSGTLMAVEIALQSihsHFTLPDIKQIVSHLR
                      ..|.  .||. || ..| .|.... |.     .  | ..||||||||||||.|  . ..    ...|... . |   |
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl...glsleeaielvrerR

vtgrAaSVQTLQQYMLI
       |..  |.  .
....p.ivpnpgqlrqL
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 253-516 2.1e-28 93.6 In-house 21-286 (302) alignment 
Range on Protein: 253-516
Range on HMM: 21-286/302.0
QKMTLDDFKQEFSNLPGD-PPSDLCTAFNQpvNNKKNRYLNIPCLDISRVQLKVMPNknstDYIHANYIRSPFLKRGYILTQGPKKETR---ADFWRMIW
....    |.|| ..     . . |.|| .  | |||.  ..|.||  .|.|.  |.    .|..|  .  | |.|  ||.| ||...    ..||||..
ksldtaevkkefkkidtmkvdlekCkafkk..nlkknqsedvpildsnlvkleaepd....syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvf

QENTTAIVMLCQFTETNReKCAEYFPRNAHCCLQFDKMSVSYEDstVNKSLVTTrLNLSYE------GETRLITHWLWKEWPDWQVPGSSEVMLKILRKI
||. . .|.| .  | ..    |.||...   ....|| |      |.|.  ..  ....|       .. |..  . . |.. .|| .   . |   |.
qekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk..Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv

----RARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFGV
       . . ||    |.|| |..... .|.......   | ||.||  .| . |...|..|.||. .. .|| .. 
fakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiR.sqRpravdslkQyvslyialllyik
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 327-515 2.8e-28 93.7 In-house 35-221 (255) alignment 
Range on Protein: 327-515
Range on HMM: 35-221/255.0
RGYILtqgpkkeTRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDsTVNKSLVTTRLNLSYEG---ETRLITHWLWKEW
  |.|       | . |...| | .|. .|||| |.| ..||| .||| .    |.. ...|.  . .... .. |.  .|. |   .|. ..|. .| |
nlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGW

PDWQVPGSSEVMLKILRKIRArSTPPVIHCSAGVGRSGTLMAVEIALQ----SIHSHFTL-PDIKQIVSHLRVTGRAAsVQTLQQYMLIWKVLLDFG
.. . |  .. .|.||. .|  | . |.|||.|.||| ... .|.. |    |..   |   | .... .|| . ..| ..|  |  .   ..||. 
ieknaPelareilnilkvvrd.sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkra.ihtPlqlafsilmvldlv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 235-512 3.1e-27 90.0 In-house 3-276 (303) alignment 
Range on Protein: 235-512
Range on HMM: 3-276/303.0
EETREAYRKLFKDFAMSSQKMTLDDFKQEFSNLPgdpPSDLCTAFNQpvNNKKNRYLNIPCLDISRVQLKvmpnknSTDYIHANYIRSPFLKRGyILTQG
|| .. .. | |..     ... ..|..  | ||   ||     | .  | .|||. .. ||| |.|.|        . ||||.|.     |.  |||| 
eekkqkwkllakrtldedaniavnefekvvsylp...psvsknqfvk..nmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltql

PKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHcCLQFDKMSVS---YEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPDWQVPGS
|   | ||||.|| ...   ...|   .| ..      ||||    |.|.. |.    .    . .  |   | .|      ..    .|.||  ..|. 
plshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsd

-SEVMLK-------ILRKIrARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
 |  ..|       .|||  . |||.|    .|.||.||.   | |  |.||  .  |. . .  .|  ||  .|| | |. ... .| 
gspkfvkqiwqlqsvlrky.sdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvr.ngrlhavqnlsqfsvvytlla
subfamily_CG42327_pd Subfamily CG42327 260-444 8.9e-26 85.3 In-house 7-192 (319) alignment 
Range on Protein: 260-444
Range on HMM: 7-192/319.0
FKQEFSNLPgdppSDLCTAFNQPVN-NKKNRYLNIPCLDISRVQLKVMPNKNSTDYIHANYIRSPFL-KRGYILTQGPKKETRADFWRMIWQENTTAIVM
  .|| .||      .  | . ||  ..|.|..|.  |  .|| |. ....... |..|.|.| .   .  || .| . ... .||||..|. ..  || 
vaeefrdlP....qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivq

LCQFTETNREKCAEYFPRNAHC--CLQFDKMSVSYEDSTVNKSLVTTRLNLS-Y-EGETRLITHWLWkEWPDWQVPGSSEVMLKILRKIRA
|..  |   ..||||.| ..       . .. |.  .  |..  ... | |    . |.| .||. . .|.. .|| . . .. .| ..|.
ltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 284-517 9.1e-25 82.1 In-house 33-259 (267) alignment 
Range on Protein: 284-517
Range on HMM: 33-259/267.0
NNKKNRYLNIPCLDISRVQLKVMPNKnstdYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNrekCAEYFPRNAHCCLQF
|...||. .    | .|| |.   .     || | |. .   |. .|.||.| | | .||. .| ... . ||.| .  . |      ..| .   . ..
nqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakky

DKMSV--SYEDSTVNKSLVTTRLNLSYEGeTRLITHWLWKEWpdwQVPGSSEVMLKILRKIRAR------STPPVIHCSAGVGRSGTLMAVEIALQSIHS
. ..|  | |    .  ..|  |..  |  .. .| . .|.|   ..    .  || |  | |.      . | |..||.|||||||.. ..  |. .  
qdltvehslekeendyqiitlelkfknes.ahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakt

HFTLpDIKQIVSHLRVtGRAASVQTLQQYMLIWKVLLDFgvA
  .. || . . ..|   | . |.|...|. | ..| ..  |
egvs.difdflrkirs.qriglvdtkeryiyihellaey..a
PTPc_DSPc_SM00012 415-512 6.2e-24 79.6 In-house 2-104 (105) alignment 
Range on Protein: 415-512
Range on HMM: 2-104/105.0
ITHWLWKEWPDWQVPGSSEVMLKILRKIRARST------PPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIW
..|  ...||| .|| .|. .|..||...   .      | |.||||||||.||..|..|.||..... . .||.|||..|| . |. .|||..||. . 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelr.kqRpgmvqteeqylfly

KVLL
..||
rall
subfamily_hpo-7_pd Subfamily hpo-7 339-514 8e-24 78.9 In-house 46-226 (263) alignment 
Range on Protein: 339-514
Range on HMM: 46-226/263.0
TRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDSTVnKSLVTTRLNLSYEG---ETRLITHWLWKEWPDWQVPGSSEVM
| . |...| | .|. .|||| |.| ..||| .||| .    ... ...|.  ..   . |. |.  ||. |   .|. ..|. .| |.. . |  .. .
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LKILRKIRaRSTPPVIHCSAGVGRSGTLMAVEIALQ----SIHSHFTL-PDIKQIVSHLRVTgRAASVQTLQQYMLIWKVLLDF
|.||.  |  | . |.|||.|.|||     .|.. |    |..   |   |  ... .|| . |.....|  |      ..|||
lnilkvar.nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrss.rkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 334-507 3.6e-23 76.4 In-house 98-280 (302) alignment 
Range on Protein: 334-507
Range on HMM: 98-280/302.0
GPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYED-------STVNKSLVTTRLNLSYE----GETRLITHWLWKE
 |||.|.  .| .| | |.. .| ||.| | . .|||||.  .    |.| . .|   .        |  ||..   ...  |       . .   ..  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDWQVPGSSEVMLKILRKIRARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLI
|||   |  ..  |.||.   .  .  ..||||||||.|||.|.   .|    .    |. .||  .|   |  .||. || . .
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskk.kvtdllsivlpvrq.cryGavqdeqqliyl
0048076 (Phosphotyrosine protein) phosphatases II 401-510 4e-17 57.7 In-house 31-138 (145) alignment 
Range on Protein: 401-510
Range on HMM: 31-138/145.0
TTRLNLSYE--GETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR---STPPVIHCSAGVGRSGTLMAVEIALQsihshFTlPDIKQIVSHLRVTgRA
|| |||..|  ...||....|.  |||..|| ..| .|..|. |..      | ..||||||||.|||.|  . |.     .   .. ... ..|   | 
ttvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleealelvrsq.rp

ASVQTLQQYMLIWKV
 .|.. .|.  . ..
gavpnpgqlrflyef
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 326-510 5.7e-17 56.5 In-house 3-198 (198) alignment 
Range on Protein: 326-510
Range on HMM: 3-198/198.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTeTNRE-KCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS----YEGETRLITHWLW
.| || || | .|| ||||.|.|.  .  |||. .    |.|   . |.|     . ..  .||. .  |..   . | | |.        || |.|. .
qrryiatqhplretladfwqmvwetgsghivmvnddq.knkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

KEWPDWQVPGSSEVM------LKILRKIR-ARSTPPVIHCSAGVGRSGTLMAVEIALQSI-HSHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKV
  | .   |  .  .       .. .|    . .| ..||| | | .| ..|..| ..|   |. .. |. ..   ||   |   . .||.| .|..|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrq.arcgiisslqhynfiyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 326-510 6.2e-17 56.4 In-house 4-199 (199) alignment 
Range on Protein: 326-510
Range on HMM: 4-199/199.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTeTNRE-KCAEYFPRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLS----YEGETRLITHWLW
.| || || | .|| ||||.|.|.  .  |||. .    |.|   . |.|     . ..  .||. .  |..   . | | |.        || |.|. .
qrryiatqhplretmadfwqmvwetgsghivmvnddq.knkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

KEWPDWQVPGSSEVM------LKILRKIR-ARSTPPVIHCSAGVGRSGTLMAVEIALQSI-HSHFTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKV
  | .   |  .  .       .. .|    . .| ..||| | | .| ..|..| ..|   |. .. |. ..   ||   |   . .||.| .|..|
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrq.arcgiisslqhynfiyqv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 286-377 6.6e-17 56.2 In-house 49-154 (350) alignment 
Range on Protein: 286-377
Range on HMM: 49-154/350.0
KKNRYLNIPCLDISRVQLKV--------MPNKNSTDYIHANYIRSP----FLKRG--YILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAE
 |||| ||   . |||.||             .. ||| |||.. .      . .  || ||.| ..|  ||...| . . . |..| .  | |.||| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YFPRNA
|... .
YWqegs
0048179 (Phosphotyrosine protein) phosphatases II 400-507 1.3e-16 56.1 In-house 34-137 (144) alignment 
Range on Protein: 400-507
Range on HMM: 34-137/144.0
VTTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVMLKILRKIRAR---STPPVIHCSAGVGRSGTLMAVEIALqsihsHFTlPDIKQIVSHLRVtGRAA
.. . .  .| ..| ....|.  |||..|| ..| .|..|. |..    . | ..||||||||.|||.|  . .     ..   ...... ..|   |  
inlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrs.rrpg

SVQTLQQYMLI
.|.. .|.. .
avpnpgqlrfL
subfamily_eak_pd Subfamily eak 296-435 3.7e-15 50.1 In-house 63-201 (332) alignment 
Range on Protein: 296-435
Range on HMM: 63-201/332.0
LDISRVQLKVmPNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCAEYFPRNAHCCLQFDKMSVSYEDStV
 |   |.|     .|   || |  .  . . | ||||  ....    ||.|. .... |||.| .  | . ||   ||| ...  |.| .. |   .  |
ydrylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef.v

NKSLV-TTRLNLSYEGETRLITHWLWKEWPDWQVPGSSEVM
... . |  | ||   ||  . |.    | . ..|   . .
krniletrllelskGnethrvlhykvfGwtettlpkyedfl
subfamily_CG42327_pd Subfamily CG42327 444-515 7e-15 49.5 In-house 245-315 (319) alignment 
Range on Protein: 444-515
Range on HMM: 245-315/319.0
ARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDFG
 .  | |.||| ||||.|...| .||..|.       || |.||..|  .|| .|.| .|| .|.|||  . 
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvr.rdrasavltkeqyefiykvlseya
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 437-512 5.5e-14 46.7 In-house 219-292 (297) alignment 
Range on Protein: 437-512
Range on HMM: 219-292/297.0
KILRKIRARSTPPVIHCSAGVGRSGTLMAVEIaLQSIHSHFTLPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLL
. ||    |... ..|||||||||| ..  .. . ..  .  .||.. |.|.||   ||  ||||.|. |.... |
eslraemprnayllvhcsaGvGrsGvvvlsdv.ilaklrkkripdvaailsilr.eqrarlvqtleqfellydavl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 401-513 7.4e-10 32.7 In-house 75-192 (440) alignment 
Range on Protein: 401-513
Range on HMM: 75-192/440.0
TTRLNLSYEG--ETRLITHWLWKEWPDWQVPGSSEVMLKILRKI-----RARSTPPVIHCSAGVGRSGTLMAVEIALQSIHSHFTLpDIKQIVSHLRVtG
.  .| ||    |.| . .. .. |||  ||  .  .||... .     .| . | ..|||||.||.| ..||.  |.  .    . ||  ... .|   
sdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqi.difsfinsmrn.n

RAASVQTLQQYMLIWKVLLD
|   ||| .|| .. ...|.
rpqmvqtpeqyafvheavle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 326-426 9.1e-10 32.4 In-house 235-331 (440) alignment 
Range on Protein: 326-426
Range on HMM: 235-331/440.0
KRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFtetNREKCAEYFPRNAHCcLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWLWKEWPD
|  .| || |   |  ||||.. . . ..|.|| |.   |   |. |.| |.   . |  ..| .  |   . .    |.| |  |   |  .  . || 
knafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrs.vtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwpt

W
|
w
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 270-360 2.9e-08 27.6 In-house 24-118 (347) alignment 
Range on Protein: 270-360
Range on HMM: 24-118/347.0
DPPSDlCTAFNQPVNNKKNRYLNIPCLDISRVQLKVM-----PNKNSTDYIHANYIRSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQ
  ||. .|. .   . .|||  .    | .|| |        .  ..  || | .|.    .. ||||| |  .|  |||.|.   . | .| . .
yspsk.ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 444-514 3.2e-08 27.7 In-house 260-343 (350) alignment 
Range on Protein: 444-514
Range on HMM: 260-343/350.0
ARSTPPVIHCSAGVGRSGTLMAVEIALQ------SIHSHFT--------LPDIKQIVSHLRvTGRAASVQTLQQYMLIWKVLLDF
|||.| ..|||||||| |||....  |.       .  ...           |..|| .||   |   ||.|.|.. |.. || .
arsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelr.kqrismvqnldqfifiYeallfy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 287-376 4.4e-08 26.8 In-house 51-156 (349) alignment 
Range on Protein: 287-376
Range on HMM: 51-156/349.0
KNRYLNIPCLDISRVQLKVMPNK--------------NSTDYIHANYIRSPFLK--RGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETNREKCA
|||| .|   . |||.||  ..                  ||| |||.. . ..  . || || |   |  ||...|  ..   .. | .  |.. ||| 
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcd

EYFPRN
 |.   
iywqel
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 284-385 2e-07 22.7 In-house 29-118 (275) alignment 
Range on Protein: 284-385
Range on HMM: 29-118/275.0
NNKKNRYLNIPCLDisrvqlKVMPNKNSTDYIHANYIRSPFlkRGYILTQGPKKETRADFWRMIWQENTTAIVMLCQFTETnrekCAEYFPRNAHCCLQF
| .|||. |. |.|      ...  .|   ..||| .|.|.    ....| |.  | ||. ...|  |  ..| |    |.       . |..      |
ngeknrftnvtcfd......eildrenqeffvhantfrtpy..gnflisqapndstnadhlhllwiynvqtvvclvlpeea....ggyfvpkegetftsf

DK
.|
qk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 284-369 1.6e-06 21.9 In-house 33-118 (332) alignment 
Range on Protein: 284-369
Range on HMM: 33-118/332.0
NN-KKNRYLNIPCLDISRVQLkvMPNKNSTDYIHANYIRSPFLKRGYILTQGPKK-ETRADFWRMIWQENTTAIVMLCQFTETNREKC
||   ||   . |.| |||.|   |.    |.  |...     |  ||..| | .  |   ||||. . . . |... .  | .. |.
nnmdmnriphlycfdhsrvel..apqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 450-511 1.8e-06 22.2 In-house 1-60 (69) alignment 
Range on Protein: 450-511
Range on HMM: 1-60/69.0
VIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVL
|.|||.| ||.||..|. . .  | |   | ||   | ..|   |   |    .||.|   |
vvhcssGtGrtGtfiaimvemarikse.klvdifnnvqymrk.crpmmvmneneymfihdal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 450-511 2.8e-06 21.6 In-house 2-61 (69) alignment 
Range on Protein: 450-511
Range on HMM: 2-61/69.0
VIHCSAGVGRSGTLMAVEIALQSIHSHfTLPDIKQIVSHLRVtGRAASVQTLQQYMLIWKVL
|.|||.| ||.||..|. . .  | |   | ||   | ..|   |   |   ..|..|   |
vvhcssgtgrtgtfiaimvemarikse.klvdifnnvqymrk.crpmmvmneieyifihdal
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 287-382 6.7e-06 17.9 In-house 48-139 (327) alignment 
Range on Protein: 287-382
Range on HMM: 48-139/327.0
KNRYLNIPCLDISRVQLkvmpnKNSTDYIHANYIRSPflKRGYILTQGPKKETRADFWRMIWQENTTAIVMLC---QFTETNREKCAEYFPRNAHCCLQ
 |  | ||  |  ||           ...  .|.|       ||. | | |..    ||.| ..    .| ||   |.. ..  ||  ||| .    ..
vnvrlpipirdnrrvlc.....gsdeeffpgqyvrme..gaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleqkme