Gene ZK757.2 in Caenorhabditis elegans

Synonym: CELE_C04F12.8, C04F12.8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP14
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP240_AA protein Get Run
CeleP240_AA_11-152 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP14_pd Subfamily DSP14 9-159 7.5e-53 172.7 In-house 2-154 (157) alignment 
Range on Protein: 9-159
Range on HMM: 2-154/157.0
REQRQCSQIRPYLYVSGLAALSPRVLSRFCV--CINLIPGFRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFG
.|....|||.|.|..|| ||||...|.. ..  .||...       .....|..|..||....|..|. .|...|||..| .|..|. |..|.||||.. 
pelaalsqitpsLflsgvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslc

IAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKLRGKVSCKIIE
.||.|.|||..|...||.|. ||.||.|||||..||||.|.||.||.| |...
laylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmvd
PTPc_motif_SM00404 14-148 3.1e-33 109.6 In-house 2-140 (140) alignment 
Range on Protein: 14-148
Range on HMM: 2-140/140.0
CSQIRPYLYVSGLAALS-PRVLS--RFCVCINLIPGFRL-SAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAY
.|.| |.||.... . . |..|.  .....||..   .| .. ........||.|||...||... .|.. ||.|.|  |. |  |..|.|||||. |||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

VMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQK
.|.|.. .|...|..|.  |.||.||..|..|||..|.|
lmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
subfamily_DSP10_pd Subfamily DSP10 9-152 7.8e-29 94.6 In-house 9-156 (159) alignment 
Range on Protein: 9-152
Range on HMM: 9-156/159.0
REQRQCSQIRPYLYV-SGLAALSPRVLSRFCV--CINLIPGFRLSAP-PHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSAT
.|. . ||. |.|.. |.  | .  .| |. .   .|. .         ..|  ..|..|... .|. .. . .. ||||||   | |. |  |||||||
ietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsat

FGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKLRGK
. |||.|.. . .|.|.|| |. .| || ||..|  ||...|..|. .
vviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnks
0044763 (Phosphotyrosine protein) phosphatases II 7-151 3.9e-26 87.2 In-house 16-172 (178) alignment 
Range on Protein: 7-151
Range on HMM: 16-172/178.0
INREQRQCSQIRPYLYVSGLAAlsPRVLS-----RFCVCINLIPGFRLSAPPH---------MKVVHLPLQDNETTDLSPHWANVYKEIEEAR-KGAGRA
   ..  .|.| |.||...| .  .. |       . . .|| . ..|  ...         ....|.|. |. ..||. |. .... ||||. .  |. 
ersdyinaseilpglylgslpp..addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpv

LLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNiICPNVGFFQQLIDLEQKLRG
|  | .|..||.|. .|| | . . .|.. .. |. .|. |.|| |. .||...|..|..
lVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP1_pd Subfamily DSP1 17-150 1.1e-24 81.4 In-house 21-157 (163) alignment 
Range on Protein: 17-150
Range on HMM: 21-157/163.0
IRPYLYVSGL-AALSPRVLSRF--CVCINLIPGFRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQY
| ..||. .   |   ..|..      .|.        . ...  .|.|.|... |.| .. .| . |.|..|  |. |. |..|||||.|. .||.|. 
ildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmkt

EKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKLR
.. .|.. .. |.  |.|| ||.|| .||.. |.|| 
krvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP6_pd Subfamily DSP6 51-150 2.3e-23 76.5 In-house 56-155 (158) alignment 
Range on Protein: 51-150
Range on HMM: 56-155/158.0
APPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKLR
  ...| ...|..|. ...|. .. .  . |.|||.     |. |  ||||| |  .||.|.... .| |.|. |.  .  | ||  |..||.| |..||
esgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslr
subfamily_DSP19_pd Subfamily DSP19 12-149 7.8e-23 75.5 In-house 10-150 (152) alignment 
Range on Protein: 12-149
Range on HMM: 10-150/152.0
RQCSQIRPYLYVSGL-AALSPRVLSRFCV--CINLIPGFRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIA
 . ....|.||..   .| . . |..  .   .|.  |     | ......... |.. |||. .. .. . |||||.  |. |. |  |.||||.. ||
levgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvvia

YVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKL
|.|. |...|..... |. ||  |.|| ||..|| ..|..|
ylmkkeelsleealelvrearpcikPneGFikqLkeyeael
DSPc Dual specificity phosphatase, catalytic domain 36-148 1.3e-22 75.1 Pfam-A 18-133 (133) alignment 
Range on Protein: 36-148
Range on HMM: 18-133/133.0
RFCVCINLIPGFRL---SAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNII
 . . ||..   .    ..... . ...|..|...|..|..  .... ||.|..  .. |  |..|||||||. ||| |.... .| . |..|.  |..|
gitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrski

CPNVGFFQQLIDLEQK
.||.|| .||...|.|
spnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 36-148 1.3e-22 75.1 In-house 18-133 (133) alignment 
Range on Protein: 36-148
Range on HMM: 18-133/133.0
RFCVCINLIPGFRL---SAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNII
 . . ||..   .    ..... . ...|..|...|..|..  .... ||.|..  .. |  |..|||||||. ||| |.... .| . |..|.  |..|
gitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrski

CPNVGFFQQLIDLEQK
.||.|| .||...|.|
spnagflrqLleyerk
subfamily_Slingshot_pd Subfamily Slingshot 54-147 2.6e-22 73.0 In-house 62-155 (169) alignment 
Range on Protein: 54-147
Range on HMM: 62-155/169.0
HMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ
... ... . |.|.||| ..| . || ||.|.|   ..|. | ||.||||.  ||| |.  . .|..... |.  |..| || ||..||   | 
kfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeG
0048076 (Phosphotyrosine protein) phosphatases II 14-149 2.9e-22 74.3 In-house 4-142 (145) alignment 
Range on Protein: 14-149
Range on HMM: 4-142/145.0
CSQIRPYLYVSGLAALS-PRVLSRF--CVCINLIPGFRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYV
 |.| |.||...| . .  . | ..     .|| . ..|  . ......||. |... ||. .. .... ||||.|  |. |  | .|..|..|. .||.
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKL
| ... .|.. .. |. .| ...||.|....|...|..|
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP3_pd Subfamily DSP3 56-151 5.1e-22 72.2 In-house 64-159 (162) alignment 
Range on Protein: 56-151
Range on HMM: 64-159/162.0
KVVHLPLQDNETTDLSPHWANVYKEIEEARKG-AGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIiCPNVGFFQQLIDLEQKLRG
| . |...|. ..||| .. .. | |.|| .   |. |. |..|.|||||  .||.| ..| ||..  ..|.  |.| .|| ||..||..|...|. 
kylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldeelkr
0049772 (Phosphotyrosine protein) phosphatases II 52-150 7.6e-22 73.9 In-house 178-274 (314) alignment 
Range on Protein: 52-150
Range on HMM: 178-274/314.0
PPHMKVVHLPLQDnETTDLSPHWANVYKEIEEArKGAGRALLLCAMGISRSATF-GIAYVMQYEKKTLHDSYKAVQLARNiICPNVGFFQQLIDLEQKLR
 ...|....|. | ....|. ..  ... |||| .  |. |  |..|..|..||  .||.| . . .|.. .. |.|.|  |.|| ||..||...|..|.
rlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefile
subfamily_DSP8_pd Subfamily DSP8 53-150 1.8e-21 70.3 In-house 58-155 (159) alignment 
Range on Protein: 53-150
Range on HMM: 58-155/159.0
PHMKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKLR
.. |....|..|. . .|.| . . .. |. |..  || |. .  |||||||  |||.|.. . .| ..|. |.  |. | ||. | .||.. |..|.
keskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
0048179 (Phosphotyrosine protein) phosphatases II 15-149 4.4e-21 70.5 In-house 5-144 (144) alignment 
Range on Protein: 15-149
Range on HMM: 5-144/144.0
SQIRPYLYVSGLAALSPRVLS-R--FCVCINLIPGFRLSAPPHM--KVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAY
|.| |.||...| ...   |  .  .   |||....    . ..  ...|||. |... ||. .. .... ||||..  |. |  | .|..|..|. .||
seilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay

VMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKL
.| ... .|.. .. |. .| ...|| |....|...|..|
lmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 57-148 8.9e-21 67.9 In-house 55-146 (148) alignment 
Range on Protein: 57-148
Range on HMM: 55-146/148.0
VVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQK
 .|..|.|..  |||  . .. . ...|..  .| |. . ||.|||.  ............|.. . .|. .|. . || || .|| .|||.
YlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqa
subfamily_DSP12_pd Subfamily DSP12 45-143 1e-19 65.5 In-house 40-137 (155) alignment 
Range on Protein: 45-143
Range on HMM: 40-137/155.0
PGFRLSAPPHMkVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLI
| ..|..       .... |....|.  |  .. . ||||..  |  |  |..|.|||.|. |||.|..||  |.. .|.|. ... |.|| || .|| 
pehklkkgkvs.tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLk
subfamily_MKPLT_pd Subfamily MKPLT 59-153 8.6e-19 61.6 In-house 70-164 (164) alignment 
Range on Protein: 59-153
Range on HMM: 70-164/164.0
HLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKLRGKV
 . ..|. .. ||..   . | . .| .. || |. | .| |||..  .|....... ||...|. ..  | |. || ||..||   |. . |||
qvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGkv
subfamily_MKPLV_pd Subfamily MKPLV 59-153 8.6e-19 61.6 In-house 70-164 (164) alignment 
Range on Protein: 59-153
Range on HMM: 70-164/164.0
HLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKLRGKV
 . ..|. .. ||..   . | . .| .. || |. | .| |||..  .|....... ||...|. ..  | |. || ||..||   |. . |||
qvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGkv
0041856 (Phosphotyrosine protein) phosphatases II 52-152 2.9e-18 61.6 In-house 77-175 (182) alignment 
Range on Protein: 52-152
Range on HMM: 77-175/182.0
PPHMKVVHLPLQDNETTDlsphWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARN--IICPNVGFFQQLIDLEQKL
   .....||  |....|    .  ... |||...  |. |  | .|..|..|. .||.| . . .| . .| |. .|.  .|.|| .|| ||. || .|
rlgiqylylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll

RGK
..|
lkk
subfamily_STYXL1_pd Subfamily STYXL1 55-152 2.9e-18 59.6 In-house 59-156 (157) alignment 
Range on Protein: 55-152
Range on HMM: 59-156/157.0
MKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKLRGK
 |..|....|.. .|| ..  .. . ||. .|     |.    ||||||.  |||.| ..| ||...|| ..  .. ..|| .| .|| . |..| |.
akllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllge
0046846 (Phosphotyrosine protein) phosphatases II 49-151 2.6e-17 58.6 In-house 71-174 (176) alignment 
Range on Protein: 49-151
Range on HMM: 71-174/176.0
LSAPPHMKVVHLPLQDNETTDLsPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQY-EKKTLHDSYKAVQLARN-IICPNVGFFQQLIDLE
.   ..... |||  |. . ||  .. .....|.||.|  |. |  | .||.|..|. .|| ...    .... .. |.  |   . .. .. ..| . |
eleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefe

QKLRG
..|..
llllk
0045098 (Phosphotyrosine protein) phosphatases II 48-150 4e-17 58.0 In-house 149-272 (278) alignment 
Range on Protein: 48-150
Range on HMM: 149-272/278.0
RLSAPPHMKVVHL-PLQDNETTDLS--PHWANVYKEIEEARK--------------GAGRALLLCAMGISRSATFGIAYVMQYE---KKTLHDSYKAVQL
    . .....|. |  |... .|.   .. .....|.||.|              . |. |  | .|..|..|. .|| | .    . .| . .| .. 
edlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrs

ARNI-ICPNVGFFQQLIDLEQKLR
 |.. ...| .....|......|.
qRpglavqnleqyrflyefllell
subfamily_LRR-DSP_pd Subfamily LRR-DSP 56-149 4.2e-17 56.1 In-house 165-258 (263) alignment 
Range on Protein: 56-149
Range on HMM: 165-258/263.0
KVVHL-PLQDNETTDLSPHWANVYKEIEEARKGAGrALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKL
| . .  ..| .  |.| |. ..   ||| ||  |  |. |  |.|||.|  |.|.|.... ......  |.  |. | || || .||   |.||
kylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
0043147 (Phosphotyrosine protein) phosphatases II 51-149 1.6e-16 56.0 In-house 62-160 (172) alignment 
Range on Protein: 51-149
Range on HMM: 62-160/172.0
APPHMKVVHLPLQDNETTdLSPHWANVYKEIEE--ARKGAGRALLLCAMGISRSATFGIAYVMQyEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQK
 .  ... .||  |. .. |. .. .... |.|  |..  |. |  | .|..|..|. .|| |. .. .|.. .. |. .|.....| .. ..| ..|..
erlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekl

L
|
l
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 57-151 6.5e-16 51.7 In-house 49-143 (145) alignment 
Range on Protein: 57-151
Range on HMM: 49-143/145.0
VVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKLRG
.. .  .| |. ||| |. .|   |.  ..     .. |  |.||| |  .|..|.| . || .. . |.  |   .||| |...|..||..|. 
illitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlke
0040439 (Phosphotyrosine protein) phosphatases II 42-149 1e-15 53.5 In-house 84-245 (249) alignment 
Range on Protein: 42-149
Range on HMM: 84-245/249.0
NLIPGFRL-------------------------------------------SAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARK------GAGRAL
.| . ..|                                             ... .| |..  |   ....|. . . . ||..||        |. |
mLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvl

LLCAMGISRSATFGIAYVM-----QYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKL
  | .|..|..|| .|| |      . . .| . .| .. .|. ...| .....|......|
VHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_DSP15_pd Subfamily DSP15 58-148 1.2e-15 51.9 In-house 48-138 (151) alignment 
Range on Protein: 58-148
Range on HMM: 48-138/151.0
VHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQK
  ....|   ..|| .  .  . | ..|   .  |. |..|.|||.|  .||.|   .   .|. .... || .  ||.|| .|| . |..
kciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
0049260 (Phosphotyrosine protein) phosphatases II 44-149 1.3e-15 52.8 In-house 44-149 (152) alignment 
Range on Protein: 44-149
Range on HMM: 44-149/152.0
IPGFRLSAPPHMKVVHLPLQDNETTDLSPHWANVYKEIEE-ARKGAGRALLLCAMGISRSATFGIAYVMQyEKKTLHDSYKAVQLARNIICPNVGFFQQL
 .  .|  . .... |||  |. . ||| .   ... ||. |..  |. |  |  |..|..|. .|| |   . .| . .. |. .|....|| |. ..|
lelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrfl

IDLEQKL
 . |..|
yefekll
0045450 (Phosphotyrosine protein) phosphatases II 52-149 2.5e-15 52.5 In-house 175-303 (307) alignment 
Range on Protein: 52-149
Range on HMM: 175-303/307.0
PPHMKVVHLPLQDN-----------------ETTDLSPHWANVYKEIEEARK------GAGRALLLCAMGISRSATFGIAYVMQYEK--------KTLHD
 ....| .|...|.                   ....|... . . |||.||      . |. |  | .|..|..|| .||.| .           .| .
ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlle

SYKAVQLARNIICPNVGFFQQLIDLEQKL
 .| ..  |  ...| .....|......|
avkllreqRpgavqnpeqyrflyeallel
0036282 (Phosphotyrosine protein) phosphatases II 38-152 4e-15 51.4 In-house 52-172 (174) alignment 
Range on Protein: 38-152
Range on HMM: 52-172/174.0
CVCINLIPGF-RLSAPPHMKVVHLPLQDNETTDLSPhWANVYKEIEEARKG--AGRALLLCAMGISRSATFGIAYVMQYEKK-TLHDSYKAVQLAR---N
. |||. | .     . ......||  |... |||  . ...|..|||..    |  |  | .|..|..|. .|| | . .. .| | .. |. .|    
ykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrp

IICPNVGFFQQLIDLEQKLRGK
 .... .....| ..|..|.|.
gmvqtpsQyrflyyfekllsgs
0037934 (Phosphotyrosine protein) phosphatases II 53-149 7.4e-15 50.6 In-house 134-241 (243) alignment 
Range on Protein: 53-149
Range on HMM: 134-241/243.0
PHMKVVHLPLQD----NETTDLSPHWANVYKEIEE-----ARKGAGRALLLCAMGISRSATFGIAYVMQYE-KKTLHDSYKAVQLARNI-ICPNVGFFQQ
 .... .||  |    ....||  ..  |.. |||     |... |. |. | .|..|..|. .||.| .  . .| . .| ..  |.  .... .....
lvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrf

LIDLEQKL
|......|
lyeallel
PTEN_1 53-149 5.3e-14 47.5 In-house 93-191 (196) alignment 
Range on Protein: 53-149
Range on HMM: 93-191/196.0
PHMKVVHLPLQDNETTDLSPHWANVYKEIEEARK--GAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKL
 .... |.| .|  . .|| ... ... || ...    . .|  |. |..||.|  .|| |...| | ..  . |. .|  ..|| .. ..|.  ...|
sgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 56-150 9.7e-14 45.0 In-house 57-153 (154) alignment 
Range on Protein: 56-150
Range on HMM: 57-153/154.0
KVVHLPLQDNETTDLSPHWANVYKEIEEARKG--AGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKLR
. ..| | |.   |.  .   ... |..|  |   .. |. .  |.||||.. |.|.|.  | .|  ... .. .| || || || .||   |..|.
eylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifekell
0042113 (Phosphotyrosine protein) phosphatases II 54-148 1.9e-13 45.9 In-house 140-241 (245) alignment 
Range on Protein: 54-148
Range on HMM: 140-241/245.0
HMKVVHLPLQDNETTDLSPHWANVYKEIEEARK--GAGRALLLCAMGISRSATFGIAYVM-----QYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLE
.. . .||  |. ..||. .  ........|..  . |. |  | .|..|..|| .|| |      . . .| . .| ..  |  .... .....|....
vihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal

QK
..
le
0040438 (Phosphotyrosine protein) phosphatases II 52-150 2e-13 45.8 In-house 153-276 (317) alignment 
Range on Protein: 52-150
Range on HMM: 153-276/317.0
PPHMKVVHLPLQDN----------------ETTDLSPHWANVYKEIEEARKG----AGRALLLCAMGISRSATFGIAYVM-----QYEKKTLHDSYKAVQ
 ..... .|...|.                   .. |..  . . .|..|.      |  |  | .|..|..|| .||.|     .... .. . .| ..
lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelr

LARNIICPNVGFFQQLIDLEQKLR
 .|. .... .....|.|..... 
eqRpgavqtpeqyrflydalleyl
subfamily_MSG5_pd Subfamily MSG5 44-150 2.1e-13 43.7 In-house 58-161 (165) alignment 
Range on Protein: 44-150
Range on HMM: 58-161/165.0
IPGFRLSAPPhMKVVHLplQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLI
|. ..|  |. .|  |.  . . .. .    ... . |  |.    . |. |  |.||||.. .||.|.| . .|.|.|. ..   . | |..|.  ||.
indlellvpa.vkyyhi..ewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlm

DLEQKLR
. |  | 
ewevals
0036941 (Phosphotyrosine protein) phosphatases II 52-149 2.5e-13 45.5 In-house 165-276 (297) alignment 
Range on Protein: 52-149
Range on HMM: 165-276/297.0
PPHMKVVHLPLQDNETTDLSPHWANVYKEIEEARK------GAGRALLLCAMGISRSATFGIAYVM--------QYEKKTLHDSYKAVQLARNIICPNVG
... .| |.   .    .. ...| . . ||..||      . |. |  | .|..||.|| .|..|         ... .. . .| .   |. ......
gesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle

FFQQLIDLEQKL
....|......|
qyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 54-150 6.1e-13 44.3 In-house 168-289 (297) alignment 
Range on Protein: 54-150
Range on HMM: 168-289/297.0
HMKVV-----------------HLPLQDNETTDLSPHWANVYKEIEEARK---GAGRALLLCAMGISRSATFGIAYVM-----QYEKKTLHDSYKAVQLA
...|                  ...  |. . ... .  .......||..   . |. |  | .|..|..|| .|| |      . . .. . .| .. .
gytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreq

RNIICPNVGFFQQLIDLEQKLR
|. .... .....|.|....|.
Rpgavqtpsqyrflydallell
subfamily_STYX_pd Subfamily STYX 55-147 4.2e-12 39.5 In-house 63-155 (166) alignment 
Range on Protein: 55-147
Range on HMM: 63-155/166.0
MKVVHLPLQDNETTDLSPHWANVYKEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ
.. . | . || . ..  .  .| . |... .  |. |.    ||||||.. |||.|.       .... ||  |  | || || .|| . | 
frylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0051082 (Phosphotyrosine protein) phosphatases II 16-145 4.8e-12 41.2 In-house 10-149 (151) alignment 
Range on Protein: 16-145
Range on HMM: 10-149/151.0
QIRPYLYVSGLAalSPRVLSR-----FCVCINLIPGF------------RlsapphMKVVHLPLQDNETTDLSPHWANVYKEIEEARKG-AGRALLLCAM
.. ..||.||    ....|       . . .|| . .                   ..|.|.|. |. ...|. ... | . .|....   |  |  | .
yvtgglyrsggp..ladflellkelgiktivnlrseeergycpeylpelg......ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsa

GISRSATFGIAYVMQyEKKTLHDSYKAVQLARN-IICPNVGFFQQLIDL
|..|..|. ..| |  .. .| . .. ..| |  ...|| .|. ||..|
GkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
0051429 (Phosphotyrosine protein) phosphatases II 52-149 3.2e-09 32.4 In-house 67-224 (272) alignment 
Range on Protein: 52-149
Range on HMM: 67-224/272.0
PPHMKVVHLPLQDNETTDLS---------------------------------------------------PHWANVYKEIEEarkgAGRALLLCAMGIS
.|.....|||. |..... .                                                       .. ... .     |. |  |. |..
wpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkd

RSATFGIAYVMQyEKKT--------------LHDSYKAVQLARNIICPNVGFFQQLIDLEQKL
|..|.  .. .  .  .              | . .. .. .|  . .. .....| . ...|
RTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 56-147 9.8e-09 30.5 In-house 177-274 (278) alignment 
Range on Protein: 56-147
Range on HMM: 177-274/278.0
KVVHLPLQDNETTDLSPHWANVYKEIEEARK-GAGRALLLCAMGISRSATFGIAYVM-----QYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQ
 . .|.  |... .   .  . .|.. ||..   |  |  |  |..|..|| ..|..      . . .|.. .| ..  |  ....  ....|.....
hyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0038934 (Phosphotyrosine protein) phosphatases II 56-151 1.3e-08 30.3 In-house 81-178 (194) alignment 
Range on Protein: 56-151
Range on HMM: 81-178/194.0
KVVHLPLQDN---ETTDLSPHWANVYKEIEEARKGaGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPNVGFFQQLIDLEQKLRG
....||  |     ....  .. .. .|. .. .| |  .  | .|..|..|. .|| ... . ....... .. .|. . ||......|    . || 
eylklpfpddgtvPsleillrfldlvdeflnedpg.gvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrk
0047943 (Phosphotyrosine protein) phosphatases II 60-144 1.5e-07 26.6 In-house 174-266 (273) alignment 
Range on Protein: 60-144
Range on HMM: 174-266/273.0
LPLQDNETTDLSPHWANVYKEIEEARK---GAGRALLLCAMGISRSATFGIAYVM-----QYEKKTLHDSYKAVQLARNIICPNVGFFQQLID
..  |. . .   .  . ......|..   . |  .  |  |..|..|| .....      . . .. . .| ..  |  . ... ....|..
tgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
subfamily_PTPMT1_pd Subfamily PTPMT1 72-135 2.2e-06 22.3 In-house 88-154 (171) alignment 
Range on Protein: 72-135
Range on HMM: 88-154/171.0
PHWANVY---KEIEEARKGAGRALLLCAMGISRSATFGIAYVMQYEKKTLHDSYKAVQLARNIICPN
|.....    . ||. ..   |  . |  | .||||  ..|.|. || ....  ||..  |.||  .
pdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirla