Gene ZK783.5 in Caenorhabditis elegans

Synonym: CELE_ZK783.5, ZK783.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf5
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP241_AA protein Get Run
CeleP241_AA_3-186 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1-222 3.4e-166 546.0 In-house 125-346 (346) alignment
Range on Protein: 1-222
Range on HMM: 125-346/346.0
MENESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKT
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
menesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppkt

LPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKRGGKKAPVNKDI
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||
lpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggkkapvnkdi

KRFINELTEISPACSPTKVMPL
.|||.||.||||||||||||||
nrfidelaeispacsptkvmpl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 4-188 7.1e-54 177.3 In-house 103-288 (302) alignment
Range on Protein: 4-188
Range on HMM: 103-288/302.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPK-EYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLP
|. ||.|| |..||.|  |...| ...||.|   ||  . | |.. ||||.|||. . . . | .|.||||||| |.||...| ..  ||. . | |   
edsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyae

IIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
.|| ...   .|.  .. . .||  |.||| .|. .  |...|..| |||| ||.|.|..|||  |.|. ||.|.| ..  || .|
liktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk

Y_phosphatase Protein-tyrosine phosphatase 4-182 9.6e-43 141.6 Pfam-A 52-234 (235) alignment
Range on Protein: 4-182
Range on HMM: 52-234/235.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFND-ENGGYQYTGKMFINNRrADVSGDPKEYTIEVLPEGNSDSV----ICQVHHHAPWKHLQQPP
.|..|||| |..||......... ... ...... . . |.......|....... .... | ||||...|   ....     . ...|.  |.. . | 
kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpe

KTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVF
.. .....|... ..|. ... |.|..  |.||...|. . ....||... |.....|.|....|||| |.|..||. .|....
spkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 4-182 9.6e-43 141.6 In-house 52-234 (235) alignment
Range on Protein: 4-182
Range on HMM: 52-234/235.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFND-ENGGYQYTGKMFINNRrADVSGDPKEYTIEVLPEGNSDSV----ICQVHHHAPWKHLQQPP
.|..|||| |..||......... ... ...... . . |.......|....... .... | ||||...|   ....     . ...|.  |.. . | 
kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpe

KTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVF
.. .....|... ..|. ... |.|..  |.||...|. . ....||... |.....|.|....|||| |.|..||. .|....
spkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0040438 (Phosphotyrosine protein) phosphatases II 4-221 1.3e-39 131.7 In-house 96-310 (317) alignment
Range on Protein: 4-221
Range on HMM: 96-310/317.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPI
.. ||||| |.........  ... . |.. .   .  . |.... |.......  .. .. . .|.|| . |.|.|......|.  | .   || . ..
pntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdll

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIsrKRGGKKAPVNKDIKRF
......  .  . ..  |.| .  |.||...||.|.....||. . .... |..| ...||||.|....||  .| ....|.  ||.... |... ....
ldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl..krkltlepaselklkl

INELTEISPACSPTKVMP
...|... .  .. |...
lklliplalddvklkeke

0036941 (Phosphotyrosine protein) phosphatases II 4-190 5.8e-39 129.6 In-house 88-282 (297) alignment
Range on Protein: 4-190
Range on HMM: 88-282/297.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADV--SGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKT
.. ||||| |....... .  ..... | ...  . . .|.|.... |........ .|  ..| . .|.||.. ||..| .....|.  | .   |. .
pntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpesp

LPIIKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLN---NGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKRG
 .....|.....  .   ..  |.| .  |.||...||.| ....||.      ...|.|..| ...|||| |... ||  .| ...... .|. 
aslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

DSPc_SM00195 4-185 1.7e-38 127.8 In-house 79-262 (263) alignment
Range on Protein: 4-185
Range on HMM: 79-262/263.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADVSG-DPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTL
.| ||||| |...|...... .. ...  |.. .. ...|.||..  ||. ..... .    . . .|.|.  ||....  ......  |.. . | .| 
pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstk

PIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
......... ..|. ... ..|..  |.||...|. . .....|... ...|.||.|....|||| |....||. || .. .||
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 4-185 1.7e-38 127.8 In-house 79-262 (263) alignment
Range on Protein: 4-185
Range on HMM: 79-262/263.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGGYQYTGKMFINNRRADVSG-DPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTL
.| ||||| |...|...... .. ...  |.. .. ...|.||..  ||. ..... .    . . .|.|.  ||....  ......  |.. . | .| 
pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstk

PIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
......... ..|. ... ..|..  |.||...|. . .....|... ...|.||.|....|||| |....||. || .. .||
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0050432 (Phosphotyrosine protein) phosphatases II 5-188 1.6e-37 124.9 In-house 119-302 (308) alignment
Range on Protein: 5-188
Range on HMM: 119-302/308.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLK-NTTTSLFNDENG-GYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLP
. ||||| |.........  .   .  . ..    . .| | |... ||....... .| .| . .|.|. . |...| .... |.  |.. . ||.. .
ntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspei

IIKMIHQFLSEKqvQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
.......  .    ..  ..| .  |.||.. || ......||. . .....|..| ...|||| |... ||  .| ....|...|
lldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

0046845 (Phosphotyrosine protein) phosphatases II 5-189 3.1e-36 120.6 In-house 88-278 (284) alignment
Range on Protein: 5-189
Range on HMM: 88-278/284.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQPPKTLPI
. ||||| |.........  . . .  ...  . .  ..|.... |........ .| .| . .|.|. ..| .. |......|. .| . . || . ..
ntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedl

IKMIHQFLSEKQ--VQNAGVCVVSLFGCGRACSFIGALYAINQLNNGI---EPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKR
......  .  .   ..  ..| .  |.||.. || . ....||...    .....|..| ...|||| |....||  .| ....|...|.
leflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

0043336 (Phosphotyrosine protein) phosphatases II 4-185 1.4e-35 118.5 In-house 98-277 (278) alignment
Range on Protein: 4-185
Range on HMM: 98-277/278.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDenGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPI
.. ||||| |....... .  ..... |....   .    ||... |........ .. .| . .|.|| . |.. | .....|. .| . . |. . ..
petvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsll

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
.........  . .|  |.| .  |.||.. ||.......||... .....|..| ...|||| |... ||  .| ....|.
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

0051299 (Phosphotyrosine protein) phosphatases II 5-185 2.7e-35 117.6 In-house 103-286 (288) alignment
Range on Protein: 5-185
Range on HMM: 103-286/288.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE----GNSDSVICQVHHHAPWKHLQQPPKT
. ||||| |.........  . . . |....   .  . ||... |........ .| .| . .|.|| .     |.. | .....|.  | . . |. .
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

LPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
 ......... .  . ..  |.| .  |.||.. || ......||... .....|..| ...|||| |... ||  .| ....|.
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0047943 (Phosphotyrosine protein) phosphatases II 6-185 4.1e-35 117.0 In-house 89-272 (273) alignment
Range on Protein: 6-185
Range on HMM: 89-272/273.0
FVEDFWYMIYQEQIHLVYLMVPDDKL-KNTTTSLFNDENGG-YQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPI
 ||||| |.........  ..... | ...    . .|.|. ... ||....... .. .| . .|.|. . |...| .....|. .|   . || . ..
tvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesl

IKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
...|..  .  .   .|  |.| .  |.||...|| ......||. . .....|..| ...||||.|... ||  .| ....|.
lefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0039614 (Phosphotyrosine protein) phosphatases II 4-189 1.3e-34 115.4 In-house 111-293 (297) alignment
Range on Protein: 4-189
Range on HMM: 111-293/297.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGgyqYTGKMFINNRRADVSGDPKEYTIEVLPegNSDSVICQVHHHAPWKHLQQPPKTLPI
.. ||||| |....... .  . . . |...  . . .| |   . |........ .. .. . .|.|| .  |. | ....... .| . . || .  .
petvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslell

IKMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKR
......  .  .   ..  |.| .  |.||...||.|.....||. . .... |..| ...||||.|... ||  .| .......||.
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

0045450 (Phosphotyrosine protein) phosphatases II 5-187 1e-32 109.5 In-house 118-306 (307) alignment
Range on Protein: 5-187
Range on HMM: 118-306/307.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE-GNSDSVICQVHHHAPWKHLQQPPKTLPI
. ||||| |.........  . ... |..     .  ..|.... |........ .. .. . .|.|| .  |.. | .....|.  | . . || . ..
etvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

IKMIHQFLS--EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIE---PNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
...|.. ..  |.  ..  |.| .  |.||...||.|.... ||... .   ... |..| ...||||.|... ||  .| ...... .
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk

0040439 (Phosphotyrosine protein) phosphatases II 5-186 2.5e-32 107.8 In-house 65-247 (249) alignment
Range on Protein: 5-186
Range on HMM: 65-247/249.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPII
. ||||| |.....|. .  . ... |.. .   . .. ||... |........ .|..| . .|.|. . ....|. ... .. .| . . || . ...
etvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedll

KMIHQFLSEKQV--QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
..|.. ..  .   ..  |.| .  |.||.. ||.|.....||.   . .. |..| ...||||.|... ||  .| ...... 
dfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

0042113 (Phosphotyrosine protein) phosphatases II 5-186 4.2e-32 106.9 In-house 63-244 (245) alignment
Range on Protein: 5-186
Range on HMM: 63-244/245.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP---KTL
. ||||| |.....|. .  . ... |.  .   .  . |.....|........ .. .| . .|.|| ..|.. |  ....|. || . . |.     |
etvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllelll

PIIKMIHQFLSEkqVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
 ........|.|   .|  |.| .  |.||.. ||.|.....||.   . .. |..| ...|||| |... ||  .| .......
dflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk

0037934 (Phosphotyrosine protein) phosphatases II 5-184 3.5e-21 71.3 In-house 55-241 (243) alignment
Range on Protein: 5-184
Range on HMM: 55-241/243.0
SFVED----FWYMIYQEQIHLVYLMVPDD-KLKNTTTSLFNdenGGYqYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQPP
. |||    || |.....|. .  . ... . ..    ...   |.. . |......    . .| . .|... . . .  .   . .|. || . . |.
etveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPd

KT---LPIIKMIHQFLSE-----KQVQNAGVCVVSLFGCGRACSFIGALYAINQLnngiEPNICEIMKNIKQQRPG-GVESFAQYASIYAIVFDY
 .   | .......|..|     .  ..  |.|    |.||.  .| |.. . .|    . .. |..| ...|||| .|... ||  .| ..  .
spedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel

PTPc_DSPc_SM00012 84-181 5.3e-20 67.0 In-house 3-103 (105) alignment
Range on Protein: 84-181
Range on HMM: 3-103/105.0
QVHHHAPWKHLQQPPKTLPIIKMIHQFLSEKQVQ--NAGVCVVSLFGCGRACSFIGALYAINQLNNG-IEPNICEIMKNIKQQRPGGVESFAQYASIYAI
.. |.  |.. . | .. .|....... ..|. .  .. |.|..  |.||.. |. . ....||...  |..|..|.| ...|||| |....||  .|..
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

V
.
l

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 7-185 2.9e-18 61.2 In-house 112-290 (298) alignment
Range on Protein: 7-185
Range on HMM: 112-290/298.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKM
||||| |. .|.|  . .. .   |..|. . .  ..|  .| |.. .. .. .. .|    ...|  . ....   .  |.  |   . | ..  ....
vedFWrmvteedigtiVmltnleeldktkyhkywPdegkety.geitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldl

IHQFL-SEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
...   |..|  |. | |    | ||. .||     ......     . ...| ....||| |.. .||. || .| ...
lrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal

0045098 (Phosphotyrosine protein) phosphatases II 5-188 3.9e-18 61.3 In-house 75-275 (278) alignment
Range on Protein: 5-188
Range on HMM: 75-275/278.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEnGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE----GNSDSVICQVHHHAPWKHLQQPPKT
| |.||| |.....|. .  . .   |..     .  | ||... |......   .| .|    |..|        .  |   ...|  ||     |. .
stvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslp

--LPIIKMIHQFLSEKQV-------------QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEpnICEIMKNIKQQRPG-GVESFAQYASIYAIVFDY
   ...... . ..  ..             ..  | |    |.||.. ...| . . .|..|.   . |. | ...||||  |... ||  .|  . ..
ilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvd..lleavkelrsqRpglavqnleqyrflyefllel

ISRK
..|.
llrg

subfamily_Ptp69D_pd Subfamily Ptp69D 4-187 1.8e-17 58.4 In-house 101-288 (307) alignment
Range on Protein: 4-187
Range on HMM: 101-288/307.0
ESFVEDFWYMIYQEQIHLVyLMVPDDKLKNT--TTSLFNDEnGGYQYTgKMFINNRRADVSGDPKEYTIEVLPEG------NSDSVICQvHHHAPWKHLQ
|. ..||| || . ...|.  |. . . ||       . .|    ||  .. ..  . .  .|  . ...|   .      .    . | .|.  ||  .
eatigDfWRmiaeqevtli.vmlsnlteknrkkcakYWpie.devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvq.yhytgWkDsk

QPPKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
 |  .  ..|.|.|  . .. ... . |    | ||.  |.     ..||..  . .|.|..|....||.  |.|..||  .|  . ||.| 
vPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 7-186 4.3e-17 57.2 In-house 65-243 (250) alignment
Range on Protein: 7-186
Range on HMM: 65-243/250.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNdENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKM
.|||| |...|..  . ..      ..| .  .   ..  .| |.. ..    .. .| .  .. .  . ..|..| .  |.  |     | ..  ....
iedfWrmvleeksgtivmLtnLkesektyhqywP.vekaeky.GdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLel

IHQFLSEKQV-QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
...  ...|  .|| | |    | ||. .||     ...|..    .. ...| ....||. ||| .|| ..| |.  .. 
lkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald

subfamily_PTPN12_pd Subfamily PTPN12 7-188 6.7e-17 56.3 In-house 96-280 (290) alignment
Range on Protein: 7-188
Range on HMM: 96-280/290.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQY-TGKMFINNRRADVSGDPkeYTIEVLPE--GNSDSVICQVHHHApWKHLQQPPKTLPI
..||| ||.. ....| ..     |. .    .  |.|. .  .|.. ... . .   |   ..|  |     .   .. | |..| |   . | .. ..
lddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavddd..flirtLkveaqkesrkvyqfhYta.WPDhgvPssaksl

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEP---NICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
...|... . .. ..| ..|    |.||.   |   |. ..|.... |   .. ... ....||.  | .  ||  .|  | ......
lelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 7-187 4.9e-16 53.6 In-house 86-270 (274) alignment
Range on Protein: 7-187
Range on HMM: 86-270/274.0
VEDFWYMIYQEQIHLVyLMVPDDKLKNT-TTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDS-VICQVHHHAPWKHLQQPPKTLPII
|.||| |||||..... .|. . | .|    . .  .. .|. ...    . . .   . ..|... |   .. .   .. . .. |   ..| .. ...
vadfWrmiyqeevqvi.vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantll

KMIHQFLS---EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
.....  .   |.. . | | |    | ||.  ||... |..||.. |  .. .|. |....| | |..  ||  |. ..  | .|
dlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr

subfamily_CG7180_pd Subfamily CG7180 4-185 9.7e-16 52.2 In-house 95-290 (296) alignment
Range on Protein: 4-185
Range on HMM: 95-290/296.0
ESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSlFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPE----------GNSDSVICQVHHHAPWKH
.. |..|| ..|.|.|. |  .      ..   | .  ...  || |..|..  . .   . | .|. .  .           . .  |... .   |. 
ketvdefWrlvydeeisavvvLtktfdfakmyps.ywpnkskeqy.geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWel

LQQPPKT----LPIIKMIHQFLSEK--QVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
 .. |      . ........  .   . ... |.|||  | .|.  ....  .......  | .. | .| ....||. ||.  .|  || .. ...
edkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav

subfamily_PTPRA_pd Subfamily PTPRA 5-185 8.2e-15 49.5 In-house 112-295 (330) alignment
Range on Protein: 5-185
Range on HMM: 112-295/330.0
SFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTG-KMFINNRRADVSGDPKEYTIEVLPEGN---SDSVICQVHHHApWKHLQQPPKT
  ||||| ||.. . . . ..   .. |..    .  ..| . |   .. ...    |.   ... .. ||..    .  .. |.| .. | ..  | ..
etvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhfts.wPdvGvPfep

LPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
  ..|....  . .|..   . |    | ||. .||     .....     .. |..|....|||  | .  ||  || .. .| 
iGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_PTPRD_pd Subfamily PTPRD 7-212 1.2e-14 48.9 In-house 104-305 (564) alignment
Range on Protein: 7-212
Range on HMM: 104-305/564.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIKM
.|||| |....... . ..      ...  . .  |.|  .| |.. ..        |    |...  . .|.|   .  |.  | .  .| .. .....
iedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtety.geltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl

IHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRkrGGKKAPVnKDIKRFINE
|..  . .. ..  . |    | ||   ||   . ......    .| ...|....||.  |..  ||. |. .. ....   | .. .. ...|. ...
irkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac..gnteves.enlkqhlqk

LTEISP
|.|...
Laevee

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2-186 1.3e-14 48.7 In-house 95-278 (315) alignment
Range on Protein: 2-186
Range on HMM: 95-278/315.0
ENESFVEDFWYMIYQEQIHLVYlMVPDDKL--KNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIeVLPEGNSDSVICQVHHHApWKHLQQPPK
 ... |.||| |..||..  .  || . .   |      . |...     |.. ..    .  .|     . |. ....   . | . .  | .   . .
Plkasvddfwrmvlqekvttiv.mvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqfte.wPdkGvdkq

TLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
|  ..|.|..  .... ..  . |  . | ||.  .| .   ..|....   .. ...||....||  | .  .|| || .| ... 
tssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 3-186 1.4e-14 48.1 In-house 95-277 (515) alignment
Range on Protein: 3-186
Range on HMM: 95-277/515.0
NESFVEDFWYMIYQEQIHLVYlMVPDDKLKNT--TTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNsDSVICQVHHHaPWKHLQQPPKT
|.. |.||| ...||..  .  || . |  .    .  . |  |     |.. ..    .  ..    ...|| . .    . | | .  | .   |..|
nkasvddfWrlvlqenvttia.mvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhft.eWPdkGvpkht

LPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
  ..|.|..  ....  .  . .  . | ||.  .| .   . . ...   .. ....||.|.||  |    ||| || .| ... 
ssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 5-186 1.4e-14 49.0 In-house 100-284 (305) alignment
Range on Protein: 5-186
Range on HMM: 100-284/305.0
SFVEDFWYMIYQEQIHL-VYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLP-EGNSDSVICQVHHHAPWKHLQQPPKTLP
. |.|||..|..|...  | |    .  |.     . .. .  .  |.. .. .      |  |  ...   .....|     ..   |     | ..  
ntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfats

IIKMIHQFLSEKQVQ-NAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
....|..   ... . .  . |.   | ||.  ||    |...|..  . .. |..|.....|.. |.. .|| ... .. ..| 
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 5-185 3e-14 47.8 In-house 101-279 (288) alignment
Range on Protein: 5-185
Range on HMM: 101-279/288.0
SFVEDFWYMIYQEQIHLVYLMVPD-DKLKNTTTSLFNDENGgYQYTGKMFINNRRADVSGDPKEYTIEVLpEGNSDSVICQVHhHAPWKHLQQPPKTLPI
. |.||| ..|..... .  .    .. |..    . |..   .  |.. .  .     .|  . ....    ...  | | . .  |   . |  . |.
dtvndfWelvyenktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveskeledfvlrkllle.kkkteleitqyq.ylaWpdhgvPeskapl

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
.....|    .| .   . |.   | ||.  || .  .|.....    ...........||.  |.   ||  || .. . |
lellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

0041856 (Phosphotyrosine protein) phosphatases II 7-187 3.2e-14 48.4 In-house 47-173 (182) alignment
Range on Protein: 7-187
Range on HMM: 47-173/182.0
VEDFWYMIYQEQIHLVYLMVpddklkntttslfndengG----YqytgkM-FinnrradvsgdpkeytievlpegnsdSVICQVHHHAPWKHLQQPPkTL
|.||. |.....|...  .                   .    .       .                                ... ||     |. . 
vadflrmlkelgittivnlt..................eelywp.....ell..........................erlgiqylylpwpDhgvpd.ld

PIIKMIHQFLSekqvQNAGVCVVSLFGCGRACSFIGALYAINQlnngiEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
 ....|.. |.    ..  | |    |.||......| . . .     . .. |..| ....|||.|..  ||  .. ...... .
elldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellll

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 3-186 6.5e-14 46.7 In-house 101-285 (297) alignment
Range on Protein: 3-186
Range on HMM: 101-285/297.0
NESFVEDFWYMIYQEQIHLVyLMVPDDKLKNTTTSLFNDENGGYQyTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHH-APWKHLQQPPKT
... |.||| |...||.  . .|. ||. ..     .  ..|  .  |.. .     .      . ..||  .   .  |. | ..   | |  ..  ..
mkatvadfWamvldeqvsti.vmlnddnerdkkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsa

LPIIKMIHQFLSEKQVQNA-GVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
  ..|.|..   . . ..   . |  | | ||.  ..  .  . . ..  | .| ...| ..|.||  |    ||. .| .| ....
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall

subfamily_PTPN23_pd Subfamily PTPN23 6-187 8.6e-14 46.0 In-house 95-282 (288) alignment
Range on Protein: 6-187
Range on HMM: 95-282/288.0
FVEDFWYMIYQEQIHLVY-LMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDS-VICQVhHHAPWKHLQQ---PPKT
 . ||| |.|...  ..  |. .... |. . . .  ..|  .  |.. .  ..   ..   |.....  ....    .. . .   | .|     | . 
tlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshl.qltsWpelGvPasPetl

LPIIKMIHQ-FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLN--NGIePNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
| ... ... . ....  .. . |  . | ||.  |     |...|.  ||. ..| .... ...||   |.  .|.   | .|  .. |
lqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngl.ldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 6-183 9.9e-14 46.5 In-house 80-253 (284) alignment
Range on Protein: 6-183
Range on HMM: 80-253/284.0
FVEDFWYMIYQEQIHLVYLMVpddklkntttslfnDENGGYQYTGKMFINNRRADV----SGDPKEYTIE---VLPEGNS-DSVICQVHHHAPWKHLQQP
 ..||| ||.. ..  . |.               ...    .  |. |.. | .|      . .||..    .  .|.  |    . .|   | .  .|
tladfWrmiweyncstivllt..............kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvp

PKTLPIIKMIHQ--FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
  . ........   |..|. ..| . |    |.||.  .|     ......    .. .......|||.  |....||  ||. . .
dypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 7-186 1e-13 46.0 In-house 99-279 (287) alignment
Range on Protein: 7-186
Range on HMM: 99-279/287.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGyQYTGKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHAPWKHLQQPPKTLPIIK
. .|| .| ..... . ... .   ..     .  |.    . |.  |.    .|. .  | ..||  .. ..|    . .. . |.   . ..   |. 
arnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

MIHQFL-SEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
.|..   ....  |. . |    . ||.  |. |  .||. ..    .. ...|. ..|.|| |   .||  |. ||  |..
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 6-183 1.4e-13 45.9 In-house 116-289 (319) alignment
Range on Protein: 6-183
Range on HMM: 116-289/319.0
FVEDFWYMIYQEQIHLVYLMVpddklkntttslfnDENGGYQYTGKMFINNRRADV----SGDPKEYTIEV---LPEGNS-DSVICQVHHHAPWKHLQQP
 ..||| ||.. ..  . |.                .     .  |. |.. | .|      . .||..       .|.  |    . .|   | .  .|
tladfWrmiweyncstivllt..............kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvp

PKTLPIIKMIHQ--FLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
  . ........   | .|. ..| . |    |.||.  .|     ......    .. .......|||.  |....||  ||. . .
dypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 6-187 3.2e-13 44.4 In-house 103-285 (319) alignment
Range on Protein: 6-187
Range on HMM: 103-285/319.0
FVEDFWYMIYQEQIHLVYLMVP-DDKLKNTTTSLFNDENggYQYTGKMFINNRRADVSGDPKEYTIEVlpEGNSDSV---ICQVHHHAPWKHLQQPPKTL
 .|||| |...|... | ..    .|||     ....||  ..  |.. ..    .   |     ...  . .|. |     . ...  |   . | |..
tiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklkl..nkkssevetRevkhfqyteWpdhdvPekat

PIIKMIHQFLSE-KQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISR
 .......     .. |.  . |    | ||  .||    .......    .. ....... ||.  |.  .||  || .. .... 
slldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 7-186 3.4e-13 44.1 In-house 104-284 (290) alignment
Range on Protein: 7-186
Range on HMM: 104-284/290.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQyTGKMFINNRRADVSGDPKEYTIEVLPEGN--SDSVICQvHHHAPWKHLQQPPKTLPII
. ||| .|.||..  . ...   . ....   .  ...  .  |.. |.     .  .  | ..||  . .  . . . | ..   |..  . ...  |.
lvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtq.yqitnwdstgkvtnpqtil

KMIHQFLS-EKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
 .|..    ...  |  . |    . ||.  |. |  .||. .     .. ...|. ..|.|| |..  ||  |. ||. |..
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 7-218 3.9e-13 44.2 In-house 102-310 (318) alignment
Range on Protein: 7-218
Range on HMM: 102-310/318.0
VEDFWYMIYQEQ-IHLVYLMVPDDKLKNTTTSLFNdENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIK
.|||| |... .   .| |    .. |.     .  ..|  .| ||. .. .    ..|    ...|  .....| . . .|.. |     | ..  ...
ieDfWrmvWeqnsavivmltqeeergkakvhryWP.skgsrsy.gklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslld

MIHQFLSEKQVQNAGVCVV-SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRkrgGKKAPVNKDIKRFI
.. |  . .| ..||. ||    | ||.  ||     ......    .. ...|....||.  |    ||  || .. ...     |..    .|... |
lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas...gdtevdasdlrsri

NELTEISPACSPTK
.||.| .|    |.
relreqdpesgtte

0043147 (Phosphotyrosine protein) phosphatases II 7-178 1.3e-12 43.2 In-house 33-154 (172) alignment
Range on Protein: 7-178
Range on HMM: 33-154/172.0
VEDFWYMIYQEQIHLVYLMVPDdklkntttslfndenggyqytgkmfinnrradvsgdpkeytievLPEGNSDSVICQVHHHAPWKHLQQPpkTLPIIKM
..||| |.....|.... . .                                             |  .   .     ... ||     |  .| ..  
ladfwrmlkelgithivnltel............................................lydpellerlgiqylylpwpDhgvp..llellle

IHQFLSE--KQVQNAGVCVVSLFGCGRACSFIGALYAInqlnNGIepNICEIMKNIKQQRPGGVESFAQYASIY
. .|. |   . ..  |.|    |.||.. .. |.. .     |.  .. |... ....|||.|... ||  .|
flefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl..sleeavalvrekRpgavqnpsqyrfly

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 8-186 2.4e-12 41.1 In-house 97-280 (303) alignment
Range on Protein: 8-186
Range on HMM: 97-280/303.0
EDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDS-VICQVHHHAPWKHLQQPPK-TLPIIK
 ||| || ..... | |.. | . ..        .|  .    . .|           . ... ||   | |   . .|||.  | | . | . .  ..|
adfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvk

MIHQFLSE--KQVQNAGVCVVSLFGCGRACSFigALYAINQLNNGIEPNICEIMKNIKQQRPG---GVESFAQYASIYAIVFDYIS
 | |  |   |  ..     .|| ||||| .|  ||.   .|    | .  ...| ... | |    |. ..|.. .|... ... 
qiwqlqsvlrkysdstptvymslsgcgragtf..alfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl

0046846 (Phosphotyrosine protein) phosphatases II 7-183 2.6e-12 42.3 In-house 36-171 (176) alignment
Range on Protein: 7-183
Range on HMM: 36-171/176.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtgkmfinnrradvsgdpkeytievlpegnsdsvicqVHHHAPWKHLQQPPKtlPIIKM
..||. |.....|..|  .  .  |.      . .|  ....                                     ..| ||   . |.    ..  
ladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................................qylhlpwpDhgvpdl..ellle

IHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINqlnnGIEPNICEIMKNIKQQRP-GGVESFAQYASIYAIVFD
. .|. | . ..  | |    |.||.. .. |.  .     .   .. |... ...||| | |....||  .|  .  
llefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefell

subfamily_PTPN6_pd Subfamily PTPN6 6-189 4.6e-12 40.5 In-house 110-301 (306) alignment
Range on Protein: 6-189
Range on HMM: 110-301/306.0
FVEDFWYMIYQEQIHLVYLMVPD-DKLKNTTTSLFNDENGGYQyTGKMFINNRRADVSGD--PKEYTIEVLPEGNSDSVICQVHHHApWKHLQQPPKTL-
 |.||| |..||. ... ..  . .. |.  .  . ||.   . .||. ..| . .   |   .| ...   ....   . | |... |     | ..  
tvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfks.WPdhgvpkdpga

--PIIKMIHQFLSEKQVQNAG-VCVVSLFGCGRACSFIGAL---YAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKR
    .. ...  .| . ..|| ..|    | ||  .||        |..  . .. .| ...| ...|| | |   .||  .| ..  || .|.
vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk

0049260 (Phosphotyrosine protein) phosphatases II 7-178 8.4e-12 40.5 In-house 22-143 (152) alignment
Range on Protein: 7-178
Range on HMM: 22-143/152.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNdenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqVHHHAPWKHLQQPPKTLPIIKM
..||| |... .|. .  .  .. |.   .                                                 ..| ||     |. .  .. .
ladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDhgvpdlsqlllfl

IHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAInqlnngIEPNICEIMKNIKQQRPGGVESFAQYASIY
..     .. ..  | |    |.||.  .. |.. .         .. |... ....|||.|... |.  .|
llfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 7-185 1.3e-11 39.1 In-house 88-270 (285) alignment
Range on Protein: 7-185
Range on HMM: 88-270/285.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDEN-GGYQYTGKMFIN---NRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPK-TL
. |||.|||||.|  | ...   .      .|.  |. |     ||  |     .   ..|   .    .  |  |   .   | . ||   |  |. . 
lsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedar

PIIKMiHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
|.|.. .... . . ..  .||    | ||...|.|  ||  .. .  . .. .|.....  |   |.|. |.  .| ....|.
pmiel.ykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf

0049772 (Phosphotyrosine protein) phosphatases II 58-189 1.4e-11 40.2 In-house 167-284 (314) alignment
Range on Protein: 58-189
Range on HMM: 167-284/314.0
RadvsgdpkeytiEVLPEGNSDSVICQVHHHAPWKHlQQPPkTLPIIKMIHQFLSEKqVQNAGVCVVSLFGCGRACSFIGALYAINQLnnGIepNICEIM
.            |.| ...  .     ... |.    ..| .| ... . .|. |   ..  | |    |.||...|. | | . .|  |.  .. |..
k............eelydpelferlgikylripvpD.gsap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll..gv..sleeal

KNIKQQRP-----GGVESFAQYASIYAIVFDYISRKR
. ....||     | .|.. ||  |. .. .|.....
edvrlkRpinpnpgfieqleqyefilealleylkflk

subfamily_PTPRK_pd Subfamily PTPRK 5-183 1.6e-11 38.6 In-house 97-275 (314) alignment
Range on Protein: 5-183
Range on HMM: 97-275/314.0
SFVEDFWYMIYQEQIHLVyLMVPD--DKLKNTTTSLFNDENGGYQYTGKMFINNrRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLP
. |.||| ..|.|.   . .|. .  .. .   .  . ..   |.    ....   ..     . ...| |  | ..  . .  ..  | . . | .   
etvkdfWrlvydencasi.vmltelvevgrvkClkyWPedtevygdikvelvet.ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatg

IIKMIHQFLSeKQVQNAGVCVV-SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
..|....  . .| ..||  ||  . |.||.  ||     .. ...    .. ...|.......  ||   ||  || ....
llklvrrvkk.sqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 5-182 2.5e-11 38.1 In-house 103-276 (315) alignment
Range on Protein: 5-182
Range on HMM: 103-276/315.0
SFVEDFWYMIYQEQIH-LVYLMVPDDKLKNTTTSLFNDENGGYqytGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVIcQVhHHAPWKHLQQPPKTLPI
. |.||| ....|.|  .| |    .. |. .   . |..  |   ||. .  .  .|  .    |. |  . |   |. |. |.. |   . |  |.|.
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviy...Gkitvtrkseevnteytvrtlsvvfgdnirevv.ql.hytswpdmgvpkytipl

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVF
...| .    .. . . . |    | ||. .||     ..|..     .. .......|.| . |.. .||  || ...
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall

subfamily_PTPRG_pd Subfamily PTPRG 6-189 6.8e-11 36.1 In-house 103-291 (563) alignment
Range on Protein: 6-189
Range on HMM: 103-291/563.0
FVEDFWYMIYQEQIHLVyLMVPD--DKLKNTTTSLFNDenGGYQYTGKMFINNRRADVSGDPKEYTIEVLP----EGNS--DSVICQVHHHAPWKHLQQP
 ..||| ||.... ...  |...  .. ..     .     . .  |.. ..  . .|   . . |. .      ....  .    . .| . |   . |
tfddFWrmiWeqnvaii.vmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

PKTLPIIKMIHQFlSEKQVQNAG-VCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKR
 ..|| ......  |  . ..|| . |    | ||.  .|     ..|...    |. ...| |. ||.  |..  ||  .. .. . |. | 
ehslpvLifvkks.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

0036282 (Phosphotyrosine protein) phosphatases II 10-178 1.2e-10 36.8 In-house 28-163 (174) alignment
Range on Protein: 10-178
Range on HMM: 28-163/174.0
FWYMIYQEQIHLVYLMVPDDKLKNTTT-----SlfndenggyqytgkmfinnrradvsgdpkeytievlpEGNSDSVICQVHHHAPWKHLQQPP--KTLP
||.|.....|. |  . .   |...       .                                       .. .     ... ||   . |.  . | 
fwemlkelgittvvmlleekelglykcinywpe.....................................lredlerlgiqylylpwpDhgvpdlsille

IIKMIHQFLSEkqVQNAGVCVVSLFGCGRACSFIGALYAINQLNngiePN---ICEIMKNIKQQRPGGVESFAQYASIY
..| ....|||   ..  | |    |.||.  ...|.. . .|     ..   ...... ...||||.|... ||  .|
fvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyrfly

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 3-186 1.9e-10 35.4 In-house 100-290 (325) alignment
Range on Protein: 3-186
Range on HMM: 100-290/325.0
NESFVEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWK--HLQQPPKT
. . ..|.| .... .  .| ..   |. |.  .  . .| |  .  | . .. | ..   |     ..|    . ..   .  ..  |.    |. | |
ltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpat

LPIIKMIHQFLSEKQV----QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI-S
|  |  . . .||.        . . |    | ||.  ||    |.... .  . .| . .|.....||  ||.  ||  ||  . ... |
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms

subfamily_PTPRB_pd Subfamily PTPRB 7-189 1.9e-10 35.3 In-house 107-289 (293) alignment
Range on Protein: 7-189
Range on HMM: 107-289/293.0
VEDFWYMIYQEQIHLVYLMV-PDDKLKNTTTSLFNDENGGYqYTGKMFINNRRADVSGDPKEYTIEVLPeGNSDSVICQvHHHAPWKHLQQPPKTLPIIK
|.||| |..... . . ..    .| |      . ...    . |.. ..    ..  |    ....   ...   . | .|.  |     | || ....
vddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek.ekeerkvrq.yhftsWpdhgvPektktlld

MIHQFLSEK--QVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKR
..... ...  . ... . |    | ||.  ||     ......    .|. |. .....|   | . .||  |.  | |....|.
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkke

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 7-188 2.8e-10 34.8 In-house 97-279 (281) alignment
Range on Protein: 7-188
Range on HMM: 97-279/281.0
VEDFWYMIYQEQIHLVYLM---VPDDKLKntTTSLFNDENGGYQYtGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHApWKHLQQPPKTLPI
...|| |......... ..   .  .|||      . |.|   .| |.. ... ..  .    | ....  |..    . |... | |     | .|  .
lvafWqmvweqkvsaivmvtreieagklk..ChrYWPddnselky.gdvtvkstaeeekatyierkfkleresgetreveqlayta.WPdhGvPattkel

IKMIHQFLSEKQV-QNAGVCVVSLFGCGRACSFIGALYAINQLNNG-IEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
..  .. |. ..  ..| ...    | ||. ..|.   .......   | ............|   | . .||. .| .| |.....
lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke

subfamily_egg_pd Subfamily egg 7-209 1e-09 32.5 In-house 96-293 (307) alignment
Range on Protein: 7-209
Range on HMM: 96-293/307.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQY-TGKMFINNRRADVSGDPKeYTIEVLP-EGNSDSVICQVHHHAPWKHLQQPPKTLPII
|.||| |..||... . ..    . ..      . |.   ..  | . |.| . |   ||  ...  |   |  |      |    .... .    | ..
vddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadpl.frvtklklvGgddeerflehwqgdvnnssdvysplrvl

KMIHQflsekqvQNAGVCVVSLFGCGRACSFIGALYAINQLNNG--IEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIsRKRGGKKAPVNKDIKR
... .           | | .  |. .|.... .  |. .|  |      . . .. ....|.  |||  .|  .| .|  .. |   |    .. | .|
rklrn.......lskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff.rdvigsakeldvdyer

FINELTE
...| .|
wleerse

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 7-182 1.9e-09 31.8 In-house 88-263 (283) alignment
Range on Protein: 7-182
Range on HMM: 88-263/283.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNR--RADVSGDPKEYTIEVLPEGNSDSVICqVHHHAPWKHLQQPPKTLPII
| ||| |...|.|  . .. .    ..   | .  ..|  .| |.. .  |   .  |   || .. |    .|  ...  .    | . .. .    ..
vvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy.Geftvtlrkettsnsfiikelllrvnssakstllla.hyqvidWleygeqaiinslv

KMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVF
|.       .. ... . |    | ||.  ||.|  .....      .. ...|....||.. | .  ||  .. .|.
kfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 3-184 2.2e-09 31.2 In-house 97-235 (392) alignment
Range on Protein: 3-184
Range on HMM: 97-235/392.0
NESFVEDFWYMIYQEQIHLVyLMVPddKLKNTTtslfndenggyqytgkmfinnrradvsgdpkeytievlpEGNSDSVICQVhHHAPWKHLQQPPKTLP
| . ..||| |..||..  .  ||   |||.                                          |...  ..|  | . |   . | .|  
naaslddfwrmvfqenvtti.amvt..klkegd.......................................kgddartvaqf.hftewPdkdvpkhtss

IIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDY
..|.|..  ..       . .    | ||.   |     . . ..    .. ... ||...||  |..  ||| ||. |.. 
llkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled

0048179 (Phosphotyrosine protein) phosphatases II 70-178 3.7e-09 32.0 In-house 34-138 (144) alignment
Range on Protein: 70-178
Range on HMM: 34-138/144.0
IEVLPEGNSDSVICQ--VHHHAPWKHLQQPPKTLPIIKmIHQFLSEK-QvQNAGVCVVSLFGCGRACSFIGALYAInqlNNGiePNICEIMKNIKQQRPG
| . .|   ......   ..| ||   . |. .  ... . .|. |  . ..  | |    |.||..... |   .    .|   .. |... ....|||
inlteeyepefleregiqylhlpwpDhgvpdllellle.flefieeale.eggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpg

GVESFAQYASIY
.|... |.  ..
avpnpgqlrfLl

0051429 (Phosphotyrosine protein) phosphatases II 7-186 4.3e-09 31.9 In-house 35-226 (272) alignment
Range on Protein: 7-186
Range on HMM: 35-226/272.0
VEDFWYMiYQEQIHLVYLMVPDDKLKNTTTS-----------LFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPE-GNSDSVICQVHHHAPWKHL
..|||.. ....|. .  . ... ..   ..            ..|.       |.... .    .  |   .....  . .....    . |.  |   
aadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdh

QQPPKTlpIIKMIHQFLSekqvqNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPN--------ICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
  |...  ........|.     .  | |    |..|   .. .|. . ...     .        . |... ...|||| |.. .||. .| .. ... 
gvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellr





0048076 (Phosphotyrosine protein) phosphatases II 75-181 4.8e-09 31.5 In-house 39-139 (145) alignment
Range on Protein: 75-181
Range on HMM: 39-139/145.0
EGNSDSVICQVHHHAPWKHLQQPPKTlPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINqlnngIEPNICEIMKNIKQQRPGGVESFAQY
| .  .     ... ||   . |. .  ..  . .|. | . ..  | |    |.||......|   .         .. |... ...||||.|... |.
elellerlgiqylylpwpDhgvpdll.ellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgql

ASIYAIV
  .|  .
rflyefe

0044763 (Phosphotyrosine protein) phosphatases II 8-179 5.6e-09 31.4 In-house 38-165 (178) alignment
Range on Protein: 8-179
Range on HMM: 38-165/178.0
EDFWYMIYQEQIHLVYLMVPDDKLK--NTTTSLFNDENggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicQVHHHAPWKHLQQPPkTLPIIK
.|.. ..... |...  . ... |   ..    . ...                                          ..| |.     |.  | .. 
addlellkelgithivnlteelelgflkcdpywpeeag........................................iqylhipipDhgvpd.llehfl

MIHQFLSEKQ-VQNAGVCVVSLFGCGRACSFIGALYAINQlnngiEPNICEIMKNIKQQRPgGVESFAQYASIYA
 ...|. | .  ..  | |    | ||..... | . . .       .. |... ....|| .|... |.  .| 
efvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLye

subfamily_PTPN13_pd Subfamily PTPN13 7-183 6.4e-09 30.5 In-house 90-267 (273) alignment
Range on Protein: 7-183
Range on HMM: 90-267/273.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLF--NDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPII
|.||| |... . ... ..  .   ..     .  . .|   . .... ... .     . .  ...|     ..|   .  . . |   . | ......
vkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaell

KMIHQFLSEKQvQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
... .  . .. ... . |    | ||. ..|    ... ...  | .. ||......|| | | .  ||  .| .. .
qfvaevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 7-188 2.2e-08 28.4 In-house 77-267 (270) alignment
Range on Protein: 7-188
Range on HMM: 77-267/270.0
VEDFWYMIYQEQIHLVyLMVP--DDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDP--KEYTIEVLPEGNSDSVIcqVHHHAPWKHLQQP-----
...|| ||..|. . . .|.    .| ..     .  |..    . ...|. .    . .       ...  .|..  ..   ...  |     |     
lksfwrmiweekvtai.vmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpreeds

-PKTLPIIKMIHQF-LSEKQVQNA-GVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
  .|  ..||...   |||. ..|  . |    | ||.  .|   .|.. |..  . .. .|.......|.  |.   ||. .|. |  |..|.
slstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

subfamily_PTPN3_pd Subfamily PTPN3 7-177 2.4e-08 28.2 In-house 97-267 (280) alignment
Range on Protein: 7-177
Range on HMM: 97-267/280.0
VEDFWYMIYQEQIHLVYLMVP-DDKLKNTTTSLFNDENGGYQYTgKMFINNRRADVSGDPKEYTIEVLPEG-NSDSVICQVHHHApWKHLQQPPKTLPII
..|||.|.......|. ..    .. .      . ...   .|. .. .. .. | .       . .  .  . .  | |. . | |   . | ..  ..
atdfWqmvweqksslivmlttlverGrvkChqyWPetedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqyla.WpdhgvPddsadfl

KMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASI
.....  . .....  | |    | ||.  .|    |.  ...  . .. .|......||   |.. .||  .
efvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfv

subfamily_PTPN14_pd Subfamily PTPN14 6-188 2.9e-08 28.1 In-house 105-299 (300) alignment
Range on Protein: 6-188
Range on HMM: 105-299/300.0
FVEDFWYMIYQEQIHLVYLMVPD-DKLKNTTTSLFNDE--NGGYQYTGKMFINNRRADVS--GDPKEYTIEVLPEGNSDSVICQvhHHAPWKHLQQPPKT
 |.||| |.......|. ..  . .. |. . . | ..  .      ||  . ..  . |     . .... || ..  .|.     .. |   . |.  
tvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhl..qytDWpdhgvPeDv

LPIIKMIHQFLSEKQV---------QNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
 . .. .... | ..          ..  | |  . | ||.   | .   |. |... | .| .... ...||   |...|||  .| ..  |. . 
kgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns

0051082 (Phosphotyrosine protein) phosphatases II 7-179 4.5e-08 28.3 In-house 22-147 (151) alignment
Range on Protein: 7-179
Range on HMM: 22-147/151.0
VEDFWYMIYQEQIHLVYLMVPDDKLKnTTTSLFNDENggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicQVHHHAPWKHLQQPPK---TLPI
 .||. ......|  .. . ...  . . ........                                          ..| |.   . |.    .  .
ladflellkelgiktivnlrseeerg.ycpeylpelg........................................ievlhipildwpdpglplsfdav

IKMIHQFLSekqVQNAGVCVVSLFGCGRACSFIGALYAINQlnngiePNICEIMKNIKQQRPGGVESFAQYASIYA
.......|.    .|  | |    |.||   .....  . .       .. |... ....||| | .. |.  .. 
leflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 6-188 1.2e-07 26.1 In-house 94-274 (288) alignment
Range on Protein: 6-188
Range on HMM: 94-274/288.0
FVEDFWYMIYQEQIHLVY-LMVPDDKLKNTTTSLFNDENGGYQYTGKMF--INNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHaPWKHLQQPPKTLP
 .| .| |. ..... .  |    .| |. .   |  . |     |..   . ..|||.    |  .. .  ||.   .. ..| .  |..   | . |.
tieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhll.eWdddgvPenyls

IIKMIHQFlsekQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
 ..... .    .  .  . | |  | ||.  .|  | |...|       | ..... ...|   ...  ||  .. .|....  |
plrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 36-175 4.8e-07 23.6 In-house 178-330 (347) alignment
Range on Protein: 36-175
Range on HMM: 178-330/347.0
TSLFNDENGGYQYTGKMFINNRRADVSGDPK----EYTIEVLPEGNSDSVICQVHHHAPWKHLQQPP---KTLPIIKMIHQFLSEK----QVQNAGVCVV
.|.|  |   |      .|| |. .|    |     ||.||. || |.. ...|.  . |   . |    | | ...   .  |        . | | |.
ssffpletdhylnlkgwlintravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvm

SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVE--SFAQYA
  .|  |... . .   |.|. .|  |.  ...|....|| |      |  ||
cdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytya

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 6-185 5.7e-07 23.3 In-house 103-279 (439) alignment
Range on Protein: 6-185
Range on HMM: 103-279/439.0
FVEDFWYMIYQEQ-IHLVYLMVPDDKLKntttslFNDENGGyQYTGKMFInnrRADVSGDPKEYTIEV---LP---EGNSDSVICQVHHHApWKHLQQPP
 ..||| ...... ...| |    .  |      .   ..   . | . .   |.|   .  .|.|     .     .. .  . |.|. | | . . | 
ttddfwrlviekktvtivmltnlvesyk......ywpsdae.vcygdiav...rvdrnielpnyvirgfkvfnerdttekertvlqfhyia.wpdknvpa

KTLPIIKMIHQFLSEKQVQNAGVCVVS-LFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
..  ......   | .. .. |  ||    | ||. . |    |..||.   . .|  |.| ...||   |....||  ||  |.. |
qashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 95-185 8.2e-07 23.3 In-house 167-259 (267) alignment
Range on Protein: 95-185
Range on HMM: 167-259/267.0
QQPPKTLPIIKMIHQFLSEKQVQNAGVCVV--SLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYI
.   .  | .| .   |...|..|..  .|     | ||. .|. .   .... .    .| . ...|..||.| |..  .|  |. .. .| 
nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 75-189 9.4e-07 22.8 In-house 179-291 (305) alignment
Range on Protein: 75-189
Range on HMM: 179-291/305.0
EGNSDSVICQ-VHHHAPWKHLQQPPKTLPIIKMihqfLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEP-NICEIMKNIKQQRPGGVESFA
||   ..     .|   |     |.  | |...    | . ..    . |    | ||. | .   | ..|| .|    .   |.. |..||   ... |
egpgekarkvthyhwidwpdrgvpaadlailel....lekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtda

QYASIYAIVFDYISRKR
||  .. ....|. .|.
qylfvhqvilnyfrkkk

subfamily_PTPRN_pd Subfamily PTPRN 7-183 1.5e-06 22.2 In-house 113-290 (297) alignment
Range on Protein: 7-183
Range on HMM: 113-290/297.0
VEDFWYMIYQEQIHLVYLMVPDDKLKNTTTSLFNDENGGYQYtGKMFINNRRADVSGDP---KEYTIEVLPEgNSDSVICQVHhHAPWKHLQQPPKTLPI
| ||| |.... . ..  . . ..   . .. .  ..|   | .   ..     .  |    . . .  |   .    . | | .  |.. . |... ..
vadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevy.hiyevhlvsehiwcddylvrsfylknlqt.setrtvtqfh.flswpeegvPasaksl

IKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGI-EPNICEIMKNIKQQRPGGVESFAQYASIYAIVFD
...  .     . . . . | .  |.||.  .|     .|.|..|. | .|.  .. ...|||| |.. .|.  ... | .
lefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 6-194 1.8e-06 21.8 In-house 108-298 (305) alignment
Range on Protein: 6-194
Range on HMM: 108-298/305.0
FVEDFWYMIYQEQIHLVYLM---VPDDKLKNTTTslFNDENGG-YQYTGKMFINNR-RADVSGDPKEYTIEVLPEGNSDSVICQVHHHaPWKhlQQPPKT
 ...||.|. |...  . ..   |   ||| .    .   .|   .  . . ..|   .       |  | .|    | .    | |   |   . | . 
tidefwwmviqnkveqivmlcktvelgklkcaqy..wpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhl.qwt..ewpdrg

LPIIKMIH-QFLSEKQVQNAGVCVVSLFGCGRACSFIGALYAINQLN-NGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRKRGGKKA
.|  |.   ..||  .  .  . |    | ||. . .   | ....  |   | . |..| ...||   ...  ||  |. ....|.  |   | |
vppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekya

subfamily_PTPN9_pd Subfamily PTPN9 7-188 2.1e-06 22.0 In-house 98-293 (297) alignment
Range on Protein: 7-188
Range on HMM: 98-293/297.0
VEDFWYMIYQEQIHLVYLMV-PDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPIIK
|.||| |......  . ..    .. .   .  ...|..  .  |.. ..|   ... | |. ..|.    ...|     .    |     |  .  ...
vsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslld

MIHQFLSE-------------KQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYISRK
....  ..              ....  . |    | ||.  ||   .....|..    ...| .| ...||   .    ||.  |  | .|  ..
vlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 7-184 2.4e-06 21.4 In-house 107-282 (290) alignment
Range on Protein: 7-184
Range on HMM: 107-282/290.0
VEDFWYMIYQEQIHLVYLMV-PDDKLKNTTTSLFNDENGGYQYTGKMFINNRRA-DVSGDPKEYTIEVLPEGNSDSVICQVHHHAPWKHLQQPPKTLPII
| |.| |. ||..  . ..    .. |      . ...|     |.. .      |   . .  |. |    .  . . . ..   |     .  || ..
vidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlall

KMIHQFlsekQVQNAGVCVVSLFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDY
....      .  .  | |    | ||. .|.    ... | .| | .. .... ... | . |.   ||  .  |..|.
rtlril....rkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 7-186 5.9e-06 20.2 In-house 98-294 (301) alignment
Range on Protein: 7-186
Range on HMM: 98-294/301.0
VEDFWYMIYQEQI-HLVYLMVPDDKLKNTTTSLFNDENGGYQYTGKMFINNRRADVSGDPKEYTIEV--LPEGNSDSVICQVHHH---APWKHLQ-----
. ||| .|.||.  ..| ..  ... |. ..  ... .   .. |.. .      |  |     . |      |  ... ... .   ..|. ||     
lvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtd

-------QPPKTlpIIKMIHQFLSEKQVQNAGVCVVS-LFGCGRACSFIGALYAINQLNNGIEPNICEIMKNIKQQRPGGVESFAQYASIYAIVFDYIS
       . |.|  ... |.. .  .|  . |  ||    . .|.  ..    .. |       .. .. | .....|| |    || ||| ..  |..
WpqdGvvreprt..vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq

subfamily_DSP23_pd Subfamily DSP23 98-179 8.2e-06 20.5 In-house 64-140 (148) alignment
Range on Protein: 98-179
Range on HMM: 64-140/148.0
PKTLPIIKMIHQFLSEKQVQNAGVCVVSLFGCGRACSFIgALYAINQLNNGiepnICEIMKNIKQQRPGGVESFAQYASIYA
| .|  .. . . . | . .|  | |  | | ||. ... | | . . .       .| . .....||| ||.. |   .. 
ppaleqvvefvrvveeaeekneavsvhcllgrgrtgtml.acylvkerkla....aaeaiaevrrlrpgsvetveqeklvrd