Gene ZK809.1 in Caenorhabditis elegans

Synonym: CELE_ZK809.1, ZK809.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP243_AA protein Get Run
CeleP243_AA_123-392 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 110-399 2.6e-115 379.0 In-house 3-295 (302) alignment 
Range on Protein: 110-399
Range on HMM: 3-295/302.0
KKKEKEKWSGEDASIKFKELrFNQSEggVRRDTeASCPN------RCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLP
...|||||..|....|. .  ....|  |....  .. .      .||........|...|....|.|........|.|.|.||..||..|.||.|.|||
veeekekWveeeeakklvks.ldtae..vkkef.kkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlp

KMDSVDAVEEFWRVVFHEQCQTVHIIARPEELTNpAIDKLFCQESGAWLYANGFFVNTRKVEKKENAKaDMFVVELLPEGCSNAVMCSVYLHTYWKPLFG
|.||.|.||||||.||.|....|.|....|||.. ....||...||...... .|||.|||||.|..| ...|.|.|||||||.|...||..|.||. ..
kvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkv

PDRFGAQIRAAHQI-AKNENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL--PSGH
|......|..|... ||.......|||.|.||.||..|.|||||. ..|..||||.|.|||..||.|||..|||..||||||.|....||.|.  |...
pvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeek
0036941 (Phosphotyrosine protein) phosphatases II 143-396 1.1e-50 168.0 In-house 26-282 (297) alignment 
Range on Protein: 143-396
Range on HMM: 26-282/297.0
EASCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDK
 .... .. ... . ..||..|. .|||.|....  ..||||.| .......  . . | |. .    ||.||| |........  . ...||  .  ..
lllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpn...tvedFWrmvweqnvtvIvmltelvelgrekcaq

LFCQESGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTYWKpLFG----PDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRN
 .  | | .|. ..|.|....||.....   ....|... |...  .. .. .| |   .|    |. . . |...... |. ....|... ...| || 
ywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp.dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

AALLTLAVVEDQLT---RGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLP
...... .. .||    . ... | |.|...|||||..| .. ||. ||.|  .|.|.||.
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0040438 (Phosphotyrosine protein) phosphatases II 147-397 1.4e-46 154.6 In-house 34-282 (317) alignment 
Range on Protein: 147-397
Range on HMM: 34-282/317.0
PNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDK
. .. ... . ..||..|. .|||.|.... ..    .|||| | ...|.... . . | |.    . || ||| |........  . ..||| ..  ..
tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl...pntvedFwrmvweqgvtvivmLteleelgrekcaq

LFCQesGAWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKN-ENGNSPTVIASVNGSGRNAAL
 . .  | .|. ..|.|.....|.  .|   ....|. . |.|. ... .. .| |     |. .   ..  ... .. |....|... ...| || ...
Ywpl..getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtf

LTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLPS
... .. .|| ..... . |.|...|||||..| .. ||. ||.| ....|.||..
iaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
0050432 (Phosphotyrosine protein) phosphatases II 140-395 3.5e-46 153.3 In-house 52-303 (308) alignment 
Range on Protein: 140-395
Range on HMM: 52-303/308.0
RDTEASCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQmCKDDYINGSKINVP--HFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTN
...  ... .. ... . ..||..|. .|||.|....  ..|||| | ....  ...  . . | |.    . || ||| |........  . ...|   
lsvkplleysvallpenkdkNrykdilpydhsRVkld.egsdYInAsyvdgyssklprkfIatqgPl...pntvedFwrmvweqnvrvIvmLtklvengr

PAIDKLFCQESG-AWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEnGNSPTVIASVNGSG
.  .. .  | |  .|. ..|.|.....|.  ..   ....|| . |...  .. .. .| |.    |. . . ..  ... |   ...|.|. . .| |
ekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvG

RNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
| .....| .. .|| ..... . |.|...|||||..| .. ||. ||.|  ...|.||
RtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0047943 (Phosphotyrosine protein) phosphatases II 144-391 2.3e-45 150.6 In-house 26-272 (273) alignment 
Range on Protein: 144-391
Range on HMM: 26-272/273.0
ASCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKL
 ... .. ... . ..||..|. .|||.|..... ..|||| | ........ . . | |. .    ||.||| |........  . ...|| ..  .. 
plltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpn...tvedfwrmvweqnvrviVmLtelvelgrekcaqY

FCQESGA-WLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGP---DRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNA
. .| |  .|. . |.|.....|.  ..   ....|| . |...  .. ....| |     |   . .   |...... .. ..|.|.|. ...| || .
wpleggelsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtg

ALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
....| .. ||| ..... . |.|. .|.||| .| .. ||. ||.|  ...
tfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 145-395 4.5e-44 146.5 In-house 45-293 (297) alignment 
Range on Protein: 145-395
Range on HMM: 45-293/297.0
SCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKD-----DYINGSKINVPHF-TPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNp
 .. .. ... . ..||..|. .|||.|........     |||| | ...... |. ... | |  .    || ||| |........  . ...|| . 
kpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe...tvedFwrmvweqgvtvivmLtklvelgr.

AIDKLFCQESGawlYANGFFVNTRKVEKKENAKADMFVVELlpEGCSnaVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEN---GNSPTVIASVNGS
  .. . .|.|   . ..|.|...|||.... .   . |.   .|.|   .. ....| |     |. .   ... ... .  .   .. |... ...| 
kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..nges..rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGv

GRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
|| ......  . .|| ..... . |.|...|||||..| .  ||. ||.|  .|.|.||
gRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0043336 (Phosphotyrosine protein) phosphatases II 145-391 2e-43 144.2 In-house 34-277 (278) alignment 
Range on Protein: 145-391
Range on HMM: 34-277/278.0
SCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAI
 .. .. ... . ..||..|. .|||.|.......    .|||| | ........ ... | |  .    || ||| |......|.  . ...|| ..  
ldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe...tvedFwrmvwelgvttivmLtelvelgrvkc

DKLFCqesGAWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNA
.. .    | .|. ..|.|...|.|.  ..   ... |. . |...  .. .| .. |     |. .   ..  ... .   . |.|... ...| || .
aqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTG

ALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
....| .. .|| ..... . |.|...|||||..| .  ||. ||.|  ...
tfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 124-393 2.5e-43 144.4 In-house 23-306 (307) alignment 
Range on Protein: 124-393
Range on HMM: 23-306/307.0
IKFKELRFNQSEGGVRRDTEASCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK-----DDYINGSKI--------NVPHFTPSIYLVQLPKMDsvdA
..|... . . |  ..  .. ... .. ... . ..||..|. .|||.|.... ..     .||||.| .        ......  . . | |. .    
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe...t

VEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGAWLYANGFFVNTRKVEKKENAKADMFVVELLpEGCSNAVMCSVYLHTYWKPLFGPDRFGAQ
||.||| .........  . ...||... ... . .| | .|. . |.|.....|.... .   . |. | .|...  .. .. .| |     |. |   
vedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeel

IRAAHQIAK--NEN-GNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKE---PKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKT
..  ... |  .|. ...|... .  | || ...... .. .|| ....   . . |.|...|||||..| .. ||. ||.|  .|...
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
DSPc_SM00195 145-389 5.6e-43 142.5 In-house 16-260 (263) alignment 
Range on Protein: 145-389
Range on HMM: 16-260/263.0
ScPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAI
. . ... ... .|.||......|||.|....  .    .|||| . |.... . .. . | |.    . ||.|||.|..|..... .. ..||  .  .
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekc

DKLFCQESGAWLYANGFFVNTRKVEKKEnAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG-NSPTVIASVNGSGRNA
|. . .|||     . . |....||||. ..  . ..||  ||....  . .| .. |.    ||     ..  ... | ..  ..|.|. . .| || .
drywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtg

ALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNW
...|. .. ..|...|...|.|||. .|.|||..|..  ||  .|.|   
tfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 145-389 5.6e-43 142.5 In-house 16-260 (263) alignment 
Range on Protein: 145-389
Range on HMM: 16-260/263.0
ScPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAI
. . ... ... .|.||......|||.|....  .    .|||| . |.... . .. . | |.    . ||.|||.|..|..... .. ..||  .  .
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiivmlteeeengkekc

DKLFCQESGAWLYANGFFVNTRKVEKKEnAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG-NSPTVIASVNGSGRNA
|. . .|||     . . |....||||. ..  . ..||  ||....  . .| .. |.    ||     ..  ... | ..  ..|.|. . .| || .
drywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtg

ALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNW
...|. .. ..|...|...|.|||. .|.|||..|..  ||  .|.|   
tfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0046845 (Phosphotyrosine protein) phosphatases II 145-395 9.1e-43 142.0 In-house 17-278 (284) alignment 
Range on Protein: 145-395
Range on HMM: 17-278/284.0
SCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQM-----CKDDYINGSKINVP-----HFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEE
... .. ... . |.||..|. .|||.|.....       .|||| | ....     .... . . | |. .    ||.|||.|........  . ...|
llslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn...tvedFwrmvweqnvrvIVmltelve

LTNPAIDKLFCQEsGAWLYANGFFVNTRKVEKKENAKADMFVVELLpeG-CSNAVMCSVYLHTYWKPLFGP---DRFGAQIRAAHQIAKNENGNSPTVIA
  .   .. . .| | .|. ..|.|.....|.|.. .  .. .. |  | ... ... .. .| |     |   . . . .|..... .| .|..|.|. 
ngrekcaqYwple.gevltygdftvtllseevkddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVH

SVNGSGRNAALLTLAVVEDQLTRGK---EPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
. .| || .....| .. .|| ...   .. . |.|. .|||||..| .. ||. .|.|  ...|.||
CsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 145-391 6e-42 139.4 In-house 38-286 (288) alignment 
Range on Protein: 145-391
Range on HMM: 38-286/288.0
SCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAI
... .. ... . ..||..|. .|||.|.....      .|||| | |......    . | |. .    ||.||| |........ .. ...|| .   
dltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn...tvedFWrmvweqnvrvIvmltklvelgrekc

DKLFCQesGAWLYANGFFVNTRKVEKKENAKADMFVVELL--PEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKN-ENGNSPTVIASVNGSGR
.. . .  | .|. . ..|.....|.... .   . |. |  ..|...  .. .. .| |     || . . ..  ... |  ..|..|.|. . .| ||
aqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgR

NAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
 .....| .. .|| ..... . |.|...|||||..| .  ||. .|.|  ...
tgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
Y_phosphatase Protein-tyrosine phosphatase 157-386 1.2e-41 138.1 Pfam-A 2-232 (235) alignment 
Range on Protein: 157-386
Range on HMM: 2-232/235.0
SSRNRHTDYKCYDHNRIIV-QMCK-DDYINGSKINVPHFTPSIYLVQLPKMDSVdavEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYA
...||..|. .||..|. . . ..  |||| . ..  . . .. . | |  ...   |.|||.|..|..... .... ||  . .... . .|..  |. 
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

NGFFVNTRkVEKKENAKADMFVVELLPEGCSNA---VMcSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVEDQ
. ..|... ...||. |. .. .  | . ...     . ... .| |.    |.   . ..  ... |.. . ..|.|. . .|.|| . ...| .. .|
gdikvelk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|....|... .||...|.|||..|.|. ||. ||.|
leaeeevdvlqivkelRkqRpgmvqsleqYiflyka
Y_phosphatase Protein-tyrosine phosphatase 157-386 1.2e-41 138.1 In-house 2-232 (235) alignment 
Range on Protein: 157-386
Range on HMM: 2-232/235.0
SSRNRHTDYKCYDHNRIIV-QMCK-DDYINGSKINVPHFTPSIYLVQLPKMDSVdavEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYA
...||..|. .||..|. . . ..  |||| . ..  . . .. . | |  ...   |.|||.|..|..... .... ||  . .... . .|..  |. 
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

NGFFVNTRkVEKKENAKADMFVVELLPEGCSNA---VMcSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVEDQ
. ..|... ...||. |. .. .  | . ...     . ... .| |.    |.   . ..  ... |.. . ..|.|. . .|.|| . ...| .. .|
gdikvelk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|....|... .||...|.|||..|.|. ||. ||.|
leaeeevdvlqivkelRkqRpgmvqsleqYiflyka
0040439 (Phosphotyrosine protein) phosphatases II 147-392 6e-39 129.5 In-house 2-247 (249) alignment 
Range on Protein: 147-392
Range on HMM: 2-247/249.0
PNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDK
. .. ... . ..||..|. .|||.|.... ...    |||| | |....... . . | |  .   .|| ||| .........  . ...|| .   ..
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe...tvedfwrmlwelgitvivmLtslvelgrekcaq

LFCQesGAWLYANGFFVNTRKVEKKENakADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEN---GNSPTVIASVNGSGRNA
 . .  | .|. ..|.|....||.|..    ....|| . .... ... .. .| |     |. |   ..  ... |  .    ..|... . .| || .
ywpl..ggsleygdftvtllsvevkdd..ytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

ALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
.....  . .|| . ..  . |.|...|.|||..| .. ||. ||.|  .|..
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0042113 (Phosphotyrosine protein) phosphatases II 150-391 3.9e-37 123.4 In-house 3-243 (245) alignment 
Range on Protein: 150-391
Range on HMM: 3-243/245.0
CKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFC
. ... . ..|| .|. .|||.|....  .    .|||| | ......|| ... | |  .    || ||| .......|.  . ..|||  .  .. . 
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqywp

QesGAWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEN--GNSPTVIASVNGSGRNAALLT
.  |  |. ..|.|.....|.  ...  ....|. ..|..   .. .|... |     ||     ... . . |  .  .| |... .  | || .....
l..gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfia

LAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
.  . .|| . ..  . |.|. .|.|||..| .  ||. ||.|  .|.
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 193-416 2.7e-36 118.9 In-house 113-335 (346) alignment 
Range on Protein: 193-416
Range on HMM: 113-335/346.0
FTPSIYLVQLPKMDSVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAiDKLFCQESGAWLYANGFFVNTRKVEKKENAKAdmFVVELLPEGCSNAVMCSV
|   . ..|||.|..   ||.|| ....|| . |...   . | | .   || .| | . |.  .|.| |. .   . |   . .|.|||| |..|.| |
fehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntt.tslfndenggyqytgkmfinnrradvsgdpke..ytievlpegnsdsvicqv

YLHTYWKPLFGPDRFGAQIRAAHQIAKNEN-GNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
. |. || |  | .    |.  ||.  ...  |    . |. |.||  ...      .||  | || | ||...|..||| .|.|. || |.|      |
hhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi

KTKLPSGHEVVS-KIKKFNEKATRSL
  |    .. |  .|..| .. .  .
arkrggkkapvnkdinrfidelaeis
0037934 (Phosphotyrosine protein) phosphatases II 149-391 3.4e-34 113.9 In-house 3-242 (243) alignment 
Range on Protein: 149-391
Range on HMM: 3-242/243.0
RCKMWQSHSSRNRHTDYKCYDHNRIIVQMckDDYINGSKINVPhftPSIYLVQLPKMDSVDA-VEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCqe
.. ... . |.||..|. .|||.|....   .||||.. |.|.   | ... |.|  ..|.  ...||| .........  . ...||.    ....   
siallpenlsknrysdilpydhsrvkleg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..

sGAWlYANGFFVNTRKVEKKENAKADMFVVELLP-EGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAK---------NENGNSPTVIASVNGSGR
 | . . ..|.|.. ..| ... .  ....| |. ....  |.   |... |     || .   ..  ... .         ......|...  . | ||
.gev.tygdftvtllseehlddytvrtlllenldlddltrlvi..hyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

NAALLTLAVVEDQLtrgkEPKISEIVRTIREQRPQ-SVDSYIQYVSLYMATNWLI
 ..|... .. ..|    .  . |.|...|||||. .| .. ||. ||.|  .|.
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 150-393 4.8e-26 87.2 In-house 27-274 (278) alignment 
Range on Protein: 150-393
Range on HMM: 27-274/278.0
CKMWQSHSSRNRHTDYKCYDHNRIIvqmckdDYINGSKINVPhfTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCqEsG
. .. .. ..|| .|. .|||.|..      |||| | |...  ..   . | |.    . |. ||| .........  ... .||..   .. .  | |
palylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlp...stvadfwrmlwelgitvivmltelvelgrekcaqywp.e.g

AWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTY-WKPLFGPDRFG---AQIRAAHQIAKNEN--------------GNSPTVIAS
 .|. ..|.|.. ..|  ..    .. |. |    ..     |. . | . | .|.  .      ...  .| .  .              .. |...  
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

VNGSGRNAALLTLAVVEDQLtrGKEPKISEIVRTIREQRPQ-SVDSYIQYVSLYMATNWLIKT
  | || ..|  .  . ..|  ..   . |.|...|.|||. .| .  ||. ||..  .|.. 
saGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPN23_pd Subfamily PTPN23 149-386 4.1e-24 79.9 In-house 36-275 (288) alignment 
Range on Protein: 149-386
Range on HMM: 36-275/288.0
RCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKI-NVPHFTPSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQE
 . . . .|..||..|   |||||. ..  |||||| | . ..   .|..   | |.  .   . .||..|.... ... ..  .||| .| .|. . ..
siaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqst...lnDFWlmvyeqkssviVmllskeelgkpkvdrYwPed

SGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVmCSVyLHTYWKPLFGPD---RFGAQIRAAHQ--IAKNENGNSPTVIASVNGSGRNAALL
 |.    . . |  ..|.. |.    .. .| |..   . | . .   | |  |  |.    . . . ....   |.... . | |.    |.||  .. 
kgetvkfgdlsvtlksvretethvervlkletldadavksv.shl.qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa

-TLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
   |.|..  ..   . | ..|...||||  .|    |.  .| |
lvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 157-387 9.9e-22 72.3 In-house 10-238 (250) alignment 
Range on Protein: 157-387
Range on HMM: 10-238/250.0
SSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPaIDKLFCQESgAWL
  .||..|.  .|. |....  |     |||| | ... . . .    | |    ....|.|||.|..|. .|. ...  .|  .  . . .  |  |  
keknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPl...qatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.aek

YANgFFVNTRKVEKKENAKADMFVveLLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEN--GNSPTVIASVNGSGRNAALLTLAVVEDQ
| .   |.  . |.. . .   ..  |  .  .. ..   . .. |     |.   | .   ... ....  ||.| ..   .| ||  | ...  | ..
yGd.vtvsllskeefadytkrklk..lskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

LTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
| . |   . ......|..||..|.|  |||..|.. 
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeii
subfamily_PTPN12_pd Subfamily PTPN12 123-397 3.5e-21 70.3 In-house 11-283 (290) alignment 
Range on Protein: 123-397
Range on HMM: 11-283/290.0
SIKFKELRFNQSeggvRRDTEASCPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVV
. .|..|.  ..    .  .|. ... .   ...  .||. |   ||..|. ..  .    .||||.. |. .. . .    | |     .....|||..
akefqklkklse....kykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLp...ktlddfWrmi

FHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYANGFFVNTrkvEKKENAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIA
.. . . | .. |  ||     .. . .| .  |  . | |..   |.... . |...  |  |  ..  .   . .| |     | ..   ..  ... 
weknveivvmaCrevelgkkkCerYWpeegeeelefgefevtl...eeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvr

K-NENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEP---KISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLPS
. .|. ..| |.    | ||  .....  | ..| ..| |   .. ..|...|.||.  | .  ||. .|.|   |....| .
elqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkelei
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 155-388 6.7e-21 69.8 In-house 55-287 (298) alignment 
Range on Protein: 155-388
Range on HMM: 55-287/298.0
SHSSRNRHTDYKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGA
.  ..||..|.  .|. |....      . |||| | ..  . ...  . | | .    .||.|||.| .|. .|. ..   ||| .  . | . .| |.
enkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlt...etvedFWrmvteedigtiVmltnleeldktkyhkywPde.gk

WLYaNGFFVNTRKVEKKENAKADMFVVELLPEGcsNAVMCSVYLHTYWKPLFGPDRFGAQIR--AAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVE
  | . . |. .. |.. .     . |.   |   .  .     .| |     |    . .   .  .  ....||.| ..   .| ||  .   .  | 
ety.geitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvl

DQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATN
... . .   . ..|...|..||..|..  ||| .|.|. 
ervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
subfamily_Ptp69D_pd Subfamily Ptp69D 157-387 3.9e-19 63.9 In-house 49-282 (307) alignment 
Range on Protein: 157-387
Range on HMM: 49-282/307.0
SSRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPkMDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGAWL
  .||. | | .|..|....      . |||| | |.  . . .    | | ...   ...|||..   . ... ...  .| ..  ..| . .|     
alknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdP.vea..tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devq

YAnGFFVNTRKVEKKENAKADMFVVELLP-EG--CSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQI-AKNENGNSPTVIASVNGSGRNAALLTLAVVE
|     |.. . ||...     . |     |.    .      | .| ||    |.   . ..  .|.   ... .|| |.   .|.|| . ...|... 
yg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsll

DQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
.||   .. .| |.|. .|.||.  |.|. ||| || | 
qqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral
subfamily_PTPRK_pd Subfamily PTPRK 155-386 9.2e-19 62.4 In-house 42-272 (314) alignment 
Range on Protein: 155-386
Range on HMM: 42-272/314.0
SHSSRNRHTDYKCYDHNRIIVQMCKDD----YINGSKINVpHFTPSIYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGA
 . ..|| .|   ||. |....  ..|    |||.. |.  .  |. ..|    ..  . |..|||.|..|.| .. ...   | ..    | . ...  
enreknrsgdilaydrsrvflitidgdpssdyinaalids.ykrpaafivtqgPlq..etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

wlYANgFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVVED
  | . . |.  ..| ...  . .| || |  | ..  .   . .. |     |    . ..  ... | .|... ..|.  ..|.||  . .....| |
..ygd.ikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivld

QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
 . | .   . ..|.|.|....  |.   ||. .| .
mieregvvdvfnavktlrsrkvnmveteeqykfiydv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 154-390 7.2e-18 59.7 In-house 46-282 (319) alignment 
Range on Protein: 154-390
Range on HMM: 46-282/319.0
QSHSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESg
.  ...||... . ||. |....  ..    |||| | |.  .        | |. .   ..|.|||.|..|.. .| ....  |  .  . |.. .|  
eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen...tiedfWrmvWeeessivvmltklveklkvklkkywpeen.

AWLYaNGFFVNTRKVEKKenakADMFVVELLPEGCSNAV---MCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG--NSPTVIASVNGSGRNAALLTL
 . |   . |.  . |..    .|. . .|  .  |. |   . . . .| |     |..  . .   ..|.|  ..  . | |.   .|.||  . ..|
feey.Grlivtleeeeel....edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivl

AVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWL
 .. ... .     . ..|...| ||.  |.   ||  .| |    
damlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_PTPRA_pd Subfamily PTPRA 156-386 7.7e-18 59.4 In-house 58-290 (330) alignment 
Range on Protein: 156-386
Range on HMM: 58-290/330.0
HSSRNRHTDYKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCqESGAW
   .||  .   ||..|.|... .     |||| | |.  .   .    | || .   .||.|||...  . .|. ...  .|  .    . .  . |..
nkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee...tvedfwrmiweqksativmltelkerkeekcaqywP.deGlv

LYANgFFVNTRKVEKKENAKADMFVVELLPEGC-SNAVMCSVYLHTYWKPLFG-PDRFGA--QIRAAHQIAKNENGNsPTVIASVNGSGRNAALLTLAVV
 | |   |. ....  ..     |.|. ||...  ...     .|    | .| |       .. .. .  .. ... | |.    | ||  ....|  |
tyGn.irvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldav

EDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
 ...   .   . |.|. .| |||| | .  ||. .| .
lervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykv
PTPc_DSPc_SM00012 290-387 1.1e-17 59.5 In-house 2-103 (105) alignment 
Range on Protein: 290-387
Range on HMM: 2-103/105.0
CSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGN---SPTVIASVNGSGRNAALLTLAVVEDQLTRG-KEPKISEIVRTIREQRPQSVDSYIQYVSLYM
...| .| |.    |..  . ... ... ||.| .   .|.|. . .| || . . .|... .||... ||..|..||. .|.|||..|... ||. ||.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AT
| 
al
subfamily_PTPN13_pd Subfamily PTPN13 149-392 1.9e-17 58.4 In-house 28-270 (273) alignment 
Range on Protein: 149-392
Range on HMM: 28-270/273.0
RCKMWQS--HSSRNRHTDYKCYDHNRIIVQMCKDdYINGSKINVPHfTPSIYLVQLPKMDSVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQ
.|.. ..  . ..||. .   ||. |....     ||| | |.||      |   . .    ..|..||..|.  ... . ...   |  .   .. . .
tcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpv.gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPe

ESGAWLYANG-FFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYlhTYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLA
. .  | ... . |.  ||.|... .   . |. .  | |. |.   .  . |     |      .. . .... .. ..| |.    | ||  .|.|. 
sknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnf..vkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitid

VVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
|| . . | || ...||||..||||   | .  ||.  | |.  ..|
vvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 138-415 2.9e-17 57.7 In-house 29-306 (318) alignment 
Range on Protein: 138-415
Range on HMM: 29-306/318.0
VRRDTEASCPNRCkMWQSHSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPE
. |..| .   .  . .    .||...   ||| |. .|| ..    |||| . |.  . . .    | |     ...|.|||.|.  ..... .... |
lsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlp...etieDfWrmvWeqnsavivmltqee

ELTNPAIDKLFCQeSGAWLYANgFFVNTRKVEKKENAKADMFVVELlpEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE--NGNSPTVIAS
| .   ... . . .|.  | .   |. ..  . ..     | |.   .....  .   | .| |     |.  .  .    |. | .  .|..|.|.  
ergkakvhryWPs.kgsrsygk.lvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhC

VNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLP--SGHEVVSKIKKFNEKATRS
  | ||    ... .. ...   .   . ..|...||||.  |    ||. .| .    ...  .  . ... |.|....|. . |
saGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreqdpes
subfamily_CG7180_pd Subfamily CG7180 149-385 4.5e-17 56.6 In-house 35-284 (296) alignment 
Range on Protein: 149-385
Range on HMM: 35-284/296.0
RCKMWQSHSSRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVpHFTPSIYLV-QLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNpAIDKL
.. . .    .||. .   ||.||....      |.|||| . ..  .  .  |.| . || .   .|.||||.|. |....| ..... . ..    . 
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvds.flkkkeyivteapkke...tvdefWrlvydeeisavvvLtktfdfak.mypsy

FCQESgAWLYANgFFVNTRKVEKKENAKADMFVVELL--------PEGCSNAVMCSVYLHTYWKP-LFGPD---RFGAQIRAAHQIAKNE---NGNSPTV
. ..|    | . .||.. ....  | |  .| .            .   .  .. ..  | |.     |     .   .| .... ..    . ..|.|
wpnks.keqyge.ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

IASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYM
. | .|..|  . |.. .  ... . .|  . | |.|.|..||| |..  .|  .| 
vvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYd
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 150-383 9.7e-17 55.8 In-house 27-251 (267) alignment 
Range on Protein: 150-383
Range on HMM: 27-251/267.0
CKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVpHFTPSIYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARpeeLTNPAIDKLFCQESG
. . .    |||  |   ||..|.|..  ...||| | ..  . |   ..|    ..   .. .|. |. .... .. .. .        | ...  . |
qsiaeknqernrlddnlpyddtrvilrtkeeeyinasyveg.yktknafivtqdplk..ntitdfltvihdqkvpvivlltk...vftdnirlfwPPkmg

AWLYANGFFVNtRKVEKKENAkADMFVVELLPEGCSnAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTlavVED
     . . |. . .||.||   .. ..||  .  | |   ..| .  |.       .   . .     . |||| | |.|  .| ||  ..|.   .. 
qakkyqdltve.hslekeend.yqiitlelkfknes.ahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflv...ids

QLTRGKEPKISEI---VRTIREQRPQSVDSYIQYVSL
|| | |.  .|.|   .| ||.||.  ||.  .|. .
qleraktegvsdifdflrkirsqriglvdtkeryiyi
subfamily_PTPN3_pd Subfamily PTPN3 156-381 1.9e-16 54.9 In-house 41-265 (280) alignment 
Range on Protein: 156-381
Range on HMM: 41-265/280.0
HSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPS---IYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWL
  |.||. |   ||. |....  . |||| . .|.   . .    |..    ..  .....||..|........ ...   |       . . ...  . 
nlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPla..ktatdfWqmvweqksslivmlttlverGrvkChqyWPetedele

YAnGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHtyWKPLFGPDRFGAQIRAAHQIAKNENG-NSPTVIASVNGSGRNAALLTLAVVEDQL
|. .| |. .| .....     .|..   .  .. ..   ||   |     ||     ..  ... |  .| ..|.|.    | ||   |..| .    .
yg.efsvkcekedetksyvlrelvlkdketkeerkilqlqyla..WpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalali

TRGKEPKISEIVRTIREQRPQSVDSYIQYV
 . ..  . .||||.|.||   |..  || 
eaaepvypldivrtmrdqramlvqtasqyk
subfamily_PTPRD_pd Subfamily PTPRD 156-388 2.5e-16 54.4 In-house 48-278 (564) alignment 
Range on Protein: 156-388
Range on HMM: 48-278/564.0
HSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHfTPSIYLV-QLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGA
  ..||  .   |||.|.. .. .     |||| | |.  . ..  |.  | |.    ...|.||| |. ....|. .. . || ..  ..| . .. | 
NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPla...etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.gt

WLYaNGFFVNTRKVEKKENAKADMFVVelLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVVED
  | ... |.  . |....     | .    .  |.. .   . .| |     |.   . ..  ... . ||... |.|.   .| ||  . ... .. .
ety.geltVtleeeeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamle

QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATN
...  |   | ..|...|.||.  |..  ||. .. | .
rikeektvDiyqyvkalrkqRnamVqteeQYiFiheail
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 157-387 3.7e-16 54.0 In-house 48-275 (288) alignment 
Range on Protein: 157-387
Range on HMM: 48-275/288.0
SSRNRHTDYKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLVQLPKMDSVdavEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWL
 ..||. .   ||..|. ..      . |||| | |.. . .      | | .|.|   ..||..|. .. .|.  ..   |  .   .. . ..    .
akknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtv...ndfWelvyenktstivmltelveggktkCeeYWPdadkpkn

YANgFFVNTRKVEKKENAKADMFVVEllpeGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGN-SPTVIASVNGSGRNAALLTLAVVEDQL
| . . |  ......|.     . .|       . .    | .. |     |.     .   .|.  ... .  | ..   .| ||    ..|  . |..
yGs.vtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidav

TRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
 . .   . ..|  .|.||.. |.   ||. .| . 
eeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 154-387 2.2e-15 51.3 In-house 42-273 (315) alignment 
Range on Protein: 154-387
Range on HMM: 42-273/315.0
QSHSSRNRHTDYKCYDHNRIIV----QMCKDDYINGSKINVPHFTPSIYLVQLPKMDSVDaveEFWRVVFHEQCQTVHIIARPEEltNpaiDKLFCQESG
.   ..||. .   .|..|...    .  ..|||| |.|.  .   .    | |.  |||   .|||.|..|.  |. ...  .|  .   ||. |.   
tinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvd...dfwrmvlqekvttivmvtkkqe..g...dkikcrqyw

AWLYANGFFVNTRKVEKKE-NAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVV
    |.     . |||  . .| .|. . .|      .    . .  | |     . . .. ..  ...   |.. . . ..  . | ||   ....  |
PdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidev

EDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
 .|. |..   . ..|...|..||. | .  .|  .| | 
vaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydav
subfamily_PTPRB_pd Subfamily PTPRB 153-392 9.9e-15 49.3 In-house 48-286 (293) alignment 
Range on Protein: 153-392
Range on HMM: 48-286/293.0
WQSHSSRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQES
 .  ...||.|.   |||.|. ..      ..|||| . |.  . .      | |  ..   |..|||.|. ...... .. .  |      .. . ...
lavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet...vddfWrmvwekkssiivmltqlvekgkvkCeeYWPade

GAWLYANgFFVNTRKVEKKENAKADMFVVELlpegCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIA---KNENGNSPTVIASVNGSGRNAALLTLA
 . || .   |.  . |..|.     . .|      ..      | .| |     |..  . ..  ...    .... ..|.|.    | ||  ....| 
epvlyGd.ikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfiald

VVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
 . .....     |  ||  .||.| . | .  ||. .. .   |..
rllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 158-387 1.5e-14 49.2 In-house 27-251 (284) alignment 
Range on Protein: 158-387
Range on HMM: 27-251/284.0
SRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHfTPSIYL-VQLPKMdsvDAVEEFWRVVFHEQCQTVHIIArpeeltnpaidKLFCqeSGAWL
 .|| ..   .|.|.. ..        |||| | |.     .  |.  | |.    .....|||...  .| |. ...           |  |  |  | 
dknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPld...ntladfWrmiweyncstivllt...........kdkc..sqywp

YA-----NGFFVNTRKVEKKENakadmFVV---ELLPEGCSNAVMCSVYLHTYWKPLFG-PDRFGAQ---IRAAHQIAKNENGNSPTVIASVNGSGRNAA
       . | |.   ||. |.     .||   ||  .|  . .      |    |  | ||        ..  . . . ||.... |.    |.||  .
lkivikeerfkvkvdsveesee.....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgv

LLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
 ..| |. |.. . |   . ..|| .|.||.. |....||  .|.| 
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 158-387 2.1e-14 48.6 In-house 63-287 (319) alignment 
Range on Protein: 158-387
Range on HMM: 63-287/319.0
SRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVpHFTPSIYL-VQLPKMdsvDAVEEFWRVVFHEQCQTVHIIArpeeltnpaidKLFCqeSGAWL
 .|| ..   .|.|.. ..        |||| | ..  .  .  |.  | |.    .....|||...  .| |. ...           |  |  |  | 
dknriinilafdknvvklerliGeefsdyinasfvtG.yqrkdkyiaaqGPld...ntladfWrmiweyncstivllt...........kdkc..sqywp

YAN-----GFFVNTRKVEKKENakadmFVV---ELLPEGCSNAVMCSVYLHTYWKPLFG-PDRFGAQ---IRAAHQIAKNENGNSPTVIASVNGSGRNAA
         | |.   ||. ..     .||   ||  .|  . .      |    |  | ||        ..  . . . ||.. . |.    |.||  .
lkivikeerfkvkvdsveetae.....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGv

LLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
 ..| |. |.. . |   . ..|| .|.||.. |....||  .|.| 
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 154-385 3.2e-14 47.6 In-house 45-272 (287) alignment 
Range on Protein: 154-385
Range on HMM: 45-272/287.0
QSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGawLY
..   .|| |.   .| .|.... ...|||| . |.  .      . . |    .... .||... ... ... .... .| .. .  . . .|.   ..
sqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPm...fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vv

ANGFFVNTRKVEKKENAKADMFVVELLPEgCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE--NGNSPTVIASVNGSGRNAALLTLAVVEDQL
   . ..  . |....     . |.   .  ..  .   |  | |.      .. . .   ..  |..  .||.. |.   .. || | ..  |.  .. 
lGeyniellneevnagyierklevknknk.agdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkc

TRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYM
 .     . ....  | |.|.||    ||  .. 
kteGviDvfqvlksqriqkpgsvqtveqykfind
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 157-388 3.4e-14 47.7 In-house 52-281 (297) alignment 
Range on Protein: 157-388
Range on HMM: 52-281/297.0
SSRNRHTDYKCYDHNRIIVQMCKDD----YINGSKINVPHFtpSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPEELTNpAIDKLFCqESGAWL
 ...|...   || .|.....  ||    |.| | ... .    .   | |. ..   |..||..|..|| .|. ...  .| ..    . .  ..|   
feksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkat...vadfWamvldeqvstivmlnddnerdk.kcaryWs.dkgvtt

YANgFFVNTRKVEKKENAKADMFVVEllPEGCSNAVMCSVYLHTYWKPLFGPD--RFGAQIRAAHQIAKN--ENGNSPTVIASVNGSGRNAALLTLAVVE
. .   | .  |...|      ..|.   .   .  .   | ...|     .   .  . .   ... |.  .| ..| ..  ..| || . |||.  | 
fGd.vsvvllsvsereGfikrelevt..kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv

DQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATN
 .  | ||  | ..|. .|..||. |    ||  .| | .
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 157-386 4.3e-14 47.3 In-house 9-236 (239) alignment 
Range on Protein: 157-386
Range on HMM: 9-236/239.0
SSRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARpeeLTNPaiDKLFCQEsgAWL
 ..||...   |||.|....      . |||| | .     .|  |.     .    .  .|||....|.   . ...    | .    |  |..   | 
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcvei..ssgdfwrmmwqerrcvivmltg...lieg..hkkkchq..ywp

YANGFFVNTRKVEKKENAKADMFVVELLPE--GCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVED
 .   ..| |   .| .  ||  .  ..    | ..      |  | |     |.   | .   ..|.|.   |  | ||    | ||  |.| .  .  
dstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|  . |   | . |..|||.||. |..  ||| ...|
qakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 157-386 4.3e-14 47.3 In-house 8-235 (239) alignment 
Range on Protein: 157-386
Range on HMM: 8-235/239.0
SSRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARpeeLTNPaiDKLFCQEsgAWL
 ..||...   |||.|....      . |||| | .     .|  |.     .    .  .|||....|.   . ...    | .    |  |..   | 
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcvei..ssgdfwrmmwqerrcvivmltg...lieg..hkkkchq..ywp

YANGFFVNTRKVEKKENAKADMFVVELLPE--GCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVED
 .   ..| |   .| .  ||  .  ..    | ..      |  | |     |.   | .   ..|.|.   |  | ||    | ||  |.| .  .  
dstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|  . |   | . |..|||.||. |..  ||| ...|
qakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 151-384 9.7e-14 46.1 In-house 36-270 (307) alignment 
Range on Protein: 151-384
Range on HMM: 36-270/307.0
KMWQSHSSRNRHTDYKCYDHNRIIVQM--CKDDYINGSKINVPHFTPSIYLVQLPKmDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQES
. ... . .||..| || |..||.|..     |||    . .      .   | |. ..  .. .|| ..  |. ..| ....  ||..   .. .  | 
eafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgpl.en..tqysfwamaiqekvesvimlckvielakikceqywplee

GAWL-YA-NGFFVNTRKVEKKENAKADMFVvELLPEGCSNAVMCSVYLHTYWKPLfgPDRFGAQI--RAAHQIAKNENGNSPTVIASVNGSGRNAALLTL
|  | .. ..  ..  ..  |. |  . .. ..       |  .    |  |.    |||   ||   |   .   .  . | |.    | ||  .....
gqklvfgeapntisvanlgakklapdedli.nvttlkvdwaqksrtiqhlqwenw..pdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivai

AVVEDQLTRGKEPK-ISEIVRTIREQRPQSVDSYIQYVSLY
..| |.. .|.. | . ..|. .|.||. .. . .||. |.
slvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylh
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 158-384 1.1e-13 45.5 In-house 58-276 (290) alignment 
Range on Protein: 158-384
Range on HMM: 58-276/290.0
SRNRHTDYKCYDHNRIIVQMCK-DDYINGSKINvpHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYANG
 .||. |  | |  |.|..     ||.    ..     . . | | .  |   .| ..||.| .|.  .. ..    |  ..  .. . ...|  |    
kknrykdvvcndktrvilkdGydGdyvhanyvk..GlkamfiltqGalkd...tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe

FFV-NTRKVEKKENAKADMFVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAKNengNSPTVIASVNGSGRNAALLTLAVVEDQLTRGK
. |  . . .| .| .  .. |    .| .  .    .    |     .    | .|  . . |    . | |.    | ||  .. .. |  . |. ||
itvlcseeddkdaniikktlsvrdkdsGkehklk..hlkikswpdksvalstlallrtlrilrka...sGpvvvhcsaGiGrtGtfvaievglqilldGk

EPKISEIVRTIREQRPQSVDSYIQYVSLY
| .. ..||..|. | .||.  |||. | 
eldlldlvralrnsrlnsvqvdiqylalv
subfamily_PTPN14_pd Subfamily PTPN14 149-386 1.2e-13 45.8 In-house 42-291 (300) alignment 
Range on Protein: 149-386
Range on HMM: 42-291/300.0
RCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKD---DYINGSKINVPHFTPS-IYLVQLPKMdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLF
 .   .   ..||. |   |..||. .. .|.   .||| |.|.|.  . .  |.|    .    .|..||..|. .. | . .... ||  .    | |
staklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl..eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyf

CQE--SGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYlhTYWKPLFGPD------RFGAQIRA----AHQIAKNENGNSPTVIASV
 ..  .   .  . | | |. .|. .   .  . .. || .    |.   |  | |     |.       .  ....    ...  .... . | ..   
Pkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCs

NGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
.| ||   |..  ..   |  ..| .| ......||||   |..  ||  .| .
aGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkv
0041856 (Phosphotyrosine protein) phosphatases II 158-391 1.9e-13 45.9 In-house 3-171 (182) alignment 
Range on Protein: 158-391
Range on HMM: 3-171/182.0
SRNRHTDYKCYDHNRiivqmcKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIArpEELTNPaidklfcqesgawlyangf
..||..|. .|||.|        |||| . .  .. .  . . | | ..    |..|.| . .....|.  ..  ||| .|                   
dknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls...tvadflrmlkelgittivnlt..eelywp...................

fvntrkvekkenakadmfvvellpegcsN--AVMCSVYLHTYWKPLFGPDrFGAQIRAAHQIAKnenGNSPTVIASVNGSGRNAALLTLAVVEDQltrgk
                            .    .   ||.. |     || .   ..  ... .    . |...    | || ..|  . ... .     
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....

EPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
.  . |.|...|..||..| .  ||. |..|  .|.
gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 150-392 2.2e-13 44.9 In-house 37-273 (288) alignment 
Range on Protein: 150-392
Range on HMM: 37-273/288.0
CKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESG
 . . . ..|.|...  . |  |. ..   | ||.   .   ..   .   | |      ..||.|....... . . ....  |.  .. .. |  . |
idsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPl...ngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG

AWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTyWKPLFGPDRFGAQIRAAHQIaknENGNSPTVIASVNGSGRNAALLTLAVVED
     . .   ..|  .  .    . ..    ||  . ..  ..|.  |.    |. . . .|  . .   .. . | |. | .|.|| ..|    .. .
ekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlle.WdddgvPenylsplrllevl...kslqkPivvhssaGvGrtgtlililiale

QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY-MATNWLIK
.|       | ...   ||.| ... .  ||. .. .  . |. 
slrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_PTPN1_pd Subfamily PTPN1 147-364 2.4e-13 44.5 In-house 23-244 (290) alignment 
Range on Protein: 147-364
Range on HMM: 23-244/290.0
PNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQ
| |    ..  ..||. | . ||| ||...  . |||| | .....   |  | | |  .   .|. ||..|.......| .. .  |  .    . . |
ptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpn...tvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

ESG-AWLYA--NGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAK---NENGNSPTVIASVNGSGRNAA
.     |      . |.  . |.|.. .  .. .| |    .  ..   . .| |  .  |.  .| ..  ... .     .   |.||    | ||  .
geeekellledtklkvkliseerksyytvrllelenlktqetreil..hfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

LLTLAVVEDQLTRGKEPKI---SEIVR
.  .  .  .. . .. .    .. . 
fclvdtclvliekkddlssvdikkvll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 154-387 2.8e-13 44.1 In-house 45-275 (439) alignment 
Range on Protein: 154-387
Range on HMM: 45-275/439.0
QSH-SSRNRHTDYKCYDHNRIIVQ----MCKDDYINGSKINVpHFTPSIYLV-QLPKMdsvDAVEEFWRVVFHEQCqtVHIIArpeeLTNPAIDKLFCQE
|..  ..||. |   .|| |...|    . .  |||   |.  .... .|.  | ||    .....|||.|.....  |.|.     |||      .   
qeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikG.yyddklyiatqgpkk...ettddfwrlviekkt..vtivm....ltnlvesykywps

SGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSvYLHTYWKPLFGPDR--FGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLA
..   | .      |..|  . .   . |..    .  .  .   . .. |     | .  .  .   | . |....   | |.    | ||  ....| 
daevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlq.fhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiiald

VVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
.  .||   ..  |  ||. .|.|| | |..  ||| .| | 
ialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 153-393 4e-13 44.2 In-house 43-285 (305) alignment 
Range on Protein: 153-393
Range on HMM: 43-285/305.0
WQSHSSRNRHTDYKCYDHNRIIVQMC--KD--DYINGSKINVPHFTPSIYLVQLPkMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQES
 . . ..||...   .|..|||..    .|  |||| | ..  .   .  . | | ..  . |..|||....|. .|. ....  |  .    . . .. 
keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgP.lk..ntvadfWrliveekvstivmltklveggkdkCrqYWpesk

GAWLYANGFFVNTRKVEKKENAKADMFVVELlPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGN--SPTVIASVNGSGRNAALLTLAV
.     . | |. .  .. ..     . .    .. ..    . |  | |     |.  .. ..  ... |. . .   | ..   .| ||  . ... .
tekkefgefsvelksektasdyieRklkisi.ededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdi

VEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKT
  ..| . ..  . |.....|..|.. | .  |||.|. | . ||..
alerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 243-395 5.9e-13 43.0 In-house 180-342 (347) alignment 
Range on Protein: 243-395
Range on HMM: 180-342/347.0
LFCQESGAWLYANGFFVNTRKVEKKENAKADM--FVVELLPEGCSNAVMCSVYLHTYWKPLFGPDR---FGAQIRAAHQIAK-----NENGNSPTVIASV
.|  |.  .|  .|...|||.||  . .|. |  . ||.. ||||.| .. ||  | |     ||      | .||  . .      | .  .| |.   
ffpletdhylnlkgwlintravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcd

NGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
 |  | |...  ... .|.  || |   .. . .|.||       | |     |. . .| ||
lgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyairaalfylklkl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 155-391 6.8e-13 43.4 In-house 40-276 (281) alignment 
Range on Protein: 155-391
Range on HMM: 40-276/281.0
SHSSRNRHTDYKCYDHNRIIV----QMCKDDYINGSKINVPHfTPSIYLV-QLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESG
    .||...   ||. |. |    .  . |||| . ..  .  .  |.. | |     .....||..|. .. ... ...|  |  .    . . ... 
envlknrYsnivaYDatrvkvtpneenkntDYinanfvpgyk.gekeyiatqgPvP...aslvafWqmvweqkvsaivmvtreieagklkChrYWPddns

AWLYANGFFVNTRKVEKKENAkADMFVVeLLPEGCSnaVMCSVYLHTYWKPLFGPDRFGAQIRAAHQI--AKNENGNSPTVIASVNGSGRNAALLTLAVV
.  |..    .|.. ||.. .    | .    .| .  .  .   .| |     |.   . .   ...  ..... . | ||    | ||  . ..|  .
elkygdvtvkstaeeekatyi.erkfkl.eresget..reveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrl

EDQLTRG-KEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
 .....  .| .....|. .|..|   | . .||  .| |    .
vkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN9_pd Subfamily PTPN9 150-386 7.2e-13 43.2 In-house 36-285 (297) alignment 
Range on Protein: 150-386
Range on HMM: 36-285/297.0
CKMWQSHSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFC
. . .. ...||.||  |||. |. ..  ..    |||| . ..  .   ..   | |      .|..|||.|. ... .. ...| .|       . . 
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkk...tvsdfWrmvWeqevlvivmttrvvergrlkcgqyWp

QESGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCsvYLHTYWkPLFGPDRFG-------AQIRA-----AHQIAKNENG---NSPTVIA
.|...      . |.. .||..|. |  .....   .. |  |.   .  . | | .|  . .        ..|      .........|   . | |. 
leeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvth..fqflsW.PdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvh

SVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
   | ||  .. || .  ..| .    .. | |...|.||  |.    ||.  |.|
csaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 158-384 1.3e-12 42.4 In-house 5-232 (237) alignment 
Range on Protein: 158-384
Range on HMM: 5-232/237.0
SRNRHTDYKCYDHNRIIVQMC--KDDYINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYAn
 .||. . ..|||.|.... .  . |||| . ..    ||  |.     ..|  . ..||..|. |.|  . ...   |  .    | . .      |  
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgples..scddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg.

gffVNTRKVEKKENaKADMFVVELLPE---GCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG---NSPTVIASVNGSGRNAALLTLAVVED
   | |  . |||.  .|  |  ||        .  .   |  | |     |..  | .|  ..| .. .     .| .|    | || . .| .  .  
...vltvslkkkee.fsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY
|    |   | . | .| |.||  ...  ||| ..
qakekkvvdiynyvysieedrpyiiqtkdqyvfih
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 153-386 1.4e-12 42.2 In-house 32-265 (285) alignment 
Range on Protein: 153-386
Range on HMM: 32-265/285.0
WQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAwL
...    ||..| .| .  |....    |||  | . .|    | |.     .   ... .||.....|.   | ...   |         . .. |  .
yeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgpl..petlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge.v

YANGFFVNTrKVEKKENAKADMFVVELLPEGCSNAVMCSVYLH----TYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVE
   | .  |   | ||.| |   .  |      .|    .|.      .|   . |.     |   . . | .  . | ..    | || |... .    
vkfgkyeit.lteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyat

DQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
 ..    . .. .||| .|  | |.|.|..|.. ||. 
irimenpniemldivremramrfqavqshmqflflyvv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 155-386 1.6e-12 41.5 In-house 44-231 (392) alignment 
Range on Protein: 155-386
Range on HMM: 44-231/392.0
SHSSRNRHTDYKCYDHNRIIV----QMCKDDYINGSKINVPHFTPSIYLVQLPKMDSVDaveEFWRVVFHEQCQTVHIIARPEELTnpaidklfcqesga
    .||. .   || .|...    .. ..||.| | |.  .   .    | |.. |.|   .|||.||.|.  |. .... .|                
inlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasld...dfwrmvfqenvttiamvtklkegd..............

wlyangffvntrkvekkenakadmfvvellpeGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNS-PTVIASVNGSGRNAALLTLAVVED
                                   .|  .. .  | |     | .  . ..  ...  .    . | .|    | || . ....  |  
................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvva

QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
.  . .   . ..|  ||..||  |..  ||  .| |
hakktrmvdvfnfvtnirrkrpymvqtkeqyafiyga
subfamily_PTPN6_pd Subfamily PTPN6 113-394 1.7e-12 41.9 In-house 19-300 (306) alignment 
Range on Protein: 113-394
Range on HMM: 19-300/306.0
EKEKWSGEDASIKFKELRFNQSEGGVRRDTEAScpnrckmwQSHSSRNRHTDYKCYDHNRIIV---QMCKDDYINGSKINVPHFTP-SIYLVQLPKMdsV
|.|. . .. . .|.||. ....  . |.  |         ..  ..||.     .||.|.|.   ..  .||||.. |.    .    |.     .   
eeeslekagfeeefeelqqeeakkllsrkegak........penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcl..e

DAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYANGFFVNTRKvEKKENAKADMFVVE-LLPEGCSNAVMcsVYLHTYWKPLFGPDRF
. |..|||.|. |... . .. .  | ..    . . .|.    | .    |... ..... .   ..|.    ....  |.   | .. |     |   
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevf..qyhfksWPdhgvpkdp

GAQIRAAHQIAKNEN-----GNSPTVIASVNGSGRNAALLTLAVVEDQLTRG---KEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTK
|| .   ... ....      . |.|.   .| ||  ... . .. .....     .  | ..|...|||| . |    ||  .|.| .  |.||
gavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 157-386 2.8e-12 41.2 In-house 50-274 (315) alignment 
Range on Protein: 157-386
Range on HMM: 50-274/315.0
SSRNRHTDYKCYDHNRIIVQM----CKDDYINGSKINVPHfTPSIYL-VQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsgAW
  .||. .   ||. |. . .     . ||.| . |.     .  |.  | |.   | .|..|||.||.|.. .. ...   |  .   .| .  .    
kqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpn...vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kv

LYanGFFVNTRKVEKKEnakaDMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKN--ENGNSPTVIASVNGSGRNAALLTLAVVED
.|  | .  ||| |...    . . |  |     . .   | ||    |  |  ..   .   .. .|   .|  .. |.   .| ||  ...||  | |
iy..Gkitvtrkseevn....teytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavld

QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|.   .   . .... .|..| . |..  ||  .| |
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 154-395 4.9e-12 40.2 In-house 47-292 (305) alignment 
Range on Protein: 154-395
Range on HMM: 47-292/305.0
QSHsSRNRHTDYKCYDHNRIIVQM-CKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNP-AIDKLFCQESGAW
| .  .||. |  | |.||. ..     .||    .  |  .  .   | |  .   .  .|| . . .. ... ..    |      .. . ...    
qea.gknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplek...tcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvl

LYANG------FFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHtyWKPLfgPDR--FGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLT
 . ..       |  . ... ...|||..   .|. ||  . .      |  |     |||    |..     ..|      |.|.    | ||  ... 
efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyh..widw..pdrgvpaadlailellekarpskgpivvhcsagigrtgsvvm

LAVVEDQLTRGKEPK-ISEIVRTIREQRPQSVDSYIQYVSLYM-ATNWLIKTKL
|  . |||  |.  .    |.. ||||| .|...  ||. ..    |.. | ||
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl
subfamily_PTPRN_pd Subfamily PTPRN 154-386 5.3e-12 40.1 In-house 54-287 (297) alignment 
Range on Protein: 154-386
Range on HMM: 54-287/297.0
QSHSSRNRHTDYKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLV-QLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCqES
.   ..||...   |||.|. ..      |.|||| | |       ..|.  | |     . | .||..|... .  .  ..| ||    . .. .  . 
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgpl...astvadfwqmvweqGvvvivnltrleeegvkqckrywp.de

GAWLYANgFFVN--TRKVEKkENAKADMFVVELLPEGCSNAVmcSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNS-PTVIASVNGSGRNAALLTLA
|. .|   . |.  . ..   ..     | .  |    . .|  . . .  |.    |    . .    .. |   | | | |. . .|.||  . . . 
Gsevyhi.yevhlvsehiwc.ddylvrsfylknlqtsetrtv..tqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilid

VVEDQLTRG-KEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
.| ..|..| ||  |.  .  .|.|||. | .  |.   ..|
lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 154-387 1.3e-11 39.1 In-house 26-264 (274) alignment 
Range on Protein: 154-387
Range on HMM: 26-264/274.0
QSHSSRNRHTDYKCYDHNRIIV--QMCKD---DYINGSKINVPHFTPSIYLVQLPKMdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQES
  ....||...    .. |...  .  .|   .|||   |  .. .  .|.     .  . .|..|||....|..| . .... .|  .    . | .. 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPl..pntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdae

GAWLYA--NGFFVNTRKVEKKENAKADMFVVEllpeGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIA---KNENGN-SPTVIASVNGSGRNAALL
.. .    ... ....|. .... .   .|..     ...   .  |..| |     ||.  . ..  ...    ..|| . .|.|.    | ||  . .
dyeiserygdveikvekiverndysvrklvlk....ylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi

TLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
.  .   || . .   . .||  .| .|   |..  ||  .. | 
aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihral
subfamily_PTPRG_pd Subfamily PTPRG 155-394 1.4e-11 38.4 In-house 46-290 (563) alignment 
Range on Protein: 155-394
Range on HMM: 46-290/563.0
SHSSRNRHTDYKCYDHNRIIVQMCKD-----DYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQeSG
.   .||...   ||. |. ..   .     |||| . |.  . .      | |     | .. |||... .. ... .|.  .| ..   |  . .  .
enkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk...dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.de

AwLYANGFFVNTRKVEKKENAKADMFVVEL--L--PEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQ-IAKNENGNSPTVIASVNGSGRNAALLTL
. .  . . |.  . |..       .|..   |   . | .  .   |  |.|     |.    ..  ...  | |..   |.|.   .| ||   .. |
s.etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivl

AVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTK
  .  |. . .   . .....|| ||.  | .  ||. |. |   .|..|
dtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 155-387 2.8e-11 38.1 In-house 47-284 (325) alignment 
Range on Protein: 155-387
Range on HMM: 47-284/325.0
SHSSRNRHTDYKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPeELTNPAIDKLFCQESGA
   ..||  .   .|..|....  ||    |||| | ..           | |. ..   ....||.|.  .|  | ..    .| .    . . .| | 
enkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltat...indlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgk

WLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCsvYLHTYWKPLFGPDRFGAQIRAA------H-QIAKNENGNSPTVIASVNGSGRNAALLT
     |. |. | .|.  .    .. |    .| . .|    . .  |. .  . |  . |         . ..  | .. .| ..  ..| ||  ....
sktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkq..fqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

LAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
|  . ...    .  | . |. .|..||. |..  ||. .| | 
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal
0036282 (Phosphotyrosine protein) phosphatases II 180-384 2.8e-11 38.9 In-house 2-163 (174) alignment 
Range on Protein: 180-384
Range on HMM: 2-163/174.0
DDYINGSKINVPHFTPSIYLVQLPKMdsvdaveeFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQesgawlyangffvntrkvekkenakadmfvvel
.|||| | ... . || ... | |          ||. .......||    ...|| .  .  ..                                   
sdyinaspldlsyitprliagqgpla........fwemlkelgittvvmlleekelglykcinywpe.................................

lpEGCSNAVMCSVYLHTYWKPLFGPDRFG--AQIRAAHQIAKNeNGNSPTVIASVNGSGRNAALLTLAVVEDQLTrGKEPKISEIVRTIREQRPQSVDSY
     .   .   ||.. |     ||       ....... .. ... |...    | || ..|  .  .. .|   .  .. ..||..| |||..| . 
..lredlerlgiqylylpwpDhgvpdlsillefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

IQYVSLY
 ||  ||
sQyrfly
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 158-386 2.9e-11 37.2 In-house 45-271 (515) alignment 
Range on Protein: 158-386
Range on HMM: 45-271/515.0
SRNRHTDYKCYDHNRIIV----QMCKDDYINGSKINVPHFTPSIYLVQLPKMDSVDaveEFWRVVFHEQCQTVHIIARPEELtnpaiDKLFCQESGAWLY
..||. .   || .|...    .  . ||.| |.|.  .   .    | |.  |||   .|||.|..|.  |. .... .|      ||  | .      
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd...dfWrlvlqenvttiamvtklkeg.....dkikcgkyWPdkp

ANGFFVNTRKVEK-KENAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVVEDQL
..     . |||    .| ...   .|     ...     .  | |     | .  . ..  ...   ... . | .|    | ||   ....  |  . 
gdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

TRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
  ..   . ..|. ||..||. |    ||  .| |
kttrmvdvfnfvtnirqkrpylvqtqeqyafiyga
0043147 (Phosphotyrosine protein) phosphatases II 180-390 3e-11 38.8 In-house 5-160 (172) alignment 
Range on Protein: 180-390
Range on HMM: 5-160/172.0
DDYINGSKINVPHFTPSIYLVQLPkmdSVDAVEEFWRVVFHEQCQTVHIIARPeeltnpaidklfcqesgawlyangffvntrkvekkenakadmfvvel
.|||| | ..... ....   | |       ...||| . .......  . .                                                
sdyinasyldlyyipdrfiatqgp...lrntladfwrmlkelgithivnltel...............................................

LPEGCSNAVMCSVYLHTYWKPLFGPdRFGAQIRAAHQIAK--NENGNSPTVIASVNGSGRNAALLTLAVVEdqltrgKEPKISEIVRTIREQRPQSVDSY
|  .     .   ||...|     |  .   ... ..| .  ... . |...  . | || ..|  .  ..      .  .. |.|...||.||..| . 
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

IQYVSLYMATNWL
 ||  ||.  ..|
sqyrflyyfekll
subfamily_egg_pd Subfamily egg 158-407 3.7e-11 37.3 In-house 42-286 (307) alignment 
Range on Protein: 158-407
Range on HMM: 42-286/307.0
SRNRHTDYKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLY
 . |    .| |  |. ...      ||.|   ...   .     | | |     ..|..|||.|| |..| . ...   |  .       ...  . . 
ekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplk...ntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtv

ANGFFVNTRKVEKKENAKADMFVVELlpEGCSnavMCSVYLHtYWKplfGPDRFGAQIRAAHQI-AKNENGNSPTVIASVNGSGRNAALLTLAVVEDQLT
  .. ... ||..| .    .  . |   |         .|  .|.   |  .. ...    ..  |  |   |.|. ...|  . |.|... .   .| 
pGslrienlkvdskadplfrvtklkl..vGgd...deerfle.hwq...gdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsll

RGKEPK--ISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLPSGHEVVSKIKK
||   |  . . |  .| .|. ||.| ..|. .|    ....  . | .|.    ..
rGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdyer
0046846 (Phosphotyrosine protein) phosphatases II 193-392 3.7e-11 38.6 In-house 15-174 (176) alignment 
Range on Protein: 193-392
Range on HMM: 15-174/176.0
FTPSIYLVQLP---KMDSVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLyangffvntrkvekkenakadmfvvellpegcsnavm
 .....|  .|     . .. ...|.. ........|  .  . ||    .. .. .. .. .                                     
inanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................................

csVYLHTYWKPLFGPDRfGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEDqltrGKEPKISEIVRTIREQRP-QSVDSYIQYVSLYMATN
   |||. |     ||   . ...  .| .  . . |...  . | || ..|. .  .|     .|  .. |.....||||| ..| .  ||  ||..  
..qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefel

WLIK
.|.|
lllk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 146-384 2.4e-10 34.8 In-house 23-259 (283) alignment 
Range on Protein: 146-384
Range on HMM: 23-259/283.0
CPNRCKMWQSHSSRNRHTDYKCYDHNRIIVQMCKDDYINGSKINVPHF--TPSIYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKL
 .  ... . .   ||. .   .| .|. ..    |||| . | | .       |..    .|  ..| .||..||.|.  .. ....  |  . .  . 
ldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPld..rtvvdfWkmvfdekitaivmltklqedlrikCsqy

FCQEsGAWLYANgFFVNTRKVEKKENAKADMFVVELlPEGCSNAVMCSVYLHTYWkPLFGPDRFGAQIRAAHQIA--KNENGNSPTVIASVNGSGRNAAL
. .. |.  | . | |  ||   ..      ...      . .... . |    |   .|..     .    ..   ..|. ..| |.   .| || |..
WPkr.GsedyGe.ftvtlrkettsnsfiikelllrv.nssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf

LTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY
.....  ...       . ..|. .||||.  | .  ||  ..
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvh
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 150-384 3.3e-10 34.3 In-house 40-276 (290) alignment 
Range on Protein: 150-384
Range on HMM: 40-276/290.0
CKMWQSHSSRNRHTDYKCYDHNRIIVQ------MCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKL
 .. .| . .|| ...  || |||...       |...||| . |.  .   . ...| | ..    . .||... .|..  . ..    |  .    . 
vgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn...tlvdFWkliwqekvtiivmltniieegkvkCqqY

FCQESGAWlyANGFFVNTRKVEKKENAKADMFVVELLPEGcSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK--NENGNSPTVIASVNGSGRNAAL
. ... .    . | ..  . |. ..     . |.   ..  .. .   |  | |..        . . . ... |    .|| . |.   .. || | .
Wpdsdtka..ygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavf

LTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY
...|.  ..        . ..... | |.|.|| .  ||  ..
caaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgif
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 156-392 1.8e-09 31.8 In-house 38-278 (287) alignment 
Range on Protein: 156-392
Range on HMM: 38-278/287.0
HSSRNRHTDYKCYDHNRIIVQMCK---DDYINGSKInvPHFT-PSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGAW
  ..||..|   .|..|...        ||||   .  . .|    ...    . .  .| .|||.|....  .| ...|  | .   . | . .     
avkknryadvlPiddtrvllsaegelGsdyinanyv..asytddeafiaaqgPiaa..tvrdfwravletrsasvitmtreveearlkcykywPer.evP

LYANGFFVNTRKVEKKENAkADMFVVELLPEGCSN-AVMCSVYLHTYWKPLFGPD-----RFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLA
.   |. |   . ..||     .  . |.     .  |.  . | .. .    |      ||  ...   ..|.. ..  | |.    | ||   ||.. 
mrvGGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatl

VVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
|. ..|    .  .. .|  .||.|   | . .|.  || |     |
vlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
0049260 (Phosphotyrosine protein) phosphatases II 211-385 2.2e-09 32.7 In-house 22-144 (152) alignment 
Range on Protein: 211-385
Range on HMM: 22-144/152.0
VEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFcqesgawlyangffvntrkvekkenakadmfvvellpegcsnavmcsVYLHTYWKPLFGPDRFGAQ
...||| . . ...|.  . ...||. .  ....                                                |||..|     ||     
ladfwrmlkelgittivmltellelgklkceqyi...............................................qylhlpwpDhgvpdlsqll

IRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVVEdqltrgKEPKISEIVRTIREQRPQSVDSYIQYVSLYM
. . . | | ... . |...  . | || ..|  .  ..      .  .. |.|. .||.||..| .  |.  || 
lflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 155-391 3.8e-09 30.9 In-house 19-264 (270) alignment 
Range on Protein: 155-391
Range on HMM: 19-264/270.0
SHSSRNRHTDYKCYDHNRIIVQMCKDD----YINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGA
 ..  ||..|     . |....  ..|    |||   ..  .  .  |.     ...  ....|||....|. ... ...  ||  .   .. . .|.. 
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpt..tlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

WLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFG---------AQIRAAHQIAKNENGNSPTVIASVNGSGRNAAL
 .  .  .......... .    .  ..|  .| .. ..   . .. |     | . .         . .|| ..  |. . ..|...   .| ||   |
kvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

LTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
..|  .   | . |.  . .|.. .|..|.. |.   ||  || |    .
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 154-384 4.7e-09 30.3 In-house 53-282 (305) alignment 
Range on Protein: 154-384
Range on HMM: 53-282/305.0
QSHSSRNRHTDYKCYDHNRIIVQ-MCKDDYINGSKINVPHFTPSIYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWL
.   ..||..|  | |.. . ..     |||    . .|      ...    .|  ....||| .| ... . . ....  || .    . .    |  |
diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpld..qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

YA-NGFFVNTRKVEKKENAKADMFVVeLLPEGCSNAVMCSVYlHTYWKPLfgPDRF--GAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVED
   .|  |.     |  .  |.. .  ||    |     ||  |  |     |||    ... .   ..     . | |.    | ||  .....  . .
elksgivvenvsgskpmerdaeiqit.llnltysgdqkmsvr.hlqwtew..pdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyile

QLTRGKE-PKISEIVRTIREQRPQSVDSYIQYVSLY
...  |. | . |.|...|.||  |... .||. ..
kiaenkpcppmpelvkalrdqrafsiqndvqylfih
0049772 (Phosphotyrosine protein) phosphatases II 157-393 2.4e-08 29.6 In-house 47-282 (314) alignment 
Range on Protein: 157-393
Range on HMM: 47-282/314.0
SSRNRHTDYKCYDhNRIIVQM---CKDDYINGSKINVPhftPSIYLVQLPkMDSVdaVEEF----------WRVVF--HEQCQTVHI-------------
 ..||..|  ..| || |..       |||| | .. .    .    | | .. .  |. |          ||.|.    .. ....             
rdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgp.leit..vvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------IARPEELTnpaidklfcqesgawlyaNGFFVNTRKVEKkenakadmfvvELL--PEGCSNAVmcSVYLHTYWKPlFGPDrFGAQIRAAHQIA
        . .. ...                  |   . . .  |           | |  || .....    ||.. .   ....   ...... .. 
daAlgKtpllildgng..................neptaadlellk...........eelydpelferlg..ikylripvpD.gsap.lledfdeflefi

KNENGNSPTVIASVNGSGRNAALLTLAVVEDQLtrgKEpKISEIVRTIREQRP-----QSVDSYIQYVSLYMATNWLIKT
.. . ..|...    | || . ....| .  .|   .   . |... .|..||      .. ...||.  ..| . ..|.
eeadkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 157-384 1e-07 25.9 In-house 38-262 (281) alignment 
Range on Protein: 157-384
Range on HMM: 38-262/281.0
SSRNRHTDYKCYDHNRIIVQM-----CKDDYINGSKINVPHFTPSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAW
  .||...  | |  |. ...        |||    |  | .     | | || ..     .|||....|.  .. ....  |       . | ... . 
nkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkket...radfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

LYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNavMCSVYLHTYWKPLFGPDRFGAQIRAAHQIaknENGNSPTVIASVNGSGRNAALLTLAVVEDQL
|  . . |.        |       ..|  || .   . . .|   |     |.     ..  ..|       .| ||    | ||  .|... .  . .
lqfdklsvsyedstv..nkslvttrlnlsyegetr..lithwlwkewpdwqvpessevmlkilrki...rarstppvihcsagvgrsgtlmaveialqsi

-TRGKEPKISEIVRTIRE-QRPQSVDSYIQYVSLY
 ..   | | .||  .|   |  ||..  ||. ..
hshftlpdikqivshlrvtgraasvqtlqqymliw
0051429 (Phosphotyrosine protein) phosphatases II 180-393 1.3e-07 27.1 In-house 4-227 (272) alignment 
Range on Protein: 180-393
Range on HMM: 4-227/272.0
DDYINGSKINVPhftP-----S-IYLVQLPKMDSvdaVEEFWRVvFHEQCQTVHIIARPEELTNPAIDKLFC----------QESGAWLYANGFFVNTRK
..||| . .. .           .|. . |   .   ...|||   .... |.  . ..||.     |..             .|  .   . ..| . .
sgyiNardvggy...grvvkpgrlyrsggplplt...aadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtlls

VEKKENAKADMFVVELL-PEGCSNAVMCSVYlhTYWKPLFGPDRFgaqIRAAHQIAKNengNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPK----
.| ...   ......|| . | .  ||. .|  | |     |.     .... ..  .   . | ..    | .| . .  |  .  ....    .    
eellldyilrellltlllsagearevmhlhy..tdwpdhgvpqea...llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll

----ISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKT
    . |.|. .|.|||..| .. ||. ||.|   |...
tnlyleeaveelraqrpgavqteeqylflyeallellrs
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 147-243 2.8e-06 21.2 In-house 31-130 (301) alignment 
Range on Protein: 147-243
Range on HMM: 31-130/301.0
PNRCKMWQSHSSRNRHTDYKCYDHNRIIV------QMCKDDYINGSKINVPHFTPSIYLVQLPkMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAI
..  .. ....  ||. . . ||.||||.      ..|. .||| | |.    .      | | |.    . .|||....|. ... ...  .| |.   
sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgp.mk..ktlvdfWrliwqekpvsivmvtnlkegtkskc

DKL
 . 
eqy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 323-386 2.9e-06 21.4 In-house 227-290 (297) alignment 
Range on Protein: 323-386
Range on HMM: 227-290/297.0
GNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
 | ....    | ||   ..   |. ..| ... |..  |.. .||||.. | .  |.  || |
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 154-234 3.3e-06 21.2 In-house 29-112 (297) alignment 
Range on Protein: 154-234
Range on HMM: 29-112/297.0
QSHSS--RNRHTDYKCYDHNRIIVQ--MCKDDYINGSKINVPHFTPSIYLVQlPKMDSVDAVEEFWRVVFHEQCQTVHIIARPEE
.  ||  .||..|   .| .|. ..  . . ||||   .  |.    .. .   .    ..|..||..|.... ... ..|. .|
krnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyil.aqGplsatvddfwtlvaeqdvrvivmvaklqe
0051082 (Phosphotyrosine protein) phosphatases II 188-386 4.9e-06 21.7 In-house 6-148 (151) alignment 
Range on Protein: 188-386
Range on HMM: 6-148/151.0
INVPHFTPSIYLVQLPkmdsvdaVEEFWRVVFHEQCQTVHIIARPEELTnpaIDKLFCQESGawlyangffvntrkvekkenakadmfvvellpegcsna
||    |. .|. . |        ..|.. . .....|.  .  .||      .. ...| |                                      
infsyvtgglyrsggp.......ladflellkelgiktivnlrseeerg...ycpeylpelg......................................

vmcS--VYLHTYWKPLFGPDRFGAQIRAAHQIAKNeNGNSPTVIASVNGSGRNAALLTLAVVEDQltrgkePKISEIVRTIREQRPQSVDSYIQYVSLYM
      ....    | .| . . .......... . ..| |...    | || ..|  |  .  .        . |... .|..|| .| .  |.. ...
...ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

A
|
a
0048076 (Phosphotyrosine protein) phosphatases II 275-390 6.2e-06 21.5 In-house 34-142 (145) alignment 
Range on Protein: 275-390
Range on HMM: 34-142/145.0
FVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEDqltrgKEPKISEIVRTIREQRPQSV
. .   .|.... ..   ||.. |     || .   ... ..| .  . . |...    | || ..|  . ..       .   . |... .|.|||..|
lnltselellerlgi..qylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgav

DSYIQYVSLYMATNWL
 .  |.  ||..  .|
pnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 276-387 6.9e-06 21.4 In-house 33-141 (144) alignment 
Range on Protein: 276-387
Range on HMM: 33-141/144.0
VVELLPEGCSNAVMCS--VYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEdqlTRGkePKISEIVRTIREQRPQS
|. | .|   . . .    |||. |     || .   ... . | .  . . |...    | || ..| .. ..    ..|    . |... .|..||..
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpga

VDSYIQYVSLYMAT
| .  |.  |..  
vpnpgqlrfLleye