Gene DDB_G0285459 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DdisDSP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP003_AA protein Get Run
DdisP003_AA_123-240 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 110-237 2.5e-78 253.0 In-house 1-128 (128) alignment 
Range on Protein: 110-237
Range on HMM: 1-128/128.0
QNFFAANPTLGESRTNQTWGDIIDPQLVPQDKLEEYASTISSWSADKLPQRMRDYHNILLTERELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKAL
| || ||| .||  ||.|.||.|||.|.|.|.|.|||.|.|.|||||||.|.|||.||||.|||||.||||||||||||||||.||||||.||.||.|||
qtffnanpqfgefgtnvtlgdlidpnllpeddlkeyaltlsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkal

EWDFAIAGRDINFSNRWSAQWYCLYLNY
|||.||||||||.|||..||||||||..
ewdyaiagrdinisnrfaaqwyclylqv
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 112-238 3.4e-78 252.6 In-house 2-128 (128) alignment 
Range on Protein: 112-238
Range on HMM: 2-128/128.0
FFAANPTLGESRTNQTWGDIIDPQLVPQDKLEEYASTISSWSADKLPQRMRDYHNILLTERELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALEW
|| ||| .||  ||.|.||.|||.|.|.|.|.|||.|.|.|||||||.|.|||.||||.|||||.||||||||||||||||.||||||.||.||.|||||
ffnanpqfgefgtnvtlgdlidpnllpeddlkeyaltlsdwsadklpyrirdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkalew

DFAIAGRDINFSNRWSAQWYCLYLNYV
|.||||||||.|||..||||||||..|
dyaiagrdinisnrfaaqwyclylqvv
0049772 (Phosphotyrosine protein) phosphatases II 148-241 3.7e-13 45.4 In-house 187-279 (314) alignment 
Range on Protein: 148-241
Range on HMM: 187-279/314.0
TISSWSADkLPQRMRDYHNILLTErELPTVLYVHCECGCDRTGE-VMASYVMKFKGWDLPKALEWDFAIAGRDINFSNRWSAQWYCLYLNYVENY
 .. .||. |.. ...  .....  . .....|||  |..|||  | | |.||  |..| .|||.  ..    .|.. . . . |. .|.....|
pvpDgsap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefilealley
0048076 (Phosphotyrosine protein) phosphatases II 150-211 2.3e-11 39.0 In-house 56-117 (145) alignment 
Range on Protein: 150-211
Range on HMM: 56-117/145.0
SSWSADKLPQRMRDYHNILLTERELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALEW
  ...  |.. ...  ... . .. . . .|||  |..||| ..| |.|. .|..|..|||.
pDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealel
0051082 (Phosphotyrosine protein) phosphatases II 132-233 2.8e-11 38.7 In-house 48-145 (151) alignment 
Range on Protein: 132-233
Range on HMM: 48-145/151.0
IDPQLVPQDKLEEYASTISSWSADKLPQRMRDYHNILLTEREL-PTVLYVHCECGCDRTGEVMASYVMKfKGWDLPKALEWDFAIAGrdinFSNRWSAQW
 .|...|.  .| .   | .|.. .||.    . ..|   ..  . ...|||  |..||| ..| | |.  |..| .|||.  .. .     . . . |.
ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrp....gvvqpnqqf

YCL
...
lfq
0048179 (Phosphotyrosine protein) phosphatases II 150-211 5.2e-11 38.0 In-house 58-119 (144) alignment 
Range on Protein: 150-211
Range on HMM: 58-119/144.0
SSWSADKLPQRMRDYHNILLTERELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALEW
  ...  |.. ...  ... . .| . . .||| .|..||| ..| |.|| .|..| .||..
pDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealal
0041856 (Phosphotyrosine protein) phosphatases II 152-211 1.7e-10 36.3 In-house 87-145 (182) alignment 
Range on Protein: 152-211
Range on HMM: 87-145/182.0
WSADKLPQrMRDYHNILLTERELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALEW
|  .  |  ... .... . .| . . .||| .|..||| . | |.|| .|..|..|...
wpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavkl
0044763 (Phosphotyrosine protein) phosphatases II 149-211 2.8e-10 35.6 In-house 83-146 (178) alignment 
Range on Protein: 149-211
Range on HMM: 83-146/178.0
ISSWSADKLPQRMRDYHNILLTER-ELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALEW
|. ...  |.. ... .... . . | . . .||| .| .|.| ..| | ||  |..|..|.|.
ipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaiel
0042113 (Phosphotyrosine protein) phosphatases II 158-211 3.3e-09 32.0 In-house 154-217 (245) alignment 
Range on Protein: 158-211
Range on HMM: 154-217/245.0
P---QRMRDYHNILLTERE--LPTVLYVHCECGCDRTGEVMASYVM-----KFKGWDLPKALEW
|   . . | ...... ..   .....|||  |..||| ..| | |     | .|..|..|...
pdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavke
0040439 (Phosphotyrosine protein) phosphatases II 150-211 1e-08 30.6 In-house 148-220 (249) alignment 
Range on Protein: 150-211
Range on HMM: 148-220/249.0
SSWSADKLPQRMRDYHNILLTERE------LPTVLYVHCECGCDRTGEVMASYVM-----KFKGWDLPKALEW
 .|  ...|. . |  ...   |.       .....|||  |..||| . | | |     | .|.||. |...
tdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkl
0040438 (Phosphotyrosine protein) phosphatases II 149-211 1.3e-08 30.0 In-house 179-250 (317) alignment 
Range on Protein: 149-211
Range on HMM: 179-250/317.0
ISSWSADKLPQRMRDYHNILLTEREL----PTVLYVHCECGCDRTGEVMASYVM-----KFKGWDLPKALEW
  .|  ...|. ...  ..|   ||     .... |||  |..||| . | |.|     | .|.|...|...
ytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavke
0039614 (Phosphotyrosine protein) phosphatases II 151-211 1.3e-08 30.2 In-house 192-263 (297) alignment 
Range on Protein: 151-211
Range on HMM: 192-263/297.0
SWSADKLPQRMRDYHNILLTERE------LPTVLYVHCECGCDRTGEVMASYVM-----KFKGWDLPKALEW
.|  .. |. ...  ..|   ||       ... .|||  |..||| . | | |     | .|.|...|...
gwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavke
0043336 (Phosphotyrosine protein) phosphatases II 151-211 2e-08 29.5 In-house 182-251 (278) alignment 
Range on Protein: 151-211
Range on HMM: 182-251/278.0
SWSADKLPQRMRDYHNILLTERE----LPTVLYVHCECGCDRTGEVMASYVM-----KFKGWDLPKALEW
.|  ...|  . .. ..| . ||     .....|||  |..||| ..| |..     | .|.||..|...
gwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavke
0051429 (Phosphotyrosine protein) phosphatases II 124-211 3.3e-08 29.1 In-house 102-199 (272) alignment 
Range on Protein: 124-211
Range on HMM: 102-199/272.0
TNQTWGDIIDPQLVPQDKLEEYASTISSWSADKLP-QRMRDYHNILLTerelPTVLYVHCECGCDRTGEVMASYVMKfKGWD--------------LPKA
    .  ..  .| ... .| .  .  .|  .  | . ...  ..||.    .  ..|||  |.|||| | | . .   |..              | .|
dyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleea

LEW
.|.
vee
0043147 (Phosphotyrosine protein) phosphatases II 161-211 3.3e-08 29.0 In-house 84-135 (172) alignment 
Range on Protein: 161-211
Range on HMM: 84-135/172.0
MRDYHNILLT--ERELPTVLYVHCECGCDRTGEVMASYVMKfKGWDLPKALEW
...  ... .   ..   . .|||  |..||| . | | |. .|..| .|...
lleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeaval
DSPc Dual specificity phosphatase, catalytic domain 155-210 3.5e-08 28.4 Pfam-A 53-108 (133) alignment 
Range on Protein: 155-210
Range on HMM: 53-108/133.0
DKLPQRMRDYHNILLTERELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALE
.|. . ...  ... . ..     .|||..|  |.. ... | || |...| .|.|
tkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye
DSPc Dual specificity phosphatase, catalytic domain 155-210 3.5e-08 28.4 In-house 53-108 (133) alignment 
Range on Protein: 155-210
Range on HMM: 53-108/133.0
DKLPQRMRDYHNILLTERELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALE
.|. . ...  ... . ..     .|||..|  |.. ... | || |...| .|.|
tkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye
0049260 (Phosphotyrosine protein) phosphatases II 171-211 3.6e-08 28.7 In-house 85-124 (152) alignment 
Range on Protein: 171-211
Range on HMM: 85-124/152.0
ERELPTVLYVHCECGCDRTGEVMASYVMKfKGWDLPKALEW
 ..   . .|||  |..||| ..| | |. .|..| .|...
aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeaval
0045450 (Phosphotyrosine protein) phosphatases II 151-211 6.5e-08 28.1 In-house 204-278 (307) alignment 
Range on Protein: 151-211
Range on HMM: 204-278/307.0
SWSADKLPQRMRDYHNILLTERE------LPTVLYVHCECGCDRTGEVMASYVMKFKG--------WDLPKALEW
.|  ...|. . .  ...   |.       ... .|||  |..||| ..| |.|.  .        .||..|...
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkl
0045098 (Phosphotyrosine protein) phosphatases II 158-211 6.9e-08 27.7 In-house 173-245 (278) alignment 
Range on Protein: 158-211
Range on HMM: 173-245/278.0
P--QRMRDYHNILLTERE--------------LPTVLYVHCECGCDRTGEVMASYVMKFK---GWDLPKALEW
|  . . .. . ..  ..               ... .|||  |..||| . | | |.     |.||..|...
pilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavke
0038934 (Phosphotyrosine protein) phosphatases II 171-211 7.2e-08 27.8 In-house 111-151 (194) alignment 
Range on Protein: 171-211
Range on HMM: 111-151/194.0
ERELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALEW
..  . | .|||  |  ||| . |.| ..  |... .|...
nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAial
0036282 (Phosphotyrosine protein) phosphatases II 158-211 1.1e-07 27.3 In-house 86-141 (174) alignment 
Range on Protein: 158-211
Range on HMM: 86-141/174.0
PQrMRDYHNILLTEREL--PTVLYVHCECGCDRTGEVMASYVMKFKGW-DLPKALEW
.. ...  ... . ..     ...|||  |..||| ..| | |.  .. .| .||..
si.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldl
0046846 (Phosphotyrosine protein) phosphatases II 164-211 1.1e-07 27.3 In-house 98-146 (176) alignment 
Range on Protein: 164-211
Range on HMM: 98-146/176.0
YHNILLTERELPTVLYVHCECGCDRTGEVMASYVMKF-KGWDLPKALEW
  ... . ..   . .|||  |. ||| . | | ..  ||... .||..
llefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealal
0037934 (Phosphotyrosine protein) phosphatases II 166-211 1.4e-07 26.9 In-house 164-215 (243) alignment 
Range on Protein: 166-211
Range on HMM: 164-215/243.0
NILLT-----ERELPTVLYVHCECGCDRTGEVMASYVMKFK-GWDLPKALEW
...        .    ...|||  |..||| . | |.|. . |.|| .|...
efieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkl
PTPc_motif_SM00404 158-210 3e-07 25.4 In-house 63-115 (140) alignment 
Range on Protein: 158-210
Range on HMM: 63-115/140.0
PQRMRDYHNILLTERELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALE
 . ..   ... . ..  .  .||| .|  |.. ... |.|. ....| .|.|
skyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeaye
0036941 (Phosphotyrosine protein) phosphatases II 151-211 1.3e-06 23.4 In-house 177-251 (297) alignment 
Range on Protein: 151-211
Range on HMM: 177-251/297.0
SWSADKLPQRMRDYHNILLTERE------LPTVLYVHCECGCDRTGEVMASYVM--------KFKGWDLPKALEW
.|  ...|. .... ...   |.       ... .|||  |. |.| . | ..|        | .|.|...|. .
gwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkk
0047943 (Phosphotyrosine protein) phosphatases II 151-211 1.4e-06 23.4 In-house 175-246 (273) alignment 
Range on Protein: 151-211
Range on HMM: 175-246/273.0
SWSADKLPQRMRDYHNILLTERE------LPTVLYVHCECGCDRTGEVMASYVM-----KFKGWDLPKALEW
.|  .. |. . .  ...   |.       ... .|||  |. ||| . | ...     | .|.|...|. .
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkl
0050432 (Phosphotyrosine protein) phosphatases II 150-211 1.8e-06 23.0 In-house 205-273 (308) alignment 
Range on Protein: 150-211
Range on HMM: 205-273/308.0
SSWSADKLPQRMRDYHNILLTEREL--PTVLYVHCECGCDRTGEVMASYVM-----KFKGWDLPKALEW
 .|  .. |. .... ..|   |.   . . .|||  |. ||| . | ...     | .|.|...|. .
tnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkk
0051299 (Phosphotyrosine protein) phosphatases II 150-210 2.1e-06 22.9 In-house 190-259 (288) alignment 
Range on Protein: 150-210
Range on HMM: 190-259/288.0
SSWSADKLPQRMRDYHNILLTEREL----PTVLYVHCECGCDRTGEVMASYVM-----KFKGWDLPKALE
 .|  .  |. .... ..|   |.     . . .|||  |..||| . | ...     | .|.|...|..
tnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavk
PTEN_1 176-211 2.2e-06 22.6 In-house 131-166 (196) alignment 
Range on Protein: 176-211
Range on HMM: 131-166/196.0
TVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALEW
 | .|||  |  |.| | |.| |. ....  .|||.
nvVlVHCkaGlgRsGtvvaayLmykgkltadeAlel
subfamily_PTPMT1_pd Subfamily PTPMT1 171-210 2.3e-06 22.2 In-house 103-142 (171) alignment 
Range on Protein: 171-210
Range on HMM: 103-142/171.0
ERELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALE
....   .||||. |  |.. . |.|.|| . ... .||.
vaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlk
subfamily_RNGTT_pd Subfamily RNGTT 171-211 4.3e-06 20.5 In-house 109-149 (189) alignment 
Range on Protein: 171-211
Range on HMM: 109-149/189.0
ERELPTVLYVHCECGCDRTGEVMASYVMKFKGWDLPKALEW
...  .|. |||  | .||| ...||... . |.. .|.. 
kknpeevigvhCthGfnRtGFlivsyLvekedwsveaaval
0046845 (Phosphotyrosine protein) phosphatases II 151-210 5.8e-06 21.4 In-house 174-247 (284) alignment 
Range on Protein: 151-210
Range on HMM: 174-247/284.0
SWSADKLPQRMRDYHNILLTEREL------PTVLYVHCECGCDRTGEVMASYVMKFK--------GWDLPKALE
||  .. |. ..|  ..| . |||      . .  |||  |. ||| . | ....          |.|...|. 
swpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavk