Gene DDB_G0267992 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP004_AA protein Get Run
DdisP004_AA_77-242 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0046846 (Phosphotyrosine protein) phosphatases II 79-225 1.7e-21 72.2 In-house 12-152 (176) alignment 
Range on Protein: 79-225
Range on HMM: 12-152/176.0
TNWIVKDSILCGeYPGNKDDDIV--HFKTLSTLLDSGIRVFVCLQEQDELKKFRPYreDILKLSKEKGIdvdsvTFVHFPIEDGGIAENnEDLVDLIERL
 ..|. . ||.. .|. .. ...  . . |  |.. ||.. |.|.|  ||.... .  .. .. .. ||     .. |.|..|.|. .  |.| .|.| .
ldyinanlilgs.rpiatqgplprtladflemlkelgitavvnlteevelgrlkcp..nywpeleklgi.....qylhlpwpDhgvpdl.elllellefi

LNLLSLDNKVYLHCWAGRGRTGIIGACLLGRL-YQVTGLEALRRTQDCYQ
 . |. ...|. ||.||.|||| . |..| .| .... .|||.. ...  
realkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRp
0051429 (Phosphotyrosine protein) phosphatases II 71-230 1.6e-17 59.5 In-house 11-210 (272) alignment 
Range on Protein: 71-230
Range on HMM: 11-210/272.0
DMKGPldtTNWIVKDSILCGEYPGNKDddivhFKTLSTLLDSGIRVFVCLQEQDELKKFRPYREDilklskekgidvDSVTFVHFPIEDGGIAENN----
|..|.   ....... .... .| . .      . . .| . ||.. |.| . .|....  .|.               ....|.||.| .  . .    
dvggy...grvvkpgrlyrsggplplt.....aadfwrlkelgiktivdLrseeErgrlkcdryw............pgirylhlpilddsaptilygal

-----------------------------------------------EDLVDLIERLLNllslDNKVYLHCWAGRGRTGIIGACLLGRlYQVT-------
                                               | |..|.| ||.    ...|. ||.||..|||.. |.||   ..|.       
rvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivdd

-------GLEALRRTQDCYQQRIIG
        .||... .... . .  
Ylltnlyleeaveelraqrpgavqt
0036282 (Phosphotyrosine protein) phosphatases II 80-227 5e-17 57.6 In-house 12-149 (174) alignment 
Range on Protein: 80-227
Range on HMM: 12-149/174.0
NWIVKDSILCGEYPGNkdddivhfkTLSTLLDSGIRVFVCLQEQDELKKFRPYREDILklsKEKGIDVDSVTFVHFPIEDGGIAENNEdLVDLIERLLNL
 ... . ...| .| .          .  | . ||.. |.| |  ||.... ..       . .      ......|..|.|  . .. | ...... . 
lsyitprliagqgpla.........fwemlkelgittvvmlleekelglykcinywpe...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveea

LSL--DNKVYLHCWAGRGRTGIIGACLLGRLYQV-TGLEALRRTQDCYQQR
||   ...|. || ||.||||.. |..|   ..  .  .||.  . . .||
lsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqr
0042113 (Phosphotyrosine protein) phosphatases II 79-223 6.5e-17 57.2 In-house 42-221 (245) alignment 
Range on Protein: 79-223
Range on HMM: 42-221/245.0
TNWI----VKDSILCGEYPGNKdddivhfkTLS----TLLDSGIRVFVCLQEQDELKK---------------------------FRPYREDILKLSK-E
 ...    ... .... .| ..        |.      | . ||.. |.| | .||..                           .  |   .|....  
asyvdgyritpkfiatqgPlpe........tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlg

KGIDVDSVTFVHFPIEDGGIAENNEDLVDLIERLLNLLS--LDNKVYLHCWAGRGRTGIIGACLLG-----RLYQVTGLEALRRTQDC
..     ... ..|..|.|.... |.|.|..|.... |.   ...|. || ||.|||| . |..|      ... |.  ||... ...
ddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsq
0048179 (Phosphotyrosine protein) phosphatases II 99-226 9.3e-17 56.6 In-house 15-126 (144) alignment 
Range on Protein: 99-226
Range on HMM: 15-126/144.0
DIVHFKTLSTLLDSGIRVFVCLQEQDELKKFRPYredilklskekgidvdSVTFVHFPIEDGGIAENNEDLVDLIERLLNLLSLDNKVYLHCWAGRGRTG
.. . . | .| . ||.  ..|.|. |   . ..                 ....|.|..| |. .  |.| ...| . ..|. ...|. ||.||.||||
slptaldlellkklgittvinlteeyepeflere................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtg

IIGACLLGRLYQVTGLEALRRTQDCYQQ
 . |. | ......  |||.. . .. .
tlvaaylmkklglsleealalvrsrrpg
0049772 (Phosphotyrosine protein) phosphatases II 92-228 2.5e-16 55.8 In-house 155-263 (314) alignment 
Range on Protein: 92-228
Range on HMM: 155-263/314.0
YpgnkddDIVHFKTLSTLLdsgirvfvclQEQDELKKFrpyredilklskekgidVD-SVTFVHFPIEDgGIAENNEDLVDLIERLLNLlSLDNKVYLHC
.      .. ....| .|           .|... ..|                  .  ......|..| | |   ||. ...| .... . ...|. ||
g......neptaadlellk..........eelydpelf.................erlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHC

WAGRGRTGI-IGACLLGRLYQVTGLEALRRTQDCYQ-----QRI
.||.||||  . |..| .|..|.  |||.. . ..        |
kaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfi
0041856 (Phosphotyrosine protein) phosphatases II 70-228 4.6e-16 54.4 In-house 17-154 (182) alignment 
Range on Protein: 70-228
Range on HMM: 17-154/182.0
DdmkgpldtTNWIVKDSILCGEYPG--------NKDDDIVHFktLSTLLDSGIRVFVCLQeqdelkkFRPYREdilklskeKGIDVDSVTFVHFPIEDGG
          .. . .... | .|.        . .... .|  | .| . ||.. |.|         ..|          .      ......|..|.|
r........dldyInanlylgslpatrfiatqgpllstvadf..lrmlkelgittivnlt.......eelywp........ellerlgiqylylpwpDhg

IAEnNEDLVDLIERLLNllsLDNKVYLHCWAGRGRTGIIGACLLGRLYQVTGLEALRRTQDCYQQRI
. .  ..|.|.||. |.    ...|. || ||.|||| . |. | . ..|.  ||..  . .  . .
vpd.ldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmv
0037934 (Phosphotyrosine protein) phosphatases II 39-226 9.7e-16 53.5 In-house 9-222 (243) alignment 
Range on Protein: 39-226
Range on HMM: 9-222/243.0
ENNNTNRNGNGITTPGSITFNtsgmycnddSDDMKGPLDTTNWIvkDSILCGEYPGNKDDDIVHFKTLSTLLDSGIRVFVCLQEQDELKKFRPYRE----
|| . ||  . .. . |  .          ...   ... ..    . . .. .| ..  . .. . .  | . ||.| |.| | .||...  ..     
enlsknrysdilpydhsrvkl.........egsdyinanliyvt..prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpge

---------------------DILKLSK--EKGIDVDSVTFVHFPIEDGGIAENNEDLVDLIERLLNL---------LSLDNKVYLHCWAGRGRTGIIGA
                       |.|.   ...     . . ..|. |.|. .. |||.|... . .          |. ...|..|| ||.|||| . |
vtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

CLLGRLY-QVTGLEALRRTQDCYQQ
..|  |. .|. .||... ...  .
aylmllllgvdleeavkllreqRpg
0048076 (Phosphotyrosine protein) phosphatases II 101-226 1.2e-15 52.9 In-house 17-124 (145) alignment 
Range on Protein: 101-226
Range on HMM: 17-124/145.0
VHFKTLSTLLDSGIRVFVCLqeqdelkkfrpyredilkLSKEKGIDVDSVTFVHFPIEDGGIAENNEDLVDLIERLLNLLSLDNKVYLHCWAGRGRTGII
 . . | .| | ||.  ..|                   | ...     ......|..| |. .  |.| ...| . ..|. ...|. ||.||.|||| .
ptaldlellkdlgittvlnl..................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtl

GACLLGRLYQVTGLEALRRTQDCYQQ
 |. | .|..|.  |||.. . .. .
vaaylmlllgvsleealelvrsqrpg
0051082 (Phosphotyrosine protein) phosphatases II 82-223 1.4e-15 52.7 In-house 10-131 (151) alignment 
Range on Protein: 82-223
Range on HMM: 10-131/151.0
IVKDSILCGEYPGNkdddivhfKTLSTLLDSGIRVFVCLQEQDELKKFRPYREDILklskekgidvdsVTFVHFPIEDGGIAENNEDLVDLIERLLNLLS
 | . .... .| .          | .| . ||.. |.| . .| ...  | ..              ....|.||.|       . .  ..| |  ||.
yvtgglyrsggpla........dflellkelgiktivnlrseeergycpeylpelg............ievlhipildwpdpglplsfdavleflellld

L-DNKVYLHCWAGRGRTGIIGACLLGRlYQVTGLEALRRTQDC
  ...|. ||.||.||||.. |..|   ..|.  |||.  . .
kkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlk
0044763 (Phosphotyrosine protein) phosphatases II 80-223 2e-15 52.3 In-house 24-150 (178) alignment 
Range on Protein: 80-223
Range on HMM: 24-150/178.0
NWIVKDSILCGEYPgnkdddivhFKTLSTLLDSGIRVFVCLQEQDELKKFRPYREDILKLSkekgidvdsVTFVHFPIEDGGIAENNEDLVDLIERLLNL
..|. . .|.. .|          . |  | . ||.. |.| | .|| ..  ....  . .         ....|.||.|.|  .  | . ...| . ..
seilpglylgslpp.........addlellkelgithivnlteelelgflkcdpywpeeag.........iqylhipipDhgvpdllehflefvefieea

L-SLDNKVYLHCWAGRGRTGIIGACLLGRLYQVTGLEALRRTQDC
| . ...|. || ||.||.| . |. | . ....  ||... . .
ldekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrer
0043147 (Phosphotyrosine protein) phosphatases II 71-222 6.1e-15 50.8 In-house 6-138 (172) alignment 
Range on Protein: 71-222
Range on HMM: 6-138/172.0
DMKGPLDTTNWIVKDSILCGEYPGNKDDDIVhfktLSTLLDSGIRVFVCLQEQdelkkfrpyredilkLSKEKGIDVDSVTFVHFPIEDGGIAeNNEDLV
|.    .   ... |..... .|.. ... .    .  | . ||.. |.| |                |   ..     ... ..|..|.|   . | | 
dyinasyldlyyipdrfiatqgplrntladf....wrmlkelgithivnltel...............lydpellerlgiqylylpwpDhgvp.llelll

DLIERLLN--LLSLDNKVYLHCWAGRGRTGIIGACLLGRlYQVTGLEALRRTQD
...| . .  .|| ...|. || || |||| . |..| . .... .||..  ..
eflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvre
0045098 (Phosphotyrosine protein) phosphatases II 85-222 6.8e-15 50.7 In-house 23-248 (278) alignment 
Range on Protein: 85-222
Range on HMM: 23-248/278.0
DSILCGEYPGNKDDDIV-------------------------------------HFKTLSTLLDSGIRVFVCLQEQDELKKFR---PYRE----------
..|... |.||.| .                                       . . . .| . ||.| |.| |  ||..     .. |          
seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdft

--------------DILKLSK----EKGIDVDSVTFVHF-PIEDGGIAENN--EDLVDLIERLLNLLS--------------LDNKVYLHCWAGRGRTGI
                |..      ....    || .|. |..|.|. ...    . .|.|.... |.               ...|. || || |||| 
vtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGt

IGACLLGRLY---QVTGLEALRRTQD
. |. | . .   .|. |||..  . 
lvaaylmlelleggvdlleavkelrs
0040439 (Phosphotyrosine protein) phosphatases II 83-223 9.1e-15 50.4 In-house 52-224 (249) alignment 
Range on Protein: 83-223
Range on HMM: 52-224/249.0
VKDSILCGEYPGNKdddiVHFKTLSTLLDSGIRVFVCLQEQDELK---------------------------KFRPYREDILKLSKEKGIDVDSVTFVHF
.|. ...  .| ..       . .  | . ||.| |.| . .||.                           ..  |    |.|.. .  ..  |. ...
ikrrfiatqgPlpe....tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqy

-PIEDGGIAENNEDLVDLIERLLNLLS---LDNKVYLHCWAGRGRTGIIGACLLG-----RLYQVTGLEALRRTQDC
 .. | |. .. |||.|.||.... |.    ...|. || || ||||.. |..|      . ..|. .||..  ...
tdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsq
0045450 (Phosphotyrosine protein) phosphatases II 80-223 1.4e-14 50.0 In-house 90-282 (307) alignment 
Range on Protein: 80-223
Range on HMM: 90-282/307.0
NWI------------VKDSILCGEYPGNKddDIVHFktLSTLLDSGIRVFVCLQEQDELKK------------FRPYREDILKLSKEKGidVDSVTFVHF
...            .|. ...  .| ..   . .|  .  | . |..| |.| | .||..            .  |...  .| .|.    |..|  ..
syvrvpllllldgydlkrkfIatqgPlpe..tvedF..wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh..ldgytvrtl

PIE--------------------DGGIAENNEDLVDLIERLLNLLS---LDNKVYLHCWAGRGRTGIIGACLLGRLYQ--------VTGLEALRRTQDC
...                    |.|. .. |.|.|.||.... |.    ...|. || || |||| . |..|   .         |. |||... ...
evtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreq
0049260 (Phosphotyrosine protein) phosphatases II 106-223 5.1e-14 47.7 In-house 26-128 (152) alignment 
Range on Protein: 106-223
Range on HMM: 26-128/152.0
LSTLLDSGIRVFVCLQEQDELKKFRPYREDilklskekgidvdsvTFVHFPIEDGGIAENNEDLVDLIERLLN-LLSLDNKVYLHCWAGRGRTGIIGACL
.  | . ||.. |.| | .||.|.  ..                 .. |.|..|.|  .. . | .|.. .   .|. ...|. || || |||| . |..
wrmlkelgittivmltellelgklkceqyi...............qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

LGRlYQVTGLEALRRTQDC
| . ..|. .||... . .
lml.lgvsleeavalvrek
0039614 (Phosphotyrosine protein) phosphatases II 81-223 2.7e-13 45.5 In-house 97-267 (297) alignment 
Range on Protein: 81-223
Range on HMM: 97-267/297.0
WIVKDSILCGEYPgnKDDDIVHFktLSTLLDSGIRVFVCLQEQDELKK-------------------------FRPYREDILKLSKeKGIDVDSVTFVHF
..... ...  .|   .. . .|  .  . . |..| |.| . .||..                            |    |.... .|       | ..
dlltrkfIatqgP..lpetvedF..wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqyt

PIEDGGIAENNEDLVDLIERLLNLLS---LDNKVYLHCWAGRGRTGIIGACLLG-----RLYQVTGLEALRRTQDC
.. |.|. .. |.| ...| . . |.    ...|. || || |||| . |..|      . ..|. |||... . .
gwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreq
PTEN_1 148-238 4.1e-13 44.6 In-house 93-178 (196) alignment 
Range on Protein: 148-238
Range on HMM: 93-178/196.0
DSVTFVHFPIEDGGIAENNEdLVDLIERLLNLLSL---DNKVYLHCWAGRGRTGIIGACLLGRLYQVTGLEALRRTQDCYQQRIIGygespeyH
  |.. |||||| |    .| | | .... . |..    |.|. || ||.||.| . |..| .... |  |||.. ...  .. .         
sgveylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapn.......s
0043336 (Phosphotyrosine protein) phosphatases II 102-223 3.1e-12 42.0 In-house 103-255 (278) alignment 
Range on Protein: 102-223
Range on HMM: 103-255/278.0
HFktLSTLLDSGIRVFVCLQEQDELKK--------------------------FRPYREDILKLSKEKGID-VDSVTFVHFPIEDGGIAENNEDLVDLIE
.|     . . |... |.| | .||..                          .  |    |.... .       . . .... |.|. |. ..|.|...
dF..wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

RLLNLLS-LDNKVYLHCWAGRGRTGIIGACLLG-----RLYQVTGLEALRRTQDC
.... |.  ...|. || || |||| . |..|      . . |. .||... . .
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreq
0047943 (Phosphotyrosine protein) phosphatases II 108-223 3.1e-12 42.0 In-house 96-250 (273) alignment 
Range on Protein: 108-223
Range on HMM: 96-250/273.0
TLLDSGIRVFVCLQEQDELKK------FRPYRED------------------------ILKLSKEKGIDVDSVTFVHFP-IEDGGIAENNEDLVDLIERL
 . . ..|| |.| | .||..      . .  ..                         |.|.. .  ..  || .|.. . | |. .. |.|...|| .
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

LNLLS---LDNKVYLHCWAGRGRTGIIGACLLG-----RLYQVTGLEALRRTQDC
 . |.    ...|. ||.|| |||| . |..|      . ..|. |||... ...
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsq
0038934 (Phosphotyrosine protein) phosphatases II 150-228 1.4e-11 39.9 In-house 80-160 (194) alignment 
Range on Protein: 150-228
Range on HMM: 80-160/194.0
VTFVHFPIEDGGIAENNEDLVDLIERLLNLLSL--DNKVYLHCWAGRGRTGIIGACLLGRLYQVTGLEALRRTQDCYQQRI
......|..| | . ..| | . .. .   |.   ...|. || ||.||||.. |. |   .. .  ||... ... .  |
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai
0040438 (Phosphotyrosine protein) phosphatases II 107-222 1.6e-11 39.5 In-house 104-253 (317) alignment 
Range on Protein: 107-222
Range on HMM: 104-253/317.0
STLLDSGIRVFVCLQEQDELK---------------------------KFRPYREDILKLSKEKGIDVDSVTFVHFPI-EDGGIAENNEDLVDLIERLLN
  . . |..| |.| | .||.                           .   .    |.... .. ..  ||  |..   |.|. .. ..|.|..|.. .
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

LLSL-DNKVYLHCWAGRGRTGIIGACLLG-----RLYQVTGLEALRRTQD
 |.  ...|  || || |||| . |..|      . ..|.  ||... . 
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelre
subfamily_PTPDC1_pd Subfamily PTPDC1 80-218 4.6e-11 37.5 In-house 16-149 (182) alignment 
Range on Protein: 80-218
Range on HMM: 16-149/182.0
NWIVKDsILCGEYPgnKDDDIVHFKTLSTLLDSGIRVFVCLQEQDELKKFR-PYREDILKLSKEKgIDVDSVTFVHFPIEDGGIAEnNEDLVDLIERLLN
.|...| ||    |  . . | ..| |  . .|||.. . |||. |  .   . .|.    ..|. .    ...  |...| | |   | ..|..  .  
tWvted.ilalarp..sqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlea.lmeqgiyvynfgwkDygvas.leriLdivkvvaf

LLSLDnKVYLHCWAGRGRTGIIGACLLGRLYQVTGLEALR
 |. . || .|| ||.||||.. || |    ..|. .|..
alqeg.kvavhChaGlGrtGvliacylvyakrltaekaik
subfamily_CDKN3_pd Subfamily CDKN3 90-209 5.7e-11 36.4 In-house 45-158 (202) alignment 
Range on Protein: 90-209
Range on HMM: 45-158/202.0
GEYPGNKDDDIVH--FKTLSTLLDSGIRVFVCLQEQDELKKFRPyrEDILKLSKEKGIDVDsvtfvHFPIEDGGIAENNeDLVDLIERLLNLLSLDNKVY
   || | ||.     | .  |   |..    |  . ||.|.|   . .|.| .. |. |      |.|| ||.. .   . ....| |   |   .|  
salpgckfddvrrsvekdieelksqgvedvfvlctrgelskyrv..rrlldlyqqaglivh.....hypiadglvpdia.sclkileelrinlkayrktl

LHCWAGRGRTGIIGACLLGRLY
.||. | ||. .. ||||  | 
vhcygglgrsslviaclllyld
subfamily_PTPMT1_pd Subfamily PTPMT1 85-223 1.1e-10 36.2 In-house 25-147 (171) alignment 
Range on Protein: 85-223
Range on HMM: 25-147/171.0
DSILCGEYPgnkdddivhFKTLSTLL--DSGIRVFVCLQEQDELKKFRPYREDILKLskekgidvdSVTFVHFPIEDGGIAENNEDLVDLIERLLNLLSL
| .. |  |         |. | . |  .  ..  |.|.|. ||| .    |.  ||          |....... |   | . |.| . .| . .  |.
dtvilGalP.........frslikeLiekenvkavvslneeyelkalansteewkkl.........gveqlqlatvDfteapdleklekgvefiekvask

DNKVYLHCWAGRGRTGIIGACLLGRLYQVTGLEALRRTQDC
 ..||.|| |||||.. . || |   ....  |||.  ...
gkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkk
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 104-208 2.3e-10 31.8 Pfam-A 62-158 (168) alignment 
Range on Protein: 104-208
Range on HMM: 62-158/168.0
KTLSTLLDSGIRVFVCLQEQDELKKFRpyREDILKLSKEKGIdvdsVTFvHFPIEDGGIAENnEDLVDLIERLLNLLSLDNKVYLHCWAGRGRTGIIGAC
|    |   ||.  . .  . || |.|    ..| | .. ||    ||  | || |||  .     ....| |   |    |  .||. | ||. .. ||
kdteelksygiqdvfvfctrgelskyr..vpnlldlyqqygi....vth.hhpiadggtpdi.ascleimeelatclknyrktlihcygglgrsclvaac

LLGRL
||  |
lllyl
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 104-208 2.3e-10 31.8 In-house 62-158 (168) alignment 
Range on Protein: 104-208
Range on HMM: 62-158/168.0
KTLSTLLDSGIRVFVCLQEQDELKKFRpyREDILKLSKEKGIdvdsVTFvHFPIEDGGIAENnEDLVDLIERLLNLLSLDNKVYLHCWAGRGRTGIIGAC
|    |   ||.  . .  . || |.|    ..| | .. ||    ||  | || |||  .     ....| |   |    |  .||. | ||. .. ||
kdteelksygiqdvfvfctrgelskyr..vpnlldlyqqygi....vth.hhpiadggtpdi.ascleimeelatclknyrktlihcygglgrsclvaac

LLGRL
||  |
lllyl
0046845 (Phosphotyrosine protein) phosphatases II 109-221 3.8e-10 35.1 In-house 97-250 (284) alignment 
Range on Protein: 109-221
Range on HMM: 97-250/284.0
LLDSGIRVFVCLQEQDELK--KFRPYREDI--------------------------LKLSKE--KGIDVDSVTFVHFPIEDGGIAENNEDLVDLIERLLN
... ..|| |.| | .| .  |. .|. ..                          |.|...  .|  .    | .... | |. .. |||..... . .
vweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

LLSL---DNKVYLHCWAGRGRTGIIGACLLGRLY--------QVTGLEALRRTQ
||.    ....  ||.|| |||| . |. |   .         |. |||..|  
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlr
0036941 (Phosphotyrosine protein) phosphatases II 109-219 5.8e-10 34.4 In-house 98-251 (297) alignment 
Range on Protein: 109-219
Range on HMM: 98-251/297.0
LLDSGIRVFVCLQEQDELKK-------------------------------FRPYREDILKLSKEKGIDVDSVTFVHFP-IEDGGIAENNEDLVDLIERL
... ...| |.| | .|| .                               .  |    |.... .. ..  ||  |.. . | |. |. ..|.|.||..
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

LNLLS---LDNKVYLHCWAGRGRTGIIGACLLG--------RLYQVTGLEALRR
.. |.    ...|. || || ||.| . |. |         . ..|. |||.. 
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkk
0050432 (Phosphotyrosine protein) phosphatases II 111-220 1.6e-09 33.0 In-house 130-274 (308) alignment 
Range on Protein: 111-220
Range on HMM: 130-274/308.0
DSGIRVFVCLQEQDELK--------------KFRPYRED----------------ILKLSKEKGIDVDSVTFVHFPI-EDGGIAENNEDLVDLIERLLNL
. ..|| |.| . .| .              ... |                    |.|.. .. ..  ||  |..  .|.|. .. |.|.|..|.. . 
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

LsLDNKVYLHCWAGRGRTGIIGACLLG-----RLYQVTGLEALRRT
|  ..... || || |||| . |..|      . . |. .||... 
l.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkkl
0051299 (Phosphotyrosine protein) phosphatases II 110-219 7e-09 31.0 In-house 113-260 (288) alignment 
Range on Protein: 110-219
Range on HMM: 113-260/288.0
LDSGIRVFVCLQEQDELKK---------------------------FRPYREDILKLSKE--KGIDVDSVTFVHF---PIEDGGIAENNEDLVDLIERLL
 . ..|| |.| . .||..                           .  |    |....    . |  | |  ||    . | |. .. |.|.|..... 
weqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvr

NLLS-LDNKVYLHCWAGRGRTGIIGACLLG-----RLYQVTGLEALRR
. |.  .. |. ||.|| |||| . |..|      . . |. |||..|
kalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkr
0048567 (Phosphotyrosine protein) phosphatases II 150-242 2.4e-08 28.5 In-house 39-136 (157) alignment 
Range on Protein: 150-242
Range on HMM: 39-136/157.0
VTFVHFPIEDGgiAENNEDLVDLIERLLNLLS----LDNKVYLHCWAGR---GRTGIIGACLLGRLYQVTGLEALRRTQDCYQQRIIGYGESPEYHPQKM
. ...|  ..|    |   |...| .| ..|.     ......|| ||.   |||. . .| |   .. |  ||..  . ...  ....  |  .. ...
lvyedfffdfG..PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynl
subfamily_PTEN_pd Subfamily PTEN 152-214 3.8e-06 22.0 In-house 82-145 (184) alignment 
Range on Protein: 152-214
Range on HMM: 82-145/184.0
FVHFPIEDGgIAENNEDLVDLIERLLNLLSLDNK--VYLHCWAGRGRTGIIGACLLGRLYQVTGL
  ..|..|   . . | | ...| . . |. |.|  | .|| ||.||||.. ...|    ...  
vavypfdDh.nppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllksllleka