Gene DDB_G0271350 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP005_AA protein Get Run
DdisP005_AA_1-145 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP19_pd Subfamily DSP19 7-141 5e-33 108.6 In-house 15-150 (152) alignment 
Range on Protein: 7-141
Range on HMM: 15-150/152.0
LDNFLYLGAAKDTKDEKEMEKLKITHIFSCA-GTVHS-PEKYIIANEKFEDDETVDISEQIEKAYWFIERVRMKKgARVFIHCMAGKSRSASIVLSYLLK
. . ||||.   ..|...... |||||.. | |...  |... . . .  |..  |.......|  ||| .| |.  .|..|| || |||||.|..||.|
veprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskd.gavlvHCnAGvSRsasvviaylmk

RDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKL
.   ||...| .....|  |.||.||..||...| .|
keelsleealelvrearpcikPneGFikqLkeyeael
PTPc_motif_SM00404 3-138 2.7e-31 103.3 In-house 2-138 (140) alignment 
Range on Protein: 3-138
Range on HMM: 2-138/140.0
ISMILDNfLYLGAAKDTKDEKEMEKLKITHIFSCAGTVHS----PEKYIIANEkFEDDETVDISEQIEKAYWFIERVrMKKGARVFIHCMAGKSRSASIV
.| ||.. |||| ... .... ..||.|||..... .|      ... |.  .  .|.|. ..|....|.. |||..  ||| .|..||.|| ||||...
psrilph.lylgskskaqnpallkklgithvinvteevsltkensgfqilqip.lddnekdklskyldkvldfiena.ekkggkvlVHCqaGvSRSatli

LSYLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLE
. ||....  ||.... .....|  |.|| .|..||...|
iaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_DSP1_pd Subfamily DSP1 7-144 2.1e-30 99.9 In-house 21-159 (163) alignment 
Range on Protein: 7-144
Range on HMM: 21-159/163.0
LDNFLYLGAAKDTKDEKEMEKLKITHIFSCAGTV--HSPEKYIIANEKFEDDETVDISEQIEKAYWFIERVRMKKGaRVFIHCMAGKSRSASIVLSYLLK
. .|||||..... . . ...|.||.|  .....  . .. .   . | || .. |||. .|..  ||..|. |.| .|.||| || |||....| ||.|
ildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknG.kvlihCqaGisRsstlclaylmk

RDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTNK
..  ||..   . ...|  |.|| ||..|| . | ||...
tkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
0044763 (Phosphotyrosine protein) phosphatases II 3-144 1.4e-29 98.4 In-house 23-173 (178) alignment 
Range on Protein: 3-144
Range on HMM: 23-173/178.0
ISMILDNfLYLGAAKDTKDEKEMEKLKITHIFSCAGTVHSP----EKYIIAN-------EKFEDDETVDISEQIEKAYWFIERVRMKKGARVFIHCMAGK
.|.||.. ||||.. . .| . . .|.|||| ....... .     .|   .         ..|. . |..|...... |||... .|| .|..||.||.
aseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGv

SRSASIVLSYLLKRDIHSLSDCLFYLHSKRLeIRPNDGFMNQLCDLELKLTNK
.||...|. ||.|.   || ... .....|  | ||.|...||...||.| ..
gRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
DSPc Dual specificity phosphatase, catalytic domain 11-138 1.1e-28 94.8 Pfam-A 1-131 (133) alignment 
Range on Protein: 11-138
Range on HMM: 1-131/133.0
LYLGAAKDTKdEKEMEKLKITHIFSCAGTVHS-----PEKYIIANEKFEDDETVDISEQIEKAYWFIERVrMKKGARVFIHCMAGKSRSASIVLSYLLKR
||||.... . .. .|||.||...... .|.      ....   . . ||... .||...|.|. |||.. ..|| .|..||.|| ||||.... ||.|.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmkt

DIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLE
.  ||.... .. ..|  |.||.||. ||...|
knlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 11-138 1.1e-28 94.8 In-house 1-131 (133) alignment 
Range on Protein: 11-138
Range on HMM: 1-131/133.0
LYLGAAKDTKdEKEMEKLKITHIFSCAGTVHS-----PEKYIIANEKFEDDETVDISEQIEKAYWFIERVrMKKGARVFIHCMAGKSRSASIVLSYLLKR
||||.... . .. .|||.||...... .|.      ....   . . ||... .||...|.|. |||.. ..|| .|..||.|| ||||.... ||.|.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatliiaYlmkt

DIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLE
.  ||.... .. ..|  |.||.||. ||...|
knlslneAyefvkerrskispnagflrqLleye
subfamily_DSP14_pd Subfamily DSP14 8-147 1.8e-28 93.5 In-house 11-150 (157) alignment 
Range on Protein: 8-147
Range on HMM: 11-150/157.0
DNFLYLGaAKDTKDEKEMEKLKITHIFSCAGTVHSPEKYIIA--NEKFEDDETVDISEQIEKAYWFIERVRMKKGaRVFIHCMAGKSRSASIVLSYLLKR
 . |.|. .  ........| |||.|  ..  . ...   |.  . . ||........  ....  || |..|.| .. .||.|| |||||..| ||.| 
tpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkgg.ktlvhCvaGvSRSAslclaylmky

DIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTNKQTL
   || .   ...|.|  |||| || .|| |.| ||..|.. 
eklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssv
subfamily_DSP10_pd Subfamily DSP10 6-146 2.3e-28 93.1 In-house 17-158 (159) alignment 
Range on Protein: 6-146
Range on HMM: 17-158/159.0
ILdNFLYLGAAKDTKDEKEMEKLKITHIFSCAGTV---HSPEKYIIANEKFEDDETVDISEQIEKAYWFIERVRmKKGARVFIHCMAGKSRSASIVLSYL
.|  ||.||..|| .|.. ...|.||...  . .|   .. |.      . .| .. ..... |.|. ||| .| |||.||..||.|| ||||..|..||
vl.pfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieear.kkgsrvLvhCqaGisrsatvviaYl

LKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTNKQT
.|.   ||.|   . ..||  | || .|| || ..| .|.....
mkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnkska
subfamily_DSP12_pd Subfamily DSP12 9-135 1e-26 88.2 In-house 7-137 (155) alignment 
Range on Protein: 9-135
Range on HMM: 7-137/155.0
NFLYLGAAKDTKDEKEMEKLKITHIFSCAGT-V--HSPEKYIIA--NEKFEDDETVDISEQIEKAYWFIERVRmKKGARVFIHCMAGKSRSASIVLSYLL
. |||| ... ..|. ...|||||. | . . .  |...|  ..  . .  |....|| . ...|  |||  . ...  |..||.|| |||..||. ||.
pglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieeal.eeegavlvHCqagvSRSvtiviAYlm

KRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLC
|..  ||.. |  ...|. ||.||.||..|| 
kkeklslekAlklvkekkpeiepNegFleQLk
subfamily_DSP3_pd Subfamily DSP3 11-144 4.2e-26 85.5 In-house 18-160 (162) alignment 
Range on Protein: 11-144
Range on HMM: 18-160/162.0
LYLGAAKDTKDEKEMEKLKITHIFSCAGT----VHS-PEKYIIAN-----EKFEDDETVDISEQIEKAYWFIERVRMKKGARVFIHCMAGKSRSASIVLS
||.| ..  ||.....|| |||.. .| .    |.  .| |  ..      . .|  ..|.|.  |.|  ||..   .| ..|..||..| |||| .|| 
lyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvla

YLLKRDIHSLSDCLFYLHSKRlEIRPNDGFMNQLCDLELKLTNK
||. |   .| . .   ..|| ||.||.||..||..|. .|..|
yLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkrk
subfamily_MKPLT_pd Subfamily MKPLT 4-138 3e-25 82.7 In-house 22-157 (164) alignment 
Range on Protein: 4-138
Range on HMM: 22-157/164.0
SMILDNFLYLGAAKDTKDEKEMEKLKITHIFSCAGTVHS--PEKYIIANEKFEDDETVDISEQIEKAYWFIERVrMKKGARVFIHCMAGKSRSASIVLSY
|..|.. |||| ||....|| ...||||||   .   ..  |.     . | ||  .  .|. .|.|  |.    .. | ||..||  |||||.|. . .
svvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakflada.idsGGrvlvhcvqGksrsssvtvaf

LLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLE
|.|   . | .   ||  .|  ..|| ||. ||.  |
LikskgwtlkeayeylkerrsivapnrGflkqlakfe
subfamily_MKPLV_pd Subfamily MKPLV 4-138 3e-25 82.7 In-house 22-157 (164) alignment 
Range on Protein: 4-138
Range on HMM: 22-157/164.0
SMILDNFLYLGAAKDTKDEKEMEKLKITHIFSCAGTVHS--PEKYIIANEKFEDDETVDISEQIEKAYWFIERVrMKKGARVFIHCMAGKSRSASIVLSY
|..|.. |||| ||....|| ...||||||   .   ..  |.     . | ||  .  .|. .|.|  |.    .. | ||..||  |||||.|. . .
svvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakflada.idsGGrvlvhcvqGksrsssvtvaf

LLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLE
|.|   . | .   ||  .|  ..|| ||. ||.  |
LikskgwtlkeayeylkerrsivapnrGflkqlakfe
0048076 (Phosphotyrosine protein) phosphatases II 4-141 7e-25 82.8 In-house 5-142 (145) alignment 
Range on Protein: 4-141
Range on HMM: 5-142/145.0
SMILDNfLYLGAAKDTKDEKEMEKLKITHIFSCAGTVHSPEKYII--ANEKFEDDETVDISEQIEKAYWFIERVRMKKgARVFIHCMAGKSRSASIVLSY
|.||.. ||||   ...| .....|.||...... . . .|...|   .  ..| .. |..|...... |||... ..  .|..||.||..|....|. |
seilpg.lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaay

LLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKL
|...   || ..| ...|.|  . ||.|....|...||.|
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_DSP6_pd Subfamily DSP6 6-143 7.8e-25 81.2 In-house 17-156 (158) alignment 
Range on Protein: 6-143
Range on HMM: 17-156/158.0
ILdNFLYLGAAKDTKDEKEMEKLKITHIFSCAGT----VHSPEKYIIANEKFEDDETVDISEQIEKAYWFIERVRMKKgARVFIHCMAGKSRSASIVLSY
|| ..||||.|||... . ..|||| ...  .       .. ..    .   ||  . .... . .|  ||.  | || . |..||.|| |||  ..|.|
il.pllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskk.skvlvhClaGisrsvtvtlay

LLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTN
|.|.   || |   ...... .| ||  ||.|| | | .|. 
lmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
0048179 (Phosphotyrosine protein) phosphatases II 4-138 2.5e-24 81.0 In-house 5-141 (144) alignment 
Range on Protein: 4-138
Range on HMM: 5-141/144.0
SMILDNfLYLGAAKDTKDEKEMEKLKITHIFSCAGTvHSPEKY-----IIANEKFEDDETVDISEQIEKAYWFIERVRMkKGARVFIHCMAGKSRSASIV
|.||.. ||||   ...| ... ||.||...... . . || .      . .  ..| .. |..|...... |||...  .| .|..||.||..|....|
seilpg.lylgslptaldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlv

LSYLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLE
. ||.|.   || ..| ...|.|  . ||.|....|...|
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleye
subfamily_Slingshot_pd Subfamily Slingshot 9-144 1e-23 77.6 In-house 24-160 (169) alignment 
Range on Protein: 9-144
Range on HMM: 24-160/169.0
NFLYLGAAKDTKDEKEMEKLKITHIFSCAGTVHS--PEKYIIANEKFEDDETVDISEQIEKAYWFIERVRmKKGARVFIHCMAGKSRSASIVLSYLLKRD
...|||.  .. . .|... ....|.  .  ...  |||.   | .  |.|. |. .. ...| |||... |||..|..||  | |||||.|..| .|. 
dhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekak.kkgskvlvhckmGvsrsastviayamkey

IHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTNK
  || ..| |....|  |.||.||..||   |  |. .
glsleealeyvkerrsvikPnkgflkqleeyeGileas
subfamily_DSP8_pd Subfamily DSP8 5-145 1.3e-23 77.3 In-house 17-158 (159) alignment 
Range on Protein: 5-145
Range on HMM: 17-158/159.0
MILdNFLYLGAAKDTKDEKEMEKLKITHIFSCAGTvhSPEKYIIANEKF-----EDDETVDISEQIEKAYWFIERVRMKKGaRVFIHCMAGKSRSASIVL
 || ..||||. ||. .|. ..|| |...     .   |..  . ..||     .|. . .... ..|.. ||.... ..| ||..|..||.||||....
ril.knlylGsqkdvlseellsklgisyvlnasns..cpkleelkeskflrvPvkDkydekllpwfdksvefidkakseng.rvlvhvlaGisrsatvai

SYLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTNKQ
.|..|.   || ..  ....||  | ||  |..|| . | .|....
ayimktlemsldeayrfvkekrptispnlnflgqLleyekelkllt
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 4-138 1.8e-23 76.7 In-house 8-144 (148) alignment 
Range on Protein: 4-138
Range on HMM: 8-144/148.0
SMILDNFLYLGAAKDTKDEKEMEKLKITHIFSCAGTVHSP--EKYI-IANEKFEDDETVDISEQIEKAYWFIERVRmKKGARVFIHCMAGKSRSASIVLS
| | | ||.||. |   | . ...| .|.| ...   . .  .. |   . . .|..  |.|   |..  |..... ..| || .|.  | |||. ..| 
seikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkak.deGrrvLvhlqmGvsrssalall

YLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLE
.|.. .  || . | . .|||  ..|| ||..|| .||
wlidfkrvslkealalvkskrryvdpnlgfLkqLaele
subfamily_DSP15_pd Subfamily DSP15 3-143 2.8e-23 76.7 In-house 2-141 (151) alignment 
Range on Protein: 3-143
Range on HMM: 2-141/151.0
ISMILDNfLYLGAAKDTKDEKEMEKLKITHIFSCAGtvhsPEKYIIAN-----EKFEDDETVDISEQIEKAYWFIERVRMKkGARVFIHCMAGKSRSASI
|| .| . ||||  .|.|||. ... .|||| |        .| .. .      . .|   ...|. ....  || . |.| .  |..||.|| |||. .
iskvlpg.lylgnfrdskdeelLkeknithilsvhd....nakkllkdieYkciaasDtpsaklskffkesvefihkcRlk.eenvlvhClaGvsRsvtl

VLSYLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTN
|  ||.     .  |.|  .. .|    || || .|| . | . ..
vvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklk
subfamily_LRR-DSP_pd Subfamily LRR-DSP 6-142 2.4e-22 73.3 In-house 123-259 (263) alignment 
Range on Protein: 6-142
Range on HMM: 123-259/263.0
ILDNfLYLGAAKDTKDEKEMEKLKITHIFSCAGTVH----SPEKYIIANeKFEDDETVDISEQIEKAYWFIERVRMKKGarVFIHCMAGKSRSASIVLSY
|.|. |.||. . ....  ...| .|||. . . ..       ||.. . . || .  |||   |.   |||  | | |  |..|| || |||...|.||
iidk.lflGgldsannksilkdlgvthillavadfePlfPklfkylsid.diedvdeadisqhfeetnafieeGrkkGG..vlvhcraGvsrsstlvisy

LLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLT
|.|..   . . |    .|| .|.|| ||..||   | || 
lmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
0049772 (Phosphotyrosine protein) phosphatases II 52-148 3.3e-22 75.1 In-house 187-280 (314) alignment 
Range on Protein: 52-148
Range on HMM: 187-280/314.0
KFEDdETVDISEQIEKAYWFIERVrmKKGARVFIHCMAGKSRSAS-IVLSYLLKRDIHSLSDCLFYLHSKRLeIRPNDGFMNQLCDLELKLTNKQTLS
 ..| ......|...... |||..  .|| .|..||.|||.|... .|. ||.|.   || ..| ....||  |.||.||..||...| .|  .. . 
pvpD.gsaplledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealleyl
0041856 (Phosphotyrosine protein) phosphatases II 3-145 7.6e-22 73.2 In-house 19-176 (182) alignment 
Range on Protein: 3-145
Range on HMM: 19-176/182.0
ISMILDNfLYLGAAKD--------------TKDEKEMEKLKITHIFSCAGTVHSPEKY-----IIANEKFEDDETVDiseqIEKAYWFIERVRMkKGARV
...|..| ||||. ..               .. . . .|.||.| ....  . ||..      . .  ..|... |    ..... |||.|.  .| .|
ldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevle.eggpv

FIHCMAGKSRSASIVLSYLLKRDIHSLSDCLFYLHSKRL--EIRPNDGFMNQLCDLELKLTNKQ
..||.||..|....|. ||.|.   || ... .. |.|    |.|| .|. ||. |||.| .|.
lVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
0043147 (Phosphotyrosine protein) phosphatases II 10-140 2.4e-20 68.4 In-house 25-159 (172) alignment 
Range on Protein: 10-140
Range on HMM: 25-159/172.0
FLYLGAAKDTKDEKEMEKLKITHIFSCAGTVHSPEKYIIA-----NEKFEDDETVdISEQIEKAYWFIER-VRMKKGARVFIHCMAGKSRSASIVLSYLL
.....   . .. . . .|.||||... . .. ||..           ..|  .  ..|...... ||.. .  ..| .| .||.||..|.. .|. ||.
tqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm

KRDIhSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELK
.... || ... .. .||  . .|......|...| .
llgl.sleeavalvrekRpgavqnpsqyrflyyfekl
0036282 (Phosphotyrosine protein) phosphatases II 2-141 3.2e-20 68.0 In-house 11-169 (174) alignment 
Range on Protein: 2-141
Range on HMM: 11-169/174.0
GISMILDNFLYLGAAKDtkDEKEMEKLKITHIFSCAGTVHSP-----------------EKYIIANEKFEDDETVDISEqIEKAYWFIERVRMK-KGARV
..|.|.....  ..  .  . ... .|.||.....   ..                   . . .    ..|... |.|. ..... |.|... . .|  |
dlsyitprliagqgpla..fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpv

FIHCMAGKSRSASIVLSYLLKRDIH-SLSDCLFYLHSKR---LEIRPNDGFMNQLCDLELKL
 .||.||..|.. .|. ||..| .. || | | .....|     . ...... .| ..| .|
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
PTEN_1 8-142 8.5e-20 66.4 In-house 45-192 (196) alignment 
Range on Protein: 8-142
Range on HMM: 45-192/196.0
DNFLYLGAAKDT-KDEKEMEKLKITHIFSCAGTVH-----------SPEKYIIANEKFEDDETVDISEQIEKAYWFIERVRMKK-GARVFIHCMAGKSRS
| .||.| .||  .| ..... .||.... .   .             ....  .  .||. . ..|| .. .. ||| .. .. |  | .|| ||..||
deglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRs

ASIVLSYLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLT
. .| .||...   .  . | .. .||  ..|| .....|   . .| 
GtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 9-141 2.1e-19 63.4 In-house 8-152 (154) alignment 
Range on Protein: 9-141
Range on HMM: 8-152/154.0
NFLYLGAAKDTKDEKEMEKLKITHIFSC-AGTVHS-PE-------KYIIA--NEKFEDDETVDISEQIEKAYWFIERVR-MKKGARVFIHCMAGKSRSAS
 |||... . . .  .... .|..|. .  |.    ..        .||   | .. ||   || |...||. ||.      .  .|..|. .| ||||.
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

IVLSYLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKL
...|||...   ||| .|  |.. |  |.|| ||..||.  | .|
llisylmdklkislslalellkdsryiikPnqGflkqleifekel
0049260 (Phosphotyrosine protein) phosphatases II 9-138 5.2e-19 63.9 In-house 13-146 (152) alignment 
Range on Protein: 9-138
Range on HMM: 13-146/152.0
NFLYLGAAKDTKDEKEMEKLKITHIFSCAGTVH-----SPEKYIIANEKFEDDETVDISEQIEKAYWFIERVRMKKGARVFIHCMAGKSRSASIVLSYLL
 ....|     .. . . .|.||.| ..   .       .. . . .  ..|. . |.|. .. ...|||. . .|| .|..||.||..|.. .|. ||.
atqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

KrDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLE
.    || ... .. .||  . || |.. .| . |
l.lgvsleeavalvrekRpgavpnpgqlrflyefe
0046846 (Phosphotyrosine protein) phosphatases II 6-142 6.1e-19 63.9 In-house 15-173 (176) alignment 
Range on Protein: 6-142
Range on HMM: 15-173/176.0
ILDNfLYLGAAK----------DTKDEKEMEKLKITHIFSCAGTVHSPE-------------KYIIANEKFEDDETVDIsEQIEKAYWFIERVRMKKgAR
|..| |.||..             .. ... .|.||.....   |.                .. . .  ..|  . |. |...... ||.... ..  .
inan.lilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg.gp

VFIHCMAGKSRSASIVLSYLLKR-DIHSLSDCLFYLHSKRL-EIRPNDGFMNQLCDLELKLT
| .||.||..|.. .|. |||..    |. ..| .. ..|   . ...... .| . ||.| 
vlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 11-144 1.3e-17 57.2 In-house 6-144 (145) alignment 
Range on Protein: 11-144
Range on HMM: 6-144/145.0
LYLGAAKDTKDEKEMEKLKITHIFSCAGT--VHSPEK----YIIANEKFEDDETVDISEQIEKAYWFIERVRmKKGARVFIHCMAGKSRSASIVLSYLLK
|| |.|  ..|   ...| |. |   | .  | | |     . |     || |. |.|. ...   ||.. . ..|| ||.||||| ||| .. ...|.|
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgk.eegagvfvhcmagvsrsvtvsvaflmk

RDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTNK
    .||.    ..|.||   ||  |...| .|| .| ..
ycnmtlseaarqvrsnrllaypnvtflknllnlekqlkee
0040439 (Phosphotyrosine protein) phosphatases II 25-142 1.3e-17 59.7 In-house 74-246 (249) alignment 
Range on Protein: 25-142
Range on HMM: 74-246/249.0
MEKLKITHIFSCAGTV---------------------------------------------HSPEKYIIANEKFEDDETVDISEQIEKAYWFIERVRM--
. .|.||.| ..  .|                                               .|.. .    . |    .... .| .  |||.||   
lwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkal

---KKGARVFIHCMAGKSRSASIVLSYLL-----KRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLT
   .|| .|..||.||..|.. ... ||.     |.   .| ... .| |.|  . .|.... .|....|.| 
eelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 9-141 2.5e-17 58.6 In-house 52-242 (245) alignment 
Range on Protein: 9-141
Range on HMM: 52-242/245.0
NFLYLGAAKDTKDEK----EMEKLKITHIFSCAGTV------------------------------------------------HSPEKYIIANEKFEDD
. ......  ... .     . .|.||.|...  ..                                                 | | . .    ..|.
pkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdh

ETVDISEQIEKAYWFIERVRM-KKGARVFIHCMAGKSRSASIVLSYLL-----KRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKL
 . |..|...... |.....  ... .|..||.||..|.. ... ||.     |.   || ... .| |.|  ........ .| ...|.|
gvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0045098 (Phosphotyrosine protein) phosphatases II 8-142 2.9e-17 58.4 In-house 26-272 (278) alignment 
Range on Protein: 8-142
Range on HMM: 26-272/278.0
DNFLYLGAAK-----------------------------------------DTKDEKEMEKLKITHIFSCAGTVHS------------------------
 ..|||| ..                                           .. . . .|.||.| .... |.                         
tpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtl

----------------------------PEKYIIANEKFEDDETVDIS--EQIEKAYWFIERVRMK-------------KGARVFIHCMAGKSRSASIVL
                             . ...    ..| .. . .   .. ... ||.... .             .| .|..||.||..|.. .|.
lseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlva

SYLLKRD---IHSLSDCLFYLHSKRLE-IRPNDGFMNQLCDLELKLT
 ||...      .| ... .| |.|   . .| .....|....|.| 
aylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0045450 (Phosphotyrosine protein) phosphatases II 26-142 6.8e-17 57.6 In-house 128-304 (307) alignment 
Range on Protein: 26-142
Range on HMM: 128-304/307.0
EKLKITHIFSCAGTVHS------------------------------PEKYIIANEKFEDD-----------------ETVDISEQIEKAYWFIERVRM-
 ....|.| .. ..|                                 ..|.. . . .|                     .... .| .  |||.||  
weqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrka

----KKGARVFIHCMAGKSRSASIVLSYLLKRDI--------HSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLT
    .|| .| .||.||..|...... ||..| .         .| ... .| ..|  . .| ... .|....|.| 
leelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0051082 (Phosphotyrosine protein) phosphatases II 4-137 9.9e-17 56.4 In-house 9-149 (151) alignment 
Range on Protein: 4-137
Range on HMM: 9-149/151.0
SMILDNfLYLGAAKDTKDEKEMEKLKITHIFSCAGTVHSPeK---------YIIANEKFEDDETVDISEQIEKAYWFIERVRMKKGARVFIHCMAGKSRS
|.. .. ||....    . .....|.|..|... .... . .           . .  ..|. . .... .. .  |.| .. ||.  |..||.|||.|.
syvtgg.lyrsggpladflellkelgiktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

ASIVLSYLLKRDiHSLSDCLFYLHSKRL-EIRPNDGFMNQLCDL
. .|. ||....  || ..| ....||   ..||..|. ||..|
Gtlvalylmllg.vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_STYXL1_pd Subfamily STYXL1 6-142 7.5e-16 51.7 In-house 14-154 (157) alignment 
Range on Protein: 6-142
Range on HMM: 14-154/157.0
ILDNFLYLGAAKDTKDEKEMEKLKITHIFS---CAGTVHSPEKY--IIANEKFEDDETVDISEQIEKAYWFIERVRMkKGARVFIHCMAGKSRSASIVLS
.| ..||||  |......  . ||.         |. . .  .    . . . ||..  |. |....|  |||. .  .|  |..    | ||||.....
vlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkk.egevvlvfsnkGisrsaaviia

YLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLT
||.     .| ... ||.  .  ..|| .|..|| . | .| 
ylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
0039614 (Phosphotyrosine protein) phosphatases II 28-142 7.5e-16 53.9 In-house 124-289 (297) alignment 
Range on Protein: 28-142
Range on HMM: 124-289/297.0
LKITHIFSCAGTVH--------------SPEKYI------------------------------IANEKFEDDETVDISEQIEKAYWFIERVRMK--KGA
...|.| .   .|                 ...                               .   .. |. . ...|.. ... ...... .  || 
qgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkgg

RVFIHCMAGKSRSASIVLSYLL-----KRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLT
.| .||.||..|...... ||.     |.   .. ... .| ..|  ........ .|.|..|.| 
pvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0040438 (Phosphotyrosine protein) phosphatases II 25-157 1.2e-15 53.1 In-house 123-291 (317) alignment 
Range on Protein: 25-157
Range on HMM: 123-291/317.0
MEKLKITHIFSCaGTV--------------HsPEKYIIANEKFEDD----------------ETVDISEQIEKAYWFIERVRMK---KGARVFIHCMAGK
... |  . ..  |..              .  . ... . ..||.                   .. . ..    |.|.|| .   .|  | .||.||.
lgrekcaqYwpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGv

SRSASIVLSYLL-----KRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTNKQTLSKEIKEWRSL
.|...... ||.     |.   .. ... .| ..|  . .. ... .|.|..|.. ..   .....|. ..
gRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklk
0037934 (Phosphotyrosine protein) phosphatases II 5-141 2.1e-15 52.4 In-house 41-241 (243) alignment 
Range on Protein: 5-141
Range on HMM: 41-241/243.0
MILDNfLYLGAA--------KDTKDEKEMEKLKITHIFSCAGTV------------------------------------------HSPEKYIIA-----
..... |... .        .. .. . . .|.||.| ..  .|                                          ......        
yvtpr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

NEKFED----DETVDISEQIEKAYWFIERV----RMKKGARVFIHCMAGKSRSASIVLSYLLKR--DiHSLSDCLFYLHSKRLE-IRPNDGFMNQLCDLE
   . |    |.. |. . ..... |||..      ..| .| .||.||..|.. ... ||...  .  .| ... .| ..|   . .. ... .| ...
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg.vdleeavkllreqRpgkavqtpsqyrflyeal

LKL
|.|
lel
0036941 (Phosphotyrosine protein) phosphatases II 27-150 1.1e-14 49.9 In-house 117-285 (297) alignment 
Range on Protein: 27-150
Range on HMM: 117-285/297.0
KLKITHIFSCA-GTVHSPEKYIIANEKFED-------------------------------DETVDISEQIEKAYWFIERVRM-----KKGARVFIHCMA
. |  . ..   | .   ..... . ..|                                    .. | ..    |||.||       .| .| .||.|
rekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsa

GKSRSASIVLSYLL--------KRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTNKQTLSKE
|..||..... .|.        |.   .. ... .| ..|  . .. ... .|....|.| .|...  .
GvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkep
subfamily_PTPMT1_pd Subfamily PTPMT1 58-131 1.6e-14 48.7 In-house 81-158 (171) alignment 
Range on Protein: 58-131
Range on HMM: 81-158/171.0
TVDIS-----EQIEKAYWFIERVRmKKGARVFIHCMAGKSRSASIVLSYLLKRDIHSLSDCLFYLHSKRLEIRPNDGFM
|||.      |..||.  |||.|. .|| ||..|| ||..|||..| .||.|..  |. . | .|..||  || ..  .
tvDfteapdleklekgvefiekva.skgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqw
0043336 (Phosphotyrosine protein) phosphatases II 39-140 3.1e-13 45.3 In-house 169-275 (278) alignment 
Range on Protein: 39-140
Range on HMM: 169-275/278.0
TVHSPEKYIIANEKFEDDETV-DISEQIEKAYWFIERVRmKKGARVFIHCMAGKSRSASIVLSYLL-----KRDIHSLSDCLFYLHSKRLEIRPNDGFMN
.  | . ...   .. |...  ..|  ..   ...|... ...  | .||.||..|.. ... |||     |.   .| ... .| ..|  . ... .. 
dgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyr

QLCDLELK
.|....| 
flyealle
0051429 (Phosphotyrosine protein) phosphatases II 5-144 1.5e-12 43.3 In-house 18-227 (272) alignment 
Range on Protein: 5-144
Range on HMM: 18-227/272.0
MILDNFLYLGAAK---DTKDEKEMEKLKITHIFSCAGTV---HSP-EKYIiA-----NEKFEDDETVDIS------------------------------
......||....    . .| . ...|.|..|..  ...   . . ..|. .     .  ..||.. .|.                              
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw.pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

---------------------EQIEKAYWFIERvrmkkGARVFIHCMAGKSRSASIVLSYLLKRDIH-------------SLSDCLFYLHSKRLEIRPND
                     |.. ..  .. .     | .| .||.|||.|.. .|. .|| ....              | ... .| ..|  .....
gearevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqte

GFMNQLCDLELKLTNK
... .|.. .|.| ..
eqylflyeallellrs
0038934 (Phosphotyrosine protein) phosphatases II 53-137 1.5e-12 43.1 In-house 87-172 (194) alignment 
Range on Protein: 53-137
Range on HMM: 87-172/194.0
FEDDETVDISEQIEKAYWFIERVRMK-KGARVFIHCMAGKSRSASIVLSYLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDL
|.|| ||   |.. . . .....  . .|  | .||.||..|.. .| .||..|   |. ... .. .||  . || .....|.  
fpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr
subfamily_STYX_pd Subfamily STYX 55-141 2.4e-12 40.2 In-house 72-158 (166) alignment 
Range on Protein: 55-141
Range on HMM: 72-158/166.0
DDETVDISEQIEKAYWFIERVrMKKGARVFIHCMAGKSRSASIVLSYLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLEL-KL
|. . .|   . .   ||.   ..|| .|..|  || ||||..|..|...       ..  |.  .|. | ||.||..|| . |   |
dntveniirylptvkefidds.lqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyl
subfamily_MSG5_pd Subfamily MSG5 76-144 5.5e-11 35.9 In-house 95-163 (165) alignment 
Range on Protein: 76-144
Range on HMM: 95-163/165.0
RMKKGARVFIHCMAGKSRSASIVLSYLLKRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCDLELKLTNK
   |. ....||  | |||||....|..|    || |.   |.|.  .| |. |.. || . |  |..|
atskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk
0047943 (Phosphotyrosine protein) phosphatases II 52-136 1.4e-10 36.6 In-house 175-266 (273) alignment 
Range on Protein: 52-136
Range on HMM: 175-266/273.0
KFEDDETVDISEQIEKAYWFIERVRMK--KGARVFIHCMAGKSRSASIVLSYLL-----KRDIHSLSDCLFYLHSKRLEIRPNDGFMNQLCD
.. |. . .  |.. . ........ .  ..  | .||.||..|...... .||     |.   .. ... .| |.|  . ..  .. .|..
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 42-126 1.8e-08 29.7 In-house 181-270 (288) alignment 
Range on Protein: 42-126
Range on HMM: 181-270/288.0
SPEKYIIANEKFEDDETVDISEQIEKAYWFIERVRMKKGARVFIHCMAGKSRSASIVLSYLL-----KRDIHSLSDCLFYLHSKRLEIRP
| . ...   .. |. . |  |.. . . .. ... ..|  | .||.||..|.. ... .||     |.   .. . . .| ..|  . .
srtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvq
0050432 (Phosphotyrosine protein) phosphatases II 53-122 1.7e-07 26.4 In-house 175-279 (308) alignment 
Range on Protein: 53-122
Range on HMM: 175-279/308.0
F--------------------------------EDDETVDISEQIEKAYWFIERVRmkKGARVFIHCMAGKSRSASIVLSYLL-----KRDIHSLSDCLF
                                 .|. . .  |.. . ........  .|  . .||.|| .|.. ... .||     |    .. ... 
eevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavk

YLHSKRL
.| ..| 
klReqRp
0046845 (Phosphotyrosine protein) phosphatases II 62-121 1.2e-06 23.6 In-house 184-253 (284) alignment 
Range on Protein: 62-121
Range on HMM: 184-253/284.0
SEQIEKAYWFIERVRM--KKGARVFIHCMAGKSRSASIVLSYLLKRD--------IHSLSDCLFYLHSKR
.|.. . ........   ..|  . .||.||..|.. ... .||..           .. ... .| ..|
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR
subfamily_Laforin_pd Subfamily Laforin 76-121 3.2e-06 20.1 In-house 106-151 (183) alignment 
Range on Protein: 76-121
Range on HMM: 106-151/183.0
RMKKGARVFIHCMAGKSRSASIVLSYLLKRDIHSLSDCLFYLHSKR
 ..|| .|..|| ||  ||..||  .|      ||.   ..| .||
llekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr
PTPc_DSPc_SM00012 63-111 5.2e-06 22.0 In-house 20-70 (105) alignment 
Range on Protein: 63-111
Range on HMM: 20-70/105.0
EQIEKAYWFIERVRMKK--GARVFIHCMAGKSRSASIVLSYLLKRDIHSLS
. | .. . ..... |.  .. | .|| || .|.. .|. ..| ..... .
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket