Gene DDB_G0271860 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP008_AA protein Get Run
DdisP008_AA_344-475 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP1_pd Subfamily DSP1 320-481 5.8e-84 274.1 In-house 1-159 (163) alignment 
Range on Protein: 320-481
Range on HMM: 1-159/163.0
SSRWLGCDLDKLKTYDPICsKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnpMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGK
|||||||||||||.|||.. |..|.||.||||||||||||||.|||.|.|.|...||.|.|  .|||.||.|.||| .|||||||.|||||......|||
ssrwlgcdldklklydPve.kildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGk

IFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWAIKEGIQ
..||||.|.||||.||....|||.|.|||||.|.|||.|.|..|||||.|.|||...|.. .
vlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
0044763 (Phosphotyrosine protein) phosphatases II 334-475 8.9e-38 125.1 In-house 19-167 (178) alignment 
Range on Protein: 334-475
Range on HMM: 19-167/178.0
YDPICSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNPM-------FEYRKLHLRDSPLEDISLVFEQVIEFIERAI-ACNGKIFIHCQ
. . .|.....||.||   |..|| || .|||||.| .. . ..|....        ..|..... |..  |..  |....||||.|.  ..|....||.
dyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCs

MGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPiSRPNAGFQLSLLNWA
.||.|| .|.....||. ..||||| .||...||   || |..  |. ..
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefe
PTPc_motif_SM00404 338-475 1.7e-37 123.4 In-house 2-138 (140) alignment 
Range on Protein: 338-475
Range on HMM: 2-138/140.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFfQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
.|.....||.||.. |.|...||..||||.||.. ....  . |. |.. .. |.|.  ...|  ...|..|||.|.. .||...|||.||||| .|.. 
psrilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
..|..  .||.|| ..||. ||| .||..|  .|... 
YlmryrqlslaeayefvkerRpiispnlnfvrqLieye
subfamily_DSP19_pd Subfamily DSP19 338-474 9.3e-37 120.7 In-house 12-146 (152) alignment 
Range on Protein: 338-474
Range on HMM: 12-146/152.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNpmFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
 ..|...||.||  ||.. ||||...||||.| . . .|.| ..  |.| .... | | .|.. .......||| |   .| ...||. |||||. . . 
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkd..ftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvvia

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..||... ||||| .||...||  .||.||.  | ..
ylmkkeelsleealelvrearpcikPneGFikqLkey
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 343-474 1.2e-35 116.2 In-house 13-143 (148) alignment 
Range on Protein: 343-474
Range on HMM: 13-143/148.0
DYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNpMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKT
 .|..||   |..|| ||  |.|.|.||....|| ...    || .. |.| | ||.| .||..|.|...| .  ... .|.|||||||| | .||....
afLFlGskksaadlealkalgvtrivnatkerdnaldqr.gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidf

TRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
 | ||.|| .|||. |.  .|| ||   | ..
krvslkealalvkskrryvdpnlgfLkqLael
subfamily_Slingshot_pd Subfamily Slingshot 338-472 3.6e-35 114.8 In-house 19-151 (169) alignment 
Range on Protein: 338-472
Range on HMM: 19-151/169.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNpmFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
 ||. |..|.|||  ||||| ||.||...|.| ....||||...  ||| .... |.. .|.   ...  .|||.| . . |...||.||||||..  . 
askifdhvylGsewnasnleelkengveyilnvtkeidnffpek..feylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLL
. ||. ..||||| . ||. | . .||.||   | 
yamkeyglsleealeyvkerrsvikPnkgflkqle
DSPc Dual specificity phosphatase, catalytic domain 345-475 4.4e-35 115.4 Pfam-A 1-131 (133) alignment 
Range on Protein: 345-475
Range on HMM: 1-131/133.0
LYMGSETVASnLEILKSNGITHIINASHQCDN-FFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTT
||.||.. || |..|. .|||..||......| ... .. .|| .. ..|.  ..||  .|...||||.|.. ..|...|||.|.||| .|.. ..||| 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
..||.|| ..||. |.. .|||||. .||.. 
nlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 345-475 4.4e-35 115.4 In-house 1-131 (133) alignment 
Range on Protein: 345-475
Range on HMM: 1-131/133.0
LYMGSETVASnLEILKSNGITHIINASHQCDN-FFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTT
||.||.. || |..|. .|||..||......| ... .. .|| .. ..|.  ..||  .|...||||.|.. ..|...|||.|.||| .|.. ..||| 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
..||.|| ..||. |.. .|||||. .||.. 
nlslneAyefvkerrskispnagflrqLleye
subfamily_DSP10_pd Subfamily DSP10 338-474 1.3e-34 113.4 In-house 14-149 (159) alignment 
Range on Protein: 338-474
Range on HMM: 14-149/159.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
 |.|  .|..|||. |..|..|.  .||...|   .. |.|..   ..|... ..|.  ....  ||. .|||| |  .. ....||| |.|||. . . 
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..|| .. ||..| ..||. |||  || .|   ||..
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlef
subfamily_DSP14_pd Subfamily DSP14 338-474 2e-34 112.8 In-house 7-140 (157) alignment 
Range on Protein: 338-474
Range on HMM: 7-140/157.0
CSKVTDYLYMGsETVASNLEILKSNGITHIINASHQCDNffQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
.|..|..|...  ..|.. | ||...||.|||.. .  |  .. . .|. |. ..|.| ....  |..|.. || . . .||. .|| .|||||  ||. 
lsqitpsLfls.gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcla

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..||. . ||.||  |||..||| ||| ||   | ..
ylmkyeklsLreayklvksaRpiirPNvGFwkqlidy
0048179 (Phosphotyrosine protein) phosphatases II 338-474 4.9e-33 109.2 In-house 4-140 (144) alignment 
Range on Protein: 338-474
Range on HMM: 4-140/144.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
 |.....||.||  .|..|| ||..|||..|| ...... |  .. ..| .| . | .  |..  .....||||.|.. .|....||..||.|. .|...
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..||. ..||||| .||.. ||.. || |.   ||..
ylmkklglsleealalvrsrrpgavpnpgqlrfLley
0048076 (Phosphotyrosine protein) phosphatases II 338-475 1.5e-32 107.6 In-house 4-139 (145) alignment 
Range on Protein: 338-475
Range on HMM: 4-139/145.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFqdNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
 |.....|| || ..|..|| ||..|||...| .. .....  .  ..|  | . | .  |..  .....||||.|.. .|....||..||.|. .|...
pseilpglylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
..|.. ..||||| .||.. ||.. || |..  |. . 
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefe
0041856 (Phosphotyrosine protein) phosphatases II 322-477 5.9e-32 106.1 In-house 17-171 (182) alignment 
Range on Protein: 322-477
Range on HMM: 17-171/182.0
RwlgcdldklktydpICSKVTDYLYMGSETV--------------ASNLEILKSNGITHIINAShqCDNFFQDNPMF---EYRKLHLRDSPLEDislvFE
|               .......||.||                 |..|. ||..|||.|.|..  ... . .. .    .|..|   | .  |    ..
r..............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ld

QVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRP--ISRPNAGFQLSLLNWAIK
....|||.... .|....|| .||.|. .|.....||. ..||||| .||.. ||  . .|| .| | |. . ..
elldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_DSP6_pd Subfamily DSP6 336-474 3.9e-31 101.7 In-house 12-150 (158) alignment 
Range on Protein: 336-474
Range on HMM: 12-150/158.0
PICSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLC
 .  .....||.||.. |||||.||  .| ...|  .. .|.|.... ..| .. ..|   ....  | . ||||. |   . |...||  |.|||  ..
efpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvt

MLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
. ..||.. .||..| ||||. ..   ||  |   ||..
laylmkklalslndaydlvkkrksnisPnfnfmgqlldf
subfamily_DSP12_pd Subfamily DSP12 339-474 4.3e-31 102.4 In-house 3-139 (155) alignment 
Range on Protein: 339-474
Range on HMM: 3-139/155.0
SKVTDYLYMGSETVASNLEILKSNGITHIINASHQ-CDNFFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
|.... ||.|. . . . | ||. .|||..   ..  ... ...   ........|.| |||   ......||| |.. .|....|||.|||||. ... 
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..||....|||.| .|||...|  .||.||.  |  .
YlmkkeklslekAlklvkekkpeiepNegFleQLklf
subfamily_DSP15_pd Subfamily DSP15 339-475 9.1e-30 97.7 In-house 3-136 (151) alignment 
Range on Protein: 339-475
Range on HMM: 3-136/151.0
SKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnpmFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLW
|||   ||.|  ..... | || . ||||.. . .  ....|   .||. ... |.|  ..| .|.. .||| ..   ......|| .|||||  |....
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd...ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaY

IMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
.|  |  . ..| . .|. | .. ||.||.  | .. 
lmtvtelnwrdalevikaaRsvanPnfGfkrqlkeye
subfamily_DSP3_pd Subfamily DSP3 338-471 2.8e-29 95.9 In-house 11-150 (162) alignment 
Range on Protein: 338-471
Range on HMM: 11-150/162.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQ------C-DNFFQDNPmFEYRKLHLRDSPLEDISLVFEQVIEFIERAIAC-NGKIFIHCQMGVS
.  |.. ||.| |.||.. . ||  ||||..||..         ..|..|   ..|  |...|.|  |.|  ||.. .||..|..  .||...||..|||
vdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdle.ikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvs

RSSCLCMLWIMKTTRCSLEEASDLVKQVRPIsRPNAGFQLSL
||. | . ..| . . .| ||   |.. | | .|| ||   |
RsatlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqL
0043147 (Phosphotyrosine protein) phosphatases II 337-473 4.9e-28 93.4 In-house 18-155 (172) alignment 
Range on Protein: 337-473
Range on HMM: 18-155/172.0
ICSKVTDYLYMGSETVASNLEILKSNGITHIINASHQ-CDNFFQDNPMFEYRKLHLRDSPLEdISLVFEQVIEFIER--AIACNGKIFIHCQMGVSRSSC
|  .. ........|.|.... ||..|||||.|.    .|  .     ..|  |   | .   .. ......|||..  |.  .|.. .|| .||.|. .
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

LCMLWIMKtTRCSLEEASDLVKQVRPISRPNAGFQLSLLN
|.....|.  ..||||| .||.. ||.. .| ...  |. 
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyy
0045098 (Phosphotyrosine protein) phosphatases II 317-477 8.3e-28 93.0 In-house 3-270 (278) alignment 
Range on Protein: 317-477
Range on HMM: 3-270/278.0
PLESSRWLGCDLDKLKTYDPicSKVTDYLYMGSET-----------------------------------------VASNLEILKSNGITHIINASHQ--
.| |...|     .| ...|  |..|..|| |.                                           ||.... |...|||.|... .   
alasldlllefefllllgip..seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelve

------------------------------------------------CDNFFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIA----------
                                                 |.      .. |      ..| ..|.  | ...|||..|..          
lgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

----CNGKIFIHCQMGVSRSSCLCMLWIMKTT---RCSLEEASDLVKQVRPI-SRPNAGFQLSLLNWAIK
     .|....||..||.|. .|.....|..    ...|.|| . ... ||. . .| ...  |  ....
llldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyeflle
subfamily_DSP8_pd Subfamily DSP8 338-475 1.1e-27 90.5 In-house 15-151 (159) alignment 
Range on Protein: 338-475
Range on HMM: 15-151/159.0
CSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFfQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCML
  .....||.||.... . |.|. .||....|||..| .  .  .  .. .. ..|.  |... .|.. .|||..| . ||....|.  | |||. . . 
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkl.eelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaia

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
.|||| . ||.||   ||. ||   ||  |.  ||.. 
yimktlemsldeayrfvkekrptispnlnflgqLleye
subfamily_MKPLT_pd Subfamily MKPLT 329-474 2.8e-27 89.3 In-house 15-156 (164) alignment 
Range on Protein: 329-474
Range on HMM: 15-156/164.0
DKLKTYDPICskVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnpMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGV
 ..|.|  .   . | ||.|    | | ..||   ||||.| | .. . |     .|| .... | . | .|  .|.. .|.  ||   |....||..|.
krikiypsvv..ledtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGk

SRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
||||.  . ...|  .  |.|| . .|. | | .|| ||   | ..
srsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakf
subfamily_MKPLV_pd Subfamily MKPLV 329-474 2.8e-27 89.3 In-house 15-156 (164) alignment 
Range on Protein: 329-474
Range on HMM: 15-156/164.0
DKLKTYDPICskVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnpMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGV
 ..|.|  .   . | ||.|    | | ..||   ||||.| | .. . |     .|| .... | . | .|  .|.. .|.  ||   |....||..|.
krikiypsvv..ledtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGk

SRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
||||.  . ...|  .  |.|| . .|. | | .|| ||   | ..
srsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakf
0040439 (Phosphotyrosine protein) phosphatases II 315-475 4.8e-27 90.6 In-house 20-242 (249) alignment 
Range on Protein: 315-475
Range on HMM: 20-242/249.0
EEPLESSRWLGCDLDKLKTYDPICSKVTDYLYMG----------SETVASNLEILKSNGITHIINASHQCDNFF--------------------------
  |...||.   .|..|   | |.  . |. |..          .|||..... |. .|||.|..... . . .                          
ilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsve

---------------QDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIA------CNGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASD
               .|.. .... ..  | |  ...  ||....|||..        ..|....|| .||.|. .......|     |. . .|||| .
vkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavk

LVKQVRPISRPNAGFQLSLLNWA
|... || . .| ..   |....
llrsqRpgavqnpeqyrflyeal
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 339-474 6.7e-27 87.7 In-house 4-148 (154) alignment 
Range on Protein: 339-474
Range on HMM: 4-148/154.0
SKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDN-------PMFEYRKLHLRDSPLEDISLVFEQVIEFIERAI--ACNGKIFIHCQMGVS
||.. .||..|   | |   |. . |..|.| .   .| | |.        ..|| .|.| | .  ||   .... |||. ||    |.|...|.. |||
skeaiflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvs

RSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
||..| . ..|.  . || .|  |.|. |.| .|| ||   |  .
rsaallisylmdklkislslalellkdsryiikPnqGflkqleif
0049260 (Phosphotyrosine protein) phosphatases II 340-473 6.2e-26 86.3 In-house 10-144 (152) alignment 
Range on Protein: 340-473
Range on HMM: 10-144/152.0
KVTDYLYMGSETVASNLEILKSNGITHIINASHQCDN-FFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIER-AIACNGKIFIHCQMGVSRSSCLCML
... ....|..|.|.... ||..|||.|..    ... ... .  ..|  |   |..  |.| .......|||. |.  .|....||  ||.|. .|...
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaa

WIMKtTRCSLEEASDLVKQVRPISRPNAGFQLSLLN
..|.  ..||||| .||.. ||.. || |.   |..
ylml.lgvsleeavalvrekRpgavpnpgqlrflye
PTEN_1 334-472 1.6e-25 85.1 In-house 37-185 (196) alignment 
Range on Protein: 334-472
Range on HMM: 37-185/196.0
YDPICSKVTDYLYMGSETVA-SNLEILKSNGITHIINASHQCDN-------FFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIA--CNGKIFIH
 .|..... . ||.||.. . ..|. ||..|||...| |. ...        .  .  .||.... .| .  ..| .|. . .||| ...  ..... .|
srpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVH

CQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLL
|. |..|| .... . |.. . . .|| .||.. ||  .|| ..|  ||
CkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerll
0049772 (Phosphotyrosine protein) phosphatases II 206-478 6.7e-25 83.9 In-house 45-273 (314) alignment 
Range on Protein: 206-478
Range on HMM: 45-273/314.0
PNLNMLNTYDTPilMDPiNKKLNnNTFNNNNNNNIHNNFNNNFNNNIIRLEKidINNNNNNNCNNSQIDLNNNNNIINSNNNNNKNNI------------
.| ......| .    . |     ....... . |. .. ..|.. |.   .   ... ..  . ... .|  . .... .|     .            
lnrdknryldil..pad.nrvil.pglpvsgsdyinasyvdgflkfIatqgp..leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------HNNIDNNNnnslnnninsdkieeplessrwlgcdldklktydpicskvtdylymgSETVASNLEILKsngithiinaSHQCDNFFQDNPMF
          ...| |.                                               .| .|..|| ||          . ..|. .  .. .
LdaAlgKtpllildgng...............................................neptaadlellk..........eelydpelferlgi

EYRKLHLRDsPLEDISLVFEQVIEFIERAiACNGKIFIHCQMGVSRSSC-LCMLWIMKTTRCSLEEASDLVKQVRPiSRPNAGFQLSLLNWAIKE
.|  ... | . ....  |....||||.|   .|....||..|..|. . ... ..||  ..||||| . |.. ||  .|| ||  .|...  ..
kylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
0046846 (Phosphotyrosine protein) phosphatases II 333-474 7.2e-25 83.2 In-house 7-168 (176) alignment 
Range on Protein: 333-474
Range on HMM: 7-168/176.0
TYDPICSKVTDYLYMGSET----------VASNLEILKSNGITHIINASHQ-------CDNFFQD--NPMFEYRKLHLRDSPLEDIsLVFEQVIEFIERA
..|. .. ....|..||            .|..|| ||..|||...|           |.|....  .. ..|  |. .|    |.   .....|||..|
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirea

IACNGKIFIHCQMGVSRSSCLCMLWIMKT-TRCSLEEASDLVKQVRP-ISRPNAGFQLSLLNW
.  .|.. .||..|..|. .|........    |.||| .||...||  . .. ..   |  .
lkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyef
0040438 (Phosphotyrosine protein) phosphatases II 242-475 2.2e-24 81.7 In-house 9-272 (317) alignment 
Range on Protein: 242-475
Range on HMM: 9-272/317.0
NNFNNNFNNNIIRLEKIDINNNNNNNCNNSQIDLNNNNNIINSNNNNNKNNIHNNIDNNNNNslNNNINSDKIEEPLESSRWLGCDLDKlktydpicskv
 .. .. ...... | .|. ... .... ..   | . | . .   .  . .. . ... ..  .. || . .. | .. ... .   .           
lldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdld..sdYInAsyvdgpnlkrkfIatqgPl...........

tdylymgSETVASNLEILKSNGITHIINASHQCDN--------------------------FFQdNPMFEYRKLHLRDS----------------PLEDI
       ..||.. .. .. .|.|.|..  . ...                          ... .. ...|.|.. |.                |  ..
.......pntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgv

SLVFEQVIEFIERAIAC----NGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
   ......|.|.. ..    .|.. .|| .||.|. .......|     |. ....||| . ... || . .. ..   |  ..
ppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydal
0051082 (Phosphotyrosine protein) phosphatases II 339-470 2.5e-24 81.0 In-house 9-145 (151) alignment 
Range on Protein: 339-470
Range on HMM: 9-145/151.0
SKVTDYLYMGSETVASNLEILKSNGITHIINASH-----QCDNFFQDNPmFEYRKLHLRDSPLEDISLVFEQVIEFIERAIAC-NGKIFIHCQMGVSRSS
| ||..|| ..   | .|| ||..||..|.|         | ......  .|.. ... | |  ...| |..|.||.| .... ||....|| .|..|. 
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

CLCMLWIMKtTRCSLEEASDLVKQVRP-ISRPNAGFQLS
.|..|..|.  ..||||| . ... || . .|| .|.. 
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfq
0036282 (Phosphotyrosine protein) phosphatases II 340-472 6.5e-23 76.7 In-house 14-163 (174) alignment 
Range on Protein: 340-472
Range on HMM: 14-163/174.0
KVTDYLYMGSETVAsNLEILKSNGITHIINASHQCDN-------------FFQDNPMFEYRKLHLRDSPLEDISLvFEQVIEFIERAIAC--NGKIFIHC
 .|..|. |.   | ..| ||..|||....  . . .              .  .  ..| .|.  |    |.|  ......|.|.|..   .|.. .||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

QMGVSRSSCLCMLWIMKTTRC-SLEEASDLVKQVR---PISRPNAGFQLSLL
 .||.|. .|.....|..  . ||..| |||...|   | . .. ..   | 
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly
0045450 (Phosphotyrosine protein) phosphatases II 350-475 7.7e-23 77.1 In-house 118-300 (307) alignment 
Range on Protein: 350-475
Range on HMM: 118-300/307.0
ETVASNLEILKSNGITHIINASHQCDNFFQ--------------------------DNPMFEYRKLHLRDS-----------------PLEDISLVFEQV
|||.. .. |. .|.|.|.. .. ... ..                            . . .|.|.. |.                 |  ...  ||..
etvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

IEFIERAIA------CNGKIFIHCQMGVSRSSCLCMLWIMKTTR--------CSLEEASDLVKQVRPISRPNAGFQLSLLNWA
..|||.. .      ..|.. .|| .||.|. .......|.. .        ..|.|| .|... || . .| ..   | ...
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0037934 (Phosphotyrosine protein) phosphatases II 337-474 9.9e-23 76.4 In-house 20-237 (243) alignment 
Range on Protein: 337-474
Range on HMM: 20-237/243.0
IC------------------SKVTDYLYMGSE--------TVASNLEILKSNGITHIINASHQC------------------------------------
..                  ..||..|. ..         ..||... |...|||.|..  . .                                    
lpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvr

---------DNFFqdNPMFEYRKLHLRD----SPLEDISLVFEQVIEFIER-----AIACNGKIFIHCQMGVSRSSCLCMLWIMKTT-RCSLEEASDLVK
         |...     . |  |   |    .  ||.   ...|.||||.     |.  .|.. .|| .||.|. .|.....|..  ...|||| .|..
tlllenldlddlt..rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllr

QVRPI-SRPNAGFQLSLLNW
. ||  . .. ..   |  .
eqRpgkavqtpsqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 317-474 2.2e-22 75.1 In-house 20-238 (245) alignment 
Range on Protein: 317-474
Range on HMM: 20-238/245.0
PLESSRWLGCDLDKLKTYDPI------CSKVTDYLYMGSETVASNLE----ILKSNGITHIINASHQCD-------------------------------
|....|    . .     |.|      ....|. .....   ....|     |...|||.|.. .   .                               
pydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehl

-------------NFFQDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIA--CNGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVK
               ..    . |. |.  | .  |..  .....||...|.|   ||....|| .||.|. .......|     |. . ||||| . ..
ddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelr

QVRPISRPNAGFQLSLLNW
. || .... ..   |  .
sqRpgavqtpsqyrflyea
0036941 (Phosphotyrosine protein) phosphatases II 332-474 9.2e-20 66.6 In-house 13-272 (297) alignment 
Range on Protein: 332-474
Range on HMM: 13-272/297.0
KTYDPICSKVTDYLYMGSETVASNLEILK----------------------------------------------------------SNGITHIINASHQ
  .   .......|..|| .||...| |.                                                           ...|.|.. .  
alllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltel

CD-------NFF--------------------------------------QDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIA------CNGKIFI
 .        ..                                      .... .. . .|  . |  ..   ......|||..         .|.. .
velgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlV

HCQMGVSRSSCLCMLWIM--------KTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
|| .||.|| .......|        |. .... ||   ... || . .. .. . |  .
HCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
subfamily_STYX_pd Subfamily STYX 345-474 3.2e-19 62.6 In-house 19-153 (166) alignment 
Range on Protein: 345-474
Range on HMM: 19-153/166.0
LYMG--SETVASNLEILKSNGITHIINASHQCD-NFFQDN--PMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWI
|..|  | .. | ||.||..|||||.    . . |. . |    | |  | . |...|.|   . .| |||. ..   ||...| . |.|||..| . .|
lflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayi

MKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
|.|      ||   |.. |    ||.||   | ..
metyglkyreafayvqerrfcinpnegfvsqlkey
0039614 (Phosphotyrosine protein) phosphatases II 349-475 1.9e-16 55.8 In-house 111-285 (297) alignment 
Range on Protein: 349-475
Range on HMM: 111-285/297.0
SETVASNLEILKSNGITHIINASHQCDN------------------------FFQdNPMFEYRKLHL-----------------RDSPLEDISLVFEQVI
.|||.. .. .. .|.|.|..    ...                        ... .... .|.|..                  |    ... .. ...
petvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllefl

EFIERAIA---CNGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
|....|.|    .|.. .|| .||.|. .......|     |. . ...|| . ... || .... ..   | ...
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
0051429 (Phosphotyrosine protein) phosphatases II 348-475 1.1e-15 53.6 In-house 27-221 (272) alignment 
Range on Protein: 348-475
Range on HMM: 27-221/272.0
GSET---VASNLEILKSNGITHIINASHQC----DNFFQDNPMFEYRKLHLRDSPLEDISLVF-------------------------------------
..      | ... ||..||..|..  . .    .....  | ..|  |.. |.  ..|.. .                                     
sggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlh

-----------EQVIEFIERAIAcNGKIFIHCQMGVSRSSCLCMLWIMKtTRCS--------------LEEASDLVKQVRPISRPNAGFQLSLLNWA
           |...|..|   . .|.. .||  |..|. ....|...   . |              |||| . ....|| .... .. | |....
ytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 345-474 5.2e-15 48.8 In-house 6-137 (145) alignment 
Range on Protein: 345-474
Range on HMM: 6-137/145.0
LYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNPMFEYRKLHLRDSPLE--DISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKT
||.||   |... .|.  ||. |.| .       |.    ..  | .  . ||  |.|  |..| .||..       .|.||  |||||  . . ..|| 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

TRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
   .| ||.  |.  |  . ||  |  .||| 
cnmtlseaarqvrsnrllaypnvtflknllnl
subfamily_STYXL1_pd Subfamily STYXL1 327-475 9.6e-15 48.1 In-house 3-150 (157) alignment 
Range on Protein: 327-475
Range on HMM: 3-150/157.0
DLDKLKTYdPIcSKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDNPM-FEYRKLHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQ
.||.|||| |.   . . ||.| .  | | .| |   .   .| |...|....  .   .  .... |..  |.   ......|||.    .  ...  .
eldelkty.Pv.evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsn

MGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNWA
 |.||| .. . ..|   . .|..| . .|. ..  .|| .|   | .| 
kGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWe
subfamily_MSG5_pd Subfamily MSG5 365-476 2.1e-14 47.0 In-house 49-158 (165) alignment 
Range on Protein: 365-476
Range on HMM: 49-158/165.0
THIINASHQCDNFFQDNPMFEYRklHLRDSPLEDISLVFEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISRPN
  .|| ... ...    |  .|   |..      | . . .. . |  | . . ||..||| |.|||..| . .|||    ||..| |..| |     |.
dlvinvakeindlellvpavkyy..hiewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddisps

AGFQLSLLNWAI
 |. . |..| .
iglifqlmewev
0043336 (Phosphotyrosine protein) phosphatases II 350-473 2.7e-14 48.7 In-house 99-271 (278) alignment 
Range on Protein: 350-473
Range on HMM: 99-271/278.0
ETVASNLEILKSNGITHIINAS-------HQCDNFF---------------------------------QDNPMFEYRKLHLRDSPLEDISLVFEQVIEF
|||.   . .. .|.|.|..          .|. ..                                 .|.. .. . .|  . |  ..   ......|
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

IERAIA----CNGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNAGFQLSLLN
.....     .||.. .||  ||.|. ....|...     |. . .|||| . ... || . ..  .   | .
lkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0038934 (Phosphotyrosine protein) phosphatases II 366-471 5.6e-14 47.7 In-house 57-169 (194) alignment 
Range on Protein: 366-471
Range on HMM: 57-169/194.0
HIINASHQCDNFFQDNPMFEYRKLHLRDSPLEDI--SLVFEQVIEFIERAI-----ACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVR
.    .  ..... |   || ....  . | .|   .  .|.. .|.. .        .|.. .|| .|..|. .|.  ..... ..|.||| .|....|
lglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekR

PISRPNAGFQLSL
| . || ..   |
pgaipnqdyleal
subfamily_LRR-DSP_pd Subfamily LRR-DSP 248-474 1.2e-12 41.5 In-house 32-254 (263) alignment 
Range on Protein: 248-474
Range on HMM: 32-254/263.0
FNNNIIRLEKIDINNNNNNNCNNsqidlnNNNNIINSNNNNNKNNIHNNIDNNNNN--------SLNNNINSDKIEEPLESSrwlgcDLDKLKTYD-PIC
...||   ..|. |||..||.||      ||||  . ||| ||||| . |.. . .         ||   | . |  |.|       ....| |.   . 
ydenintcnninsnnndsnnsnn......nnnnnndnnnncnknnileminsteleggglgclkelnirdnrelislpveyk.....qveslitlvssvP

SKVTDYLYMGSETVASNLEILKSNGITHIINASHQCDNFFQDnpMFEYRKL-HLRDSPLEDISLVFEQVIEFIERAIAcNGKIFIHCQMGVSRSSCLCML
... | |..|.   | |  |||..|.|||. |  ... .| .  .| |  . ...| .  |||  ||..  |||     .| ...||. |||||| | . 
deiidklflGgldsannksilkdlgvthillavadfePlfPk..lfkylsiddiedvdeadisqhfeetnafieeGrk.kGGvlvhcraGvsrsstlvis

WIMKTTRCSLEEASDLVKQVRPISRPNAGFQLSLLNW
..||  |  ..|| |||.. ||  .|| ||.  |. .
ylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkky
subfamily_PTPMT1_pd Subfamily PTPMT1 403-462 5.7e-12 40.4 In-house 93-152 (171) alignment 
Range on Protein: 403-462
Range on HMM: 93-152/171.0
FEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLVKQVRPISR
 |. .||||. .    ....||. | .||. |   ..||....|.||| . .|. |.| |
lekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiir
0051299 (Phosphotyrosine protein) phosphatases II 367-465 7.9e-12 40.7 In-house 120-272 (288) alignment 
Range on Protein: 367-465
Range on HMM: 120-272/288.0
IINASH-------QCDNFF--------------------------------------QDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIAC----N
|.           .|. ..                                      .|.  .... .|  . |  ..   .|....|..... .    .
IvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgg

GKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNA
| . .||  ||.|. ....|...     |. .....||   ... || . .. 
gpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 367-465 8.3e-12 40.5 In-house 136-285 (308) alignment 
Range on Protein: 367-465
Range on HMM: 136-285/308.0
IIN----------------------ASHQCDNFF----------------------QDNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIAC--NGKI
|.                        | ....|.                      .|....... .|  . |  ..   .|....|.|..  .  .|.|
IvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpi

FIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNA
 .||  ||.|. ....|...     |. .....||   ... || . .. 
vVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0047943 (Phosphotyrosine protein) phosphatases II 352-471 5.3e-11 37.9 In-house 90-264 (273) alignment 
Range on Protein: 352-471
Range on HMM: 90-264/273.0
VASNLEILKSNGITHIINASHQCDN-------FF-------------------------------------QDNPMFEYRKLHLRDSPLEDISLVFEQVI
|.. .  .. .....|.      ..       ..                                     ...  .... .|  . |  ..   .|...
vedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesll

EFIERAIA------CNGKIFIHCQMGVSRSSCLCMLWIM-----KTTRCSLEEASDLVKQVRPISRPNAGFQLSL
|||| .         ||.. .||  ||.|. ....|...     |. . ...||  |... || . ..  . . |
efielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0046845 (Phosphotyrosine protein) phosphatases II 344-461 6.1e-10 34.4 In-house 129-256 (284) alignment 
Range on Protein: 344-461
Range on HMM: 129-256/284.0
YLYMGSETVASNLEILKSNGITHIINASHQcdnffQ-DNPMFEYRKLHLRDSPLEDISLVFEQVIEFIERAIAC------NGKIFIHCQMGVSRSSCLCM
.|..|  ||    |  |.. ... .  ..      . ... .. . .|  . |  ..   .|...||.. .  .      .|.| .||  ||.|. ....
vltygdftvtllseevkddytvrtleltnl.....gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfia

LWIMKTT--------RCSLEEASDLVKQVRPIS
|.....         .....||   ... || .
ldllleqlekeglllgvdvleavkrlreqRpgm
subfamily_CDC14_pd Subfamily CDC14 356-460 2e-08 28.5 In-house 205-306 (328) alignment 
Range on Protein: 356-460
Range on HMM: 205-306/328.0
LEILKSNGITHIINASHQcdnfFQDNPMFEYRKLHLRDSPLEDISLVFEQVIE-FIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDLV
||  ..|..|...   ..      |.  |.   ..  |   .| |   ..... |.| |  ..|.| .||. |. |  .|   ..||. | . .||   .
leyfrknnvttvvrLnkk....lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawl

KQVRPI
. .|| 
ricrPG
0048567 (Phosphotyrosine protein) phosphatases II 384-469 4e-08 27.8 In-house 39-131 (157) alignment 
Range on Protein: 384-469
Range on HMM: 39-131/157.0
FEYRKLHLRDSPLED--ISLVFEQVIEFIERAIACNGKIFIHCQMGV---SRSSCLCMLWIMKTTRCSLEEASDLVKQVRP--ISRPNAGFQL
. |  ..  . ||.   .   . .. .|..    ....| .|| .|    .|. .|. .....  . . ||| .....|||  .  . |.. |
lvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyll
subfamily_DSP23_pd Subfamily DSP23 354-461 1.3e-06 23.2 In-house 22-128 (148) alignment 
Range on Protein: 354-461
Range on HMM: 22-128/148.0
SNLEILKSNGITHIINASHQCDNFFQDNPMFEYRKLHLRDSPLEDISLVfEQVIEFIERAIACNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLEEASDL
.... |  .|. ...  ....    .  |   . .| . |     .  | .. .. .| | . |  . .|| .|  |.  .   ...|  . .  ||   
dqyrylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqv.vefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiae

VKQVRPIS
|.. || |
vrrlrpgs
PTPc_DSPc_SM00012 403-458 8e-06 21.4 In-house 26-83 (105) alignment 
Range on Protein: 403-458
Range on HMM: 26-83/105.0
FEQVIEFIE---RaiacNGKIFIHCQMGVSRSSCLCMLWIMKTTRCSLE---EASDLVKQVR
...| .. .   .    .. . .||. ||.|. ....| |.    .. .   . ...||..|
lravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelr