Gene mkpA in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP009_AA protein Get Run
DdisP009_AA_1056-1202 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP1_pd Subfamily DSP1 1052-1204 1.6e-61 201.1 In-house 12-162 (163) alignment 
Range on Protein: 1052-1204
Range on HMM: 12-162/163.0
ILFFEPTLnRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMvCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRS
. ...|.  .|.| |||||.. ||||..|| .|||.|||.... ..|.|.|.| ||.| ..| . .|||..|.|...||....|.||||.|||..|||||
lklydPve.kildfLylGsetvasnleiLkslgitailnvske.ldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRs

SAFVILYLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLLKHLQH
|.....|||. ...|...|..|.|.||.|..|| ||..||. ..| ||..|..
stlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklllelek
0044763 (Phosphotyrosine protein) phosphatases II 1058-1200 4e-38 126.2 In-house 22-172 (178) alignment 
Range on Protein: 1058-1200
Range on HMM: 22-172/178.0
TLNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMVCPNHFQD--------HFVYKTLFISDGNGEDISCLFYEILDFIQDAT-KTNGKVYIHCHQGI
 ...|.. |||||  ||..|.||| .|||||.|... . ......        .. |. . |.|..  |..  |.|...||..|  . .|.|..||. |.
naseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGv

SRSSAFVILYLMWINKWSFQQAHEFTKKRRYiSNPNPGFTGQLMYWNKFLLK
.|| ..|..|||. ...|...| |. ..||   .||||.  ||... ..|||
gRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP10_pd Subfamily DSP10 1060-1200 6.5e-35 114.3 In-house 15-155 (159) alignment 
Range on Protein: 1060-1200
Range on HMM: 15-155/159.0
NRIVDELYLGSRIPASNLQLLKGEGITHILNCAgMVCPNHFQD-HFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILY
 ...  |.|||   |..|..|.  .||..|| .   .||.|.. .. || . .|| . ....  | | |.||..| |.. .| .||. |||||...|| |
sqvlpfLflGsekdaadldaldrlnitavlnvt.tsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

LMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLLK
||   . |...|..| |..| |  || .| |||. ..| | |
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
subfamily_DSP19_pd Subfamily DSP19 1059-1196 1.6e-34 113.4 In-house 12-148 (152) alignment 
Range on Protein: 1059-1196
Range on HMM: 12-148/152.0
LNRIVDELYLGSRIPASNLQLLKGEGITHILNCAgMVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILY
.  . ..|||||   |.. . || ..|||||| | .  ||.| ..| |... | | . .|..  . |.||||..| ...| |..||. |.|||...|| |
vgeveprlylgsqdvaadkeilkekkitHilnva.tgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviay

LMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNK
||  .. |...| |  .. |   .|| ||. ||  ...
lmkkeelsleealelvrearpcikPneGFikqLkeyea
0048076 (Phosphotyrosine protein) phosphatases II 1060-1198 4.4e-34 112.6 In-house 5-142 (145) alignment 
Range on Protein: 1060-1198
Range on HMM: 5-142/145.0
NRIVDELYLGSRIPASNLQLLKGEGITHILNCaGMVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYL
..|.. |||||   |..|.|||  |||..||.  . ...... .. |  | . | .  |.. |..|.|.||..| | .|.|..||. |..|. ..|..||
seilpglylgslptaldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFL
|. ...|...| |. ...| ...||||.  .|... . |
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 1059-1197 2e-33 110.5 In-house 4-143 (144) alignment 
Range on Protein: 1059-1197
Range on HMM: 4-143/144.0
LNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMVCPNHFQDH-FVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVIL
 ..|.. |||||   |..|.|||  |||...|..    |... .. . |  | . | .  |.. |..|.|.||..| . .|.|..||. |..|. ..|..
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKF
|||. ...|...| .. ..||....||||.  .|....|.
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
PTPc_motif_SM00404 1060-1196 2.9e-33 109.7 In-house 3-139 (140) alignment 
Range on Protein: 1060-1196
Range on HMM: 3-139/140.0
NRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYL
.|| ..|||||   |.|..|||  ||||..|..  |  .  . .| .. . ..| . ...|  . ..||||..|.|..|||..||  |.||| ...| ||
srilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYl

MWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNK
|. ...| ..| || |.|| | .|| .|. ||. ..|
mryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_Slingshot_pd Subfamily Slingshot 1059-1199 9e-33 107.0 In-house 19-158 (169) alignment 
Range on Protein: 1059-1199
Range on HMM: 19-158/169.0
LNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGmVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILY
  .| | .||||   ||||. || .|...||| .   . |.|...| |... . | . .|.   . |  .||. | |.. || .||  |.|||.. || |
askifdhvylGsewnasnleelkengveyilnvtk.eidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

LMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLL
 |   ..|...|.|. |.|| . .||.||. ||  ..  | 
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGile
0041856 (Phosphotyrosine protein) phosphatases II 1057-1201 1.4e-32 108.1 In-house 17-175 (182) alignment 
Range on Protein: 1057-1201
Range on HMM: 17-175/182.0
PTLNRIVDELYLGSRIP--------------ASNLQLLKGEGITHILNCAgmvCPNHFQDHF-----VYKTLFISDGNGEDisclFYEILDFIQDATKTN
. |..| . |||||. .              |..|..||..|||.|.|..   ..... ...      |. |.. |..  |    ..|.||||... . .
rdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeg

GKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKRRY--ISNPNPGFTGQLMYWNKFLLKH
|.|..||. |..|. ..|..|||. ...|...| .. ..||   . .|| .|  ||... ..||| 
gpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_DSP12_pd Subfamily DSP12 1060-1200 3.6e-31 102.7 In-house 3-145 (155) alignment 
Range on Protein: 1060-1200
Range on HMM: 3-145/155.0
NRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMVCPNHFQDHF-V-YKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVIL
.|| ..||||.  .. . .|||  .|||.|  . .  |.| ...  | .|.. | | . |||   . |..|||..| ...|.|..||. |.|||...|| 
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLLK
|||  .|.|...|... |. .   .|| ||  ||  ..|   |
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgck
0046846 (Phosphotyrosine protein) phosphatases II 1053-1200 1.3e-30 101.9 In-house 6-174 (176) alignment 
Range on Protein: 1053-1200
Range on HMM: 6-174/176.0
LFFEPTLNRIVDELYLGSRI----------PASNLQLLKGEGITHILNCAGMV------CPNHFQD----HFVYKTLFISDGNGEDIsCLFYEILDFIQD
|.... |..|.. |.||||            |..|..|| .|||...|.  .|      |||....    .. |. | . |..  |.  |..|.|.||..
lgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefire

ATKTNGKVYIHCHQGISRSSAFVILYLMWI-NKWSFQQAHEFTKKRRY-ISNPNPGFTGQLMYWNKFLLK
| | .|.|..||. ||.|. ..|..||..  . .| ..| .. ...|   . ..|..  .|... ..|||
alkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
subfamily_DSP15_pd Subfamily DSP15 1059-1202 1.5e-30 100.3 In-house 2-143 (151) alignment 
Range on Protein: 1059-1202
Range on HMM: 2-143/151.0
LNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGmvCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILY
..... .|||| .. ... .||| . |||||.      .... ... ||.. .||  . ..|  | |  .|| ..   ...|..||  |.|||   |..|
iskvlpglylgnfrdskdeelLkeknithilsvhd..nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaY

LMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLLKHL
|| . . ....| |. |..| ..||| ||  ||. ..|. ||..
lmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkey
0043147 (Phosphotyrosine protein) phosphatases II 1059-1201 9.3e-30 99.0 In-house 19-163 (172) alignment 
Range on Protein: 1059-1201
Range on HMM: 19-163/172.0
LNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGM--VCPNHFQDHFVYKTLFISDGNGEdISCLFYEILDFIQD--ATKTNGKVYIHCHQGISRSSAF
 .|... ......  |.....|| .|||||.|. .    ... ..  . |  | . |..   .. |..|.|.||..  | . .|.|..||. |..|. ..
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

VILYLMWiNKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLLKH
|..|||.  ..|...| .. ...| .. .||..  .|.|..|.|| .
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllll
0049772 (Phosphotyrosine protein) phosphatases II 1058-1198 3.9e-29 97.8 In-house 125-273 (314) alignment 
Range on Protein: 1058-1198
Range on HMM: 125-273/314.0
TL---------------------NRIVDELYlgSRIPASNLQLLKgegithilncagMVC--PNHFQDH-FVYKTLFISDgNGEDISCLFYEILDFIQDA
                       ..|.|...  .  .|..|.|||             ..  |..|... . |. . ..| ......  |.|.|.||..|
vmsrdevladelsrLdaAlgKtpllildgng..neptaadlellk............eelydpelferlgikylripvpD.gsaplledfdeflefieea

tKTNGKVYIHCHQGISRSS-AFVILYLMWINKWSFQQAHEFTKKRRYiSNPNPGFTGQLMYWNKFL
 ...|.|..||. |..|.  . |. |||. ...|...| |. ...|.  ||||||  ||. . . |
.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil
DSPc Dual specificity phosphatase, catalytic domain 1066-1196 6.4e-29 95.5 Pfam-A 1-132 (133) alignment 
Range on Protein: 1066-1196
Range on HMM: 1-132/133.0
LYLGSRIPASnLQLLKGEGITHILNCAGMVCPNHF--QDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWIN
|||||   || |.||.  |||...|..  |  |..  . .. |  . . | . ..||  . |. .||..|.. ..||..||  ||||| ...| |||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

KWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNK
..| ..| || |.|| . .|| ||..||. ...
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 1066-1196 6.4e-29 95.5 In-house 1-132 (133) alignment 
Range on Protein: 1066-1196
Range on HMM: 1-132/133.0
LYLGSRIPASnLQLLKGEGITHILNCAGMVCPNHF--QDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWIN
|||||   || |.||.  |||...|..  |  |..  . .. |  . . | . ..||  . |. .||..|.. ..||..||  ||||| ...| |||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

KWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNK
..| ..| || |.|| . .|| ||..||. ...
nlslneAyefvkerrskispnagflrqLleyer
0049260 (Phosphotyrosine protein) phosphatases II 1060-1198 1.7e-28 94.6 In-house 9-149 (152) alignment 
Range on Protein: 1060-1198
Range on HMM: 9-149/152.0
NRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMVCPNH--FQDHFVYKTLFISDGNGEDISCLFYEILDFIQD-ATKTNGKVYIHCHQGISRSSAFVI
....  ...|.   |.....||  |||.|...   .. ..  .  .. |. |.. |..  |.| |....|.||.  | . .|.|..||. |..|. ..|.
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

LYLMWiNKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFL
.|||. ...|...| .. ...| ...||||.  .|....|.|
aylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
subfamily_DSP6_pd Subfamily DSP6 1060-1198 2.1e-28 92.8 In-house 15-154 (158) alignment 
Range on Protein: 1060-1198
Range on HMM: 15-154/158.0
NRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMvCPNHFQD--HFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVIL
 .|.. |||||.  ||||..||  .| ..|| .    || |..  .. |. . |.|   .... .| | ..||..| ... || .||. ||||| . .. 
veilpllylGsakdasnlevlkklkikyvlnvtsn.lpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtla

YLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFL
|||  .. |...|... |||.    ||  | |||. ... |
ylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
subfamily_MKPLT_pd Subfamily MKPLT 1063-1199 2.6e-28 92.6 In-house 26-161 (164) alignment 
Range on Protein: 1063-1199
Range on HMM: 26-161/164.0
VDELYLGSRIPASNLQLLKGEGITHILNCAgMVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWI
 |.||||    | | ..||   ||||.| .   . . |   ..| .. ..|   | .|  .  . .|. || .. |.|..|| || ||||.  . .|.  
edtlylGnakhatnekvlkdlkithivnvs.qekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

NKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLL
..| ...|.|. |.|| | .|| ||  ||  .....|
kgwtlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_MKPLV_pd Subfamily MKPLV 1063-1199 2.6e-28 92.6 In-house 26-161 (164) alignment 
Range on Protein: 1063-1199
Range on HMM: 26-161/164.0
VDELYLGSRIPASNLQLLKGEGITHILNCAgMVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWI
 |.||||    | | ..||   ||||.| .   . . |   ..| .. ..|   | .|  .  . .|. || .. |.|..|| || ||||.  . .|.  
edtlylGnakhatnekvlkdlkithivnvs.qekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLiks

NKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLL
..| ...|.|. |.|| | .|| ||  ||  .....|
kgwtlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_DSP14_pd Subfamily DSP14 1058-1198 2.7e-28 92.9 In-house 6-144 (157) alignment 
Range on Protein: 1058-1198
Range on HMM: 6-144/157.0
TLNRIVDELYLGsRIPASNLQLLKGEGITHILNCAGMVcPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVIL
.|..|...|.|.    |.. .||| ..||.|.|..  . ||.  ... .  . ..| . ....  | |. | |....|..||. .||  |.||| .... 
alsqitpsLfls.gvaalskellkkkkitliinvtvel.pntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslcla

YLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFL
|||  .| | ..|.. .|..| | .|| ||  ||. . | |
ylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl
subfamily_DSP3_pd Subfamily DSP3 1058-1200 6.5e-28 91.4 In-house 10-159 (162) alignment 
Range on Protein: 1058-1200
Range on HMM: 10-159/162.0
TLNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMV------CPNHFQD-HFVYKTLFISDGNGEDISCLFYEILDFIQDATKT-NGKVYIHCHQGIS
... . ..||.| .  |.. . ||  ||||.||.|          .....| .. |  | ..|    |.|  |..  .||..| .. .|||..||..|.|
evdevypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvs

RSSAFVILYLMWINKWSFQQAHEFTKKRRYISnPNPGFTGQLMYWNKFLLK
||.. |. |||  .| . ..| .  .|.| |  || ||  ||.  .. | .
RsatlvlayLmirrkmtlveairtvrkkReil.PneGFlkqLaeldeelkr
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 1066-1195 9.5e-28 90.6 In-house 15-144 (148) alignment 
Range on Protein: 1066-1195
Range on HMM: 15-144/148.0
LYLGSRIPASNLQLLKGEGITHILNCAGmVCPNHFQDHFV-YKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWINK
|.|||.  |..|. ||  |.|.| |..   ..| .... . |  . ..| . ||.|..| .| .|.. | .  ..| .|.. |.||||| ..|.|.  ..
LFlGskksaadlealkalgvtrivnatk.erdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkr

WSFQQAHEFTKKRRYISNPNPGFTGQLMYWN
 | ..| .. | .|   .||.||  ||  ..
vslkealalvkskrryvdpnlgfLkqLaele
subfamily_DSP8_pd Subfamily DSP8 1059-1199 2.8e-26 86.0 In-house 15-155 (159) alignment 
Range on Protein: 1059-1199
Range on HMM: 15-155/159.0
LNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILY
..||.. |||||.  . . .||.  ||...||        ..  .  .  . . | . |...  | . ..||. | ..||.| .|.. |||||.. .| |
ptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiay

LMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLL
.|   . |...|..| |..|   .||  | |||. ..| | 
imktlemsldeayrfvkekrptispnlnflgqLleyekelk
subfamily_STYX_pd Subfamily STYX 1059-1202 4.3e-26 85.0 In-house 12-161 (166) alignment 
Range on Protein: 1059-1202
Range on HMM: 12-161/166.0
LNRIVDELYLGSRIPA--SNLQLLKGEGITHILNC-----AGMVCPNhFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRS
.. |.  |.||    |  | |. || .|||||.       | .. || |.|.| |  | ..|   |.|   . .. .||.|. .. ||| .|   |||||
mqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpn.fpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrs

SAFVILYLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLLKHL
.|.|| |.|      ...|. . ..||.  ||| ||. ||. ..   | .|
aalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakl
subfamily_LRR-DSP_pd Subfamily LRR-DSP 1049-1199 9.3e-26 84.5 In-house 110-259 (263) alignment 
Range on Protein: 1049-1199
Range on HMM: 110-259/263.0
KELILFFEPTLNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMVCPnHFQDHFVYKTL-FISDGNGEDISCLFYEILDFIQDATKtNGKVYIHCHQG
..||..     . |.|.|.||..  | |  .||  |.|||| . . . |  | . | | ..  | | .  |||  | |.  ||..  | .| | .||  |
eslitlvssvPdeiidklflGgldsannksilkdlgvthillavadfeP.lfPklfkylsiddiedvdeadisqhfeetnafieeGrk.kGGvlvhcraG

ISRSSAFVILYLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLL
.||||. || |||  ..  |..| ....|.|   .|||||  ||. ..| | 
vsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
0036282 (Phosphotyrosine protein) phosphatases II 1059-1198 5.2e-25 83.6 In-house 12-169 (174) alignment 
Range on Protein: 1059-1198
Range on HMM: 12-169/174.0
LNRIVDELYLGSRIPAsNLQLLKGEGITHILNCAGMVCPN--------------HFQDHFVYKTLFISDGNGEDISClFYEILDFIQDATKT--NGKVYI
|..| ..|..|.   | ....|| .|||.....   . ..                . .. |. | . |..  |.|  ..|...|...| .   .|.|..
lsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlV

HCHQGISRSSAFVILYLMWINKW-SFQQAHEFTKKRR---YISNPNPGFTGQLMYWNKFL
||. |..|. ..|..|||  ... |...| .. ...|     . ..|..  .| |..|.|
HCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0045098 (Phosphotyrosine protein) phosphatases II 1050-1201 7.2e-25 83.3 In-house 13-274 (278) alignment 
Range on Protein: 1050-1201
Range on HMM: 13-274/278.0
ELILFFEPTLNRIVDELYLGSRI-----------------------------------------PASNLQLLKGEGITHILNCAG---------------
   |.  .  ..| . ||||..                                           |.....|. .|||.|.....               
fefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

------------------------------------MVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATK--------------TNGKVYIH
                                      .....  |. |..    .   ..|.  | |.|.||..| |               .|.|..|
ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CHQGISRSSAFVILYLMWIN---KWSFQQAHEFTKKRRYI-SNPNPGFTGQLMYWNKFLLKH
|. |..|. ..|..|||  .   ......| .. ...| . . .|...  .|...   ||..
CsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0037934 (Phosphotyrosine protein) phosphatases II 1058-1198 1.8e-24 82.1 In-house 38-241 (243) alignment 
Range on Protein: 1058-1198
Range on HMM: 38-241/243.0
TLNRIVDELYLGSR--------IPASNLQLLKGEGITHILNCAGMV--------------------------------------------CPNHFQDHFV
 | .... |....         ..||....|. .|||.|...   |                                            ...... .. 
nliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvih

YKTLFISD----GNGEDISCLFYEILDFIQD-----ATKTNGKVYIHCHQGISRSSAFVILYLMWIN-KWSFQQAHEFTKKRRYI-SNPNPGFTGQLMYW
|  | . |     . ||.  .. |. .||..     | ...|.|..||. |..|. .....|||  . ......| .. ...|   . ..|..  .|...
yhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea

NKFL
 ..|
llel
0045450 (Phosphotyrosine protein) phosphatases II 1056-1199 7.4e-24 80.5 In-house 55-304 (307) alignment 
Range on Protein: 1056-1199
Range on HMM: 55-304/307.0
EPTLNRIVDELYL----------------GSRIPASNL--------------------------------QLLKGEGITHILNCAGMVCPNH--------
  ..||..| |..                .. | ||                                  ..|. .|.|.|... . |  ..        
nkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywP

-------------------FQDHFVYKTLFISDG-----------------NGEDISCLFYEILDFIQDATK------TNGKVYIHCHQGISRSSAFVIL
                    .|.... || ..|                   . ...  | |.||||. . |       .|.|..||. |..|. .|...
degeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaa

YLMWINK--------WSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLL
|||. .         .....| .. ...|. . .||..  .|... ..||
ylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
PTEN_1 1059-1199 1.1e-23 79.1 In-house 41-192 (196) alignment 
Range on Protein: 1059-1199
Range on HMM: 41-192/196.0
LNRIVDELYLGSRIPA-SNLQLLKGEGITHILNCAG----MVCPN----HFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKT--NGKVYIHCHQG
| .| . ||.||.  . ..|. ||..|||...| .     . ..     .|. .. |. . | | .  ..|.|| .. .||. . .   ...|..||..|
lqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaG

ISRSSAFVILYLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLL
..||   |. |||. .|.....| |. ...|   .||...  .|..  . ||
lgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell
0040439 (Phosphotyrosine protein) phosphatases II 1060-1199 4.1e-23 77.7 In-house 15-246 (249) alignment 
Range on Protein: 1060-1199
Range on HMM: 15-246/249.0
NRIV---------------DELYLGSRIPASNLQ------------------------LLKGEGITHILNCAGMVCPN----------------------
||..               ..|.|.. | || .                         .|. .|||.|...   | ..                      
nrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvt

--------------------HFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATK------TNGKVYIHCHQGISRSSAFVILYLM-----WINKWSF
                     ..... .. . . |    ...  | ..||||. . |      ..|.|..||. |..|. .|...|||     . .....
llsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdl

QQAHEFTKKRRYISNPNPGFTGQLMYWNKFLL
..| .. ...|. . .||..  .|... ..||
eeavkllrsqRpgavqnpeqyrflyeallell
0051082 (Phosphotyrosine protein) phosphatases II 1059-1192 8.9e-23 76.0 In-house 8-147 (151) alignment 
Range on Protein: 1059-1192
Range on HMM: 8-147/151.0
LNRIVDELYLGSRIPASNLQLLKGEGITHILNCAGMV----CPNHFQD-HFVYKTLFISDGNGEDISCLFYEILDFIQDATKT-NGKVYIHCHQGISRSS
.... . ||...   | .|.||| .||..|.|. . .    ||. ...  . .. . | |    ... .| ..|.|.. . .. ||.|..||. |..|. 
fsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

AFVILYLMWiNKWSFQQAHEFTKKRRY-ISNPNPGFTGQLM
..|.||||   ..|...| |. ...|  . .|| .|  ||.
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
0042113 (Phosphotyrosine protein) phosphatases II 1060-1199 7.9e-21 70.0 In-house 48-243 (245) alignment 
Range on Protein: 1060-1199
Range on HMM: 48-243/245.0
NRIVDELYLGSRIPASNLQ----LLKGEGITHILNCAGMV---------------------------------------------CPNHFQDHFVYKTLF
 || . .....   .....    .|. .|||.|...   .                                               .  . ...|  | 
yritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylp

ISDGNGEDISCLFYEILDFIQDATK--TNGKVYIHCHQGISRSSAFVILYLM-----WINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLL
. |..  |.. |. ..|.|...| .   ||.|..||. |..|. .|...|||        ..|...| .. ...|. . ..|..  .|... ..||
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
0040438 (Phosphotyrosine protein) phosphatases II 1073-1212 1.9e-20 68.8 In-house 94-290 (317) alignment 
Range on Protein: 1073-1212
Range on HMM: 94-290/317.0
PASN-----LQLLKGEGITHILNCAGMVCPN--------------------------HFQDHFVYKTLFISDG----------------NGEDISCLFYE
| .|     ..... .|.|.|..    . ..                          .  ..... || ..|                    ..   . .
PlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdl

ILDFIQDATKT----NGKVYIHCHQGISRSSAFVILYLM-----WINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWN-KFLLKHLQHPSVKEQPL
.|||.. . .     .|.| .||. |..|. .|...|||       .......| .. ...|. . ..|..  .|...  ..|...|. ....|..|
lldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselkl
0039614 (Phosphotyrosine protein) phosphatases II 1052-1201 4.4e-19 64.5 In-house 52-291 (297) alignment 
Range on Protein: 1052-1201
Range on HMM: 52-291/297.0
ILFFEPTLNRIV------------------------------------DELYLGSRIPASN-----LQLLKGEGITHILNCAGMVCPN------------
 |    ..||..                                    .  .. .  | ..     ..... .|.|.|..    |  .            
llpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg

------------HFQDHFVYKTLFIS-----------------DGNGEDISCLFYEILDFIQDATK---TNGKVYIHCHQGISRSSAFVILYLM-----W
            .  |.... || ..                 |..  ... |..|.|.....| .    .|.|..||. |..|. .|...|||      
tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlek

INKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLLKH
  ......| .. ...|. . ..|..  .|... ..|||.
eggvdvleavkelreqRpgavqtpsqyrflydallellkr
0036941 (Phosphotyrosine protein) phosphatases II 1062-1201 1.9e-17 59.0 In-house 22-279 (297) alignment 
Range on Protein: 1062-1201
Range on HMM: 22-279/297.0
IVDELYLGSR----------------------------------IPASNLQ------------------------LLKGEGITHILNCAGMV------CP
... |.|||.                                  | || ..                        ..  ...|.|..    |      |.
llpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

NHF------------------------QDHFVYKTLFISD-GN---------------GEDISCLFYEILDFIQDATK------TNGKVYIHCHQGISRS
  .                         |.... || ..| ||                 ..   ....||||. . |       .|.|..||. |..||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

SAFVILYLM--------WINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLLKH
 .|....||          ..... .|  . ...|. . .....  .| ..  .|||.
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_STYXL1_pd Subfamily STYXL1 1108-1199 1.2e-16 54.3 In-house 63-154 (157) alignment 
Range on Protein: 1108-1199
Range on HMM: 63-154/157.0
TLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLL
.. ..| |  |.   . |. .||..  |..  | .  ..||||| | .| |||. .|.....|... || .   .|| .|  ||  |.| ||
hiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
0038934 (Phosphotyrosine protein) phosphatases II 1063-1209 1.9e-16 55.7 In-house 35-187 (194) alignment 
Range on Protein: 1063-1209
Range on HMM: 35-187/194.0
VDELYLGSRIPASNLQLLKGEGITHILNC---AGMVCPNHFQDH--FVYKTLFISDGN--GEDISCLFYEILDFIQDAtKTNGKVYIHCHQGISRSSAFV
..|||  |     ..  |..........      .  |..|...   ..|  |..||.    .| . |....|.. .. ...|.|..||. |..|.  .|
ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlv

ILYLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLLKHLQHPSVKE
. ||.  ...| ..| .. . .|  . ||...  .|. . |.| |.  .|. .|
aaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlapekpe
0051429 (Phosphotyrosine protein) phosphatases II 1064-1201 6.2e-15 51.1 In-house 21-227 (272) alignment 
Range on Protein: 1064-1201
Range on HMM: 21-227/272.0
DE-LYLGSRI---PASNLQLLKGEGITHILNCAGMVCPNHFQ-----DHFVYKTLFISDGNGEDIS----------------------------------
.  ||....     | ... || .||..|..  . .  ....      .. |  | | |   ..|.                                  
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagear

-----------------CLFYEILDFIQDatktNGKVYIHCHQGISRSSAFVILYLMWiNKWS--------------FQQAHEFTKKRRYISNPNPGFTG
                   . |.|....|    .|.|..||. |..|.  .| |.|.    .|               ..| |  ...|  .......  
evmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLMYWNKFLLKH
.|. . . ||. 
flyeallellrs
0043336 (Phosphotyrosine protein) phosphatases II 1077-1198 3.6e-14 48.4 In-house 105-276 (278) alignment 
Range on Protein: 1077-1198
Range on HMM: 105-276/278.0
LQLLKGEGITHILNCAGMV---------------------------------------------CPNHFQ-DHFVYKTLFiSDGNGEDISCLFYEILDFI
 .... .|.|.|..  . |                                             ... ..  |. |.     .|  |..| |.  . ...
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavr

QDATKTNGKVYIHCHQGISRSSAFVILYLM-----WINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFL
.   . ||.|..||. |..|. .|..|||.      . ......| .. ...|. . ..| .  .| .. ...
ealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 1066-1198 8.3e-14 44.9 In-house 6-141 (145) alignment 
Range on Protein: 1066-1198
Range on HMM: 6-141/145.0
LYLGSRIPASNLQLLKGEGITHILNCAG---MVCPNHFQDHFVYKTLFISDGNGEDISCLFYEILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWI
|| || . |... .|.  ||. |.| |    . . .   ...    .  .| .  |.|  | |. |||.   .    |..||  |.||| .  . .||  
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

NKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFL
 . .. .|    . .|  . ||  |  .|.  .| |
cnmtlseaarqvrsnrllaypnvtflknllnlekql
subfamily_PTPMT1_pd Subfamily PTPMT1 1126-1181 8.2e-12 39.9 In-house 96-151 (171) alignment 
Range on Protein: 1126-1181
Range on HMM: 96-151/171.0
ILDFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKRRYIS
 ..||.. ...  .||.||. | .||.. |. |||  .|.| ..|... ||.| | 
gvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkii
0047943 (Phosphotyrosine protein) phosphatases II 1113-1194 1.4e-11 39.8 In-house 178-267 (273) alignment 
Range on Protein: 1113-1194
Range on HMM: 178-267/273.0
DGNGEDISCLFYEILDFIQDATK---TNGKVYIHCHQGISRSSAFVILYLM-----WINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYW
| .  .    . |.......| .    ||.|..||. |..|. .|..|.|.     . ..... .|  . ...|. . ..| .  .|...
dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyea
subfamily_MSG5_pd Subfamily MSG5 1128-1199 5.5e-11 35.8 In-house 90-161 (165) alignment 
Range on Protein: 1128-1199
Range on HMM: 90-161/165.0
DFIQDATKTNGKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKRRYISNPNPGFTGQLMYWNKFLL
  |  ||  . |. .||  |.|||..... |.|   . |...|..  | .    .|. |.  ||| |.  | 
riihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevals
0051299 (Phosphotyrosine protein) phosphatases II 1101-1185 6.1e-10 34.5 In-house 159-272 (288) alignment 
Range on Protein: 1101-1185
Range on HMM: 159-272/288.0
QDHFVYKTLFISDGN--------------------GEDISCLFYEILDFIQDATKT----NGKVYIHCHQGISRSSAFVILYLM-----WINKWSFQQAH
.|.... || ... .                      ..   . ..|||.... |     .| |..||. |..|. .|..|.|.       ..... .| 
lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

EFTKKRRYISNPNP
.. ...|. . ..|
krlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 1102-1186 2.1e-09 32.6 In-house 179-286 (308) alignment 
Range on Protein: 1102-1186
Range on HMM: 179-286/308.0
DHFVYKTLFISD-GNG-------------EDISCL--FYEILDFIQDATKT--NGKVYIHCHQGISRSSAFVILYLM-----WINKWSFQQAHEFTKKRR
|.... || ... |.|             .| ..   . ..|||.. . |.  .|....||. |..|. .|..|.|.     . .......|  . ...|
ddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR

YISNPNPG
. . ..| 
pgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 1123-1185 2.9e-09 32.2 In-house 184-260 (284) alignment 
Range on Protein: 1123-1185
Range on HMM: 184-260/284.0
FYEILDFIQDATKT------NGKVYIHCHQGISRSSAFVILYLMWIN--------KWSFQQAHEFTKKRRYISNPNP
.  .|.|.... .       .|.. .||. |..|. .|..|.|..          ......|  . ...|. .  ..
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0048567 (Phosphotyrosine protein) phosphatases II 1100-1178 3.5e-08 28.0 In-house 35-118 (157) alignment 
Range on Protein: 1100-1178
Range on HMM: 35-118/157.0
FQDHFVYKTLFISDGnG---EDISCLFYEILDFIQDATKTNGKVYIHCHQGI---SRSSAFVILYLMWINKWSFQQAHEFTKKRR
..| .|| ..|  .|       .  ... . .|... .........||. |    .|.  .. .||....... ..| .. .  |
iddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
subfamily_Laforin_pd Subfamily Laforin 1138-1177 1.8e-06 20.9 In-house 111-150 (183) alignment 
Range on Protein: 1138-1177
Range on HMM: 111-150/183.0
GKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKR
 .||.||  |. ||.| |  .|... .||...   |   .
hivyvhcnagvgrstaivcgflqyvlgwslakvqyfllak
Gelsolin Gelsolin repeat 1229-1301 3.3e-06 13.3 Pfam-A 7-76 (76) alignment 
Range on Protein: 1229-1301
Range on HMM: 7-76/76.0
VQTVSYLSLDARCCFILRVTDCIYIWSGEGcvgklgdLFLESAKLAISRFQRYE----NDSTNIIELRQGHEDDKFW
|  .|. ||..  ...|  .. ||.| |.|         .|  ..| .......    .  . .|   ||.| . |.
vvplsssslesgdvyLLdtgftiylWiGkg.......ssqeeknfaadlaaeldseerfplpelirevqgkeparFl
Gelsolin Gelsolin repeat 195-281 4e-06 13.0 Pfam-A 8-54 (76) alignment 
Range on Protein: 195-281
Range on HMM: 8-54/76.0
DLLHYKNYNQSECYIILHVFnsnqnnvnksyissprslnnilshdplfsyfdsnnkllhDLYTWNGKNSDSLSRAFCLSKALEFSkA
..| ... .   .|.... |                                       ..| |.||.|. . ..|. . | |.. .
vplsssslesgdvyLLdtgf.......................................tiylWiGkgssqeeknfaadlaaeld.s
subfamily_PTPDC1_pd Subfamily PTPDC1 1128-1178 4e-06 21.4 In-house 103-155 (182) alignment 
Range on Protein: 1128-1178
Range on HMM: 103-155/182.0
DFI--QDATKTNGKVYIHCHQGISRSSAFVILYLMWINKWSFQQAHEFTKKRR
| .   . . ..||| .||| |  |    .  ||.. .. . ..| .. ...|
divkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskr
PTPc_DSPc_SM00012 1125-1168 7.6e-06 21.4 In-house 21-70 (105) alignment 
Range on Protein: 1125-1168
Range on HMM: 21-70/105.0
EILDFIQDATKT------NGKVYIHCHQGISRSSAFVILYLMWINKWSFQ
.||.....  |       .. | .||. |..|.  || |.... . .. .
silellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket