Gene dupA in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP015_AA protein Get Run
DdisP015_AA_2128-2273 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 2129-2271 2.7e-75 244.9 In-house 1-154 (154) alignment 
Range on Protein: 2129-2271
Range on HMM: 1-154/154.0
DRPSKVASFMYISSFNPSMNKnMLINEYQITHIINC-TGSPNAFPDH---------FEYLHLQLHDQPHQDITQSLSLAFDFIRDAI--VHHGKVLICSD
||.||.|.|.|||||....|| .......|..|.|. .|..|.|.|.         .|||.|.|.|....||...|..||.||.|||  |...|||..||
drnskeaiflyissfdaalnk.ldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsd

KGVSRSSALAIGYFMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQRRN
||||||.||.|.|.||...||...|..|..|.||||.||.||..||....|....
kGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifekellf
subfamily_DSP1_pd Subfamily DSP1 2129-2269 3.3e-36 118.8 In-house 16-156 (163) alignment 
Range on Protein: 2129-2269
Range on HMM: 16-156/163.0
DrPSK-VASFMYISSFNPSMNKNMLINeYQITHIINCTG-SPNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALA
| |.. .  |.|. | . . |...| .  .||.|.|...  .|.|.|.||| .|.|.|.|..||.. .. . .|| ... ..|||||  . |.||||.| 
d.PvekildfLylGsetvasnleiLks.lgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlc

IGYFMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQR
. |.| .. .|. ||| .|.. |.|||||.||| || .. |. 
laylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
subfamily_DSP19_pd Subfamily DSP19 2133-2268 1.2e-33 110.7 In-house 14-149 (152) alignment 
Range on Protein: 2133-2268
Range on HMM: 14-149/152.0
KVASFMYISSFNPSMNKNMLiNEYQITHIINCT-GSPNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFM
.|   .|..| .  ..|..| .| .||||.| . | ||.||..|.||.... |.| .|... |. |.|||..|  ..| ||.  . |||||....|.|.|
eveprlylgsqdvaadkeil.kekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

DSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQ
 ....|. ||. |||. |  |.||.||..||... ..
kkeelsleealelvrearpcikPneGFikqLkeyeae
Pkinase Protein kinase domain 1731-2026 3.3e-31 98.3 Pfam-A 2-257 (260) alignment 
Range on Protein: 1731-2026
Range on HMM: 2-257/260.0
KDLKRVAKGAYGTVYKGTLGNDEGlEIAVKLMPVPKTIHDRCVL--YdiftEILIMDTFrSDSRGCHMFDYGVDGENYWIVMKSYKC-SLKEWrLKQTLP
. |... .|..|.|||..  ...  ..||| .  ... ..           |. |. .. . .  ......  . .....|.. ... .| .. ||.  .
elleklGsGsfGkVykakekktgk.kvAvKilkkeeekskkektalr....Elkilkkl.nHpnivkllevfeekdelylvleyveggdlfdl.lkkkgk

FleLLPLLLNIFTNVLQSVQFLGDHKINHFDIKCDNFLVHplKKGTIeedfwnqptndpnfavCLADWGEAKVYtQDVEGYTTRNRGTEFIKSPEMLTia
.      . .|....|.....| ...| | |.| .|.|..  .||..                ..||.| ||.. .  .. .|   ||.   .||.|   
l..seeeikkialqilegleylHsngiiHrDLKpeNiLld..ekgel................kiaDFGlakkl.eksseklttlvgtreYmAPEvll..

yasqktrenfdrrKKVGSNTASDVWSLGCLFYELLTGDFLFYDDDWVKFFIRVTQPGQELITPERKSKVANIPAILDYLDYVFIRDPFYRPTLRDLLTK
             |. .  ...||||||...||||||...|....  .   .. .  .. .  .....  . . . | .. .. .||  |.|....|..
.............kakeytkkvDvWslGvilyelltgklpfsgeseedqlelirkilkkkleedepkssskseelkdlikkllekdpakRltaeeilkh
0044763 (Phosphotyrosine protein) phosphatases II 2125-2272 1.8e-29 98.0 In-house 17-173 (178) alignment 
Range on Protein: 2125-2272
Range on HMM: 17-173/178.0
RFYMDRPSKVASFMYISSFNPSMNKNMLiNEYQITHIINCTGS--------PNAFPDH--FEYLHLQLHDQPHQDITQSLSLAFDFIRDAI-VHHGKVLI
|...  .|..  ..|..|..|......|  |. ||||.|.|.         .  .|.   ..|||. ..| . .|... .  ...||..|.  ..|.||.
rsdyinaseilpglylgslppaddlell.kelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlV

CSDKGVSRSSALAIGYFMDSRSISYFEAFILVRDCRYiISPNTGFVEQLCRWGKQRRNF
.   ||.|| .|.. | | ....|..||. ||| .|  |.|| |...||... .. .. 
HCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllke
subfamily_DSP10_pd Subfamily DSP10 2131-2268 9.4e-29 94.3 In-house 14-152 (159) alignment 
Range on Protein: 2131-2268
Range on HMM: 14-152/159.0
PSKVASFMYISSFNPSMNKNMlINEYQITHIINCTG-SPNAFPD-HFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIG
 |.| .|... | . . .... .....||...| |  .|| | . ...| .....|. .|.. |    |..|| .|  .  .||.    |.|||....|.
asqvlpfLflGsekdaadlda.ldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YFMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQ
| |  ...|  .|. .|...| ||||| .|. || .. |.
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
subfamily_DSP14_pd Subfamily DSP14 2132-2271 9.8e-28 91.1 In-house 8-146 (157) alignment 
Range on Protein: 2132-2271
Range on HMM: 8-146/157.0
SKVASFMYISsfNPSMNKNMLINEYQITHIINCT-GSPNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYF
|.... ...|    . ... |.....||.|||.|   ||   ...|.......|.|...... .  . | |...  ..||.|.    ||||| .|.. | 
sqitpsLfls..gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclayl

MDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQRRN
|  ...|  ||. ||...| ||.||.|| .|| .. |. ..
mkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkg
PTPc_motif_SM00404 2131-2267 9.9e-28 91.8 In-house 2-139 (140) alignment 
Range on Protein: 2131-2267
Range on HMM: 2-139/140.0
PSKVASFMYISSFNPSMnKNMLINEYQITHIINCTGSPN--AFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIG
||..   .|..| . .. .  |.....|||.||.| . .      .|..|...|.|.  ..... |. . |||..|.  .||||.    ||||| .|.| 
psrilphlylgskskaq.npallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YFMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGK
| |..|..|. ||. .|.. | |||||..||.||. . |
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
DSPc Dual specificity phosphatase, catalytic domain 2147-2267 6.2e-26 85.8 Pfam-A 10-132 (133) alignment 
Range on Protein: 2147-2267
Range on HMM: 10-132/133.0
MnkNMLINEYQITHIINCT-GSPN---AFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFMDSRSISYFEAF
.    |.....||..||.|   ||     . ..|||.....|.  ..|.. |. | .||..|.  ..|||.    |.||| .|.| | |.....|. ||.
s..lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAy

ILVRDCRYIISPNTGFVEQLCRWGK
 .|.. | .||||.||. ||. . .
efvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 2147-2267 6.2e-26 85.8 In-house 10-132 (133) alignment 
Range on Protein: 2147-2267
Range on HMM: 10-132/133.0
MnkNMLINEYQITHIINCT-GSPN---AFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFMDSRSISYFEAF
.    |.....||..||.|   ||     . ..|||.....|.  ..|.. |. | .||..|.  ..|||.    |.||| .|.| | |.....|. ||.
s..lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAy

ILVRDCRYIISPNTGFVEQLCRWGK
 .|.. | .||||.||. ||. . .
efvkerrskispnagflrqLleyer
subfamily_DSP15_pd Subfamily DSP15 2132-2269 3e-25 83.1 In-house 3-139 (151) alignment 
Range on Protein: 2132-2269
Range on HMM: 3-139/151.0
SKVASFMYISSFNPSMNKNMLiNEYQITHIINCTGSPNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFM
|||   .|.. |. | ....| .| .||||..   ... . ...||. ... | |...... .. . .|| .. .. ..||.    |||||  |.. |.|
skvlpglylgnfrdskdeelL.keknithilsvhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

DSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQR
   .... .|.  .. .| .  ||.|| .||  . |..
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyektk
subfamily_MKPLT_pd Subfamily MKPLT 2139-2266 4e-24 79.0 In-house 30-157 (164) alignment 
Range on Protein: 2139-2266
Range on HMM: 30-157/164.0
YISSFNPSMNKNMlINEYQITHIINCT-GSPNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFMDSRSIS
|    . . |... ... .||||.| . .  .|||  .||| ....|.... ... |  | .|. |||   |.||.   .|.||||. .. . . |.   
ylGnakhatnekv.lkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

YFEAFILVRDCRYIISPNTGFVEQLCRWG
. ||.  ... | |..|| ||. ||... 
lkeayeylkerrsivapnrGflkqlakfe
subfamily_MKPLV_pd Subfamily MKPLV 2139-2266 4e-24 79.0 In-house 30-157 (164) alignment 
Range on Protein: 2139-2266
Range on HMM: 30-157/164.0
YISSFNPSMNKNMlINEYQITHIINCT-GSPNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFMDSRSIS
|    . . |... ... .||||.| . .  .|||  .||| ....|.... ... |  | .|. |||   |.||.   .|.||||. .. . . |.   
ylGnakhatnekv.lkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwt

YFEAFILVRDCRYIISPNTGFVEQLCRWG
. ||.  ... | |..|| ||. ||... 
lkeayeylkerrsivapnrGflkqlakfe
0048076 (Phosphotyrosine protein) phosphatases II 2131-2268 8.7e-24 79.3 In-house 4-141 (145) alignment 
Range on Protein: 2131-2268
Range on HMM: 4-141/145.0
PSKVASFMYISSFNPSMNKNMLiNEYQITHIINC-TGSPNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGY
||..   .|..|.   ..  .|  ...||...|. .  .. .. ...||.| . | . .|... |  ...||..|. ..|.||..   ||.|. .|.. |
pseilpglylgslptaldlell.kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

FMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQ
 | ....|..||. ||| .| .. || |....|... ..
lmlllgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_Slingshot_pd Subfamily Slingshot 2128-2264 1.2e-23 77.4 In-house 16-152 (169) alignment 
Range on Protein: 2128-2264
Range on HMM: 16-152/169.0
MDRPSKVASFMYISSFNPSMNKNMLiNEYQITHIINCTGS-PNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALA
.|..||.  ..|. |   . | . | .| ....|.| |    | ||..||||.....|....|. .    ...||. |  .. |||.   .|||||..  
ldsaskifdhvylGsewnasnleel.kengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastv

IGYFMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCR
| | | . ..|. ||.  |.. | .| ||.||..||  
iayamkeyglsleealeyvkerrsvikPnkgflkqlee
subfamily_DSP6_pd Subfamily DSP6 2128-2268 3.4e-23 75.9 In-house 11-153 (158) alignment 
Range on Protein: 2128-2268
Range on HMM: 11-153/158.0
MDRPSKVASFMYISSFNPSMNKNMLiNEYQITHIINCTGS-PNAFPD--HFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSA
   | .. ...|. | . . | ..| ....| ...| |   ||.| .  ...||.. ..|. .|.... .  |..|| .|  .. |||.    |.||| .
aefpveilpllylGsakdasnlevl.kklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

LAIGYFMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQ
... |.| .. .|  .|. ||.. .  ||||  |..||  . ..
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
subfamily_DSP12_pd Subfamily DSP12 2133-2268 3.4e-23 76.7 In-house 4-142 (155) alignment 
Range on Protein: 2133-2268
Range on HMM: 4-142/155.0
KVASFMYISSFNPSMNKnMLINEYQITHIINCTGSP----NAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIG
..   .|... .. ...  | .|..|||..  .  .    .. . . .....|. |.|..|| . |  |.||| .|. ..|.||.    |||||... | 
rilpglylggleavqee.ellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YFMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQ
|.| .  .|  .|. ||.. .  |.||.||.|||  . | 
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekm
0048179 (Phosphotyrosine protein) phosphatases II 2131-2267 4.8e-23 76.9 In-house 4-142 (144) alignment 
Range on Protein: 2131-2267
Range on HMM: 4-142/144.0
PSKVASFMYISSFNPSMNKNMLiNEYQITHIINCTGSPNAFPDH---FEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAI
||.. . .|..|.  ...  .|  ...||..||.| .          ..|||| ..| .  |... |  ...||..|. ..|.||..   ||.|. .|..
pseilpglylgslptaldlell.kklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

GYFMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGK
 | |  . .|..||. ||| .|... || |....|....|
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 2135-2268 9.3e-23 74.4 In-house 12-146 (148) alignment 
Range on Protein: 2135-2268
Range on HMM: 12-146/148.0
ASFMYISSFNPSMNKNMlINEYQITHIINCTGS-PNAFPDH-FEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFMD
 .|... | .  .. .. ...  .|.|.|.| . .||. ..  ||||..|.|.|..|. .    . .|.| |  . ..||.    |||||||||. ...|
dafLFlGskksaadlea.lkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlid

SRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQ
 . .|  ||. ||.. |  . || ||..||  . ..
fkrvslkealalvkskrryvdpnlgfLkqLaeleqa
0041856 (Phosphotyrosine protein) phosphatases II 2130-2270 1.4e-22 75.6 In-house 18-173 (182) alignment 
Range on Protein: 2130-2270
Range on HMM: 18-173/182.0
RPSKVASFMYISSFNP--------------SMNKNMLINEyQITHIINCTgSPNAFPDHF-----EYLHLQLHDQPHQDitqsLSLAFDFIRDAIVHHGK
 ....    |..|. .               .. .|| .. .||.|.|.| ... .|...     .||.|.  | .  |    |. ..|||.... ..|.
dldyInanlylgslpatrfiatqgpllstvadflrmlkel.gittivnlt.eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VLICSDKGVSRSSALAIGYFMDSRSISYFEAFILVRDCRY--IISPNTGFVEQLCRWGKQRR
||.    ||.|. .|.. |.| ....|..||. ||| .|   .|.|| .|..||. . ....
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_DSP3_pd Subfamily DSP3 2133-2268 1.9e-22 73.6 In-house 13-156 (162) alignment 
Range on Protein: 2133-2268
Range on HMM: 13-156/162.0
KVASFMYISSFNPSMNKNMLiNEYQITHIINCTGS--------PNAFPD-HFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVH-HGKVLICSDKGVSRS
 |   .|..  . ...|. | ..  |||..|.. .        .. . | ...|| |...|.|. |. .  . |..||..|. . .||||. . .|||||
evypklyvgdeavakdkskL.kklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRs

SALAIGYFMDSRSISYFEAFILVRDCRYIiSPNTGFVEQLCRWGKQ
..|.. | | .|...  ||   ||. | |  ||.||..||.   ..
atlvlayLmirrkmtlveairtvrkkRei.lPneGFlkqLaeldee
subfamily_LRR-DSP_pd Subfamily LRR-DSP 2131-2267 3.2e-22 72.9 In-house 120-256 (263) alignment 
Range on Protein: 2131-2267
Range on HMM: 120-256/263.0
PSKVASFMYISSFNPSMNKNMLiNEYQITHI-INCTGSPNAFPDHFEYLHL-QLHDQPHQDITQSLSLAFDFIRDAiVHHGKVLICSDKGVSRSSALAIG
|...   ... . . ..||..| .. ..||| .  .     ||. | || . ...| .. || | .     || .   ..| ||.    ||||||.| | 
PdeiidklflGgldsannksil.kdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeG.rkkGGvlvhcraGvsrsstlvis

YFMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGK
|.|  ... . ||. ||   |  | ||.||..|| .. |
ylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
subfamily_STYX_pd Subfamily STYX 2149-2265 3.2e-22 72.4 In-house 31-153 (166) alignment 
Range on Protein: 2149-2265
Range on HMM: 31-153/166.0
KNMLINEYQITHIINCTGSPNA------FPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFMDSRSISYFEAF
|   ...  ||||.    ...|      |||.| || |.. |.. ..| . |    .|| |.. . ||||.  . |.|||.|| |.|.|..  . | |||
klevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreaf

ILVRDCRYIISPNTGFVEQLCRW
  |.. |. |.|| |||.||  .
ayvqerrfcinpnegfvsqlkey
subfamily_STYXL1_pd Subfamily STYXL1 2134-2268 1.1e-21 70.7 In-house 15-152 (157) alignment 
Range on Protein: 2134-2268
Range on HMM: 15-152/157.0
VASFMYISSFNPSMNKNmLINEYQITHIINCTGS----PNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGY
. ...|.  .. ..|.. . .. ..   .| .       .. .|  . ||....|... |. . |. | .|| .   .   ||. |.||.||| |..|.|
lPgklylGnykqaqnpa.ikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiay

FMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQ
.| |. |.. .|.  ...|.  . || .||||| .| ||
lmyskkitlkkaykylkkCkenvkPnrafveqlseWekq
0049772 (Phosphotyrosine protein) phosphatases II 2151-2269 3.7e-21 71.6 In-house 165-273 (314) alignment 
Range on Protein: 2151-2269
Range on HMM: 165-273/314.0
MLIneyqithiiNCTGSPNAFPDH-FEYLHLQLHDqPHQDITQSLSLAFDFIRDAiVHHGKVLICSDKGVSRSS-ALAIGYFMDSRSISYFEAFILVRDC
.|          ... .|. |... ..||.. . | ....... .  ...||..|   .|.||..   |..|.  .....| |  . .|. ||.  || .
llk.........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlk

RYiISPNTGFVEQLCRWGKQR
|. |.|| ||.|||... .. 
Rp.inpnpgfieqleqyefil
subfamily_DSP8_pd Subfamily DSP8 2130-2268 5.3e-20 65.6 In-house 14-153 (159) alignment 
Range on Protein: 2130-2268
Range on HMM: 14-153/159.0
RPSKVASFMYISSFNPSMNKNMLiNEYQITHIINCTGSPN--AFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAI
.| ..  ..|. | . ......| ... |....|   |     .  . ..|.. ..|. . .. . .  ...||  |  ..|.||.    | |||...||
gptrilknlylGsqkdvlseell.sklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

GYFMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQ
.| |   ..|. ||.  |.. |  ||||  |..||  . |.
ayimktlemsldeayrfvkekrptispnlnflgqLleyeke
0043147 (Phosphotyrosine protein) phosphatases II 2134-2273 3.5e-19 64.6 In-house 22-164 (172) alignment 
Range on Protein: 2134-2273
Range on HMM: 22-164/172.0
VASFMYISSFNPSMNKNMLiNEYQITHIINCTG----SPNAFPDHFEYLHLQLHDQPHQdITQSLSLAFDFIRD--AIVHHGKVLICSDKGVSRSSALAI
.  . .  ... ... .||  |..||||.|.|.     .. ..  ..||.|   |.. . ... |  ...||..  |.  .|.||.    ||.|. .|..
fiatqgplrntladfwrml.kelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlva

GYFMDsRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGKQRRNFK
 | |  ...|..||. |||..| ....| ..  .|. . |.....|
aylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllllk
0040439 (Phosphotyrosine protein) phosphatases II 2152-2265 1.7e-18 62.6 In-house 73-241 (249) alignment 
Range on Protein: 2152-2265
Range on HMM: 73-241/249.0
LINEYQITHIINCTGSPN--------------------------------------------AFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIV-
.. |..||.|...|                                                 .......||.| .| |.... .|.. ..|||. .   
mlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrka

-----HHGKVLICSDKGVSRSSALAIGYFM-----DSRSISYFEAFILVRDCRYIISPNTGFVEQLCRW
      .|.||. .  ||.|. .... | |       . ....||. |.|..|. . .| .. ..|...
leelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0045098 (Phosphotyrosine protein) phosphatases II 2127-2267 8.1e-18 60.2 In-house 18-269 (278) alignment 
Range on Protein: 2127-2267
Range on HMM: 18-269/278.0
YMDRPSKVASFMYISSFN-----------------------------------------PSMNKNMLInEYQITHIINC---------------------
 .  ||..  ..|.....                                          . . .||  |..||.|...                     
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlw.elgitvivmltelvelgrekcaqywpeggsl

--------------------------------TGSPNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIV--------------HHGKVLICSDKG
                                .. ....  |. ||.   |. |...|..|.  ...|||.|.               ..|.||.    |
tygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaG

VSRSSALAIGYFMDSR---SISYFEAFILVRDCRYI-ISPNTGFVEQLCRWGK
|.|. .|.. | | ..    ....||.  .| .| . . .| .. ..|...  
vgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefll
0046846 (Phosphotyrosine protein) phosphatases II 2146-2267 1.2e-17 59.7 In-house 36-170 (176) alignment 
Range on Protein: 2146-2267
Range on HMM: 36-170/176.0
SMNKNMLINEYQITHIINCTGS--------PNAFPD----HFEYLHLQLHDQPHQDItQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFMDS
 ..   .. |..||...|.|          || .|.    ...||||   |    |. . |  ...|||.|. ..|.||.    |..|. .|.. | . .
ladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel

-RSISYFEAFILVRDCRY-IISPNTGFVEQLCRWGK
 . .|..||. |||..|   . .. .....| .. .
ekglsveealalvreqRplgavqtpeQyrflyefel
0045450 (Phosphotyrosine protein) phosphatases II 2142-2265 1.3e-17 59.9 In-house 51-299 (307) alignment 
Range on Protein: 2142-2265
Range on HMM: 51-299/307.0
SFNPSMNKNM-----------------------------------------------------------------LINEYQITHIINCTGSPNA------
..  ...||                                                                  .. |...|.|...|..         
llpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekca

-----------------------FPDHFEYLHLQLHDQ-----------------PHQDITQSLSLAFDFIRDAIV------HHGKVLICSDKGVSRSSA
                         |.. ...| ..|                  |.... .|.. ..|||. .         .|.||. .  ||.|. .
qywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGt

LAIGYFMDSRS--------ISYFEAFILVRDCRYIISPNTGFVEQLCRW
... | | ..         ....||. |.|..|. . .| .. ..|...
fiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0049260 (Phosphotyrosine protein) phosphatases II 2145-2268 1.8e-16 55.6 In-house 22-148 (152) alignment 
Range on Protein: 2145-2268
Range on HMM: 22-148/152.0
PSMNKNMLiNEYQITHIINCTGSPN----AFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRD-AIVHHGKVLICSDKGVSRSSALAIGYFMDsRSISYF
 . ...||  |..||.|...|         .. ...||||.  | . .|..| |  ...||.  |.  .|.||.    ||.|. .|.. | |  . .|..
ladfwrml.kelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsle

EAFILVRDCRYIISPNTGFVEQLCRWGKQ
||. ||| .| .. || |. ..|  . |.
eavalvrekRpgavpnpgqlrflyefekl
0040438 (Phosphotyrosine protein) phosphatases II 2134-2265 1.2e-15 53.0 In-house 31-271 (317) alignment 
Range on Protein: 2134-2265
Range on HMM: 31-271/317.0
VASFMYISSFNPSMNKNML--------------------------------------------------------INEYQITHIINCTGSPNA-------
  . . ....  ...||                                                          . |...|.|.. | .          
kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaq

---------------------FPDHFEYLHLQLHDQ----------------PHQDITQSLSLAFDFIRDAIVH----HGKVLICSDKGVSRSSALAIGY
                       .......|.. |                 |.... .|..| .||.. .  .    .|.||. .  ||.|. .... |
YwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaay

FM-----DSRSISYFEAFILVRDCRYIISPNTGFVEQLCRW
 |       . ....||.  .| .|. . .. .. ..|...
lmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
Pkinase_Tyr Protein tyrosine kinase 1734-2023 1.8e-15 46.7 Pfam-A 5-255 (259) alignment 
Range on Protein: 1734-2023
Range on HMM: 5-255/259.0
KRVAKGAYGTVYKGTLG---NDEGLEIAVKLMpvpKTIHDRCVLYDIFTEILIMDTFrSDSRGCHMFDYGVDGENYWIVMKSYKCS-LKEwRLKQT-LPF
|....||.|.|..|||    ... ...||| .   |  ...    ....|. || .. . ..  ..    ...|...||..  .   |..  |...  . 
kklGeGafGeVvegtlkgekekkevkVavKtl...keeaeeeekeefleeakimkkl.khenivkllgvctkeepllivteyvegGdLlk.fLrkkekek

LELLPlLLNIFTNVLQSVQFLGDHKINHFDIKCDNFLVHPlkkgtieedfwnqptndpNFAVCLADWGEAKVYTQDvEGYTTRNRGTEFIK--SPEMLTI
|.|   ||.. ... . ...| ..|. | |. . | |..                   |  | ..| | |.  ..| . |.......  .|  .||.|. 
ltled.llsfalqiAkGmeyLeskklvHrdLaarNvLlee..................nkvvkisDfGLardiekd.dyykkkekaklpvkWmapEslke

AYasqktrenfdrrkkvgSNTASDVWSLGCLFYELLTGDFLFYDDDWVKFFIRVTQPGQELITPERKSKvanipAILDYLDYVFIRDPFYRPTLRDL
                   ...||||| | | .|..|     | .   . ...  . |..| .||  ..      . . .   . ..|  |||...|
kk................ftsksDvWsfGvllwEiftlgespypglsneevleklkegkrlekpencpe.....elyelmkqCweeepekRptfkel
0037934 (Phosphotyrosine protein) phosphatases II 2149-2265 1.4e-14 49.7 In-house 64-237 (243) alignment 
Range on Protein: 2149-2265
Range on HMM: 64-237/243.0
KNMLINEYQITHIINCTG----------------------------------------------SPNAFPDHFEYLHLQLHD----QPHQDITQSLSLAF
   .. |..||.|...|                                                .. .  .. |..|   |    . ..|. . |. . 
fwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevr

DFIRD-----AIVHHGKVLICSDKGVSRSSALAIGYFMDSR-SISYFEAFILVRDCRYI-ISPNTGFVEQLCRW
.||..     |. ..|.||.    ||.|. .|.. | | .. .....||. |.|..|   . .. .. ..| ..
efieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0036941 (Phosphotyrosine protein) phosphatases II 2152-2265 3.6e-14 48.2 In-house 97-272 (297) alignment 
Range on Protein: 2152-2265
Range on HMM: 97-272/297.0
LINEYQITHIINCTGSPNA------------------------------------------------FPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRD
.. |...|.|.. |                                                      .....  |.. .. |. .. .| .  .|||. 
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfiel

AIV------HHGKVLICSDKGVSRSSALAIGYFM--------DSRSISYFEAFILVRDCRYIISPNTGFVEQLCRW
.         .|.||. .  ||.|| .... . |          . ....||.  .|..|. . .. .. ..|...
vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
0051082 (Phosphotyrosine protein) phosphatases II 2133-2262 6.1e-13 44.1 In-house 10-146 (151) alignment 
Range on Protein: 2133-2262
Range on HMM: 10-146/151.0
KVASFMYISSFNPSMNKNMLiNEYQITHIINCTG------SPNAFPD-HFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVH-HGKVLICSDKGVSRSSA
 | ...|.|..  . . ..|  |..|..|.|...       |. .|.  .|.||....| | ... .|.  . .|.. .. . .|.||.    |..|. .
yvtgglyrsggpladflell.kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

LAIGYFMDsRSISYFEAFILVRDCRY-IISPNTGFVEQL
|.. | |  . .|..||.  .| .|  .. ||..|. ||
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfql
0036282 (Phosphotyrosine protein) phosphatases II 2135-2267 9.1e-13 43.7 In-house 16-167 (174) alignment 
Range on Protein: 2135-2267
Range on HMM: 16-167/174.0
ASFMYISSFNPSmnKNMLINEYQITHIINCTGSPN----------------AFPDHFEYLHLQLHDQPHQDITQsLSLAFDFIRDAIVH--HGKVLICSD
 .  .....  .     .. |..||...... .                    . ...||.|   |    |... |  ...|...|. .  .|.||.   
tprliagqgpla..fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCs

KGVSRSSALAIGYFMDSRSI-SYFEAFILVRDCR---YIISPNTGFVEQLCRWGK
 ||.|. .|.. | |  . . |. .|. ||| .|     . .. .. ..|  ..|
aGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0042113 (Phosphotyrosine protein) phosphatases II 2152-2265 2.1e-12 42.5 In-house 71-238 (245) alignment 
Range on Protein: 2152-2265
Range on HMM: 71-238/245.0
LINEYQITHIINCTGSPN--------------------------------------------AFPDHFEYLHLQLHDQPHQDITQSLSLAF---DFIRDA
.. |..||.|...|                                                  . ..| .|.. .. |..... .|.| .   .|.|.|
mlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrka

IV--HHGKVLICSDKGVSRSSALAIGYFM-----DSRSISYFEAFILVRDCRYIISPNTGFVEQLCRW
.    .|.||. .  ||.|. .... | |       . .| .||.  .|..|. . .. .. ..| ..
laedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
PTEN_1 2148-2264 8.1e-12 40.4 In-house 56-186 (196) alignment 
Range on Protein: 2148-2264
Range on HMM: 56-186/196.0
NKNMLINEYQ--ITHIINCTGSPN----------AFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAI--VHHGKVLICSDKGVSRSSALAIGYFMDS
. ..| | ..  ||...| .  ..          .|  ..||||.   | . ... . .  . .||  ..   ....||.    |..||  ... | | .
vaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmyk

RSISYFEAFILVRDCRYIISPNTGFVEQLCR
.  .. ||. |||..|  ..||... |.| .
gkltadeAlelvrekRppgapnspsqerlle
0039614 (Phosphotyrosine protein) phosphatases II 2151-2265 8.8e-12 40.5 In-house 119-284 (297) alignment 
Range on Protein: 2151-2265
Range on HMM: 119-284/297.0
MLINEYQITHIINCTGSPNA-------FPD---------------------------------HFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIV----
 .. |...|.|.. |            .|.                                  ... |.| .. |. .. .||.| ..|.. .      
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--HHGKVLICSDKGVSRSSALAIGYFM-----DSRSISYFEAFILVRDCRYIISPNTGFVEQLCRW
   .|.||. .  ||.|. .... | |       . ....||.  .| .|. . .. .. ..|...
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0043336 (Phosphotyrosine protein) phosphatases II 2136-2264 2.4e-11 39.1 In-house 35-271 (278) alignment 
Range on Protein: 2136-2264
Range on HMM: 35-271/278.0
SFMYISSFNPSMNKNML--------------------------------------------------------INEYQITHIINCTGSPN----------
  ..|. .  ...||                                                          . |...|.|.. |.             
dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYw

---------------------------------AFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIV----HHGKVLICSDKGVSRSSALAIGYFM-
                                   .  .. .|.. .. |....  |||| .||.....      .|.||. .  ||.|. .... | . 
pggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialylll

----DSRSISYFEAFILVRDCRYIISPNTGFVEQLCR
    . . ....||.  .| .|. . ..  . ..|..
eqlekeggvdleeavkelreqRpgavqtpsqyrflye
0047943 (Phosphotyrosine protein) phosphatases II 2153-2263 1.9e-10 36.1 In-house 97-265 (273) alignment 
Range on Protein: 2153-2263
Range on HMM: 97-265/273.0
INEYQITHIINCTGSPN-----------------------------------------------AFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAI
. |.....|.  |   .                                                ... ... |.. .. | ... .||.  ..||... 
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

V------HHGKVLICSDKGVSRSSALAIGYFM-----DSRSISYFEAFILVRDCRYIISPNTGFVEQLC
       ..|.|.. .  ||.|. .... . .       . ....||. |.|..|. . ..  . ..|.
kalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
subfamily_MSG5_pd Subfamily MSG5 2175-2267 2.3e-09 30.6 In-house 68-158 (165) alignment 
Range on Protein: 2175-2267
Range on HMM: 68-158/165.0
FEYLHLQLHDQphQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFMDSRSISYFEAFILVRDCRYIISPNTGFVEQLCRWGK
 .| |.. . .    |.. ||     |  |  .. |.|.  . |.|||..| . | |   ..|  .|. ...     |||. |.. ||  |. 
vkyyhiewehd..skivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewev
0051299 (Phosphotyrosine protein) phosphatases II 2153-2255 4.7e-09 31.6 In-house 112-271 (288) alignment 
Range on Protein: 2153-2255
Range on HMM: 112-271/288.0
INEYQITHIINCTGS------------------------------------------------PNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDA
. |.....|.  |.                                                 ..    .... |.. .. |.... .|..| .||.|..
vweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlv

IVH----HGKVLICSDKGVSRSSALAIGYFM-----DSRSISYFEAFILVRDCRYIISPN
. .    .| |.. .  ||.|. .... . .       . ....||.  .| .|. . ..
rkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
subfamily_PTPMT1_pd Subfamily PTPMT1 2153-2264 4.5e-07 24.5 In-house 54-163 (171) alignment 
Range on Protein: 2153-2264
Range on HMM: 54-163/171.0
INEYQITHIINCTGSPNAFpdHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFMDSRSISYFEAFILVRDCRYII
 .||..... |.| . .      |.|.|.  |  ..  ...|. . .||.. . .  .| .    | .||..|.. | | .. .|  ||   ....| ||
neeyelkalansteewkkl..gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkii

SPNTGFVEQLCR
  ..  ...| .
rlakkqwkalqe
0046845 (Phosphotyrosine protein) phosphatases II 2155-2251 5.5e-07 24.7 In-house 99-255 (284) alignment 
Range on Protein: 2155-2251
Range on HMM: 99-255/284.0
EYQITHIINCTGSPNA----------------------------------------------FPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVH-
|.....|.  |.  .                                                  ...  |.. .. |.... .|..  ..|.|..  . 
eqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

-----HGKVLICSDKGVSRSSALAIGYFMDSR--------SISYFEAFILVRDCRYI
     .|.... .  ||.|. .... . . ..         ....||.  .|..|. 
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg
OmpH Outer membrane protein (OmpH-like) 260-302 6.5e-07 17.4 Pfam-A 60-102 (158) alignment 
Range on Protein: 260-302
Range on HMM: 60-102/158.0
QQQKQNSQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQK
|....| |....|. ...........|...|. |...|| |..
qkeqknlqseraqlsaeeekakeeelqakeqelqayaqqlqae
0038934 (Phosphotyrosine protein) phosphatases II 2156-2269 7.6e-07 24.5 In-house 55-176 (194) alignment 
Range on Protein: 2156-2269
Range on HMM: 55-176/194.0
YQITHIINCTG-SPNAFPDHFEYLHLQLHDQPHQDIT--QSLSLAFDFIRDAIVHH-----GKVLICSDKGVSRSSALAIGYFMDSRSISYFEAFILVRD
......|. |  ..   |..|| . .. .. |  |     ||.. ..|.. . ...     |.|..    |..|.  |.. | . .. .|. ||  |.|.
vklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfre

CRYIISPNTGFVEQLCRWGKQR
.|  . || ...|.|... |. 
kRpgaipnqdyleallkrykel
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 2152-2270 8.8e-07 22.1 In-house 19-142 (145) alignment 
Range on Protein: 2152-2270
Range on HMM: 19-142/145.0
LINEYQITHIINCT-----GSPNAFPDHFEYLHLQLHDQPHQDITQSLSLAFDFIRDAIVHHGKVLICSDKGVSRSSALAIGYFMDSRSISYFEAFILVR
...|  |. |.| .      | ..  ...| | .  .|    |..| .    |||         |..    ||||| .... ..|   ...  ||   ||
tlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvr

DCRYIISPNTGFVEQLCRWGKQRR
  |    ||  |. .| .  || .
snrllaypnvtflknllnlekqlk