Gene mpl3 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily LRR-DSP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP018_AA protein Get Run
DdisP018_AA_639-769 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LRR-DSP_pd Subfamily LRR-DSP 514-776 1.9e-169 555.5 In-house 1-263 (263) alignment
Range on Protein: 514-776
Range on HMM: 1-263/263.0
SSNKLLSLPKDFAYLVPSRIKQSYSDIDIDEYDENINTCNNINSNNNDSNNSNNNNNNNNDNNNNCNKNNILEMINSTELEGGGLGCLKELNIRDNRELI
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ssnkllslpkdfaylvpsrikqsysdidideydenintcnninsnnndsnnsnnnnnnnndnnnncnknnileminsteleggglgclkelnirdnreli

SLPVEYKQVESLMTLVTSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDDARDAPQYDISQHFEQTNCFIESGRKSGGV
||||||||||||.|||.|.|.|||...||||||||||..||..||.||||||..|.||.|||.|||.||||..|....|||||||.||.|||.|||.|||
slpveykqveslitlvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGGv

LVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCTNI
|||||||.|||||||||||||.||..||.|.|||..|||.|||||||||||.|||.|||||||
lvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfctni

subfamily_DSP1_pd Subfamily DSP1 633-773 1.3e-42 139.7 In-house 17-158 (163) alignment
Range on Protein: 633-773
Range on HMM: 17-158/163.0
PSE-IIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSSTLVIS
|.| |.. ..||.  .| |  ||..||||.|| . .... .|...|.|...   .| |. |||..||.   ||.. .|..| ||.||.|||||||||.. 
PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklk.leDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla

YLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFC
|||| .|.....|.|.|...|. |.|| ||. |||.|| || .
ylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll

subfamily_DSP19_pd Subfamily DSP19 635-771 5.4e-42 137.7 In-house 14-150 (152) alignment
Range on Protein: 635-771
Range on HMM: 14-150/152.0
EIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKS-GGVLVHCRAGISRSSTLVISYLM
|..| ..||  |.|..  ||.. .|||||    . . .||| |.| ||.   | |. |........  |||..|.. | |||||.||.|||...||.|||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsie.ilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
| .......|..||...|| |.|| ||  || .|||.|
kkeelsleealelvrearpcikPneGFikqLkeyeael

0044763 (Phosphotyrosine protein) phosphatases II 630-772 1e-38 128.1 In-house 20-171 (178) alignment
Range on Protein: 630-772
Range on HMM: 20-171/178.0
TSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKT---------FKYYSIdDARDAPQYDISQHFEQTNCFIESG--RKSGGVLVHCR
   .|||.||..||.| .|.. . |. ||||||.   ...|..|.|.         ..|. |    | .  |...||...  |||.   .| | |||||.
yinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCs

AGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPqIQPNPGFKDQLLKYEAKLF
||..|| |||. ||||...... .|..||...|| |.||||.  ||...| .|.
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll

subfamily_DSP12_pd Subfamily DSP12 634-771 1.5e-37 123.4 In-house 3-143 (155) alignment
Range on Protein: 634-771
Range on HMM: 3-143/155.0
SEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFF-PKT-FKYYSIDDARDAPQYDISQHFEQTNCFIESGR-KSGGVLVHCRAGISRSSTLVIS
|.| ||..||||  ... . |..|.|||.|  |    | . .|.  ...   ...| |. || .|..... |||... . | ||||| ||.|||.|.|| 
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
||||.... ...|..||..|.|.|.|| || .||  .|.  
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg

PTPc_motif_SM00404 633-770 1.7e-37 123.5 In-house 2-140 (140) alignment
Range on Protein: 633-770
Range on HMM: 2-140/140.0
PSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEP-FFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSSTLVIS
||.| |...||....|.|...|. |||||.. ..  ..     . |.. .|.  .|  . ..|....... |||. .|.|| |||||.||.||| ||.| 
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK
|||.|. .. ..|...|...||.|.|| .|. ||..|| |
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk

subfamily_DSP10_pd Subfamily DSP10 631-771 1.5e-35 116.5 In-house 12-153 (159) alignment
Range on Protein: 631-771
Range on HMM: 12-153/159.0
SIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPK-TFKYYSIdDARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLV
   |...| .|||    |..  .|..|.||..|    ..  .| . ..||  | ...|. . ...|.||.   |||  ||.|  |||||.||||||.|.|
apasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkri.pvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvv

ISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
|.||||........| ..|..||| | || .|  |||..| .|
iaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel

subfamily_DSP14_pd Subfamily DSP14 634-776 1e-34 113.8 In-house 8-149 (157) alignment
Range on Protein: 634-776
Range on HMM: 8-149/157.0
SEIIPGIFLGgLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSSTLVISYL
|.| | .||.   .|..   |.  .||.|. .. .      | ...  .  ..|.|. ....||...   ||. .|.|| .|||| ||.||| .|.. ||
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvp.veDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclayl

MKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCTNI
|||.... ..|  ||.|.||.|.|| ||  || .|| ||. .. 
mkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkss

0048076 (Phosphotyrosine protein) phosphatases II 632-772 2.6e-34 113.3 In-house 3-143 (145) alignment
Range on Protein: 632-772
Range on HMM: 3-143/145.0
IPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIdDARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVIS
 ||||.||..||.| .|.. . |. ||||..|    ..| .... ..|. . .  | .  |.......   |||. .|.|  |||||.||..|. |||. 
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylyl.pwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
|||....... .|..||.|.||.. ||||.  .|...| .|.
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelell

subfamily_DSP15_pd Subfamily DSP15 634-769 5.1e-34 111.6 In-house 3-137 (151) alignment
Range on Protein: 634-769
Range on HMM: 3-137/151.0
SEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKtFKYYSIdDARDAPQYDISQHFEQTNCFIESGR-KSGGVLVHCRAGISRSSTLVISYL
|...||..||..  ....  |.   |||||    . ...... ..|  |  | |.|. ..|..|.... || . | | ..||||| ||.||| |||. ||
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkci.aasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA
|    . ...|.. .. .|   .|| ||| || .|| 
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek

subfamily_DSP3_pd Subfamily DSP3 634-771 1.3e-33 109.9 In-house 12-157 (162) alignment
Range on Protein: 634-771
Range on HMM: 12-157/162.0
SEIIPGIFLGGLDSANNAPILQTLGITHILLAI-G-----DCEP-FFP-KTFKYYSIDdARDAPQYDISQHFEQTNCFIESG--RKSGGVLVHCRAGISR
 |. |....|. ..|..   |..|||||.| |  |     | .. |.    .||. .. ..|.|. |.|..||..  ||..   .|.| |||||..|.||
devypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGle.vdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

SSTLVISYLMKYQRMTFKQAMDLVQSKRpQIQPNPGFKDQLLKYEAKL
|.|||. ||| ...|| ..|.  |..|| .|.|| ||  || ... .|
satlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeel

0048179 (Phosphotyrosine protein) phosphatases II 632-770 2.3e-33 110.3 In-house 3-143 (144) alignment
Range on Protein: 632-770
Range on HMM: 3-143/144.0
IPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTF--KYYSIdDARDAPQYDISQHFEQTNCFIESGRK-SGGVLVHCRAGISRSSTLV
 ||||.||..||.| .|.. . |. ||||...  . ..|| |.. .  .|. . .  | .  |........  |||. .. .| |||||.||..|. |||
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhl.pwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

ISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK
. ||||........|..||.|.||.. ||||.  .||.|| .
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl

subfamily_DSP6_pd Subfamily DSP6 630-771 1e-32 106.9 In-house 11-154 (158) alignment
Range on Protein: 630-771
Range on HMM: 11-154/158.0
TSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPK--TFKYYSIDdARDAPQYDISQHFEQTNCFIESGRK-SGGVLVHCRAGISRSST
...| ||.| ..||  ..|.|  .|. |.| ..|    . . .| .   .||. |  ..|  . .....| ..  ||. .|. . .||||| |||||| |
aefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqip.iedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

LVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
....||||.. .....| |||......| ||  | .|||..| .|
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl

subfamily_Slingshot_pd Subfamily Slingshot 632-771 1e-31 103.6 In-house 18-157 (169) alignment
Range on Protein: 632-771
Range on HMM: 18-157/169.0
IPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVIS
 .|.|   ..||    | |   |.  |...||    ... |||..|.|. |    | .. |. .....|  |||  .|.|  |||||. |.|||.. ||.
saskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnir.vydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
| ||  ......|.. |...|  |.||.||  || .||  |
yamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil

0049772 (Phosphotyrosine protein) phosphatases II 513-774 2.6e-31 104.9 In-house 28-276 (314) alignment
Range on Protein: 513-774
Range on HMM: 28-276/314.0
ISSNKLLSLPKDFAYLVPSRIKQSYSDIDidEYDeNINTCNNINSNNNDSNNSNNNNNNnndnnnncnKNNI-----------------------LEMI-
.| . | .|   .|.|.. | |..| ||    .| |    .. . .. |  |..  ..          .. |                       ..|. 
rslsvlpeltilvadlflnrdknryldil..pad.nrvilpglpvsgsdyinasyvdgf.........lkfIatqgpleitvvdfreepvlyyngwrmvl

--------------------------------NSTELEGGglgclkelnirdnrelislpveykqveslmtlvtsipseiipgiflgGLDSANNAPILQt
                                . .  ..|                                               .. .| . . |. 
rgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...............................................neptaadlellk.

lgithillaiG--DCEPFFPKT-FKYYSIdDARDaPQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSST-LVISYLMKYQRMTFKQAMDLVQSKRP
          .  .  ..|... .||. | .  | .. .....|..   |||. .| | |||||.||..|. | .|. ||||........|.. |..|||
..........eelydpelferlgikylri.pvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp

qIQPNPGFKDQLLKYEAKLFCT
 |.|||||  ||. || .| . 
.inpnpgfieqleqyefileal

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 631-769 3.1e-31 101.9 In-house 5-145 (148) alignment
Range on Protein: 631-769
Range on HMM: 5-145/148.0
SIPSEIIPG-IFLGGLDSANNAPILQTLGITHILLAIGDCEPFF-PKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSSTL
  |||| .. .|||   || ..  |. ||.|.|  |  ...  .  .. .|. .   .| |..|.|. ||.   |..  .. |. ||||.. |.|||| |
tfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhva.ldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssal

VISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA
.. .|....|.. |.|..||.|||. ..||.||  || ..| 
allwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq

DSPc Dual specificity phosphatase, catalytic domain 640-769 5.2e-31 102.3 Pfam-A 1-132 (133) alignment
Range on Protein: 640-769
Range on HMM: 1-132/133.0
IFLGGLDSANnAPILQTLGITHILLAIGDCEP---FFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVISYLMKY
..||.  .|.  ..|. ||||... ..  ..    . .. ..| .|   .|  . .||...|..  |||. ...|  |||||.|||||| ||.| ||||.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

QRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA
.... ..|...|...|..| || ||. |||.|| 
knlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 640-769 5.2e-31 102.3 In-house 1-132 (133) alignment
Range on Protein: 640-769
Range on HMM: 1-132/133.0
IFLGGLDSANnAPILQTLGITHILLAIGDCEP---FFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVISYLMKY
..||.  .|.  ..|. ||||... ..  ..    . .. ..| .|   .|  . .||...|..  |||. ...|  |||||.|||||| ||.| ||||.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

QRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA
.... ..|...|...|..| || ||. |||.|| 
knlslneAyefvkerrskispnagflrqLleyer

PTEN_1 629-773 2.8e-30 100.6 In-house 32-193 (196) alignment
Range on Protein: 629-773
Range on HMM: 32-193/196.0
VTSIP-----SEIIPGIFLGGLDSA-NNAPILQTLGITHILLAIGDCEP---------FFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRK---S
....|     .||..| ..| |... ..   |.  |||...    ..|          || . ..|....  .| .  ..|..|.  . |||. ..    
mgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfp.ieDhgapslselfdicksfiewllsdpng

GGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFC
. |||||.||..|| |.|..|||.....|...|..||..|||.. ||...  .||.|.|.|. 
nvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella

0045098 (Phosphotyrosine protein) phosphatases II 622-772 1.2e-29 99.0 In-house 11-272 (278) alignment
Range on Protein: 622-772
Range on HMM: 11-272/278.0
VESLMTLVTSIPSEIIPGIFLGGLD-----------------------------------------SANNAPILQTLGITHILLAI--------------
 |    |...||||| |...||.||                                          |..   |. ||||.|. .               
lefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

--------------------------------------GDCEPFFPKTFKYYSIDDArDAPQYDISQHFEQTNCFIESGR---------------KSGGV
                                       |.|... . ..|....|  ..| ..|...| .   ||.. .               ..| |
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdh.gvpslpilksflellefirealkllaslllsslllldsggpv

LVHCRAGISRSSTLVISYLMKYQ---RMTFKQAMDLVQSKRPQ-IQPNPGFKDQLLKYEAKLF
||||.||..|. |||. |||...   .... .| . ..|.||. ...|...  .| .....|.
lVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_MKPLT_pd Subfamily MKPLT 628-772 1.6e-29 96.6 In-house 16-161 (164) alignment
Range on Protein: 628-772
Range on HMM: 16-161/164.0
LVTSIPSEIIPG-IFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSS
 . . || ...  ..||  . |.|. .|. | ||||..   ..   |||...|  ..   | ..  .|...|... |. .  .||| |||||  | ||||
rikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvk.vedesdeqlssfleraakfladaidsGGrvlvhcvqGksrss

TLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
.  . .|.|... |.|.| . .. .|  ..|| ||  || |.|  ..
svtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelil

subfamily_MKPLV_pd Subfamily MKPLV 628-772 1.6e-29 96.6 In-house 16-161 (164) alignment
Range on Protein: 628-772
Range on HMM: 16-161/164.0
LVTSIPSEIIPG-IFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSS
 . . || ...  ..||  . |.|. .|. | ||||..   ..   |||...|  ..   | ..  .|...|... |. .  .||| |||||  | ||||
rikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvk.vedesdeqlssfleraakfladaidsGGrvlvhcvqGksrss

TLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
.  . .|.|... |.|.| . .. .|  ..|| ||  || |.|  ..
svtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelil

0043147 (Phosphotyrosine protein) phosphatases II 630-772 2.9e-29 97.4 In-house 16-161 (172) alignment
Range on Protein: 630-772
Range on HMM: 16-161/172.0
TSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGD---CEPFFPKTFKYYSIdDARDAPQYdISQHFEQTNCFIES---GRKSGGVLVHCRAGISR
. || ..|.. .... . | .   |..||||||. . .    .|....  ..|. .    | .   ........  ||..    ...| |||||.||..|
yyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylyl.pwpDhgvp.llellleflefidellalspggpvlVHCsaGvgR

SSTLVISYLMKyQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
. |||. |||. ..... .|..||..|||.. .||..  .|...| .|.
tgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll

0041856 (Phosphotyrosine protein) phosphatases II 632-772 5.1e-29 96.6 In-house 18-173 (182) alignment
Range on Protein: 632-772
Range on HMM: 18-173/182.0
IPSEIIPGIFLGGLDS--------------ANNAPILQTLGITHILLAIgdCEPFFPKT-------FKYYSIDDARDAPqydisqhFEQTNCFIESGRKS
 ...| ....||.| .              |.. . |. ||||.|. .   .|. .|.        ..|....|    .       ..... |||  ...
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd.......ldelldfieevlee

-GGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRP--QIQPNPGFKDQLLKYEAKLF
 | |||||.||..|. |||. ||||...... .|..||.|.||   |.|| .|  ||. .| .|.
ggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll

subfamily_STYX_pd Subfamily STYX 634-770 6.9e-29 94.1 In-house 13-156 (166) alignment
Range on Protein: 634-770
Range on HMM: 13-156/166.0
SEIIPGIFLGGLDSANN--APILQTLGITHILLAIGDC-----EPFFPKTFKYYSIDDArDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSS
 ||.||.|||   .| .   ..|.  |||||.    .       | ||..|.|  .| | |..  .| ... ..  ||..  ..|| ||||  ||||||.
qeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldva.dntveniirylptvkefiddslqkggkvlvhgnagisrsa

TLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK
.|||.|.|.   . ...|.  || .|  |.|| || .|| .||| 
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai

0049260 (Phosphotyrosine protein) phosphatases II 633-769 1e-28 95.3 In-house 8-147 (152) alignment
Range on Protein: 633-769
Range on HMM: 8-147/152.0
PSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFK--YYSIDDARDAPQYDISQHFEQTNCFIES--GRKSGGVLVHCRAGISRSSTLV
| |.|.....|. . |..   |..||||.|.    ..|  ..|. .   |      | . .|.||.... . |||    .|.| |||||.||..|. |||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

ISYLMKyQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA
. |||. .......|..||..|||.. ||||.  .|...| 
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek

subfamily_DSP8_pd Subfamily DSP8 629-774 1.6e-27 90.0 In-house 11-157 (159) alignment
Range on Protein: 629-774
Range on HMM: 11-157/159.0
VTSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDC-EPFFPKTFKYYSIdDARDAPQYDISQHFEQTNCFIESGRKS-GGVLVHCRAGISRSST
 .  | .|.. ..||    . .  .|. |||...| |   | .. . |  |.  .   .|  . .... |...  ||.  ... | ||||. ||||||.|
advgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrv.PvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsat

LVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCT
..|.|.||. .|.. .|   |..||| |.||  | .|||.|| .| ..
vaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkll

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 640-770 4.9e-25 81.7 In-house 10-151 (154) alignment
Range on Protein: 640-770
Range on HMM: 10-151/154.0
IFLGGLDSANNAPILQTLGITHILLA-IGDCEpFFPKT---------FKYYSIDdARDAPQYDISQHFEQTNCFIESGR---KSGGVLVHCRAGISRSST
....  |.| |   ||   |..||   ||  .  |..          ..|  ..   | ...|| ......  ||..     . ..||||. .|.|||..
lyissfdaalnkldlqlkniksilnvgiGinn.lftdensdindgfiieylnle.lfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

LVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK
|.|||||. ..... .|. |... |..|.|| || .|| ..| .
llisylmdklkislslalellkdsryiikPnqGflkqleifeke

0046846 (Phosphotyrosine protein) phosphatases II 631-771 8.4e-25 82.9 In-house 10-172 (176) alignment
Range on Protein: 631-771
Range on HMM: 10-172/176.0
SIPSEIIPGIFLGGLD----------SANNAPILQTLGITHILLAIGDCEPFFPKT-------------FKYYSIDDArdaPQYDIsQHFEQTNCFIESG
  ...|.....||..            |..   |. ||||...    . |  . |              .... ..|       |. .....   ||.. 
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDh...gvpdl.elllellefirea

RKSG-GVLVHCRAGISRSSTLVISYLMKY-QRMTFKQAMDLVQSKRP-QIQPNPGFKDQLLKYEAKL
.|.|  |||||.|||.|. |||. ||... . ..  .|..||...|| .. ..|..  .| ..| .|
lkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll

0040439 (Phosphotyrosine protein) phosphatases II 636-772 3.9e-24 81.1 In-house 32-246 (249) alignment
Range on Protein: 636-772
Range on HMM: 32-246/249.0
IIPGIFLGGLDSANNAPI------------------------LQTLGITHILLAIGDCEP----------------------------------------
|.|| ||..   |.  .                         |. ||||.|. .  ..|.                                        
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---FFPKTFKYYSIDDaRDAPQYDISQHFEQTNCFIESGRK-------SGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQP
    ........ |    | | ......||..  |||  ||       .| ||||| ||..|. |... |||     |........|..|..|.||.. .
tnlydgesrtvlhiqy.tdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavq

NPGFKDQLLKYEAKLF
||..  .|......|.
npeqyrflyeallell

0045450 (Phosphotyrosine protein) phosphatases II 652-772 5.3e-24 80.9 In-house 125-304 (307) alignment
Range on Protein: 652-772
Range on HMM: 125-304/307.0
PILQTLGITHILLAIGDCEPFFPKTFKYYSIDDAR--------------------------------------------DAPQYDISQHFEQTNCFIESG
  |. .|.|.|.   ...|  ..| ..|.. ..                                              . | ......||..  |||  
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

R-------KSGGVLVHCRAGISRSSTLVISYLMKYQR--------MTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
|       |.| |||||.||..|. |... |||..|.        ... .|..|....||.. .||..  .| .....|.
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 643-771 2.6e-23 75.7 In-house 9-141 (145) alignment
Range on Protein: 643-771
Range on HMM: 9-141/145.0
GGLDSANNAPILQTLGITHIL-LAIGDC---EPFFPKTFKYYSIdDARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVISYLMKYQR
|    ||. |.|| |||. |. .| |.    .    . ..   |  | |   ||.||||..   ||. |.. | ||.||| ||.||| |. ...||||  
gsalhandvptlqelgisrivnmaagslvasqelksesieilli.taedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycn

MTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
||. .|   |.|.| .  ||  |  .||. | .|
mtlseaarqvrsnrllaypnvtflknllnlekql

0037934 (Phosphotyrosine protein) phosphatases II 635-771 7e-23 76.9 In-house 41-241 (243) alignment
Range on Protein: 635-771
Range on HMM: 41-241/243.0
EIIPGIFLGGL--------DSANNAPILQTLGITHILLAIGDC-----------------------------------------------EPFFPKTFKY
.. |.......        | |..   |. ||||.|.    ..                                               ....   . |
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

YSIDDARDAP-QYDISQHFEQTNCFIES------GRKSGGVLVHCRAGISRSSTLVISYLMKYQ-RMTFKQAMDLVQSKRPQ-IQPNPGFKDQLLKYEAK
... |    .   |. ....... |||.        ..| |||||.||..|. ||.. |||... .... .|..|....||. . ..|..  .| .....
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle

L
|
l

0036282 (Phosphotyrosine protein) phosphatases II 634-769 9.1e-23 76.3 In-house 13-167 (174) alignment
Range on Protein: 634-769
Range on HMM: 13-167/174.0
SEIIPGIFLGGLDSAnNAPILQTLGITHILLAIGDCEPF--------------FPKTFKYYSIDDARDAPQYDISQhFEQTNCFIESGRK---SGGVLVH
|.| |....|.   | . . |. ||||...  .  .|.               . ..   |      |    |.|. ...  .|.|. ..   .| ||||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CRAGISRSSTLVISYLMKYQRM-TFKQAMDLVQSKR---PQIQPNPGFKDQLLKYEA
|.||..|. |||. |||... . .. .|.|||...|   |.. ..|..  .| ..| 
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek

0051082 (Phosphotyrosine protein) phosphatases II 634-767 1.3e-22 75.5 In-house 9-149 (151) alignment
Range on Protein: 634-767
Range on HMM: 9-149/151.0
SEIIPGIFLGGLDSANNAPILQTLGITHILLAIG-----DCEPFFPK---TFKYYSIDDARDAPqydISQHFEQTNCFIESGRK--SGGVLVHCRAGISR
| . .|....|  .| . . |..|||..|.   .      |  ..|.   ..... |.|  | .   ....|.. . |.|  ..  .| |||||.||..|
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpg...lplsfdavleflellldkkngpvlvHCsaGkgR

SSTLVISYLMKyQRMTFKQAMDLVQSKRP-QIQPNPGFKDQLLKY
. |||. |||. ..... .|.. ...|||  .||| .|  ||. .
TGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal

subfamily_STYXL1_pd Subfamily STYXL1 630-772 7e-22 71.3 In-house 8-154 (157) alignment
Range on Protein: 630-772
Range on HMM: 8-154/157.0
TSIPSEIIPG-IFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFK---YYSIdDARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRS
.. |.|..|| ..||    | |  | . | .   .    |.....  . .      | .  | .. |. .....   |||. .|.|  |||    |||||
ktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhi.avedeneadllerlkeavqfiekhkkegevvlvfsnkGisrs

STLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
 ...|.||| ....|.|.|.. ..  .. ..|| .| .|| ..| .|.
aaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll

0042113 (Phosphotyrosine protein) phosphatases II 635-771 8e-22 73.3 In-house 49-242 (245) alignment
Range on Protein: 635-771
Range on HMM: 49-242/245.0
EIIPGIFLGGLDSANNAP----ILQTLGITHILLAI------------------------------------------------GDCEPFFPKTFKYYSI
.| |......  .... .     |. ||||.|.                                                   || |...  .. |...
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

DdarDAPQYDISQHFEQTNCFIES---GRKSGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
.   | .  |.......   |...     ..| |||||.||..|. |... |||     |...... .|.. ..|.||.. ..|..  .| .....|
p...dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

0038934 (Phosphotyrosine protein) phosphatases II 671-768 1.5e-20 69.1 In-house 74-173 (194) alignment
Range on Protein: 671-768
Range on HMM: 74-173/194.0
PFFPKTFKYYSID--DARDAPQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYE
 |    ..|...   |   .|...| ..| .   .. .  ..| |.||| ||..|. |||..||.....|. ..|..|...||| . ||... ..|||. 
efekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkry





0040438 (Phosphotyrosine protein) phosphatases II 654-775 8.4e-20 66.7 In-house 106-279 (317) alignment
Range on Protein: 654-775
Range on HMM: 106-279/317.0
LQTLGITHILLAIGDCEPFFPKTFKYYSIDDARDA------------------------------------------PQYDISQHFEQTNCFIESGRK--
.. .|.|.|.     .|.  .| ..|.. ..                                              | ... .....   |.|  |.  
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

---SGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCTN
   .| ||||| ||..|. |... |||     |........|.. ....||.. ..|..  .| ....... ..
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

0039614 (Phosphotyrosine protein) phosphatases II 656-772 1.2e-18 63.1 In-house 123-289 (297) alignment
Range on Protein: 656-772
Range on HMM: 123-289/297.0
TLGITHILLAIGDCEP--------------------------------------------FFPKTFKYYSIDDARDAP-QYDISQHFEQTNCFIESGRKS
 .|.|.|.     .|                                             .. . | |... |    |   .. . .|. . .... .|.
eqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkg

GGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
| ||||| ||..|. |... |||     |........|.. ....||.. ..|..  .| .....|.
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

0036941 (Phosphotyrosine protein) phosphatases II 656-775 5e-18 60.9 In-house 100-280 (297) alignment
Range on Protein: 656-775
Range on HMM: 100-280/297.0
TLGITHILLAIGDCEPFFPKTFKYYSID----------------------------------------------DARDAPQYDISQHFEQTNCFIESGR-
 ...|.|.    . |  ..| ..|.. .                                                 . | ... .....   |||  | 
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

------KSGGVLVHCRAGISRSSTLVISYLM--------KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCTN
      ..| |||||.||..|| |... .||        |........|.  . ..||.. .....  .|  ....|. ..
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

0043336 (Phosphotyrosine protein) phosphatases II 657-770 6e-18 60.7 In-house 111-275 (278) alignment
Range on Protein: 657-770
Range on HMM: 111-275/278.0
LGITHILLA-----------------------------------------------IGDCEPFFPKTFKYYSIDdARDAPQyDISQHFEQTNCFIESGR-
||.|.|.                                                  || |...   . |...    ..|  ..|....  . ..|  . 
lgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpe.slsllldflkavrealed

KSGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK
..| |||||.||..|. |... ||.     |...... .|.. ....||.. ..| .  .| .... 
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

0051429 (Phosphotyrosine protein) phosphatases II 634-773 3e-17 58.6 In-house 17-226 (272) alignment
Range on Protein: 634-773
Range on HMM: 17-226/272.0
SEIIPG-IFLGGLD---SANNAPILQTLGITHILLAIGDCEPFFPKTFKYYsiddaR----------DAPQYDISQHF----------------------
....|| ....|     .|.. . |..|||..|.   ...|  . |...|                 |   ..|....                      
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw.....pgirylhlpilddsaptilygalrvtllseellldyilrelllt

--------------------------EQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKyQRMT--------------FKQAMDLVQSKRPQIQPN
                          |.   ..|  ...| |||||.||..|. |.|  .|.  ....                .|.. ....||.. ..
lllsagearevmhlhytdwpdhgvpqeallellellldggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqt

PGFKDQLLKYEAKLFC
...  .|......|..
eeqylflyeallellr

subfamily_PTPMT1_pd Subfamily PTPMT1 695-771 3.5e-15 50.9 In-house 91-168 (171) alignment
Range on Protein: 695-771
Range on HMM: 91-168/171.0
QHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
.. |..  |||. ...|  | |||.|| .||.|||..|||| .... ..|.. ...||..|. .    ..| .|| ||
eklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl

subfamily_MSG5_pd Subfamily MSG5 707-771 1.1e-14 47.9 In-house 96-160 (165) alignment
Range on Protein: 707-771
Range on HMM: 96-160/165.0
GRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
  |   .||||. |.|||..|...|.|||  .....| |...|.  .|.|. |.  ||...|. |
tskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval

0047943 (Phosphotyrosine protein) phosphatases II 667-764 3.5e-14 48.4 In-house 161-264 (273) alignment
Range on Protein: 667-764
Range on HMM: 161-264/273.0
GDCEPFFPKTFKYYSIDDARDA-PQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNPGF
|. |... . | |... |        .. . .|. . ..|. ...| |.|||.||..|. |... .|.     |........|. |..|.|| . ..| .
gtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq

KDQL
  .|
yrfl

LRR_8 Leucine rich repeat 439-496 1.9e-13 39.6 Pfam-A 2-61 (61) alignment
Range on Protein: 439-496
Range on HMM: 2-61/61.0
NLKYLSIKHNALEYLP-NSLSNLSQLISLDLSQNKLKTLPP-NFDDLINLRMVWLSYNQI
|||.| ...| |...| .|...|| | .|||| |.||...|  |..| .||.. ||.|..
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl

LRR_8 Leucine rich repeat 392-450 1.1e-12 37.1 Pfam-A 2-61 (61) alignment
Range on Protein: 392-450
Range on HMM: 2-61/61.0
SLTTVNLTRNKLSKLQTSVFIELPSLTSLILDRNFISSIPDDI-DQIKNLKYLSIKHNAL
.|....|..|.|... |..|  |..|..| | .| ..||.... .. ..|..|....| |
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl

0046845 (Phosphotyrosine protein) phosphatases II 668-758 6.4e-12 40.9 In-house 161-260 (284) alignment
Range on Protein: 668-758
Range on HMM: 161-260/284.0
DCEPFFPKTFKYYSIDDARDAP-QYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQ--------RMTFKQAMDLVQSKRPQIQPNP
. |... . | | |. |    |   |. . ... . ..|.  ..| ..|||.||..|. |... .|...|        .... .|.  . ..||.   ..
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl





LRR_4 Leucine Rich repeats (2 copies) 485-522 3.5e-11 32.4 Pfam-A 2-40 (44) alignment
Range on Protein: 485-522
Range on HMM: 2-40/44.0
NLRMVWLSYNQITSLPS-MRKLVNLVTFDISSNKLLSLP
||....||.|.|..||    .| || | ..|.|.. .|.
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls

0051299 (Phosphotyrosine protein) phosphatases II 667-758 7.6e-11 37.5 In-house 177-272 (288) alignment
Range on Protein: 667-758
Range on HMM: 177-272/288.0
GDCEPFFPKTFKYYSIDDARDAPqyDISQHFEQTNCFI---EsgRKSGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNP
|| |... . | |... |    .  .... ..  . ..   .   ..| |.|||.||..|. |... .|.     | ..... .|.  . ..||.. ..|
gdgesrtvthfhytnwpdhgvpd..spellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp





0050432 (Phosphotyrosine protein) phosphatases II 672-758 2.2e-10 35.8 In-house 153-285 (308) alignment
Range on Protein: 672-758
Range on HMM: 153-285/308.0
FFPKT--------------------------------------------FKYYSIDdARDAPQYdiSQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTL
..| .                                            | | .     ..|..   ... .   .... ...| ..|||.||..|. |.
YwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp.dhgvPps..peilldflelvrkslpggpivVHCsaGvGRtGtf

VISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNP
.. .|.     | ..... .|.  . ..||.  ..|
ialdllleqlekeggvdvfeavkklReqRpgmvqtp

0048567 (Phosphotyrosine protein) phosphatases II 700-767 1.8e-09 32.1 In-house 63-134 (157) alignment
Range on Protein: 700-767
Range on HMM: 63-134/157.0
TNCFIES-GRKSGGVLVHCRAGI---SRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKY
 | |...   ... . ||| ||    .|. ||. .||......|  .|.....  || ..| .     |..|
lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllsly

LRR_4 Leucine Rich repeats (2 copies) 438-478 1.9e-09 26.9 Pfam-A 1-41 (44) alignment
Range on Protein: 438-478
Range on HMM: 1-41/44.0
KNLKYLSIKHNALEYLPNSLSNLSQLISLDLSQNKLKTLPP
.||..|.. .| .. ||..|.||..| .|.|| |..  |..
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa

LRR_4 Leucine Rich repeats (2 copies) 391-431 1.9e-08 23.7 Pfam-A 1-40 (44) alignment
Range on Protein: 391-431
Range on HMM: 1-40/44.0
KSLTTVNLTRNKLSKLQTSvFIELPSLTSLILDRNFISSIP
..|....|..|....|  . .  ||.|..| |..| ||...
tnLevLdLsnNnIkdlppe.lanLpnLktLnLsnNpisdls

subfamily_CDC14_pd Subfamily CDC14 708-752 5.3e-08 27.1 In-house 261-305 (328) alignment
Range on Protein: 708-752
Range on HMM: 261-305/328.0
RKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRP
. .|.. |||.||. |  ||. .||||  |.| ..|.  ..  ||
kaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP

subfamily_PTPDC1_pd Subfamily PTPDC1 709-753 5.9e-08 27.3 In-house 113-157 (182) alignment
Range on Protein: 709-753
Range on HMM: 113-157/182.0
KSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQ
. | | ||| ||  |   |. .||.  .|.| ..|..||.||||.
qegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk

PTPc_DSPc_SM00012 677-746 6.2e-08 28.1 In-house 5-75 (105) alignment
Range on Protein: 677-746
Range on HMM: 5-75/105.0
FKYYSIDDArDAPQ--YDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDL
..|... |   .|.   .| ....... . .   .|. |.|||.||..|. |.|  ...  | .. .. .|.
yhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdi

LRR_9 Leucine-rich repeat 373-450 8.9e-07 16.5 Pfam-A 46-125 (175) alignment
Range on Protein: 373-450
Range on HMM: 46-125/175.0
ELTLSTNFFQIIPDLQLVKSLTTVNLTRNKLSKLQTSVFIELPSLTSLILDRNFISSIP--DDIDQIKNLKYLSIKHNAL
 . || |  . .  . |.. | |. .  |.. ..  ..   ||.|| |||  | .  .   |.. ..|.| |||.  | .
aidlsdneirkldgfpllrrlktllvnnnricrigegldqalpalteliltnnslvelgdldplaslksltylsllrnpv

subfamily_PTEN_pd Subfamily PTEN 677-753 8.9e-07 24.1 In-house 82-158 (184) alignment
Range on Protein: 677-753
Range on HMM: 82-158/184.0
FKYYSIDDARDAPQYDISQHFEQTNCFIESGRKSgGVLVHCRAGISRSSTLVISYLMKYQRMTFK-QAMDLVQSKRPQ
 . | .||   .|   ...  |. . ..|. .|   | |||.||  |. .|...||.|.. .. . .|..| ...| .
vavypfdDhnppplelleeivediekwleedkkn.vvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtk

subfamily_DSP23_pd Subfamily DSP23 676-753 9.1e-07 23.6 In-house 53-127 (148) alignment
Range on Protein: 676-753
Range on HMM: 53-127/148.0
TFKYYSIDDARdAPQYDISQHFEQtnCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQ
|..   |||    |  .  ..| .     |.  |.  | |||  |  |. |..  ||.| ....  .|.  |. .|| 
tlvrlriddyh.ppaleqvvefvr..vveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg

LRR_8 Leucine rich repeat 485-523 1.3e-06 17.7 Pfam-A 2-42 (61) alignment
Range on Protein: 485-523
Range on HMM: 2-42/61.0
NLRMVWLSYNQITSLP--SMRKLVNLVTFDISSNKLLSLPK
||. ..|| |.....|  |  .| || ..|.|.|.| |...
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksisp

subfamily_RNGTT_pd Subfamily RNGTT 685-753 1.3e-06 22.2 In-house 88-156 (189) alignment
Range on Protein: 685-753
Range on HMM: 88-156/189.0
ARDAPQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQ
 ..||. .  ..| .  .   . . .  . |||  |  |.  |..|||.. . .  ..|..| .. ||.
kgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRpp