Gene mpl3 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily LRR-DSP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP018_AA protein Get Run
DdisP018_AA_639-769 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LRR-DSP_pd Subfamily LRR-DSP 514-776 1.9e-169 555.5 In-house 1-263 (263) alignment 
Range on Protein: 514-776
Range on HMM: 1-263/263.0
SSNKLLSLPKDFAYLVPSRIKQSYSDIDIDEYDENINTCNNINSNNNDSNNSNNNNNNNNDNNNNCNKNNILEMINSTELEGGGLGCLKELNIRDNRELI
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ssnkllslpkdfaylvpsrikqsysdidideydenintcnninsnnndsnnsnnnnnnnndnnnncnknnileminsteleggglgclkelnirdnreli

SLPVEYKQVESLMTLVTSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDDARDAPQYDISQHFEQTNCFIESGRKSGGV
||||||||||||.|||.|.|.|||...||||||||||..||..||.||||||..|.||.|||.|||.||||..|....|||||||.||.|||.|||.|||
slpveykqveslitlvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGGv

LVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCTNI
|||||||.|||||||||||||.||..||.|.|||..|||.|||||||||||.|||.|||||||
lvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfctni
subfamily_DSP1_pd Subfamily DSP1 633-773 1.3e-42 139.7 In-house 17-158 (163) alignment 
Range on Protein: 633-773
Range on HMM: 17-158/163.0
PSE-IIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSSTLVIS
|.| |.. ..||.  .| |  ||..||||.|| . .... .|...|.|...   .| |. |||..||.   ||.. .|..| ||.||.|||||||||.. 
PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklk.leDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla

YLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFC
|||| .|.....|.|.|...|. |.|| ||. |||.|| || .
ylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll
subfamily_DSP19_pd Subfamily DSP19 635-771 5.4e-42 137.7 In-house 14-150 (152) alignment 
Range on Protein: 635-771
Range on HMM: 14-150/152.0
EIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKS-GGVLVHCRAGISRSSTLVISYLM
|..| ..||  |.|..  ||.. .|||||    . . .||| |.| ||.   | |. |........  |||..|.. | |||||.||.|||...||.|||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsie.ilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylm

KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
| .......|..||...|| |.|| ||  || .|||.|
kkeelsleealelvrearpcikPneGFikqLkeyeael
0044763 (Phosphotyrosine protein) phosphatases II 630-772 1e-38 128.1 In-house 20-171 (178) alignment 
Range on Protein: 630-772
Range on HMM: 20-171/178.0
TSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKT---------FKYYSIdDARDAPQYDISQHFEQTNCFIESG--RKSGGVLVHCR
   .|||.||..||.| .|.. . |. ||||||.   ...|..|.|.         ..|. |    | .  |...||...  |||.   .| | |||||.
yinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCs

AGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPqIQPNPGFKDQLLKYEAKLF
||..|| |||. ||||...... .|..||...|| |.||||.  ||...| .|.
aGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_DSP12_pd Subfamily DSP12 634-771 1.5e-37 123.4 In-house 3-143 (155) alignment 
Range on Protein: 634-771
Range on HMM: 3-143/155.0
SEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFF-PKT-FKYYSIDDARDAPQYDISQHFEQTNCFIESGR-KSGGVLVHCRAGISRSSTLVIS
|.| ||..||||  ... . |..|.|||.|  |    | . .|.  ...   ...| |. || .|..... |||... . | ||||| ||.|||.|.|| 
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
||||.... ...|..||..|.|.|.|| || .||  .|.  
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
PTPc_motif_SM00404 633-770 1.7e-37 123.5 In-house 2-140 (140) alignment 
Range on Protein: 633-770
Range on HMM: 2-140/140.0
PSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEP-FFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSSTLVIS
||.| |...||....|.|...|. |||||.. ..  ..     . |.. .|.  .|  . ..|....... |||. .|.|| |||||.||.||| ||.| 
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK
|||.|. .. ..|...|...||.|.|| .|. ||..|| |
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
subfamily_DSP10_pd Subfamily DSP10 631-771 1.5e-35 116.5 In-house 12-153 (159) alignment 
Range on Protein: 631-771
Range on HMM: 12-153/159.0
SIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPK-TFKYYSIdDARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLV
   |...| .|||    |..  .|..|.||..|    ..  .| . ..||  | ...|. . ...|.||.   |||  ||.|  |||||.||||||.|.|
apasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkri.pvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvv

ISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
|.||||........| ..|..||| | || .|  |||..| .|
iaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel
subfamily_DSP14_pd Subfamily DSP14 634-776 1e-34 113.8 In-house 8-149 (157) alignment 
Range on Protein: 634-776
Range on HMM: 8-149/157.0
SEIIPGIFLGgLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSSTLVISYL
|.| | .||.   .|..   |.  .||.|. .. .      | ...  .  ..|.|. ....||...   ||. .|.|| .|||| ||.||| .|.. ||
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvp.veDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclayl

MKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCTNI
|||.... ..|  ||.|.||.|.|| ||  || .|| ||. .. 
mkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkss
0048076 (Phosphotyrosine protein) phosphatases II 632-772 2.6e-34 113.3 In-house 3-143 (145) alignment 
Range on Protein: 632-772
Range on HMM: 3-143/145.0
IPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIdDARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVIS
 ||||.||..||.| .|.. . |. ||||..|    ..| .... ..|. . .  | .  |.......   |||. .|.|  |||||.||..|. |||. 
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylyl.pwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

YLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
|||....... .|..||.|.||.. ||||.  .|...| .|.
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefelell
subfamily_DSP15_pd Subfamily DSP15 634-769 5.1e-34 111.6 In-house 3-137 (151) alignment 
Range on Protein: 634-769
Range on HMM: 3-137/151.0
SEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKtFKYYSIdDARDAPQYDISQHFEQTNCFIESGR-KSGGVLVHCRAGISRSSTLVISYL
|...||..||..  ....  |.   |||||    . ...... ..|  |  | |.|. ..|..|.... || . | | ..||||| ||.||| |||. ||
skvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkci.aasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA
|    . ...|.. .. .|   .|| ||| || .|| 
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek
subfamily_DSP3_pd Subfamily DSP3 634-771 1.3e-33 109.9 In-house 12-157 (162) alignment 
Range on Protein: 634-771
Range on HMM: 12-157/162.0
SEIIPGIFLGGLDSANNAPILQTLGITHILLAI-G-----DCEP-FFP-KTFKYYSIDdARDAPQYDISQHFEQTNCFIESG--RKSGGVLVHCRAGISR
 |. |....|. ..|..   |..|||||.| |  |     | .. |.    .||. .. ..|.|. |.|..||..  ||..   .|.| |||||..|.||
devypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGle.vdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

SSTLVISYLMKYQRMTFKQAMDLVQSKRpQIQPNPGFKDQLLKYEAKL
|.|||. ||| ...|| ..|.  |..|| .|.|| ||  || ... .|
satlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeel
0048179 (Phosphotyrosine protein) phosphatases II 632-770 2.3e-33 110.3 In-house 3-143 (144) alignment 
Range on Protein: 632-770
Range on HMM: 3-143/144.0
IPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTF--KYYSIdDARDAPQYDISQHFEQTNCFIESGRK-SGGVLVHCRAGISRSSTLV
 ||||.||..||.| .|.. . |. ||||...  . ..|| |.. .  .|. . .  | .  |........  |||. .. .| |||||.||..|. |||
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhl.pwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

ISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK
. ||||........|..||.|.||.. ||||.  .||.|| .
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_DSP6_pd Subfamily DSP6 630-771 1e-32 106.9 In-house 11-154 (158) alignment 
Range on Protein: 630-771
Range on HMM: 11-154/158.0
TSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPK--TFKYYSIDdARDAPQYDISQHFEQTNCFIESGRK-SGGVLVHCRAGISRSST
...| ||.| ..||  ..|.|  .|. |.| ..|    . . .| .   .||. |  ..|  . .....| ..  ||. .|. . .||||| |||||| |
aefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqip.iedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

LVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
....||||.. .....| |||......| ||  | .|||..| .|
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
subfamily_Slingshot_pd Subfamily Slingshot 632-771 1e-31 103.6 In-house 18-157 (169) alignment 
Range on Protein: 632-771
Range on HMM: 18-157/169.0
IPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVIS
 .|.|   ..||    | |   |.  |...||    ... |||..|.|. |    | .. |. .....|  |||  .|.|  |||||. |.|||.. ||.
saskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnir.vydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
| ||  ......|.. |...|  |.||.||  || .||  |
yamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil
0049772 (Phosphotyrosine protein) phosphatases II 513-774 2.6e-31 104.9 In-house 28-276 (314) alignment 
Range on Protein: 513-774
Range on HMM: 28-276/314.0
ISSNKLLSLPKDFAYLVPSRIKQSYSDIDidEYDeNINTCNNINSNNNDSNNSNNNNNNnndnnnncnKNNI-----------------------LEMI-
.| . | .|   .|.|.. | |..| ||    .| |    .. . .. |  |..  ..          .. |                       ..|. 
rslsvlpeltilvadlflnrdknryldil..pad.nrvilpglpvsgsdyinasyvdgf.........lkfIatqgpleitvvdfreepvlyyngwrmvl

--------------------------------NSTELEGGglgclkelnirdnrelislpveykqveslmtlvtsipseiipgiflgGLDSANNAPILQt
                                . .  ..|                                               .. .| . . |. 
rgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...............................................neptaadlellk.

lgithillaiG--DCEPFFPKT-FKYYSIdDARDaPQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSST-LVISYLMKYQRMTFKQAMDLVQSKRP
          .  .  ..|... .||. | .  | .. .....|..   |||. .| | |||||.||..|. | .|. ||||........|.. |..|||
..........eelydpelferlgikylri.pvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp

qIQPNPGFKDQLLKYEAKLFCT
 |.|||||  ||. || .| . 
.inpnpgfieqleqyefileal
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 631-769 3.1e-31 101.9 In-house 5-145 (148) alignment 
Range on Protein: 631-769
Range on HMM: 5-145/148.0
SIPSEIIPG-IFLGGLDSANNAPILQTLGITHILLAIGDCEPFF-PKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSSTL
  |||| .. .|||   || ..  |. ||.|.|  |  ...  .  .. .|. .   .| |..|.|. ||.   |..  .. |. ||||.. |.|||| |
tfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhva.ldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssal

VISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA
.. .|....|.. |.|..||.|||. ..||.||  || ..| 
allwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
DSPc Dual specificity phosphatase, catalytic domain 640-769 5.2e-31 102.3 Pfam-A 1-132 (133) alignment 
Range on Protein: 640-769
Range on HMM: 1-132/133.0
IFLGGLDSANnAPILQTLGITHILLAIGDCEP---FFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVISYLMKY
..||.  .|.  ..|. ||||... ..  ..    . .. ..| .|   .|  . .||...|..  |||. ...|  |||||.|||||| ||.| ||||.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

QRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA
.... ..|...|...|..| || ||. |||.|| 
knlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 640-769 5.2e-31 102.3 In-house 1-132 (133) alignment 
Range on Protein: 640-769
Range on HMM: 1-132/133.0
IFLGGLDSANnAPILQTLGITHILLAIGDCEP---FFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVISYLMKY
..||.  .|.  ..|. ||||... ..  ..    . .. ..| .|   .|  . .||...|..  |||. ...|  |||||.|||||| ||.| ||||.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmkt

QRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA
.... ..|...|...|..| || ||. |||.|| 
knlslneAyefvkerrskispnagflrqLleyer
PTEN_1 629-773 2.8e-30 100.6 In-house 32-193 (196) alignment 
Range on Protein: 629-773
Range on HMM: 32-193/196.0
VTSIP-----SEIIPGIFLGGLDSA-NNAPILQTLGITHILLAIGDCEP---------FFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRK---S
....|     .||..| ..| |... ..   |.  |||...    ..|          || . ..|....  .| .  ..|..|.  . |||. ..    
mgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfp.ieDhgapslselfdicksfiewllsdpng

GGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFC
. |||||.||..|| |.|..|||.....|...|..||..|||.. ||...  .||.|.|.|. 
nvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
0045098 (Phosphotyrosine protein) phosphatases II 622-772 1.2e-29 99.0 In-house 11-272 (278) alignment 
Range on Protein: 622-772
Range on HMM: 11-272/278.0
VESLMTLVTSIPSEIIPGIFLGGLD-----------------------------------------SANNAPILQTLGITHILLAI--------------
 |    |...||||| |...||.||                                          |..   |. ||||.|. .               
lefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

--------------------------------------GDCEPFFPKTFKYYSIDDArDAPQYDISQHFEQTNCFIESGR---------------KSGGV
                                       |.|... . ..|....|  ..| ..|...| .   ||.. .               ..| |
peggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdh.gvpslpilksflellefirealkllaslllsslllldsggpv

LVHCRAGISRSSTLVISYLMKYQ---RMTFKQAMDLVQSKRPQ-IQPNPGFKDQLLKYEAKLF
||||.||..|. |||. |||...   .... .| . ..|.||. ...|...  .| .....|.
lVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_MKPLT_pd Subfamily MKPLT 628-772 1.6e-29 96.6 In-house 16-161 (164) alignment 
Range on Protein: 628-772
Range on HMM: 16-161/164.0
LVTSIPSEIIPG-IFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSS
 . . || ...  ..||  . |.|. .|. | ||||..   ..   |||...|  ..   | ..  .|...|... |. .  .||| |||||  | ||||
rikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvk.vedesdeqlssfleraakfladaidsGGrvlvhcvqGksrss

TLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
.  . .|.|... |.|.| . .. .|  ..|| ||  || |.|  ..
svtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_MKPLV_pd Subfamily MKPLV 628-772 1.6e-29 96.6 In-house 16-161 (164) alignment 
Range on Protein: 628-772
Range on HMM: 16-161/164.0
LVTSIPSEIIPG-IFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFKYYSIDdARDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSS
 . . || ...  ..||  . |.|. .|. | ||||..   ..   |||...|  ..   | ..  .|...|... |. .  .||| |||||  | ||||
rikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvk.vedesdeqlssfleraakfladaidsGGrvlvhcvqGksrss

TLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
.  . .|.|... |.|.| . .. .|  ..|| ||  || |.|  ..
svtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelil
0043147 (Phosphotyrosine protein) phosphatases II 630-772 2.9e-29 97.4 In-house 16-161 (172) alignment 
Range on Protein: 630-772
Range on HMM: 16-161/172.0
TSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGD---CEPFFPKTFKYYSIdDARDAPQYdISQHFEQTNCFIES---GRKSGGVLVHCRAGISR
. || ..|.. .... . | .   |..||||||. . .    .|....  ..|. .    | .   ........  ||..    ...| |||||.||..|
yyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylyl.pwpDhgvp.llellleflefidellalspggpvlVHCsaGvgR

SSTLVISYLMKyQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
. |||. |||. ..... .|..||..|||.. .||..  .|...| .|.
tgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklll
0041856 (Phosphotyrosine protein) phosphatases II 632-772 5.1e-29 96.6 In-house 18-173 (182) alignment 
Range on Protein: 632-772
Range on HMM: 18-173/182.0
IPSEIIPGIFLGGLDS--------------ANNAPILQTLGITHILLAIgdCEPFFPKT-------FKYYSIDDARDAPqydisqhFEQTNCFIESGRKS
 ...| ....||.| .              |.. . |. ||||.|. .   .|. .|.        ..|....|    .       ..... |||  ...
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd.......ldelldfieevlee

-GGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRP--QIQPNPGFKDQLLKYEAKLF
 | |||||.||..|. |||. ||||...... .|..||.|.||   |.|| .|  ||. .| .|.
ggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_STYX_pd Subfamily STYX 634-770 6.9e-29 94.1 In-house 13-156 (166) alignment 
Range on Protein: 634-770
Range on HMM: 13-156/166.0
SEIIPGIFLGGLDSANN--APILQTLGITHILLAIGDC-----EPFFPKTFKYYSIDDArDAPQYDISQHFEQTNCFIESGRKSGG-VLVHCRAGISRSS
 ||.||.|||   .| .   ..|.  |||||.    .       | ||..|.|  .| | |..  .| ... ..  ||..  ..|| ||||  ||||||.
qeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldva.dntveniirylptvkefiddslqkggkvlvhgnagisrsa

TLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK
.|||.|.|.   . ...|.  || .|  |.|| || .|| .||| 
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai
0049260 (Phosphotyrosine protein) phosphatases II 633-769 1e-28 95.3 In-house 8-147 (152) alignment 
Range on Protein: 633-769
Range on HMM: 8-147/152.0
PSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFK--YYSIDDARDAPQYDISQHFEQTNCFIES--GRKSGGVLVHCRAGISRSSTLV
| |.|.....|. . |..   |..||||.|.    ..|  ..|. .   |      | . .|.||.... . |||    .|.| |||||.||..|. |||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

ISYLMKyQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEA
. |||. .......|..||..|||.. ||||.  .|...| 
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefek
subfamily_DSP8_pd Subfamily DSP8 629-774 1.6e-27 90.0 In-house 11-157 (159) alignment 
Range on Protein: 629-774
Range on HMM: 11-157/159.0
VTSIPSEIIPGIFLGGLDSANNAPILQTLGITHILLAIGDC-EPFFPKTFKYYSIdDARDAPQYDISQHFEQTNCFIESGRKS-GGVLVHCRAGISRSST
 .  | .|.. ..||    . .  .|. |||...| |   | .. . |  |.  .   .|  . .... |...  ||.  ... | ||||. ||||||.|
advgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrv.PvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsat

LVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCT
..|.|.||. .|.. .|   |..||| |.||  | .|||.|| .| ..
vaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkll
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 640-770 4.9e-25 81.7 In-house 10-151 (154) alignment 
Range on Protein: 640-770
Range on HMM: 10-151/154.0
IFLGGLDSANNAPILQTLGITHILLA-IGDCEpFFPKT---------FKYYSIDdARDAPQYDISQHFEQTNCFIESGR---KSGGVLVHCRAGISRSST
....  |.| |   ||   |..||   ||  .  |..          ..|  ..   | ...|| ......  ||..     . ..||||. .|.|||..
lyissfdaalnkldlqlkniksilnvgiGinn.lftdensdindgfiieylnle.lfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

LVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK
|.|||||. ..... .|. |... |..|.|| || .|| ..| .
llisylmdklkislslalellkdsryiikPnqGflkqleifeke
0046846 (Phosphotyrosine protein) phosphatases II 631-771 8.4e-25 82.9 In-house 10-172 (176) alignment 
Range on Protein: 631-771
Range on HMM: 10-172/176.0
SIPSEIIPGIFLGGLD----------SANNAPILQTLGITHILLAIGDCEPFFPKT-------------FKYYSIDDArdaPQYDIsQHFEQTNCFIESG
  ...|.....||..            |..   |. ||||...    . |  . |              .... ..|       |. .....   ||.. 
ldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDh...gvpdl.elllellefirea

RKSG-GVLVHCRAGISRSSTLVISYLMKY-QRMTFKQAMDLVQSKRP-QIQPNPGFKDQLLKYEAKL
.|.|  |||||.|||.|. |||. ||... . ..  .|..||...|| .. ..|..  .| ..| .|
lkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0040439 (Phosphotyrosine protein) phosphatases II 636-772 3.9e-24 81.1 In-house 32-246 (249) alignment 
Range on Protein: 636-772
Range on HMM: 32-246/249.0
IIPGIFLGGLDSANNAPI------------------------LQTLGITHILLAIGDCEP----------------------------------------
|.|| ||..   |.  .                         |. ||||.|. .  ..|.                                        
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---FFPKTFKYYSIDDaRDAPQYDISQHFEQTNCFIESGRK-------SGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQP
    ........ |    | | ......||..  |||  ||       .| ||||| ||..|. |... |||     |........|..|..|.||.. .
tnlydgesrtvlhiqy.tdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavq

NPGFKDQLLKYEAKLF
||..  .|......|.
npeqyrflyeallell
0045450 (Phosphotyrosine protein) phosphatases II 652-772 5.3e-24 80.9 In-house 125-304 (307) alignment 
Range on Protein: 652-772
Range on HMM: 125-304/307.0
PILQTLGITHILLAIGDCEPFFPKTFKYYSIDDAR--------------------------------------------DAPQYDISQHFEQTNCFIESG
  |. .|.|.|.   ...|  ..| ..|.. ..                                              . | ......||..  |||  
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

R-------KSGGVLVHCRAGISRSSTLVISYLMKYQR--------MTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
|       |.| |||||.||..|. |... |||..|.        ... .|..|....||.. .||..  .| .....|.
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 643-771 2.6e-23 75.7 In-house 9-141 (145) alignment 
Range on Protein: 643-771
Range on HMM: 9-141/145.0
GGLDSANNAPILQTLGITHIL-LAIGDC---EPFFPKTFKYYSIdDARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVISYLMKYQR
|    ||. |.|| |||. |. .| |.    .    . ..   |  | |   ||.||||..   ||. |.. | ||.||| ||.||| |. ...||||  
gsalhandvptlqelgisrivnmaagslvasqelksesieilli.taedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycn

MTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
||. .|   |.|.| .  ||  |  .||. | .|
mtlseaarqvrsnrllaypnvtflknllnlekql
0037934 (Phosphotyrosine protein) phosphatases II 635-771 7e-23 76.9 In-house 41-241 (243) alignment 
Range on Protein: 635-771
Range on HMM: 41-241/243.0
EIIPGIFLGGL--------DSANNAPILQTLGITHILLAIGDC-----------------------------------------------EPFFPKTFKY
.. |.......        | |..   |. ||||.|.    ..                                               ....   . |
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

YSIDDARDAP-QYDISQHFEQTNCFIES------GRKSGGVLVHCRAGISRSSTLVISYLMKYQ-RMTFKQAMDLVQSKRPQ-IQPNPGFKDQLLKYEAK
... |    .   |. ....... |||.        ..| |||||.||..|. ||.. |||... .... .|..|....||. . ..|..  .| .....
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle

L
|
l
0036282 (Phosphotyrosine protein) phosphatases II 634-769 9.1e-23 76.3 In-house 13-167 (174) alignment 
Range on Protein: 634-769
Range on HMM: 13-167/174.0
SEIIPGIFLGGLDSAnNAPILQTLGITHILLAIGDCEPF--------------FPKTFKYYSIDDARDAPQYDISQhFEQTNCFIESGRK---SGGVLVH
|.| |....|.   | . . |. ||||...  .  .|.               . ..   |      |    |.|. ...  .|.|. ..   .| ||||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CRAGISRSSTLVISYLMKYQRM-TFKQAMDLVQSKR---PQIQPNPGFKDQLLKYEA
|.||..|. |||. |||... . .. .|.|||...|   |.. ..|..  .| ..| 
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0051082 (Phosphotyrosine protein) phosphatases II 634-767 1.3e-22 75.5 In-house 9-149 (151) alignment 
Range on Protein: 634-767
Range on HMM: 9-149/151.0
SEIIPGIFLGGLDSANNAPILQTLGITHILLAIG-----DCEPFFPK---TFKYYSIDDARDAPqydISQHFEQTNCFIESGRK--SGGVLVHCRAGISR
| . .|....|  .| . . |..|||..|.   .      |  ..|.   ..... |.|  | .   ....|.. . |.|  ..  .| |||||.||..|
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpg...lplsfdavleflellldkkngpvlvHCsaGkgR

SSTLVISYLMKyQRMTFKQAMDLVQSKRP-QIQPNPGFKDQLLKY
. |||. |||. ..... .|.. ...|||  .||| .|  ||. .
TGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_STYXL1_pd Subfamily STYXL1 630-772 7e-22 71.3 In-house 8-154 (157) alignment 
Range on Protein: 630-772
Range on HMM: 8-154/157.0
TSIPSEIIPG-IFLGGLDSANNAPILQTLGITHILLAIGDCEPFFPKTFK---YYSIdDARDAPQYDISQHFEQTNCFIESGRKSG-GVLVHCRAGISRS
.. |.|..|| ..||    | |  | . | .   .    |.....  . .      | .  | .. |. .....   |||. .|.|  |||    |||||
ktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhi.avedeneadllerlkeavqfiekhkkegevvlvfsnkGisrs

STLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
 ...|.||| ....|.|.|.. ..  .. ..|| .| .|| ..| .|.
aaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
0042113 (Phosphotyrosine protein) phosphatases II 635-771 8e-22 73.3 In-house 49-242 (245) alignment 
Range on Protein: 635-771
Range on HMM: 49-242/245.0
EIIPGIFLGGLDSANNAP----ILQTLGITHILLAI------------------------------------------------GDCEPFFPKTFKYYSI
.| |......  .... .     |. ||||.|.                                                   || |...  .. |...
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

DdarDAPQYDISQHFEQTNCFIES---GRKSGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
.   | .  |.......   |...     ..| |||||.||..|. |... |||     |...... .|.. ..|.||.. ..|..  .| .....|
p...dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0038934 (Phosphotyrosine protein) phosphatases II 671-768 1.5e-20 69.1 In-house 74-173 (194) alignment 
Range on Protein: 671-768
Range on HMM: 74-173/194.0
PFFPKTFKYYSID--DARDAPQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYE
 |    ..|...   |   .|...| ..| .   .. .  ..| |.||| ||..|. |||..||.....|. ..|..|...||| . ||... ..|||. 
efekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkry
0040438 (Phosphotyrosine protein) phosphatases II 654-775 8.4e-20 66.7 In-house 106-279 (317) alignment 
Range on Protein: 654-775
Range on HMM: 106-279/317.0
LQTLGITHILLAIGDCEPFFPKTFKYYSIDDARDA------------------------------------------PQYDISQHFEQTNCFIESGRK--
.. .|.|.|.     .|.  .| ..|.. ..                                              | ... .....   |.|  |.  
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

---SGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCTN
   .| ||||| ||..|. |... |||     |........|.. ....||.. ..|..  .| ....... ..
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0039614 (Phosphotyrosine protein) phosphatases II 656-772 1.2e-18 63.1 In-house 123-289 (297) alignment 
Range on Protein: 656-772
Range on HMM: 123-289/297.0
TLGITHILLAIGDCEP--------------------------------------------FFPKTFKYYSIDDARDAP-QYDISQHFEQTNCFIESGRKS
 .|.|.|.     .|                                             .. . | |... |    |   .. . .|. . .... .|.
eqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkg

GGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLF
| ||||| ||..|. |... |||     |........|.. ....||.. ..|..  .| .....|.
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0036941 (Phosphotyrosine protein) phosphatases II 656-775 5e-18 60.9 In-house 100-280 (297) alignment 
Range on Protein: 656-775
Range on HMM: 100-280/297.0
TLGITHILLAIGDCEPFFPKTFKYYSID----------------------------------------------DARDAPQYDISQHFEQTNCFIESGR-
 ...|.|.    . |  ..| ..|.. .                                                 . | ... .....   |||  | 
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

------KSGGVLVHCRAGISRSSTLVISYLM--------KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKLFCTN
      ..| |||||.||..|| |... .||        |........|.  . ..||.. .....  .|  ....|. ..
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0043336 (Phosphotyrosine protein) phosphatases II 657-770 6e-18 60.7 In-house 111-275 (278) alignment 
Range on Protein: 657-770
Range on HMM: 111-275/278.0
LGITHILLA-----------------------------------------------IGDCEPFFPKTFKYYSIDdARDAPQyDISQHFEQTNCFIESGR-
||.|.|.                                                  || |...   . |...    ..|  ..|....  . ..|  . 
lgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpe.slsllldflkavrealed

KSGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAK
..| |||||.||..|. |... ||.     |...... .|.. ....||.. ..| .  .| .... 
sngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0051429 (Phosphotyrosine protein) phosphatases II 634-773 3e-17 58.6 In-house 17-226 (272) alignment 
Range on Protein: 634-773
Range on HMM: 17-226/272.0
SEIIPG-IFLGGLD---SANNAPILQTLGITHILLAIGDCEPFFPKTFKYYsiddaR----------DAPQYDISQHF----------------------
....|| ....|     .|.. . |..|||..|.   ...|  . |...|                 |   ..|....                      
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw.....pgirylhlpilddsaptilygalrvtllseellldyilrelllt

--------------------------EQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKyQRMT--------------FKQAMDLVQSKRPQIQPN
                          |.   ..|  ...| |||||.||..|. |.|  .|.  ....                .|.. ....||.. ..
lllsagearevmhlhytdwpdhgvpqeallellellldggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqt

PGFKDQLLKYEAKLFC
...  .|......|..
eeqylflyeallellr
subfamily_PTPMT1_pd Subfamily PTPMT1 695-771 3.5e-15 50.9 In-house 91-168 (171) alignment 
Range on Protein: 695-771
Range on HMM: 91-168/171.0
QHFEQTNCFIESGRKSG-GVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
.. |..  |||. ...|  | |||.|| .||.|||..|||| .... ..|.. ...||..|. .    ..| .|| ||
eklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekl
subfamily_MSG5_pd Subfamily MSG5 707-771 1.1e-14 47.9 In-house 96-160 (165) alignment 
Range on Protein: 707-771
Range on HMM: 96-160/165.0
GRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKYEAKL
  |   .||||. |.|||..|...|.|||  .....| |...|.  .|.|. |.  ||...|. |
tskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval
0047943 (Phosphotyrosine protein) phosphatases II 667-764 3.5e-14 48.4 In-house 161-264 (273) alignment 
Range on Protein: 667-764
Range on HMM: 161-264/273.0
GDCEPFFPKTFKYYSIDDARDA-PQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNPGF
|. |... . | |... |        .. . .|. . ..|. ...| |.|||.||..|. |... .|.     |........|. |..|.|| . ..| .
gtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq

KDQL
  .|
yrfl
LRR_8 Leucine rich repeat 439-496 1.9e-13 39.6 Pfam-A 2-61 (61) alignment 
Range on Protein: 439-496
Range on HMM: 2-61/61.0
NLKYLSIKHNALEYLP-NSLSNLSQLISLDLSQNKLKTLPP-NFDDLINLRMVWLSYNQI
|||.| ...| |...| .|...|| | .|||| |.||...|  |..| .||.. ||.|..
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
LRR_8 Leucine rich repeat 392-450 1.1e-12 37.1 Pfam-A 2-61 (61) alignment 
Range on Protein: 392-450
Range on HMM: 2-61/61.0
SLTTVNLTRNKLSKLQTSVFIELPSLTSLILDRNFISSIPDDI-DQIKNLKYLSIKHNAL
.|....|..|.|... |..|  |..|..| | .| ..||.... .. ..|..|....| |
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl
0046845 (Phosphotyrosine protein) phosphatases II 668-758 6.4e-12 40.9 In-house 161-260 (284) alignment 
Range on Protein: 668-758
Range on HMM: 161-260/284.0
DCEPFFPKTFKYYSIDDARDAP-QYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQ--------RMTFKQAMDLVQSKRPQIQPNP
. |... . | | |. |    |   |. . ... . ..|.  ..| ..|||.||..|. |... .|...|        .... .|.  . ..||.   ..
tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
LRR_4 Leucine Rich repeats (2 copies) 485-522 3.5e-11 32.4 Pfam-A 2-40 (44) alignment 
Range on Protein: 485-522
Range on HMM: 2-40/44.0
NLRMVWLSYNQITSLPS-MRKLVNLVTFDISSNKLLSLP
||....||.|.|..||    .| || | ..|.|.. .|.
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls
0051299 (Phosphotyrosine protein) phosphatases II 667-758 7.6e-11 37.5 In-house 177-272 (288) alignment 
Range on Protein: 667-758
Range on HMM: 177-272/288.0
GDCEPFFPKTFKYYSIDDARDAPqyDISQHFEQTNCFI---EsgRKSGGVLVHCRAGISRSSTLVISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNP
|| |... . | |... |    .  .... ..  . ..   .   ..| |.|||.||..|. |... .|.     | ..... .|.  . ..||.. ..|
gdgesrtvthfhytnwpdhgvpd..spellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0050432 (Phosphotyrosine protein) phosphatases II 672-758 2.2e-10 35.8 In-house 153-285 (308) alignment 
Range on Protein: 672-758
Range on HMM: 153-285/308.0
FFPKT--------------------------------------------FKYYSIDdARDAPQYdiSQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTL
..| .                                            | | .     ..|..   ... .   .... ...| ..|||.||..|. |.
YwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp.dhgvPps..peilldflelvrkslpggpivVHCsaGvGRtGtf

VISYLM-----KYQRMTFKQAMDLVQSKRPQIQPNP
.. .|.     | ..... .|.  . ..||.  ..|
ialdllleqlekeggvdvfeavkklReqRpgmvqtp
0048567 (Phosphotyrosine protein) phosphatases II 700-767 1.8e-09 32.1 In-house 63-134 (157) alignment 
Range on Protein: 700-767
Range on HMM: 63-134/157.0
TNCFIES-GRKSGGVLVHCRAGI---SRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQIQPNPGFKDQLLKY
 | |...   ... . ||| ||    .|. ||. .||......|  .|.....  || ..| .     |..|
lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllsly
LRR_4 Leucine Rich repeats (2 copies) 438-478 1.9e-09 26.9 Pfam-A 1-41 (44) alignment 
Range on Protein: 438-478
Range on HMM: 1-41/44.0
KNLKYLSIKHNALEYLPNSLSNLSQLISLDLSQNKLKTLPP
.||..|.. .| .. ||..|.||..| .|.|| |..  |..
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa
LRR_4 Leucine Rich repeats (2 copies) 391-431 1.9e-08 23.7 Pfam-A 1-40 (44) alignment 
Range on Protein: 391-431
Range on HMM: 1-40/44.0
KSLTTVNLTRNKLSKLQTSvFIELPSLTSLILDRNFISSIP
..|....|..|....|  . .  ||.|..| |..| ||...
tnLevLdLsnNnIkdlppe.lanLpnLktLnLsnNpisdls
subfamily_CDC14_pd Subfamily CDC14 708-752 5.3e-08 27.1 In-house 261-305 (328) alignment 
Range on Protein: 708-752
Range on HMM: 261-305/328.0
RKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRP
. .|.. |||.||. |  ||. .||||  |.| ..|.  ..  ||
kaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrP
subfamily_PTPDC1_pd Subfamily PTPDC1 709-753 5.9e-08 27.3 In-house 113-157 (182) alignment 
Range on Protein: 709-753
Range on HMM: 113-157/182.0
KSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQ
. | | ||| ||  |   |. .||.  .|.| ..|..||.||||.
qegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk
PTPc_DSPc_SM00012 677-746 6.2e-08 28.1 In-house 5-75 (105) alignment 
Range on Protein: 677-746
Range on HMM: 5-75/105.0
FKYYSIDDArDAPQ--YDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDL
..|... |   .|.   .| ....... . .   .|. |.|||.||..|. |.|  ...  | .. .. .|.
yhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdi
LRR_9 Leucine-rich repeat 373-450 8.9e-07 16.5 Pfam-A 46-125 (175) alignment 
Range on Protein: 373-450
Range on HMM: 46-125/175.0
ELTLSTNFFQIIPDLQLVKSLTTVNLTRNKLSKLQTSVFIELPSLTSLILDRNFISSIP--DDIDQIKNLKYLSIKHNAL
 . || |  . .  . |.. | |. .  |.. ..  ..   ||.|| |||  | .  .   |.. ..|.| |||.  | .
aidlsdneirkldgfpllrrlktllvnnnricrigegldqalpalteliltnnslvelgdldplaslksltylsllrnpv
subfamily_PTEN_pd Subfamily PTEN 677-753 8.9e-07 24.1 In-house 82-158 (184) alignment 
Range on Protein: 677-753
Range on HMM: 82-158/184.0
FKYYSIDDARDAPQYDISQHFEQTNCFIESGRKSgGVLVHCRAGISRSSTLVISYLMKYQRMTFK-QAMDLVQSKRPQ
 . | .||   .|   ...  |. . ..|. .|   | |||.||  |. .|...||.|.. .. . .|..| ...| .
vavypfdDhnppplelleeivediekwleedkkn.vvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtk
subfamily_DSP23_pd Subfamily DSP23 676-753 9.1e-07 23.6 In-house 53-127 (148) alignment 
Range on Protein: 676-753
Range on HMM: 53-127/148.0
TFKYYSIDDARdAPQYDISQHFEQtnCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQ
|..   |||    |  .  ..| .     |.  |.  | |||  |  |. |..  ||.| ....  .|.  |. .|| 
tlvrlriddyh.ppaleqvvefvr..vveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpg
LRR_8 Leucine rich repeat 485-523 1.3e-06 17.7 Pfam-A 2-42 (61) alignment 
Range on Protein: 485-523
Range on HMM: 2-42/61.0
NLRMVWLSYNQITSLP--SMRKLVNLVTFDISSNKLLSLPK
||. ..|| |.....|  |  .| || ..|.|.|.| |...
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksisp
subfamily_RNGTT_pd Subfamily RNGTT 685-753 1.3e-06 22.2 In-house 88-156 (189) alignment 
Range on Protein: 685-753
Range on HMM: 88-156/189.0
ARDAPQYDISQHFEQTNCFIESGRKSGGVLVHCRAGISRSSTLVISYLMKYQRMTFKQAMDLVQSKRPQ
 ..||. .  ..| .  .   . . .  . |||  |  |.  |..|||.. . .  ..|..| .. ||.
kgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRpp