Gene DDB_G0272662 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP019_AA protein Get Run
DdisP019_AA_9-157 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PRL_pd Subfamily PRL 9-157 2.8e-66 216.2 In-house 2-150 (151) alignment
Range on Protein: 9-157
Range on HMM: 2-150/151.0
ETIIESSTHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDASLFE--GVKIHELCFKDGNVPPKDIIERWLEILKQAFIENGKQktTVGIHCIA
|..||.....|...|.||..|...|.. .||... ..||.||..||.. .|  |.....|.|.||.|||....|.|||.||..| |..|.  ||..||.|
eveieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepks..tvavhcva

GLGRTPLLVCIALIEDGMKPLQAVEFVRSKRKNAINSPQIKFLKEYKASKK
||||.|.||..||||.|||. .||||.|.||..|||| |.|||..|||.||
GlGraPvlvalalieaGmkyedavefirekrrgainskqlkflekykakkk

0038934 (Phosphotyrosine protein) phosphatases II 16-152 1.7e-30 101.5 In-house 17-169 (194) alignment
Range on Protein: 16-152
Range on HMM: 17-169/194.0
THKFILFDEPTEETI----------------PYFKDLMKKNSCINIVRCCEINYDASLFEG--VKIHELCFKD-GNVPPKDIIERWLEILKQAFIENgkQ
| .|| |. |.....                 |.|.| .|. ..  ... |  ||...||.  .....| |.| |.||. .|. |.|..... . |.  .
tgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflned..p

KTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRKNAInsPQIKFLKEY
. .|..|| ||||||..||. .||.  ||.. .|....|.||..||  |....|...
ggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai..pnqdyleal

0043147 (Phosphotyrosine protein) phosphatases II 15-152 5.1e-29 96.6 In-house 18-156 (172) alignment
Range on Protein: 15-152
Range on HMM: 18-156/172.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDASLFE--GVKIHELCFKDGNVPPKDIIERWLEILKQAFieNGKQKTTVGIHCIAGLGRTP
 ...|| .  |. .|.. | ...|.. .  ||...|  ||..|.|  |.... | . |..||. ......||......  . ... .| .|| ||.|||.
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidell..alspggpvlVHCsaGvgRtg

LLVCIALIEDGMKPLQAVEFVRSKRKNAI-NSPQIKFLKEY
.||.. |.. |.....||..||.|| .|. |  |..||...
tlvaaylmllglsleeavalvrekRpgavqnpsqyrflyyf

0045098 (Phosphotyrosine protein) phosphatases II 11-152 4.9e-28 93.7 In-house 62-267 (278) alignment
Range on Protein: 11-152
Range on HMM: 62-267/278.0
IiessTHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDA----------------------------------------------SLF--EGVK
     ..|||... |...|.  | ...... .  ||...|  ...                                              . .   ||.
y....pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvt

IHEL-CFKDGNVPPKDIIERWLEILKQAFIENGK-------------QKTTVGIHCIAGLGRTPLLVCIALIED----GMKPLQAVEFVRSKRKN-AI-N
.. . .. |..||. .|.  .||.|..    . .             ....| .|| ||.|||  ||.. |. .    |. .|.||...||.| . |. |
hlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqn

SPQIKFLKEY
  |..|| |.
leqyrflyef

0049260 (Phosphotyrosine protein) phosphatases II 17-152 1.4e-27 91.7 In-house 9-145 (152) alignment
Range on Protein: 17-152
Range on HMM: 9-145/152.0
HKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDASLF--EGVKIHELCFKDGNVPPKDIIERWLEILKQAFieNGKQKTTVGIHCIAGLGRTPLL
..|| .  |...|.. |....|.. .  ||...|  ... |.  .. ... | . |..||. ... ..| .. . .  . ... .| .|| ||.|||..|
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtl

VCIALIEDGMKPLQAVEFVRSKRKNAINSP-QIKFLKEY
|.. |.. |.....||..||.||..|. .| |..||.|.
vaaylmllgvsleeavalvrekRpgavpnpgqlrflyef

0042113 (Phosphotyrosine protein) phosphatases II 16-152 9.3e-27 89.4 In-house 51-238 (245) alignment
Range on Protein: 16-152
Range on HMM: 51-238/245.0
THKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEIN---------------------------------------------YDASLFEGVKIHELCFKD
|.|||... |..||.. |  ..... .  ||...|                                               .|   .|.. .| | . |
tpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpd

GNVPP-KDIIERWLEILKQAFIEngKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAI-NSPQIKFLKEY
..||.  ......||....|  |  .....| .|| ||.||| ..... |.      | |. . .||...||.| .|. .  |..|| |.
hgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea

0041856 (Phosphotyrosine protein) phosphatases II 16-156 1.8e-26 88.3 In-house 33-169 (182) alignment
Range on Protein: 16-156
Range on HMM: 33-169/182.0
THKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDASLFEG--VKIHELCFKDGNVPPkdiIERWLEILKQAFIengkQKTTVGIHCIAGLGRTPL
. .||..  |. .|.. | ...|.. .  ||...| .|...|.|   .... | . |..||.   .. .|......      .. .| .|| ||.|||. 
atrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle....eggpvlVHCsaGvgRtgt

LVCIALIE-DGMKPLQAVEFVRSKRKNAINSPQIKFLKEYKASK
||.. |..  |. . .||..|||.| ... .|.  |.  ...  
lvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlalle

0037934 (Phosphotyrosine protein) phosphatases II 16-152 1.3e-25 85.9 In-house 43-237 (243) alignment
Range on Protein: 16-152
Range on HMM: 43-237/243.0
THKFILFDEPTEETIPY----FKDLMKKNSCINIVRCCEIN--------------------------------------------YDASLFEGVKIHELC
| ..|... |..||.      | ...... .  || ..|                                              .|   ......| |.
tprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylp

FKDGNVPP-KDIIERWLEILKQAFIE-----NGKQKTTVGIHCIAGLGRTPLLVCIALIED--GMKPLQAVEFVRSKRKN-AI-NSPQIKFLKEY
. |..||.  ... ..|.....   |     . ... .| .|| ||.||| .|... |. .  |. ...||...|..| . |. .  |..|| |.
wpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea

0040439 (Phosphotyrosine protein) phosphatases II 15-152 1.6e-25 85.6 In-house 52-241 (249) alignment
Range on Protein: 15-152
Range on HMM: 52-241/249.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEIN---------------------------------------------YDASLFEGVKIHELCFK
....||... |..||.. | ...... .  ||....                                               || . ..   |. . . 
ikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp

DGNVP-PKDIIERWLEILKQaFIENGKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAI-NSPQIKFLKEY
| .||   ... ...|.... ..|. .... | .|| ||.|||...... |.      | |. ...||...||.| .|. |  |..|| |.
dhgvppsfedlldfieavrk.aleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea

0046846 (Phosphotyrosine protein) phosphatases II 17-152 1.6e-25 85.3 In-house 23-168 (176) alignment
Range on Protein: 17-152
Range on HMM: 23-168/176.0
HKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEI--------NYDASLFE--GVKIHELCFKDGNVPPKDIIERWLEILKQAFIENgkqkTTVGIHCIA
...| ...|...|.. | ...|.. .  .|...|          .. ...|  |.... | . |..||. ......||....|  |.     .| .|| |
srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg....gpvlVHCsa

GLGRTPLLVCIALIED--GMKPLQAVEFVRSKRK-NAI-NSPQIKFLKEY
|.|||..||.. |.|   |.....|...||..|  .|. .  |..||.|.
GigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyef

0045450 (Phosphotyrosine protein) phosphatases II 15-152 1.8e-25 85.8 In-house 105-299 (307) alignment
Range on Protein: 15-152
Range on HMM: 105-299/307.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDA--------------------------------------------SLFEGVKIHELCF--
...|||... |..||.  |  ..... .  ||...|  ...                                              .|. ... ...  
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

-KDGNVPPK-DIIERWLEILKQaFIENGKQKTTVGIHCIAGLGRTPLLVCIALIEDG---------MKPLQAVEFVRSKRKNAI-NSPQIKFLKEY
  |..|||  ... ...|.... ..|. .... | .|| ||.|||. .... |. ..         . .|.||...|..| .|. |  |..|| |.
wpdhgvppsfeelldfieevrk.aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea

0043336 (Phosphotyrosine protein) phosphatases II 15-151 6.5e-25 83.6 In-house 86-271 (278) alignment
Range on Protein: 15-151
Range on HMM: 86-271/278.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEIN--------------------------------------------YDASLFEGVKIHELCFKD
 ..|||..  |..||.  |  ..... .  ||. .|                                              .|   .... .| |.. |
vprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpd

GNVP-PKDIIERWLEILKQAFIengKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAI-NSPQIKFLKE
..|| . ... ..|.....|.    .... | .|| ||.||| ..... |.      | |. ...||...|..| .|. .  |..|| |
hgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye

0039614 (Phosphotyrosine protein) phosphatases II 16-152 6.6e-25 83.6 In-house 100-284 (297) alignment
Range on Protein: 16-152
Range on HMM: 100-284/297.0
THKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDAS------------------------LFEGVK-----------------IHELCFKDGNVP
|.|||..  |..||.  |  ..... .  ||. .. ...                            .|..                 .. ... |..||
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvp

P-KDIIERWLEILKQAFIENgKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAI-NSPQIKFLKEY
|  ... ..||....|. |. .... | .|| ||.|||  .... |.      | |. .|.||...|..| .|. .  |..|| ..
pslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda

0036282 (Phosphotyrosine protein) phosphatases II 16-152 1.9e-24 81.7 In-house 16-165 (174) alignment
Range on Protein: 16-152
Range on HMM: 16-165/174.0
THKFILFDEPTEetipyFKDLMKKNSCINIVRCCEINYDA--------------SLFEGVKIHELCFKDGNVPPKDIIERWLEILKQAFIEngKQKTTVG
| ..|... |..     | ...|....  .|...| ...                  .|.... | . |..||. .|..........|. |  ... .| 
tprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealse..dpggpvl

IHCIAGLGRTPLLVCIALIEDGM--KPLQAVEFVRSKR----KNAINSPQIKFLKEY
.|| ||.|||..||.. |.. |.  .. .|...||..|    .  ..  |..|| ..
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf

0040438 (Phosphotyrosine protein) phosphatases II 15-152 2.9e-24 81.4 In-house 84-271 (317) alignment
Range on Protein: 15-152
Range on HMM: 84-271/317.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDA--------------------------SLFEGVKIHELCF-------------------K
 ..|||..  |...|.  |  ..... .  ||. .|  ..                              .|.....|..                    
lkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp

DGNVPP-KDIIERWLEILKQAFiEngKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAINSP-QIKFLKEY
|..|||  |.. ..||....|. |  .... | .|| ||.|||  .... |.      | |. . .||...|..| .|. .| |..|| ..
dhgvppspdllldfleavreal.e..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda

0044763 (Phosphotyrosine protein) phosphatases II 18-153 9.6e-23 76.2 In-house 29-167 (178) alignment
Range on Protein: 18-153
Range on HMM: 29-167/178.0
KFILFDEPTeetiPYFKDLMKKNSCINIVRCCEINY------DASLFEG--VKIHELCFKDGNVPP-KDIIERWLEILKQAFienGKQKTTVGIHCIAGL
 ..| . |.    . ...|.|.. .  ||...|  .      |.  .|.  .. . . . |..||.  .......|....|     ... .| .|| ||.
glylgslpp....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal...dekggpvlVHCsaGv

GRTPLLVCIALI-EDGMKPLQAVEFVRSKRKNAINSPQIKFLKEYK
||...||.. |. . |. . .|.|.||..|   .|  |...|.|. 
gRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefe

PTEN_1 32-157 1.2e-22 75.7 In-house 58-192 (196) alignment
Range on Protein: 32-157
Range on HMM: 58-192/196.0
YFKDLMKKNSCINIVRCCEIN------YDASL--FEGVKIHELCFKDGNVPPKDIIERWLEILKQAFIENGKqKTTVGIHCIAGLGRTPLLVCIALIEDG
 ..| .|...   .|. .|.       || ..   .||. ... ..| ..|. . . .... .... ... . . .| .|| |||||. ..|.  |.. |
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaayLmykg

-MKPLQAVEFVRSKR-KNAINSPQIKFLKEYKASKK
 . . .|.|.||.|| ..|.|||. . |.|| |. .
kltadeAlelvrekRppgapnspsqerlleyfaell

0049772 (Phosphotyrosine protein) phosphatases II 17-154 1.8e-22 75.9 In-house 155-271 (314) alignment
Range on Protein: 17-154
Range on HMM: 155-271/314.0
HkfilfDEPTEETIPYFKdlmkknscinivrccEINYDASLFEG--VKIHELCFKDGNVPPKDIIERWLEILKQAfiengKQKTTVGIHCIAGLGRTP--
.     .|||.......|               |. ||..|||.  .| . . . ||..|. ......||....|     .... | .|| || |||.  
g.....neptaadlellk...............eelydpelferlgikylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtf

LLVCIALIEDGMKPLQAVEFVRSKRKNAINSPQIKFLKEYKA
..... ..  |. . .|.|.||.||   .|  .|..|..|  
vvaaylmkllgvsleealedvrlkRpinpnpgfieqleqyef

0047943 (Phosphotyrosine protein) phosphatases II 15-145 2.6e-22 75.0 In-house 75-259 (273) alignment
Range on Protein: 15-145
Range on HMM: 75-259/273.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYD----------------ASLFEGVKI--------------------------------HEL
...|||... |...|.  | ...... .  ||. .|. ..                   .. ...                                | .
lkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhyt

CFKDGNVP-PKDIIERWLEILKQAFIENGKQkTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAINSPQ
 . | .||   ... ...|....|. .. .. ..| .|| ||.|||  .... |.      | |. .|.|| ..||.| ... .|.
gwpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe

0050432 (Phosphotyrosine protein) phosphatases II 7-145 6.2e-22 73.8 In-house 98-286 (308) alignment
Range on Protein: 7-145
Range on HMM: 98-286/308.0
HIETIIESSTHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINY----------------DASLFEGVK----------------------------
.. . .  ...|||..  |...|.  |  .. .. .  ||. ... .                .   .....                            
yvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesr

----IHELCFKDGNVPPK-DIIERWLEILKQAFiengkQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAINSPQ
    .| .  .|..|||. .|. ..||.... .     .. .. .|| ||.|||  .... |.      | |. ...|| ..|..| .....|.
tvthfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe

0051299 (Phosphotyrosine protein) phosphatases II 15-145 2e-21 72.2 In-house 90-273 (288) alignment
Range on Protein: 15-145
Range on HMM: 90-273/288.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEIN-------------------------------------------------YDASLFEGVKIHE
...|||..  |...|.  |  .. .. .  ||. ...                                                  .|   ..   .| 
lkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhy

LCFKDGNVPP-KDIIERWLEILKQAFIengKQKTTVGIHCIAGLGRTPLLVCIALI------EDGMKPLQAVEFVRSKRKNAINSPQ
. . | .||.  . . ..|.....|.    ... .| .|| ||.|||  .... |.      | |. .|.||...|..| .....|.
tnwpdhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe

0046845 (Phosphotyrosine protein) phosphatases II 15-145 1.1e-19 66.4 In-house 75-261 (284) alignment
Range on Protein: 15-145
Range on HMM: 75-261/284.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINY-----------------------------------------------DASLFEGVKIHELC
...|||..  |...|.  |  .. .. .  ||  .|.                                                 .   ..   .| . 
ikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhyts

FKDGNVPP-KDIIERWLEILKQAFIEnGKQKTTVGIHCIAGLGRTPLLVCIALIED---------GMKPLQAVEFVRSKRKNAINSPQ
. | .|||  ... ..|....... .  ... .. .|| ||.|||  .... |. .         |. .|.|| ..|..| .......
wpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle

0048179 (Phosphotyrosine protein) phosphatases II 27-153 2.5e-19 64.9 In-house 19-141 (144) alignment
Range on Protein: 27-153
Range on HMM: 19-141/144.0
EETIPYFKDlMKKNSCINIvrCCEINYDASLFEGVKIHELCFKDGNVPPK-DIIERWLEILKQAFIengkQKTTVGIHCIAGLGRTPLLVCIALI-EDGM
 . ....|. .. .  ||.  . |  ..   .||.... | . | .||.  ......||....|      ..  | .|| ||.|||..||.. |. . |.
aldlellkk.lgittvinl..teeyepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmkklgl

KPLQAVEFVRSKRKNAI-NSPQIKFLKEYK
 . .|...|||.| .|. |  |..||.|| 
sleealalvrsrrpgavpnpgqlrfLleye

0051082 (Phosphotyrosine protein) phosphatases II 15-148 3e-19 64.5 In-house 14-143 (151) alignment
Range on Protein: 15-148
Range on HMM: 14-143/151.0
SthkFILFDEPTEETIPYFKDlMKKNSCINIVRCCEINYDASLFEG--VKIHELCFKDGNVPPK----DIIERWLEILKQafiengKQKTTVGIHCIAGL
    ..... |... ....|. .. .. .|.    |..|......   .... . . |  .|.     |.. . ||.| .      |..  | .|| ||.
g...lyrsggpladflellke.lgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGk

GRTPLLVCIALIEDGMKPLQAVEFVRSKRKNAINSPQIKF
||| .||.. |.  |. . .|.|..|.|| ......|  .
gRTGtlvalylmllgvsleealeeyrlkrpgvvqpnqqfl

subfamily_CDC14_pd Subfamily CDC14 27-153 5.9e-19 63.1 In-house 202-320 (328) alignment
Range on Protein: 27-153
Range on HMM: 202-320/328.0
EETIPYFkdlmKKNSCINIVRCCEINYDASLFE--GVKIHELCFKDGNVPPKDIIERWLEILKQAfiengkqKTTVGIHCIAGLGRTPLLVCIALI-EDG
|. ..||    .||   ..||  . .|||. |.  |.. ..| | || .|.. |....|||...|       . .. .|| ||||||  |.   |. . .
eklleyf....rknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.......eGaiavhCkaGLGrtGtLiacylmkhyr

MKPLQAVEFVRSKRKNAINSPQIKFLKEYK
.   .|. ..|  |   . .|| |||.| .
ftaaeaiawlricrPGsvigpqqkfleekq

0048076 (Phosphotyrosine protein) phosphatases II 38-152 7.3e-19 63.3 In-house 26-138 (145) alignment
Range on Protein: 38-152
Range on HMM: 26-138/145.0
KKNSCINIVRCcEINYDASLFEGVKIHELCFKDGNVPPK-DIIERWLEILKQAFIENgkqkTTVGIHCIAGLGRTPLLVCIALIED-GMKPLQAVEFVRS
|..    ....   . .    .|.... | . | .||.  ......||....|  |.      | .|| ||.|||..||.. |.   |. . .|.|.|||
kdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrs

KRKNAI-NSPQIKFLKEY
.| .|. |  |..||.|.
qrpgavpnpgqlrflyef

0036941 (Phosphotyrosine protein) phosphatases II 15-150 1e-16 56.6 In-house 76-270 (297) alignment
Range on Protein: 15-150
Range on HMM: 76-270/297.0
STHKFILFDEPTEETIPYFKDLMKKNSCINIVRCCEINYDAS------------------------------LFEGVKIHELC-----------------
 ..|||.   |...|.  |  .. .. .  ||  .|   .                                |........|.                 
lkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhy

--FKDGNVPP-KDIIERWLEILKQAFiENGKQKTTVGIHCIAGLGRTPLLVCIAL---------IEDGMKPLQAVEFVRSKRKNAINSP-QIKFLK
    | .||.  ... ...| ....  ..  ... | .|| ||.||.  .... |         .| |. .|.|| ..|..| .|. .. | .|| 
tgwpdhgvpespaslldfielvrkvl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly

subfamily_PTPDC1_pd Subfamily PTPDC1 59-154 2.3e-14 48.3 In-house 81-173 (182) alignment
Range on Protein: 59-154
Range on HMM: 81-173/182.0
EGVKIHELCFKDGNVPPkdiIERWLEILKqaFIENGKQKTTVGIHCIAGLGRTPLLVCIALI-EDGMKPLQAVEFVRSKRKNAINS-PQIKFLKEYKA
.|. .... .|| .|..   .|| |.| |   ..   |.  |..|| |||||| .|..  |.  . ... .|...||||| ..|..  |....||...
qgiyvynfgwkDygvas...leriLdivk..vvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkefal

0051429 (Phosphotyrosine protein) phosphatases II 45-151 4.1e-14 48.4 In-house 52-219 (272) alignment
Range on Protein: 45-151
Range on HMM: 52-219/272.0
IVRCCEINYD--ASLFEGVKIHELCFKDGNVPPK----------------------------------------------------DIIERWLEILKQaf
. ...|....    . .|.... | . |  .|.                                                     . . ..||.| .  
LrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld..

iengkqKTTVGIHCIAGLGRTPLLVCIALIEDGMK--------------PLQAVEFVRSKRKNAINSPQ-IKFLKE
      .  | .|| || .|| ..|.. |.  |.               ...||| .|..| .|. ... ..|| |
......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye

subfamily_PTEN_pd Subfamily PTEN 24-150 2e-12 42.5 In-house 45-173 (184) alignment
Range on Protein: 24-150
Range on HMM: 45-173/184.0
EPTEETIPYFKDLMKKNSCINIVrCCEINYDASLFEGvKIHELCFKDGNVPPKDIIERWLEILKQaFIENGKqKTTVGIHCIAGLGRTPLLVCIALIEDG
  .|... ...   |..  |  . . | .||.. |.| ..... |.| | || ...|. .| ... ..|. | |  | .|| || ||| .|..  |.. .
nsledvvkflekkhkdhykiynl.rserkydskkfdg.rvavypfdDhnppplelleeivediek.wleedk.knvvvvHCkaGkGRtGvlivayllksl

MKPLQ--AVEFV---RSKRKNAINSP-QIKFLK
. . .  |.|.    |.| |...  | |.....
llekaeealelfaeaRtknkkgvtiPsqrRYve

PTPc_motif_SM00404 40-151 1.2e-11 39.7 In-house 29-133 (140) alignment
Range on Protein: 40-151
Range on HMM: 29-133/140.0
NSCINIVRCCEINYDASLFEGVKIHeLCFkDGNVPPKDIIERWLEILKQAfienGKQKTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRk
  .||. . .....  | |. ..|  |   ... .  . ... |.....|     |....| .|| ||. |.  |..  |.. ....  .|.|||...| 
thvinvteevsltkensgfqilqip.ldd.nekdklskyldkvldfiena....ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR.

nAINSPQIKFLKE
  | ||...|...
.piispnlnfvrq

subfamily_DSP11_pd Subfamily DSP11 60-143 3.5e-11 37.3 In-house 79-163 (178) alignment
Range on Protein: 60-143
Range on HMM: 79-163/178.0
GVKIHELCFKDGNVPPKDIIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRKNAINS
||| . |     .|| ....... | .|.   .| .... .|.||  |. ||  |.|  ||. .|..| .|.|   . |  ... 
gvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsler

subfamily_VSP_pd Subfamily VSP 15-140 6.9e-11 36.5 In-house 50-173 (212) alignment
Range on Protein: 15-140
Range on HMM: 50-173/212.0
STHKFILFDEPTEETIPYFKDlMKKNSCINIVRCCEINYDASLFEGvKIHELCFKDGNVPPKDIIERWLEILKQaFIENGkQKTTVGIHCIAGLGRTPLL
|. |  |. .| .|   ...    ..    .  | | .|| . |.  .....   | |||  . .    ...|. ..|.  .|  . |||  | |||  .
ssGkqslyrnpisevarfldt.khrdhykvvnlcseraydekyfnn.rvkriliddhnvpkleellvftkevke.wlekd.lknvlaihckGGkgrtGti

VCIALIEDGMK--PLQAVEFVRSKRKNA
||  |.. ..     .....  ..| . 
vcalllaseifetakesldyfgerrtdk

DSPc Dual specificity phosphatase, catalytic domain 43-151 7.3e-11 37.1 Pfam-A 23-129 (133) alignment
Range on Protein: 43-151
Range on HMM: 23-129/133.0
INIVRCCEINydaSLFEGVKIHELCFKdGNVPPKDIIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRknAI
||. . .. |    ...  .|..|. .  .   .. |...|| ...   .  ... .| .|| ||. |.. |..  |.. ....  .|.|||...|   .
invtkevpnn...naikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..sk

NSPQIKFLK---E
 ||...||.   |
ispnagflrqLle

DSPc Dual specificity phosphatase, catalytic domain 43-151 7.3e-11 37.1 In-house 23-129 (133) alignment
Range on Protein: 43-151
Range on HMM: 23-129/133.0
INIVRCCEINydaSLFEGVKIHELCFKdGNVPPKDIIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRknAI
||. . .. |    ...  .|..|. .  .   .. |...|| ...   .  ... .| .|| ||. |.. |..  |.. ....  .|.|||...|   .
invtkevpnn...naikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..sk

NSPQIKFLK---E
 ||...||.   |
ispnagflrqLle

0048567 (Phosphotyrosine protein) phosphatases II 48-150 2.3e-10 35.0 In-house 23-131 (157) alignment
Range on Protein: 48-150
Range on HMM: 23-131/157.0
CCEINYDASLF---EGVKIHELCFKDGnVPPKDIIERWLEILKQAFIENGKQKTTVGIHCIAGL---GRTPLLVCI-ALIEDGMKPLQAVEFVRSKRKNA
  . .|.|  |   .|.  ....|..|  .. .|. |.  .|.. .    ... .. .|| |||   ||| .|..  ...  |. | .|....|  | . 
lpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgs

INSPQIKFLK
.  ..  .| 
vpfrdasyll

subfamily_PTPMT1_pd Subfamily PTPMT1 59-155 1.3e-09 32.8 In-house 72-167 (171) alignment
Range on Protein: 59-155
Range on HMM: 72-167/171.0
EGVKIHELCFKDGN-VPPKDIIERWLEILKQAFiengKQKTTVGIHCIAGLGRTPLLVCIAL-IEDGMKPLQAVEFVRSKRKN-AINSPQIKFLKEYKAS
.||.. .|  .|    |  . .|. .|....      ... .| .|| || ||.  ||   |  .. ..| .|......|||   ... | | |.||. .
lgveqlqlatvDfteapdleklekgvefiekva....skgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek





subfamily_CDKN3_pd Subfamily CDKN3 60-156 3.1e-09 30.7 In-house 99-195 (202) alignment
Range on Protein: 60-156
Range on HMM: 99-195/202.0
GVKIHELCFKDGNVPPKDIIERWLEILKQAFiengKQKTTVGIHCIAGLGRTPLLV-CIAL-IEDGMKPLQAVEFVRSKR-KNAINS-PQIKFLKEYKAS
|. .|   . || ||      . || |. ..    |. .   .||  ||||. |.. |. | ..| ..| .|.. .|  .  .||..  |  .|.|..  
glivhhypiadglvpdiasclkileelrinl....kayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsefrdk

K
.
l

PTPc_DSPc_SM00012 69-144 3.7e-09 32.1 In-house 11-93 (105) alignment
Range on Protein: 69-144
Range on HMM: 11-93/105.0
KDGNVPPK-DIIERWLEILKQAFIENGKqKTTVGIHCIAGLGRTPLLVCIALIEDG-------MKPLQAVEFVRSKRKNAINSP
.| .|| . | | ..|. .|.   .... .. | .|| || |||  .|..... .        .. .| |. .|..| ..... 
pdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte

subfamily_DSP23_pd Subfamily DSP23 59-147 6.7e-09 30.6 In-house 50-136 (148) alignment
Range on Protein: 59-147
Range on HMM: 50-136/148.0
EGVKIHELCFKDGNVPPKDIIERWLEILKQAfienGKQKTTVGIHCIAGLGRTPLLV-CIALIEDGMKPLQAVEFVRSKRKNAINS-PQIK
 .. ...|  .|   |  . ..........|     ... .|..||. | |||  .. |  . | ..   .|.  || .|  ....  | |
pnltlvrlriddyhppaleqvvefvrvveea....eekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqek

Y_phosphatase Protein-tyrosine phosphatase 68-145 7.3e-09 30.8 Pfam-A 143-225 (235) alignment
Range on Protein: 68-145
Range on HMM: 143-225/235.0
FKDGNVPPKdiIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIEDGMKP------LQAVEFVRSKRKNAINSP-Q
 .| .|| .   .  |.....   .. .... | .||.|| |||  .|.. .. . ..       ||.|. .|..| ....|  |
Wpdhgvpes..pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq

Y_phosphatase Protein-tyrosine phosphatase 68-145 7.3e-09 30.8 In-house 143-225 (235) alignment
Range on Protein: 68-145
Range on HMM: 143-225/235.0
FKDGNVPPKdiIERWLEILKQAFIENGKQKTTVGIHCIAGLGRTPLLVCIALIEDGMKP------LQAVEFVRSKRKNAINSP-Q
 .| .|| .   .  |.....   .. .... | .||.|| |||  .|.. .. . ..       ||.|. .|..| ....|  |
Wpdhgvpes..pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq

subfamily_DSP19_pd Subfamily DSP19 75-156 1.5e-08 29.1 In-house 68-150 (152) alignment
Range on Protein: 75-156
Range on HMM: 68-150/152.0
PKDIIERWLEIlkQAFIENGKQK-TTVGIHCIAGLGRTPLLVCIALIEDGMKPL-QAVEFVRSKRKNA-INSPQIKFLKEYKASK
 .|... . |.  . |||....|  .| .|| ||  |.. .|   |...  . | .|.| ||..|...  |.  || ||||.|..
etdllsylkea..ldFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael

subfamily_RNGTT_pd Subfamily RNGTT 54-143 2.8e-08 27.7 In-house 69-160 (189) alignment
Range on Protein: 54-143
Range on HMM: 69-160/189.0
DASLF--EGVKIHELCFK-DGNVPPKDIIERWLEILKQaFIEnGKQKTTVGIHCIAGLGRTPLLVCIALIEDGMKP-LQAVEFVRSKRKNAINS
|.. .  ||.| ..|  .  |. | .. .... ..... |..  . ....|.||  |  ||  |..  |.|       .||.  .. |.  |  
dkeelekegikyvklqcagkgeaPeaeqvkefiklvee.ffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyk

subfamily_LRR-DSP_pd Subfamily LRR-DSP 74-151 3.3e-08 26.9 In-house 176-253 (263) alignment
Range on Protein: 74-151
Range on HMM: 176-253/263.0
PPKDIIERWLEIlkQAFIENGKQKTTVGIHCIAGLGRTPLLVC-IALIEDGMKPLQAVEFVRSKRKNAInsPQIKF---LKE
.  ||   . |.   ||||.|..|  | .|| ||. |.  ||    .  . .|  .|...| .|| .    | . |   || 
deadisqhfeet..nafieeGrkkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriq..PnpGfkdqlkk

subfamily_DSP1_pd Subfamily DSP1 43-152 1.3e-07 25.8 In-house 48-149 (163) alignment
Range on Protein: 43-152
Range on HMM: 48-149/163.0
INIVRCCEINYDAsLFEGVKIHelcFKDGnvPPKDIIERWLEILKqaFIENGKQ-KTTVGIHCIAGLGRTPLLVCIALIE-DGMKPLQAVEFVRSKRKna
.|. . ..  ..  |||  |..    .|   | .|| . . |...  ||.. |. .  | ||| ||. |   |. . |.. . ..  .| .||...|.  
lnvskeldnvfed.lfeYkklk...leDs..pkadislvfeevie..fidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRs..

INSPQIKFLKEY
| || . | .. 
iisPnagFvlqL

subfamily_DSP12_pd Subfamily DSP12 76-161 1.3e-07 26.1 In-house 62-145 (155) alignment
Range on Protein: 76-161
Range on HMM: 62-145/155.0
KDIIERwLEILkQAFIENGK-QKTTVGIHCIAGLGRTPLlVCIALI--EDGMKPLQAVEFVRSKRKNAinSPQIKFLKEYKASKKAGCK
.||..  |.    .|||..  .. .| .|| ||. |    ..|| .  .....  .|...|..|....  .|   ||.  |  .| |||
ediLsh.ldea.vdFieealeeegavlvHCqagvSRSvt.iviAYlmkkeklslekAlklvkekkpei..epNegFleQLklfekmgck

subfamily_DSP10_pd Subfamily DSP10 88-151 2.2e-07 24.9 In-house 82-145 (159) alignment
Range on Protein: 88-151
Range on HMM: 82-145/159.0
QAFIENGKQK-TTVGIHCIAGLGRTPLLVCIAL-IEDGMKPLQAVEFVRSKRknAINSPQIKFLKE
 .|||. ..| ..| .|| ||. |   .|   |  . ...  .| .||..||  .| || . |. .
lefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekr..piisPnLnfmGq

subfamily_DSP3_pd Subfamily DSP3 47-153 4.4e-07 23.7 In-house 47-154 (162) alignment
Range on Protein: 47-153
Range on HMM: 47-154/162.0
RCCEINYDASLFEGVKIHELCFKDGNVPPKDIIERWLEIlkQAFIENG--KQKTTVGIHCIAGLGRTPLLVCI-ALIEDGMKPLQAVEFVRSKRKNAINS
|  ... .|. .....|. | ..  .||  |. . . .    .||..   .... | .|| .|. | . ||    .|   |.  .|.. ||.||.   |.
rfskvdtgaefykdleikylGlevdDvpefdlskyFeta..akfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPne

PQIKFLKEYK
  .| |.|..
GFlkqLaeld

MOZART1 Mitotic-spindle organizing gamma-tubulin ring associated 107-128 1.1e-06 15.5 Pfam-A 18-39 (48) alignment
Range on Protein: 107-128
Range on HMM: 18-39/48.0
GLGRTPLLVCIALIEDGMKPLQ
|| |. | .||.|.| |..| .
gLdreaLsicieLleaGVnPea

subfamily_DSP6_pd Subfamily DSP6 89-151 3.5e-06 20.6 In-house 84-146 (158) alignment
Range on Protein: 89-151
Range on HMM: 84-146/158.0
AFIENGKQK-TTVGIHCIAGLGRTPLLVCIALIEDGMKPL-QAVEFVRSKRKNAinSPQIKFLKE
.||.....| ..| .||.||. |.  ..   |..  .  | .| ..|.... |   ||  .|.. 
efidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksni..sPnfnfmgq