Gene DDB_G0292024 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP020_AA protein Get Run
DdisP020_AA_12-160 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PRL_pd Subfamily PRL 13-160 2.4e-70 229.4 In-house 3-150 (151) alignment 
Range on Protein: 13-160
Range on HMM: 3-150/151.0
SLVESSTHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKETIGIHCVAGLG
. .|....||||.|.|.|..|. .|.||||..|...||.|.|||.||.|.. ||.|.|..|.||..||..||..|...| |..|...|.|...|||||||
veieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlG

RAPVLVAIALIEGGMNPLQAVEYIRERRRGSINIKQIQYLKNYKSKKK
|||||||.|||| ||.. .|||.|||.|||.|| ||...|..||.|||
raPvlvalalieaGmkyedavefirekrrgainskqlkflekykakkk
0038934 (Phosphotyrosine protein) phosphatases II 19-156 2.7e-36 120.4 In-house 17-170 (194) alignment 
Range on Protein: 19-156
Range on HMM: 17-170/194.0
THRFLIFDAPNDDNLPLYINELKKYNVSHLVRAC----------------DPTYSTEPLQAIGIQVHDMPFAD-GGSPPDAVVNNWIKILGESYKKDSKE
| ||..|. | ...|  ||.||.......||| .                ...|..| ... ||.....|| | | .|............ | ...|...
tgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpgg

TIGIHCVAGLGRAPVLVAIALIE-GGMNPLQAVEYIRERRRGSIniKQIQYLKNYK
....||.|||||...||| .||.  ||.. .|....||.|.|.|   ...||. . 
vvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai..pnqdyleall
0043147 (Phosphotyrosine protein) phosphatases II 18-157 1.7e-34 114.4 In-house 18-158 (172) alignment 
Range on Protein: 18-157
Range on HMM: 18-158/172.0
STHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKETIGIHCVAGLGRAPVL
 ..||... .| . .|. ... ||.....|.|.... .| .|.|.  |||.. .|. |.| |. ... ...... | . ....... .||.||.||...|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtl

VAIALIEGGMNPLQAVEYIRERRRGSI-NIKQIQYLKNYKS
||. |.. |.....||...||.|.|.. |  |...|. . .
vaaylmllglsleeavalvrekRpgavqnpsqyrflyyfek
0049260 (Phosphotyrosine protein) phosphatases II 20-157 4.7e-32 106.2 In-house 9-147 (152) alignment 
Range on Protein: 20-157
Range on HMM: 9-147/152.0
HRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKETIGIHCVAGLGRAPVLVA
..|... .| . .|. ... ||.......|. ..... ...  . .||.. .|. |.| |... .  .. .. | ...|..... .||.||.||...|||
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

IALIEGGMNPLQAVEYIRERRRGSI-NIKQIQYLKNYKS
. |.. |.....||...||.| |.. |  |...|... .
aylmllgvsleeavalvrekRpgavpnpgqlrflyefek
0046846 (Phosphotyrosine protein) phosphatases II 20-156 5.8e-30 99.7 In-house 23-169 (176) alignment 
Range on Protein: 20-156
Range on HMM: 23-169/176.0
HRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDP--------TYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDskETIGIHCVAGL
.|......|  ..|. .. .||.......|. ...        ..  . |.. |||.. .|. |.| |... . ...... | .|..  ... .||.||.
srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGi

GRAPVLVAIALIEG--GMNPLQAVEYIRERRR-GSI-NIKQIQYLKNYK
||...|||. |.|   |.....|....||.|. |.. . .|...|. . 
gRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefe
0040439 (Phosphotyrosine protein) phosphatases II 14-155 1.3e-29 99.0 In-house 46-241 (249) alignment 
Range on Protein: 14-155
Range on HMM: 46-241/249.0
LVES--STHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPT---------------------------------------------YSTEPLQAIGI
...   ...||.....| .. .. ... |........|......                                             |  |...  .|
yidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhi

QVHDMPfaDGGSP-PDAVVNNWIKILGESYKKD-SKETIGIHCVAGLGRAPVLVAIALI------EGGMNPLQAVEYIRERRRGSI-NIKQIQYLKNY
|..|.|  | | |   . . ..|... . .... ... . .|| ||.||.....|. |.      |.|.....||...|..|.|.. |  |...| ..
qytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0036282 (Phosphotyrosine protein) phosphatases II 19-157 1.4e-29 98.4 In-house 16-167 (174) alignment 
Range on Protein: 19-157
Range on HMM: 16-167/174.0
THRFLIFDAPNDdnlplYINELKKYNVSHLVRACDPTYST------------EPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKETIGIH
| |......| .     .. .||.......|. ... .              | |   |||....|. |.| |..... ...|.. | ...|.. .. .|
tprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVH

CVAGLGRAPVLVAIALIEGGM--NPLQAVEYIRERR----RGSINIKQIQYLKNYKS
| ||.||...|||. |.. |.  .. .|....||.|    .. ..  |...|  ...
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0042113 (Phosphotyrosine protein) phosphatases II 13-155 1.6e-29 98.5 In-house 24-238 (245) alignment 
Range on Protein: 13-155
Range on HMM: 24-238/245.0
SLVESS---------------------THRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYS----------------------------------
..|  |                     |..|.....| ..... ... |........|. .....                                   
trvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddyt

---------TEPLQAIGIQVHDMPFADGGSPP-DAVVNNWIKILGESYKKDSKETIGIHCVAGLGRAPVLVAIALI------EGGMNPLQAVEYIRERRR
          .. .  .|..| .|. |.| |. .. . ...... . ...||.... .|| ||.||. ...|. |.      |.|... .||...|..|.
vrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRp

GSI-NIKQIQYLKNY
|.. .  |...|  .
gavqtpsqyrflyea
0045098 (Phosphotyrosine protein) phosphatases II 12-155 2.4e-28 94.8 In-house 56-267 (278) alignment 
Range on Protein: 12-155
Range on HMM: 56-267/278.0
ASLVESSTHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYST----------------------------------------------EPLQAIG
||.... ...|.....| ....  ... |........|.... .. .                                              | |.  |
AsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrg

IQVHDM-PFADGGSPPDAVVNNWIKILGESYK---------------KDSKETIGIHCVAGLGRAPVLVAIALIEG----GMNPLQAVEYIRERRRG-SI
...... |. |.|.|.. ... ....| .  .                ||.... .|| ||.||. .|||. |.      |...|.||...|..|.| ..
vthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglav

-NIKQIQYLKNY
 |  |...|  .
qnleqyrflyef
0041856 (Phosphotyrosine protein) phosphatases II 19-154 1e-27 92.3 In-house 33-164 (182) alignment 
Range on Protein: 19-154
Range on HMM: 33-164/182.0
THRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGEsykkdSKETIGIHCVAGLGRAPVLV
. ||... .| ..... ... ||.......|..... |  | |.  |||....|. |.| |.   ....|..  |     ..... .|| ||.||...||
atrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eggpvlVHCsaGvgRtgtlv

AIALIE-GGMNPLQAVEYIRERRRGSINIKQIQYLKN
|. |..  |... .||...|.|| |.. . .  ..  
aaylmkklgvsleeavklvrsrRpgmvitpnqyfflq
0044763 (Phosphotyrosine protein) phosphatases II 20-158 1.9e-27 91.4 In-house 28-169 (178) alignment 
Range on Protein: 20-158
Range on HMM: 28-169/178.0
HRFLIFDAPNddnlPLYINELKKYNVSHLVRACDPTY------STEPLQAIGIQVHDMPFADGGSPP-DAVVNNWIKILGESYKkDSKETIGIHCVAGLG
..... ..|.    . ... ||.....|.|. .....        . ..  |||.. .|. |.| |. .. . ...... | .. ...... .|| ||.|
pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvg

RAPVLVAIALI-EGGMNPLQAVEYIRERRRGSINIKQIQYLKNYKSK
|...|||. |. . |... .|.|..||||....|  |...|. . ..
RsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelr
0045450 (Phosphotyrosine protein) phosphatases II 18-155 4.4e-27 91.0 In-house 105-299 (307) alignment 
Range on Protein: 18-155
Range on HMM: 105-299/307.0
STHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYSTEP------------------------------------------LQAIGIQVHDMPF--
....|.....| ....  ... |....|...|. ..... . .                                              ...|. ...  
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

-ADGGSPPD-AVVNNWIKILGESYKKD-SKETIGIHCVAGLGRAPVLVAIALIEGG---------MNPLQAVEYIRERRRGSI-NIKQIQYLKNY
  |.| ||. . . ..|... . .... ... . .|| ||.||.....|. |.  .         ...|.||...||.| |.. |  |...| ..
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 15-154 8e-27 89.8 In-house 81-271 (278) alignment 
Range on Protein: 15-154
Range on HMM: 81-271/278.0
VESS--THRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPT--------------------------------------------YSTEPLQAIGIQV
|.    ...|... .|.....  ... .....|...|. ....                                            .. |...  ... 
vdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhy

HDMPfaDGGSP-PDAVVNNWIKILGESYKkDSKETIGIHCVAGLGRAPVLVAIALI------EGGMNPLQAVEYIRERRRGSI-NIKQIQYLKN
...|  |.| | . . . ...|.. | .. ||.. . .||.||.||. ...|. |.      |||.....||...||.| |.. .  |...| .
lgwp..dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0039614 (Phosphotyrosine protein) phosphatases II 17-155 3.1e-26 88.0 In-house 95-284 (297) alignment 
Range on Protein: 17-155
Range on HMM: 95-284/297.0
SS---THRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYSTE----------------------PLQ-----------------AIGIQVHDMPFA
     |..|... .|.....  ... .....|...|. .....                           .                  .  ... ... 
gydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp

DGGSPP-DAVVNNWIKILGESYKKD-SKETIGIHCVAGLGRAPVLVAIALI------EGGMNPLQAVEYIRERRRGSI-NIKQIQYLKNY
|.| ||  ... ...... | .... ... . .||.||.||. ...|. |.      |||...|.||...||.|.|.. .  |...| ..
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0037934 (Phosphotyrosine protein) phosphatases II 11-155 3.4e-26 87.7 In-house 36-237 (243) alignment 
Range on Protein: 11-155
Range on HMM: 36-237/243.0
PASLVESStHRFLIFDAPNDDNLPL----YINELKKYNVSHLVRACDPT------------------------------------------YSTEPLQAI
.|.|..    |. ....| ....      ... |........|  ....                                          .....|.  
nanliyvt.prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrl

GIQVHDMPFADGGSPP-DAVVNNWIKILGESYKK-------DSKETIGIHCVAGLGRAPVLVAIALIEG--GMNPLQAVEYIRERRRG-SI-NIKQIQYL
.|..| .|. |.| |.  . . ...... | ...       ||.... .||.||.||. .|.|. |.    |.....||...||.| | .. .  |...|
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfl

KNY
  .
yea
0040438 (Phosphotyrosine protein) phosphatases II 13-155 7.1e-24 80.1 In-house 77-271 (317) alignment 
Range on Protein: 13-155
Range on HMM: 77-271/317.0
SLVESS--THRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYS------------------------TEPLQAIGIQVHDMPF-------------
|.|.    ...|... .| .. .  ... .....|...|. .....                         ..  .  ||... ...             
syvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvth

------ADGGSPP-DAVVNNWIKILGESYKkDSKETIGIHCVAGLGRAPVLVAIALI------EGGMNPLQAVEYIRERRRGSI-NIKQIQYLKNY
       |.| ||    . ...... |... |... . .||.||.||. ...|. |.      |||... .||...||.|.|.. .  |...|  .
fhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0048179 (Phosphotyrosine protein) phosphatases II 35-156 2.4e-23 77.9 In-house 20-141 (144) alignment 
Range on Protein: 35-156
Range on HMM: 20-141/144.0
LYINELKKYNVSHLVRACDPtYSTEPLQAIGIQVHDMPFADGGSPPD-AVVNNWIKILGESYKKDskETIGIHCVAGLGRAPVLVAIALI-EGGMNPLQA
| . .|||........ ... |  | |   |||.. .|. | | |.. . ........ | ....  . . .|| ||.||...|||. |. . |... .|
ldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkklglsleea

VEYIRERRRGSI-NIKQIQYLKNYK
....|.|| |.. |  |...|..| 
lalvrsrrpgavpnpgqlrfLleye
0051082 (Phosphotyrosine protein) phosphatases II 18-152 2.8e-23 77.6 In-house 14-144 (151) alignment 
Range on Protein: 18-152
Range on HMM: 14-144/151.0
SthrFLIFDAPnddnLPLYINELKKYNVSHLVRACDPT---YSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKETIGIHCVAGLGRA
    ......|    |. ....||...... |  ....   | .|.|.. ||.|...|. |   |.  .  .... . | . ....  . .|| ||.|| 
g...lyrsggp....ladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

PVLVAIALIEGGMNPLQAVEYIRERRRGSINIKQIQYL
 .|||. |.  |... .|.|..|..| |... .| ...
Gtlvalylmllgvsleealeeyrlkrpgvvqpnqqflf
0049772 (Phosphotyrosine protein) phosphatases II 22-158 1.8e-22 75.9 In-house 148-272 (314) alignment 
Range on Protein: 22-158
Range on HMM: 148-272/314.0
FLIFDAPNDDNLPLYINELKkynvshlvracDPTYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESykkDSKETIGIHCVAGLGRAP--VLVA
.||.| ...   . .. .||           . .|. | ..  ||.....|. ||. |... .. ..... |    | .. . .|| || ||..  |..|
llildgngneptaadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaa

IALIEGGMNPLQAVEYIRERRRGSINIKQIQYLKNYKSK
. ..  |... .|.|..|..|  ..|  .|. |..|  .
ylmkllgvsleealedvrlkRpinpnpgfieqleqyefi
0047943 (Phosphotyrosine protein) phosphatases II 18-148 4.4e-22 74.3 In-house 75-259 (273) alignment 
Range on Protein: 18-148
Range on HMM: 75-259/273.0
STHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTYS----------------------------------------------TEPLQAIGIQVHDM
....|.....| ....  ... ....||...|. .....                                                 .   . ...| .
lkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhyt

PFADGGSPP-DAVVNNWIKILGESYKKD-SKETIGIHCVAGLGRAPVLVAIALI------EGGMNPLQAVEYIRERRRGSINIKQ
.. | | ||  . . ..|... . .... |.... .||.||.||. ...|. |.      |||...|.|| ..|..| |..   .
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe
0048076 (Phosphotyrosine protein) phosphatases II 36-156 6e-22 73.3 In-house 21-139 (145) alignment 
Range on Protein: 36-156
Range on HMM: 21-139/145.0
YINELKKYNVSHLVRAcdpTYSTEPLQAIGIQVHDMPFADGGSPPD-AVVNNWIKILGESYKKDskETIGIHCVAGLGRAPVLVAI-ALIEGGMNPLQAV
 . .||.... ....    |. .| | . |||.. .|. | | |.. . . ...... | .|..  . . .|| ||.||...|||.  ... |... .|.
dlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllgvsleeal

EYIRERRRGSI-NIKQIQYLKNYK
|..|..|.|.. |  |...|. . 
elvrsqrpgavpnpgqlrflyefe
PTEN_1 33-160 1e-21 72.7 In-house 56-192 (196) alignment 
Range on Protein: 33-160
Range on HMM: 56-192/196.0
LPLYINELKKYNVSHLVRACD------PTYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDS-KETIGIHCVAGLGRAPVLVAIALIEG
.. . ..||. .. ..|. ..      ..|. |  .. |......|. | | |. . .  ..| . |....|. .... .|| |||||  ..||  |.. 
vaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmyk

G-MNPLQAVEYIRERR-RGSINIKQIQYLKNYKSKKK
| ... .|.|..||.| .|..|. . . |..| .. .
gkltadeAlelvrekRppgapnspsqerlleyfaell
subfamily_CDC14_pd Subfamily CDC14 35-156 1.3e-20 68.5 In-house 203-320 (328) alignment 
Range on Protein: 35-156
Range on HMM: 203-320/328.0
LYINELKKYNVSHLVRACDPTYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESykkdsKETIGIHCVAGLGRAPVLVAIALIE-GGMNPLQAV
 ...  .|.||...||     |  .  ...|.. .|. |.||. |.||.|.....|. ..     . .| .|| |||||.  |.|  |..  ...  .|.
klleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaeai

EYIRERRRGSINIKQIQYLKNYK
 ..|  | ||.  .| ..|.. .
awlricrPGsvigpqqkfleekq
0050432 (Phosphotyrosine protein) phosphatases II 14-148 3.3e-20 68.1 In-house 98-286 (308) alignment 
Range on Protein: 14-148
Range on HMM: 98-286/308.0
LVES----STHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTY------------------------------------------------STEPL
.|      ....|... .| ....  ..  . ..||.. |. .....                                                . | .
yvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesr

QAIGIQVHDMPfaDGGSPPD-AVVNNWIKILGESYkkdSKETIGIHCVAGLGRAPVLVAIALI------EGGMNPLQAVEYIRERRRGSINIKQ
.   .. .. |  |.| ||. . . ...... .|.   ....| .|| ||.||. ...|. |.      |||.....|| ..||.| |... ..
tvthfhytnWp..dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 12-147 2e-19 65.5 In-house 62-260 (284) alignment 
Range on Protein: 12-147
Range on HMM: 62-260/284.0
ASLVES-------STHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPT-----------------------------------------------YS
||.|.        ....|... .| ....  . . . ..||...|  ....                                               |.
AsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgyt

TEPLQAIGIQVHDMPfaDGGSPP-DAVVNNWIKILGESYKK-DSKETIGIHCVAGLGRAPVLVAIALIEG---------GMNPLQAVEYIRERRRGSINI
 |... . ..... |  | | ||  . . ...... |.... .....| .|| ||.||. ...|. |.           |...|.|| ..||.| |... 
gesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqt

K
 
l
0051299 (Phosphotyrosine protein) phosphatases II 18-147 2e-19 65.6 In-house 90-272 (288) alignment 
Range on Protein: 18-147
Range on HMM: 90-272/288.0
STHRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPT-------------------------------------------------YSTEPLQAIGIQV
....|... .| ....  . . . ..||.. |. ....                                                 .. |... . ...
lkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhy

HDMPfaDGGSPP-DAVVNNWIKILGESYKkDSKETIGIHCVAGLGRAPVLVAIALI------EGGMNPLQAVEYIRERRRGSINIK
.. |  | | |.    . ...... .... ... .. .|| ||.||. ...|. |.      |||...|.||...||.| |...  
tnwp..dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
0036941 (Phosphotyrosine protein) phosphatases II 16-148 9.7e-17 56.6 In-house 72-264 (297) alignment 
Range on Protein: 16-148
Range on HMM: 72-264/297.0
ESS--THRFLIFDAPNDDNLPLYINELKKYNVSHLVRACDPTY-------------------------------------------------STEPLQAI
.    ...|..  .| ....  .   . ..||...|  ....                                                  . |...  
dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvt

GIQVHDMPfaDGGSPP-DAVVNNWIKILGESYKKD-SKETIGIHCVAGLGRAPVLVAIAL---------IEGGMNPLQAVEYIRERRRGSINIKQ
 ..... |  | | |.  | . ..|. . . .|.  |.. . .||.||.||. ...|. |         .|||...|.|| ..||.| |..   .
hfhytgwp..dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtle
0051429 (Phosphotyrosine protein) phosphatases II 37-155 1.4e-15 53.2 In-house 38-220 (272) alignment 
Range on Protein: 37-155
Range on HMM: 38-220/272.0
INELKKYNVSHLVRACDPTYST---EPLQAIGIQVHDMPFADGGSPPD----------------------------------------------------
.  ||...... |  .....      .. . ||... .|. | . |.                                                     
fwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq

AVVNNWIKILGEsykkdsKETIGIHCVAGLGRAPVLVAIALIEGGMN--------------PLQAVEYIRERRRGSI-NIKQIQYLKNY
  . .....| .      .. . .|| || .|  ..||. |.  |..              ...|||..|..|.|.. .  |...| ..
eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
subfamily_PTPDC1_pd Subfamily PTPDC1 55-156 1.1e-14 49.3 In-house 72-172 (182) alignment 
Range on Protein: 55-156
Range on HMM: 72-172/182.0
TYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDskeTIGIHCVAGLGRAPVLVAIALI-EGGMNPLQAVEYIRERRRGSINIK-QIQYL
.|..| |.. || |. ....| |...   . . .|..  . ...    ...|| |||||. ||.|  |.    ... .|.. .|..|  ||. . |.. .
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelv

KNYK
|...
kefa
subfamily_CDKN3_pd Subfamily CDKN3 39-160 1.3e-13 45.0 In-house 82-196 (202) alignment 
Range on Protein: 39-160
Range on HMM: 82-196/202.0
ELKKYNVSHLVRAcdptYsteplQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKdSKETIgIHCVAGLGRAPVLVAIAL--IEGGMNPLQAVEYI
||.|| | .|.      |     |  |. ||  |.|||. |  |   . .. |  . |.  ..|. .||  ||||. ...|  |  ..  ..| .|.. .
elskyrvrrlldl....y.....qqaglivhhypiadglvpdiasclkileelrinlka.yrktl.vhcygglgrsslviaclllylddtiepkdaidkl

RERRrGS--I-NIKQIQYLKNYKSKKK
|. . ||  |  .|| .||.... |..
rdlk.gsraiqtvkqynylsefrdkle
0048567 (Phosphotyrosine protein) phosphatases II 42-153 8e-12 39.8 In-house 14-131 (157) alignment 
Range on Protein: 42-153
Range on HMM: 14-131/157.0
KYNVSHLVRACDPTYSTEPL-QAIGIQVHDMPFADGgSPPDAVVNNWIKILGESYK--KDSKETIGIHCVAGL---GRAPVLVAI-ALIEGGMNPLQAVE
.... .|.|. . .|.. ..    |.. .|. | .|  .. |.. ..|..| . .|  .  . .| .|| |||   ||. .|..  ...  |..| .|..
rlyfallprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaia

YIRERRRGSINIKQIQYLK
..|  | ||.   . .|| 
plrivrpgsvpfrdasyll
subfamily_DSP23_pd Subfamily DSP23 48-153 2.2e-10 35.3 In-house 38-139 (148) alignment 
Range on Protein: 48-153
Range on HMM: 38-139/148.0
LVRACDPTYSTEPlqaiGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKdsKETIGIHCVAGLGRAPVLVAIALI-EGGMNPLQAVEYIRERRRGSINI
|   . |   . |    .. .. .   |   |    |....... |. .|  .|....||. | ||.  ..|  |. | ..   .|.  .|..| ||.. 
lteegrphveatp....nltlvrlriddyhppaleqvvefvrvveeaeek..neavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvet

-KQIQYLK
 .| . ..
veqeklvr
subfamily_RNGTT_pd Subfamily RNGTT 52-156 6.2e-10 33.0 In-house 64-168 (189) alignment 
Range on Protein: 52-156
Range on HMM: 64-168/189.0
CDPTYSTEPLQAIGIQVHDMPFADGGS-PPDAVVNNWIKILGESYKKDSKETIGIHCVAGLGRAPVLVAIALIEGGMNPL-QAVEYIRERRRGSinIKQI
 .. | .| |.  ||. . .  |  |  |    |...||.. | .|| ..|.||.||  |  |.  |..  |.|     . .||.  .. |     |.. 
tsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppG..iyke

QYLKNYK
.|||.. 
dylkell
DSPc Dual specificity phosphatase, catalytic domain 40-156 3.1e-09 31.8 Pfam-A 14-131 (133) alignment 
Range on Protein: 40-156
Range on HMM: 14-131/133.0
LKKYNVSHLVRAC---DP--TYSTEPLQAIGIQVHDmpfaDGGSPPDAVVNNWIKILGESykKDSKETIGIHCVAGLGRAPVLVAIALIE-GGMNPLQAV
|.|..... . .    .   .....  . ..|.|.|    .  .   .  .. .... .   ....... .|| ||. | . |..  |..  ...  .|.
leklgitlvinvtkevpnnnaikkseieylripved....etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAy

EYIRERRrG--SINIKQIQYLKNYK
|...||| .  | |..... | .|.
efvkerr.skispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 40-156 3.1e-09 31.8 In-house 14-131 (133) alignment 
Range on Protein: 40-156
Range on HMM: 14-131/133.0
LKKYNVSHLVRAC---DP--TYSTEPLQAIGIQVHDmpfaDGGSPPDAVVNNWIKILGESykKDSKETIGIHCVAGLGRAPVLVAIALIE-GGMNPLQAV
|.|..... . .    .   .....  . ..|.|.|    .  .   .  .. .... .   ....... .|| ||. | . |..  |..  ...  .|.
leklgitlvinvtkevpnnnaikkseieylripved....etetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknlslneAy

EYIRERRrG--SINIKQIQYLKNYK
|...||| .  | |..... | .|.
efvkerr.skispnagflrqLleye
subfamily_PTEN_pd Subfamily PTEN 55-155 3.6e-09 31.9 In-house 72-175 (184) alignment 
Range on Protein: 55-155
Range on HMM: 72-175/184.0
TYSTEPLqaiGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKETIGIHCVAGLGRAPVLVAIALIEGGMNPLQ--AVEYIRERRR---GSINI-KQ
.|... .     .|. .|| |  .||  .... .. . .  ..|.|. . .|| || ||. ||..  |.. .. . .  |.|.  | |     .. |  |
kydskkf...dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsq

IQYLKNY
. |.. |
rRYveYy
subfamily_PTPMT1_pd Subfamily PTPMT1 56-159 5.1e-09 30.8 In-house 64-168 (171) alignment 
Range on Protein: 56-159
Range on HMM: 64-168/171.0
YSTEPLQAIGIQVHDMPFADGG-SPPDAVVNNWIKILGESykKDSKETIGIHCVAGLGRAPVLVAIALI-EGGMNPLQAVEYIRERRRG-SINIKQIQYL
 |||  .  |..   ..  |   .|  . ... .... .   ....... .|| || ||.  |||  |. .  ..| .|.......|.   .. || . |
nsteewkklgveqlqlatvDfteapdleklekgvefiekv..askgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkal

KNYKSKK
..|..| 
qeyeekl
PTPc_DSPc_SM00012 67-146 8.2e-09 31.0 In-house 4-92 (105) alignment 
Range on Protein: 67-146
Range on HMM: 4-92/105.0
QVHDMPFADGGSPPDAvvNNWIKILGESYKKDSK----ETIGIHCVAGLGRAPVLVAIALIEGG-------MNPLQAVEYIRERRRGSINI
..| .   | | | ..  .. ...| .  |. .|    . . .|| || ||. ..||....          .. .| |...|..|.|... 
hyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqt
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 61-122 1.8e-08 25.7 Pfam-A 96-155 (168) alignment 
Range on Protein: 61-122
Range on HMM: 96-155/168.0
LQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKeTIgIHCVAGLGRAPVLVAIAL
 | .||  |  | ||||.|  | . . .. |    |.  | |. |||  ||||. .. |  |
yqqygivthhhpiadggtpdiascleimeelatclknyrk.tl.ihcygglgrsclvaacll
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 61-122 1.8e-08 25.7 In-house 96-155 (168) alignment 
Range on Protein: 61-122
Range on HMM: 96-155/168.0
LQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESYKKDSKeTIgIHCVAGLGRAPVLVAIAL
 | .||  |  | ||||.|  | . . .. |    |.  | |. |||  ||||. .. |  |
yqqygivthhhpiadggtpdiascleimeelatclknyrk.tl.ihcygglgrsclvaacll
subfamily_DSP11_pd Subfamily DSP11 55-159 2.5e-08 28.0 In-house 69-174 (178) alignment 
Range on Protein: 55-159
Range on HMM: 69-174/178.0
TYSTEPLQAIGIQVHDMPFADGGSPPDAVVNNWIKILGESY--KKDSKETIGIHCVAGLGRAPVLVAIALIE-GGMNPLQAVEYIRERRrGSiNIKQIQY
 |... |.. |.. . .  .    | . .|..... . |    .||... ||.||  |. |.  |.   ||.  |..| .|.|   | | |  .. . .|
yykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear.Gh.slereny

LKNYKSKK
||. | ..
lkdLkkle
PTPc_motif_SM00404 39-155 3.9e-08 28.3 In-house 22-137 (140) alignment 
Range on Protein: 39-155
Range on HMM: 22-137/140.0
ELKKYNVSHLVRACDP---TYSTEPLQAIGIQVHDmpfaDGGSPPDAVVNNWIKILGESykKDSKETIGIHCVAGLGRAPVLVAIALIE-GGMNPLQAVE
 |||....| . . .    |....  | . |...|    .. ..  .  .. .... ..  ....... .|| ||. |   |..  |..  ...  .|.|
llkklgithvinvteevsltkensgfqilqipldd....nekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeaye

YIRERRrGSI--NIKQIQYLKNY
...|||  .|  |.. .. | .|
fvkerR.piispnlnfvrqLiey
Y_phosphatase Protein-tyrosine phosphatase 66-146 5.9e-08 27.8 Pfam-A 136-222 (235) alignment 
Range on Protein: 66-146
Range on HMM: 136-222/235.0
IQVHDMPFADGGSPpdAVVNNWIKILGESYKKD--SKETIGIHCVAGLGRAPVLVAIALIEGGMNP------LQAVEYIRERRRGSINI
 |.|     | | |  . ... .... .  |.   ... . .|| || ||. ..||. ..   ..       ||.|. .|..|.|... 
kqlhytnWpdhgvp..espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqs
Y_phosphatase Protein-tyrosine phosphatase 66-146 5.9e-08 27.8 In-house 136-222 (235) alignment 
Range on Protein: 66-146
Range on HMM: 136-222/235.0
IQVHDMPFADGGSPpdAVVNNWIKILGESYKKD--SKETIGIHCVAGLGRAPVLVAIALIEGGMNP------LQAVEYIRERRRGSINI
 |.|     | | |  . ... .... .  |.   ... . .|| || ||. ..||. ..   ..       ||.|. .|..|.|... 
kqlhytnWpdhgvp..espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqs
subfamily_DSP3_pd Subfamily DSP3 55-157 1.1e-06 22.4 In-house 57-155 (162) alignment 
Range on Protein: 55-157
Range on HMM: 57-155/162.0
TYSTEPLQAIGIQVHDMPFADGGSPPDAVvnnwIKILGESYKKdSKETIGIHCVAGLGRAPVLV-AIALIEGGMNPLQAVEYIRERRRGSINIKQIQYLK
 |.   .. .|..|.|.| .|     . .     | . |. .. ..  . .|||.|. |...|| |  .|   |.  .|.. .|..|.   |   .. |.
fykdleikylGlevdDvpefdlskyFeta....akfidealsq.kegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLa

NYKS
....
elde
subfamily_PTPN13_pd Subfamily PTPN13 97-157 4.4e-06 21.2 In-house 199-264 (273) alignment 
Range on Protein: 97-157
Range on HMM: 199-264/273.0
KDSKETIGIHCVAGLGRAPVLVAIALIEGGM------NPLQAVEYIRERRRGSINIKQiQYLKNYKS
....  | .|| ||.||. .|..|  . | .      .  . |. .||.|.| .  |. ||.  ||.
qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkd.qyifvyka
subfamily_DSP19_pd Subfamily DSP19 39-159 9.2e-06 20.1 In-house 32-150 (152) alignment 
Range on Protein: 39-159
Range on HMM: 32-150/152.0
ELKKYNVSHLVRAC-D-PTYSTEPLQAIGIQVHDMPFADGGSppdaVVNNWIKILGESYKKDskETIGIHCVAGLGRAPVLV-AIALIEGGMNPLQAVEY
.||. .. |..    . |.  .. ..   |.. | | .|  |    . .. .. . |. .||   .. .|| ||  |.. .| |  . .  ..  .|.|.
ilkekkitHilnvatgvpnvfpkdftylsieilDlpetdlls....ylkealdFieearskd..gavlvHCnAGvSRsasvviaylmkkeelsleealel

IRERRRG-SINIKQIQYLKNYKSKK
.|| |.  . |   |. ||.|....
vrearpcikPneGFikqLkeyeael