Gene DDB_G0269448 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily Ank-MTMR1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP023_AA protein Get Run
DdisP023_AA_759-1155 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 745-1147 8.5e-282 925.8 In-house 1-405 (405) alignment 
Range on Protein: 745-1147
Range on HMM: 1-405/405.0
STQPNvLNSSTSSIDGWQVYNQRREYARFNIYGDSENSG---WKFTNINKDHRMCSSYPSSLVVSNKATDKDLEKIFSFRSKGRIPTLSWKDPSSNASIS
|||.| |||||||||||.||||..||.|||||.|.|||.   ||.|.|||...|||||.|||||..||.|||||||||||||||||.|||||||||||||
stqnn.lnsstssidgwevynqkkeylrfniyideenssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasis

RCSQPLVGIERARCPEDEFYCSSLALSSPSKTLYLIDARPKINAIANTANGAGFENIHNYPNCKLIFMNIPNIHVIRKSLEKLVLAMKSSARDKDHTEST
||||||||||||||||||.||||||||.|||||||||||||.|||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
rcsqplvgierarcpedelycsslalsapsktlylidarpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtest

DMRFWGYIEETGWISHIKSILEAATFSAELILKGNSILVHCSDGWDRTPQITSLTQILLDPFYRTIHGFQVLIEKEWLSFGHKFSLRLGHLPGNEEERSP
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||.|||||||||||||||||||||||||||||||||
dmrfwgyieetgwishiksileaatfsaelilkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgneeersp

IFQQFLDCCFQLLNQFPLLFEFTPSLLLFISDNIHSCKYGTFLNNCEKDRIQNQVKTKTISIWTEVNLNVNKFLNPYFNPQDIQSIRPKLYSRCLELWKS
|||||||||||||.||||||||||||||||||||||||||||||||||||.|.||||||||||.|||||||||||||.||||||||.||||||||||||.
ifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvktktisiwsevnlnvnkflnpyynpqdiqsikpklysrclelwka

CYMRFE
||||.|
cymrve
subfamily_MTMR1_pd Subfamily MTMR1 758-1148 1.3e-137 451.2 In-house 4-388 (389) alignment 
Range on Protein: 758-1148
Range on HMM: 4-388/389.0
IDGWQVYNQRREYARFNIYGDSensGWKFTNINKDHRMCSSYPSSLVVSNKATDKDLEKIFSFRSKGRIPTLSWKDPSSNASISRCSQPLVGIERARCPE
 |||.||.  .|. |  .  .     |. |..||.. .| .||. ||| . ..|.||.|. .||||||.|.||| .....|.|.|.||||||..  |..|
edGWkvydpeaelerlgllnek...lWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrske

DEFYCSSLALSS-PSKTLYLIDARPKINAIANTANGAGFENIHNYPNCKLIFMNIPNIHVIRKSLEKLVLAMKSSARDKdhtestdmRFWGYIEETGWIS
|| | . .  .   |. |...|||...||.|| |.| | |. ..| |..|||..|.||||.|.||.||  .. ..  ||        ..   .|.| |..
dekylqaileanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvddk........kwlsalestkWle

HIKSILEAATFSAELIL-KGNSILVHCSDGWDRTPQITSLTQILLDPFYRTIHGFQVLIEKEWLSFGHKFSLRLGH--LPGNEEERSPIFQQFLDCCFQL
|||.||..|.  .| .  . .|.||||||||||| |.|||...|||..||||.||.||||||||||||||. ||||   . ...||||.| ||.|| .||
hiklilagavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwql

LNQFPLLFEFTPSLLLFISDNIHSCKYGTFLNNCEKDRIQNQVKTKTISIWTEVNLNVNKFLNPYFNPQ-DIQSIRPKLYSRCLELWKSCYMRFES
 .|||  |||. ..|... |...|| .|||| |.|| |....||.||.|.|. || . ..| ||..... . . . ||.. |.|||||. |.|...
trqfptAFefneefLitlldhlysclfGtflfnsekervkekvkektvslwsyvnsskeeftnplyaeelekkvlypkaslrrlelWkeyylrwnp
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 755-1146 2.7e-137 450.2 In-house 10-402 (404) alignment 
Range on Protein: 755-1146
Range on HMM: 10-402/404.0
TS-SiDGWQVYNQRREYARFNIYGDSensGWKFTNINKDHRMCSSYPSSLVVSNKATDKDLEKIFSFRSKGRIPTLSWKDPSSNASISRCSQPLVGIERA
.  . |||..|....||.| .| ..|    |. ..||.|...|..||. ||| .. .|..|.|..|||||||||.|||. .|.|..|.|.||||||....
svle.dgwliydaeeEykRlgikses...eWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGltks

RCPEDEFYCSSLALSSP-SKTLYLIDARPKINAIANTANGAGFENIHNYPNCKLIFMNIPNIHVIRKSLEKLVLAMKSSARDkdhtestDMRFWGYIEET
|. ||| .  |. .... ..|||..|||||.||.||.|.|||.|.|..| ||.. |.|| ||| .|.||.||  |..|. ..       .  ..  .|..
rseedEklinsirkaktqletlyildarpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiek.......eknwlseless

GWISHIKSILEAATFSAELIL-KGNSILVHCSDGWDRTPQITSLTQILLDPFYRTIHGFQVLIEKEWLSFGHKFSLRLGH-LPGNEEERSPIFQQFLDCC
.|. |||..||...  .|||  ...|.|||||||||||.|..||.|.||||.||||.||.||||||||||||||  | |.    ...|||||| ||.||.
rWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcv

FQLLNQFPLLFEFTPSLLLFISDNIHSCKYGTFLNNCEKDRIQNQVKTKTISIWTEVNLNVNKFLNPYFNPQDIQSIRPKLY--------SRCLELWKSC
.||..|||  |||  ..|. | |.. ||..|||| ..||.| ||.....|.|.|.... | ...|||..  .. .. . .           . ..||.. 
yqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleankseylnplyilekkeqkenitssessssadikliklWsey

YMRF
|.|.
ylrw
subfamily_MTMR6_pd Subfamily MTMR6 752-1147 1.5e-133 437.9 In-house 10-396 (397) alignment 
Range on Protein: 752-1147
Range on HMM: 10-396/397.0
NSSTSSIDGWQVYNQRREYARFNIygdsENSGWKFTNINKDHRMCSSYPSSLVVSNKATDKDLEKIFSFRSKGRIPTLSWKDPSSNASISRCSQPLVGIE
...... .||. .. . ||.|  .     |. |. |..|||...|..||..|.| ..|| . |     ||||||.| ||.   . .|.| |||||| |..
kdkeekvsGwklldlkaeytrmgv....pnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqplsgfs

RaRCPEDEFYCSSLALSSP-SKTLYLIDARPKINAIANTANGAGFENIHNYPNCKLIFMNIPNIHVIRKSLEKLVLAMKSSARDKDhtestdmRFWGYIE
. || |||     .  . | |..||..|.|||.||.|| |.| |.|| .|| |.|. |..| ||||.|.||.||. ... .....         |.  .|
a.rcledeklleairkanpnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvs.......eflsgle

ETGWISHIKSILEAATFSAELI-LKGNSILVHCSDGWDRTPQITSLTQILLDPFYRTIHGFQVLIEKEWLSFGHKFSLRLGHLPGNEEERSPIFQQFLDC
..||. |||..|.|..| |. .  .| |.||||||||||| |..||...||||.||||.||.||||||||||||||| | |.| ... | ||||.|||.|
ssgwlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGlldedskevsPiftqflec

CFQLLNQFPLLFEFTPSLLLFISDNIHSCKYGTFLNNCEKDRIQNQVKTKTISIWTEVNLNVNKFLNPYFNPQDI-QSIRPKLYSRCLELWKSCYMRFE
 .|||.|||  |||  . || . | ..||..|||| |||||| ....| .| |.|. .  . ...|||.....   . ..|.. . .|.||.. |.||.
vwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayllerkddylnplykaetekevlkpdtapaalklwralynrfd
0040695 (Phosphotyrosine protein) phosphatases II 758-1146 4.2e-128 421.2 In-house 5-385 (388) alignment 
Range on Protein: 758-1146
Range on HMM: 5-385/388.0
IDGWQVYNQRREYARFNIYGDsensGWKFTNINKDHRMCSSYPSSLVVSNKATDKDLEKIFSFRSKGRIPTLSWKDPSSNASISRCSQPLVGIERARCPE
..|| .|.  ||. | ..  |     |.....|... .|.|||. ||| . ..|..|.....|||||||| ||.. | ..|.. |.||||||.   |. |
eegwslydilrelkrlglgld....lwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsle

DEFYCSSLA-LSSPSKTLYLIDARPKINAIANTANGAGFENIHNYPNCKLIFMNIPNIHVIRKSLEKLVLAMkssardkdHTESTDMRFWGYIEETGWIS
|| .....  | .....|...|.|||.||.||.| | |.||...|||..|||.|||||||.|.|| ||. |.            ...... ..||.||..
deklleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac........lnvpdslnllslleesgwld

HIKSILEAATFSAELILKGNS-ILVHCSDGWDRTPQITSLTQILLDPFYRTIHGFQVLIEKEWLSFGHKFSLRLGHLPG--NEEERSPIFQQFLDCCFQL
.||.|||.| . ..|. .||| .|||||||||||.|..||.|.||||.|||. |||||||||||||||||. |||||..  . .|.||.| .|||| .||
liklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqL

LNQFPLLFEFTPSLLLFISDNIHSCKYGTFLNNCEKDRIQNQVKTKTISIWTEVNLNVNKFLNPYFNPQDIQSIRPKLYSRCLELWKSCYMRF
|.|||. |||.. ||||. | ..|| .|||| |.||.|....| ..|.|.|. .. . ..||||...|   . ..| |  ..| || ..|.|.
lrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplYdpsslevllpslsvldlllWleyylrw
Myotub-related Myotubularin-like phosphatase domain 744-1093 1.6e-120 395.1 Pfam-A 5-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 744-1093 1.6e-120 395.1 In-house 5-352 (353) alignment
subfamily_MTMR9_pd Subfamily MTMR9 757-1146 1.9e-91 299.1 In-house 11-392 (393) alignment 
Range on Protein: 757-1146
Range on HMM: 11-392/393.0
SIDGWQVYNQRREYARFNIygdsENSGWKFTNINKDHRMCSSYPSSLVVSNKATDKDLEKIFSFRSKGRIPTLSWKDPSSNASISRCSQPLVGIERARCP
. ||.. ... .|.|.         ..|. ...||....|.|||.|..| .. .|..|... .||..||.| ||. .   .| . |.||||.| .  || 
ledgysafdrenefaklis....asdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgssgkrck

EDEFYCSsLALSSPsKTLYLIDARPKINAIANTANGAGFENIHNYPNCKLIFMNIPNIHVIRKSLEKLVLAMKSSARDKDhtestdmRFWGYIEETGWIS
|||     |.|..  |  . .| | |  | .. ..|.|.|  ..|.. | .  .. ....| .|| ||. |..    ..|       .|.  .|..||.|
edeklln.lvlkkl.kkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstd.......kflsrleksgwls

HIKSILEAATFSAELILK-GNSILVHCSDGWDRTPQITSLTQILLDPFYRTIHGFQVLIEKEWLSFGHKFSLRLGHLPGNE---EERSPIFQQFLDCCFQ
... .||||.  |... . |....|| ..| | | |.|||.|..||| .||..||. |||.||.  || |. |  ..  .|   ....|.|  |||| .|
qvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyq

LLNQFPLLFEFTPSLLLFISDNIHSCKYGTFLNNCEKDRIQNQVKTKTISIWTEVNL--NVNKFLNPYFNPqDIQSIRPKLYSRCLELWKSCYMRF
.|.|||. |||  .|| ..  . .|...|||| ..|. | ....|.||.|.|. ||   ....|||| ... . . |.|     .||||.. |.|.
ilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyea.naeviwpsvapqslelWselylrw
subfamily_MTMR3_pd Subfamily MTMR3 869-1144 3e-89 292.8 In-house 170-440 (442) alignment 
Range on Protein: 869-1144
Range on HMM: 170-440/442.0
SPSKTLYLIDARPKINAIANTANGAGFENIHNYPNCKLIFMNIPNIHVIRKSLEKLVLaMKSSARDkdhtestDMRFWGYIEETGWISHIKSILEAATFS
. .|.| ..|||    |.|| | | |.|.   ||||...|....||| .|||...|   . |.. |       ...... .|.| |. ..  .|.||   
eekkkllivdarsytaafanrakgGGceleeyypncevvflglanihavrksfnslra.llsqspd.......esnwlsalektkWlqnlsvllkaavkv

AELILK-GNSILVHCSDGWDRTPQITSLTQILLDPFYRTIHGFQVLIEKEWLSFGHKFSLRLGHLPGNE--EERSPIFQQFLDCCFQLLNQFPLLFEFTP
.| . | | ..|||||||||||.||..|...||||.|||..||.||.|.|||.|||||. | || .  .  .||.|.| |.||.  || .||| .|||. 
veavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefne

SLLLFISDNIHSCKYGTFLNNCEKDRIQNQVKTKTISIWTEVNLNVNKFLNPYFNPQDIQSIRPKLYSRCLELWKSCYM
. |. .    .|| .|||| |.||.| ...||..|.|.|. .. . ... |  ..... . . |.   | |.||.  |.
aflvklvqhtysclfGtflansekereeekvkertlsvWsllrakekeyrnllykekteavllpavsvrelklwsevyl
subfamily_MTMR5_pd Subfamily MTMR5 898-1140 1.7e-57 187.3 In-house 222-476 (483) alignment 
Range on Protein: 898-1140
Range on HMM: 222-476/483.0
IHNYPNCKLIFMNIPNIHVIRKSLEKLVLAMKSSARdkdHTESTDMRFWGYIEETGWISHIKSILEAATFSAELIL-KGNSILVHCSDGWDRTPQITSLT
.. . .. .| .....|  ...|..||. |  .| .    .|..   |   .|.  |.. |.|.|. ..  ..|.  .| |.||   |||| | |..||.
sevdskaefipvelveirqvkasfkkllraClpsta...veeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvssla

QILLDPFYRTIHGFQVLIEKEWLSFGHKFSLRLGHLPGNEE-ERSPIFQQFLDCCFQLLNQFPLLFEFTPSLLLFISDNIHSCKYGTFLNNCEKDRIQNQ
|.||||.|||..||.||.|||||.|||.|. |  . . ...   .|.| ||||| .|. .|||| |||    | |..    |... ||| ..|..|....
qllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesg

V----------KTKTISIWTEVNLNVNK---FLNPYFNPQDIQSIRPKLYSRCLELWK
.          |. ..|.|  .. . ..   | |  ..|.. . .||.     |..|.
llyeekaekrakkagksvwdyidrqhkrspifynflyspdesevlrPssnvsslkvWd
subfamily_MTMR10_pd Subfamily MTMR10 781-1145 1.5e-47 154.2 In-house 23-376 (380) alignment 
Range on Protein: 781-1145
Range on HMM: 23-376/380.0
NSGWKFTNINKDHRMCSSYPSSLVVSNKATDKDLEKIFSFRSKGRIPTLSWKDPSSNASIsRCSQplVGIERARCPEDEFYCSSLALSSPSKTlylidar
. ... .. |. .  . ..|  .||.|. .|.|.|...    ..| | ..|. ....| . |.|.   .      .|.|     |. .. .         
sdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaall.rlsa..lqeaesadkekeekmlelvrkchpan.......

pkinaiantangagfenihnypNCKL--IFMNIPNIHVIRKSLEKLVL-AMKSSArdKDhTESTDMRFWGYIEETGWISHIKSILEAATFSAELI-LKGN
                      . ||  .  ..|.|. . |. .||    . ..   ..   ..| .. . .|.|.|.  .. .|. |.  ....  |..
......................dvklvdlsdelpsiqdvqkaylklreLcvidts..ee.fvtlddkwlssLektrWLayvrlclstasdavktvvekkr

SILVHCSDGWDRTPQITSLTQILLDPFYRTIHGFQVLIEKEWLSFGHKFSLRLGHLPGNEEERSPIFQQFLDCCFQLLNQFPLLFEFTPSLLLFISDNIH
|...  |.| |    . ||.|..|||.|||| ||| ||.||| . ||.|  ||||.  .|...||.|  ||||  |||.|||  ||||...|. . |  |
svilqesegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFeFtetfLialwdssh

SCKYGTFLNNCEKDRIQNQVKTKtisiwtevnlnvnkflnpyfnpqdiqsirpklysrclelwkscyM--------------------------------
|. ..||| |.|. | .. |. .                                            .                                
sgifltflfnseeqrlkavvsss............................................plliakselkendllkdeldyrqglyaeiiksi

--------------------------------R
                                |
rrlaaaksylrseiirPllqipdiqlWdeCYlR
subfamily_pats1_pd Subfamily pats1 903-1031 1.5e-25 81.7 In-house 335-459 (691) alignment 
Range on Protein: 903-1031
Range on HMM: 335-459/691.0
NCKLIFMNIPNIHVIRKSLEKLVLAMKSSardkDhtesTDMRFWGYIEETGWISHIKSILEAATFSAELILKGNSILVH-CSDGWDRTPQI---TSLTQI
 ...||...|  . ...   .|. .. |     |      .  |  |||  |.  .| .||||   . |. .|.|.|..  .|. . . ..   .||.|.
ssniiflslPtrekveerffdllqsilsl....d....gsddewkeieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqv

LLDPFYRTIHGFQVLIEKEWLSFGHKFSLRLGH
|.||||||. ||.|||||||||.|. || .  |
lsdPfyrtldGfkvliekewlsyGfPfskinyh
subfamily_MTMR3_pd Subfamily MTMR3 772-869 4.9e-23 74.6 In-house 32-129 (442) alignment 
Range on Protein: 772-869
Range on HMM: 32-129/442.0
RFNIYGDSENSGWKFTNINKDHRMCSSYPSSLVVSNKATDKDLEKIFSFRSKGRIPTLSWKDPSSNASISRCSQPLVGIERARCPEDEFYCSSLALSS
 ..  |   .. |. ...|.|...|||||. |.| .. ||.||.|  |||| .|.|.. |.  .. | . ||||| ||.   |. |||   ...| ..
everlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaedekllkaiakac
subfamily_pats1_pd Subfamily pats1 1040-1122 1.5e-18 58.6 In-house 553-635 (691) alignment 
Range on Protein: 1040-1122
Range on HMM: 553-635/691.0
SPIFQQFLDCCFQLLNQFPLLFEFTPSLLLFISDNIHSCKYGTFLNNCEKDRIQNQVKTKTISIWTEVNLNVNKFLNPYFNPQ
|||| ||||  .||  .||. |||  |||| . .. .| ..|.|| .  |.. ...|  .. |||. .| |  .|.| .. . 
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllykhs
Ank_2 Ankyrin repeats (3 copies) 123-209 5.8e-17 49.9 Pfam-A 5-86 (89) alignment 
Range on Protein: 123-209
Range on HMM: 5-86/89.0
YSNKSIKLAQLIIENGAYINHkdnkQETPLHRATmLNDNFDFLKLLLFHGANPNIVNKRGRTCQHLSIEQGKVELLELFLMYGADCS
 .|....|..|..|.|| ..     .||||| |   ..|.. .|||| .||..|  .|.|.|. || ...|..||..| | .|||..
aengnlelvklLlekgadvdl....getpLhlAa.eagnleivklLleagadvnakdkegntaLhlAvrnghlelvklLlekgadvn
Ank_2 Ankyrin repeats (3 copies) 75-145 7.4e-17 49.6 Pfam-A 22-89 (89) alignment 
Range on Protein: 75-145
Range on HMM: 22-89/89.0
DID-GYTPLHYAVNQGAFEIATKLLSRGADPNARTENGLTPLHLltkyCYSNKSIKLAQLIIENGAYINHKD
|.| | ||||.|. .| .||.  ||..|||.||....| |.|||    . .|....|..|..|.|| .| .|
dvdlgetpLhlAaeagnleivklLleagadvnakdkegntaLhl....AvrnghlelvklLlekgadvnlrd
Ank_5 Ankyrin repeats (many copies) 68-117 2.1e-14 41.4 Pfam-A 6-55 (56) alignment 
Range on Protein: 68-117
Range on HMM: 6-55/56.0
SIEVDHRDIDGYTPLHYAVNQGAFEIATKLLSRGADPNARTENGLTPLHL
.. |...|  |.||||.|...|| |.. .|| .|||.|.|...|||.|.|
padvnatdeggntpLhlAakggalevvrlLlapgadlnlrdsdgltaldl
Ank Ankyrin repeat 77-108 2.9e-13 37.2 Pfam-A 1-32 (33) alignment 
Range on Protein: 77-108
Range on HMM: 1-32/33.0
DGYTPLHYAVNQGAFEIATKLLSRGADPNART
||.||||.|.  |  |... |||.|||.||..
dGfTPLHlAalrgnlevvklLlsqGAdlnaqd
subfamily_MTMR5_pd Subfamily MTMR5 769-846 1.8e-11 35.5 In-house 13-93 (483) alignment 
Range on Protein: 769-846
Range on HMM: 13-93/483.0
EYARFNIY---GDSENSGWKFTNINKDHRMCSSYPSSLVVSNKATDKDLEKIFSFRSKGRIPTLSWKDPSSNASISRCSQP
.| |. .    | |..  .. ...||.. .| |||. .|| ..  |. ....     ..|.|   |... ..| . | ...
dykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggf
Ank_4 Ankyrin repeats (many copies) 78-117 2.3e-11 32.1 Pfam-A 1-40 (54) alignment 
Range on Protein: 78-117
Range on HMM: 1-40/54.0
GYTPLHYAVNQGAFEIATKLLSRGADPNARTENGLTPLHL
|.|.||||...|  |..  ||..|.|.|.. |.| |.||.
gltaLhyaaisgrlelvklLlekgidinrtdesGntaLhi
Ank_4 Ankyrin repeats (many copies) 127-169 5.7e-09 24.4 Pfam-A 13-54 (54) alignment 
Range on Protein: 127-169
Range on HMM: 13-54/54.0
SIKLAQLIIENGAYINHKDNKQETPLHRATmLNDNFDFLKLLL
 ..|..|..|.|. ||..|....|.||.|  |. |...|||||
rlelvklLlekgidinrtdesGntaLhiAa.lrgnieilklLl
Ank Ankyrin repeat 149-180 1.5e-08 22.3 Pfam-A 3-33 (33) alignment 
Range on Protein: 149-180
Range on HMM: 3-33/33.0
ETPLHRATMLNdNFDFLKLLLFHGANPNIVNK
.|||| | . . | . .|||| .||..|....
fTPLHlAalrg.nlevvklLlsqGAdlnaqdd
Ank_3 Ankyrin repeat 77-106 1.8e-08 22.4 Pfam-A 1-30 (30) alignment 
Range on Protein: 77-106
Range on HMM: 1-30/30.0
DGYTPLHYAVNQGAFEIATKLLSRGADPNA
.|.||||.|. .|  |..  ||..|||.||
nGnTpLhlAasngrielvkyLlengadina
Ank_5 Ankyrin repeats (many copies) 135-184 2.5e-08 22.1 Pfam-A 2-51 (56) alignment 
Range on Protein: 135-184
Range on HMM: 2-51/56.0
IENG-AYINHKDNKQETPLHRATMlNDNFDFLKLLLFHGANPNIVNKRGRT
.|.| | .|. |.. .|||| | . . . ....||| .||..|. ...|.|
lehgpadvnatdeggntpLhlAak.ggalevvrlLlapgadlnlrdsdglt
Ank_3 Ankyrin repeat 149-177 5.9e-08 20.7 Pfam-A 3-30 (30) alignment 
Range on Protein: 149-177
Range on HMM: 3-30/30.0
ETPLHRATMLNdNFDFLKLLLFHGANPNI
.|||| | . . . ...|.||..||..|.
nTpLhlAasng.rielvkyLlengadina
Ank_5 Ankyrin repeats (many copies) 171-222 8.4e-08 20.4 Pfam-A 4-56 (56) alignment 
Range on Protein: 171-222
Range on HMM: 4-56/56.0
HG-ANPNIVNKRGRTCQHLSIEQGKVELLELFLMYGADCSKPTPILPSPMEMA
|| |..|  ...|.|  || ...| .|...|.|..|||.   .    .....|
hgpadvnatdeggntpLhlAakggalevvrlLlapgadlnlrdsdgltaldlA
PTPc_DSPc_SM00012 955-1014 5.5e-07 25.1 In-house 38-71 (105) alignment 
Range on Protein: 955-1014
Range on HMM: 38-71/105.0
IshiksileaatfsaelilkGNSILVHCSDGWDRTPQITSLTQILLDPFYRTihgfqvlI
                    .....||||.|..|| ... |  .| .  ..|        
s...................skpvvVhCsaGvgRtgtfvaldillqqleket.......k
Ank_4 Ankyrin repeats (many copies) 161-202 6e-07 18.0 Pfam-A 13-54 (54) alignment 
Range on Protein: 161-202
Range on HMM: 13-54/54.0
NFDFLKLLLFHGANPNIVNKRGRTCQHLSIEQGKVELLELFL
. . .|||| .|...| ....|.|. |.... | .|.|.|.|
rlelvklLlekgidinrtdesGntaLhiAalrgnieilklLl
0045098 (Phosphotyrosine protein) phosphatases II 937-1024 9.4e-07 24.0 In-house 151-266 (278) alignment 
Range on Protein: 937-1024
Range on HMM: 151-266/278.0
HTESTDMRFWG-YIEETGWISHI--KSILEAATFSAELIL--------------KGNSILVHCSDGWDRTPQITSLTQILLD-----------PFYRTIH
 .. .   ..   ... |. |.   ||.||.  |  | .               .|. .||||| |..||  .  .  .|              ..|.  
lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR

GFQVLIEKEWLSFGHK
.....  .|.. | ..
pglavqnleqyrflye
subfamily_MTMR14_pd Subfamily MTMR14 976-1030 9.8e-07 19.9 In-house 269-329 (357) alignment 
Range on Protein: 976-1030
Range on HMM: 269-329/357.0
NSILVHCSDGWDRTPQITSLTQILLD---PFYRTIHGFQVL---IEKEWLSFGHKFSLRLG
. .||||  ||||||  .|| .. |      .....  ..|   .  .|. |||... || 
sGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrlk
Ank Ankyrin repeat 110-146 9.9e-07 16.6 Pfam-A 1-33 (33) alignment 
Range on Protein: 110-146
Range on HMM: 1-33/33.0
NGLTPLHLLTKYCysnkSIKLAQLIIENGAYINHKDN
.| |||||  ..     ... ..| ...|| .|..|.
dGfTPLHlAalrg....nlevvklLlsqGAdlnaqdd
0051429 (Phosphotyrosine protein) phosphatases II 903-1002 2.3e-06 23.0 In-house 69-177 (272) alignment 
Range on Protein: 903-1002
Range on HMM: 69-177/272.0
NCKLIFMNIPNIHVIRKSLEKLVLAMKSSARDKDHT----------ESTDMRFWGYIEETGWISHIKSIlEAATFSA----ElilkGNSILVHCSDGWDR
........|.. .. . .. .|.. . |     |..            ...| .  .  |.|. |     ||         .    |. .||||| |.||
girylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld....ggpvlvHCsaGkdR

TPQITSLTQILLDP
|  .  |  .||. 
TGtvvallllllgv
0043147 (Phosphotyrosine protein) phosphatases II 948-994 7.9e-06 21.2 In-house 72-119 (172) alignment 
Range on Protein: 948-994
Range on HMM: 72-119/172.0
YIEETGWIsHIKSILEAATFSAE--LILKGNSILVHCSDGWDRTPQITS
...  |.  ... .||.  |  |  .. .|. .||||| |..||. .  
pwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlva