Gene DDB_G0289807 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR14
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP031_AA protein Get Run
DdisP031_AA_185-347 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR14_pd Subfamily MTMR14 97-353 6.8e-115 375.7 In-house 102-357 (357) alignment 
Range on Protein: 97-353
Range on HMM: 102-357/357.0
QHYQHHDSHVEgQHDQQQAQQQSTQIRQQQAQQQLDMEHLRNNDILVIKHLNIRYICDLMVENKKKKFGFFVCSSEKVDMHRRYQDFVISSTPYPGVEFF
. ... .|  | ..|... ...  .  ..||..| .....|..|| ..|.|....|.|||||.|| |.|. |.||||.|...||.||...|.||||||||
sGlnylasgge.eadadkedeelitakedqaeeqalldrvrksdikllktlkvklivdlmvekkkvkyglavsssekadkekrykdftllslPyPGveff

ADFNRNQHCGKDLFYSWDGIEDPAELNLhPDHqLPM---IPWESYKTWDLINLTQNYFKLLLKYVSDDNNpSGLLVHCISGWDRTPLFISLLRISLWADG
..|..|... |.|||.|.  |. ||||. ||. |..   | |..||.|||..|||||.|||||||..|.. |||||||||||||||||.||||.||||||
kkfrdnkysaknlfynWkqdevdaelni.Pdk.laasvdidwseykkWdlvaltqnylklllkyvkeded.sGllvhcisGWdrtPlfvsllrlslWadg

EVHQSLKDWEMLFLTVAYDWFLFSHQLCDRAGKGEDIFYFCFYFLDFISSMDFSIHTFNK
..||||...|.|.||||||||||.|||.||  |||.|..|||..|.||.|..|||....|
lihqslsaaellyltvaydWflfghqlpdrlkkgeeilffcfdvlkfitseefsiletrk
0040695 (Phosphotyrosine protein) phosphatases II 121-352 1.6e-28 93.6 In-house 89-323 (388) alignment 
Range on Protein: 121-352
Range on HMM: 89-323/388.0
QIRQQQAQQQLDMEHLRNNDILVIKHLNIRYICDLMvenKKKKFGFFVCSSEKVDMHRRYQDFVISSTPYPGVEFFADfnrnqhcgkdlfySWDGIEDPA
 .  .. ...|. |.|.. ..  .. |.  .|.||.   .| .. ... ....|. . .|... . . ..|..... .             |.  . |  
plvglllsrsledeklleailkllpnlskllivdlr...pklnalanralgggvenedaypnaeliflnipnihvvre.............slqklldac

eLNLHPDHqLPMIPWESYKTWDLINLTQNYFKLLLKYVSddNNPSGLLVHCISGWDRTPLFISLLRISLWADgevHQSLKDWEMLfltVAYDWFLFSHQL
 ||.....   .. .|... .|||.|......|..|...  .. |..||||..|||||....||....|...   ...|. . .|   ....|..| |..
.lnvpdsl.nllslleesgwldliklilelavlivklld..lgnssvlvhcsdgwdrtsqlssLaqllldPy...YRTleGFqvL...iekeWlsfghkf

CDRAGKGED---------------------------IFYFCFYFLDFISSMDFSIH--TFN
.|| | .|.                           .| |....| |.    .|    ||.
adRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFl
0051429 (Phosphotyrosine protein) phosphatases II 137-294 1.7e-11 39.8 In-house 34-180 (272) alignment 
Range on Protein: 137-294
Range on HMM: 34-180/272.0
RNNDILVIKHLNIRYICDLMVENKKKKFGFFVCSsekvdMHRRYQDFVISSTPYPGVEFFADFNRNQHCGKDLFYSWDGIedpAELNLHPDHQLPMIPWE
  .|.  .|.|.|..|.||. |. .......         . ||  . | .. .| ....| . .....   |.| .. .      .|.. .. ... . 
taadfwrlkelgiktivdLrseeErgrlkcdryw.....pgirylhlpilddsaptilygalrvtllseellldyilrel...lltlllsagearevmhl

SYKTWDLINLTQNYFKLLLKYVSDdnnPSGLLVHCISGWDRTPLFISLLRISLWADGE
 |  |   .  |.... ||... |   .  .|||| .|.||| ... ||.. |  . |
hytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvallllllgvsle
0051082 (Phosphotyrosine protein) phosphatases II 135-288 1.5e-10 36.4 In-house 20-116 (151) alignment 
Range on Protein: 135-288
Range on HMM: 20-116/151.0
HLRNNDILVIKHLNIRYICDLMVENKKKkfgffVCSSEKVDMHRRYQDFVISSTPYPGveffadfnrnqhcgkdlfyswdgiedpaelnlhpdhqlpmip
.. . ..  .|.|.|..|..|. |   .      | .   .. ... .. | ..| ||                                          
gpladflellkelgiktivnlrseeerg.....ycpeylpelgievlhipildwpdpg..........................................

wesyktwdlINLTQNYFKLLLKYVSDdNNPSGLLVHCISGWDRTPLFISLLRIS
         . |... .. .|... | ...  .|||| .|..|| ... |... 
.........lplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylml
0049772 (Phosphotyrosine protein) phosphatases II 146-292 1.7e-09 33.3 In-house 91-242 (314) alignment 
Range on Protein: 146-292
Range on HMM: 91-242/314.0
HLNIRYICDL------------MVENKKKKFGFFVC---------------------SSEKVDMHrryqdfvisstPYPGVEFFADFNrnqhcgkdlfys
. .  ...|.            ||.. . ..   |.                       .    .           ..| .. .....            
gpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk............

wdGIEDPAELNLHPDHQLPMIPWESyKTWDLINLTQNYFKLLLKYvsddNNPSGLLVHCISGWDRTP--LFISLLRISLWAD
  .. ...||  ..  ..  ||..   ...|..  .  .......    .... .|||| .|..||.  ... .| . |. .
..eelydpelferlgikylripvpD.gsaplledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkllgvs
0040439 (Phosphotyrosine protein) phosphatases II 135-287 3.5e-09 32.1 In-house 65-202 (249) alignment 
Range on Protein: 135-287
Range on HMM: 65-202/249.0
HLRNNDILVIKHLNIRYICDLMVENKK--------------KKFGFFVCSSEKVDMHRRYQDFVISSTPYPgveffadfnrnqhcgkdlfyswdgiedpa
.  ....  ...|.|..|..|. .  .              ...| |.    .|...  |  ...  |..                              
etvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnly.............................

ELNLHPDHQLPMIPWESYKTWDLINLTQNYFKLLLKYVSDDNNPSGLLVHCISGWDRTPLFISLLRI
. . .  .......|  ... . .. . .......|......... .||||  | .||..|| .. .
dgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm
0042113 (Phosphotyrosine protein) phosphatases II 139-287 1.7e-08 29.7 In-house 67-199 (245) alignment 
Range on Protein: 139-287
Range on HMM: 67-199/245.0
NDILVIKHLNIRYICDLMVENKKKKFGFFVCSSEkvDMHRRYQDFVISSTPYPGvefFADFNRNQHCGKDLfyswdgiedpAELNLHPDHQLPMIPWESY
. .  ...|.|..|..|. |  ... ...   ..  . . .| ||..  . .     ..|. . . . ..|           .   . ....  .||. .
dfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtllseeh...lddytvrtlevtnl..........gddesrevihyhylpwpdh

KTWDLINLTQNYFKLLLKYVSDdNNPSGLLVHCISGWDRTPLFISLLRI
.. ||..| .. .....|.... ...  .||||  | .|| .|| ....
gvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylm
0036282 (Phosphotyrosine protein) phosphatases II 140-288 2.7e-08 29.2 In-house 28-128 (174) alignment 
Range on Protein: 140-288
Range on HMM: 28-128/174.0
DILVIKHLNIRYICDLMVENKKKKFGFFVCSSEkvdmhrryqdfvisstpypgveffadfnrnqhcgkdlfyswdgiedPAELNLHPDHQLPMIPWESYK
..  .|.|.|... .|. |. .......   .|                                                |   . ..|.  .||. . 
fwemlkelgittvvmlleekelglykcinywpe..............................................lredlerlgiqylylpwpDhg

TWDLINlTQNYFKLLLKYVSDdNNPSGLLVHCISGWDRTPLFISLLRIS
. ||    .. .|.. ...|. ..   .||||  | .||.... .... 
vpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylml
0044763 (Phosphotyrosine protein) phosphatases II 139-284 3.8e-08 28.7 In-house 39-130 (178) alignment 
Range on Protein: 139-284
Range on HMM: 39-130/178.0
NDILVIKHLNIRYICDLMVENKKKKFGFFVCSSEKVDmhrryqdfvisstpypgveffadfnrnqhcgkdlfyswdgiedpaelnlhpdHQLPMIPWESY
.|.  .| |.|..|..|  |    ... .    |. .                                                     |   ||.. .
ddlellkelgithivnlteelelgflkcdpywpeeag....................................................iqylhipipDh

KTWDLINLTQNYFKLLLKYVSddNNPSGLLVHCISGWDRTPLFISL
.. ||.  ... .... ....  ....  ||||  |..|..... .
gvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaa
0048179 (Phosphotyrosine protein) phosphatases II 139-287 4.3e-08 28.5 In-house 20-106 (144) alignment 
Range on Protein: 139-287
Range on HMM: 20-106/144.0
NDILVIKHLNIRYICDLMVENKKKKFGFFvcssekvdmhrryqdfvisstpypgveffadfnrnqhcgkdlfyswdgiedpaelnlhpDHQLPMIPWESY
.|.  .|.|.|.....|. |  .  ....                                                            .|.  .||. .
ldlellkklgittvinlteeyepeflere...........................................................giqylhlpwpDh

KTWDLINLTQNYFKLLLKYVSddnNPSGLLVHCISGWDRTPLFISLLRI
 . ||..| .. .... ....   ..   ||||  | .||.... . ..
gvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaaylm
0045450 (Phosphotyrosine protein) phosphatases II 142-288 4.4e-08 28.7 In-house 125-258 (307) alignment 
Range on Protein: 142-288
Range on HMM: 125-258/307.0
LVIKHLNIRYICDLMVENKKK---------------KFGFFVCSSEKVDMHRRYQDFVISSTPY--PGveffadfnrnqhcgkdlfyswdgiedpaelNL
  ........|..|. .  ..                .| |.    ... .  |. ...  |..   |                              . 
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtg..............................es

HPDHQLPMIPWESYKTWDLINLTQNYFKLLLKYVSDDNNPSGLLVHCISGWDRTPLFISLLRIS
.  ...... |  ... . .. . . .....|.........  ||||  | .||. || .. . 
rtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylml
0046846 (Phosphotyrosine protein) phosphatases II 132-289 2e-07 26.4 In-house 31-134 (176) alignment 
Range on Protein: 132-289
Range on HMM: 31-134/176.0
DMEHLRNNDILVIKHLNIRYICDLMVENKKKKFGFFVCSSEKVDMHRryqdfvisstpypgveffadfnrnqhcgkdlfyswdgiedpaelnlhpdhQLP
....   ...  .|.|.|... .|. |  .......   .|  ...                                                   |  
plprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..................................................qyl

MIPWESYKTWDLiNLTQNYFKLLLKYVSDDnnpSGLLVHCISGWDRTPLFISLLRISL
 .||. . . || .| .. .... ......      ||||  |  ||.... .. . |
hlpwpDhgvpdl.elllellefirealkeg...gpvlVHCsaGigRtgtlvaayllel
0043336 (Phosphotyrosine protein) phosphatases II 173-287 2.8e-07 25.8 In-house 80-233 (278) alignment 
Range on Protein: 173-287
Range on HMM: 80-233/278.0
KVDMHRRYQDFVISSTPY------------------------------------------------------------------------Pgveffadfn
 ||.... ..|.....|                                                                         .         
yvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdg.........

rnqhcgkdlfyswdgiedpaelNLHPDHQLPMIPWESYKTWDLINLTQNYFKLLLKYVSddNNPSGLLVHCISGWDRTPLFISLLRI
                      . .  ...  ..|  ... . ..| ... | ......  .... .||||  | .|| .|| |...
......................esrtvthyhylgwpdhgvpeslsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyll
0039614 (Phosphotyrosine protein) phosphatases II 225-287 3.4e-07 25.5 In-house 183-245 (297) alignment 
Range on Protein: 225-287
Range on HMM: 183-245/297.0
HPDHQLPMIPWESYKTWDLINLTQNYFKLLLKYVSDDNNPSGLLVHCISGWDRTPLFISLLRI
.  ...  ..|  ... ....| .. ..|. .... ....   ||||  | .||  || ....
rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylm
0045098 (Phosphotyrosine protein) phosphatases II 133-288 3.6e-07 25.3 In-house 73-230 (278) alignment 
Range on Protein: 133-288
Range on HMM: 73-230/278.0
MEHLRNNDILVIKHLNIRYICDLM--VENKKKKFGFFVCSsekvDMHRRYQDFVISSTPYpgveffadfNRNQHCGKDLFYSWDGIEDPAELNLHPDHQL
...  ....  ...|.|..|. |.  ||....|.  .  .    . . .| ||..  . .          ....  .  .. ..    ...|  .  ..|
lpstvadfwrmlwelgitvivmltelvelgrekcaqywpe....ggsltygdftvtllse.........evlddytlrtllvtnltveredlesrgvthl

PMIPWESYKTWDLI--NLTQNYFKLLLKYVS-----------DDNNPSGLLVHCISGWDRTPLFISLLRIS
 ..||. . . .|   .  ..... ......            ....   ||||  |..||  .. .  . 
hylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylml
0037934 (Phosphotyrosine protein) phosphatases II 138-290 4.8e-07 25.1 In-house 58-204 (243) alignment 
Range on Protein: 138-290
Range on HMM: 58-204/243.0
NN----DILVIKHLNIRYICDLMVENKKKKFGFFVCSSEKVdMHRRYQDFVISS-------------TpypgveffadfnrnqhcgkdlfyswdgI----
..    ..  ...|.|..|..|. .  ..... .   ...| .. ...  ..|.             .                                
eddlasfwrmlwelgitvivmltelvElgrekcaqywpgev.tygdftvtllseehlddytvrtllle...........................nldld

--EdpaelnlHPDHQLPMIPWESYKTWDLINLTQNYFKLLLKYVSD------DNNPSGLLVHCISGWDRTPLFISLLRISLW
  .       . ....  .||  ... | ..  ..... . .....      ... . .||||  | .|| ..| .. . | 
dlt.......rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmlll
0043147 (Phosphotyrosine protein) phosphatases II 135-287 5.1e-07 25.1 In-house 31-123 (172) alignment 
Range on Protein: 135-287
Range on HMM: 31-123/172.0
HLRNNDILVIKHLNIRYICDLMvENkkkkfgffvcssekvdmhrryqdfvisstpypgveffadfnrnqhcgkdlfyswdgiEDPAELNLHPDHQLPMIP
.  . ..  .|.|.|..| .|. |                                                          . ..||  . . |.  .|
ntladfwrmlkelgithivnlt.el.........................................................lydpellerlgiqylylp

WESYKTWdLINLTQNYFKLLLKYVsDDNNPSGLLVHCISGWDRTPLFISLLRI
|. . .  |..| .. .... ...   ..    ||||  |..||.... .. .
wpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylm
0048076 (Phosphotyrosine protein) phosphatases II 140-286 6.1e-07 24.8 In-house 21-103 (145) alignment 
Range on Protein: 140-286
Range on HMM: 21-103/145.0
DILVIKHLNIRYICDLmvenkkkkfgffvcssekvdmhrryqdfvisstpypgveffadfnrnqhcgkdlfyswdgiEDPAELNLHPDHQLPMIPWESYK
|.  .|.|.|... .|                                                              .  ||  . . |.  .||. . 
dlellkdlgittvlnl.............................................................tselellerlgiqylylpwpDhg

TWDLINLTQNYFKLLLKYVSDDnnpSGLLVHCISGWDRTPLFISLLR
. ||..| .. .... ......      ||||  | .||.... .  
vpdllellleflefieealkeg...gpvlVHCsaGvgRtgtlvaayl
0049260 (Phosphotyrosine protein) phosphatases II 139-287 6.4e-07 24.7 In-house 24-112 (152) alignment 
Range on Protein: 139-287
Range on HMM: 24-112/152.0
NDILVIKHLNIRYICDLMVENKKKK--FGFFVcssekvdmhrryqdfvisstpypgveffadfnrnqhcgkdlfyswdgiedpaelnlhpdhQLPMIPWE
...  .|.|.|..|  |. .  ..|  . .                                                              |   .||.
dfwrmlkelgittivmltellelgklkceqyi............................................................qylhlpwp

SYKTWDLINLTQNYFKLLLKYvsDDNNPSGLLVHCISGWDRTPLFISLLRI
 . ..||. | .  .... |.    ..    ||||  | .||.... .. .
Dhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylm
0041856 (Phosphotyrosine protein) phosphatases II 137-284 4.8e-06 21.8 In-house 47-129 (182) alignment 
Range on Protein: 137-284
Range on HMM: 47-129/182.0
RNNDILVIKHLNIRYICDLMvenkkkkfgffvC----SsekvdmhrryqdfvisstpypgveffadfnrnqhcgkdlfyswdgiedpaELNLHPDHQLPM
 ....  .|.|.|..| .|             .                                                       ||  .  .|.  
vadflrmlkelgittivnlt............eelywp..................................................ellerlgiqyly

IPWESYKTWDlINLTQNYFKLLLKyvsddnNPSGLLVHCISGWDRTPLFISL
.||. . . | .. . .. .  |.      ..   ||||  | .||. .. .
lpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaa