Gene pats1 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily pats1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP032_AA protein Get Run
DdisP032_AA_839-1355 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_pats1_pd Subfamily pats1 938-1223 1e-110 363.2 In-house 221-464 (691) alignment 
Range on Protein: 938-1223
Range on HMM: 221-464/691.0
NSSSSNLANNNNSNNNNINN--------------NNNNNNNNNNNNNNNSNNNNNNNNNNNNNNNNNNNNNGGGSGSRSTTIDNGQTSILNKNISNTpli
.||||.|....||..||.|.              |...|||||||||||||||||||||||||||||||||...|.|.....||..|..|.|..|.|   
sssssslstslnsssnnlnkefqqihqqmqqnqlnsssnnnnnnnnnnnsnnnnnnnnnnnnnnnnnnnnnnnnsnskinkrdneativltkkvsgt...

qsptpnlppSQHSLNLlmspqtssprihqsissssipqvcqedidflrgildiksssmLNVFDtgsggsySSTMIGCQIEFLNLPPPNKVRERFNRLLH-
         |..||||                                          |.|..       |..||...|.||.||...||.|||..||. 
.........sdnslnl..........................................lsvye.......sfkmissniiflslPtrekveerffdllqs

-LHLGNPDSEWSETIRFFWLDPLKPILSAAINIAMHVDQGRSVLIQNSSSGPDIELQL---SSLAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHH
 |.|...|.||.|.....|.|..|..|.||.......|.|.|||..||...|.|||.|   |||||.|.||.|||.|||||||||||||||.||||...|
ilsldgsddewkeieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkvliekewlsyGfPfskinyh

KTSDD
|.|||
kesdd
0040695 (Phosphotyrosine protein) phosphatases II 848-1351 1.8e-82 271.0 In-house 13-385 (388) alignment 
Range on Protein: 848-1351
Range on HMM: 13-385/388.0
LLQEYNRIGVSWDLWRTTTQS---KLCEHYPPTSVVPKSVSDNIVVTSAYYRSYG-FPVLAWSHPTQKSSITRATSPEDqnngssnylltpnspnssssn
 |.|..|.|...|||| ..     .||..||.  |||||.||.... .| .||.| .||| ..||. .....|   |                       
ilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplv.....................

lannnnsnnnninnnnnnnnnnnnnnnnnsnnnnnnnnnnnnnnnnnnnnngggsgsrsttidngqtsilnknisntpliqsptpnlppsqhslnllmsp
                                                                                                    
....................................................................................................

qtssprihqsissSSIPQVCQEDIDFLRGILD-IKSSSMLNVFDT------------GSGGSYSSTMIGCQIEFLNLPPPNKVRERFNRLLHLHLGNPDS
             . . . ..|| ..|. ||. ....|.| ..|.            |.|  . .... ... |||.|  . ||| ...||.. |..|||
.............glllsrsledeklleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldaclnvpds

EwseTIRFF-----WLDPLKPILSAAINIAMHVDQGRS-VLIQNSSsGPDIELQLSSLAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHH---KTS
     .. .     ||| .| ||..|..|. ..|.| | ||...|. | |.  |||||||.||||||||..|| |||||||||.|..|..|..|    ..
l...nllslleesgwldliklilelavlivklldlgnssvlvhcsd.gwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseid

DDGFSPIFMQFIFLVWQIWKEFPTHFQFNEYYLLTLLDNVYNSRFGTFLCNNYKERMENNVYSSTKSFWSFQQQNQSRFTNLFYRPSPssssssssssss
...|||.|..|.  |||... |||.|.|||..||.|.| .| .||||||.|. |||.|..|...| |.||. ....|.|.|..| ||.            
skefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplYdpss............

lsngynsSVQHLKCLRVFQDTMWNEYFFRY
       ....|. |.|.. ..|.||..|.
.......levllpslsvldlllWleyylrw
subfamily_pats1_pd Subfamily pats1 1224-1352 3.2e-66 216.1 In-house 551-689 (691) alignment 
Range on Protein: 1224-1352
Range on HMM: 551-689/691.0
GFSPIFMQFIFLVWQIWKEFPTHFQFNEYYLLTLLDNVYNSRFGTFLCNNYKERMENNVYSSTKSFWSFQQQNQSRFTNLFYRPSpSSSSSSSSSSSSLS
.|||||.||..||||..||||.||.|||..||.|......||||.||....|...|..|....||.|||..||.|||.||.|..| .||||||||||.||
sfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllykhs.asssssssssskls

NGYNSSVQHLKCLRVFQD-----------TMWNEYFFRYC
....|.|..||.|..|..           ..|.|.|....
spissrvsflkkledfnemikpscdndqiilwsefftefi
Myotub-related Myotubularin-like phosphatase domain 830-1279 6e-66 215.6 Pfam-A 7-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 830-1279 6e-66 215.6 In-house 7-352 (353) alignment
subfamily_MTMR1_pd Subfamily MTMR1 1086-1308 5.3e-65 212.2 In-house 132-361 (389) alignment 
Range on Protein: 1086-1308
Range on HMM: 132-361/389.0
D--TGSGGSYSSTMIGCQIEFLNLPPPNKVRERFNRLLHLHL-GNPDSEWSETIR-FFWLDPLKPILSAAINIAMHVDQGRSVLIQNSSSGPDIELQLSS
.  .| |   ...   ... ||...  . ||| ...| .| |    |..|  ..    ||. .| ||..|..|. .|.. ..  .   | | |   || |
nkakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDRtaqlts

LAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHH---KTSDDGFSPIFMQFIFLVWQIWKEFPTHFQFNEYYLLTLLDNVYNSRFGTFLCNNYKERM
||..|||.||||..||.|||||||||.|..|..|  |   ..||.  ||.|.|||  |||. . ||| |.||| .|.||||..|...|||||.|. |||.
LamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfnsekerv

ENNVYSSTKSFWSFQQQNQSRFTNLFYRPS
...|...| |.||. ......||| .|...
kekvkektvslwsyvnsskeeftnplyaee
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1073-1351 6.6e-64 208.5 In-house 129-402 (404) alignment 
Range on Protein: 1073-1351
Range on HMM: 129-402/404.0
ILDIKS-SSMLNVFDTGSGGSYSSTMIGCQIEFLNLPPPNKVRERFNRLLHLHLGNPDS--EWSETIR-FFWLDPLKPILSAAINIAMHVD-QGRSVLIQ
|||...  .  .  ..|.| .  |.  .|.|||||.   ...|| ...| ..   . ..  .| . .    ||| .| .|... .|. ... .. |||..
ildarpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiekeknwlselessrWldhiklllegskriveliekekssvlvh

nSSSGPDIELQLSSLAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHH--KTSDDGFSPIFMQFIFLVWQIWKEFPTHFQFNEYYLLTLLDNVYNSR
  | | |   |||||.|.||||||||. ||.|||||||||.|  | .|. .  ..|.| .||||.|||  |.|. | |||.|.||| .|...||..|..|
.csdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscr

FGTFLCNNYKERMENNVYSSTKSFWSFQQQNQSRFTNLFYRPSPSSSSSSSSSSS-SLSNgynssvqhlkclRVFQDTMWNEYFFRY
|||||... ||| .||... |.|.|.  ..|.| . | .|  . . .... .||. |.|.             . . ..|.||..|.
fgtFLydsekeRqqnnlaketvslWalleankseylnplyilekkeqkenitssessssa............dikliklWseyylrw
subfamily_MTMR3_pd Subfamily MTMR3 1088-1308 7.6e-58 189.3 In-house 193-418 (442) alignment 
Range on Protein: 1088-1308
Range on HMM: 193-418/442.0
GSGGSYSSTMIGCQIEFLNLPPPNKVRERFNRLLHLHLGNPDS-EWSET-IRFFWLDPLKPILSAAINIAMHVDQ-GRSVLIQnSSSGPDIELQLSSLAQ
| |  ..     |...||.|.    ||. || | .|    ||. .|  .     ||  |  .| ||.... .||. ||.||.   | | |   |. .||.
gGGceleeyypncevvflglanihavrksfnslrallsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvh.CsdGWdrttqivalak

ILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHHKTS-D--DGFSPIFMQFIFLVWQIWKEFPTHFQFNEYYLLTLLDNVYNSRFGTFLCNNYKERMENN
.||||||||..|||||.|.|||..|. |. || |.   |  .  .|.|.|.. .| |. ..||| |.||| .|. |.   | . |||||.|. ||| |..
llldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeek

VYSSTKSFWSFQQQNQSRFTNLFYRPS
|.. | | ||. .... ...|| |...
vkertlsvWsllrakekeyrnllykek
Pkinase_Tyr Protein tyrosine kinase 2248-2511 7.5e-55 175.7 Pfam-A 2-259 (259) alignment 
Range on Protein: 2248-2511
Range on HMM: 2-259/259.0
MIEELIGEGGAALVYRARWQ------GQTVAVKKLKTienldspieindISLSKAFNEFRRECWVMSELEHPNIVQLKGLCL--DPLCIVTEYLPHGNLY
 ... .|||  . |......       ..||||.||              . ... .|| .|  .|..|.|.|||.| |.|.  .||.|||||...|.|.
elgkklGeGafGeVvegtlkgekekkevkVavKtlke............eaeeeekeefleeakimkklkhenivkllgvctkeepllivteyvegGdLl

SFLHKP-EMEFSWLFRLKVALDISSGMAFLHSSTppIIHRDLKSPNILLASinenaQTIAKVVDFGLSGLQ-----HTITNRGVENPLWLAPEILNKTKe
.||.|  . ...   .|..||.|..||..|.| .  ..|||| . |.||..     ....|. ||||.         . ....  .  |.|||.|...| 
kfLrkkekekltledllsfalqiAkGmeyLeskk..lvHrdLaarNvLlee.....nkvvkisDfGLardiekddyykkkekaklpvkWmapEslkekk.

ASTQTDVYAFGVILWELVTRK-DYFGEIgFMTLIEEKVINGERPKIPEDCPEMYSKLIVECWQTDASQRPKFSEIEDRL
 ....||..|||.|||..|   . . ..   . . ||. .|.| . ||.|||   .|. .||......||.|.|. ..|
ftsksDvWsfGvllwEiftlgespypgl.sneevleklkegkrlekpencpeelyelmkqCweeepekRptfkelvekl
subfamily_MTMR6_pd Subfamily MTMR6 1103-1310 2.2e-54 177.2 In-house 161-372 (397) alignment 
Range on Protein: 1103-1310
Range on HMM: 161-372/397.0
EFLNLPPPNKVRERFNRLLHLH-LGNPD-SEWSETI-RFFWLDPLKPILSAAINIAMHV-DQGRSVLIQnSSSGPDIELQLSSLAQILLDPYYRTMDGFK
.|...     .||  ..||.   | ... ||. ...    ||  .| .| |.| ||  | ..| |||.   | | |   |  |||..||||||||..||.
qfvgienihvmreslqkllevvelksksvseflsglessgwlkhikavldasifiakavaeegasvlvh.csdGwdrtaqvcslasllldpyyrtikGfl

VLIEKEWLSYGYPFSKRCHHKTS-DDGFSPIFMQFIFLVWQIWKEFPTHFQFNEYYLLTLLDNVYNSRFGTFLCNNYKERMENNVYSSTKSFWSFQQQNQ
|||||||||.|. ||.|| .  .    .||||.||.  |||. . ||. |.||| .||.| | || ..|||||.|. |.| ....   ||| |.. ....
vliekewlsfGhkfsercGlldedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayllerk

SRFTNLFYRPSPS
. ..| .|... .
ddylnplykaete
subfamily_MTMR5_pd Subfamily MTMR5 846-1288 2.3e-52 170.4 In-house 8-425 (483) alignment 
Range on Protein: 846-1288
Range on HMM: 8-425/483.0
HSLLQEYNRIGVS----------WDLWRTTTQSKLCEHYPPTSVVPKSVSDN-IVVTSAYYRSYGFPVLAWSHPTQKSSITRATSPEDQNngSSNYLLTP
.. .|.|.|.|.           . . .  .. ..|. ||   |||..|||. |   .  .|   .||  | |. .|. . |....| ..    . | . 
rayvqdykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskg..vvgllksa

NSPNSSSSNLANNNNSNNNN------INNNNNNNNNNNNNNNNNSN--NNNNNNNNNNNNNNNNNNNNGGGSGSRSTTIDNGQTSIlnknisntpliqsp
|...|| |.  .. .| . .      .|.  .... . |.. . |    ........... ....|.   ... .... ..|.|                
ntqgsstsessessksleqekylkavvnevsklsalalnsslevslsvlasssssdkraalsteknaldisksdkasqggkgatlk..............

tpnlppsqhslnllmspqtssprihqsissssipqvcQEDIDfLRGILDIKSSsMLNVFDTGSG--GSYSSTMIGCQIEFLNLPPPNKVRERFNRLLHLH
                                     ...       | ..    | |.   |   .  | .   ...  ..|.   .|.  |..||.  
.....................................ennak.eskklrarka.aLYvlgeksqlknvksevdskaefipvelveirqvkasfkkllraC

LGNPDSEWSETIRFF-------WLDPLKPILSAAINIAMHVD-QGRSVLIQNsSSGPDIELQLSSLAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRC
| . ..| .|.  |        ||  .. .|  .  ..  .| || |||.     | |.  |.|||||.||||||||..|||||.|||||..|. |.||.
lpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvsl.EdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrs

HHKTSDD--GFSPIFMQFIFLVWQIWKEFPTHFQFNEYYLLTLLDNVYNSRFGTFLCNNYKERMENNVYSSTKS
....|    ||.|.|.||.  |.|. . ||. | ||..|| .|       || ||| .  .||.|...  . | 
nqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeeka
subfamily_MTMR9_pd Subfamily MTMR9 1073-1309 5.2e-49 159.3 In-house 124-370 (393) alignment 
Range on Protein: 1073-1309
Range on HMM: 124-370/393.0
ILDIKSSSMLNVFDTGSGGS-YSSTMIGCQIEFLNLPPPNKVRERFNRLLH--LHLGNPDSEWSETI-RFFWLDPLKPILSAAINIAMHVDQGRSVLIQN
|.|..|.|. .   .  ||   ... .  . .  .|  .... . . .||.   ..|   ... . . .  ||. .. .|.|| ..|  .|.  ....  
ivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvh

SSSGPDIELQLSSLAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHHKT----SDDGFSPIFMQFIFLVWQIWKEFPTHFQFNEYYLLTLLDNVYNS
 ..| |. ||..||||..|||..||..||. |||.||.  | ||..|... .    ...  .|.|. |.  |.|| . ||  | ||| .| .|  . | |
geeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyss

RFGTFLCNNYKERMENNVYSSTKSFWSFQQ--QNQSRFTNLFYRPSP
.||||||.| .|| |... . |.|.||. .  .. ..|.|..| .  
qfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyeana
Pkinase Protein kinase domain 2249-2507 2e-46 148.2 Pfam-A 3-254 (260) alignment 
Range on Protein: 2249-2507
Range on HMM: 3-254/260.0
IEELIGEGGAALVYRARWQGQT--VAVKKLKTIENLDSPiEINDISlskafnefrrECWVMSELEHPNIVQLKGLCL--DPLCIVTEYLPHGNLYSFLHk
..| .|.|. . ||.|.....   ||||.||. |. ..  |.....          |. .. .|.|||||.| ...   | |..|.||...|.|...|. 
lleklGsGsfGkVykakekktgkkvAvKilkkeeekskk.ektalr..........ElkilkklnHpnivkllevfeekdelylvleyveggdlfdllk.

PEMEFSWLFRLKVALDISSGMAFLHSStpPIIHRDLKSPNILLASINENaqtiaKVVDFGLSG---LQHTITNRGVENPLWLAPEILNKTKEASTQTDVY
 .  .|.    |.|| | .|...|||    |||||||. |||| . .|      |..||||.     ... ..  |  . ..|||.|.| ||.... ||.
kkgklseeeikkialqilegleylHsn..giiHrDLKpeNiLldekgel.....kiaDFGlakkleksseklttlvgtreYmAPEvllkakeytkkvDvW

AFGVILWELVTRKDYFGEI---GFMTLIEEKVINGERPKIPEDCP--EMYSKLIVECWQTDASQRPKFSEI
..||||.||.|.|  | .      . ||...  .  . ..|....  |.  .|| .....|...|... ||
slGvilyelltgklpfsgeseedqlelirkilkkkleedepkssskseelkdlikkllekdpakRltaeei
subfamily_MTMR10_pd Subfamily MTMR10 1140-1351 6.8e-40 129.0 In-house 164-377 (380) alignment 
Range on Protein: 1140-1351
Range on HMM: 164-377/380.0
WLDPLKPILSAAINIAMHV-DQGRSVLIQNsSSGPDIELQLSSLAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHHKTSDDG-FSPIFMQFIFLVW
||.  . .|| |....  | ...|||..|. |.| |. . ..||||..|||.|||..||. ||.||| . |.|| .|. | .....  ||.|. |  .|.
WLayvrlclstasdavktvvekkrsvilqe.segrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvd

QIWKEFPTHFQFNEYYLLTLLDNVYNSRFGTFLCNNYKERMENNVYSSTKSF-WSFQQQNQSRFTNLFYRPSPSSSSSSSSSSSSLSNGYNSSVQHLKCL
|  . ||. |.|.| .|..|.| .. . |.|||.|. ..|... | ||      |....|.. . .|.|| .    .  |    . .. |  |      |
qlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsssplliakselkendllkdeldyrqglyaeiiksirrlaaaksylrseiirPll

RVFQDTMWNEYFFRY
.... ..|.| ..|.
qipdiqlWdeCYlRW
subfamily_pats1_pd Subfamily pats1 838-915 2.2e-35 114.2 In-house 1-81 (691) alignment 
Range on Protein: 838-915
Range on HMM: 1-81/691.0
GNTECFPDHSLLQEYNRIGVSWDL-WRTTT--QSKLCEHYPPTSVVPKSVSDNIVVTSAYYRSYGFPVLAWSHPTQKSSIT
..||.|...|||.|..|.....|. ||...  ...|.|.||....|||.|||...|.....||...|||.||....|||. 
ytteifdiyslliegqrlkldldkdwrvveflsrdlseiyPkrilvPklvsdellvsyvrkrsskiPvlswsnqnnksslf
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 946-1309 1.8e-29 94.7 In-house 4-381 (405) alignment 
Range on Protein: 946-1309
Range on HMM: 4-381/405.0
NNNNSNNNNINNNNNNNNNNNNNNNNNSNNNNNNNNNNNNNNNNNNNNNGGGSGSRSTTIDNGQT-SILNKNISNTPLI--QSPTPNLPPSQHSLNLLMS
|| ||... |.  .  |....    |   ...|..|   .  . |.. .   | | |  . .  .   |.| .|        | . . | |. |.     
nnlnsstssidgwevynqkkeylrfniyideenssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsq

PQTSSPRIH---QSISSSSIPQVCQEDIDFLrgildIKSSSMLNVF-D--TGSGGSYSSTMIGCQIEFLNLPPPNKVRERFNRLLH-LHLGNPDSEWS--
|     | .   . .  ||.   .     .|     | .   || . .   |.|         |.. |.|.|    .|  ...|   ..    | . .  
plvgierarcpedelycsslalsapsktlyl.....idarpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtes

ETIRFF-------WLDPLKPILSAAINIAMHVDQGRSVLIQnSSSGPDIELQLSSLAQILLDPYYRTMDGFKVLIEKEWLSYGYPFSKRCHHK-TSDDGF
  .||.       |.  .| || ||   |  . .| |.|..  | | |   |..||.||||||||||. ||.|||||||||.|. || |  |    ..  
tdmrfwgyieetgwishiksileaatfsaelilkgnsilvh.csdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgneeer

SPIFMQFIFLVWQIWKEFPTHFQFNEYYLLTLLDNVYNSRFGTFLCNNYKERMENNVYSSTKSFWSFQQQNQSRFTNLFYRPSP
|||| ||.  ..|. ..||  |.|    || . ||..  ..|||| |  |.|....|   | | ||  . |  .| | .| |  
spifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvktktisiwsevnlnvnkflnpyynpqd
Miro Miro-like protein 1724-1857 6.2e-17 48.7 Pfam-A 1-119 (119) alignment 
Range on Protein: 1724-1857
Range on HMM: 1-119/119.0
KLMIVGQENVGKTTLLKTLKEKKKKatpsgpnistdgiaidqwvFSCLFEELDET--------------SqngrlikkkqditLSIWDFAGQEIYYTTHQ
|...||...|||..||. | .....                    . | || ...              .             |..||..|.|. . .|.
kvvvvGdkgvGKssllsqlvgeefp...................kkklpeeikgdtlavktlevdvdtel.............lelwdlggreelkkehe

FFLSERSVYIVAWNCALAEEESRV-EF--WLQSITTRAKDAPIIIVGTHLD
..| .......   ..  |  ..| |.  ||...  ..|  |.|.||..||
lllkkadaillvydltdeesleevsellawlaelrklgkkipvilvgnklD
Ras Ras family 1724-1884 7.8e-16 44.3 Pfam-A 1-143 (162) alignment 
Range on Protein: 1724-1884
Range on HMM: 1-143/162.0
KLMIVGQENVGKTTLLKTLKEKKKKATpSGPNISTDgiaidqwvfsclF-------EeldetsqngrlikkKQDITLSIWDFAGQEIYYTTHQFFLSERS
||..||...||||.||    |.| | . . . |  |            |       .              .....|.||| |||| . . .. .... .
KlvlvGdsavGKtslllrfvedkFkee.yesTigvd............fytkeievd..............gkevkleiwDTAGqeefkslrslyyrdae

VYIVAWNCALAEEESRVEFWLQSITTRAK-DAPIIIVGTHLDDVN-RTTAKMQKKRMKEKYLIRYQNIKA
. .. ..   .|  ..|. |.. |.. |. . ||..||.  |  . |.  . . ... ... ... .. |
gillvyditsresfenvkkwveeikrvaeenvpivLvGnKvDleekravsteegeelakelglkfletSA
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 847-988 4.7e-13 41.1 In-house 20-172 (404) alignment 
Range on Protein: 847-988
Range on HMM: 20-172/404.0
SLLQEYNRIGVSWD-LWRTTTQ---SKLCEHYPPTSVVPKSVSDNIVVTSAYYRSYG-FPVLAWSHPTQKSSITRATSPE---DQNNGSSNYLL-T--PN
.  .||.|.|.. .  || ..     .||| || . |||.|.||. ....| .|| | .|||.| |. ..|.|||.  |     ..  ... .|      
daeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGltksrseedEklinsirk

SPNSSSSNLANNNNSNNNNINNNNNNNNNNNNNNNNNSNNNNNNNNNNNNNNN
. ..... .  ..... | ..|... ..... ....|....  | .| .. ..
aktqletlyildarpkanavansakgagyedisryenceieflnienihelre
subfamily_MTMR1_pd Subfamily MTMR1 848-965 1e-12 40.1 In-house 12-140 (389) alignment 
Range on Protein: 848-965
Range on HMM: 12-140/389.0
LLQEYNRIGVSWD-LWRTTT---QSKLCEHYPPTSVVPKSVSDNIVVTSAYYRSYG-FPVLAWSHPTQKSSITRATSPEDQNNGS-----SNYLLTPNSP
  .|..| |.  . |||.|.   . .||. ||.. ||||.|||. .  .| .|| | .|||.| .......|.||. |    .|.      .|| .  . 
peaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqailea

NSSSSNLANNNNSN-NNNINNNNNNNNNN
|..|..|.  .. .  | ..|... .. .
naqsekllildarssvnavankakgkgye
subfamily_MTMR9_pd Subfamily MTMR9 841-923 3.8e-12 38.0 In-house 13-99 (393) alignment 
Range on Protein: 841-923
Range on HMM: 13-99/393.0
ECFPDHSLLQEYNRIGVSWDLWR---TTTQSKLCEHYPPTSVVPKSVSDNIVVTSAYYRSY-GFPVLAWSHPTQKSSITRATSPEDQ
. . . .  .|...  .. | ||   .  . |.|. ||.. .|||...|. ...|| .|.   ||||.. | ..|. . |.. |   
dgysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcg
subfamily_MTMR6_pd Subfamily MTMR6 827-922 4.1e-12 38.1 In-house 3-102 (397) alignment 
Range on Protein: 827-922
Range on HMM: 3-102/397.0
IFAYNSKESSFGNTECFPDHSLLQEYNRIGVSWDLWRTTT---QSKLCEHYPPTSVVPKSVSDNIVVTSAYYRSYG-FPVLAWSHPTQKSSITRATSPED
 | |..|.... ... .   .| .||.|.||. . | .|    . .||. || . .||||.. ...|.|. .|| | .|||.. | .....| |.. |  
afsykpkkdkeekvsGwklldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqpls
subfamily_MTMR3_pd Subfamily MTMR3 846-979 1.8e-11 36.5 In-house 27-169 (442) alignment 
Range on Protein: 846-979
Range on HMM: 27-169/442.0
HSLLQEYNRIGV----SWDLWRTTTQSKLCEHYPPTSVVPKSVSDNIVVTSAYYRSYG-FPVLAWSHPTQKSSITRATSPEDQN----NGSSNYLLTPNS
..| .|..|.|     .| .    .. |||. || . .||||..|. .  .| .||.. .|.. | | .... ..|.. ||       | . ..||.  .
eklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaedekllkaia

PNSSSSNLANNNNSNNNNINNNNNNNNNNNNNNNNNSNNNNNN
  ... .  .....   | ...... ... ... . |....  
kacaldagekakgeklsngkakkkdvsdaldaeadaseeesla
Arf ADP-ribosylation factor family 1720-1904 1.6e-09 23.6 Pfam-A 12-172 (175) alignment 
Range on Protein: 1720-1904
Range on HMM: 12-172/175.0
CYKMKLMIVGQENVGKTTLLKTLKEKKKKAtpsgpNISTDGIAIDQWVFsclfeeldetsqngrlikkkQDITLSIWDFAGQEIYYTTHQFFLSERSVYI
  .......| .| ||||.|| ||... .       . | |  ...  .                    .......||  |||      . ....  . |
kkelrilllGLDnaGKtTilkklkleelvt.....tvPTigfnveelei....................knlkftvwDvGGqeklRplWknYfektdavi

VAWNCALAEEESRVEFWLQSITT--RAKDAPIIIVGTHLDDVNRTTAKMQKKRMKEKYlIRYQNIKAIKLVSCTSGKGITSLREKLE
    .|  |  .  .  |.....  . |........   |  .  ...  .. .. .  .. ..   |  .| ..|.|...  |.| 
fvvDsadreRleeakeeLkalleeeelkevallvlaNKqDlpealseeelrellglee.lkgkrkleiqkcsavkgeglkeglewls
WD40 WD domain, G-beta repeat 2904-2937 2.1e-07 17.3 Pfam-A 4-39 (39) alignment 
Range on Protein: 2904-2937
Range on HMM: 4-39/39.0
VQMTKAHERAIHAMIQVDD--HVWTASSDGTIKVWS
..  ..|. .. ..   .|  .. ..|.||||..|.
katlrgHtspVtcvafspdgpllasgSrDgtirlWd
WD40 WD domain, G-beta repeat 2945-2977 5e-07 16.1 Pfam-A 5-39 (39) alignment 
Range on Protein: 2945-2977
Range on HMM: 5-39/39.0
TIENAHSSRIFTLELVGD--FVWSGSWDTTIKIWS
..  .|.| .  .    |  .. |||.| ||..|.
atlrgHtspVtcvafspdgpllasgSrDgtirlWd
RA Ras association (RalGDS/AF-6) domain 10-68 9.3e-06 13.6 Pfam-A 7-65 (93) alignment 
Range on Protein: 10-68
Range on HMM: 7-65/93.0
FHIPDGN--TLKKMVRVDNTTKIGEMSRLLLDKFGRsDFDPSQFQLIvPQKTATISFHVLS
.. .||.  |  | ..|..||.. |. . ||.|||  . .| ...|.  ...  .. .|||
VytedgkpgttyktilvsstttaqeVieallekfgl.edspedyaLv.eslerggeervLs