Gene DDB_G0285699 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP037_AA protein Get Run
DdisP037_AA_5-153 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Y_phosphatase2 Tyrosine phosphatase family 8-169 5e-45 145.3 Pfam-A 1-162 (165) alignment
Range on Protein: 8-169
Range on HMM: 1-162/165.0
LIPPFRFAIVEEGLLRGSYPTDRNFRFLKRLKLKTIVSLTPKPPTKSFYTFCERYNTTTKHFTVSKFKD-DVTLSAAQVAQLLEMMIEPNNLPMYIHCLD
|.||..|. ||..| |.|||  .|| |||.||||||.||.|.. ... ..|.|  .  . |. ... |. .| .   .. . |..... .| |...|| .
lvpplnFsaveselyrssyprasnfsflksLkLktiislspeeesqdelqfleeekiklyhiaiesnkeelveiksdllkkalklllnkenypvllhckr

GANVTGTIFMCLRKLQNWNLSSIFQEFTRFTRGgTIASSEAEFVETFKAEIDVCPHIPPWLWQ
|  .||.. .||||||.|.| ||..|. ||..      ...||.| |. |. |  . . . ..
GkhrtglvigclRklqkWslasilnEyrrFsgs.kkrivdeefienfdselevekknkklkvl

subfamily_OCA_pd Subfamily OCA 6-154 1.2e-29 93.6 In-house 142-282 (282) alignment
Range on Protein: 6-154
Range on HMM: 142-282/282.0
DPLIPPFRFAIVEE--------GLLRGSYPTDRNFRFL-KRLKLKTIVSLTPKP-PTKSFYTFCERYNTTTKHFTVskfkddvtlsaaqvaQLLEMMIEP
  |.|| .|..|||        |||| ..|...|..|| .||.|||...|...  ...... |... .... ...                ..|..... 
yslvpprnfslveeykdkpvisgllrlllpeeenlpfLidrlglktaliLdaeeveretiadflasseiklvslrn...............evlkdlldn

NNLPMYIHCldgANVTGTIFMCLRKLQNWNLSSIFQEFTRFTRGGTIASSEAEFVETFK
.|......|    . |.|....|||...... ||..|...||   .   ......|.|.
dnyavelsc...qaktdtvlkvLrkdkkygstsiyleyigFtledqeslksillielfd

0051082 (Phosphotyrosine protein) phosphatases II 7-143 2.6e-28 93.9 In-house 1-138 (151) alignment
Range on Protein: 7-143
Range on HMM: 1-138/151.0
PLIPPFRFAIVEEGLLRGSYPTDRNFRFLKRLKLKTIVSLTPKPPTKSFYTFCERYNTTTKHFTVSKFKDD-VTLSAAQVAQLLEMMIEPNNLPMYIHCL
|| ... |  |..||.|...|.......||.|..||||.|....... .. ...... . .|. .  ..|  . || ..|...||......| |...|| 
plsdyinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCs

DGANVTGTIFMCLRKLQNWNLSSIFQEFTRFTRGGTIA
 | . |||. .....|....| ....|. ..  | .. 
aGkgRTGtlvalylmllgvsleealeeyrlkrpgvvqp

0051429 (Phosphotyrosine protein) phosphatases II 14-139 1e-17 60.2 In-house 16-192 (272) alignment
Range on Protein: 14-139
Range on HMM: 16-192/272.0
FAIVEEG-LLRGSYP---TDRNFRFLKRLKLKTIVSLTPKPPTKSFYTFCERYNTTTKHFTVSKFKDDVTL-----------------------------
.  | .| |.|...|   |...|..||.|..||||.|..    ... ....  . .  |. .  . .   |                             
grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltllls

----------------------SAaqVAQLLEMMIEpnNLPMYIHCLDGANVTGTIFMCLRKLQNWNLSSIFQEFTRFTRG
                      .|  . .|||.. .  . |...||  | . |||. ..|. |....|. |.... ... .
agearevmhlhytdwpdhgvpqea..llellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

0048179 (Phosphotyrosine protein) phosphatases II 14-144 6.5e-16 53.8 In-house 4-131 (144) alignment
Range on Protein: 14-144
Range on HMM: 4-131/144.0
FAIVEEGLLRGSYPTDRNFRFLKRLKLKTIVSLTPKpptkSFYTFCERYNTTTKHFTVSKFkddVTLSA-AQVAQLLEMM--IEPNNLPMYIHCLDGANV
.. . .|| .||.|| ... .||.|...|...||..      ..|.||....  |. .  .    . .  ... ..||..  . ... |...||  | . 
pseilpglylgslptaldlellkklgittvinltee....yepefleregiqylhlpwpDh...gvpdllellleflefieealeeggpvlVHCsaGvgR

TGTIFMC-LRKLQNWNLSSIFQEFTRFTRGGTIAS
|||. .. | |.....| ...... .   |. .  
tgtlvaaylmkklglsleealalvrsrrpgavpnp

0041856 (Phosphotyrosine protein) phosphatases II 14-153 8.3e-16 53.5 In-house 19-166 (182) alignment
Range on Protein: 14-153
Range on HMM: 19-166/182.0
FAIVEEGLLRGSYPT--------------DRNFRFLKRLKLKTIVSLTpkpptkSFYTFCERYNTTTKHFTVSKFKDDVTLSAAQVAQLLEMMIEpNNLP
.  . ..|..||.|.               ...|.||.|. .|||.||      ... . |... .  ..    . |. . .  .. ...|...| .. |
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpdldelldfieevle.eggp

MYIHCLDGANVTGTIFMC-LRKLQNWNLSSIFQEFTRFTRGGTIASSEAEFVETF
 ..||  | . |||. .. | | ....| ...... .   |. |  .   |.  .
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqla

0044763 (Phosphotyrosine protein) phosphatases II 9-136 9.7e-16 53.4 In-house 18-150 (178) alignment
Range on Protein: 9-136
Range on HMM: 18-150/178.0
IPPFRFAIVEEGLLRGSYPTDRNFRFLKRLKLKTIVSLTPKPP---TKSFYTFCERYNTTTKHFTVSKFKDDV-TLSAAQVAQLLEMMIEPNNLPMYIHC
.... .  . .||..||.|. .....||.|....||.||.  .    |..  ..|... . .|. .. ...   .    .. ...|  ..... | ..||
sdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHC

LDGANVTGTIFMC-LRKLQNWNLSSIFQEFTRF
  | . .||. .. | | ....| ...... . 
saGvgRsgtlvaaylmkklglsleeaielvrer

0042113 (Phosphotyrosine protein) phosphatases II 6-140 1.3e-15 52.9 In-house 34-225 (245) alignment
Range on Protein: 6-140
Range on HMM: 34-225/245.0
DPLIPPFRFAIV-----EEGLLRGSYPTDRNFR----FLKRLKLKTIVSLTPKPPTKSF----------------------------------------Y
|.  ..  .  |      ........|.. ..     .|..|...|||.||.  . .                                          .
dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlg

TFCERYNTTTKHFTVSkfKDDVTLSAAQVAQLLEMMIE----PNNLPMYIHCLDGANVTGTIFMCLR------KLQNWNLSSIFQEFTRFTRGG
....| ...  .. .    ..|. . ... ..||.. .    ..| |...|| .| . |||. ....      |.....| ....|. .. .| 
ddesrevihyhylpwp..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpga

0048076 (Phosphotyrosine protein) phosphatases II 14-145 1.4e-15 52.7 In-house 4-130 (145) alignment
Range on Protein: 14-145
Range on HMM: 4-130/145.0
FAIVEEGLLRGSYPTDRNFRFLKRLKLKTIVSLtpkpptksfYTFCERYNTTTKHFTVSKFKDDVTLSA-AQVAQLLEMM--IEPNNLPMYIHCLDGANV
.. . .|| .||.|| .....||.|...|...|          . .| .  .  ..    . |  . .  ... ..||..  . ... |...||  | . 
pseilpglylgslptaldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgR

TGTIFMC-LRKLQNWNLSSIFQEFTRFTRGGTIASS
|||. .. | .|....| ...... .  .|. .  .
tgtlvaaylmlllgvsleealelvrsqrpgavpnpg

0036282 (Phosphotyrosine protein) phosphatases II 11-136 2.6e-13 45.5 In-house 9-145 (174) alignment
Range on Protein: 11-136
Range on HMM: 9-145/174.0
PFRFAIVEEGLLRGSYPTDrNFRFLKRLKLKTIVSLTPKPPTK------SFYTFCERYNTTTKHFTVSKFKDDVTLSAAQVAQLLEMMIE----PNNLPM
|  . .. ..|..|..|.. ....||.|...|.|.|..  . .       .... | .  .  ..    . |. . . ... .... . |    ... |.
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

YIHCLDGANVTGTIFMCLRKLQNW--NLSSIFQEFTRF
..||  | . |||. .... |...  .|  ... . . 
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrel

0040439 (Phosphotyrosine protein) phosphatases II 7-145 2.6e-12 42.4 In-house 18-233 (249) alignment
Range on Protein: 7-145
Range on HMM: 18-233/249.0
PLIPPFRFAIVEEGLLRGSYP----------------------------TDRNFRFLKRLKLKTIVSLTPKPPTKSFYTF--------------------
| |.|. .  |  . |.| ..                            .. ..|.|..|. ..||.||.  . .    .                    
pdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtlls

-----------------CERYNTTTKHFTVSKFKDD-VTLSAAQVAQLLEMMIE-----PNNLPMYIHCLDGANVTGTIFMCLR------KLQNWNLSSI
                  .    | .|. . .. |. |  | ... ...|.. .     |.. |...|| .| . |||. ...       | ....| ..
vevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleea

FQEFTRFTRGGTIASS
.... .  .|.    .
vkllrsqRpgavqnpe

0039614 (Phosphotyrosine protein) phosphatases II 9-136 3.7e-12 41.8 In-house 65-267 (297) alignment
Range on Protein: 9-136
Range on HMM: 65-267/297.0
IPPFRFAIV--------------------------EEGLLRGSYPTDRN----FRFLKRLKLKTIVSLTPKPPTKS----------------------FY
|.|. .  |                              .. ..|.. .    .|...... ..||.||.  . .                       ..
ilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkve

TfCERYN------------TTTKHFTVSKFKDDVTL-SAAQVAQLLEMMIE-----PNNLPMYIHCLDGANVTGTIFMCLR------KLQNWNLSSIFQE
. .. |.             | .|| . .. |. .  |.... ..||.. |     |.. |...|| .| . |||. ....      | ..... ....|
h.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavke

FTRF
. . 
lreq

0043336 (Phosphotyrosine protein) phosphatases II 11-141 1.1e-11 40.2 In-house 56-260 (278) alignment
Range on Protein: 11-141
Range on HMM: 56-260/278.0
PFRFAIV------------------------EEGLLRGSYPTDRN----FRFLKRLKLKTIVSLTPKPPTKS----------------------------
|. .  |                         .. .. ..|.. .    .|... |. .|||.||.    ..                            
pydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehld

---FYTF-----CERYNTTTKHFTVSKFKDDVTL-SAAQVAQLLEMMIE---PNNLPMYIHCLDGANVTGTIFMCLR------KLQNWNLSSIFQEFTRF
    .|.      . .  |  |.   .. |. .  | ... ..|....|   ..| |...|| .| . |||. ....      | ....| ....|. ..
dytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreq

TRGGT
  |  
Rpgav

0037934 (Phosphotyrosine protein) phosphatases II 16-135 2.5e-11 39.1 In-house 41-218 (243) alignment
Range on Protein: 16-135
Range on HMM: 41-218/243.0
IVEEGLLRGSYPTDR--------NFRFLKRLKLKTIVSLTPKP----------------------PTKSFY--------------TFCERYNTTTKHFTV
 | ..| ....|..         ..|.|..|. ..||.||.                         ..|..              . .. .  .  |.  
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

SKFKDDVTLS-AAQVAQLLEMMIE-----------PNNLPMYIHCLDGANVTGTIFMCLRKLQ--NWNLSSIFQEFTR
  . |  . .  ... ..|....|           ... |...||  | . |||. ...  |.  ...| ...... .
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllre

0040438 (Phosphotyrosine protein) phosphatases II 32-143 2e-10 35.9 In-house 103-261 (317) alignment
Range on Protein: 32-143
Range on HMM: 103-261/317.0
FRFLKRLKLKTIVSLTPKPPTK---------------------SFYTFCERYNTTTKHFTVSK-----------------FKDDVTLSAAQVAQLLEMMI
.|.........||.||.  . .                      .. . |  . |  ...|..                   ..|  |  .. ..||.. 
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

EP---NNLPMYIHCLDGANVTGTIFMCLR------KLQNWNLSSIFQEFTRFTRGGTIA
|    .. |. .|| .| . |||. ....      | ..... ....|. .. .|.   
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqt

0045450 (Phosphotyrosine protein) phosphatases II 20-135 2.3e-10 36.2 In-house 97-281 (307) alignment
Range on Protein: 20-135
Range on HMM: 97-281/307.0
GLLRGSYPTDRNF---------------RFLKRLKLKTIVSLTPKPPTKS----------------------FYTFCERYNTTTKHFTVSKF--------
.||...|  .|.|               |.|.... ..||.||.  . ..                      .. . .  . |  ...|.          
lllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrt

----------KDDVTLSAAQVAQLLEMMIE-----PNNLPMYIHCLDGANVTGTIFMCLRKLQN---------WNLSSIFQEFTR
           ..|  | ... ...|.. .     |.. |...|| .| . |||. ...  |..         ..| ...... .
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllre

0043147 (Phosphotyrosine protein) phosphatases II 23-134 2.7e-10 35.7 In-house 28-137 (172) alignment
Range on Protein: 23-134
Range on HMM: 28-137/172.0
RGSYPTDRNFRFLKRLKLKTIVSLTPKpptksfYTFCERYNTTTKHFTVSKFKDDVTLSAAQVAQLLEMMIE----PNNLPMYIHCLDGANVTGTIFMCL
 ...... ..|.||.|. ..||.||.       .. .| .  .  ..    . |  . ..... ..|| . |     .. |...||  | . |||. ...
plrntladfwrmlkelgithivnltel......lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaay

RKLQNWNLSSIFQEFT
  |....|  ..... 
lmllglsleeavalvr

0045098 (Phosphotyrosine protein) phosphatases II 8-135 5.8e-10 34.5 In-house 16-248 (278) alignment
Range on Protein: 8-135
Range on HMM: 16-248/278.0
LIPPFRFAIVEEGLLRGSYP-----------------------------------------TDRNFRFLKRLKLKTIVSLTPKPPTK-------------
|.... .  ....|..|...                                         .. ..|.|. |. ..||.||.  . .             
llllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

----------------------------SFYTFCERYNTTTKHFTVSKFKDDVTLSAA---QVAQLLEMMIE----------------PNNLPMYIHCLD
                             .. . . .. . .|.    . |  . |     .. .|||.. |                ... |...||  
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GANVTGTIFMCLRKLQ----NWNLSSIFQEFTR
| . |||. ..   |.    ...| ....|. .
GvgRtGtlvaaylmlelleggvdlleavkelrs

0049260 (Phosphotyrosine protein) phosphatases II 21-135 1.3e-09 33.4 In-house 15-127 (152) alignment
Range on Protein: 21-135
Range on HMM: 15-127/152.0
LLRGSYPTDRNFRFLKRLKLKTIVSLTPKPPtkSFYTFCERYNtttkHFTVSKFKDDVTLSAAQVAQLLEMMI----EPNNLPMYIHCLDGANVTGTIFM
.  |..... ..|.||.|. .|||.||   .    . .||.|     ..    . |. . . .|. . |  .|    . .. | ..||  | . |||. .
qgpgpntladfwrmlkelgittivmltelle..lgklkceqyi....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

CLRKLQNWNLSSIFQEFTR
..  |....|  ... . .
aylmllgvsleeavalvre

0049772 (Phosphotyrosine protein) phosphatases II 17-136 1.8e-09 33.3 In-house 155-253 (314) alignment
Range on Protein: 17-136
Range on HMM: 155-253/314.0
VeegllrgSYPTDRNFRFLKrlklktivsltpkpptkSFYTFCERYNTT---TKHFtvsKFKDDVTLSAAQVAQLLEMMIE-PNNLPMYIHCLDGANVTG
        ..|| ... .||                 . ..  |..  .    ...    . |. . . ... ..||.. | ... | ..|| .| . ||
g.......neptaadlellk.................eelydpelferlgikylri...pvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtg

--TIFMCLRKLQNWNLSSIFQEFTRF
   . ..| ||....|  ..... . 
tfvvaaylmkllgvsleealedvrlk

0046846 (Phosphotyrosine protein) phosphatases II 11-134 5.8e-09 31.5 In-house 9-148 (176) alignment
Range on Protein: 11-134
Range on HMM: 9-148/176.0
PFRFAIVEEGLLRGSYP----------TDRNFRFLKRLKLKTIVSLTPKPPTKSF--YTFCERYNTTTKHFTVSKFKDDVTLSAAQVAQLLEMMIEP--N
.. .  . ..|. ||.|          .  ....||.|. ...|.||    ....  ....... .   .. .  . |  . . ... .|||.. |   .
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealke

NLPMYIHCLDGANVTGTIFMCLRKLQ--NWNLSSIFQEFT
. | ..||  | . |||. ...      ....  ..... 
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvr

0036941 (Phosphotyrosine protein) phosphatases II 33-135 1.7e-06 23.0 In-house 96-254 (297) alignment
Range on Protein: 33-135
Range on HMM: 96-254/297.0
RFLKRLKLKTIVSLTPKPP------------TKSFYTFCERYNTTTKHFTV-----------------------------SKF-KDDVTLSAAQVAQLLE
| .  .. ..||.||.  .            ..  .  ....  |.....|                              .   ..|  |.|.. ...|
rmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

MMIE-----PNNLPMYIHCLDGANVTGTIFMCLR---------KLQNWNLSSIFQEFTR
.. .     |.. |...|| .| . .||. ..           | ..... ...... .
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklRe

PTEN_1 10-151 8.1e-06 20.8 In-house 39-186 (196) alignment
Range on Protein: 10-151
Range on HMM: 39-186/196.0
PPFRfaIVEEGLLRGSYPTD-RNFRFLKRLKLKTIVSLTPKPPTkS----FYTFCERYNTTTKHFTVSKFK-DDVTLSAAQVAQLLEMMIE-PNNLPMYI
|...   ..|||.|||..   .... ||  .. ..|.|...... |      ..... . . .|| .  .   .     . .... | ... ||.   ..
pllq..eideglyrgslkdvaadldnlkedgitlvvnlseeeel.sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlV

HCLDGANVTGTIFMC-LRKLQNWNLSSIFQEFTRFT-RGGTIASSEAEFVE
||  | . .||. .. | ......    .. . .   .|.   .|  ...|
HCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlle