Gene DDB_G0285699 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP037_AA protein Get Run
DdisP037_AA_5-153 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Y_phosphatase2 Tyrosine phosphatase family 8-169 5e-45 145.3 Pfam-A 1-162 (165) alignment 
Range on Protein: 8-169
Range on HMM: 1-162/165.0
LIPPFRFAIVEEGLLRGSYPTDRNFRFLKRLKLKTIVSLTPKPPTKSFYTFCERYNTTTKHFTVSKFKD-DVTLSAAQVAQLLEMMIEPNNLPMYIHCLD
|.||..|. ||..| |.|||  .|| |||.||||||.||.|.. ... ..|.|  .  . |. ... |. .| .   .. . |..... .| |...|| .
lvpplnFsaveselyrssyprasnfsflksLkLktiislspeeesqdelqfleeekiklyhiaiesnkeelveiksdllkkalklllnkenypvllhckr

GANVTGTIFMCLRKLQNWNLSSIFQEFTRFTRGgTIASSEAEFVETFKAEIDVCPHIPPWLWQ
|  .||.. .||||||.|.| ||..|. ||..      ...||.| |. |. |  . . . ..
GkhrtglvigclRklqkWslasilnEyrrFsgs.kkrivdeefienfdselevekknkklkvl
subfamily_OCA_pd Subfamily OCA 6-154 1.2e-29 93.6 In-house 142-282 (282) alignment 
Range on Protein: 6-154
Range on HMM: 142-282/282.0
DPLIPPFRFAIVEE--------GLLRGSYPTDRNFRFL-KRLKLKTIVSLTPKP-PTKSFYTFCERYNTTTKHFTVskfkddvtlsaaqvaQLLEMMIEP
  |.|| .|..|||        |||| ..|...|..|| .||.|||...|...  ...... |... .... ...                ..|..... 
yslvpprnfslveeykdkpvisgllrlllpeeenlpfLidrlglktaliLdaeeveretiadflasseiklvslrn...............evlkdlldn

NNLPMYIHCldgANVTGTIFMCLRKLQNWNLSSIFQEFTRFTRGGTIASSEAEFVETFK
.|......|    . |.|....|||...... ||..|...||   .   ......|.|.
dnyavelsc...qaktdtvlkvLrkdkkygstsiyleyigFtledqeslksillielfd
0051082 (Phosphotyrosine protein) phosphatases II 7-143 2.6e-28 93.9 In-house 1-138 (151) alignment 
Range on Protein: 7-143
Range on HMM: 1-138/151.0
PLIPPFRFAIVEEGLLRGSYPTDRNFRFLKRLKLKTIVSLTPKPPTKSFYTFCERYNTTTKHFTVSKFKDD-VTLSAAQVAQLLEMMIEPNNLPMYIHCL
|| ... |  |..||.|...|.......||.|..||||.|....... .. ...... . .|. .  ..|  . || ..|...||......| |...|| 
plsdyinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCs

DGANVTGTIFMCLRKLQNWNLSSIFQEFTRFTRGGTIA
 | . |||. .....|....| ....|. ..  | .. 
aGkgRTGtlvalylmllgvsleealeeyrlkrpgvvqp
0051429 (Phosphotyrosine protein) phosphatases II 14-139 1e-17 60.2 In-house 16-192 (272) alignment 
Range on Protein: 14-139
Range on HMM: 16-192/272.0
FAIVEEG-LLRGSYP---TDRNFRFLKRLKLKTIVSLTPKPPTKSFYTFCERYNTTTKHFTVSKFKDDVTL-----------------------------
.  | .| |.|...|   |...|..||.|..||||.|..    ... ....  . .  |. .  . .   |                             
grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltllls

----------------------SAaqVAQLLEMMIEpnNLPMYIHCLDGANVTGTIFMCLRKLQNWNLSSIFQEFTRFTRG
                      .|  . .|||.. .  . |...||  | . |||. ..|. |....|. |.... ... .
agearevmhlhytdwpdhgvpqea..llellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly
0048179 (Phosphotyrosine protein) phosphatases II 14-144 6.5e-16 53.8 In-house 4-131 (144) alignment 
Range on Protein: 14-144
Range on HMM: 4-131/144.0
FAIVEEGLLRGSYPTDRNFRFLKRLKLKTIVSLTPKpptkSFYTFCERYNTTTKHFTVSKFkddVTLSA-AQVAQLLEMM--IEPNNLPMYIHCLDGANV
.. . .|| .||.|| ... .||.|...|...||..      ..|.||....  |. .  .    . .  ... ..||..  . ... |...||  | . 
pseilpglylgslptaldlellkklgittvinltee....yepefleregiqylhlpwpDh...gvpdllellleflefieealeeggpvlVHCsaGvgR

TGTIFMC-LRKLQNWNLSSIFQEFTRFTRGGTIAS
|||. .. | |.....| ...... .   |. .  
tgtlvaaylmkklglsleealalvrsrrpgavpnp
0041856 (Phosphotyrosine protein) phosphatases II 14-153 8.3e-16 53.5 In-house 19-166 (182) alignment 
Range on Protein: 14-153
Range on HMM: 19-166/182.0
FAIVEEGLLRGSYPT--------------DRNFRFLKRLKLKTIVSLTpkpptkSFYTFCERYNTTTKHFTVSKFKDDVTLSAAQVAQLLEMMIEpNNLP
.  . ..|..||.|.               ...|.||.|. .|||.||      ... . |... .  ..    . |. . .  .. ...|...| .. |
ldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpdldelldfieevle.eggp

MYIHCLDGANVTGTIFMC-LRKLQNWNLSSIFQEFTRFTRGGTIASSEAEFVETF
 ..||  | . |||. .. | | ....| ...... .   |. |  .   |.  .
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqla
0044763 (Phosphotyrosine protein) phosphatases II 9-136 9.7e-16 53.4 In-house 18-150 (178) alignment 
Range on Protein: 9-136
Range on HMM: 18-150/178.0
IPPFRFAIVEEGLLRGSYPTDRNFRFLKRLKLKTIVSLTPKPP---TKSFYTFCERYNTTTKHFTVSKFKDDV-TLSAAQVAQLLEMMIEPNNLPMYIHC
.... .  . .||..||.|. .....||.|....||.||.  .    |..  ..|... . .|. .. ...   .    .. ...|  ..... | ..||
sdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHC

LDGANVTGTIFMC-LRKLQNWNLSSIFQEFTRF
  | . .||. .. | | ....| ...... . 
saGvgRsgtlvaaylmkklglsleeaielvrer
0042113 (Phosphotyrosine protein) phosphatases II 6-140 1.3e-15 52.9 In-house 34-225 (245) alignment 
Range on Protein: 6-140
Range on HMM: 34-225/245.0
DPLIPPFRFAIV-----EEGLLRGSYPTDRNFR----FLKRLKLKTIVSLTPKPPTKSF----------------------------------------Y
|.  ..  .  |      ........|.. ..     .|..|...|||.||.  . .                                          .
dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlg

TFCERYNTTTKHFTVSkfKDDVTLSAAQVAQLLEMMIE----PNNLPMYIHCLDGANVTGTIFMCLR------KLQNWNLSSIFQEFTRFTRGG
....| ...  .. .    ..|. . ... ..||.. .    ..| |...|| .| . |||. ....      |.....| ....|. .. .| 
ddesrevihyhylpwp..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpga
0048076 (Phosphotyrosine protein) phosphatases II 14-145 1.4e-15 52.7 In-house 4-130 (145) alignment 
Range on Protein: 14-145
Range on HMM: 4-130/145.0
FAIVEEGLLRGSYPTDRNFRFLKRLKLKTIVSLtpkpptksfYTFCERYNTTTKHFTVSKFKDDVTLSA-AQVAQLLEMM--IEPNNLPMYIHCLDGANV
.. . .|| .||.|| .....||.|...|...|          . .| .  .  ..    . |  . .  ... ..||..  . ... |...||  | . 
pseilpglylgslptaldlellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgR

TGTIFMC-LRKLQNWNLSSIFQEFTRFTRGGTIASS
|||. .. | .|....| ...... .  .|. .  .
tgtlvaaylmlllgvsleealelvrsqrpgavpnpg
0036282 (Phosphotyrosine protein) phosphatases II 11-136 2.6e-13 45.5 In-house 9-145 (174) alignment 
Range on Protein: 11-136
Range on HMM: 9-145/174.0
PFRFAIVEEGLLRGSYPTDrNFRFLKRLKLKTIVSLTPKPPTK------SFYTFCERYNTTTKHFTVSKFKDDVTLSAAQVAQLLEMMIE----PNNLPM
|  . .. ..|..|..|.. ....||.|...|.|.|..  . .       .... | .  .  ..    . |. . . ... .... . |    ... |.
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

YIHCLDGANVTGTIFMCLRKLQNW--NLSSIFQEFTRF
..||  | . |||. .... |...  .|  ... . . 
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrel
0040439 (Phosphotyrosine protein) phosphatases II 7-145 2.6e-12 42.4 In-house 18-233 (249) alignment 
Range on Protein: 7-145
Range on HMM: 18-233/249.0
PLIPPFRFAIVEEGLLRGSYP----------------------------TDRNFRFLKRLKLKTIVSLTPKPPTKSFYTF--------------------
| |.|. .  |  . |.| ..                            .. ..|.|..|. ..||.||.  . .    .                    
pdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtlls

-----------------CERYNTTTKHFTVSKFKDD-VTLSAAQVAQLLEMMIE-----PNNLPMYIHCLDGANVTGTIFMCLR------KLQNWNLSSI
                  .    | .|. . .. |. |  | ... ...|.. .     |.. |...|| .| . |||. ...       | ....| ..
vevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleea

FQEFTRFTRGGTIASS
.... .  .|.    .
vkllrsqRpgavqnpe
0039614 (Phosphotyrosine protein) phosphatases II 9-136 3.7e-12 41.8 In-house 65-267 (297) alignment 
Range on Protein: 9-136
Range on HMM: 65-267/297.0
IPPFRFAIV--------------------------EEGLLRGSYPTDRN----FRFLKRLKLKTIVSLTPKPPTKS----------------------FY
|.|. .  |                              .. ..|.. .    .|...... ..||.||.  . .                       ..
ilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkve

TfCERYN------------TTTKHFTVSKFKDDVTL-SAAQVAQLLEMMIE-----PNNLPMYIHCLDGANVTGTIFMCLR------KLQNWNLSSIFQE
. .. |.             | .|| . .. |. .  |.... ..||.. |     |.. |...|| .| . |||. ....      | ..... ....|
h.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavke

FTRF
. . 
lreq
0043336 (Phosphotyrosine protein) phosphatases II 11-141 1.1e-11 40.2 In-house 56-260 (278) alignment 
Range on Protein: 11-141
Range on HMM: 56-260/278.0
PFRFAIV------------------------EEGLLRGSYPTDRN----FRFLKRLKLKTIVSLTPKPPTKS----------------------------
|. .  |                         .. .. ..|.. .    .|... |. .|||.||.    ..                            
pydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehld

---FYTF-----CERYNTTTKHFTVSKFKDDVTL-SAAQVAQLLEMMIE---PNNLPMYIHCLDGANVTGTIFMCLR------KLQNWNLSSIFQEFTRF
    .|.      . .  |  |.   .. |. .  | ... ..|....|   ..| |...|| .| . |||. ....      | ....| ....|. ..
dytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreq

TRGGT
  |  
Rpgav
0037934 (Phosphotyrosine protein) phosphatases II 16-135 2.5e-11 39.1 In-house 41-218 (243) alignment 
Range on Protein: 16-135
Range on HMM: 41-218/243.0
IVEEGLLRGSYPTDR--------NFRFLKRLKLKTIVSLTPKP----------------------PTKSFY--------------TFCERYNTTTKHFTV
 | ..| ....|..         ..|.|..|. ..||.||.                         ..|..              . .. .  .  |.  
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

SKFKDDVTLS-AAQVAQLLEMMIE-----------PNNLPMYIHCLDGANVTGTIFMCLRKLQ--NWNLSSIFQEFTR
  . |  . .  ... ..|....|           ... |...||  | . |||. ...  |.  ...| ...... .
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllre
0040438 (Phosphotyrosine protein) phosphatases II 32-143 2e-10 35.9 In-house 103-261 (317) alignment 
Range on Protein: 32-143
Range on HMM: 103-261/317.0
FRFLKRLKLKTIVSLTPKPPTK---------------------SFYTFCERYNTTTKHFTVSK-----------------FKDDVTLSAAQVAQLLEMMI
.|.........||.||.  . .                      .. . |  . |  ...|..                   ..|  |  .. ..||.. 
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

EP---NNLPMYIHCLDGANVTGTIFMCLR------KLQNWNLSSIFQEFTRFTRGGTIA
|    .. |. .|| .| . |||. ....      | ..... ....|. .. .|.   
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqt
0045450 (Phosphotyrosine protein) phosphatases II 20-135 2.3e-10 36.2 In-house 97-281 (307) alignment 
Range on Protein: 20-135
Range on HMM: 97-281/307.0
GLLRGSYPTDRNF---------------RFLKRLKLKTIVSLTPKPPTKS----------------------FYTFCERYNTTTKHFTVSKF--------
.||...|  .|.|               |.|.... ..||.||.  . ..                      .. . .  . |  ...|.          
lllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrt

----------KDDVTLSAAQVAQLLEMMIE-----PNNLPMYIHCLDGANVTGTIFMCLRKLQN---------WNLSSIFQEFTR
           ..|  | ... ...|.. .     |.. |...|| .| . |||. ...  |..         ..| ...... .
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllre
0043147 (Phosphotyrosine protein) phosphatases II 23-134 2.7e-10 35.7 In-house 28-137 (172) alignment 
Range on Protein: 23-134
Range on HMM: 28-137/172.0
RGSYPTDRNFRFLKRLKLKTIVSLTPKpptksfYTFCERYNTTTKHFTVSKFKDDVTLSAAQVAQLLEMMIE----PNNLPMYIHCLDGANVTGTIFMCL
 ...... ..|.||.|. ..||.||.       .. .| .  .  ..    . |  . ..... ..|| . |     .. |...||  | . |||. ...
plrntladfwrmlkelgithivnltel......lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaay

RKLQNWNLSSIFQEFT
  |....|  ..... 
lmllglsleeavalvr
0045098 (Phosphotyrosine protein) phosphatases II 8-135 5.8e-10 34.5 In-house 16-248 (278) alignment 
Range on Protein: 8-135
Range on HMM: 16-248/278.0
LIPPFRFAIVEEGLLRGSYP-----------------------------------------TDRNFRFLKRLKLKTIVSLTPKPPTK-------------
|.... .  ....|..|...                                         .. ..|.|. |. ..||.||.  . .             
llllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggs

----------------------------SFYTFCERYNTTTKHFTVSKFKDDVTLSAA---QVAQLLEMMIE----------------PNNLPMYIHCLD
                             .. . . .. . .|.    . |  . |     .. .|||.. |                ... |...||  
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GANVTGTIFMCLRKLQ----NWNLSSIFQEFTR
| . |||. ..   |.    ...| ....|. .
GvgRtGtlvaaylmlelleggvdlleavkelrs
0049260 (Phosphotyrosine protein) phosphatases II 21-135 1.3e-09 33.4 In-house 15-127 (152) alignment 
Range on Protein: 21-135
Range on HMM: 15-127/152.0
LLRGSYPTDRNFRFLKRLKLKTIVSLTPKPPtkSFYTFCERYNtttkHFTVSKFKDDVTLSAAQVAQLLEMMI----EPNNLPMYIHCLDGANVTGTIFM
.  |..... ..|.||.|. .|||.||   .    . .||.|     ..    . |. . . .|. . |  .|    . .. | ..||  | . |||. .
qgpgpntladfwrmlkelgittivmltelle..lgklkceqyi....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

CLRKLQNWNLSSIFQEFTR
..  |....|  ... . .
aylmllgvsleeavalvre
0049772 (Phosphotyrosine protein) phosphatases II 17-136 1.8e-09 33.3 In-house 155-253 (314) alignment 
Range on Protein: 17-136
Range on HMM: 155-253/314.0
VeegllrgSYPTDRNFRFLKrlklktivsltpkpptkSFYTFCERYNTT---TKHFtvsKFKDDVTLSAAQVAQLLEMMIE-PNNLPMYIHCLDGANVTG
        ..|| ... .||                 . ..  |..  .    ...    . |. . . ... ..||.. | ... | ..|| .| . ||
g.......neptaadlellk.................eelydpelferlgikylri...pvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtg

--TIFMCLRKLQNWNLSSIFQEFTRF
   . ..| ||....|  ..... . 
tfvvaaylmkllgvsleealedvrlk
0046846 (Phosphotyrosine protein) phosphatases II 11-134 5.8e-09 31.5 In-house 9-148 (176) alignment 
Range on Protein: 11-134
Range on HMM: 9-148/176.0
PFRFAIVEEGLLRGSYP----------TDRNFRFLKRLKLKTIVSLTPKPPTKSF--YTFCERYNTTTKHFTVSKFKDDVTLSAAQVAQLLEMMIEP--N
.. .  . ..|. ||.|          .  ....||.|. ...|.||    ....  ....... .   .. .  . |  . . ... .|||.. |   .
dldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealke

NLPMYIHCLDGANVTGTIFMCLRKLQ--NWNLSSIFQEFT
. | ..||  | . |||. ...      ....  ..... 
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvr
0036941 (Phosphotyrosine protein) phosphatases II 33-135 1.7e-06 23.0 In-house 96-254 (297) alignment 
Range on Protein: 33-135
Range on HMM: 96-254/297.0
RFLKRLKLKTIVSLTPKPP------------TKSFYTFCERYNTTTKHFTV-----------------------------SKF-KDDVTLSAAQVAQLLE
| .  .. ..||.||.  .            ..  .  ....  |.....|                              .   ..|  |.|.. ...|
rmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfie

MMIE-----PNNLPMYIHCLDGANVTGTIFMCLR---------KLQNWNLSSIFQEFTR
.. .     |.. |...|| .| . .||. ..           | ..... ...... .
lvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklRe
PTEN_1 10-151 8.1e-06 20.8 In-house 39-186 (196) alignment 
Range on Protein: 10-151
Range on HMM: 39-186/196.0
PPFRfaIVEEGLLRGSYPTD-RNFRFLKRLKLKTIVSLTPKPPTkS----FYTFCERYNTTTKHFTVSKFK-DDVTLSAAQVAQLLEMMIE-PNNLPMYI
|...   ..|||.|||..   .... ||  .. ..|.|...... |      ..... . . .|| .  .   .     . .... | ... ||.   ..
pllq..eideglyrgslkdvaadldnlkedgitlvvnlseeeel.sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlV

HCLDGANVTGTIFMC-LRKLQNWNLSSIFQEFTRFT-RGGTIASSEAEFVE
||  | . .||. .. | ......    .. . .   .|.   .|  ...|
HCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlle