Gene DDB_G0285909 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family OCA
Subfamily OCA
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP038_AA protein Get Run
DdisP038_AA_9-175 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Y_phosphatase2 Tyrosine phosphatase family 20-173 4.8e-64 207.1 Pfam-A 2-155 (165) alignment 
Range on Protein: 20-173
Range on HMM: 2-155/165.0
IPPLNFSMVSRGVYRSGYPNKKNHPFLKKLGLKSILYLCPEEYSESNTNFIRKHGIKLLHYRIVGNKEPFVDIPDEYIRDALVDLLDVRNHPILIHCNKG
.||||||.| ...|||.||...| .|||.| ||.|..|.|||.|.....|. .. |||.|. | .|||..| |... .. ||  ||...|.|.|.||..|
vpplnFsaveselyrssyprasnfsflksLkLktiislspeeesqdelqfleeekiklyhiaiesnkeelveiksdllkkalklllnkenypvllhckrG

KHRTGCLVGCLRKLQKWSYTYIFDEYRRFAGSKVRVLDQQFIELFNLEVPYNKR
|||||...|||||||||| . |..|||||.||| |..|..||| |. |.  .|.
khrtglvigclRklqkWslasilnEyrrFsgskkrivdeefienfdselevekk
0051082 (Phosphotyrosine protein) phosphatases II 20-165 4.2e-41 135.3 In-house 3-148 (151) alignment 
Range on Protein: 20-165
Range on HMM: 3-148/151.0
IPPLNFSMVSRGVYRSGYPNKKNHPFLKKLGLKSILYLCPEEYSESNTNFIRKHGIKLLHYRIVGNKEPFVDIPDEYIRDALVDLLDVRNHPILIHCNKG
 ...|||.|  |.||||.|   . ..||.||.|.|..|..||. . .... ...||..||. |.....| ...  . ....|  ||| .|.|.|.||. |
sdyinfsyvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaG

KHRTGCLVGCLRKLQKWSYTYIFDEYRRFAGSKVRVLDQQFIELFN
|.|||.||.....|...|.  ...|||.. . .|.  .|....|| 
kgRTGtlvalylmllgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_OCA_pd Subfamily OCA 13-165 1.6e-37 119.4 In-house 138-282 (282) alignment 
Range on Protein: 13-165
Range on HMM: 138-282/282.0
TKEDPLFIPPLNFSMVSR--------GVYRSGYPNKKNHPFL-KKLGLKSILYLCPEEYSESNT-NFIRKHGIKLLHYRIvgnkepfvdipdeyirDALV
....  ..||.|||.|..        |..|...|...|.||| ..||||..|.|..||...... .|.... |||...|                 ..| 
fprlyslvpprnfslveeykdkpvisgllrlllpeeenlpfLidrlglktaliLdaeeveretiadflasseiklvslrn................evlk

DLLDVRNHPILIHCnkgKHRTGCLVGCLRKLQKWSYTYIFDEYRRFAG-SKVRVLDQQFIELFN
||||..|......|   ...|......|||..|...| |..||..|.. .. .. ....||||.
dlldndnyavelsc...qaktdtvlkvLrkdkkygstsiyleyigFtledqeslksillielfd
0044763 (Phosphotyrosine protein) phosphatases II 10-173 1.5e-31 104.8 In-house 8-175 (178) alignment 
Range on Protein: 10-173
Range on HMM: 8-175/178.0
DLETKEDPLFIPPLNFSMVSRGVYRSGYPNKKNHPFLKKLGLKSILYLCPEEY---SESNTNFIRKHGIKLLHYRIVGNKEPFVDIPDEYIRDALVDLLD
.|.. |... ....|.|..  |.|....|. .. ..||.||...|. |..| .    ...  . ...||. ||. |.....| ..   . . ... ..||
llsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald

VRNHPILIHCNKGKHRTGCLVGC-LRKLQKWSYTYIFDEYRRFAGSKVRVLDQQFIELFNLEVPYNKR
 ...|.|.||. |..|.|.|| . | | ...|.  .....|.      .  .......| |..  .. 
ekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllkesd
0051429 (Phosphotyrosine protein) phosphatases II 23-151 3.1e-28 94.6 In-house 15-192 (272) alignment 
Range on Protein: 23-151
Range on HMM: 15-192/272.0
LnFSMVSRG-VYRSGYP---NKKNHPFLKKLGLKSILYLCPEEYSESNTNFIRKHGIKLLHYRIVGNKEPFVD---------------------------
. ...| .| .||||.|   . .. ..||.||.|.|. |..||. ...  .   .||..||. |... .|..                            
y.grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltll

---------------------IPDEYIRDALVDLLDvrNHPILIHCNKGKHRTGCLVGCLRKLQKWSYTYIFDEYRRFAGS
                     .|.|.....|  |||  ..|.|.||. ||.|||..| .|. |. .|.. |.|.|...   
lsagearevmhlhytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly
0042113 (Phosphotyrosine protein) phosphatases II 15-158 2.3e-27 91.4 In-house 32-231 (245) alignment 
Range on Protein: 15-158
Range on HMM: 32-231/245.0
EDPLFIPPLNFSMV-----SRGVYRSGYPNKKNHP----FLKKLGLKSILYLCPEEYSESN---------------------------------------
.  |. .. |.|.|     .........| ... .    .|..||...|. |..||. . .                                       
ggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtn

-TNFIRKHGIKLLHYRIVGNKEPF-VDIPDEYIRDALVDLLDVRNHPILIHCNKGKHRTGCLVGCLR------KLQKWSYTYIFDEYRRFAGSKVRVLDQ
  ..  ...| .... . ....|  ... .. .. ..  | . .|.|.|.||. |..|||.......      |....|   ...|.|.. .  |  ..|
lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsq
0036282 (Phosphotyrosine protein) phosphatases II 21-165 6.4e-26 86.5 In-house 8-164 (174) alignment 
Range on Protein: 21-165
Range on HMM: 8-164/174.0
PPLNFSMVSRGVYRSGYPNKkNHPFLKKLGLKSILYLCPEEYSE---------SNTNFIRKHGIKLLHYRIVGNKEPFVDIPDEYIRDALVDLLDVRNHP
.||..|...........| . . ..||.||..... |..|.. .         .. .. ...||..|.. .... .| ..| .| .. .   |.. ...|
spldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

ILIHCNKGKHRTGCLVGCLRKLQKW--SYTYIFDEYR--RFAGSKVRVLDQQFIELFN
.|.||. |..|||.||.... |. .  |.  ..| .|  |.  ...   ..|.. |  
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyy
0041856 (Phosphotyrosine protein) phosphatases II 20-162 2.1e-24 81.5 In-house 14-163 (182) alignment 
Range on Protein: 20-162
Range on HMM: 14-163/182.0
IPPLNFSMVSRGVYRSGYPN--------------KKNHPFLKKLGLKSILYLCPEEYSEsntNFIRKHGIKLLHYRIVGNKEPFVDIPDEYIRDALVdll
 ........  ..|....|.               .. ..||.|| ..|. |..| |     ..  ..||..|.. . ..  | .|.  ..|...|    
dhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywp...ellerlgiqylylpwpDhgvpdldelldfieevle...

dvRNHPILIHCNKGKHRTGCLVGC-LRKLQKWSYTYIFDEYRRFAGSKVRVLDQQFIE
  ...|.|.||. |..|||.||.. | | ...|.. .....|.     |  ..| |..
..eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyffl
0039614 (Phosphotyrosine protein) phosphatases II 20-175 2.6e-23 78.4 In-house 65-293 (297) alignment 
Range on Protein: 20-175
Range on HMM: 65-293/297.0
IPPLNFSMV--------------------------SRGVYRSGYPNKKN----HPFLKKLGLKSILYLCPEEYSE-------------------SNTNFI
|.|...|.|                          .| ......|....      .....| ..|. |..... .                    .....
ilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkve

RKHGIKLLHYRIVGNKEP-------FVDIPDEYIRDALVDLLDV------------RNHPILIHCNKGKHRTGCLVGCLR------KLQKWSYTYIFDEY
 ..|... . ... |.|.       ....||  . . | .||..            ...|.|.||. |..|||.......      | .....  ...|.
hldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkel

RRFAgSKVRVLDQQFIELFNLEVPYNKRYK
|.   ....  ..|.. |..... . ||..
reqR.pgavqtpsqyrflydallellkrkl
0048179 (Phosphotyrosine protein) phosphatases II 24-158 5e-23 76.9 In-house 3-133 (144) alignment 
Range on Protein: 24-158
Range on HMM: 3-133/144.0
NFSMVSRGVYRSGYPNKKNHPFLKKLGLKSILYLCPEEYSESNTNFirkhGIKLLHYRIVGNKEPFVDIPDEYIRDALVDLLDvRNHPILIHCNKGKHRT
|.|..  |.|....|  .. ..|||||.. .. |..| . |. ...    ||..||. . ..  |      . . ... ..|. ...|.|.||. |..||
npseilpglylgslptaldlellkklgittvinlteeyepeflere....giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRt

GCLVGC-LRKLQKWSYTYIFDEYRRFAGSKVRVLDQ
|.|| . | |....|.  .....|.     |   .|
gtlvaaylmkklglsleealalvrsrrpgavpnpgq
0048076 (Phosphotyrosine protein) phosphatases II 22-154 6.4e-23 76.4 In-house 1-127 (145) alignment 
Range on Protein: 22-154
Range on HMM: 1-127/145.0
PLNFSMVSRGVYRSGYPNKKNHPFLKKLGLKSILYLCPEEYSESntnfirKHGIKLLHYRIVGNKEPfvdiPD-EYIRDALVDL--LDVRNHPILIHCNK
| ..|..  |.|....|. .. ..||.||.. .| |..|.. ..      ..||..|.. . .. .|    .. |.....|  .  .  ...|.|.||. 
pywpseilpglylgslptaldlellkdlgittvlnltselelle......rlgiqylylpwpDhgvp....dllellleflefieealkeggpvlVHCsa

GKHRTGCLVGC-LRKLQKWSYTYIFDEYRRFAGSKVR
|..|||.||.. | .|...|.  .....|.     | 
GvgRtgtlvaaylmlllgvsleealelvrsqrpgavp
0043336 (Phosphotyrosine protein) phosphatases II 20-158 3.9e-21 71.2 In-house 54-265 (278) alignment 
Range on Protein: 20-158
Range on HMM: 54-265/278.0
IPPLNFSMV------------------------SRGVYRSGYPNKKN----HPFLKKLGLKSILYLCPEEYSES--------------------NTNFIR
|.|...|.|                        .|.......|....      ....|| ..|. |..... ..                    ..... 
ilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeeh

KHGIKLLHYRIVGNKEPFVDI----------------PDEYIRDALVDLLDV---RNHPILIHCNKGKHRTGCLVGCLR------KLQKWSYTYIFDEYR
...... . ... ...... .                . . . | | .....   .|.|.|.||. |..|||.......      | .....  ...|.|
lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelr

RFAGSKVRVLDQ
.. .. |  ..|
eqRpgavqtpsq
0040438 (Phosphotyrosine protein) phosphatases II 44-163 2.2e-20 68.6 In-house 104-270 (317) alignment 
Range on Protein: 44-163
Range on HMM: 104-270/317.0
PFLKKLGLKSILYLCPEEYSE---------------------SNTNFIRKHGIKLLHYRIVGNKE--------------PFVDIP-DEYIRDALVDLLDV
 .....|...|. |...|. .                      ..... ..||.|.. .......              |  ..| .  .  ....... 
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

R----NHPILIHCNKGKHRTGCLVGCLR------KLQKWSYTYIFDEYRRFAGSKVRVLDQ-QFIEL
     ..|.|.||. |..|||.......      | ...... ...|.|.. .  |  ..| .|.  
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyd
0045098 (Phosphotyrosine protein) phosphatases II 16-171 2.3e-20 68.6 In-house 13-272 (278) alignment 
Range on Protein: 16-171
Range on HMM: 13-272/278.0
DPLFIPPLNFSMVSRGVYRSGYP-----------------------------------------NKKNHPFLKKLGLKSILYLCPEEYSE----------
   .... ..|... ..|.....                                           ..  .|..|| ..|. |..... .          
fefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

-----------------------------SNT----NFIRKHGIKLLHY-RIVGNKEPFVD--IPDEYIRDALVDLLDV-------------RNHPILIH
                              |.    . . ..|.. |||  .  .  |  .   .   . . . . |..             ...|.|.|
ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVH

CNKGKHRTGCLVGCLRKLQ----KWSYTYIFDEYRRFAGSKVRVLDQQFIELFNLEVPYN
|. |..|||.||..   |.    ....  ...|.|.  .  .    .|.. |. ... . 
CsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
0049772 (Phosphotyrosine protein) phosphatases II 25-158 3.5e-19 65.1 In-house 155-268 (314) alignment 
Range on Protein: 25-158
Range on HMM: 155-268/314.0
FsmvsrgvyrsGYPNKKNHPFLKklglksilylcpE-EYSEsntNFIRKHGIKLLHYRIVGNKEPfvdiPDEYIRDALVDLLDV-RNHPILIHCNKGKHR
.          ..|. .. ..||            |  |.    ..  ..|||.|.. . .. .|    ..|.....|  .... ...|.|.||. ||.|
g..........neptaadlellk............eelydp...elferlgikylripvpDgsap....lledfdeflefieeadkggpvlvHCkaGkgR

TG--CLVGCLRKLQKWSYTYIFDEYRRFAG-----SKVRVLDQ
||  .....| ||...|.  .....|.        . .. |.|
tgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleq
0040439 (Phosphotyrosine protein) phosphatases II 20-158 7.8e-19 63.7 In-house 20-234 (249) alignment 
Range on Protein: 20-158
Range on HMM: 20-234/249.0
IPPLNFSMVSRGVYRSGYPN----------------------------KKNHPFLKKLGLKSILYLCPEEYSESNTNF----------------------
|.|...|.|  .........                            ...  .|..|| ..|. |..... . .. .                      
ilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsve

---------------IRKHGIKLLHYRIVGNKepFVDIP-DEYIRDALVDLLDV------RNHPILIHCNKGKHRTGCLVGCLR------KLQKWSYTYI
                 .  .. ||.....      ..| .  . ........       ...|.|.||. |..|||......       | .....  .
vkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleea

FDEYRRFAGSKVRVLDQ
....|.  .  |  ..|
vkllrsqRpgavqnpeq
0037934 (Phosphotyrosine protein) phosphatases II 20-153 9.5e-19 63.4 In-house 34-224 (243) alignment 
Range on Protein: 20-153
Range on HMM: 34-224/243.0
IPPLNFSMVSRGVYRSGYPNKK--------NHPFLKKLGLKSILYLCPEE---------------------------------------YSESNTNFIRK
  ..|...| ........| ..        .  .|..|| ..|. |....                                       ..  ...   .
yinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltr

HGIKLLHYRIVGNKEPF--------VDIPDEYIRDALVDLLDVRNHPILIHCNKGKHRTGCLVGCLRKLQ--KWSYTYIFDEYRRFAGSKV
..|..... . ... |         .|.  |.|...|  | . ...|.|.||  |..|||.|. ..  |.  ....  .....|.  . |.
lvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgka
0043147 (Phosphotyrosine protein) phosphatases II 34-153 1.4e-15 52.9 In-house 28-144 (172) alignment 
Range on Protein: 34-153
Range on HMM: 28-144/172.0
RSGYPNKKNHPFLKKLGLKSILYLCPEeysESNTNFIRKHGIKLLHYRIVGNKEPFVDIPDEYIRDALVDLLDVRNHPILIHCNKGKHRTGCLVGCLRKL
  ...  ..  .||.|| . |. |...   . .. .  ..||..|.. .  .  |  .. .| ..     |.  ...|.|.||  |. |||.|| ..  |
plrntladfwrmlkelgithivnltel...lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml

QKWSYTYIFDEYRRFAGSKV
...|.  .....|.  .  |
lglsleeavalvrekRpgav
0045450 (Phosphotyrosine protein) phosphatases II 25-155 6.9e-15 51.0 In-house 91-289 (307) alignment 
Range on Protein: 25-155
Range on HMM: 91-289/307.0
FSMVSRGVYRSGYPNKKNH---------------PFLKKLGLKSILYLCPEEYSES----------------------NTNFIRKHGIKLLHYRIV---G
. .| ......|| .|..                 .|...| . |. |..... ..                      ....  ..|........    |
yvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldg

NKE------------PFVDIP-DEYIRDALVDLLDV------RNHPILIHCNKGKHRTGCLVGCLRKLQK---------WSYTYIFDEYRRFAGSKVRV
..|            |  ..| .  .  .......       ...|.|.||. |. |||......  |.          ...  .....|.  .  |  
tgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqn
0046846 (Phosphotyrosine protein) phosphatases II 20-159 2.8e-14 48.7 In-house 7-161 (176) alignment 
Range on Protein: 20-159
Range on HMM: 7-161/176.0
IPPLNFSMVSRGVYRSGYP----------NKKNHPFLKKLGLKSILYLCPEE-----YSESNTNFIRKHGIKLLHYRIVGNKEPFVDIPDEYIRDALVdL
...|... .  ... ...|            ..  .||.|| . .. |. |            . ..|.||. ||. .. .  |  .. .| ..      
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefire.a

LDvRNHPILIHCNKGKHRTGCLVGCLRKLQ--KWSYTYIFDEYRRFAGSKVRVLDQQ
|. ...|.|.||  |. |||.|| ..       .|.  .....|.    ..   ..|
lk.eggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQ
0049260 (Phosphotyrosine protein) phosphatases II 33-147 4.5e-14 47.9 In-house 16-127 (152) alignment 
Range on Protein: 33-147
Range on HMM: 16-127/152.0
YRSGYPNKKNHPFLKKLGLKSILYLCPEEYsesNTNFIRKHGIKLLHYRIVGNKEPFVDIPDEYIRDALVDLLDVRNHPILIHCNKGKHRTGCLVGCLRK
.  ... ...  .||.|| . |. |. ...   .. .  ...|. ||. .  .  |  ..  . . ...  |.  ...|.|.||  |. |||.|| ..  
gpgpntladfwrmlkelgittivmltelle...lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

LQKWSYTYIFDEYRR
|...|.  ... .|.
llgvsleeavalvre
0036941 (Phosphotyrosine protein) phosphatases II 46-148 4.4e-11 38.1 In-house 98-255 (297) alignment 
Range on Protein: 46-148
Range on HMM: 98-255/297.0
LKKLGLKSILYLCPEEY----------SESNTNFIRKHGIKLLHYRIVG-----------------------------NKEPFVDIPD-EYIRDALVDLL
. ... ..|. |....           .. . ...  .....   ..                                . |  ..|.  ..  ....|.
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

DV------RNHPILIHCNKGKHRTGCLVGCLR---------KLQKWSYTYIFDEYRRF
.       ...|.|.||. |..|.|.....           | .....  .. ..|. 
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReq
0038934 (Phosphotyrosine protein) phosphatases II 45-153 3.6e-10 35.3 In-house 51-160 (194) alignment 
Range on Protein: 45-153
Range on HMM: 51-160/194.0
FLKKLGLKSILYLCPEEYSEsNTNFIRKHGIKLLHYRIVGN-KEPFVDIPDEYIRDALVDLLDVRNHPILIHCNKGKHRTGCLVGC-LRKLQKWSYTYIF
 |.. .|  .. |. .|    ... . |.||. |.. ...    |  .| ..... . . | .  .. ...||  |. |||.||.. | . ...|.    
kllnvklglvidltnteryY.dpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAi

DEYRRFAGSKV
. .|.  .. .
alfrekRpgai
PTEN_1 27-147 1.7e-08 29.5 In-house 43-169 (196) alignment 
Range on Protein: 27-147
Range on HMM: 43-169/196.0
MVSRGVYRSGYPNKKNHP-FLKKLGLKSILYLCPEE-Y--SESNTNFIRKHGIKLLHYRIVGNKEPFVDIPDEYIRDALVDLLDVR-NHPILIHCNKGKH
 .. |.||  ..   ..   ||. |. ... |..|| .   . . .. .|.|.. ||. |     |  .   . ....   ||  . .. .|.||  |. 
eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlg

RTGCLVGC-LRKLQKWSYTYIFDEYRR
|.|..| . | ...|...   .. .|.
RsGtvvaayLmykgkltadeAlelvre
subfamily_DSP23_pd Subfamily DSP23 21-170 2.5e-08 28.7 In-house 1-145 (148) alignment 
Range on Protein: 21-170
Range on HMM: 1-145/148.0
PPLNFSMVSRGVYRSGYPNKKNH-PFLKKLGLKSILYLCPEEYSESNTNfirkHGIKLLHYRIVGNKEPFVDIPDEYIRdaLVDLLDVRNHPILIHCNKG
.| .|| ||  .   . |.  ..  .|  ||.. .. |  |   ....      .. | . ||   . | ..  .|..|  .|.  . .|  . .|| .|
qppffswvssrlaalalprlpdqyrylldlgvrylvslteegrphveat....pnltlvrlriddyhppaleqvvefvr..vveeaeekneavsvhcllg

KHRTGCLVGC-LRKLQKWSYTYIFDEYRRFAGSKVRVLDQQFIeLFNLEVPY
. ||| .. | | | .| . .    | ||     |  ..|. . ... |. .
rgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqekl.vrdyetfi
0047943 (Phosphotyrosine protein) phosphatases II 91-143 4.3e-08 28.4 In-house 180-239 (273) alignment 
Range on Protein: 91-143
Range on HMM: 180-239/273.0
DIP-DEYIRDALVDLLDV------RNHPILIHCNKGKHRTGCLVGCLRKLQKWSYTYIFD
..| .  .   ...|..       .|.|...||. |. |||... ..  |. . ... .|
gvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd
Y_phosphatase3 Tyrosine phosphatase family 91-146 5.1e-08 28.1 Pfam-A 107-161 (164) alignment 
Range on Protein: 91-146
Range on HMM: 107-161/164.0
DIPDEYIRDALVDLLDVRnHPILIHCNKGKHRTGCLVGCLRKLQKWSYTYIFDEYR
. . . .|..|  |.. . .|.|.||  || ||| ..  | .|   . . |...| 
edekkayrkvlealaeee.gpvlfHCtaGKDRTGvvaalllsllgvdeetiaaDYl
0050432 (Phosphotyrosine protein) phosphatases II 99-144 6.7e-08 27.7 In-house 220-267 (308) alignment 
Range on Protein: 99-144
Range on HMM: 220-267/308.0
DA--------LvdlldvRNHPILIHCNKGKHRTGCLVGCLRKLQKWSYTYIFDE
 .        |      ...||..||. |  |||... ..  |. . ... .| 
ldflelvrksl......pggpivVHCsaGvGRtGtfialdllleqlekeggvdv
0051299 (Phosphotyrosine protein) phosphatases II 93-144 1.7e-07 26.5 In-house 193-254 (288) alignment 
Range on Protein: 93-144
Range on HMM: 193-254/288.0
PDEYIRDAL--------------VdlldVRNHPILIHCNKGKHRTGCLVGCLRKLQKWSYTYIFDE
||  . | .                    ...|...||. |. |||... ..  |. . ... .| 
pdhgvpdspellldflrlvrkala....sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdv
0046845 (Phosphotyrosine protein) phosphatases II 99-148 2.7e-07 25.7 In-house 200-252 (284) alignment 
Range on Protein: 99-148
Range on HMM: 200-252/284.0
DalvdllDVRNHPILIHCNKGKHRTGCLVGCLRKLQ---------KWSYTYIFDEYRRF
.        ...||..||  |. |||... .   |.         ....  ..  .|. 
n......lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreq
PTPc_motif_SM00404 26-128 8.1e-07 24.0 In-house 3-99 (140) alignment 
Range on Protein: 26-128
Range on HMM: 3-99/140.0
SMVSRGVYRSGYPNKKNHPFLKKLGLKSILYLCPEEYSESNTNFIRKHGIKlLHYRIVGNKEPFVDIPDEYIRDAlvdllDVRNHPILIHCNKGKHRTGC
| .....| .......| ..|||||.. .. .  |   ..... ..   |. |.   . .  .. |   ..|..|       ... .|.||  |  |...
srilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqip.lddnekdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSat

LVG
|. 
lii
DSPc Dual specificity phosphatase, catalytic domain 33-129 2e-06 22.7 Pfam-A 2-93 (133) alignment 
Range on Protein: 33-129
Range on HMM: 2-93/133.0
YRSGYPNKKnHPFLKKLGLKSILYLCPEEYS--ESNTNFIRKHGIKlLHYRIVGNKEPFVDIPDEYIRDAlvdllDVRNHPILIHCNKGKHRTGCLVGC
| .......  ..|.|||.. .. .  |     ..... |.. .|. ..     . ... .   |.|..|     . ... .|.||. |  |...|. .
ylgskstas.lalleklgitlvinvtkevpnnnaikkseieylrip.vedetetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliia
DSPc Dual specificity phosphatase, catalytic domain 33-129 2e-06 22.7 In-house 2-93 (133) alignment 
Range on Protein: 33-129
Range on HMM: 2-93/133.0
YRSGYPNKKnHPFLKKLGLKSILYLCPEEYS--ESNTNFIRKHGIKlLHYRIVGNKEPFVDIPDEYIRDAlvdllDVRNHPILIHCNKGKHRTGCLVGC
| .......  ..|.|||.. .. .  |     ..... |.. .|. ..     . ... .   |.|..|     . ... .|.||. |  |...|. .
ylgskstas.lalleklgitlvinvtkevpnnnaikkseieylrip.vedetetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliia
subfamily_CDC14_pd Subfamily CDC14 43-130 9.8e-06 19.6 In-house 205-284 (328) alignment 
Range on Protein: 43-130
Range on HMM: 205-284/328.0
HPFLKKLGLKSILYLCPEEYSESNtnFiRKHGIKllHYRIVgnkepFVD--IPDEYIRDALVDLLDVRNHPILIHCNKGKHRTGCLVGCL
 .. .| ...... |  . | ...  |  ..|..  |. ..     |.|  .|.. |   ......  .  | .||  |  |||.|..| 
leyfrknnvttvvrLnkklYdakk..f.tdaGfd..hkDlf.....fiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacy