Gene cnrN in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP039_AA protein Get Run
DdisP039_AA_11-189 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTEN_pd Subfamily PTEN 9-189 2.3e-76 250.8 In-house 2-181 (184) alignment 
Range on Protein: 9-189
Range on HMM: 2-181/184.0
IRSLVSADRHRFKSKemDLDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNL-SERVYDYSKLNNQILEFPFLDHHPPPLSLLF
.|..||....|||..  .|||||||||.||.|||.| ..||| .|||..||...|..||...|.|.|| ||| ||..|..... ..|| ||.||||.|| 
lrkivskkkkrfked..gldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelle

EIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRSKMKKGVTQPSQQRYINYFKEIVSG
|||.....||..| .||.||||| ||||||..|..||..|...| ...|...|||.|.|.||||| |||.||..|...... 
eivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekllee
subfamily_Tensin_pd Subfamily Tensin 24-193 2.7e-55 179.8 In-house 6-178 (189) alignment 
Range on Protein: 24-193
Range on HMM: 6-178/189.0
EMDLDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAEN
|   ||||.|||. |.|. ||..|||...|... ||..|||.||. ||...||||. || ||||...|.| . |.. |.|  |  |..|| .||||| .|
eekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqn

VAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRS--KMKKGVTQPSQQRYINYFKEIVSGS-HMV
|.||||||||||.| .. .|. ||   .  | | ..|| ||   .  .|.|||||.||..||....||. .. 
vvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkikln
subfamily_VSP_pd Subfamily VSP 8-187 4.9e-50 164.4 In-house 15-198 (212) alignment 
Range on Protein: 8-187
Range on HMM: 15-198/212.0
KIRSLVSADRHRFKSKEMdlDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNL-SERVYDYSKLNNQILEFPFLDHHPPPLSLL
 .| ||| .. |..   .  ||||.|.|. |.|| || .| .. .|| |..|. .|..||. .| . || ||| || . .||.. .    ||  | |. |
aarrlvsenkrrytqdGf..dldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleel

FEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRS-----KMKKGVTQPSQQRYINYFKEIV
. . . . .||..| .|| ..||||||||||||.|..| .| .||  ... ..|.|.|.     .. .||  |||.||..|.....
lvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvk
PTEN_1 14-188 1.8e-45 150.2 In-house 5-193 (196) alignment 
Range on Protein: 14-188
Range on HMM: 5-193/196.0
SADRHRFKSKEMDLDLDLSYITDNILAMG-FPGTG-----LEASWRNSIDDVCELLKQKHHGK-YMIWNLSERV------YD---YSKLNNQILEFPFLD
| ..   .. . ...|||.|||. |.||| .|...      |  .|.|..|| ..|..... . ....||||.       ||   . | . . |.||. |
skrsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieD

HHPPPLSLLFEIVNSLSNWLKADA-ENVAVVHCKGGKGRTGTIICCYLYYSCQfEIMDDAKNHFAEKRSKMKKGvtQPSQQRYINYFKEIVS
|..|.|| ||.|..|. .||..|  .||..||||.|.||.||....|| |. .   .|.|  ...|||... .   .|||.|...||.|. .
hgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaella
subfamily_Auxilin_pd Subfamily Auxilin 28-188 9.3e-45 145.3 In-house 8-165 (166) alignment 
Range on Protein: 28-188
Range on HMM: 8-165/166.0
DLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVV
|||.||||  |. | ||  |.| ...|.|||| . |  .|..||...|||.| |. .||.....|  .  .. |.|. |.|.   | .|||.| .|| ||
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvv

HCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRSKMKkgvTQPSQQRYINYFKEIVS
||| |.  ...... .| .   ..  ..| . |. ||  .     .||..||..|. ....
hckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladlla
0036282 (Phosphotyrosine protein) phosphatases II 28-189 4.7e-41 135.7 In-house 9-171 (174) alignment 
Range on Protein: 28-189
Range on HMM: 9-171/174.0
DLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLS-ERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAV
.|||||||....|...| . .|  ....| .|  ||. |. |.|...|.  |. .|...|. |.| .|. ||..|.|| |.|.|. . ..|. | ... .
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

VHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRSKMKKGVTQPSQQRYINYFKEIVSG
|||..|.|||||....|| . ...| ..|| ....|.|..  ..|. ||| |.. ||. ..||
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsg
0038934 (Phosphotyrosine protein) phosphatases II 33-183 5.9e-37 122.6 In-house 15-166 (194) alignment 
Range on Protein: 33-183
Range on HMM: 15-166/194.0
YITDNILAMGFPGTG-----LEASWRNSIDDVCELLKQKHHGKYMIWNLS--ERVYDYSKLNN---QILEFPFLDH-HPPPLSLLFEIVNSLSNWLKADA
.||....|...| .|     .|  .|.|..|....||..... .....|.  ||.||.... .   ..|..|| |. ..|.|..|..... .  .|..|.
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

ENVAVVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFAEKRskmkkgvtqPSQQRYINYF
..| .||||.|.|||||....|| |....  ...| ..|.|||         |.. ....|.
ggvvaVHCkaGlgRtGtlvaaYLiyrlgms.aeeAialfrekR.........pgaipnqdyl
0046846 (Phosphotyrosine protein) phosphatases II 25-185 1.8e-33 111.1 In-house 6-170 (176) alignment 
Range on Protein: 25-185
Range on HMM: 6-170/176.0
MDLDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQkhhGKYMIWNLSERV-----------YDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSL
. |||||.||..|......|... .  .|.  |.. .|...   | ... || |.|            .. ||. |.| .|. ||..|.|.||.|... .
lgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefi

SNWLKADaeNVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRSKmkKGVTQPSQQRYINYFKE
 ..||..  .. .|||..|.|||||....|| .. ..  ...|  .. |.|..  . |. |.| |.. .|  
realkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefel
0041856 (Phosphotyrosine protein) phosphatases II 25-183 1e-30 102.1 In-house 13-166 (182) alignment 
Range on Protein: 25-183
Range on HMM: 13-166/182.0
MDLDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKY-MIWNLSERVYDYSKLNN---QILEFPFLDHHPPPLSLLFEIVNSLSNwlkad
.| ..||.||..|......|.|  .| ... ...| . |.. .. .. .|.||.|. |....|..   |.| .|. ||..|.|. |.....   .     
ydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....

AENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDdAKNHFAEKRSKmkkGVTQPSQQRYINYF
 ... .|||..|.|||||....|| ..... . . | ... ..|..   .|..|.| ... ..
eggpvlVHCsaGvgRtgtlvaaylmkklgvslee.avklvrsrRpg...mvitpnqyfflqla
0037934 (Phosphotyrosine protein) phosphatases II 24-183 1.8e-30 101.7 In-house 32-237 (243) alignment 
Range on Protein: 24-183
Range on HMM: 32-237/243.0
EMDLDLDLSYITDNILAMGFPGTGLEAS---------WRNSIDDVC----------------------------ELLKQKHHGKYMIWNLSERV---YDY
.  ....|.|.|... |...| ..  ..         |.. |. ..                            .||...|...|....|. .    .|.
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

SKLNNQILEFPFLDHHPPP-LSLLFEIVNSLSNWLKA-------DAENVAVVHCKGGKGRTGTIICCYLYYSC-QfEIMDDAKNHFAEKRSKmkKGVTQP
..|. ... .|. ||..|.  . | .... . .....       | ... .|||..|.|||||.|..|| ... .   ...| ... |.|.   |.|. |
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg.vdleeavkllreqRpg..kavqtp

SQQRYINYF
|| |.. ..
sqyrflyea
0043147 (Phosphotyrosine protein) phosphatases II 28-185 8.4e-30 99.1 In-house 12-158 (172) alignment 
Range on Protein: 28-185
Range on HMM: 12-158/172.0
DLDLSYITDNILAMGFPgtgleasWRNSIDDVCELLKQKHHGKymIWNLSER---VYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENV
.|||.||.|...|. .|       .|| ..|. ..||... .   |.|| |.    .....|. |.| .|. ||..|.|.|| |... . ..|  . ...
yldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggp

AVVHCKGGKGRTGTIICCYLYYsCQFeIMDDAKNHFAEKRskmKKGVTQPSQQRYINYFKE
 .|||..|.|||||....|| . ...  ...| ... |||    ..|. |||.|.. || .
vlVHCsaGvgRtgtlvaaylml.lgl.sleeavalvrekR...pgavqnpsqyrflyyfek
0039614 (Phosphotyrosine protein) phosphatases II 14-183 4.4e-29 97.3 In-house 56-284 (297) alignment 
Range on Protein: 14-183
Range on HMM: 56-284/297.0
SADRHRFK------------SKEMDLDLDLSYI-----------TDNILAMGFPGTG-----LEASWRNSIDDVC-------------------------
. |..|.|            . |.. |||..||           |....|...| ..     ..  |.. .  .                          
nkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygd

---ELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPFLDHHPPP-LSLLFEIVNSLSNWLKAD-AENVAVVHCKGGKGRTGTIICCYLY-----YSCQF
   .||| .|.. |....|. . ...|.  .... ... ||..|| |.||.|... . ..|...  ... .|||..|.|||||.|..||      . ...
ftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

EiMDDAKNHFAEKRskmKKGVTQPSQQRYINYF
  ...| ... |.|    ..|. ||| |.. ..
d.vleavkelreqR...pgavqtpsqyrflyda
0042113 (Phosphotyrosine protein) phosphatases II 12-183 1.7e-27 91.8 In-house 18-238 (245) alignment 
Range on Protein: 12-183
Range on HMM: 18-238/245.0
LVSADRHRFKSKEMDLDLDLSYI----------TDNILAMGFPGTGLEA-----SWRNSIDDVC------------------------------ELLKQK
 .  |. |.| .... |||..||          |....|...| ..  .      |.. |  ..                              .||. .
ilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllsee

HHGKYMIWNLSER--VYDYSKLNNQILEFPFLDHHPPP-LSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLY-----YSCQFEiMDDAKN
|...|....|.     .|.|. ..... .|. ||..|. |.||..... . ..|..|.... .|||..|.|||||.|..||      . . .  ...|  
hlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs.leeavk

HFAEKRskmKKGVTQPSQQRYINYF
.. ..|    . |. ||| |.. ..
elrsqR...pgavqtpsqyrflyea
0049260 (Phosphotyrosine protein) phosphatases II 40-186 3.4e-27 90.4 In-house 6-148 (152) alignment 
Range on Protein: 40-186
Range on HMM: 6-148/152.0
AMGFPGTGLEASWRNSIDDVCELLKQKHHGKY-MIWNLSERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGT
||.|. .. .. ..|...|. ..||. . . . |...|.|. ... .   |.| .|. ||..|.|| |..... . ..|. | ... .|||..|.|||||
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

IICCYLYYscqfeIMDDAKNHFAEKRSKMKKGVTQPSQQRYINYFKEI
....|| .        .... .|  |.| ...|. |.| |.. .| ..
lvaaylml.....lgvsleeavalvrekRpgavpnpgqlrflyefekl
0043336 (Phosphotyrosine protein) phosphatases II 12-183 1.2e-26 89.2 In-house 54-272 (278) alignment 
Range on Protein: 12-183
Range on HMM: 54-272/278.0
LVSADRHRFKSKEMDLDLDLSYI----------TDNILAMGFPGTGLEASWRNSIDD----------------------------------VCELLKQKH
 .  |..| | . .. |||..||          .....|...| .. .. ... . .                                  . .|||..|
ilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeeh

HGKYMIWNLSER--VYDYSKLNNQILEFPFLDHHPP-PLSLLFEIVNSLSNWLKaDAENVAVVHCKGGKGRTGTIICCYLYY-SCQFEIMDDAKNHFAEK
.. |....|      ...|.  ...  ... ||. | .||||..... . ..|. | ... .|||..|.|||||.|..|| .   . |   |. . ..| 
lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

RSKMKKGVTQPSQQRYINYF
|..  . |. ||| |.. ..
reqRpgavqtpsqyrflyea
0051082 (Phosphotyrosine protein) phosphatases II 29-183 4e-26 86.8 In-house 6-147 (151) alignment 
Range on Protein: 29-183
Range on HMM: 6-147/151.0
LDLSYITDNILAMGFPgtgLEaswrnsidDVCELLkqKHHGKYMIWNLSERV---YDYSKLNN---QILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAE
...||.|......|.|   |.        |. |||  |..| ..| || . .   |... |..   ..| .|.||...|.|.|.|..|... ..| .. .
infsyvtgglyrsggp...la........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVAVVHCKGGKGRTGTIICCYLYYscQFEIMDDAKNHFAEKRSkmkkGVTQPSQQRYINYF
.. .|||..|||||||....|| .  .   ...| ... .||     ||.||.||... .|
gpvlvHCsaGkgRTGtlvalylml..lgvsleealeeyrlkrp....gvvqpnqqflfqlf
0048076 (Phosphotyrosine protein) phosphatases II 44-184 1.2e-25 85.3 In-house 4-139 (145) alignment 
Range on Protein: 44-184
Range on HMM: 4-139/145.0
PGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPFLDHHPPPL-SLLFEIVNSLSNWLKADaeNVAVVHCKGGKGRTGTIICC
|   |.  ...|. ....|   |..| ....||.   .....|. |.| .|. ||..|.| .|| |... . ..||..  .. .|||. |.|||||....
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaa

YLYYSCQFEiMDDAKNHFAEKRSKmkkGVTQPSQQRYINYFK
|| .....  ...| ... ..|..   .|. |.|.|.. .| 
ylmlllgvs.leealelvrsqrpg...avpnpgqlrflyefe
0044763 (Phosphotyrosine protein) phosphatases II 26-185 7.1e-25 83.1 In-house 18-168 (178) alignment 
Range on Protein: 26-185
Range on HMM: 18-168/178.0
DLDLDLSYITDNILAMGFPGTG-LEASWRNSIDDVCELLKQKHHGkymiwNLSERVYDYSKLNNQILEFPFLDHHPPP-LSLLFEIVNSLSNWLKADAeN
   ...|.|.........|    ||  ... |. .. | . ...|      |..  |.... . | | .|. ||..|. |. ..|.|. . ..|. .  .
sdyinaseilpglylgslppaddlellkelgithivnlteelelg.....flkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg.g

VAVVHCKGGKGRTGTIICCYLYYSCQFeIMDDAKNHFAEKRskmKkGVTQPSQQRYINYFKE
. .|||. |.||.||....|| .....  ...| ... |.|     .|. |.|.|.. .| .
pvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR...p.ivpnpgqlrqLyefel
0048179 (Phosphotyrosine protein) phosphatases II 44-185 9.3e-25 82.4 In-house 4-142 (144) alignment 
Range on Protein: 44-185
Range on HMM: 4-142/144.0
PGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLSERVYDYSKLNN--QILEFPFLDHHPPPL-SLLFEIVNSLSNWLKADaeNVAVVHCKGGKGRTGTII
|   |.  ...|. ....|   |..| ....||.|  . ..  ..  |.| .|. ||..|.| .|| |... . ..|. .  .. .|||..|.|||||..
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlv

CCYLYYSCQFEiMDDAKNHFAEKRSkmkKGVTQPSQQRYINYFKE
..|| . ...  ...| ... ..|.    .|. |.| |.. .. .
aaylmkklgls.leealalvrsrrp...gavpnpgqlrfLleyek
0045098 (Phosphotyrosine protein) phosphatases II 24-183 9.7e-23 76.4 In-house 2-267 (278) alignment 
Range on Protein: 24-183
Range on HMM: 2-267/278.0
EMDLDLDLSYITDNILAMGFPGTGLEASWRNSID------------------------------------------------------------------
| . .|||.......|..|.|.. ..| .....|                                                                  
ealasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-------------------------DVCELlKQKHHGKYMIWNLSERVYDYSKLNNQILEF-PFLDHHPPPLS---LLFEIVNSLSNWLK----------
                         ....| .  .. .....||. . .|. ... ..| . |. ||..|.|.    ..|... . ..||          
grekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

--ADAENVAVVHCKGGKGRTGTIICCYLYYSC---QFEiMDDAKNHFAEKRskmKK-GVTQPSQQRYINYF
   | ... .|||. |.|||||....|| ...   ..  ...| ... ..|       |. ..|.|.. .|
llldsggpvlVHCsaGvgRtGtlvaaylmlelleggvd.lleavkelrsqR...pglavqnleqyrflyef
0045450 (Phosphotyrosine protein) phosphatases II 31-183 1.9e-21 72.5 In-house 107-299 (307) alignment 
Range on Protein: 31-183
Range on HMM: 107-299/307.0
LSYI----------------------------------TDNILAMGFPGTGLEASWRNsidDVCELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPF-
. .|                                  .... |. .| .| |  ..|   .. .||. .|...| ...|    .|...   ..  |.. 
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

--LDHHPPP-LSLLFEIVNSLSNWLKAD-AENVAVVHCKGGKGRTGTIICCYLYYSCQ--------FEiMDDAKNHFAEKRskmKKGVTQPSQQRYINYF
   ||. || .. |..... . ..|...  ... .|||..|.|||||.|..|| ...         .  ...| ... |.|    ..|. |.| |.. ..
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd.lleavkllreqR...pgavqnpeqyrflyea
0049772 (Phosphotyrosine protein) phosphatases II 44-184 1.5e-20 69.6 In-house 155-274 (314) alignment 
Range on Protein: 44-184
Range on HMM: 155-274/314.0
PgtgleaswrnSIDDVCELLKQKhhgkymiwnlsERV---YDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWlkaDAENVAVVHCKGGKGRTGT-I
.          .. ....|   |           |..    ....|. . | .|. |...|.|. . |... . ..   |.... .||||.||||||| .
g..........neptaadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfv

ICCYLYYSCQFeIMDDAKNHFAEKRSKMKKGVTQPSQQRYINYFK
...|| . ...  ...| ... .||.   . .. .....|.....
vaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefile
0040438 (Phosphotyrosine protein) phosphatases II 14-183 1.9e-20 68.8 In-house 54-271 (317) alignment 
Range on Protein: 14-183
Range on HMM: 54-271/317.0
SADRHRFKSKEMDLDLDLSYI----------TDNILAMGFPGtgleaswRNSIDDVCELLKQ------------K-----------------HHGKYMIW
  |. | | . .. |||..||          .....|...|         |...|  .....            .                 ..|.....
pydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.......pntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvt

NLSERVydysKLNNQILEFPF-------------------LDHHPPP-LSLLFEIVNSLSNWLKaDAENVAVVHCKGGKGRTGTIICCYLY-----YSCQ
.||| .    . . .......                    ||..|| ..||..... . ..|. | ... .|||..|.|||||.|..||      . ..
llseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekegg

FEiMDDAKNHFAEKRskmKKGVTQPSQQRYINYF
.  ...| ... |.|    ..|. |.| |.. ..
vd.veeavkelreqR...pgavqtpeqyrflyda
0040439 (Phosphotyrosine protein) phosphatases II 29-183 5.9e-20 67.4 In-house 47-241 (249) alignment 
Range on Protein: 29-183
Range on HMM: 47-241/249.0
LDLSYITDNILAMGFPGTGLEASWRNSIDD-----------------------------------VCELLKQKHHGKYMIWNLSER--VYDYSKLNNQIL
.|..||.....|...| ..  ..... . .                                   . .||. .....|....|      .. |   ..| 
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

EFPFLDHHPP-PLSLLFEIVNSLSNWLKAD-AENVAVVHCKGGKGRTGTIICCYLY-----YSCQFEimddAKNHFAEKRSKMKKGVTQPSQQRYINYF
 ... ||. |  .. |..... . ..|...  ... .|||..|.|||||.|..||      . ...     ... ... ||.  ..|. |.| |.. ..
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd....leeavkllrsqRpgavqnpeqyrflyea
0046845 (Phosphotyrosine protein) phosphatases II 28-183 2.8e-19 65.0 In-house 69-269 (284) alignment 
Range on Protein: 28-183
Range on HMM: 69-269/284.0
DLDLSYITDNILAMGFPGTG-----------------------------LEASWRNSIDDVCEL-------LKQKHHGKYMIWNLSERVYDYSKLNNQIL
||||.||. ...|. .|  .                               | .......| ..       |. .... |....|. . ..|..   .. 
dldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvt

EFPFL---DHHPPP-LSLLFEIVNSLSNWLKA-DAENVAVVHCKGGKGRTGTIICCYLYYSCQ-FEI---MDDAKNHFAEKRSKMKKGVTQPSQQRYINY
 | ..   ||. || .. |.|... . ..|.. . ... ||||..|.|||||.|...| ...   |    . |. . ..  |..    |....| |.. .
hfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvye

F
.
a
0047943 (Phosphotyrosine protein) phosphatases II 60-182 3.7e-19 64.7 In-house 139-266 (273) alignment 
Range on Protein: 60-182
Range on HMM: 139-266/273.0
CELLKQKHHGKYMIWNLSERV--YDYSKLNNQILEFPFLDHHPP-PLSLLFEIVNSLSNWLKAD-AENVAVVHCKGGKGRTGTIICCYLYYSCQ-FEIMD
 .||...... |....|  .   ...|.  .... ... ||. |  |. |.|... . ..|.|.  ... ||||..|.|||||.|...| ...   | . 
vtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggv

DAKNHFAEKRSKMKKGVTQPSQQRYINY
|... ..  ||.   .|. |.| |.. .
dvleavkllrsqRpgmvqtpeqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 61-181 1.2e-17 59.8 In-house 152-279 (288) alignment 
Range on Protein: 61-181
Range on HMM: 152-279/288.0
ELLKQKHHGKYMIWNLSERVYD---YSKLNNQILEFPFL---DHHPPP-LSLLFEIVNSLSNWLKaDAENVAVVHCKGGKGRTGTIICCYLYYSC-QFEI
.||. .....|....|  . .|   ...   ..  | ..   ||. |. ..||..... . ..|. . ... ||||. |.|||||.|...| ... ..| 
tllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeg

MDDAKNHFAEKRSKMKKGVTQPSQQRYIN
. |. . ..  |..    |. |.| |.. 
gvdvleavkrlreqRpgmvqtpeqyrfvy
0050432 (Phosphotyrosine protein) phosphatases II 65-180 1.6e-14 49.4 In-house 162-291 (308) alignment 
Range on Protein: 65-180
Range on HMM: 162-291/308.0
QKHHGKYMIWNLSERVYDYSKLNNQILEF-----------------PflDHHPPP-LSLLFEIVNSLSNWLkadAENVAVVHCKGGKGRTGTIICCYLYY
 ...||. . .||| |.|. .. . .|..                 |  ||. || .. |..... . ..|    ... ||||. | |||||.|...| .
sleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp..dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdlll

SCQ-FEIMDDAKNHFAEKRSKMKKGVTQPSQQRYI
..   | . |. . ..  |..    |. |.| ...
eqlekeggvdvfeavkklReqRpgmvqtpeqylfl
0036941 (Phosphotyrosine protein) phosphatases II 65-183 2.5e-14 48.7 In-house 131-272 (297) alignment 
Range on Protein: 65-183
Range on HMM: 131-272/297.0
QKHHGKYMIWNLSERV-----------------YDYSKLNNQILEFPFLDHHPPP-LSLLFEIVNSLSNWLKAD-AENVAVVHCKGGKGRTGTIICCYLY
 . .|......||. |                 ...|.  ...  .   ||..|.  . |..... . ..||.   ... .|||..|.||.||.|...| 
sltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlm

--------YSCQFEimddAKNHFAEKRSKMKKGVTQPSQQRYINYF
        . ...      .. . . |..    |....| |.. ..
lqqledklkeggvd....ileavkklReqRpgavqtleqyrflyea
subfamily_PTPMT1_pd Subfamily PTPMT1 71-184 1e-12 42.8 In-house 57-165 (171) alignment 
Range on Protein: 71-184
Range on HMM: 57-165/171.0
YMIWNLSERVYDYSKLNNQILEFPFLDHH-PPPLSLLFEIVNSLSNWLKadAENVAVVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFAEKRSKMKK
| .  |.. . ...||. ..|...  |.   | |  |.. |. ...  .    .   ||||.|.||..|.. ||| .. ... ...| .. ..||.....
yelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvas..kgkrvYvHCkaGrgRsatlvacylmkkekls.peeAlkalkkkRkiirl

GVTQpsqQRYINYFK
  .|   .. .. ..
akkq...wkalqeye
0051429 (Phosphotyrosine protein) phosphatases II 71-180 3.3e-12 42.2 In-house 50-217 (272) alignment 
Range on Protein: 71-180
Range on HMM: 50-217/272.0
YMIWNLSERV-------YdyskLNNQILEFPFLDHHPPPLSLLF------------------------------------------------EIVNSLSN
 .. ...||              . ..| .|.||...|. ....                                                | . .| .
vdLrseeErgrlkcdryw....pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallelle

WLKAdaENVAVVHCKGGKGRTGTIICCYLYYsCQFE---IMDD-------AKNHFAEKRSKMKKGVTQPSQQRYI
.| .  ..  .|||..||.||||.....| .  ...   |.||       . .  .| |... . |  . | ...
llld..ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfl
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 250-348 9.6e-12 36.2 Pfam-A 39-133 (134) alignment 
Range on Protein: 250-348
Range on HMM: 39-133/134.0
SnnnnnNNNNNNNNNNNQQQQLYKIIILIQKKVQNDVLIRVYRGDTGkgkGKMKKQIFHLIFNIAFVN--LDQCLFGMNEFDHFKSS--KKYDPNLQMEC
      ...............   . .  .  |..|||....  |.     ..|..||.. || .|.     .  .  || | .     ||...| ..| 
f.....kelasykdsterraktfivkepnrlpveGDvlveflhkdsk...lpkkekifrvwFNTsFieknqnvltlpkneLDkalkdkdkkfsknfkvel

RFQ
 |.
vfe
subfamily_PTPDC1_pd Subfamily PTPDC1 88-185 1.2e-11 39.4 In-house 83-173 (182) alignment 
Range on Protein: 88-185
Range on HMM: 83-173/182.0
NQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADaeNVAvVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFaekRSKMKKGVTQPSQQRYINYFKE
  . .|.. |.  ..|  ...||  ..  |. .  .|| |||  |.|||| .|.||| |. ...  ..| .     |||  | .   .| . .. |. 
iyvynfgwkDygvasleriLdivkvvafalqeg..kva.vhChaGlGrtGvliacylvyakrlt.aekaiklv...rskrpksiqtreqvelvkefal
DSPc Dual specificity phosphatase, catalytic domain 71-171 3.9e-10 34.7 Pfam-A 20-121 (133) alignment 
Range on Protein: 71-171
Range on HMM: 20-121/133.0
YMIWNLSERVYD---YSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVaVVHCKGGKGRTGTIICCYLYYSCQFeIMDDAKNHFAEKRSKM
 .. |....|     ..| ... |. |  |..   .|  .| . .  . .... ..| .|||. |  |..|.|..|| .. ..  ...| ... |.|||.
tlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrski

KKGV
 . .
spna
DSPc Dual specificity phosphatase, catalytic domain 71-171 3.9e-10 34.7 In-house 20-121 (133) alignment 
Range on Protein: 71-171
Range on HMM: 20-121/133.0
YMIWNLSERVYD---YSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVaVVHCKGGKGRTGTIICCYLYYSCQFeIMDDAKNHFAEKRSKM
 .. |....|     ..| ... |. |  |..   .|  .| . .  . .... ..| .|||. |  |..|.|..|| .. ..  ...| ... |.|||.
tlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrski

KKGV
 . .
spna
0048567 (Phosphotyrosine protein) phosphatases II 92-152 4e-09 31.0 In-house 42-107 (157) alignment 
Range on Protein: 92-152
Range on HMM: 42-107/157.0
EFPFLDHHPPPLSLLFEIVNSLSNWLK--ADAENVAVVHCKGGK---GRTGTIICCYLYYSCQFEI
| .| |. |..|..|.. .. | ..||    |... .|||| |    |||.|.|.||| . ..|  
edfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftp
subfamily_CDC14_pd Subfamily CDC14 66-151 8.4e-09 29.7 In-house 209-292 (328) alignment 
Range on Protein: 66-151
Range on HMM: 209-292/328.0
KHHGKYMIWNLSERVYDYSKLNNQILE---FPFLDHHPPPLSLLFEIVNSLSNWlkadaENVAVVHCKGGKGRTGTIICCYLYYSCQFE
....   .  | ...|| .| ... ..     | |   |. ... . .. . .      |  ..|||| | |||||.| ||| .  .| 
rknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrft
PTPc_DSPc_SM00012 98-180 9.8e-09 30.7 In-house 14-99 (105) alignment 
Range on Protein: 98-180
Range on HMM: 14-99/105.0
HHPPPLSLLFEIVNSLSNWLKADA-ENVAVVHCKGGKGRTGTIICCYLYYSCQFEI--MDDAKNHFAEKRSKMKKGVTQPSQQRYI
. | . . ..|..... .. .. . ..  ||||. | |||||... .. ..   .    .| .. . | |..  . |..  |. ..
gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl
subfamily_RNGTT_pd Subfamily RNGTT 110-166 2.1e-08 28.1 In-house 101-156 (189) alignment 
Range on Protein: 110-166
Range on HMM: 101-156/189.0
VNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEImDDAKNHFAEKRSK
 . .... |  .|.|  |||. |  ||| .|..||    .... ..| . ||. | .
iklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsv.eaavalFakaRpp
PTPc_motif_SM00404 66-169 6.8e-08 27.5 In-house 24-126 (140) alignment 
Range on Protein: 66-169
Range on HMM: 24-126/140.0
KHHGKYMIWNLSERVY-DYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVaVVHCKGGKGRTGTIICCYLYYSCQFEImDDAKNHFAEKR
| .|  .. |..| |  .... . |||. |  |..  .||  .. |..  .  ... ..| .|||. |  |..|.|..|| .. |... ..| . . |.|
kklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkv.lVHCqaGvSRSatliiaYlmryrqlsl.aeayefvkerR

SKMKK
.....
piisp
subfamily_DSP23_pd Subfamily DSP23 96-150 1.1e-07 26.6 In-house 60-112 (148) alignment 
Range on Protein: 96-150
Range on HMM: 60-112/148.0
LDHHPPPLSLLFEIVNSLSNwlkADAENVAV-VHCKGGKGRTGTIICCYLYYSCQF
 |.||| |  . |.|. . .   |.. | || |||  |.|||||.. |||    ..
ddyhppaleqvvefvrvvee...aeekneavsvhcllgrgrtgtmlacylvkerkl
subfamily_DSP11_pd Subfamily DSP11 55-165 2.3e-07 24.9 In-house 42-158 (178) alignment 
Range on Protein: 55-165
Range on HMM: 42-158/178.0
SIDDVCELLKQKHHGKYMIWNL--SERVYDYSKLNNQILEFPFL---DHHPPPLSLLFEIVNSLSNWL--KADAENVAVVHCKGGKGRTGTIICCYLYYS
. .|. | |..|..   .. .|   .| |. ..|... ...  |    |. |   |. .  . ....|  ..| ...  |||  |  ||| .|| ||   
tpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidv

CQFEiMDDAKNHFAEKRS
...|  .|| . | | | 
egye.pedaieafeearG
subfamily_CDKN3_pd Subfamily CDKN3 55-184 2.6e-07 24.4 In-house 70-192 (202) alignment 
Range on Protein: 55-184
Range on HMM: 70-192/202.0
SIDDVCELLKQKHHGKYMIWNLSErvyDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAEnvAVVHCKGGKGRTGTIICCYLYYSCQFEIMD
 ..||  |  .    || . .| .    |..    .  .|. |   |  .   .|.. |   |||  .  ..||| || ||.  .| | | |  ..  ..
gvedvfvlctrgelskyrvrrlld...lyqqaglivhhypiadglvpdiasclkileelrinlkayrk..tlvhcygglgrsslviaclllylddtiepk

DAKNHFAEKRSkmKKGVTQPSQQRYINYFK
|| ..  . .    . .    |  |.. |.
daidklrdlkg..sraiqtvkqynylsefr
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 55-147 1.8e-06 19.2 Pfam-A 71-158 (168) alignment 
Range on Protein: 55-147
Range on HMM: 71-158/168.0
SIDDVCELLKQKHHGKYMIWNLSERVYDYSKLnnqILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAEnvAVVHCKGGKGRTGTIICCYLYYS
 |.||  .  .    || . || .   .|  .       |  |   | ..  .||.. |.  ||   .  ...|| || ||.  . .| | | 
giqdvfvfctrgelskyrvpnlldlyqqygiv...thhhpiadggtpdiascleimeelatclknyrk..tlihcygglgrsclvaaclllyl
CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 55-147 1.8e-06 19.2 In-house 71-158 (168) alignment 
Range on Protein: 55-147
Range on HMM: 71-158/168.0
SIDDVCELLKQKHHGKYMIWNLSERVYDYSKLnnqILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAEnvAVVHCKGGKGRTGTIICCYLYYS
 |.||  .  .    || . || .   .|  .       |  |   | ..  .||.. |.  ||   .  ...|| || ||.  . .| | | 
giqdvfvfctrgelskyrvpnlldlyqqygiv...thhhpiadggtpdiascleimeelatclknyrk..tlihcygglgrsclvaaclllyl
subfamily_PRL_pd Subfamily PRL 56-146 4.7e-06 20.7 In-house 23-114 (151) alignment 
Range on Protein: 56-146
Range on HMM: 23-114/151.0
IDDVCELLKQKHhgKYMIWNLSERVYDYSKLNN---QILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYY
...  | ||...     .    |  || .||..   ..|...| |  .|| ... | .. | .  | .....  |||  | ||.  ...  |  
lekfieelkkee..vktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalie
subfamily_DSP8_pd Subfamily DSP8 75-186 9.6e-06 19.2 In-house 46-154 (159) alignment 
Range on Protein: 75-186
Range on HMM: 46-154/159.0
NLSERVYDYSKLN-NQILEFPFLDHHPPPLSLLFEIVNSLSNwlKADAENV-AVVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFAEKRSKMKKGVT
|.|.   . ..|. ...|  |  |..   |.  |.   .  .  || .||   .||.  |. |  |.. .|.    ... .|.| ..  |||  ... . 
nasnscpkleelkeskflrvPvkDkydekllpwfdksvefid..kaksengrvlvhvlaGisrsatvaiayimktlems.ldeayrfvkekrptispnln

QPSQqrYINYFKEI
   |   ..| ||.
flgq..Lleyekel