Gene cnrN in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP039_AA protein Get Run
DdisP039_AA_11-189 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTEN_pd Subfamily PTEN 9-189 2.3e-76 250.8 In-house 2-181 (184) alignment
Range on Protein: 9-189
Range on HMM: 2-181/184.0
IRSLVSADRHRFKSKemDLDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNL-SERVYDYSKLNNQILEFPFLDHHPPPLSLLF
.|..||....|||..  .|||||||||.||.|||.| ..||| .|||..||...|..||...|.|.|| ||| ||..|..... ..|| ||.||||.|| 
lrkivskkkkrfked..gldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelle

EIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRSKMKKGVTQPSQQRYINYFKEIVSG
|||.....||..| .||.||||| ||||||..|..||..|...| ...|...|||.|.|.||||| |||.||..|...... 
eivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekllee

subfamily_Tensin_pd Subfamily Tensin 24-193 2.7e-55 179.8 In-house 6-178 (189) alignment
Range on Protein: 24-193
Range on HMM: 6-178/189.0
EMDLDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAEN
|   ||||.|||. |.|. ||..|||...|... ||..|||.||. ||...||||. || ||||...|.| . |.. |.|  |  |..|| .||||| .|
eekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqn

VAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRS--KMKKGVTQPSQQRYINYFKEIVSGS-HMV
|.||||||||||.| .. .|. ||   .  | | ..|| ||   .  .|.|||||.||..||....||. .. 
vvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkikln

subfamily_VSP_pd Subfamily VSP 8-187 4.9e-50 164.4 In-house 15-198 (212) alignment
Range on Protein: 8-187
Range on HMM: 15-198/212.0
KIRSLVSADRHRFKSKEMdlDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNL-SERVYDYSKLNNQILEFPFLDHHPPPLSLL
 .| ||| .. |..   .  ||||.|.|. |.|| || .| .. .|| |..|. .|..||. .| . || ||| || . .||.. .    ||  | |. |
aarrlvsenkrrytqdGf..dldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleel

FEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRS-----KMKKGVTQPSQQRYINYFKEIV
. . . . .||..| .|| ..||||||||||||.|..| .| .||  ... ..|.|.|.     .. .||  |||.||..|.....
lvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvk

PTEN_1 14-188 1.8e-45 150.2 In-house 5-193 (196) alignment
Range on Protein: 14-188
Range on HMM: 5-193/196.0
SADRHRFKSKEMDLDLDLSYITDNILAMG-FPGTG-----LEASWRNSIDDVCELLKQKHHGK-YMIWNLSERV------YD---YSKLNNQILEFPFLD
| ..   .. . ...|||.|||. |.||| .|...      |  .|.|..|| ..|..... . ....||||.       ||   . | . . |.||. |
skrsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieD

HHPPPLSLLFEIVNSLSNWLKADA-ENVAVVHCKGGKGRTGTIICCYLYYSCQfEIMDDAKNHFAEKRSKMKKGvtQPSQQRYINYFKEIVS
|..|.|| ||.|..|. .||..|  .||..||||.|.||.||....|| |. .   .|.|  ...|||... .   .|||.|...||.|. .
hgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaella

subfamily_Auxilin_pd Subfamily Auxilin 28-188 9.3e-45 145.3 In-house 8-165 (166) alignment
Range on Protein: 28-188
Range on HMM: 8-165/166.0
DLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVV
|||.||||  |. | ||  |.| ...|.|||| . |  .|..||...|||.| |. .||.....|  .  .. |.|. |.|.   | .|||.| .|| ||
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvvv

HCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRSKMKkgvTQPSQQRYINYFKEIVS
||| |.  ...... .| .   ..  ..| . |. ||  .     .||..||..|. ....
hckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladlla

0036282 (Phosphotyrosine protein) phosphatases II 28-189 4.7e-41 135.7 In-house 9-171 (174) alignment
Range on Protein: 28-189
Range on HMM: 9-171/174.0
DLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLS-ERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAV
.|||||||....|...| . .|  ....| .|  ||. |. |.|...|.  |. .|...|. |.| .|. ||..|.|| |.|.|. . ..|. | ... .
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

VHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRSKMKKGVTQPSQQRYINYFKEIVSG
|||..|.|||||....|| . ...| ..|| ....|.|..  ..|. ||| |.. ||. ..||
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsg

0038934 (Phosphotyrosine protein) phosphatases II 33-183 5.9e-37 122.6 In-house 15-166 (194) alignment
Range on Protein: 33-183
Range on HMM: 15-166/194.0
YITDNILAMGFPGTG-----LEASWRNSIDDVCELLKQKHHGKYMIWNLS--ERVYDYSKLNN---QILEFPFLDH-HPPPLSLLFEIVNSLSNWLKADA
.||....|...| .|     .|  .|.|..|....||..... .....|.  ||.||.... .   ..|..|| |. ..|.|..|..... .  .|..|.
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

ENVAVVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFAEKRskmkkgvtqPSQQRYINYF
..| .||||.|.|||||....|| |....  ...| ..|.|||         |.. ....|.
ggvvaVHCkaGlgRtGtlvaaYLiyrlgms.aeeAialfrekR.........pgaipnqdyl

0046846 (Phosphotyrosine protein) phosphatases II 25-185 1.8e-33 111.1 In-house 6-170 (176) alignment
Range on Protein: 25-185
Range on HMM: 6-170/176.0
MDLDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQkhhGKYMIWNLSERV-----------YDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSL
. |||||.||..|......|... .  .|.  |.. .|...   | ... || |.|            .. ||. |.| .|. ||..|.|.||.|... .
lgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefi

SNWLKADaeNVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDDAKNHFAEKRSKmkKGVTQPSQQRYINYFKE
 ..||..  .. .|||..|.|||||....|| .. ..  ...|  .. |.|..  . |. |.| |.. .|  
realkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefel

0041856 (Phosphotyrosine protein) phosphatases II 25-183 1e-30 102.1 In-house 13-166 (182) alignment
Range on Protein: 25-183
Range on HMM: 13-166/182.0
MDLDLDLSYITDNILAMGFPGTGLEASWRNSIDDVCELLKQKHHGKY-MIWNLSERVYDYSKLNN---QILEFPFLDHHPPPLSLLFEIVNSLSNwlkad
.| ..||.||..|......|.|  .| ... ...| . |.. .. .. .|.||.|. |....|..   |.| .|. ||..|.|. |.....   .     
ydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....

AENVAVVHCKGGKGRTGTIICCYLYYSCQFEIMDdAKNHFAEKRSKmkkGVTQPSQQRYINYF
 ... .|||..|.|||||....|| ..... . . | ... ..|..   .|..|.| ... ..
eggpvlVHCsaGvgRtgtlvaaylmkklgvslee.avklvrsrRpg...mvitpnqyfflqla

0037934 (Phosphotyrosine protein) phosphatases II 24-183 1.8e-30 101.7 In-house 32-237 (243) alignment
Range on Protein: 24-183
Range on HMM: 32-237/243.0
EMDLDLDLSYITDNILAMGFPGTGLEAS---------WRNSIDDVC----------------------------ELLKQKHHGKYMIWNLSERV---YDY
.  ....|.|.|... |...| ..  ..         |.. |. ..                            .||...|...|....|. .    .|.
sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

SKLNNQILEFPFLDHHPPP-LSLLFEIVNSLSNWLKA-------DAENVAVVHCKGGKGRTGTIICCYLYYSC-QfEIMDDAKNHFAEKRSKmkKGVTQP
..|. ... .|. ||..|.  . | .... . .....       | ... .|||..|.|||||.|..|| ... .   ...| ... |.|.   |.|. |
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg.vdleeavkllreqRpg..kavqtp

SQQRYINYF
|| |.. ..
sqyrflyea

0043147 (Phosphotyrosine protein) phosphatases II 28-185 8.4e-30 99.1 In-house 12-158 (172) alignment
Range on Protein: 28-185
Range on HMM: 12-158/172.0
DLDLSYITDNILAMGFPgtgleasWRNSIDDVCELLKQKHHGKymIWNLSER---VYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENV
.|||.||.|...|. .|       .|| ..|. ..||... .   |.|| |.    .....|. |.| .|. ||..|.|.|| |... . ..|  . ...
yldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggp

AVVHCKGGKGRTGTIICCYLYYsCQFeIMDDAKNHFAEKRskmKKGVTQPSQQRYINYFKE
 .|||..|.|||||....|| . ...  ...| ... |||    ..|. |||.|.. || .
vlVHCsaGvgRtgtlvaaylml.lgl.sleeavalvrekR...pgavqnpsqyrflyyfek

0039614 (Phosphotyrosine protein) phosphatases II 14-183 4.4e-29 97.3 In-house 56-284 (297) alignment
Range on Protein: 14-183
Range on HMM: 56-284/297.0
SADRHRFK------------SKEMDLDLDLSYI-----------TDNILAMGFPGTG-----LEASWRNSIDDVC-------------------------
. |..|.|            . |.. |||..||           |....|...| ..     ..  |.. .  .                          
nkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygd

---ELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPFLDHHPPP-LSLLFEIVNSLSNWLKAD-AENVAVVHCKGGKGRTGTIICCYLY-----YSCQF
   .||| .|.. |....|. . ...|.  .... ... ||..|| |.||.|... . ..|...  ... .|||..|.|||||.|..||      . ...
ftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

EiMDDAKNHFAEKRskmKKGVTQPSQQRYINYF
  ...| ... |.|    ..|. ||| |.. ..
d.vleavkelreqR...pgavqtpsqyrflyda

0042113 (Phosphotyrosine protein) phosphatases II 12-183 1.7e-27 91.8 In-house 18-238 (245) alignment
Range on Protein: 12-183
Range on HMM: 18-238/245.0
LVSADRHRFKSKEMDLDLDLSYI----------TDNILAMGFPGTGLEA-----SWRNSIDDVC------------------------------ELLKQK
 .  |. |.| .... |||..||          |....|...| ..  .      |.. |  ..                              .||. .
ilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllsee

HHGKYMIWNLSER--VYDYSKLNNQILEFPFLDHHPPP-LSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLY-----YSCQFEiMDDAKN
|...|....|.     .|.|. ..... .|. ||..|. |.||..... . ..|..|.... .|||..|.|||||.|..||      . . .  ...|  
hlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs.leeavk

HFAEKRskmKKGVTQPSQQRYINYF
.. ..|    . |. ||| |.. ..
elrsqR...pgavqtpsqyrflyea

0049260 (Phosphotyrosine protein) phosphatases II 40-186 3.4e-27 90.4 In-house 6-148 (152) alignment
Range on Protein: 40-186
Range on HMM: 6-148/152.0
AMGFPGTGLEASWRNSIDDVCELLKQKHHGKY-MIWNLSERVYDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGT
||.|. .. .. ..|...|. ..||. . . . |...|.|. ... .   |.| .|. ||..|.|| |..... . ..|. | ... .|||..|.|||||
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

IICCYLYYscqfeIMDDAKNHFAEKRSKMKKGVTQPSQQRYINYFKEI
....|| .        .... .|  |.| ...|. |.| |.. .| ..
lvaaylml.....lgvsleeavalvrekRpgavpnpgqlrflyefekl

0043336 (Phosphotyrosine protein) phosphatases II 12-183 1.2e-26 89.2 In-house 54-272 (278) alignment
Range on Protein: 12-183
Range on HMM: 54-272/278.0
LVSADRHRFKSKEMDLDLDLSYI----------TDNILAMGFPGTGLEASWRNSIDD----------------------------------VCELLKQKH
 .  |..| | . .. |||..||          .....|...| .. .. ... . .                                  . .|||..|
ilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeeh

HGKYMIWNLSER--VYDYSKLNNQILEFPFLDHHPP-PLSLLFEIVNSLSNWLKaDAENVAVVHCKGGKGRTGTIICCYLYY-SCQFEIMDDAKNHFAEK
.. |....|      ...|.  ...  ... ||. | .||||..... . ..|. | ... .|||..|.|||||.|..|| .   . |   |. . ..| 
lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkel

RSKMKKGVTQPSQQRYINYF
|..  . |. ||| |.. ..
reqRpgavqtpsqyrflyea

0051082 (Phosphotyrosine protein) phosphatases II 29-183 4e-26 86.8 In-house 6-147 (151) alignment
Range on Protein: 29-183
Range on HMM: 6-147/151.0
LDLSYITDNILAMGFPgtgLEaswrnsidDVCELLkqKHHGKYMIWNLSERV---YDYSKLNN---QILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAE
...||.|......|.|   |.        |. |||  |..| ..| || . .   |... |..   ..| .|.||...|.|.|.|..|... ..| .. .
infsyvtgglyrsggp...la........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVAVVHCKGGKGRTGTIICCYLYYscQFEIMDDAKNHFAEKRSkmkkGVTQPSQQRYINYF
.. .|||..|||||||....|| .  .   ...| ... .||     ||.||.||... .|
gpvlvHCsaGkgRTGtlvalylml..lgvsleealeeyrlkrp....gvvqpnqqflfqlf

0048076 (Phosphotyrosine protein) phosphatases II 44-184 1.2e-25 85.3 In-house 4-139 (145) alignment
Range on Protein: 44-184
Range on HMM: 4-139/145.0
PGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPFLDHHPPPL-SLLFEIVNSLSNWLKADaeNVAVVHCKGGKGRTGTIICC
|   |.  ...|. ....|   |..| ....||.   .....|. |.| .|. ||..|.| .|| |... . ..||..  .. .|||. |.|||||....
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaa

YLYYSCQFEiMDDAKNHFAEKRSKmkkGVTQPSQQRYINYFK
|| .....  ...| ... ..|..   .|. |.|.|.. .| 
ylmlllgvs.leealelvrsqrpg...avpnpgqlrflyefe

0044763 (Phosphotyrosine protein) phosphatases II 26-185 7.1e-25 83.1 In-house 18-168 (178) alignment
Range on Protein: 26-185
Range on HMM: 18-168/178.0
DLDLDLSYITDNILAMGFPGTG-LEASWRNSIDDVCELLKQKHHGkymiwNLSERVYDYSKLNNQILEFPFLDHHPPP-LSLLFEIVNSLSNWLKADAeN
   ...|.|.........|    ||  ... |. .. | . ...|      |..  |.... . | | .|. ||..|. |. ..|.|. . ..|. .  .
sdyinaseilpglylgslppaddlellkelgithivnlteelelg.....flkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg.g

VAVVHCKGGKGRTGTIICCYLYYSCQFeIMDDAKNHFAEKRskmKkGVTQPSQQRYINYFKE
. .|||. |.||.||....|| .....  ...| ... |.|     .|. |.|.|.. .| .
pvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR...p.ivpnpgqlrqLyefel

0048179 (Phosphotyrosine protein) phosphatases II 44-185 9.3e-25 82.4 In-house 4-142 (144) alignment
Range on Protein: 44-185
Range on HMM: 4-142/144.0
PGTGLEASWRNSIDDVCELLKQKHHGKYMIWNLSERVYDYSKLNN--QILEFPFLDHHPPPL-SLLFEIVNSLSNWLKADaeNVAVVHCKGGKGRTGTII
|   |.  ...|. ....|   |..| ....||.|  . ..  ..  |.| .|. ||..|.| .|| |... . ..|. .  .. .|||..|.|||||..
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlv

CCYLYYSCQFEiMDDAKNHFAEKRSkmkKGVTQPSQQRYINYFKE
..|| . ...  ...| ... ..|.    .|. |.| |.. .. .
aaylmkklgls.leealalvrsrrp...gavpnpgqlrfLleyek

0045098 (Phosphotyrosine protein) phosphatases II 24-183 9.7e-23 76.4 In-house 2-267 (278) alignment
Range on Protein: 24-183
Range on HMM: 2-267/278.0
EMDLDLDLSYITDNILAMGFPGTGLEASWRNSID------------------------------------------------------------------
| . .|||.......|..|.|.. ..| .....|                                                                  
ealasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-------------------------DVCELlKQKHHGKYMIWNLSERVYDYSKLNNQILEF-PFLDHHPPPLS---LLFEIVNSLSNWLK----------
                         ....| .  .. .....||. . .|. ... ..| . |. ||..|.|.    ..|... . ..||          
grekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

--ADAENVAVVHCKGGKGRTGTIICCYLYYSC---QFEiMDDAKNHFAEKRskmKK-GVTQPSQQRYINYF
   | ... .|||. |.|||||....|| ...   ..  ...| ... ..|       |. ..|.|.. .|
llldsggpvlVHCsaGvgRtGtlvaaylmlelleggvd.lleavkelrsqR...pglavqnleqyrflyef

0045450 (Phosphotyrosine protein) phosphatases II 31-183 1.9e-21 72.5 In-house 107-299 (307) alignment
Range on Protein: 31-183
Range on HMM: 107-299/307.0
LSYI----------------------------------TDNILAMGFPGTGLEASWRNsidDVCELLKQKHHGKYMIWNLSERVYDYSKLNNQILEFPF-
. .|                                  .... |. .| .| |  ..|   .. .||. .|...| ...|    .|...   ..  |.. 
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhyt

--LDHHPPP-LSLLFEIVNSLSNWLKAD-AENVAVVHCKGGKGRTGTIICCYLYYSCQ--------FEiMDDAKNHFAEKRskmKKGVTQPSQQRYINYF
   ||. || .. |..... . ..|...  ... .|||..|.|||||.|..|| ...         .  ...| ... |.|    ..|. |.| |.. ..
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd.lleavkllreqR...pgavqnpeqyrflyea





0049772 (Phosphotyrosine protein) phosphatases II 44-184 1.5e-20 69.6 In-house 155-274 (314) alignment
Range on Protein: 44-184
Range on HMM: 155-274/314.0
PgtgleaswrnSIDDVCELLKQKhhgkymiwnlsERV---YDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWlkaDAENVAVVHCKGGKGRTGT-I
.          .. ....|   |           |..    ....|. . | .|. |...|.|. . |... . ..   |.... .||||.||||||| .
g..........neptaadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfv

ICCYLYYSCQFeIMDDAKNHFAEKRSKMKKGVTQPSQQRYINYFK
...|| . ...  ...| ... .||.   . .. .....|.....
vaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefile

0040438 (Phosphotyrosine protein) phosphatases II 14-183 1.9e-20 68.8 In-house 54-271 (317) alignment
Range on Protein: 14-183
Range on HMM: 54-271/317.0
SADRHRFKSKEMDLDLDLSYI----------TDNILAMGFPGtgleaswRNSIDDVCELLKQ------------K-----------------HHGKYMIW
  |. | | . .. |||..||          .....|...|         |...|  .....            .                 ..|.....
pydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.......pntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvt

NLSERVydysKLNNQILEFPF-------------------LDHHPPP-LSLLFEIVNSLSNWLKaDAENVAVVHCKGGKGRTGTIICCYLY-----YSCQ
.||| .    . . .......                    ||..|| ..||..... . ..|. | ... .|||..|.|||||.|..||      . ..
llseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekegg

FEiMDDAKNHFAEKRskmKKGVTQPSQQRYINYF
.  ...| ... |.|    ..|. |.| |.. ..
vd.veeavkelreqR...pgavqtpeqyrflyda

0040439 (Phosphotyrosine protein) phosphatases II 29-183 5.9e-20 67.4 In-house 47-241 (249) alignment
Range on Protein: 29-183
Range on HMM: 47-241/249.0
LDLSYITDNILAMGFPGTGLEASWRNSIDD-----------------------------------VCELLKQKHHGKYMIWNLSER--VYDYSKLNNQIL
.|..||.....|...| ..  ..... . .                                   . .||. .....|....|      .. |   ..| 
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

EFPFLDHHPP-PLSLLFEIVNSLSNWLKAD-AENVAVVHCKGGKGRTGTIICCYLY-----YSCQFEimddAKNHFAEKRSKMKKGVTQPSQQRYINYF
 ... ||. |  .. |..... . ..|...  ... .|||..|.|||||.|..||      . ...     ... ... ||.  ..|. |.| |.. ..
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd....leeavkllrsqRpgavqnpeqyrflyea

0046845 (Phosphotyrosine protein) phosphatases II 28-183 2.8e-19 65.0 In-house 69-269 (284) alignment
Range on Protein: 28-183
Range on HMM: 69-269/284.0
DLDLSYITDNILAMGFPGTG-----------------------------LEASWRNSIDDVCEL-------LKQKHHGKYMIWNLSERVYDYSKLNNQIL
||||.||. ...|. .|  .                               | .......| ..       |. .... |....|. . ..|..   .. 
dldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvt

EFPFL---DHHPPP-LSLLFEIVNSLSNWLKA-DAENVAVVHCKGGKGRTGTIICCYLYYSCQ-FEI---MDDAKNHFAEKRSKMKKGVTQPSQQRYINY
 | ..   ||. || .. |.|... . ..|.. . ... ||||..|.|||||.|...| ...   |    . |. . ..  |..    |....| |.. .
hfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvye

F
.
a

0047943 (Phosphotyrosine protein) phosphatases II 60-182 3.7e-19 64.7 In-house 139-266 (273) alignment
Range on Protein: 60-182
Range on HMM: 139-266/273.0
CELLKQKHHGKYMIWNLSERV--YDYSKLNNQILEFPFLDHHPP-PLSLLFEIVNSLSNWLKAD-AENVAVVHCKGGKGRTGTIICCYLYYSCQ-FEIMD
 .||...... |....|  .   ...|.  .... ... ||. |  |. |.|... . ..|.|.  ... ||||..|.|||||.|...| ...   | . 
vtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggv

DAKNHFAEKRSKMKKGVTQPSQQRYINY
|... ..  ||.   .|. |.| |.. .
dvleavkllrsqRpgmvqtpeqyrflye

0051299 (Phosphotyrosine protein) phosphatases II 61-181 1.2e-17 59.8 In-house 152-279 (288) alignment
Range on Protein: 61-181
Range on HMM: 152-279/288.0
ELLKQKHHGKYMIWNLSERVYD---YSKLNNQILEFPFL---DHHPPP-LSLLFEIVNSLSNWLKaDAENVAVVHCKGGKGRTGTIICCYLYYSC-QFEI
.||. .....|....|  . .|   ...   ..  | ..   ||. |. ..||..... . ..|. . ... ||||. |.|||||.|...| ... ..| 
tllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeg

MDDAKNHFAEKRSKMKKGVTQPSQQRYIN
. |. . ..  |..    |. |.| |.. 
gvdvleavkrlreqRpgmvqtpeqyrfvy

0050432 (Phosphotyrosine protein) phosphatases II 65-180 1.6e-14 49.4 In-house 162-291 (308) alignment
Range on Protein: 65-180
Range on HMM: 162-291/308.0
QKHHGKYMIWNLSERVYDYSKLNNQILEF-----------------PflDHHPPP-LSLLFEIVNSLSNWLkadAENVAVVHCKGGKGRTGTIICCYLYY
 ...||. . .||| |.|. .. . .|..                 |  ||. || .. |..... . ..|    ... ||||. | |||||.|...| .
sleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp..dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdlll

SCQ-FEIMDDAKNHFAEKRSKMKKGVTQPSQQRYI
..   | . |. . ..  |..    |. |.| ...
eqlekeggvdvfeavkklReqRpgmvqtpeqylfl

0036941 (Phosphotyrosine protein) phosphatases II 65-183 2.5e-14 48.7 In-house 131-272 (297) alignment
Range on Protein: 65-183
Range on HMM: 131-272/297.0
QKHHGKYMIWNLSERV-----------------YDYSKLNNQILEFPFLDHHPPP-LSLLFEIVNSLSNWLKAD-AENVAVVHCKGGKGRTGTIICCYLY
 . .|......||. |                 ...|.  ...  .   ||..|.  . |..... . ..||.   ... .|||..|.||.||.|...| 
sltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlm

--------YSCQFEimddAKNHFAEKRSKMKKGVTQPSQQRYINYF
        . ...      .. . . |..    |....| |.. ..
lqqledklkeggvd....ileavkklReqRpgavqtleqyrflyea

subfamily_PTPMT1_pd Subfamily PTPMT1 71-184 1e-12 42.8 In-house 57-165 (171) alignment
Range on Protein: 71-184
Range on HMM: 57-165/171.0
YMIWNLSERVYDYSKLNNQILEFPFLDHH-PPPLSLLFEIVNSLSNWLKadAENVAVVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFAEKRSKMKK
| .  |.. . ...||. ..|...  |.   | |  |.. |. ...  .    .   ||||.|.||..|.. ||| .. ... ...| .. ..||.....
yelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvas..kgkrvYvHCkaGrgRsatlvacylmkkekls.peeAlkalkkkRkiirl

GVTQpsqQRYINYFK
  .|   .. .. ..
akkq...wkalqeye

0051429 (Phosphotyrosine protein) phosphatases II 71-180 3.3e-12 42.2 In-house 50-217 (272) alignment
Range on Protein: 71-180
Range on HMM: 50-217/272.0
YMIWNLSERV-------YdyskLNNQILEFPFLDHHPPPLSLLF------------------------------------------------EIVNSLSN
 .. ...||              . ..| .|.||...|. ....                                                | . .| .
vdLrseeErgrlkcdryw....pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallelle

WLKAdaENVAVVHCKGGKGRTGTIICCYLYYsCQFE---IMDD-------AKNHFAEKRSKMKKGVTQPSQQRYI
.| .  ..  .|||..||.||||.....| .  ...   |.||       . .  .| |... . |  . | ...
llld..ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfl

PTEN_C2 C2 domain of PTEN tumour-suppressor protein 250-348 9.6e-12 36.2 Pfam-A 39-133 (134) alignment
Range on Protein: 250-348
Range on HMM: 39-133/134.0
SnnnnnNNNNNNNNNNNQQQQLYKIIILIQKKVQNDVLIRVYRGDTGkgkGKMKKQIFHLIFNIAFVN--LDQCLFGMNEFDHFKSS--KKYDPNLQMEC
      ...............   . .  .  |..|||....  |.     ..|..||.. || .|.     .  .  || | .     ||...| ..| 
f.....kelasykdsterraktfivkepnrlpveGDvlveflhkdsk...lpkkekifrvwFNTsFieknqnvltlpkneLDkalkdkdkkfsknfkvel

RFQ
 |.
vfe

subfamily_PTPDC1_pd Subfamily PTPDC1 88-185 1.2e-11 39.4 In-house 83-173 (182) alignment
Range on Protein: 88-185
Range on HMM: 83-173/182.0
NQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADaeNVAvVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFaekRSKMKKGVTQPSQQRYINYFKE
  . .|.. |.  ..|  ...||  ..  |. .  .|| |||  |.|||| .|.||| |. ...  ..| .     |||  | .   .| . .. |. 
iyvynfgwkDygvasleriLdivkvvafalqeg..kva.vhChaGlGrtGvliacylvyakrlt.aekaiklv...rskrpksiqtreqvelvkefal

DSPc Dual specificity phosphatase, catalytic domain 71-171 3.9e-10 34.7 Pfam-A 20-121 (133) alignment
Range on Protein: 71-171
Range on HMM: 20-121/133.0
YMIWNLSERVYD---YSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVaVVHCKGGKGRTGTIICCYLYYSCQFeIMDDAKNHFAEKRSKM
 .. |....|     ..| ... |. |  |..   .|  .| . .  . .... ..| .|||. |  |..|.|..|| .. ..  ...| ... |.|||.
tlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrski

KKGV
 . .
spna

DSPc Dual specificity phosphatase, catalytic domain 71-171 3.9e-10 34.7 In-house 20-121 (133) alignment
Range on Protein: 71-171
Range on HMM: 20-121/133.0
YMIWNLSERVYD---YSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVaVVHCKGGKGRTGTIICCYLYYSCQFeIMDDAKNHFAEKRSKM
 .. |....|     ..| ... |. |  |..   .|  .| . .  . .... ..| .|||. |  |..|.|..|| .. ..  ...| ... |.|||.
tlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkv.lVHCqaGisRSatliiaYlmktknl.slneAyefvkerrski

KKGV
 . .
spna

0048567 (Phosphotyrosine protein) phosphatases II 92-152 4e-09 31.0 In-house 42-107 (157) alignment
Range on Protein: 92-152
Range on HMM: 42-107/157.0
EFPFLDHHPPPLSLLFEIVNSLSNWLK--ADAENVAVVHCKGGK---GRTGTIICCYLYYSCQFEI
| .| |. |..|..|.. .. | ..||    |... .|||| |    |||.|.|.||| . ..|  
edfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftp

subfamily_CDC14_pd Subfamily CDC14 66-151 8.4e-09 29.7 In-house 209-292 (328) alignment
Range on Protein: 66-151
Range on HMM: 209-292/328.0
KHHGKYMIWNLSERVYDYSKLNNQILE---FPFLDHHPPPLSLLFEIVNSLSNWlkadaENVAVVHCKGGKGRTGTIICCYLYYSCQFE
....   .  | ...|| .| ... ..     | |   |. ... . .. . .      |  ..|||| | |||||.| ||| .  .| 
rknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrft

PTPc_DSPc_SM00012 98-180 9.8e-09 30.7 In-house 14-99 (105) alignment
Range on Protein: 98-180
Range on HMM: 14-99/105.0
HHPPPLSLLFEIVNSLSNWLKADA-ENVAVVHCKGGKGRTGTIICCYLYYSCQFEI--MDDAKNHFAEKRSKMKKGVTQPSQQRYI
. | . . ..|..... .. .. . ..  ||||. | |||||... .. ..   .    .| .. . | |..  . |..  |. ..
gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

subfamily_RNGTT_pd Subfamily RNGTT 110-166 2.1e-08 28.1 In-house 101-156 (189) alignment
Range on Protein: 110-166
Range on HMM: 101-156/189.0
VNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYYSCQFEImDDAKNHFAEKRSK
 . .... |  .|.|  |||. |  ||| .|..||    .... ..| . ||. | .
iklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsv.eaavalFakaRpp

PTPc_motif_SM00404 66-169 6.8e-08 27.5 In-house 24-126 (140) alignment
Range on Protein: 66-169
Range on HMM: 24-126/140.0
KHHGKYMIWNLSERVY-DYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVaVVHCKGGKGRTGTIICCYLYYSCQFEImDDAKNHFAEKR
| .|  .. |..| |  .... . |||. |  |..  .||  .. |..  .  ... ..| .|||. |  |..|.|..|| .. |... ..| . . |.|
kklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkv.lVHCqaGvSRSatliiaYlmryrqlsl.aeayefvkerR

SKMKK
.....
piisp

subfamily_DSP23_pd Subfamily DSP23 96-150 1.1e-07 26.6 In-house 60-112 (148) alignment
Range on Protein: 96-150
Range on HMM: 60-112/148.0
LDHHPPPLSLLFEIVNSLSNwlkADAENVAV-VHCKGGKGRTGTIICCYLYYSCQF
 |.||| |  . |.|. . .   |.. | || |||  |.|||||.. |||    ..
ddyhppaleqvvefvrvvee...aeekneavsvhcllgrgrtgtmlacylvkerkl

subfamily_DSP11_pd Subfamily DSP11 55-165 2.3e-07 24.9 In-house 42-158 (178) alignment
Range on Protein: 55-165
Range on HMM: 42-158/178.0
SIDDVCELLKQKHHGKYMIWNL--SERVYDYSKLNNQILEFPFL---DHHPPPLSLLFEIVNSLSNWL--KADAENVAVVHCKGGKGRTGTIICCYLYYS
. .|. | |..|..   .. .|   .| |. ..|... ...  |    |. |   |. .  . ....|  ..| ...  |||  |  ||| .|| ||   
tpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidv

CQFEiMDDAKNHFAEKRS
...|  .|| . | | | 
egye.pedaieafeearG

subfamily_CDKN3_pd Subfamily CDKN3 55-184 2.6e-07 24.4 In-house 70-192 (202) alignment
Range on Protein: 55-184
Range on HMM: 70-192/202.0
SIDDVCELLKQKHHGKYMIWNLSErvyDYSKLNNQILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAEnvAVVHCKGGKGRTGTIICCYLYYSCQFEIMD
 ..||  |  .    || . .| .    |..    .  .|. |   |  .   .|.. |   |||  .  ..||| || ||.  .| | | |  ..  ..
gvedvfvlctrgelskyrvrrlld...lyqqaglivhhypiadglvpdiasclkileelrinlkayrk..tlvhcygglgrsslviaclllylddtiepk

DAKNHFAEKRSkmKKGVTQPSQQRYINYFK
|| ..  . .    . .    |  |.. |.
daidklrdlkg..sraiqtvkqynylsefr

CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 55-147 1.8e-06 19.2 Pfam-A 71-158 (168) alignment
Range on Protein: 55-147
Range on HMM: 71-158/168.0
SIDDVCELLKQKHHGKYMIWNLSERVYDYSKLnnqILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAEnvAVVHCKGGKGRTGTIICCYLYYS
 |.||  .  .    || . || .   .|  .       |  |   | ..  .||.. |.  ||   .  ...|| || ||.  . .| | | 
giqdvfvfctrgelskyrvpnlldlyqqygiv...thhhpiadggtpdiascleimeelatclknyrk..tlihcygglgrsclvaaclllyl

CDKN3 Cyclin-dependent kinase inhibitor 3 (CDKN3) 55-147 1.8e-06 19.2 In-house 71-158 (168) alignment
Range on Protein: 55-147
Range on HMM: 71-158/168.0
SIDDVCELLKQKHHGKYMIWNLSERVYDYSKLnnqILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAEnvAVVHCKGGKGRTGTIICCYLYYS
 |.||  .  .    || . || .   .|  .       |  |   | ..  .||.. |.  ||   .  ...|| || ||.  . .| | | 
giqdvfvfctrgelskyrvpnlldlyqqygiv...thhhpiadggtpdiascleimeelatclknyrk..tlihcygglgrsclvaaclllyl

subfamily_PRL_pd Subfamily PRL 56-146 4.7e-06 20.7 In-house 23-114 (151) alignment
Range on Protein: 56-146
Range on HMM: 23-114/151.0
IDDVCELLKQKHhgKYMIWNLSERVYDYSKLNN---QILEFPFLDHHPPPLSLLFEIVNSLSNWLKADAENVAVVHCKGGKGRTGTIICCYLYY
...  | ||...     .    |  || .||..   ..|...| |  .|| ... | .. | .  | .....  |||  | ||.  ...  |  
lekfieelkkee..vktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalie

subfamily_DSP8_pd Subfamily DSP8 75-186 9.6e-06 19.2 In-house 46-154 (159) alignment
Range on Protein: 75-186
Range on HMM: 46-154/159.0
NLSERVYDYSKLN-NQILEFPFLDHHPPPLSLLFEIVNSLSNwlKADAENV-AVVHCKGGKGRTGTIICCYLYYSCQFEiMDDAKNHFAEKRSKMKKGVT
|.|.   . ..|. ...|  |  |..   |.  |.   .  .  || .||   .||.  |. |  |.. .|.    ... .|.| ..  |||  ... . 
nasnscpkleelkeskflrvPvkDkydekllpwfdksvefid..kaksengrvlvhvlaGisrsatvaiayimktlems.ldeayrfvkekrptispnln

QPSQqrYINYFKEI
   |   ..| ||.
flgq..Lleyekel