Gene DDB_G0289979 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP042_AA protein Get Run
DdisP042_AA_8-194 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTEN_pd Subfamily PTEN 9-186 1.5e-71 235.2 In-house 2-179 (184) alignment 
Range on Protein: 9-186
Range on HMM: 2-179/184.0
VRKTISADKNRYENEEYDLDLTYITERVIAMSFPADGVESAYRNSIYDVSKLLNTSHKDHYLIYNL-SERKYDYSLFNGMVLDWcGFPDHHAPPLGLLFK
.||..|..|.|......||||.||||..|||..||...|..||||. || |.|...||||| |||| ||||||.. |.|.|  . .| ||..||| || .
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavy.pfdDhnppplellee

IVMTIYSWLEKDPMNVVVVHCMAGKGRTGTVISALLQYGGLFEGASDAMRYFAVKRSNNNYGITGPSQIRYTQYFSDIY
|| .| .|||.|. |||||||.|||||||..|.|.| . .|.| |..|...|| .|..|. |.| |||.|| .|.....
ivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekll
subfamily_Tensin_pd Subfamily Tensin 17-201 1.7e-58 190.3 In-house 1-186 (189) alignment 
Range on Protein: 17-201
Range on HMM: 1-186/189.0
KNRYENEEYDLDLTYITERVIAMSFPADGVESAYRNSIYDVSKLLNTSHKDHYLIYNLSERKYDYSLFNGMVLDWcGFPDHHAPPLGLLFKIVMTIYSWL
|.|| .|..||||||||||.||.||||.|.|..||... ||.|||.. |.|.||..||||..|| | .|  |||  |.||..||.|  |  |. .. |||
kvryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldf.GWPdllaPsleklcsicksldsWl

EKDPMNVVVVHCMAGKGRTGTVISALLQYGGLFEGASDAMRYFAVKRSNNN--YGITGPSQIRYTQYFSDIYFGGKELNPGPVFLKS
..|| |||||||  ||||.| |.|| ..|  . ..|. |.  ||.||  ..   |.| ||| || .|||..  |  .||  |.||. 
kadpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhy
subfamily_VSP_pd Subfamily VSP 4-187 1.7e-57 188.8 In-house 11-199 (212) alignment 
Range on Protein: 4-187
Range on HMM: 11-199/212.0
SIVKAVRKTISADKNRYENEEYDLDLTYITERVIAMSFPADGVESAYRNSIYDVSKLLNTSHKDHYLIYNL-SERKYDYSLFNGMVLDwCGFPDHHAPPL
 . ||.|. .| .| ||... .||||||.|||.||||||. | .| ||| | .|...|.| |.||| ..|| |||.|| . ||  |   .   ||  | |
klekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkr.iliddhnvpkl

GLLFKIVMTIYSWLEKDPMNVVVVHCMAGKGRTGTVISALLQYGGLFEGASDAMRYFAVKRSNNN-----YGITGPSQIRYTQYFSDIYF
  |...  ..  |||||. ||...||  |||||||.. ||| . ..|| | ... ||...|....      |.  ||| || .|. .. .
eellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvkt
subfamily_Auxilin_pd Subfamily Auxilin 25-185 7e-52 168.5 In-house 7-163 (166) alignment 
Range on Protein: 25-185
Range on HMM: 7-163/166.0
YDLDLTYITERVIAMSFPADGVESAYRNSIYDVSKLLNTSHKDHYLIYNLSERKYDYSLFNGMVLDwCGFPDHHAPPLGLLFKIVMTIYSWLEKDPMNVV
 |||..||| |.| |||||.||||.|.|.| ||.. |.. |...||.||||.|.|. . ... |.. .|.| ..||.|  |...   .||||.||| |||
ndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvve.agwparraPnLeslvevcrnlyswlkkdpknvv

VVHCMAGKGRTGTVISALLQYGGLFEGASDAMRYFAVKRSNNNygiTGPSQIRYTQYFSDI
||||. |.  .....|||| .  |.. ...|.| |.|||   .     ||. || .|..|.
vvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladl
PTEN_1 11-184 7e-43 141.7 In-house 4-190 (196) alignment 
Range on Protein: 11-184
Range on HMM: 4-190/196.0
KTISADKNRYENEEYDLDLTYITERVIAMS-FPADG-----VESAYRNSIYDVSKLLNTSHKDH-YLIYNLSERK------YDYSLFNGMVLD--WCGFP
.... .|... ... .|||||||.|.|||. .|...      |. ||.|. ||...|.. ..|. .|..||||..      || ..|. . .    ....
lskrsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpie

DHHAPPLGLLFKIVMTIYSWLEKDP-MNVVVVHCMAGKGRTGTVISALLQYGGLfEGASDAMRYFAVKRSNNNYGitGPSQIRYTQYFSD
||.||.|  ||.|.  . .|| .||  |||.||| ||.||.|||. |.| | |    | .|..... ||....     ||| |. .||..
DhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfae
0036282 (Phosphotyrosine protein) phosphatases II 26-185 4.4e-39 129.3 In-house 9-168 (174) alignment 
Range on Protein: 26-185
Range on HMM: 9-168/174.0
DLDLTYITERVIAMSFPADGVESAYRNSIYDVSKLLNTSHKDHYLIYNLSERKYDYSLFNGMVLDWCGFPDHHAPPLGLLFKIVMTIYSWLEKDPMNVVV
.|||.|||.|.||...|.. .|  ....| .|  ||.  ....|...|.  .....   .|. . ....|||..|.|  |...|  ....|..|| ..|.
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

VHCMAGKGRTGTVISALLQYGGLFEGASDAMRYFAVKRSNNNYGITGPSQIRYTQYFSDI
|||.||.|||||.. |.| . ||.|.. ||..... .|. . .... |||.|. .||...
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0038934 (Phosphotyrosine protein) phosphatases II 30-194 1.5e-34 114.7 In-house 14-178 (194) alignment 
Range on Protein: 30-194
Range on HMM: 14-178/194.0
TYITERVIAMSFPADG-----VESAYRNSIYDVSKLLNTSHKDHYLIYNLS--ERKYDYSLFNGMVLDWCGFP--DH-HAPPLGLLFKIVMTIYSWLEKD
..||.|.||...|..|     .|. ||.|. |. ..|.. .....|...|.  || ||...| .. ...  .|  |. ..|.| .|....  .. .|..|
diitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflned

PMNVVVVHCMAGKGRTGTVISALLQYGGLFeGASDAMRYFAVKRsnnnygitgPSQIRYTQYFSDIYFGGKELNP
| .||.|||.||.|||||.. | | |   .  | .|...|. ||         |..|.. .|.....   |||..
pggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.........pgaipnqdyleallkrykelrk
0039614 (Phosphotyrosine protein) phosphatases II 9-186 2.1e-31 104.9 In-house 51-288 (297) alignment 
Range on Protein: 9-186
Range on HMM: 51-288/297.0
VRKTISADKNRYE--------------NEEYDLDLTYI-----------TERVIAMSFPADGVESAYRNSIYDVS-------------------------
 ..  . |||||               ....|||..||           | ..||...| ..    . . ...                           
allpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeg

--------KLLNTSHKDHYLIYNLSERKYDYSlFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEKD-PMNVVVVHCMAGKGRTGTVISALLQ----
        .||.. |.|.| ...|. .....| .  ... . |.|||..|| | ||....  . ..|... . ..|.|||.||.|||||.| |.|     
gtygdftvtllkvehldgytvrtlevtnnges.rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleql

-YGgLFEGASDAMRYFAVKRsnnNYGITGPSQIRYTQYFSDIY
 ..     . .|....  .|   ..... |||.|. ...   .
eke.ggvdvleavkelreqR...pgavqtpsqyrflydallel
0041856 (Phosphotyrosine protein) phosphatases II 15-193 2.6e-29 97.5 In-house 2-177 (182) alignment 
Range on Protein: 15-193
Range on HMM: 2-177/182.0
ADKNRYEN---EEYDLDLTYITERVIAMSFPADGVESAYRNSIYDVSKLLNTSHKDHY-LIYNLSERKYDYSLFNGM--VLDWCGFPDHHAPPLGLLFKI
 |||||..    ....||.||.......|.||.  . .... . .| . |.. .. .. .| ||.|. |...|.. .   . . ..|||..|.|  |...
ldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldf

VMTIYSwlekdPMNVVVVHCMAGKGRTGTVISA-LLQYGGlfEGASDAMRYFAVKRSNnnyGITGPSQIRYTQYFSDIYFGGKELN
. ....     . ..|.|||.||.|||||.. | |. . |   .. .|....  .|..   ... |.|... |..   .. .|. .
ieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklg..vsleeavklvrsrRpg...mvitpnqyfflqlallellllkktr
0043336 (Phosphotyrosine protein) phosphatases II 13-182 2.9e-29 97.8 In-house 44-272 (278) alignment 
Range on Protein: 13-182
Range on HMM: 44-272/278.0
ISADKNRY-------------ENEEYDLDLTYI----------TERVIAMSFPADGVESAYRNSIYDVS-------------------------------
 . |||||             .....|||..||          ....||...| .. .  ... ...                                 
enkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygd

---KLLNTSHKDHYLIYNLSERK-YDYSLFNGMVLDWCGFPDHHAP-PLGLLFKIVMTIYSWLEkDPMNVVVVHCMAGKGRTGTVISALLQ-----YGGl
   .||.. |.|.| ...|   . .|   . .... . |.|||..| .| ||.... .. ..|| |. ..|.|||.||.|||||.| ..|      ..| 
ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeg.

FEGASDAMRYFAVKRsnnNYGITGPSQIRYTQYF
.  . .|....  .|      .. |||.|.  ..
gvdleeavkelreqR...pgavqtpsqyrflyea
0043147 (Phosphotyrosine protein) phosphatases II 24-186 1.5e-28 95.1 In-house 10-160 (172) alignment 
Range on Protein: 24-186
Range on HMM: 10-160/172.0
EYDLDLTYITERVIAMSFPadgvesaYRNSIYDVSKLLNTSHKDHylIYNLSERKYDYSLFNGMVLD--WCGFPDHHAPPLGLLFKIVMTIYSWLEKDPM
 ..|||.||. |.||. .|       .|| . |. ..| . . .|  |.|| |. ||..|.  ...   ....|||..|.| || ...  |...| ..| 
asyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspg

NVVVVHCMAGKGRTGTVISALLQYGGLfeGASDAMRYFAVKRsnnNYGITGPSQIRYTQYFSDIY
..|.|||.||.|||||.. |.| . ||   . .|....  ||   ..... |||.|. .||....
gpvlVHCsaGvgRtgtlvaaylmllgl..sleeavalvrekR...pgavqnpsqyrflyyfekll
0037934 (Phosphotyrosine protein) phosphatases II 10-183 3.4e-28 94.2 In-house 6-238 (243) alignment 
Range on Protein: 10-183
Range on HMM: 6-238/243.0
RKTISADKNRYE--------------NEEYDLDLTYITERVIAMSFPADGVESA----YRNSIYDVS---------------------------------
..  . .||||               .  ....|.|.|.|.||...| ..        . . ...                                   
llpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftv

KLLNTSHKDHYLIYNLSERK--YDYSLFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEK-------DPMNVVVVHCMAGKGRTGTVISALLQYGGL
.||...|.|.| ...|. .   .|.  .... . . ..|||..|.    | ...  .....|.       |. ..|.|||.||.|||||.| |.| .  |
tllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll

FEGASDAMRYFAVKRSNnnYGITGPSQIRYTQYFS
  .. .|....  .|..  .... |||.|. ... 
gvdleeavkllreqRpg..kavqtpsqyrflyeal
0046846 (Phosphotyrosine protein) phosphatases II 20-187 6.6e-28 93.0 In-house 3-173 (176) alignment 
Range on Protein: 20-187
Range on HMM: 3-173/176.0
YENEEYDLDLTYITERVIAMSFPADGVESAYRNSIYDVSKLLNTshkDHYLIYNLSERK--------Y--DYSLFNGMVLDWCGFPDHHAPPLGLLFKIV
.    .||||.||....|..|.|. . .. .|.   ..  |..    ..... || |..        .  ..   .|.   ....|||..|.| ||....
lrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllell

MTIYSWLEKDpmNVVVVHCMAGKGRTGTVISALLQYGGLFEGASDAMRYFAVKRSNnnYGITGPSQIRYTQYFSDIYF
  |...|...  ..|.|||.||.|||||.. |.| . . .  . .|....  .|..  . .. |.|.|. ..|   ..
efirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefellll
0042113 (Phosphotyrosine protein) phosphatases II 10-182 9.5e-28 92.7 In-house 5-238 (245) alignment 
Range on Protein: 10-182
Range on HMM: 5-238/245.0
RKTISADKNRY-------------ENEEYDLDLTYI----------TERVIAMSFPADGVESAYRNSIYDVS----------------------------
..  . |||||              ....|||..||          |...||...|...   .. . ...                              
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

-------KLLNTSHKDHYLIYNLSERK-YDYSLFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEKDPMNVVVVHCMAGKGRTGTVISALLQ-----
       .||.. |.|.| ...|.  . .|.  ...... . ..|||..|. | ||....  . ..|..|. ..|.|||.||.|||||.| |.|      
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqle

YGgLFEGASDAMRYFAVKRsnnNYGITGPSQIRYTQYF
.  |   . .|....  .|      .. |||.|. ...
ke.lgvsleeavkelrsqR...pgavqtpsqyrflyea
0040439 (Phosphotyrosine protein) phosphatases II 10-183 4.9e-26 87.3 In-house 7-242 (249) alignment 
Range on Protein: 10-183
Range on HMM: 7-242/249.0
RKTISADKNRYE---------------NEEYD--------LDLTYITERVIAMSFPADGVESAYRNSIYDVS----------------------------
..  . |||||                .. ..        .|..||. |.||...| ..  ..... ...                              
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsl

-------KLLNTSHKDHYLIYNLSERK-YDYSLFNGMVLDWCGFPDHHAP-PLGLLFKIVMTIYSWLEKD-PMNVVVVHCMAGKGRTGTVISALLQ----
       .||.. .||.| ...|   . || . .  ... . ..|||..|  .  |....  . ..||.. . ..|.|||.||.|||||.| |.|     
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql

-YGGLfEGASDAMRYFAVKRsnnNYGITGPSQIRYTQYFS
 . .    . .|....  .|   ..... |.|.|. ... 
ekelg.vdleeavkllrsqR...pgavqnpeqyrflyeal
0049260 (Phosphotyrosine protein) phosphatases II 37-184 1.7e-25 84.9 In-house 5-147 (152) alignment 
Range on Protein: 37-184
Range on HMM: 5-147/152.0
IAMSFPADGVESAYRNSIYDVSKLLNTSHKDHYLIYNLSERKYDYSLFNGMVLDWCGFPDHHAPPLGLLFKIVMTIYSWLEKDPMNVVVVHCMAGKGRTG
.||.|.. . .  ..|.. |. ..| . . .... ..  . .. .   ...   .. .|||..|.|  |..... .  .| .|. ..|.|||.||.||||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

TVISALLQYggLFEGASDAMRYFAVKRsnnNYGITGPSQIRYTQYFSD
|.. |.| .  |   . .|....  ||   ..... |.|.|. ..|..
tlvaaylml..lgvsleeavalvrekR...pgavpnpgqlrflyefek
0045450 (Phosphotyrosine protein) phosphatases II 11-183 7.9e-25 83.7 In-house 52-300 (307) alignment 
Range on Protein: 11-183
Range on HMM: 52-300/307.0
KTISADKNRYEN-------------------------------------EEYDLDLTYI----------------------------------TERVIAM
.  . ||||| .                                     . |||....|                                  . . .|.
lpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaq

SFPADGVESAYRNsiyDVSKLLNTSHKDHYLIYNLSERK--YDYSLFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEKD-PMNVVVVHCMAGKGRT
 .| .| |  |.|   .. .||...|.|.| ...|      ..   .  ... . | |||..|| .  |....  . ..||.. . ..|.|||.||.|||
ywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRt

GTVISALLQYGGLF-------EGASDAMRYFAVKRsnnNYGITGPSQIRYTQYFS
||.| |.| . .|          . .|....  .|     ... |.|.|. ... 
GtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 13-186 4.8e-24 80.6 In-house 42-275 (317) alignment 
Range on Protein: 13-186
Range on HMM: 42-275/317.0
ISADKNRY-------------ENEEYDLDLTYI----------TERVIAMSFPADGVESAYRNSIYDVS-------------------------------
 . |||||              ....|||..||          . . ||...| ..    . . ...                                 
enkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltyg

----KLLNTSHKDHYLIYNLSERK-YDYSLFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEkDPMNVVVVHCMAGKGRTGTVISALLQ-----YGG
    .||.. ..... ...|   . .|   .  ... . |.|||..|| . ||....  . ..|| || ..|.|||.||.|||||.| |.|      ..|
dftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg

lFEGASDAMRYFAVKRsnnNYGITGPSQIRYTQYFSDIY
 .  . .|....  .|   ..... |.|.|.  ..   |
.gvdveeavkelreqR...pgavqtpeqyrflydalley
0046845 (Phosphotyrosine protein) phosphatases II 12-182 5.7e-24 80.4 In-house 26-269 (284) alignment 
Range on Protein: 12-182
Range on HMM: 26-269/284.0
TISADKNRYEN-----------------------------EEYDLDLTYITERVIAMSFPADG-----------------------------VESAYRNS
    .|||| .                             . ||||||||. . ||...| ..                               . |...
penlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwpl

IYDVSKL-------LNTSHKDHYLIYNLSERKY--DYSLFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEK-DPMNVVVVHCMAGKGRTGTVISAL
. .| ..       |.. .||.| ...|. ...  .   .  ... . ..|||..|| .  |.... .. ..||. .. ...||||.||.|||||.| . 
egevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfiald

LQYGGLFEGA-------SDAMRYFAVKRsnnNYGITGPSQIRYTQYF
| .  | ..         .|....  .|   .. .. ..|.|.  ..
llleqlekeglllgvdvleavkrlreqR...pgmvqtleqyrfvyea
PH PH domain 416-511 1.4e-23 73.4 Pfam-A 2-102 (104) alignment 
Range on Protein: 416-511
Range on HMM: 2-102/104.0
VHSGYLFKKGHNFKSWRRRWFVLKDNILSYYKSPK---DTAPAGIIPINEIvNIEIECEIS--QAEGYDYCFQISTSKA-NYLISAENERDLEDWTEILR
...||| ||.. .|.|..|.|||..| |.|.||.|   . || |.||.|.. ..... .    . .  ...|.|.. .   ||.|||.| ....| . |.
ikeGyllkksellktwkkryfvLtsnyLlyfksskkksykapkgsiplndc.tvkkasstkfgaqkesnnyfeitfknvesyllsaeseeerkrWvqalk

SA
..
nl
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 193-329 3.2e-23 73.4 Pfam-A 2-134 (134) alignment 
Range on Protein: 193-329
Range on HMM: 2-134/134.0
NPGPVFLKSISMVTLPKFFLGPlkqGVCPVLNIYSATQKGVriftsaPIEGDTKETRTYQSGNATIVFEVRKIVRGDILLVFSHIT-PFYRVEQICRANF
|| ...|||| ....|.|  ..   |. | ...|. ..| .        ... |......  .... .. | .|.||.|. | |     .. |.|.|. |
npkrlelksiilegiPnfktrg...gckpkvkvyngkkkvf......kelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwF

HTGMFS--FPTLILTKSDLDGADGD--KRFSSDFHLRLDFQE
.| . .    .|.|.|..||.|. |  |.||..|...| |..
NTsFieknqnvltlpkneLDkalkdkdkkfsknfkvelvfek
0045098 (Phosphotyrosine protein) phosphatases II 25-187 1.7e-21 72.3 In-house 5-272 (278) alignment 
Range on Protein: 25-187
Range on HMM: 5-272/278.0
YDLDLTYITERVIAMSFPADGVESAYRNSIY---------------------------------------------------------------------
..|||....|.......| .  .. |.....                                                                     
asldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

----------------------DVSKLlNTSHKDHYLIYNLSERKYDYSLFNGMVLDWCGFPDHHAPPLG---LLFKIVMTIYSWLE------------K
                      ... | .. .. ..|..||. ...|.  ..  .|.. ..|||..|.|     .....  | ..|.             
kcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllll

DPMNVVVVHCMAGKGRTGTVISALLQYGGLfEGASDAMRYFAVKRSNNNY-GITGPSQIRYTQYFSDIYF
|. ..|.|||.||.|||||.. | | .  | ||  |.  ...  ||  ..  .. ..|.|.  .|   ..
dsggpvlVHCsaGvgRtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyefllell
0051082 (Phosphotyrosine protein) phosphatases II 27-182 2.3e-21 71.4 In-house 6-147 (151) alignment 
Range on Protein: 27-182
Range on HMM: 6-147/151.0
LDLTYITERVIAMSFPADgvesayrnsiyDVSKLLntSHKDHYLIYNLSERK---YDYSLFN--GMVLDWCGFPDHHAPPLGLLFKIVMTIYSWLEKDPM
....|.|........| .           |. .||   . ... |.|| . .   |......  |. . .. ..|...|.| |.|..|. . ..|.... 
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVVVVHCMAGKGRTGTVISALLQYggLFEGASDAMRYFAVKRSnnnyGITGPSQIRYTQYF
..|.|||.||||||||.. ..| .  |   . .|....  ||     |.. |.| .. |.|
gpvlvHCsaGkgRTGtlvalylml..lgvsleealeeyrlkrp....gvvqpnqqflfqlf
0048076 (Phosphotyrosine protein) phosphatases II 41-185 2.5e-21 71.3 In-house 3-141 (145) alignment 
Range on Protein: 41-185
Range on HMM: 3-141/145.0
FPADGVESAYRNSIYDVSKLLNTSHKDHYLIYNLSERKYDYSlFNGMVLDWCGFPDHHAPPL-GLLFKIVMTIYSWLEKDpmNVVVVHCMAGKGRTGTVI
.|.  ... |..|......| .  . ......||.  .....  .|. . ....|||..|.|  || ...  | ..|...  ..|.|||.||.|||||..
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

SA-LLQYGGlfEGASDAMRYFAVKRSNnnyGITGPSQIRYTQYFSDI
 | |. . |    . .|....  .|..   ... |.|.|. ..|  .
aaylmlllg..vsleealelvrsqrpg...avpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 41-184 7e-21 69.9 In-house 3-142 (144) alignment 
Range on Protein: 41-184
Range on HMM: 3-142/144.0
FPADGVESAYRNSIYDVSKLLNTSHKDHYLIYNLSERKYDYS-LFNGMVLDWCGFPDHHAPPL-GLLFKIVMTIYSWLEKDpmNVVVVHCMAGKGRTGTV
.|.  ... |..|......| .  . ......||.|  . ..  ..|. . ....|||..|.|  || ...  | ..||..  ..|.|||.||.|||||.
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

ISA-LLQYGGlfEGASDAMRYFAVKRSnnnYGITGPSQIRYTQYFSD
. | |. . |    . .|....  .|.   .... |.|.|. .....
vaaylmkklg..lsleealalvrsrrp...gavpnpgqlrfLleyek
0051299 (Phosphotyrosine protein) phosphatases II 59-179 1.3e-19 66.2 In-house 152-278 (288) alignment 
Range on Protein: 59-179
Range on HMM: 152-278/288.0
KLLNTSHKDHYLIYNLSERK-----YDYSLFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEkDPMNVVVVHCMAGKGRTGTVISALLQYGGL-FEG
.||.. ..|.| ...|  ..     .|   .. ... . ..|||..|. . ||..... ....|. .. ..|||||.||.|||||.| ..| .  | .||
tllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeg

ASDAMRYFAVKRSNNNYGITGPSQIRYT
  |......  |.  .. .. |.|.|. 
gvdvleavkrlreqRpgmvqtpeqyrfv
0047943 (Phosphotyrosine protein) phosphatases II 59-181 1.5e-18 62.7 In-house 140-266 (273) alignment 
Range on Protein: 59-181
Range on HMM: 140-266/273.0
KLLNTSHKDHYLIYNLSERK--YDYsLFNGMVLDWCGFPDHHAP-PLGLLFKIVMTIYSWLEKD-PMNVVVVHCMAGKGRTGTVISALLQ-----YGGLF
.||.. .||.| ...|  ..  ...  .  ... . |.|||..|  |  |..... . ..||..   ..|||||.||.|||||.| ..|      ..| .
tllseetkddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggv

EgASDAMRYFAVKRSNnnyGITGPSQIRYTQY
  . .|....  .| .   ... |.|.|.  .
d.vleavkllrsqRpg...mvqtpeqyrflye
0044763 (Phosphotyrosine protein) phosphatases II 17-188 2.9e-18 61.6 In-house 11-172 (178) alignment 
Range on Protein: 17-188
Range on HMM: 11-172/178.0
KNRYENEEYDLDLTYITERVIAMSFPAdgveS--AYRNSIYDVSKLLNTSHKDHYLIYNlsERKYDYSLFNGMVLDWcGFPDHHAPP-LGLLFKIVMTIY
. ....  . .....|.......|.|.    .        .... ..| .. ...  ..  . .|... ..  .| . ..|||..|. |  ....|  | 
nleglersdyinaseilpglylgslpp....addlellkelgithivnlteelelgflk..cdpywpeeagiqylhi.pipDhgvpdllehflefvefie

SWLEKDPmNVVVVHCMAGKGRTGTVISA-LLQYGGLfeGASDAMRYFAVKRsnnNyGITGPSQIRYTQYFSDIYFG
..|.... ..|.|||.||.||.||.. | |. . ||   . .|....  .|   . ... |.|.|. ..|  ....
ealdekg.gpvlVHCsaGvgRsgtlvaaylmkklgl..sleeaielvrerR...p.ivpnpgqlrqLyefelrllk
0049772 (Phosphotyrosine protein) phosphatases II 9-164 3.2e-18 61.9 In-house 41-255 (314) alignment 
Range on Protein: 9-164
Range on HMM: 41-255/314.0
VRKTISADKNRYENEEydldlTYItER-------------------------------------------------------------VIAM--------
 ..    ||||| ..       .   |                                                             .| |        
adlflnrdknryldil.....pad.nrvilpglpvsgsdyinasyvdgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------SFPADGVEsayrnSIYDVSKLLNTShkdhyliynlsERKYDYSLFNGMVLDWC--GFPDHHAPPLGLLFKIVMTIYSWlekDPMNVV
               ..||       ...... | .             |. || .|| .... ..   .||..||.|  . ...  | ..   |. ..|
elsrLdaAlgKtpllildgng.....neptaadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpv

VVHCMAGKGRTG--TVISALLQYGGLfeGASDAMRYFAVKRS
.|||.|||||||   |.  |. . |.   . .|....  ||.
lvHCkaGkgRtgtfvvaaylmkllgv..sleealedvrlkRp
0050432 (Phosphotyrosine protein) phosphatases II 59-179 1.1e-14 49.9 In-house 171-291 (308) alignment 
Range on Protein: 59-179
Range on HMM: 171-291/308.0
KLLNTSHKDHYLIYNLSERK-YDYSLFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEKdpmNVVVVHCMAGKGRTGTVISALLQYGGL-FEGASDA
.||.. ..|.| ...|  ..  |   .  ... . . |||..|| .  |....  . ..|..   ...||||.|| |||||.| ..| .  |  ||  |.
tllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdv

MRYFAVKRSNNNYGITGPSQIRYT
  ...  |.  .. ...|.| .. 
feavkklReqRpgmvqtpeqylfl
0036941 (Phosphotyrosine protein) phosphatases II 60-187 5.6e-13 44.3 In-house 141-277 (297) alignment 
Range on Protein: 60-187
Range on HMM: 141-277/297.0
LLNTSH--KDHYLIYNLSERK-YDYSLFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEKD-PMNVVVVHCMAGKGRTGTVISALLQYGG----LFE
||....  .|.| ...|   .  .   .  ... . | |||..|.    |....  . ..|..  . ..|.|||.||.||.||.| | | .      | |
llsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklke

GASDAMRYFAVKRSNNNYGITGPSQIRYTQYFSDIYF
|  |   ..   |.  .  .. ..| |.  ..   ..
ggvdileavkklReqRpgavqtleqyrflyeallell
PH_11 Pleckstrin homology domain 418-510 4.4e-12 36.1 Pfam-A 2-111 (112) alignment 
Range on Protein: 418-510
Range on HMM: 2-111/112.0
SGYLFKKGHN-FKSWRRRWFVLK-DNILSYYKSPKDTAPAGIIPIN-EIVN----IEIECEISQA----------EGYDYCFQISTSKANYLISAENERD
 ||| |||.  .|.|.||||.|. || |.|||||.|     .|  . |.|     ..|  ..|.           .    .|.| . . .. ....|. .
kGylkkkgskllkgWkrrwfiLrkdnvleYyksprdksdvalitkesekvilkkdlsisnrlskianikdkkalelshsnefsiaaeekslflkgdnnee

LEDWTEILRS
 |.| | |..
teeWvealke
0051429 (Phosphotyrosine protein) phosphatases II 40-163 4.7e-12 41.6 In-house 74-204 (272) alignment 
Range on Protein: 40-163
Range on HMM: 74-204/272.0
SFPADGVESAYRNSIYDVSKLLNTSHKDHYLIYNLSER---KYDYSlFNGMVLDWCGFPDHHAPP--LGLLFKIVMTiyswlekdpMNVVVVHCMAGKGR
 .|  . .    . .. . .|| ......|....|  .   ... . .  |.| ....|||..|.  |  |.... .          . |.|||.|||.|
hlpilddsaptilygalrvtllseellldyilrellltlllsagea.revmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdR

TGTVISALLQYGGLFEG------------ASDAMRYFAVKR
||||. .|| . |. .             . .|...   .|
TGtvvallllllgvsletivddYlltnlyleeaveelraqr
subfamily_PTPDC1_pd Subfamily PTPDC1 85-182 2.5e-09 31.8 In-house 81-171 (182) alignment 
Range on Protein: 85-182
Range on HMM: 81-171/182.0
NGMVLDWCGFPDHHAPPLGLLFKIVMTIYSWLEKDpmnVVVVHCMAGKGRTGTVISALLQYGGLFEgASDAMRYFAVKRSNnnyGITGPSQIRYTQYF
.|..   .|..|. ...|  .. ||  . . |...    | ||| ||.|||| .|.. | |   .. |..|..    ||..    |   .|..  . |
qgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrlt.aekaiklvrskrpk...siqtreqvelvkef
PH_8 Pleckstrin homology domain 421-512 2e-08 24.0 Pfam-A 3-89 (89) alignment 
Range on Protein: 421-512
Range on HMM: 3-89/89.0
LFKKGH-NFKSWRRRWFVL--KDNILSYYKSPKDTAPAGIIPINEIVnieIECEISQAEgydycFQISTSKANYLISAENERDLEDWTEILRSAK
| || .   . ...|.|||  |   ||||.. ...|  | ||... .   |... .. |     ..| .    . . |.||.| ..|.| | .||
llkkrrkklqgyakRfFvLdlksstlsYyrddnssalrgkiplslai...isaneekre.....iiidsGaevWeLkasnekdfqeWvealekak
PTPc_DSPc_SM00012 91-145 7.4e-08 27.9 In-house 7-63 (105) alignment 
Range on Protein: 91-145
Range on HMM: 7-63/105.0
WCGFPDHHAPP-LGLLFKIVMTIYSWLEKDP-MNVVVVHCMAGKGRTGTVISALLQY
. | |||..|     .....  . .. .|    . ||||| || |||||.. . . .
ytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldill
Y_phosphatase Protein-tyrosine phosphatase 62-142 9e-07 23.9 Pfam-A 108-191 (235) alignment 
Range on Protein: 62-142
Range on HMM: 108-191/235.0
N-TSHKDHYLIYNLSERKYDYSL---FNgMVLDWCGFPDHHAP--PLGLLfKIVMTIYSWLeKDPMNVVVVHCMAGKGRTGTVISAL
. ......| ...|. .| . .       ..| . . ||| .|  | .|| ...  . ..  ..  . |||||.|| |||||.... 
kekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespksll.dlirkveksk.eaksgpvvVhCsaGvgRtgtfvald
Y_phosphatase Protein-tyrosine phosphatase 62-142 9e-07 23.9 In-house 108-191 (235) alignment 
Range on Protein: 62-142
Range on HMM: 108-191/235.0
N-TSHKDHYLIYNLSERKYDYSL---FNgMVLDWCGFPDHHAP--PLGLLfKIVMTIYSWLeKDPMNVVVVHCMAGKGRTGTVISAL
. ......| ...|. .| . .       ..| . . ||| .|  | .|| ...  . ..  ..  . |||||.|| |||||.... 
kekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespksll.dlirkveksk.eaksgpvvVhCsaGvgRtgtfvald
subfamily_CDC14_pd Subfamily CDC14 16-146 1.2e-06 22.6 In-house 157-288 (328) alignment 
Range on Protein: 16-146
Range on HMM: 157-288/328.0
DKNRYENEEYDL--DLTYIT-ERVIAMSFPADGVESAYRNSIYDVSKLLNTSHK-DHYLIYNLSERKYDYSLFNGMVLDWC--GFPDHHAPPLGLLFKIV
| ..||. |     |...|. ....|.. | .  . . . ..    |||.  .| .   .  | .. || . |. . .|     | |   |.  .. | .
dleeYekyervenGDfnwivPdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfl

mTIyswLEKDpMNVVVVHCMAGKGRTGTVISALLQYG
 .|   .||     ..||| || |||||.|.. | . 
.ei...aeka.eGaiavhCkaGLGrtGtLiacylmkh
subfamily_PRL_pd Subfamily PRL 72-164 1.2e-06 22.6 In-house 39-131 (151) alignment 
Range on Protein: 72-164
Range on HMM: 39-131/151.0
YNLSERKYDYSLFN--G-MVLDWCgFPDHHAPPLGLLFKIVMTIYSWLEKDPMNVVVVHCMAGKGRTGTVISALLQYGGLfeGASDAMRYFAVKRS
    | .|| . ..  |  |||.. | |  .||  .. . .  . .  ...| ..| |||.|| ||.  ...  |   |.     ||...   || 
vrvceptydteklekegievldla.fddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm..kyedavefirekrr
subfamily_PTPRB_pd Subfamily PTPRB 60-140 1.5e-06 22.4 In-house 156-237 (293) alignment 
Range on Protein: 60-140
Range on HMM: 156-237/293.0
LLNTSHKDHYLIYNLSERKyDYSLFNGMVLDWCGFPDHHAPPL-GLLFKIVMTIYSWLEK-DPMNVVVVHCMAGKGRTGTVIS
|......... | .|. .| . .  . . ...  .|||  |     | ..| |. ...||   .. .|||| || ||||| |.
lvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfia
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 89-152 2.4e-06 21.8 In-house 181-240 (307) alignment 
Range on Protein: 89-152
Range on HMM: 181-240/307.0
LDWCGFPDHHAPPLGLLfkiVMTIYSWLEKDpMNVVVVHCMAGKGRTGTVISALLQYGGLFEGA
|.|  .||. .|.. |     . . .  . |  | ||||| || ||.||...  |    ...| 
lqwenwpdrgvpqinlt...ainlleavryd.tnpvvvhcsaGvGrsGtivaislvqdkmiaGi
DSPc_SM00195 57-141 2.5e-06 22.4 In-house 130-215 (263) alignment 
Range on Protein: 57-141
Range on HMM: 130-215/263.0
VSKLLNTSHKDHYLIYNLSERKYDY-SLFNGMVLDWCGFPDHHAP-PLGLLFKIVMTIYSWLEKDpMNVVVVHCMAGKGRTGTVISA
|    ....||.. ...|. .| .    ..  .. . . ||| .|     ..... ..... ..   . .|||| || |||||....
vklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvti
PTPc_SM00194 57-141 2.5e-06 22.4 In-house 130-215 (263) alignment 
Range on Protein: 57-141
Range on HMM: 130-215/263.0
VSKLLNTSHKDHYLIYNLSERKYDY-SLFNGMVLDWCGFPDHHAP-PLGLLFKIVMTIYSWLEKDpMNVVVVHCMAGKGRTGTVISA
|    ....||.. ...|. .| .    ..  .. . . ||| .|     ..... ..... ..   . .|||| || |||||....
vklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvti
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 63-140 3.1e-06 20.8 In-house 164-240 (302) alignment 
Range on Protein: 63-140
Range on HMM: 164-240/302.0
TSHKDHYLIYNL---SERKYDYSLFNGMVLDWCGFPDHHAPPLGllfKIVMTIYSWLEKDPMNVvVVHCMAGKGRTGTVIS
 . | .. .|..    |.| .   .   .| ....||| ||      .  . |  . |    || .||| || |||||...
ftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkea...ytaldilkfcesykknv.lvhcsaGvGrtGtlva
subfamily_PTPN12_pd Subfamily PTPN12 56-140 5.8e-06 20.4 In-house 143-226 (290) alignment 
Range on Protein: 56-140
Range on HMM: 143-226/290.0
DVSKLLNTSHKDHYLIYNLSERKYdYSLFNGMVLDWCGFPDHHAPP-LGLLFKIVMTIYSWLEKDPMNvVVVHCMAGKGRTGTVIS
 |..  .   .| .||  |  ..      .   . .  .|||  |     |.... .. .  |.. .  .|||| || |||||.|.
evtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaP.lvvhCsaGvGrtGtiia
Y_phosphatase3 Tyrosine phosphatase family 111-147 7.9e-06 21.0 Pfam-A 115-150 (164) alignment 
Range on Protein: 111-147
Range on HMM: 115-150/164.0
TIYSWLEKDPmNVVVVHCMAGKGRTGTVISALLQYGG
.... | ... . |..|| ||| ||| |.  ||.  |
kvlealaeee.gpvlfHCtaGKDRTGvvaalllsllg