Gene ptpC in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily ptpC
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP048_AA protein Get Run
DdisP048_AA_440-717 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 440-717 1.7e-82 272.5 In-house 39-300 (308) alignment 
Range on Protein: 440-717
Range on HMM: 39-300/308.0
HKHHQRHYSHNDLDNRKHdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLtpieSGDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERS
.  .. .  ...| . |   .....||.|.|  |||| |.||....||.|    ... |||||.|..| . .. | .||.|.|||.|..||||||||...
ldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnv

SVIVCLTKLEENGKKKADVYYPET--SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKarg
.|||.||||.|||..| . |.|..  .. .||| |...| .  ...|. |  |.| ..|..  |.|  .||| ||| |.||| ... ..  .|...    
rvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...

saknTNGPVIVHCSAGIGRSGTFISININMAKIERFgndpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
     .||..||||||.||.|||| . . .  .|.        .... . |  ||.|| |||||..||.|..... . | 
....pggpivVHCsaGvGRtGtfialdllleqleke......ggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0046845 (Phosphotyrosine protein) phosphatases II 460-716 1.8e-80 265.7 In-house 18-274 (284) alignment 
Range on Protein: 460-716
Range on HMM: 18-274/284.0
EKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES--GDGDYINANYINGEVP---NSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKK
 ..  || |.|. |||| |.||....||.|.....  .|.|||||.|..|      .. . .||.|.|||.|..||||||||....|||.||.|.|||..
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

KADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKG-EEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARgsaKNTNGPVIVHCSAG
| . |.|.... ..|| |...| .. ...|. |  | | ..| ....|.|  .|||.||| |.|||.... ..  .|...  .    ...||..||||||
kcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen...lpgggpivVHCsaG

IGRSGTFISININMAKIERFGNDpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
.||.|||| . . .  .|. | .   ..... . |  ||.|| ||||||.||.|..... . |
vgRtGtfialdllleqlekegll...lgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 448-715 3.7e-80 264.7 In-house 28-285 (288) alignment 
Range on Protein: 448-715
Range on HMM: 28-285/288.0
SHNDLDNRKHDeEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGevPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLT
 ...| . ..|  .. .|| |.|. |||| |.||....||.|..... ...|||||.||.|  .|. | .||.|.|||.|..||||||||....|||.||
efeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg..ynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmlt

KLEENGKKKADVYYPEtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKK----GEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakNT
||.|.|..| . |.|. .. ..|| ....| . ....|. |  |.. ..    |....|.|  .|||.||| |.|.| ... ..  .|... |     ..
klvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.....sg

NGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
.|||.||||||.||.|||| . . .  .|. |       ... . |  ||.|| |||||..||.|..... . 
ggpvvVHCsaGvgRtgtfialdllleqlekeg......gvdvleavkrlreqRpgmvqtpeqyrfvyealley
subfamily_PTPRD_pd Subfamily PTPRD 449-718 9.1e-80 263.9 In-house 29-283 (564) alignment 
Range on Protein: 449-718
Range on HMM: 29-283/564.0
HNDLDNRkhDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEVpnSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTK
.......  ..... .| .| |  ||||..... ...||.|...|   . |||||..|.|    . . ||| |.||..||.||||||||..||.|| |||
ykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnsstiVmltk

LEENGKKKADVYYPETSqAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakNTNGPVI
|||.||.| . |.||..  ..||.. . |.... ..|. . .. | || ..  |||   |.|.||| |.| |  .. .|   |.. .      ...||..
leEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne.....pdagPiv

VHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
||||||.||.|||| |.. . .|.       . .. |   | .||.||  |||| .|||||...|.. |. 
VhCSaGVGRTGtfividamlerike......ektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
DSPc_SM00195 451-715 1.1e-78 259.6 In-house 8-261 (263) alignment 
Range on Protein: 451-715
Range on HMM: 8-261/263.0
DLDNRKHDEeKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLE
.|.. .... .. .| ...|  |||| ..||...|||.|...|.  . ||||||||.|.  |. . |||.|.|||||..|||||||||....||.||. |
kleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

ENGKKKADVYYPETS-QAQEYGSFWIHLHKKVMFK-DIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGsakntNGPVI
||||.| | |.||.| . ...|.. ..| ..   | .| .  |.| |.|.| .|.|  ..|..||| |.| | .... |  .|.. | .      .||..
engkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....sgpiv

VHCSAGIGRSGTFISININMAKIERFGNdpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
||||||.||.|||..|.| . |.|.  .      ..|.. | ||| || ||||||.||.|| ..| ..
VhCsaGvgRtgtfvtidiilskleeekk......vdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 451-715 1.1e-78 259.6 In-house 8-261 (263) alignment 
Range on Protein: 451-715
Range on HMM: 8-261/263.0
DLDNRKHDEeKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLE
.|.. .... .. .| ...|  |||| ..||...|||.|...|.  . ||||||||.|.  |. . |||.|.|||||..|||||||||....||.||. |
kleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

ENGKKKADVYYPETS-QAQEYGSFWIHLHKKVMFK-DIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGsakntNGPVI
||||.| | |.||.| . ...|.. ..| ..   | .| .  |.| |.|.| .|.|  ..|..||| |.| | .... |  .|.. | .      .||..
engkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....sgpiv

VHCSAGIGRSGTFISININMAKIERFGNdpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
||||||.||.|||..|.| . |.|.  .      ..|.. | ||| || ||||||.||.|| ..| ..
VhCsaGvgRtgtfvtidiilskleeekk......vdifeivkelRkqRpgmvqtleqYlfiyeailey
0040438 (Phosphotyrosine protein) phosphatases II 448-735 1.8e-78 259.3 In-house 23-295 (317) alignment 
Range on Protein: 448-735
Range on HMM: 23-295/317.0
SHNDLDNRKHDeeKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLT
 ..||.. |.|   .  |. |.| .|||| |.||....||.|.|...  | |||||.|.  ..||  | .||.|.|||.|. ||||||||....|||.||
efedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

KLEENGKKKADVYYPEtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakNTNGPV
.|||.|..| . |.|.  . ..|| |...| . .  ..| .  |.....|.. .|.|  .||| ||| |.||| ...  .  .|... .     . .|||
eleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.....dpggpv

IVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTDMGIRSLSSPSKRRSCEM
.||||||.||.|||| . . .  .|. |      ...... | |||.||.|.|||..||.|. ..... |.  . .   |. |..  ..
lVHCsaGvgRtGtfiaaylmleqlekeg......gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkl
0036941 (Phosphotyrosine protein) phosphatases II 458-716 3.9e-77 254.8 In-house 27-277 (297) alignment 
Range on Protein: 458-716
Range on HMM: 27-277/297.0
DEEKFFSALQPNNYGKNRYHDVLPNESTRVRLtpiESGDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKAD
   ..  || |.|  ||||.|.||...|||.|   .... |||||.|.  ....  | .||.|.|||.|. ||||||||....|||.||.|.|.|..| .
llgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

VYYPET-SQAQEYGSFWIHLHKKVM--FKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargSAKNTNGPVIVHCSAGI
 |.|..  . ..|| |...| .     ..|. .  |.....|.. .|.|  .||| ||| |.|.| ...  .  .|...    .. . .|||.||||||.
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl...kllpsggpvlVHCsaGv

GRSGTFISININMAKIERFgndPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
||||||| . . .  .|.      . ...|.. |..||.|| |.||||.||.|.  .. . |
gRsgtfiaadlmlqqledk...lkeggvdileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 444-714 4.4e-77 254.5 In-house 13-270 (273) alignment 
Range on Protein: 444-714
Range on HMM: 13-270/273.0
QRHYSHNDLDNRKHdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLtpiESGDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIV
. .  ...| . |. . ..  || |.|  ||||.|.||....||.|   ..|. |||||.|.  ...|. | .||.|.|||.|..||||||||....|||
llleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyv..dgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

CLTKLEENGKKKADVYYPETSQ--AQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGSAKn
.||.|.|.|..| . |.|.. .   ..|| |...| .   ..|. |  | |...| . .|.|  .||| ||| |.||| ... ..  .|... .    . 
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.

tnGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
  |||.||||||.||.|||| . . .  .|. |      ...... |  ||.|| |||||..||.|. ... .
..gpvvVHCsaGvgRtgtfialdllldqlekeg......gvdvleavkllrsqRpgmvqtpeqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 449-714 2.9e-75 249.2 In-house 39-302 (307) alignment 
Range on Protein: 449-714
Range on HMM: 39-302/307.0
HNDLDnrkhdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES--GDGDYINANYING------EVPNSYRYYIACQAPLPSTIKDFWRMVWEERSS
 .. .       .. .|| |.|  |||| |.||...|||.|.....  .|.|||||.|..       ..... | .||.|.|||.|..|||||.||....
vtvfl.....lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvt

VIVCLTKLEENGKKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKK-GEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGsa
|||.||.|.|.|..| . |.|.... ..|| |...| ..   ... |  |..  . |....|.|  .||| ||| |.||| ...  .  .|... ..   
vivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleel..

kNTNGPVIVHCSAGIGRSGTFISININMAKIERFGNDPSqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
 . .|||.||||||.||.|||| . . .  .|. |  .    ... . | .||.|| |.||...||.|. ... .
.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlld...vdlleavkllreqRpgavqnpeqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 440-715 3.3e-75 248.6 In-house 29-288 (297) alignment 
Range on Protein: 440-715
Range on HMM: 29-288/297.0
HKHHQRHYSHNDLDNRKHDeekFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES--GDGDYINANYIngEVPNS-YRYYIACQAPLPSTIKDFWRMVWE
 . .. .. . .| . |.|   .  || |.|  |||| |.||....||.|.|...   | |||||.|.  ....   | .||.|.|||.|..||||||||
nsktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlpetvedFwrmvwe

ERSSVIVCLTKLEENGKkKADVYYPETSQaqEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKAR
....|||.||||.|.|. | . |.||...  .|| |...| |  . ... |  |.. ..||.  |.|  ..|| ||| |.|||....  .  .|... |.
qgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnnges..rtvthfqytgwpdhgvppslellleflelvrealae

GsakNTNGPVIVHCSAGIGRSGTFISININMAKIERFgndpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
    . .|||.||||||.||.|||| . . .  .|.        ...... | |||.||.|.|||..||.|..... . 
l...pkggpvlVHCsaGvgRtGtfiaaylmleqleke......ggvdvleavkelreqRpgavqtpsqyrflydallel
0043336 (Phosphotyrosine protein) phosphatases II 447-712 9.1e-75 247.0 In-house 24-273 (278) alignment 
Range on Protein: 447-712
Range on HMM: 24-273/278.0
YSHNDLDNRKHdeEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCL
  . .|.. |.  . .  || |.|. |||| |.||....||.|.....  | |||||.|.  ...|  | .||.|.|||.|..||||||||.....||.|
lefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwelgvttivmL

TKLEENGKKKADVYYPetSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakNTNGP
|.|.|.|..| . |.|  .. ..|| |...| |   ..|. |  |.. ..|. ..|.|. .||. ||| |.|.| |..  .  .|... .     . |||
telvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.....dsngp

VIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
|.||||||.||.|||| . . .  .|. |      .... . | |||.|| |.|||..||.|.....
vlVHCsaGvgRTGtfialyllleqlekeg......gvdleeavkelreqRpgavqtpsqyrflyeal
subfamily_PTPRB_pd Subfamily PTPRB 448-718 1.9e-73 242.1 In-house 30-287 (293) alignment 
Range on Protein: 448-718
Range on HMM: 30-287/293.0
SHNDLDNRKHDEeKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLT
 ...| . ..|. .  .| .. |  ||||...|| . .||.|.....  . ||||||||.|   || | .||.| |||.|..||||||||..||.|| ||
eyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgy..nsprefiatqGPlpetvddfWrmvwekkssiivmlt

KLEENGKKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSShirTLSVMVNTFKARGSAKNTNGPV
.| |.||.| . |.|...... ||.  ..| ..   .|  . .|.. |. ||  |.|  .|.| ||| | | ...   ||  .|.|.. . . .....|.
qlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekee..rkvrqyhftsWpdhgvPektk...tlldfvrtvreaiektaskrPi

IVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
.||||||.||.||||...  . .||.      .  . |   | |||..|  .||| .||||| ... |.|..
vvhCsaGvGRtGtfialdrllqaiee......edyvdifgivaelReeRnllvqtekqYifihqcvldllrk
Y_phosphatase Protein-tyrosine phosphatase 470-712 2.5e-72 238.4 Pfam-A 1-233 (235) alignment 
Range on Protein: 470-712
Range on HMM: 1-233/235.0
NYGKNRYHDVLPNESTRVRLtPIESGDGDYINANYINGEVpNsYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYP-ETSQAQE
|  ||||.|.|| ..|||.|   ..|. |||||||..|   .  . .||.|.||.|||.|||||||.|...|||.||.|||.|..| . |.| |... ..
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGSFWIHLH-KKV-MFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsaKNTNGPVIVHCSAGIGRSGTFISINI
||.. ..|  |.    |.. .. |.| ||.||  .|||  ||||.||| |.| |....  |  .|.. |     ....|||.||||||.||.|||....|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.....eaksgpvvVhCsaGvgRtgtfvaldi

NMAKIERfgN-DpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
 . ..|.  . .     ..... | |||.||.||||.|.||||. |.|
lleqlea..eee.....vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 470-712 2.5e-72 238.4 In-house 1-233 (235) alignment 
Range on Protein: 470-712
Range on HMM: 1-233/235.0
NYGKNRYHDVLPNESTRVRLtPIESGDGDYINANYINGEVpNsYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYP-ETSQAQE
|  ||||.|.|| ..|||.|   ..|. |||||||..|   .  . .||.|.||.|||.|||||||.|...|||.||.|||.|..| . |.| |... ..
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGSFWIHLH-KKV-MFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsaKNTNGPVIVHCSAGIGRSGTFISINI
||.. ..|  |.    |.. .. |.| ||.||  .|||  ||||.||| |.| |....  |  .|.. |     ....|||.||||||.||.|||....|
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.....eaksgpvvVhCsaGvgRtgtfvaldi

NMAKIERfgN-DpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
 . ..|.  . .     ..... | |||.||.||||.|.||||. |.|
lleqlea..eee.....vdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 455-718 5.4e-72 237.5 In-house 31-282 (318) alignment 
Range on Protein: 455-718
Range on HMM: 31-282/318.0
RKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGK
|....   . .|.| |  |||| ..|. ..|||.|...|.  . ||||||||.|   .. . |||.||||| ||.||||||||  |.||| ||..||.||
rseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGy..rrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergk

KKADVYYPEtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIrtLSvMVNTFKaRGSAKNTNGPVIVHCSAG
.| . |.|. .....||.  ..|...| ..|  . .... ...||  |.|   |||.||| | | |....  |. .| . . .  .|...||..||||||
akvhryWPs.kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgasl..ld.lvrqvs.kaqqksgagpivvhCsaG

IGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
.|| |.|| ..| . .|.       .  . . . | .||.||  |||| |||.||..|. . |. 
vGrtGvfiavdillerika......ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
0045098 (Phosphotyrosine protein) phosphatases II 460-714 2.4e-70 232.4 In-house 23-270 (278) alignment 
Range on Protein: 460-714
Range on HMM: 23-270/278.0
EKFFSALQPNNYGKNRYHDVLPNESTRVRltpiesgdgDYINANYINGEvPnsyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVY
 ... || ..|. ||||.|.||....||.         |||||.||.|  |   . .||.|.|||||. |||||.||....|||.||.|.|.|..| . |
seitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy.p...kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

YPEtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKK----GEEFPREVVLLHYTQWPDCGAPPSS--SHIRTLSVMVNTFKA--------RGSAKNTNGP
.|| .. ..|| |...| .  ...|. .  |...       .  .|.|  |||. ||| |.|...  ...  |  ... . .        . .. . .||
wpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

VIVHCSAGIGRSGTFISININMAKIerfgndpsQMNISIKDSVLELRRQRRG-MVQTLDQYIFIFKVIND
|.||||||.||.||.. . . .  .        . .... . | |||.||.| .||.|.||.|..... .
vlVHCsaGvgRtGtlvaaylmlell........eggvdlleavkelrsqRpglavqnleqyrflyeflle
0042113 (Phosphotyrosine protein) phosphatases II 465-713 3e-69 228.4 In-house 4-240 (245) alignment 
Range on Protein: 465-713
Range on HMM: 4-240/245.0
ALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPEt
|| |.|  |||| |.||...|||.|.|...  | |||||.|.   ... .. .||.|.|||.|..|||||.||.....||.||..||.|..| . |.|. 
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARgsakNTNGPVIVHCSAGIGRSGTFISI
.. ..|| |...| .   ..|. |  |.. ..|. ..|||. .||. ||| |.|......  .  .|... |.    . ||||.||||||.||.|||| .
gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae....dsngpvlVHCsaGvgRtGtfiaa

NINMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIN
 . .  .|. .      ..|. . | |||.||.|.|||..||.|. ... 
ylmleqlekel......gvsleeavkelrsqRpgavqtpsqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 463-714 1.4e-68 226.5 In-house 4-244 (249) alignment 
Range on Protein: 463-714
Range on HMM: 4-244/249.0
FSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYP
  || |.|  ||||.|.||....||.|.....  ..|||||.||  ..... | .||.|.|||.|..|||||.||....|||.||.|.|.|..| . |.|
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi..dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

EtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGsakNTNGPVIVHCSAGIGRSGTFI
. .. .||| |...| .  ...|. |  |.|.....  .|.|  ..|| ||| |.||| ...  .  .|... ..    ...|||.||||||.||.||||
l.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...pkggpvlVHCsaGvgRtGtfi

SININMAKIERFGNdpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
 . . .  .|. ..      ..... | .||.||.|.||...||.|. ... .
aaylmleqlekelg......vdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_PTPN6_pd Subfamily PTPN6 456-714 2.8e-68 225.1 In-house 41-295 (306) alignment 
Range on Protein: 456-714
Range on HMM: 41-295/306.0
KHDEEKfFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKK
|.  ..   . .|.|  ||||. .|| . ||| |.  .  . ||||||||..||..| ..||| |  |..|..|||||||.| | ||| .||  | ||.|
kkllsr.kegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkek

ADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLY-KKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGSAKnTNGPVIVHCSAGI
   |.|.... .|||.  ..  ..   .|  . .|..  || ..  |||. .|...||| | | . ...  .   ||. . . ... ..||..|||||||
CarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea.eagpivvhCsaGi

GRSGTFISININMAKIERFGNDpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
|| |||| |.| . .||. |.|   ..| |...|  .|.|| |.||| .|| |..|.|. 
GRtGtfiviDillkliekkgld...adidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 436-721 7.9e-67 220.3 In-house 16-284 (288) alignment 
Range on Protein: 436-721
Range on HMM: 16-284/288.0
SKKSHKHHQRHYshNDLDNRKHDEEKFfSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMV
|.....  ...|  | | . ......   . ...|  ||||...|| . .||.|.  |   . |||||.||.||  .. . ||| |.||..|..|||..|
sarnrtgfseey..nsLaalektksvt.agrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge..kkkkkyiatqgPladtvndfWelv

WEERSSVIVCLTKLEENGKKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFK
.|...| || ||.| |.||.| . |.|.. . ..|||. . | ..   .|. . .| | ||..|  .|.  ..|. ||| | | |.  .  |  .|.. .
yenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkte..leitqyqylaWpdhgvPeskapllellrqvkvan

ARGsakntNGPVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTDMGI
         ||.|||||||.||.||||...  . ..|.      .  | . . | .||.||  .|||| ||.||..|. ..  . |.
qad.....tgpiivhCsaGvGrtgtFialdalidavee......edyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgv
subfamily_PTPN12_pd Subfamily PTPN12 453-717 1.2e-65 216.3 In-house 21-278 (290) alignment 
Range on Protein: 453-717
Range on HMM: 21-278/290.0
DNRKHDEE--KFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGevPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLE
 .. ..|.  .  .. ...|. ||||.|.|| . .|| |. ||. .  ||||||.|.|  ...   ||| |.||| |..|||||.|| . ...| . .. 
sekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg..vegkleyiaaqgPLpktlddfWrmiweknveivvmaCrev

ENGKKKADVYYPETSQAQE-YGSFWIHLHKKVMFK-DIGVSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakNTNGPVI
|.|||| . |.||. . .  .|.| . |... ... |. . .|.. ...|.  |.|  .|||.||| | | | ...  |  .|....      . . |..
elgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkes..rkvyqfhYtaWPDhgvPssaksllelielvrelqe.....sedaPlv

VHCSAGIGRSGTFISININMAKIERfGNDPSqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
||||||.|| || |.|..    ... .. |.  .... | |||||.||  .||| .|| ...| . ....
vhCsaGvGrtGtiiaidyvrellka.ekipe..eldvfdlvlelrkqraalvqtkeqyelvykavaelvq
0037934 (Phosphotyrosine protein) phosphatases II 462-712 1.2e-65 216.8 In-house 2-238 (243) alignment 
Range on Protein: 462-712
Range on HMM: 2-238/243.0
FFSALQPNNYGKNRYHDVLPNESTRVRLtpiesGDGDYINANYINGEvPnsyrYYIACQAPLPSTIKD----FWRMVWEERSSVIVCLTKLEENGKKKAD
|. || |.|  |||| |.||.. .||.|     ...||||||.|..  |    ..||.|.|||.|..|    ||||.||....|||.||.|.|.|..| .
fsiallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt.p....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

VYYPetSQAqEYGSFWIHLHKKVMFKDIGVSSLHLYKKG-EEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKAR---GSAKNTNGPVIVHCSAG
 |.|  ..  .|| |...| .   ..|. |  |.|. .. ....|.|. .||. ||| |.|.| ...  .  .|..|  .     | ...|||.||||||
qywp..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

IGRSGTFISININMAKIerfgndpsqmNISIKDSVLELRRQRRG-MVQTLDQYIFIFKVI
.||.||.| . . . ..          .... . | .||.|| | .|||..||.|. ...
vgRtGtliaaylmllll..........gvdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 433-717 2.7e-65 215.6 In-house 19-291 (298) alignment 
Range on Protein: 433-717
Range on HMM: 19-291/298.0
EMASKKSHKHHQRHYSHNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIE-SGDGDYINANYINGEVPNSyrYYIACQAPLPSTIKDFW
..  ||.   ..  . . .  . . .||.   | .|.|  |||| |... .|.||.|. ..   ..||||| ....   ..   .||.||||..|..|||
avkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPltetvedFW

RMVWEERSSVIVCLTKLEENGKKKADVYYPETsQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVN
|||.|| ...|| ||.||| .| |   |.|.. ....||.. ..|..|  | |. |  |.. || ||  |||. ||.|.||| |.|  .. . .|   |.
rmvteedigtiVmltnleeldktkyhkywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvr

TfKArgsAKNTNGPVIVHCSAGIGRSGTFISINinmAKIERFGNdpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
. .     .. | ||||.||||.||||||| |.   . .||  .   .  . . . |  ||..| |.||| .||.||.... ..|.
a.sq...qqagnkpvivqCsaGvgRsGtfiaid...svlervkk...eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 470-714 3.3e-64 211.6 In-house 28-266 (274) alignment 
Range on Protein: 470-714
Range on HMM: 28-266/274.0
NYGKNRYHDVLPNESTRVRLTPIESG--DGDYINANYINGEVpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQA-
.  ||||...|||| .|| |.. .|   | .||||||| |   .  . |.| | |||.|..|||||...|...||| ||||.|. ..|  ||.|.. .. 
sqtknryktilPnensrvllesessededssyinanyikGyd.eeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

--QEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEefPREVVLLHYTQWPDCGAPPSSSHIrtLSVMVNTFKARGSAKNTNGPVIVHCSAGIGRSGTFISIN
  ..|| . |. .|.|  .|  | .| | .  .  .|.|.   ||.|||  .| . ...  |... .. ..| ....  .||.||||||||| | ||.|.
iserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantl..ldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

INMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
| . ....      .. . .   | .|| .| ||||| .|| .|....  
iavrqlre......eivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_PTPN3_pd Subfamily PTPN3 454-717 4.1e-64 211.2 In-house 25-276 (280) alignment 
Range on Protein: 454-717
Range on HMM: 25-276/280.0
NRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESgdgDYINANYINGEVPNSY--RYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEEN
 ||. . .   | .|.|  ||||.|.|| ..|||.|.  |.   |||||||.| |.| .     |||.| ||..| .|||.||||..||.|| || | |.
yrkkpglaisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlver

GKKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsaKNTNGPVIVHCS
|..|   |.|||.. .|||.| ....|.   | . .  | | .| ..  |... | |..||| | | .|... ..   |.. .     . .. ||.||||
GrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.....sgkeePvvvhCs

AGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
|||||.| .| ... .|.||.      . .. . | | ..| ||  .||| .|| |. . |  | .
aGigrtGvlilletalaliea......aepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_PTPN13_pd Subfamily PTPN13 465-718 7.5e-64 210.6 In-house 32-271 (273) alignment 
Range on Protein: 465-718
Range on HMM: 32-271/273.0
ALQPNNYGKNRYHDVLPNESTRVRLTpiesGDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS
. . .|  ||||..||| . |||.|     ..| ||||..|. .| .    ||||| ||| |.||||.|||| ...||. .|.  |.|| | . |.||. 
gkkkenkdknryrnvlPydetrvklg....deggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk

QA--QEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsakNTNGPVIVHCSAGIGRSGTFIS
.   . .. . ..| | .  ..  |..|.. ..  .  |||. |....||| | | |. .. ..   |....      . .||..||||||||||||.|.
nkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq......tdagPivvhcsaGiGrsGtlit

ININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
|.. .  |||        .. .|. | .||.||.|.||| |||||..|.| .||. 
idvvlglierdk......efdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 450-717 1.2e-63 210.1 In-house 30-284 (319) alignment 
Range on Protein: 450-717
Range on HMM: 30-284/319.0
NDLDNRKHDeeKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKL
..|.. . |  .| || ...|  ||||...|. . ||| |....   . |||||..|.|   .  . .|| ||||  ||.|||||||||.||..| ||||
kllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgy..qerekfiatqaPlentiedfWrmvWeeessivvmltkl

EENGKKKADVYYPETSqAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIrtlSVMVNTFkARGSAKNTNGPVI
 |..| |   |.||.   .||| . . | ..   .|. .. |.| || .|   |||.  .||.||| . | ..  .     ...   ..   |...||..
veklkvklkkywpeen.feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsl...ldllkri.rksrektqsgPiv

VHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
||||||.|| |||| ... . ....      .  . .   | .|| ||  |||. .||.||.... ....
vhCsaGvGRtGtfivldamlervke......egvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_PTPRG_pd Subfamily PTPRG 452-717 2.9e-62 205.7 In-house 28-288 (563) alignment 
Range on Protein: 452-717
Range on HMM: 28-288/563.0
LDNRK-HDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDG--DYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKL
| ..  ... .  .. .|.|  |||| .... ...||.|.|.   ..  ||||||||.|   .  . .|| | ||..|..|||||.||.....|| .|.|
lqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGy..qkskafiatqgplkdtfddFWrmiWeqnvaiivmitnl

EENGKKKADVYYPEtSQAQEYGSFWIHLHKKVMFKDIGVSSLHLY-----KKGE-EFPREVVLLHYTQWPDCGAPPSsshirTLSVMVNTFKARGSAKNT
.|.|..| |||.|.  ....||.. . | .. ..    | .| .      || . .  ..|   |||.|||.|.| .     .| |. .  |.  . |..
vergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh.....slpvLifvkkssaankae

NGPVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
 ||..||||||.||.||.| ..  . .|..      .  . . . .  .| ||  .||| .||||..... ....
aGPivvHcsaGvgrtGtyivldtllkqiqq......enavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 464-717 3.6e-61 201.7 In-house 35-277 (281) alignment 
Range on Protein: 464-717
Range on HMM: 35-277/281.0
SALQPNNYGKNRYHDVLPNESTRVRLTPIE-SGDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPE
.. ...|  ||||...   . |||..|| | . . ||||||...|   .. . |||.|.|.|.....||.||||.. |.|| .|.  |.|| |   |.|.
askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgy..kgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPd

TSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsAKNTNGPVIVHCSAGIGRSGTFIS
 ... .|| . .. ... . .      ..|.... | .|||. |.||.||| |.| .....      |. ..     |.|. |...|||||.||.||.|.
dnselkygdvtvkstaeeekatyierkfkleresge.treveqlaytaWPdhGvPattkellefrkevlklt....ekktkaplvihCsaGvGrtGtyia

ININMAKIERfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
..  . ..|.     .. ....|. | |||..|  ||||. || |..|.. |.| 
lDrlvkavea.....eleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 466-717 6.1e-60 197.5 In-house 5-243 (250) alignment 
Range on Protein: 466-717
Range on HMM: 5-243/250.0
LQPNNYGKNRYHDVLPNESTRVRLTPIE-SGDGDYINANYINGEVPNsyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKkADVYYPeTS
 .|.|  |||| |... .|.|| | . .   . ||||| ...|   .  . .|| |.||..||.||||||.|| |..|| ||.|.|..|.    |.| . 
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP.ve

QAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsaKNTNGPVIVHCSAGIGRSGTFISIN
.|..||.  ..|..| .| |. .  | | |. ..  | |. ||...||| | |     .  |   |.. .     .  |.||||.||||.||||.|| |.
kaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqq....qagnaPvivqCsaGvgrsGafiaid

inmAKIERFGNdpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
   | .||  .   .  . . . .  ||..| ..|..|.||.|....|   |.
...avlerlkk...ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN14_pd Subfamily PTPN14 455-716 1.3e-59 196.7 In-house 34-296 (300) alignment 
Range on Protein: 455-716
Range on HMM: 34-296/300.0
RKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKK
.|. . .. .|  |.|  |||..|||| | .||.|.| .  . .||||  |.  |  . | ||..|.||. |..|||.||||.  ..|| ||. ||.||.
kkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgke

KADVYYPET---SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSH----IRTLSVMVNTFKARGSAKNTNGPVI
|.  |.|..    .  |.| | .  . .   . .  ..|.|.    .  |.|. | || ||| | |.  ..    .. .  . . ..   ..|... ||.
ksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvl

VHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
||||||.||.|  |  .. .| .|       . .| || ..  ||.||  .|||| || |..||.   |
vhCsaGvGrtGvlilsdlliatleh......neeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 439-717 2.5e-59 195.9 In-house 11-284 (305) alignment 
Range on Protein: 439-717
Range on HMM: 11-284/305.0
SHKHHQRHYSHNDL----DNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRM
.. ...| || ..|    ..  ..||...   . .|  |||.... . .  |..||. || |  |||||.|..|   ..   ||. |.||..|..||||.
ayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgy..krkkkyivaqgPlkntvadfWrl

VWEERSSVIVCLTKLEENGKKKADVYYPETSQA-QEYGSFWIHLHKKVMFKDIGVSSLHLYK-KGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVN
..||. |.|| |||| |.||.|   |.||. .  .|.|.| ..|. .  ..|     |.. . ....  | |. .. |.||| | | ... . .|   |.
iveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvq

tfKArgSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
  |.    |. . |..||||||.||.|.||...| . .... .       . . . . .||..| .|||||||| |.. .... .|
..kd..qkkdkgvpllVhCsagvgRtGvfiavdialerlkkEe......vvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Ptp69D_pd Subfamily Ptp69D 436-726 9.1e-58 190.8 In-house 15-300 (307) alignment 
Range on Protein: 436-726
Range on HMM: 15-300/307.0
SKKSHKHHQRHYSHNDLDNRKHDEEKFFSALQPNNYgKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMV
|.| . ..     .. | .|. | .  .|. . |.  ||||.|. . ..|||.|..|.   | |||||..|.|   .  . .|| |.|. .||.|||||.
srkrdtdfglakeyekLeareidkstkvsekkenal.knRyedikafDktRvkLkkingkedsdYinasfikgy..kekkkfiaaqdPveatigDfWRmi

WEERSSVIVCLTKLEENGKKKADVYYPETsQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEF-----PREVVLLHYTQWPDCGAPPSSSHIRTLSVM
.|  . .|| |..|.|  .|| . |.|.  . ..||.  ..| ..   .|    .|.. ||.||       |.||  |||.|.|  .| ..  .  |  .
aeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieq

VNTFKARGsakntNGPVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT----DMGIRSLS
|.  .        ..|..|||||| ||||.|..... . ...         ...| . | .||.||  .|| |.||.|... . |  .    |. ...|.
vrelykln.....rsPivvhCsaGvgrsgifvaldsllqqlka......edkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddle

S
.
d
subfamily_PTPN9_pd Subfamily PTPN9 456-712 1.1e-57 190.3 In-house 28-286 (297) alignment 
Range on Protein: 456-712
Range on HMM: 28-286/297.0
KHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKK
.  | .|  . .. |  ||||.|||  ..||| |. ..  .  ||||||...|   .  . .|| | ||. |..||||||||..  |||  |...|.|. 
epveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGy..kqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrl

KADVYYP-ETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRT--------LSVMVNTFKARGSAKNTNGP
|   |.| |. ...|.|.. ..  . .. .|  |..|....  .|  |.|.   .. ||| | | |.. .           ...|... ..   . .. |
kcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPP

VIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
..|||||||||.||||...|.....|. |      .. . ..|  || ||  ..|| .|| | .. .
ivvhcsaGiGrtGtfitldiclsrleevg......tvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_PTPRA_pd Subfamily PTPRA 461-720 2.4e-57 189.3 In-house 49-303 (330) alignment 
Range on Protein: 461-720
Range on HMM: 49-303/330.0
KFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVY
 .  | . .|  |||. ..||.. .|| |...|   . ||||| .|.|   .   ..||.| |.  |..|||||.|| .|. || ||.|.|  ..|   |
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGy..kekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy

YPETSqAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGE----EFPREVVLLHYTQWPDCGAPPSSshIRTLSVMVnTFKArgSAKNTNGPVIVHCSAGIG
.|.   .  ||   ........ .|. |  . . ....    . .| |  .|.| ||| | |  .  |  |...    |.    ... ||..||||||.|
wPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep..iGmlkllk.kvkk..lnqqsagpivvhcsaGvG

RSGTFISININMAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV----LTDMG
|.|||| ..  .....      ..  . . . | .|| ||  ||||. || ||.||. .      |.. 
rtGtfivldavlervk......aerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteld
subfamily_PTPN23_pd Subfamily PTPN23 451-712 3.2e-57 188.5 In-house 23-276 (288) alignment 
Range on Protein: 451-712
Range on HMM: 23-276/288.0
DLDNRK-HDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTpieSGDGDYINANYINGEVPNSYRyYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLE
.|.... .. .|.  |.   .  |||..|.|| ...|| |    ..  ||||| .... .| .   .|| ||||.||. |||.||.|..|||||.|.. |
eleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvyeqkssviVmllske

ENGKKKADVYYPET-SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNT-FKARGSAKNTngPVI
| ||.|.| |.||   .....| . . |...   .      |.|  ....  ..|..|..|.||. |.| | ...  .   |.. ..|.    .|  |..
elgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt..Plv

VHCSAGIGRSGTFISININMAKIerfGNDPSQMniSIKDSVLELRRQRRGMVQTLDQYIFIFKVI
||||||.||.|.|  .   ....    ...  .   | . |  ||.||| |||. .|. | ....
vhCsaGvgRtgvfalvyaavrel...ekgngll..diiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 453-713 3.9e-57 188.3 In-house 5-261 (270) alignment 
Range on Protein: 453-713
Range on HMM: 5-261/270.0
DNRKHDEEKFFSALQPNNYgkNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGEVPNsYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEEN
|. ...|... .| . ...  |||.|.||.  ||||| ..|. .   ||||||..|   .  ..||| ..|||.|.|.||||.|||... || .|.|||.
dkeetsesdlpeaargkkl..nRyadiLPsPatRvrleeleedsataYinAnyvrGfdge.kkkYiaamgPlpttlksfwrmiweekvtaivmttgleEk

GKKKADVYYPETSQA-QEYGSFWIHLHKKVMFKDIG--VSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSSH---IRTLSVMVNTFKARGSAKNTNGP
|.|| ..|.|. ..   ..    |.  .    |. |  .  |.| .||||  |..|  .|..||| |.|... .    . |  |... ..  . .. ..|
grkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgee..rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaeP

VIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIN
..||||||.||.||.| ..| .  .|.      .... .   . |||..|  .||. .|| |..|.. 
llvHcsaGvgRtGtlialDiavrlLee......tkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_PTPN1_pd Subfamily PTPN1 451-712 7.8e-56 183.9 In-house 14-267 (290) alignment 
Range on Protein: 451-712
Range on HMM: 14-267/290.0
DLDNRKHdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLtpiESGDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEE
|...  . . .  .| .|.| ..||| || | . .|..|   |..| |||||. .  |...  | ||  | |||.|.. ||.||||..|  .| | |. |
dirkeas.dfptreaklpenrnlnryrdvspydhsrikl...eradndyinaslv..eleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvve

NGKKKADVYYPETSQ--AQEY--GSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIrtLSVMvNTFKARGSAKNTNGPV
... |   |.|.  .  . ..   .. ..| .. . .   |. |.| ..  .  ||..  |||.||| | | | .    |. .    .  || ..  ||.
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaf..lkfl.fkvresGslssdvGpa

IVHCSAGIGRSGTFISININMAKIERFGNDpSQmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
..||||||||||||. ..  ...||. ..  |   . ||. .||||..| |..|| ||  | .  |
vihcsaGiGrsGtfclvdtclvliekkddl.ss..vdikkvllelrkyrlGliqtadqlrfsylai
subfamily_PTPRK_pd Subfamily PTPRK 462-714 9.3e-55 180.6 In-house 35-275 (314) alignment 
Range on Protein: 462-714
Range on HMM: 35-275/314.0
FFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYY
. .| . .|  |||..|.|. . .||.|..|.   . |||||..|..   .  . .|. | ||..|.|||||.|..|... || ||.| |.|. |   |.
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsy..krpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyW

PETSQAqeYGSFWIHLHKKVMFKDIGVSSLHLYK--KGEEFPREVVLLHYTQWPDCGAPPSSshiRTLSVMVNTFKARGSAknTNGPVIVHCSAGIGRSG
|| ..   || . ..| .  . ... |  . ..|  .| |  |||  .....||| . | |    ..|  .|   |.      ..|...|||||| ||.|
Pedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsa...tgllklvrrvkksqee..eaGrivvhCsaGaGrtG

TFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
||| |.| .  |||      .  . .   | .|| ..  ||.| .||.||. || .
tfiaidivldmier......egvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 441-717 6.8e-52 171.3 In-house 15-278 (315) alignment 
Range on Protein: 441-717
Range on HMM: 15-278/315.0
KHHQRHYSHNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPI-ESGDGDYINANYINGeVpNSYRYYIACQAPLPSTIKDFWRMVWEERS
..|   .|..  |    |  .  .| ...|. ||||...|| .|.||.|  | .| | ||||| ||.. | .. . ||| |.||.....||||||..|. 
nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiks.v.dddkayiasqgPlkasvddfwrmvlqekv

SVIVCLTKLEENGKKKADVYYPE-TSQAQEYGSFWIHLHKKVMFKDIGVSSLhLYKKGEEFpREVVLLHYTQWPDCGAPPSSShirTLSVMVNTFKARgs
. || .||..|. | |   |.|.  ... |.||. ..| .     |  .  |   .|.||  | |   ..|.||| |..  .|   .|  ..   ||   
ttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrksees.rtvtqfqftewPdkGvdkqts...sllklikevkad..

AKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
 .. . ...||||||.||.| .|||.  .|.|.|      .  . . . | .||..|  .||| ..| ||. .. . | 
ngkkefsllvhcsaGvGrtGvvisidevvaqikr......trsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 467-714 1.7e-50 166.8 In-house 46-277 (315) alignment 
Range on Protein: 467-714
Range on HMM: 46-277/315.0
QPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETsq
. .|  ||||..... . .||.|  .|   . ||.|||.|.|   |  | |||.|.|.....|||||.|.||  . || ||.| |. |.||. |.|.   
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGy..nkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..

AQEYGSFWIHLHKKVMFKDIGVSSLHLYKKgeEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFkargsAKNTNGPVIVHCSAGIGRSGTFISINI
   || . . . .. ..... | .|    .  .  |||| |||| ||| | | ..  .  |   |. .      .|. |...||||||.||.||||... 
kviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirtvkqh.....htnsvgaivvhcsaGvGrtGtfitlda

NMAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
 . ..|       .  | . . .  .|..|..|||...|| ||.... .
vldqae......aenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 441-722 4e-50 165.8 In-house 19-298 (325) alignment 
Range on Protein: 441-722
Range on HMM: 19-298/325.0
KHHQRHYSHNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRL-TPIESGDGDYINANYINGEVPNsyRYYIACQAPLPSTIKDFWRMVWEERS
 . |  ..|.       |   .  | .|.|  |||...|.. . .|| | |  .... |||||.|.. ..      ..|.||||..||.|.||.| . |.
aqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk..dvflaaqaPltatindlWrlvldWrc

SVIVCLTKLEEnGKKKADVYYPET-SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGS
||.| | .|.. ||..  ||.|.  ......|.. ..|     . |     |.. .  .   | |  ...  |.| | .   . . ..  .|.. . |  
svvvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

A-KNTNGPVIVHCSAGIGRSGTFISININMAKIErfgNDpSqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL----TDMGIR
|  .. .|..||||||.||.|.|||.   .||.    .. |  .. | ..|  ||..|  ||.| ||||.|.. . ...    ||. . 
antkastpilvhcsaGvGrtGvfislysalakvi...ee.s..rvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvs
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 446-718 6.8e-50 164.6 In-house 23-285 (290) alignment 
Range on Protein: 446-718
Range on HMM: 23-285/290.0
HYSHNDLDNRKHdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-D--GDYINANYINGEvPNSYrYYIACQAPLPSTIKDFWRMVWEERSSVI
.  .. ||. .. |..   .| ..|  .||........  |. | || .  |   .|||| ||.|   ...  ||| |.|...|..|||...|.|....|
rnqfkmldsges.ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgy.kekk.qyiatqgpvsntlvdFWkliwqekvtii

VCLTKLEENGKKKADVYYPETSQAQeYGSFWIHLHKKVMFKDIGVSSLHLYKKGE-EFPREVVLLHYTQWPDCGAPPSSSHIrtlsVMVNTFKARGSAKN
| ||.  |.||.|   |.|...... || | |.|..  .....    |.. .| . . ...|. .. | |.. |  .  . |    ..| .   .   |.
vmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqti....llvieemyktqrkr

TNGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
.|....||||...|||..|..... . | .  |       | . . . ..| |. |.||| .|| .||...   |. 
gntsivvHCSdtvgrsavfcaaattinkckteg......vidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 437-717 1.8e-49 163.3 In-house 12-279 (287) alignment 
Range on Protein: 437-717
Range on HMM: 12-279/287.0
KKSHKHHQRHYSH--NDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTpieSGDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMV
.| |.. .  ...    |.. ...|..   .. ..|  |||....|. .  || |      . ||||| .|.|   .. . .|....|. .|...||...
akghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgy..kekkafiiaesPmfntarnfWkli

WEERSSVIVCLTKLEENGKKKADVYYPETSQaQEYGSFWIHLHKKVMFKDIGVSSLHLYKKG-EEFPREVVLLHYTQWPDCGAPPSSSHIrtLSVMVNtf
.... ..|| |....|| ...   |.||..    .| . |.| .. . ..  .  |.. .|. .. ...|.  ..|.|.. |  ..   |  | |. .  
ddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqti..llviee..

KARGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
. .   |..|....||||...|||..|..... . | .. |       | . . . . | |. |.||| .||.||....   |.
myktqrkrgntsivvhCsdtvGrsamfcaaattinkckteG......viDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 461-712 2.7e-49 163.2 In-house 53-287 (319) alignment 
Range on Protein: 461-712
Range on HMM: 53-287/319.0
KFFSALQPnNYGKNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTkleengKKKADVY
. |. |.. |  |||. ..|. . ..|.| ...  .  ||||| ...|    .   |||.| ||. |..|||||.|| ..| || ||      |.|   |
qtfanldq.nkdknriinilafdknvvklerliGeefsdyinasfvtGy..qrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

YPETSQaQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIRTLsvmVNTFKARGSAKNTNGPVIVHCSAGIGRSG
.|   . .... | ....     ..  | ...| ..|.|   |..   |.  ||| | | ..| . .|   |.  .   | .| . ...||||||.||.|
wplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrl...vkkvrhltskenhranivvhcsaGvGrtG

TFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
..| ... . ....      .  . . . | .||.||  .|| | || ||.  .
vyivldvlldrmke......ekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 469-716 2.7e-49 162.6 In-house 42-276 (515) alignment 
Range on Protein: 469-716
Range on HMM: 42-276/515.0
NNYGKNRYHDVLPNESTRVRLTPIE-SGDGDYINANYINGeVpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPE-TSQA
 |. ||||...|| .|.||.|  |. . . ||.|| ||.. . .. . ||| |.|......||||.|..|. . |. .|||.|. | |   |.|.  ...
infkknryknilPydsvrvklevindnPhsdyfnasyips.f.dndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

QEYGSFWIHLHKKVMFKDIGVSSLHLYKkGEEfPREVVLLHYTQWPDCGAPPSsshIRTLSVMVNTFKArgSAKNTNGPVIVHCSAGIGRSGTFISININ
 ..||. ..|       .     |.. | |..  | |   |.|.||| |.|.     ..|  ..   ||  .  . . |.|.|||||.|| | .|||.  
vkfGsikvelvsleactggikrkltvlk.gdd.srtvtqfhfteWPdkGvpkh...tssllklikevka..dhgqythpliihcsaGvGrtGvvisidsv

MAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
.|...          . . . |  .|..|  .||| .|| ||. .. . |
vahakt......trmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 462-712 6.2e-49 162.0 In-house 18-251 (284) alignment 
Range on Protein: 462-712
Range on HMM: 18-251/284.0
FFSALQPnNYGKNRYHDVLPNESTRVRLTPIESGD-GDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTkleengKKKADVYY
 |. |.. |  |||. ..|. . ..|.| ..   .  ||||| .|.|    .   |||.| ||. |..|||||.|| ..| || ||      |.|   |.
tfanldq.nkdknrighilafdknvvklerliGeefsdyinasfitGy..qrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PETSQaQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIRTLsvmVNTFKARGSAKNTNGPVIVHCSAGIGRSGT
|   . .... | ....     ..  | ...| ..|.|   |..   |.  ||| | | ..|.. .|   |.  .   | .| . ...||||||.||.|.
plkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrl...vkkvrhltskenhranivvhcsagvgrtgv

FISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
.| ... . ....      .  . . . | .||.||  .|| | || ||.  .
yivldvlldrmke......ekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 461-712 9.9e-48 157.4 In-house 29-273 (287) alignment 
Range on Protein: 461-712
Range on HMM: 29-273/287.0
KFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDGDYINANYINGEVPNsyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYY
 | .| .  .  |||| |||| . ||| |.       |||||||. .   .    .||.|.|...|..||||.|.|.||.... .|.  |....|.  |.
tfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytdd..eafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykyw

PETSQAQEYGSFWIH-LHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMV-NTFKARGSAkNTNGPVIVHCSAGIGRSG
||  .    | . .  | ....  . || .| | .   .  | |  |.. .||| ...|..  .  . . | .  ... .| .  ||..||...||||||
PerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielarda.sevGPlvvhddvGiGrsG

TFISININMAKIERFGNdpsqmnISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
..... . . . |  |.      . .   |. || .|...||.  |. .... .
illatlvlvsrledlGr......vdvaavvirlreyraalvqavvqlrllyeal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 469-717 4.5e-47 155.6 In-house 50-285 (297) alignment 
Range on Protein: 469-717
Range on HMM: 50-285/297.0
NNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGevpNSYrYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKkKADVYYPETSQAQ
 |. |.||...|| .| ||.|  ...  | ||.|| ...|   | .  .|. | | ..|..|||.||..|. |.|| |....|. | |   |..... ..
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg...nkh.rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt

eYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGApPSSSHIRTLSVMVNTFKARGSAKNTNgPVIVHCSAGIGRSGTFISININM
 .|.  . |.     .     .|.. |      | |   ....|||    .   ....|  ...  .   | .. . |..|||.||.|| | ...|.  .
.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkav.erkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvv

AKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
|...|      . .. | . |  ||..|  .||| .|| |........| 
aeakr......ekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_PTPRN_pd Subfamily PTPRN 449-713 1.5e-46 153.4 In-house 35-289 (297) alignment 
Range on Protein: 449-713
Range on HMM: 35-289/297.0
HNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESG-DGDYINANYINGEVPNSyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTK
 . | . . ...    | ...|  |||...||| . .||.|.   |  . |||||  |  . | .   |||.|.||.||. |||.||||. . ||| ||.
wealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpra.payiatqgplastvadfwqmvweqGvvvivnltr

LEENGKKKADVYYPETSqAQEYGSFWIHLHK-KVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfKARGsaknTNGPV
|||.| |. . |.|..  .. |. . .||   ..  .|  | |..|     .  | |  .|.  ||. |.|.|.  .  .   ||    ||       |.
leeegvkqckrywpdeG.sevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk.syrG....rscpi

IVHCSAGIGRSGTFISININMAKIERfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIN
.||||.| ||.|..| |.. .... .        .| |  ..  || || |.|.| ||. |..... 
vvhcsdGaGrtGvyilidlvlnrllk.....Gvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 469-712 3.7e-46 152.3 In-house 2-235 (237) alignment 
Range on Protein: 469-712
Range on HMM: 2-235/237.0
NNYGKNRYHDVLPNESTRVRLTPIESGdGDYINANYINGeVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQAQE
.|  |||| ..   . .|| |    ||  |||||.|..| .  . . |||.| || |. .|||.|||.|. |||| || | |. ..|   |.|.| | . 
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGSFWIHLHKKVMFKDIGVSSLHLYKKGEEF-PREVVLLHYTQWPDCGAPPSSSHIrtLSVMVNTFkARGSAKNTNGPVIVHCSAGIGRSGTFISININM
|| . . |.||  | |  | || | |...    | .   ..| ||| | |  .. .  |    |    |    .  || |.|||||.||.| |. |.  .
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaal..lrfrknii.nrsphvsesgpwiihcsagvgrtgiflvidaml

AKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
 . .       .  . | . |  .  .|  ..|| |||.||...|
rqak......ekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0041856 (Phosphotyrosine protein) phosphatases II 470-712 2.2e-44 146.6 In-house 1-167 (182) alignment 
Range on Protein: 470-712
Range on HMM: 1-167/182.0
NYGKNRYHDVLPNESTRvrltpiesgDGDYINANYINGEVPNSYryYIACQAPLPSTIKDFWRMVWEERSSVIVCLTkleengkkkADVYYPetsqaqey
|. |||| |.||.. .|         | ||||||.. |  |..   .||.|.||.||. ||.||..|.. ..||.||          . |.|        
nldknrysdilpydhsr.........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

gsfwihlhkkvmfkdigvsslhlykkgEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNtfkargsaknTNGPVIVHCSAGIGRSGTFISININMAK
                           |...|... ..|..||| |.|. .. .. .  . .           .|||.||||||.||.||.. . . . .
...........................ellerlgiqylylpwpDhgvpdldelldfieevle..........eggpvlVHCsaGvgRtgtlvaaylmkkl

ierfgndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
           ..|. . | ..|..| |||.|..||.|.  ..
...........gvsleeavklvrsrRpgmvitpnqyfflqlal
subfamily_CG7180_pd Subfamily CG7180 457-715 7.1e-44 144.6 In-house 29-289 (296) alignment 
Range on Protein: 457-715
Range on HMM: 29-289/296.0
HDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINGEVPNsyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKkK
 . ..   .|. .| .|||. .|.| . .|| |. ..   . ||||| |... . .  . ||  .||  .|...|||.|..| .| .| |||  .  | .
leigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkk..keyivteapkketvdefWrlvydeeisavvvLtktfdfak.m

ADVYYPETSqAQEYGSFWIHLHKKVMFKDIGVSSLHLYKK---------GEEFP-REVVLLHYTQWPDCGAPPSS-SHIRTLSVMVNTFKARGSAKNTNG
   |.|..|  ..|| . ... ..  . ..    ..|.||         ... . | | |...|.|.     |.| . .  |  .|.... .   ....|
ypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeeg

PVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
||.|..| | .||| ...|..|. ..|.      . .. . . |  |||.|...|.. ..| .|. |... 
PvvvvssdGasRsGvylaidanlelvek......eeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
0049772 (Phosphotyrosine protein) phosphatases II 457-714 1.2e-43 145.4 In-house 33-278 (314) alignment 
Range on Protein: 457-714
Range on HMM: 33-278/314.0
HDEEKFFSALQPNNYGKNRYHDVLPNEsTRVRLTPIESGDGDYINANYINGEvpnsyRYYIACQAPLPSTIKDF----------WRMV--WEERSSVIVC
  |  .  | .. |  ||||.|.|| . .||.|   .  . |||||.|..|      . .||.|.||. |. ||          ||||  .. .. .||.
lpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------LTKLEENGkkkadvyypetsqaqeygSF---------WihlhkkvmfkdigvsslHLYKKGEEFPREVVLLHYTQWPDc
                     |..| .||                  ..                             .  .| |.|... .... .|| 
srdevladelsrLdaAlgKtpllildgng..................neptaadlellk.................eelydpelferlgikylripvpD.

GAPPSSSHIRTLSVMVNTFkargsakNTNGPVIVHCSAGIGRSGTFISININMAKIerfgndpsqmNISIKDSVLELRRQRR-----GMVQTLDQYIFIF
| .|...... .  .....       ...|||.|||.||.||.|||. . . | .           ..|... . ..|..|      |....|.||.||.
gsaplledfdeflefieea.......dkggpvlvHCkaGkgRtgtfvvaaylmkll..........gvsleealedvrlkRpinpnpgfieqleqyefil

KVIND
.....
ealle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 468-712 1.8e-43 143.5 In-house 31-262 (283) alignment 
Range on Protein: 468-712
Range on HMM: 31-262/283.0
PNNYGKNRYHDVLPNESTRVRLTPIESgdgDYINANYIN-GEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSqA
 .|  |||.....| .  ||.| .      ||||| .|   .  .  . ||..|.||  |..|||.||..|. . || |||| |. ..|   |.|.   .
denkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.s

QEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfPREVVLLHY--TQWPDCGAPPsssHIRTLsVMVNTFKARgSAKNTNGPVIVHCSAGIGRSGTFISIn
..|| | . |.| .  .   .  | | ...     ...| ||   .| ..|  .    | .| | .|  ..    .. .||..||||.||||...||.. 
edyGeftvtlrkettsnsfiikelllrvnssa.kstlllahyqvidWleygeqa...iinsl.vkfnkvisl.qteskkgPivvhCstgiGrtavfiaa.

inMAKIERFGndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
  .| ..      ..  . .   |  .| || ..||||||| .. ...
..sasvkdal...tesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 470-714 2.5e-43 143.2 In-house 48-277 (439) alignment 
Range on Protein: 470-714
Range on HMM: 48-277/439.0
NYGKNRYHDVLPNESTRVRLTPIE-SGDGDYINANYINGEVPNsyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKkkadvYYPETSQaQE
.  ||||.|| . . ||| |  |       |||||||.|   .  . |||.|.|   | .||||.|.|.... || ||.| |  |     |.|  ..   
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyydd..klyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae.vc

YGSFWIHLHKKVMFKDIGVSSLHLYKKGEE--FPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfkarGSAKNTNGPVIVHCSAGIGRSGTFISININ
||   ..  ... . .  .  ...... .     | |. .||. |||   |  .||.  .   .|.       |.  |||.||||||.||.|| |...| 
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrains....andkeeygpvvvhcsagvGrtGtiialdia

MAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
. ..       .. .. ||  |  ||.||. |||.| ||.||.. . .
leqlk......lenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 450-716 2e-40 133.4 In-house 22-293 (301) alignment 
Range on Protein: 450-716
Range on HMM: 22-293/301.0
NDLDNRKhdEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIES---GDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLT
..|.. .  ...    |. .|   ||.... . .  |. |.| ..      .||||.||.|   .. . .|| |.|. .|..||||..|.|. . || .|
kelkege..dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgy..sekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt

KLEENGKKKADVYYPETSQ-AQEYGSFWIHLHKKVMFKDIGVSSLH---------------LYKKGEEFPREVVLLHYTQWPDCGAPPSSshIRTLSVMV
.|.|. |.|.  |.|....  .|.| | . |... .. |  . .|                . .| .  ...|. |. |.||. |  .       | |. 
nlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep..rtvLqvid

NTFKArgSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
.  ..    |   |||.||||....|||...|..| .    .      .  . . . .  .||.. |.|.||.||..|..||.  |
dvihr..qqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka......egVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 446-716 8.2e-40 131.4 In-house 21-237 (392) alignment 
Range on Protein: 446-716
Range on HMM: 21-237/392.0
HYSHNDLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPI-ESGDGDYINANYINGeVpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVC
 ....  |    |  .  .| .. |  ||||...|| .|.||.|  | .. | ||.|| ||.. . .. . |||.|.| .....||||||..|. . |. 
lffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyips.f.dnekayiasqgpnaaslddfwrmvfqenvttiam

LTKLEENGkkkadvyypetsqaqeygsfwihlhkkvmfkdigvsslhlykKGEEFpREVVLLHYTQWPDCGAPPSSShirTLSVMVNTFKARGSakNTNG
.|||.|                                            ||..  | |   |.|.||| . |  .|   .|  ...  ||     .   
vtklkegd..........................................kgdda.rtvaqfhftewPdkdvpkhts...sllkfikevkadfG..qyth

PVIVHCSAGIGRSGTFISININMAKIERfgndpSQMnISIKDSVLELRRQRRGMVQTLDQYIFIFKV-INDVL
|.|.|||||.||.|  |||.  .|. ..     ..| . . . | ..||.|  |||| .|| ||.   ..|.|
pliihcsagvgrtgvvisidsvvahakk.....trm.vdvfnfvtnirrkrpymvqtkeqyafiygavledll
0051429 (Phosphotyrosine protein) phosphatases II 497-717 8.3e-40 132.5 In-house 4-226 (272) alignment 
Range on Protein: 497-717
Range on HMM: 4-226/272.0
GDYINANYINGEvpNS---YRYYIACQAPLPSTIKDFWRMvWEERSSVIVCLTKLEENGKKKADVYYP-----------ETSQAQEYGSFWIHLHKKVMF
..||||....|   ..    ........||| |..||||. .|.. ..||.|...|| |. | | | |           .. .  .|| ... |......
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

KDIGVSSLHLYKK-GEEFPREVVLLHYTQWPDCGAPPSSsHIRTLSVMVNtfkargsakntNGPVIVHCSAGIGRSGTFISININMAKIE--RFGNDPSQ
 |. .  | |... . . .||| .||||.||| |.|...  .. |... .           .|||.||||||..|.||.. . . .. ..     .|   
ldyilrellltlllsagearevmhlhytdwpdhgvpqea.llellellld...........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll

MNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
 |. . . | |||.||.|.||| .||.|..... ..| 
tnlyleeaveelraqrpgavqteeqylflyeallellr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 448-712 9.6e-40 131.3 In-house 9-291 (297) alignment 
Range on Protein: 448-712
Range on HMM: 9-291/297.0
SHN--DLDNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESgDGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCL
 ..  ||  ..   |.| || ...   ||||.|.|  ..|||.|    . . |||||.|.     ..  .||  | || .|..|||..|.|.   ||| .
leaekdllldeargesfssakrnsslrknryrdilatddtrvkllrvit.erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv

TKLEENGKKKADVYYPETSQA-QEYGSFWIHLHKK--VMFKDIGVSSLHLYKKgeEFPREVVLLHYTQWPDCGAPPSSSHIRTL--------------SV
.||.|.|..|   |.|.. |  .. |.. .    .    |. . .. |.|. .  .  | |    .  ||| | |     .  .                
aklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmla

MVNTF--------KARGSAKNTNGPVIVHCSAGIGRSGTFISINInMAKIERFGNDPSQMNIsikdsVLELRRQRRGMVQTLDQYIFIFKVI
.|. |        ..  ...  | ...||||||.||||  .  .. .... | .  |    |     .  || ||  .||||.|. ......
lvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdv.ilaklrkkripdvaai.....lsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 469-716 3.4e-39 129.2 In-house 54-283 (290) alignment 
Range on Protein: 469-716
Range on HMM: 54-283/290.0
N-NYGKNRYHDVLPNESTRVRLTpiESGDGDYINANYINGEVPnsyrYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS-QA
| .. ||||.||  |. ||| |   . .||||. |||..|  .     .|  | .| .|. |.|||| .|. ..|| | .| |.|| | . ||||.. ..
ntefkknrykdvvcndktrvilk..dGydGdyvhanyvkGlka....mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

QEYGSFWIHLHKKvMFKDIGVSSLHLYKKGEEFPREVVLLHY--TQWPDCGAPPSsshirTLSVMVNTFkargSAKNTNGPVIVHCSAGIGRSGTFISIN
  .|.. .   ..   ||  .    |  .  .  .| .| |.    |||   . |     ||...   .    . ....|||.|||||||||.|||..|.
ltfGeitvlcsee.ddkdaniikktlsvrdkdsGkehklkhlkikswpdksvals.....tlallrtlr....ilrkasGpvvvhcsaGiGrtGtfvaie

INMaKIERFGNdpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
. . .|   |      .. . | |  ||. | . ||   ||. . ... |. 
vgl.qilldGk.....eldlldlvralrnsrlnsvqvdiqylalveilldlG
0043147 (Phosphotyrosine protein) phosphatases II 496-709 5.8e-39 128.9 In-house 4-154 (172) alignment 
Range on Protein: 496-709
Range on HMM: 4-154/172.0
DGDYINANYINGEVpnSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLeengkkkadvyypetsqaqeygsfwihlhkkvmfkdigvsslhlYKK
. |||||.|... .    . .||.|.||..|. |||||..|.  ..||.||.|                                            .. 
gsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel............................................lyd

GEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFkargsAKNTNGPVIVHCSAGIGRSGTFISININMakierfgndpsqMNISIKDSVLELRRQR
.| . |... ..|. ||| |.|...  ...|. . . .     |.. .|||.||||||.||.||.. . . .            ...|. . | ..|..|
pellerlgiqylylpwpDhgvpllellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylml............lglsleeavalvrekR

RGMVQTLDQYIFIF
.|.||. .||.|. 
pgavqnpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 492-712 1.1e-37 124.8 In-house 7-169 (176) alignment 
Range on Protein: 492-712
Range on HMM: 7-169/176.0
IESGDGDYINANYINGEvpnsyrYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQAQEygsfwihlhkkvmfkdigvsslh
.. .| ||||||.| |       ..||.|.|||.|. ||..|..|.. ...|.||.. | |. | . |.||  ...                        
gldldldyinanlilgs......rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

lykkgeefprevvLLHYTQWPDCGAPPSsSHIRTLSVMVNTFKARGsakntnGPVIVHCSAGIGRSGTFISININMAkierfgndpsQMNISIKDSVLEL
               ... ||| |.|.. ... .|  .....  .|      |||.|||||||||.||.. . . .           ....|. . . ..
.............qylhlpwpDhgvpdl.elllellefirealkeg......gpvlVHCsaGigRtgtlvaayllel..........ekglsveealalv

RRQRR-GMVQTLDQYIFIFKVI
|.||. |.||| .|| |. ...
reqRplgavqtpeQyrflyefe
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 470-711 3.7e-37 122.8 In-house 7-235 (239) alignment 
Range on Protein: 470-711
Range on HMM: 7-235/239.0
NYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINgEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSqaQE
|  |||| ...  . .|| |  .      |||||.|.  .   | . ||| |  .  .  |||||.|.||  ||| || | |  |||.  |.|...   .
nkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sk

YGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfkargSAKNTNGPVIVHCSAGIGRSGTFISININMA
|  . . |.|  .| |  . .. . . |.   | |   |.| ||| | |  .. .  |   .        .     | ..|||||.||.|.|. |.  . 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.....dslpgarpwvihcsagvgrtgaflvidamlr

KIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKV
. ..      |  . | . |  .| .|  |||| .||.||.  
qakk......qktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 470-710 4.2e-37 122.6 In-house 8-235 (239) alignment 
Range on Protein: 470-710
Range on HMM: 8-235/239.0
NYGKNRYHDVLPNESTRVRLTPIES-GDGDYINANYINgEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSqaQE
|  |||| ...  . .|| |  .      |||||.|.  .   | . ||| |  .  .  |||||.|.||  ||| || | |  |||.  |.|...   .
nkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst..sk

YGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfkargSAKNTNGPVIVHCSAGIGRSGTFISININMA
|  . . |.|  .| |  . .. . . |.   | |   |.| ||| | |  .. .  |   .        .     | ..|||||.||.|.|. |.  . 
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitk.....dslpgarpwvihcsagvgrtgaflvidamlr

KIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFK
. ..      |  . | . |  .| .|  |||| .||.||. 
qakk......qktvdifnyvkairedrphmvqtseqyvfihl
subfamily_ptpA1_pd Subfamily ptpA1 469-673 5.3e-37 122.5 In-house 46-259 (418) alignment 
Range on Protein: 469-673
Range on HMM: 46-259/418.0
NNYGKNRYHDVLPNESTRVRLTPIESGDG-DYINANYINGEVPNSyryYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQAQ
 |  |||| ..|| . |||.|  |.  .| ||||||||.|  |.    .|. | ||| || ||||||||.|  .|| |..  || . |.| |.||    .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq...fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

----------EYGSFWIHLHKKVMF--KDIGVSSLHLYKKGEefPREVVLLHYTQWPDCGAPPSSSHIRTLS-VMVNTFKARGSAKNTNGPVIVHCSAGI
           .|.. . | . .    ..|    ..|  .||   |..   .|  |||   |  .  .| |   . |  .    . . | |.|||||||.
qfsiygngnevfgtysvelveviqdpereiitrnirltfege..trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagv

GRSGTFISININMAKIERF
||.||| .  | | |....
grtgtfctavimmkkldhy
0036282 (Phosphotyrosine protein) phosphatases II 497-709 1.2e-36 121.4 In-house 2-163 (174) alignment 
Range on Protein: 497-709
Range on HMM: 2-163/174.0
GDYINANYINGEVPNSyrYYIACQAPLPstikdFWRMVWEERSSVIVCLTKLEENGKKKADVYYPEtsqaqeygsfwihlhkkvmfkdigvsslhlykKG
 |||||..... . ..  ..||.|.||.     ||.|..|......|.|....|.|. |   |.||                                . 
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lr

EEFPREVVLLHYTQWPDCGAPPSSShIRTLSVMVNTFKARgsakNTNGPVIVHCSAGIGRSGTFISININMAKIErfgNDPSQMnisiKDSVLELRRQRR
| . |... ..|. ||| |.|..|  ....   |... ..    . .|||.||||||.||.||.. . . .  ..   ... .      | | |||.|| 
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealse....dpggpvlVHCsaGvgRtGtlvaaylmlrgll...eslvda....ldlvrelRlqrp

GMVQTLDQYIFIF
||||| .||.|. 
gmvqtpsQyrfly
0049260 (Phosphotyrosine protein) phosphatases II 513-709 5.4e-36 118.9 In-house 8-143 (152) alignment 
Range on Protein: 513-709
Range on HMM: 8-143/152.0
YRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYpetsqaqeygsfwihlhkkvmfkdigvsslhlykkgeefprevvLLHYTQWP
 ...||.|.|.| |..|||||..|   ..||.||.|.|.|| | . |.                                              ....||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwp

DCGAPPSSSHIRTLSVMVNTFkargsAKNTNGPVIVHCSAGIGRSGTFISININMakierfgndpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIF
| |.|..| ... |  ... .     |.. .|||.||||||.||.||.. . . .            ...|... |  .|..| |.|.. .|..|..
Dhgvpdlsqlllflllfiekl.....aldkggpvlVHCsaGvgRtgtlvaaylml............lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 460-715 3.1e-33 109.9 In-house 23-258 (267) alignment 
Range on Protein: 460-715
Range on HMM: 23-258/267.0
EKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGdgdYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKadVY
 .    .  .|  .||. |.|| . ||| |   |     |||| |..|   .  . .|. | ||  || ||. .. ... .||| |||  ..  ..  ..
stisqsiaeknqernrlddnlpyddtrvilrtkeee...yinasyvegy..ktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirl..fw

YPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGeEFPREVVLLHYTQWPDCGAppSSSHIRTLSVMVntfkARGSAKNTNGPVIVHCSAGIGRSGT
 |.  ||..|  . .    .   .|  . .| |  |  |  ..|.| .| .|          ... |  ..    |.   .| | |..|.||.|.|||||
PPkmgqakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkwnintn..nkpylkplfgil....aknqlengnrPlvvacsdGvGrsGt

FISINinmAKIERFGNDPsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
|. |.   ...||  ..       | | ....| || |.|.|...||.| ... . 
flvid...sqlerakteg...vsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 469-713 3.9e-33 109.8 In-house 40-274 (307) alignment 
Range on Protein: 469-713
Range on HMM: 40-274/307.0
NNYGKNRYHDVLPNESTRVRLTpIESGDGDYINANYINGEVpnSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPE-TSQAQ
 |  ||||.||   . .|. .. ..    ||| |||.   .    . .|..| || .|. .|| |. .|.   .. | |. | .| |.. |.|    | .
antdknryqdvkcqdkgrivvk.fdglasdyihanylgiai..kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqkl

EYGSFW--I---HLHKKVMFKD---IGVSSLHLYKKGEefPREVVLLHYTQWPDCGAPPSSshirtLsVMVNTFKARgsAKNTNgPVIVHCSAGIGRSGT
 .|.    |    |  | .  |   | |..|..   ..   | .  | ...||| |.|.       |   .| ..|     .|| ||.||||||.|||||
vfgeapntisvanlgakklapdedlinvttlkvdwaqk..srtiqhlqwenwpdrgvpqin.....l.tainlleav..rydtn.pvvvhcsaGvGrsGt

FISININMAKIERfGNDPSQMNisikDSVLELRRQRRGMVQTLDQYIFIFKVIN
 ..| . . |. . | .  .|.    . | ||| ||.  .||  ||... .|. 
ivaislvqdkmia.Ginckdmk....klveelrsqrhyaiqteaqylylhrvll
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 467-715 6.3e-33 108.6 In-house 34-268 (281) alignment 
Range on Protein: 467-715
Range on HMM: 34-268/281.0
QPNNYGKNRYHDVLPNESTRVRLTP--IESGDGDYINANYINGevPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS
|| |  |||| ..   . .||.|     .    ||| ||||    |   | ||  | |   |  |||||.|.| .. || | .. |  ..|.  |.|  .
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirs..pflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

Q-AQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEfpREVVLLHYTQWPDCGAPPSSShirtlsVMVN---TFKARgsakNTngPVIVHCSAGIGRSGTF
. . ..  . .      . | .  . | |  .||   | .    . .|||   | ||       ||..     .||     |  | ..|||||.|||||.
hcclqfdklsvsyedstvnkslvttrlnlsyeget..rlithwlwkewpdwqvpesse......vmlkilrkirar....st..ppvihcsagvgrsgtl

ISININMAKIERFGNDPsqmniSIKDSVLELRRQ-RRGMVQTLDQYIFIFKVINDV
....| .  |      |      ||. |  ||   |   ||||.||..|.||. |.
maveialqsihshftlp.....dikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 456-711 1.1e-31 104.5 In-house 39-285 (310) alignment 
Range on Protein: 456-711
Range on HMM: 39-285/310.0
KHDEEKFFSALQpNNYGKNRYHDVLPNESTRVRLTPIESGDGDYINANYINGEVPNSyrYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKK
| |    . | . ..  |||| ||.  ...||.|.   |  .||| |||.. .   |   .| .| ||  || |||||...||.  |. | |  |.|. |
kqdssltyeayk.kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrs..tficsqgplqhtiidfwrmifqeraesilllckvgeegrpk

ADVYYPETSQAQEYGSFWIHLHK----KVMFKDIGVSSLHLYKKGEEFPR-----EVVLLHYTQWPDCGAPPSSSHirtlsvmvnTFKARGSAKNTNGPV
.  |.|    .. ||   .        .    .. |. .      .| |       | |... .|||.| |    |         |   |  |.   ||.
cvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekch.........tvpqrllaqvrhgpc

IVHCSAGIGRSGTFISININMAKIERfGndpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKV
.||||||..| .. ....... |..| |      .. ... . ||...|   .||  ||..| .|
vvhcsagkdrlyvvvalklkidkldr.g.....lkvdaeevktellksraiciqtelqyliidrv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 455-718 1.5e-31 104.2 In-house 33-289 (305) alignment 
Range on Protein: 455-718
Range on HMM: 33-289/305.0
RKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPieSGDGDYINANYINgeVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKK
|  | ||. .  . .. |||||.||   .  ||.| .  .   .|| |||.    |   . .| .||||  |  ||| | ....   |  | .| | | |
rfndfekmkafkeaqeagknrykdvgcldnnrvkleg..pwpheyihanyvs..tptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgak

KADVYYPETSQA----QEYGS---FWIHLHKKVMFKDI---GVSSLHLYKKGE-EFPREVVLLHYTQWPDCGAPPSSSHIrtLSVMVntfKARgsakNTN
|   |..   .     .| |      .   ... |..     |.   |  .|  |  | |   |. .||| | |..   |  | ..    |||     . 
kcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlai..lelle...kar....psk

GPVIVHCSAGIGRSGTFISININMAKIERfGNdpsQmnISIKD-SVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
||..|||||||||.|. . ..  . ..   |.   .  |   |  .  .| ||   .|| .||.|. .|| . . .
gpivvhcsagigrtgsvvmleyildqlla.gq...i..iedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 470-716 1.5e-31 104.5 In-house 43-271 (288) alignment 
Range on Protein: 470-716
Range on HMM: 43-271/288.0
NYGKNRYHDVLPNESTRVRLTpiesGDGD-YINANYINgevPNSY-RYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPET-SQA
|  ..||...   . |||.|.     | | ||.|| .     . | |  | .|||| .||. .|.|. |.    || |..| | ||.|...|.|    ..
nptrdryenlprcditrvkls....ddpdfyiaanvvs...sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

QEYGSFWIHLHKKV--MFKDIGVSSLHLYKKGEEFPrEVVLLHYTQWPDCGAPPS-SSHIRTLSVMvntfkargsaKNTNGPVIVHCSAGIGRSGTFISI
  .| .     ||   . | . || |.  |.|||    |  ||. .|.| | | .  | .| | |.          |... |..||.|||.||.||.| |
arigrlctvvkkkradidklvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevl..........kslqkPivvhssaGvGrtgtlili

NINMAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
 | .  .       .. ...|.  . .|| .|.  .||  ||....... . |
lialeslr......lddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_egg_pd Subfamily egg 453-718 3e-31 103.2 In-house 23-272 (307) alignment 
Range on Protein: 453-718
Range on HMM: 23-272/307.0
DNRKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTpIESG--DGDYINANYINGEvPnSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEE
 .   ||. .  |.. ||  | | . |  ..|.||.|  .. |   .|.| ||...|. |  .  .| .||||  | .||||||..|.   || ||   |
leesvdeislttaasdnnlekarskrvhckdssrvkle.lrrGqylddfihanrvkGk.p.llnefilaqaplkntvddfwrmvfqeevqyivmltsrke

NgkKKADVYYPETS-QAQEY--GSFWIHLHKKVMFKDIGVSSLHLYKKGEEfpREVVLLHYTQWpdcgappsssHIRTLSVMVNTFKARGSAKNTNGPVI
.  .. . |.| .  ..  .  ||. |.  |     |      .|   | .  .|   | . |.           .. .| .   ..    ..|   ||.
s..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqg..........dvnnssdvysplrvlrklrnlskpvv

VHCSAGIGRSGTFISININMAKIERfGndPSqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTD
|..  |. ...|...|.| . .. | |  |  .   .. .|  ||..||  |..  .|.|.....  .. |
vqdilGvskaatlvaieiallsllr.G..pi.tkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 467-713 3.8e-30 99.6 In-house 50-286 (305) alignment 
Range on Protein: 467-713
Range on HMM: 50-286/305.0
QPN--NYGKNRYHDVLPNESTRVRLTPIEsgDGDYINANYINGEVPNSYRyYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS
| .  .  ||||.||  .. . |.|        ||| |||.   .    | .|..| ||  || .|| || ...   || | |  | || |.  |.| . 
qsadiaitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekr.ficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

QAQE-YGSF-WI-H-LHKKVMFKD--IGVSSLHLYKKGEEfPREVVLLHYTQWPDCGAPPSSshIRTLSVMVntfKARGSakntNGPVIVHCSAGIGRSG
  .    |   .      | | .|  | .. |.|   |..    |  |..|.||| | ||    . .| ..      |||    . |..|||||||||.|
geklelksgivvenvsgskpmerdaeiqitllnltysgdq.kmsvrhlqwtewpdrgvppck..ltslells...airgs....kvpivvhcsagigrtg

TFISININMAKIERFGNDPsqmniSIKDSVLELRRQRRGMVQTLDQYIFIFKVIN
| ..|.  . ||    . |      . . |  || ||   .|.  ||.|| .|. 
tivaieyilekiaenkpcp.....pmpelvkalrdqrafsiqndvqylfihrvml
PTPc_DSPc_SM00012 603-713 4.5e-30 99.3 In-house 2-104 (105) alignment 
Range on Protein: 603-713
Range on HMM: 2-104/105.0
VVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARGSAkntNGPVIVHCSAGIGRSGTFISININMAKIERFGndpsqMNISIKDSVLELRRQRRGMVQTL
|  .|||.|||.|.| .|..| .|   |...|   .    ..||.||||||.||.|||. . | . ..|.        ...|.. | |||.||.|||||.
vkhyhytgwpdhgvPeesdsilellravkknknkses...skpvvVhCsaGvgRtgtfvaldillqqleket.....kevdifqivkelrkqRpgmvqte

DQYIFIFKVIN
.||.|. ....
eqylflyrall
subfamily_CG42327_pd Subfamily CG42327 470-626 2e-29 97.3 In-house 28-186 (319) alignment 
Range on Protein: 470-626
Range on HMM: 28-186/319.0
NYGKNRYHDVLPNESTRVRLTPIESGDGD-YINANYINGEvPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS---Q
   |.|. .|.|   ||| |  | . | | |..|.|. |   ..  .|||.|..| ..  ||||.||| .| |||.||.| |.| |.   |.|      .
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGy.ddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

AQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYtQWPDCGAPPSSSHIRTL
 . || . . | ..   .   .|.| | .  .|  ||.    | .|.... | . . . ..
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam
0044763 (Phosphotyrosine protein) phosphatases II 490-711 3e-29 97.3 In-house 10-166 (178) alignment 
Range on Protein: 490-711
Range on HMM: 10-166/178.0
TPIES-GDGDYINANYINGEvpnsyrYYIACQAPlpstiKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQaqeygsfwihlhkkvmfkdigvs
...|    .|||||..| .       .|.... |      |......|.  ..||.||.  |.|. | | |.||                          
snleglersdyinaseilpg......lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.......................

slhlykkgeefprevVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsaKNTNGPVIVHCSAGIGRSGTFISININMAKierfgndpsqmNISIKDSV
               .  ... .|| |.|....|.. .  .....      .. .|||.||||||.|||||.. . . .             ..|. . .
...............iqylhipipDhgvpdllehflefvefieeal.....dekggpvlVHCsaGvgRsgtlvaaylmkkl...........glsleeai

LELRRQRRgMVQTLDQYIFIFKV
 ..|..|. .|.. .|. .. ..
elvrerRp.ivpnpgqlrqLyef
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 470-719 3.5e-28 93.4 In-house 35-273 (285) alignment 
Range on Protein: 470-719
Range on HMM: 35-273/285.0
NYGKNRYHDVLPNESTRVRLtpiESGDGDYINANYINGEVpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPET-SQAQE
|   ||| ||   | ||| |   .  | ||| |...     .    ||. | ||| |. |||.|...|. . .. |  | | | .|. .||||   .  .
npdlnryadvrcieetrvvl...knhdrdyihaswmrmpg.kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGSFWIHLHK--KVMFKDIGVSSLHLYKkGEEFPREVVLLHYTQ---WPDCGAPPSSshiRtlsVMVNTFKARGSAKNTNGPVIVHCSAGIGRSGTFISI
.| . | | .  .       . .| . .  |.   | . . . |   |||  ||  .   |    |.. .|     .  . |. ||||||.||. ||. |
fgkyeitlteckeeaiagtilnaltvin.tedasseplymnhvqvpwwpdqlapeda...r...pmielykwvkkvnpkekpicvhcsagvgrtatfvgi

NInmAKIERFGNdPsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTDM
.   | |  . | |   || . | | |.|  |   ||.  |..|.. |. . .   
dy..atirimen.p...niemldivremramrfqavqshmqflflyvvlmeyfige
0051082 (Phosphotyrosine protein) phosphatases II 498-711 3.9e-28 93.3 In-house 4-148 (151) alignment 
Range on Protein: 498-711
Range on HMM: 4-148/151.0
DYINANYINGEvpnsyryYIACQAPLPstikDFWRMVWEERSSVIVCLTKLEENGkkKADVYYPETSqaqeygsfwihlhkkvmfkdigvsslhlykkge
||||..|. |        ......||.    ||.....|.  ..||.|...||.|  .   |.||..                                 
dyinfsyvtgg.......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

efpREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfkargsakNTNGPVIVHCSAGIGRSGTFISININMAKierfgndpsqmnISIKDSVLELRRQRRG
   .||. .... ||| | | |   .. .  ...         . ||||.||||||.||.||.. . . . .            .|. . . |.|..| |
...ievlhipildwpdpglplsfdavleflellld........kkngpvlvHCsaGkgRTGtlvalylmllg............vsleealeeyrlkrpg

MVQTLDQYIFIFKV
.||. .|..|....
vvqpnqqflfqlfa
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 472-706 1.2e-27 91.5 In-house 52-271 (301) alignment 
Range on Protein: 472-706
Range on HMM: 52-271/301.0
GKNRYHDVLPNESTRVRLtpIESGDGDYINANYINGEvpNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPE-TSQAQEYG
 |.||  |  . || |..  |. |    | ||.|. .     . .|| |.||..| .||| |.       || |..  |. ..| . |.|  .|.  . |
dkhryptvPckPstavev..ivdGkrvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

SFWIHLH--KKVMFKDIGVSSLHLYKKGEEFP-REVVLLHYTQWPDCGAPpsSSHIRTLSVMvntfkarGSAKNTNGPVIVHCSAGIGRSGTFISININM
 | |...  .... |.|   .|..    ..|. | |.   |..|.| | |   ||. .  .|         .|... |..|||||||||| .||. ..  
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvP..kshaelfdlm.......elvkksekPivvhcsaGiGrsvafigteyla

AKIErfgNDPsqmNISIKDSVLELRRQRRGMVQTLDQYI
 ..|   .||   .| ..... .|| .|   |||  |  
reve...adp...tieltealkhlrehrwngvqtnsqly
0048076 (Phosphotyrosine protein) phosphatases II 570-712 1e-23 79.0 In-house 14-139 (145) alignment 
Range on Protein: 570-712
Range on HMM: 14-139/145.0
GSFWiHLHKKVMFKDIGVSS-LHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKARgsakntNGPVIVHCSAGIGRSGTFISININMA
||.. . ..  ..|| |.   | |    | . |... ..|. |||.|.|.........  ..... ..      .|||.||||||.||.||.. . . . 
gslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke......ggpvlVHCsaGvgRtgtlvaaylmll

kierfgndpsqMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVI
           ...|. . . ..|.||.|.|.. .|..|.....
...........lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 470-565 1.5e-22 74.8 In-house 47-155 (350) alignment 
Range on Protein: 470-565
Range on HMM: 47-155/350.0
NYGKNRYHDVLPNESTRVRLT-PIES--------GDGDYINANYINGEVP---NSYRY-YIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKA
 . ||||...|| | .||.|   ..|           |||||||.. ...       . ||| |||||||..||.... .    ||. ||.. |.. .| 
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

DVYYPETSQ
. |..| | 
yrYWqegsy
0048179 (Phosphotyrosine protein) phosphatases II 596-710 2.1e-21 71.6 In-house 42-139 (144) alignment 
Range on Protein: 596-710
Range on HMM: 42-139/144.0
GEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsaknTNGPVIVHCSAGIGRSGTFISININMakierfgndpsQMNISIKDSVLELRRQR
 |.. ||.. .... ||| |.|.........  ..... .       .|||.||||||.||.||.. . . .            ...|... . ..|..|
pefleregiqylhlpwpDhgvpdllellleflefieeale......eggpvlVHCsaGvgRtgtlvaaylmk...........klglsleealalvrsrr

RGMVQTLDQYIFIFK
 |.|.. .|..|. .
pgavpnpgqlrfLle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 446-712 2.4e-21 70.5 In-house 29-281 (302) alignment 
Range on Protein: 446-712
Range on HMM: 29-281/302.0
HYSHNDLDNRKHDEEKfFSALQpNNYGKNRYHDVLPNESTRVRLtpiESGDGDYINANYINgeVPNSYRYYIACQAPLPSTI---KDFWRMVWEERSSVI
.  .. .|. | | ||  .| . .|  ||. .||   .|..|.|   |    .|.||  ..  ||.  |  |  | |  ..     .|||||..|.   .
kkefkkidtmkvdlek.Ckafk.knlkknqsedvpildsnlvkl...eaepdsyvnaskve..vPeltrsiilaQlpkvdsedsveeFWrmvfqekivsv

VCLTKLEENGKkKADVYYPETS-QAQEYGSFWIHLHKkVMFKDIGVSSLHLYKKGEEFPREVV--LLHYTQWPDCGAPPSSSHIRTLSVMVntFKargSA
| | . ||  |   . ..|..| . .|||....   | |  ..  .. . .    |..   |.  . . |.|..   | . ... .  . |  |.   . 
vilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fa...kk

KNTNGPVIVHCSAGIGRSGTFISININMAKIERFgNDPsqmniSIKDSVLELRRQRRGMVQTLDQYIFIFKVI
 ... ....    |.|| |.|..  . . |...  ..|      ||. |  .| ||  .|..|.||.... ..
ikadentvivSknGaGRagafltlavaveklqkg.kep.....nikeivksiRsqRpravdslkQyvslyial
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 513-711 6.8e-21 69.3 In-house 3-198 (198) alignment 
Range on Protein: 513-711
Range on HMM: 3-198/198.0
YRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPET-SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFP--REVVLLHYT
 | |||.| ||  |. |||.||||  |  || .   . | .    .|.| | | . .|||. .  .  .   |  ...| | ..    |  ||.    .|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

QWPDCGAPPSSSHIRTLSVMVNTfkARGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIF
 | .  .|  .  .  .    .   ..   .. . ||||||| | | .| |....| .   |          . . .    ||. | |.. .|..| ||.
swkekttpnvalfvgfvvasrev..skkyeqekdapvivhcsdgqgftgvfvaldigvrshee....sktsvvdlfevakrlrqarcgiisslqhynfiy

KV
.|
qv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 513-711 7.1e-21 69.3 In-house 4-199 (199) alignment 
Range on Protein: 513-711
Range on HMM: 4-199/199.0
YRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPET-SQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKKGEEFP--REVVLLHYT
 | |||.| ||  |. |||.||||  |  || .   . | .    .|.| | | . .|||. .  .  .   |  ...| | ..    |  ||.    .|
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

QWPDCGAPPSSSHIRTLSVMVNTfkARGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIF
 | .  .|  .  .  .    .   ..   .. . ||||||| | | .| |....| .   |          . . .    ||. | |.. .|..| ||.
swkekttpnvalfvgfvvasrev..skkyeqekdapvivhcsdgqgftgvfvaldigvrshee....sktsvvdlfevakrlrqarcgiisslqhynfiy

KV
.|
qv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 497-716 1.3e-18 62.1 In-house 46-259 (290) alignment 
Range on Protein: 497-716
Range on HMM: 46-259/290.0
GDYINANYINgeVPNSYRyYIACQAPL-------PSTIKDFWRMVWEERSSVIVCLTKLEENGKKKAD----VYYPETSQ-AQEYGSFWIHLHKKVMFKD
 ||| ||..   .||  |  |. |.|.        |||..|| |. .|..  .| | . ||. ... .     |.||.      .. . ..  .|.  .|
ddyiHAnrvt..cpnglr.liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

IGVSSLHL-YKKGEEFprEVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKArgsakntngPVIVHCSAGIGRSGTFISININMAKIERfgndpSQMNIS
. .  | . . ..|||   |    . .| .. .....  . .|  .|.. |.         ||||||  || || .. .|.. . ||       .. ...
vetRelvvkfddeeef..tvtHsllkgWnklnvqedtktllsliqkvkaskt.........pvivHcvdGiSrsAalaaiilgyQkiae.....tsgsvk

IKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
..| . .||.||  ....  .. |.  .|   .
ledvlkalrkqralaitsalelafvdagivlla
subfamily_eak_pd Subfamily eak 469-717 2.3e-18 60.7 In-house 51-306 (332) alignment 
Range on Protein: 469-717
Range on HMM: 51-306/332.0
NNYGKNrYHDVLPNESTRVRLTPIESGDGDYINANYIngEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS-QAQ
..  .|   ...|..   ||||.       ||||  .  | ..  | ||   ..  . .  ||.|| |..|  || | .  |.. .| | |.|. . .  
eavnrn.vvkivpydrylvrltssqlnrlGyinasla..efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

EYGSFWIHLHKKvMFKDIGVSSLHLYKKGEEFPReVVLLHYTQWPDCGAPPSSSHIRTLSV----------------MVNTFKARGSAKNTNGPVIvHCS
..| . ..  .  . ..|    |   .||.|  | |   ..  | .   |     .    |                .  |.|    .  .. |.|  ..
kfGildverkef.vkrniletrllelskGnethr.vlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapii.qsa

AGIGRSGTFISININMAKIErfgnDPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLT
 |  |.|.|. |.. .  |.    .  .   |..| .|  . .|   | .  |. ||.... | | 
rGsaraGvfvvidllirlid....nkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 600-712 5.6e-18 59.8 In-house 214-340 (350) alignment 
Range on Protein: 600-712
Range on HMM: 214-340/350.0
PREVVLLHYTQWPDCGA--PPsSSHIRTLS---VMVNTFKARGSAKNTNG-PVIVHCSAGIGRSGTFISININMAKIERFGN---D------PSQMNISI
| .|  |.. .|.| .    |  | ...|     ....  |.   .| .. |..||||||.|| ||.....  . ..| . |   .      .....  |
PyvvyqlqvknWkDlslllnP.esilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

KDSVLELRRQRRGMVQTLDQYIFIFKVI
.  |.|||.||  |||.|||.|||.. .
siivnelrkqrismvqnldqfifiYeal
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 474-721 1.5e-17 58.3 In-house 47-281 (312) alignment 
Range on Protein: 474-721
Range on HMM: 47-281/312.0
NRYHDVLPNESTRVRLTpieSGDGDYINANYINgeVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETSQAQEYGSFW
||| ..   .  |  |.     .  || ||...  .      ....|.|| .|.  ||...    |. |. |. . |.| .|.  |  .     .     
nrypniqcwdrgrftla...gdenfyihanfvk..ictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

IHLHK------KVMFKD-IGVSSLHLYKKGEefPREVVLLHY--TQWPDCGAPPSSSHIRTLSVMVntfkargsaKNTNGPVIVHCSAGIGRSGTFISIN
..             || |    |..  |     .|  | ||  . ||| | | |      |   |         |. . ||| |||||.||.||.. |.
vyteycteieiggkskdkithrvlkvvvkat..gqesklnhyqwaswpdhgmpdscdtalrllsav.........kkdkkpviahcsagvgrtgtlalie

INMAKIErfgnDPSQMNisIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVLTDMGI
  .| .      | . |  .||| . ||..|   |... ||.. .... ..|   |.
smiaalr....hprkqn..vkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 521-716 2.9e-17 57.1 In-house 98-288 (302) alignment 
Range on Protein: 521-716
Range on HMM: 98-288/302.0
APLPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYPETS-QAQEYGSFWI---HLHKKV-MFK---DIGVSS--LHLYKKGEEFPREVVLLHYTQ
 |  ||.. .| .. . . ...| |... |...||   || .   .  ..| . .    .....  |    .. . .  .. .|| .. .. | .|... 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDCGAPPSSSHIRTLSVMVNTFKargsaKNtngpVIVHCSAGIGRSGTFISININMAKIERfgndpsQMNISIKDSVLELRRQRRGMVQTLDQYIFIFK
||| |||  . .   .    ...|     ||    |.||||||.||.||...|   .    .      .    . . || .|. | | ||. .| |... 
wpdhGapkeaytaldilkfcesyk.....kn....vlvhcsaGvGrtGtlvaikyGiqlcsk......kkvtdllsivlpvrqcryGavqdeqqliylll

VINDVL
..   |
cvtkgl
subfamily_CG42327_pd Subfamily CG42327 633-713 2.5e-16 54.2 In-house 237-312 (319) alignment 
Range on Protein: 633-713
Range on HMM: 237-312/319.0
FKARGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIN
  .| . .. .||..|||| |.||.|. |. .|.. ..|      |.  . | . |  .||.|   |.| .|| ||.||. 
issrsgtresqGPlvvhcsdGvGrtGlviasdiairslee.....skrsvdiPqlvssvrrdrasavltkeqyefiykvls
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 470-565 4.1e-16 53.2 In-house 48-158 (349) alignment 
Range on Protein: 470-565
Range on HMM: 48-158/349.0
NYGKNRYHDVLPNESTRVRLTP-------IE-------SG-DGDYINANYINGEVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENGKK
 . ||||.|.|| | .||.|         |.       ||   |||||||..    .  . ||| |||||||..||....  ..  ... |.. .|.. .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsle

KADVYYPETSQ
| |.|. | | 
kcdiywqelsy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 523-715 1.1e-15 52.4 In-house 39-220 (255) alignment 
Range on Protein: 523-715
Range on HMM: 39-220/255.0
LpsTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYP-ETSQAQEYGSFWIHLH---KKVMFKDIGVSSLHLYKKGeefPREVVLLHYTQWPDCGAPP
|  |.. |....   ...|.| |. ..|.|..| . |.| |  . . .    .       .|... . . |    ||     ..|   .|. |..  || 
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkk...thtvkhysykGWieknaPe

SSSHIRtlsvmvNTFKArgsAKNTnGPVIVHCSAGIGRSGTFISININMAKIERFGNDPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
 .  |.      | .|.   ....  .|.||||.||||| .|. ...   |. |  .  .  ..  .  . ||| .|.. ..|  |  | . .. |.
lareil......nilkv...vrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 455-621 1.6e-14 48.2 In-house 81-240 (244) alignment 
Range on Protein: 455-621
Range on HMM: 81-240/244.0
RKHDEEKFFSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDgDYINANYInGEVPNSyRYYIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEENgkk
 . |   .  |..|||  |||    || .  || |.    |.  |||| .. | .  .   ||  | ||  |  |||.|. |    |.| |  .||.   
irpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgn.tyinasfv.gclgrt.aeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee...

kaDVYYPETSQAQEYG-SFWIHLHKKVMFKDIGVSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSS
  | |.|..   . |     . |  .  ||.|  | | .    .|  . . ..  ..||  |. |   
..deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpndh
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 599-711 4.1e-13 43.4 In-house 216-339 (349) alignment 
Range on Protein: 599-711
Range on HMM: 216-339/349.0
FPREVVLLHYTQWPDCGAP-PSSSHIRTLSV---MVNTFKARGSAKNTNG-PVIVHCSAGIGRSGTFISININMAKIERFGNDPSQMNIS------IKDS
 | |.. | .  |.| .      | ...| |   ....  ||   .. .  ...|||||| ||.|... ... .. .|   |.  ....       |  .
kPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisii

VLELRRQRRGMVQTLDQYIFIFKV
| |||.||  ||| | |.|.|.. 
vnelrkqrismvqnlaqfiaiyea
subfamily_hpo-7_pd Subfamily hpo-7 523-716 6e-13 43.3 In-house 43-227 (263) alignment 
Range on Protein: 523-716
Range on HMM: 43-227/263.0
LPSTIKDFWRMVWEERSSVIVCLTKLEENGKKKADVYYP-ETSQAQEYGSFWIHLHKKVMfkDIGVSSLHLYKKGE--EFPREVVLLHYTQWPDCGAPPS
|  ||. |....   ...|.| |.  .|.|..| . |.| |  . | .    .   | .   |. . .|.| .  .     ..|    |. |..  .|  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

SSHIRTLsvmvntFKA-RGSaKntngPVIVHCSAGIGRSGTFISININMAKIERFGNDPSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDVL
.  |. .      .|. |.| |    ...||||.|||||  |  ...   |. |  .  |  ..     . ||| .|.. ..|  |  | . .. |..
areilni......lkvarns.k....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 602-714 1.5e-12 41.6 In-house 90-192 (440) alignment 
Range on Protein: 602-714
Range on HMM: 90-192/440.0
EVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTfkarGSAKNTNGPVIVHCSAGIGRSGTFISININMAKIERfgndPSQmnISIKDSVLELRRQRRGMVQT
 .   ||  ||| | |  .. .  .   ||        |  |||..|||||| ||.|  |...  . . .|      |  | |   .  .| .|  ||||
tlkqyhyqgwpdkgvpkfagpvlkmiqdvne....sqekagngpllvhcsagagrtgviiavdsilreakr....sdq..idifsfinsmrnnrpqmvqt

LDQYIFIFKVIND
 .|| |..... .
peqyafvheavle
0038934 (Phosphotyrosine protein) phosphatases II 587-715 5.4e-12 41.2 In-house 63-176 (194) alignment 
Range on Protein: 587-715
Range on HMM: 63-176/194.0
VSSLHLYKKGEEFPREVVLLHYTQWPDCGAPPSSSHIRTLSVMVNTFKargsAKNTNGPVIVHCSAGIGRSGTFISINInmakIERfgndpsqMNISIKD
..  . |   |||..  .  .  ..|| |..|| . ...   .|..|     .....| | ||| ||.||.||..   .    |.|       ...| ..
ltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl....nedpggvvaVHCkaGlgRtGtlvaaYL....iyr.......lgmsaee

SVLELRRQRRGMVQTLDQYIFIFKVINDV
..  .|. |.|.... |..  ..|  ...
AialfrekRpgaipnqdyleallkrykel
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 463-545 2.5e-11 37.7 In-house 30-116 (347) alignment 
Range on Protein: 463-545
Range on HMM: 30-116/347.0
FSALQPNNYGKNRYHDVLPNESTRVRLTPIESGDG------DYINANYINgeVPNSYRYYIACQAPLPSTIKDFWRMVWEERSSVIVCL
 |.   ..  ||| .||  ...||| |.| .|  .       |||| .|.    |. . ||  | |||.|..|||.||   . . .| .
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashik..fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 647-714 5.6e-10 33.5 In-house 2-63 (69) alignment 
Range on Protein: 647-714
Range on HMM: 2-63/69.0
IVHCSAGIGRSGTFISININMAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVIND
.||||.| ||.||||.| ..||.|       |.  . | . |  .|. |  ||    .||||   . .
vvhcssgtgrtgtfiaimvemarik......seklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 647-715 1e-09 32.6 In-house 1-63 (69) alignment 
Range on Protein: 647-715
Range on HMM: 1-63/69.0
IVHCSAGIGRSGTFISININMAKIErfgndpSQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
.||||.| ||.||||.| ..||.|       |.  . | . |  .|. |  ||   ..|.||   . . 
vvhcssGtGrtGtfiaimvemarik......seklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 469-557 3.9e-09 30.4 In-house 33-119 (332) alignment 
Range on Protein: 469-557
Range on HMM: 33-119/332.0
NNYGKNRYHDVLPNESTRVRLTPIEsGDGDYINANYINGEVPNSyrYYIACQAPLPS-TIKDFWRMVWEERSSVIVCLTKLEENGKKKAD
||   ||   .   . .|| |.| . |  |. ||....|   .|   || .|||.   |   ||||| | . |.|. .  ..|. |.|| 
nnmdmnriphlycfdhsrvelapqd.gkddfynaswvdgyskks..ayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap
PTEN_1 607-661 6.5e-09 30.9 In-house 98-148 (196) alignment 
Range on Protein: 607-661
Range on HMM: 98-148/196.0
HYTQWPDCGAPPSSSHIRTLSVMVNTFKARGSakntNGPVIVHCSAGIGRSGTFI
.   ..|.|||. |.... . .. .  ... .    .. |.||| ||.||||| .
lhfpieDhgapslselfdicksfiewllsdpn....gnvVlVHCkaGlgRsGtvv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 516-595 1.3e-08 28.6 In-house 238-314 (440) alignment 
Range on Protein: 516-595
Range on HMM: 238-314/440.0
YIACQAPLPSTIKDFWRMVWEERSSVIVCLTKLEEngkKKADVYYPETSQAQEYGSFWIHLHKKVMFKDIGVSSLHLYKK
.|| | || ||. ||||.| . | | |. | .|..   |   .|.|  ...  .| | .  .    .. . | .| |  |
fiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkyk
0048567 (Phosphotyrosine protein) phosphatases II 601-662 1.5e-06 22.7 In-house 35-96 (157) alignment 
Range on Protein: 601-662
Range on HMM: 35-96/157.0
REVVLLHYTQWPDCGaPPSSSHIRTLSVMVNTFKarGSAKNTNGPVIVHCSAGI---GRSGTFIS
 .  |.... . | | |.. ...  . ...| |   .. ........|||.||    ||..|.|.
iddglvyedfffdfG.PlnlailyrFilklnkfl..kilelagkaiavhckaglkkrgrtatLig
PTPc_motif_SM00404 638-661 2.6e-06 22.4 In-house 75-98 (140) alignment 
Range on Protein: 638-661
Range on HMM: 75-98/140.0
SAKNTNGPVIVHCSAGIGRSGTFI
.|....| |.||| ||. ||.|.|
naekkggkvlVHCqaGvSRSatli
subfamily_DSP23_pd Subfamily DSP23 629-710 3e-06 22.0 In-house 70-140 (148) alignment 
Range on Protein: 629-710
Range on HMM: 70-140/148.0
MVNTFKARGSAKNTNGPVIVHCSAGIGRSGTFISINInmAKIErfgndpsqmNISIKDSVLELRRQRRGMVQTLDQYIFIFK
.|.  .    |.. |  | |||  | ||.||...  .   | .         ...  ... |.||.| | |.|..|   ...
vvefvrvveeaeekneavsvhcllgrgrtgtmlacyl..vker.........klaaaeaiaevrrlrpgsvetveqeklvrd
DSPc Dual specificity phosphatase, catalytic domain 638-661 3.7e-06 21.8 Pfam-A 68-91 (133) alignment 
Range on Protein: 638-661
Range on HMM: 68-91/133.0
SAKNTNGPVIVHCSAGIGRSGTFI
.|.. .. |.||| ||| ||.|.|
kaeqkgkkvlVHCqaGisRSatli
DSPc Dual specificity phosphatase, catalytic domain 638-661 3.7e-06 21.8 In-house 68-91 (133) alignment 
Range on Protein: 638-661
Range on HMM: 68-91/133.0
SAKNTNGPVIVHCSAGIGRSGTFI
.|.. .. |.||| ||| ||.|.|
kaeqkgkkvlVHCqaGisRSatli
subfamily_ptpA1_pd Subfamily ptpA1 678-715 6e-06 20.2 In-house 360-397 (418) alignment 
Range on Protein: 678-715
Range on HMM: 360-397/418.0
SQMNISIKDSVLELRRQRRGMVQTLDQYIFIFKVINDV
|.... .   ||.|| || |||| |.||.| .| | | 
sridfnlfsivlklreqrpgmvqqleqylfcyktilde