Gene DDB_G0281427 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily FIG4
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP049_AA protein Get Run
DdisP049_AA_302-676 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_FIG4_pd Subfamily FIG4 77-710 5.8e-268 880.9 In-house 2-568 (569) alignment 
Range on Protein: 77-710
Range on HMM: 2-568/569.0
VLYETKTRFYLVGSNRTKNRFKVLKIDRTYEEEVMISEDPTDYNKQQIQDLLTMIGNANREGLTRVCSAYGILGFIRFLHGYYIILITKKRKVGMIGTHF
||||||.|.||||||.....|.|||||||.|.|....|| ....|..|..||... .|||.||....||||||||.|||.|||.||.||..||..||.|.
vlyetkarlylvGsnkretkfrvlkidrtverelvvledkveftkneikellasleeanrdglekkvsayGilGfvrflegyylilvtkrkkvaviGgha

IYGIDDITYVYIPPSFPKtnSPEFADETRYKGLFLSLDLTKDFYFSYTYDITRTLQYNMTryfhspipknipqtNNNSNNNNNNNTNTNTNEINKKKLYY
|| |.||....|. .. |  |....||.||. || ..||||.|||||.||.|||||.|..              ...||.............|..|||..
iykiedialikitedskk..sekssdearylklfkdvdltknfyfsysydltrtlqtnll..............lsdsnrekekaedrvditieakklda

NDQFTWNHFLLECLVDQVKTWYWVLPIIHGYFVQDKIDIFGKGLDLILIARRSRYYAGARFLKRGINENGQVANDVETEQILQEPLTGWSSKAKFSSFVQ
|..|.||.||||.| |.|||..|.| ||||.. |.||...|| ....||||||...|||||||||.|..|.|||.||||||..|. .|.......|||||
nekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqivheasegsldsdryssfvq

IRGSIPLYWEQDNNIMTPKPPIKIQRMDPFLGSTILHFQDLFQRFGSPIIILNLVKSNEKKPRESILRNEFTDCINCLNEMLPEQHRIHYQAWDFHQAAK
.|||.||||.||.. ...||||||...|||. ...|||.|||||.|||||||||||..||..|||||..||...|..|||.|||.....|..||...|.|
lrGsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylneflPeekklkyiswdmarask

SKDEDHMAWLDSFANQSILKTGIFYSSSKLYCNFlrenynsssddnggsttttttttaattisglnekenelfsylfneigtEQIGVVRTNCIDSLDRTN
||.|.....|...|..|. |||||.|...|..                                                   | |.|||||.|.|||||
skeenvlevlekyaeksvkktGiflsapdlestk................................................iqeGivrtnCvdcldrtn

AAQFCIGKCALGYQLYSMGLLDSPSLDFNTGIVQVLIDMYEACGNQIALQYGGSELANTIKTYTK-HSLSSQSRDLVNAIKRYISNSFIDADKQHSINLF
||||.|||.||||||.|.|..|...|.|.. .|..|...||..|...|||||||.|.||||||.| ...||.|||.....|||.||||.|||||..||||
aaqfvigkvalgyqlkslGiidesklefdsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlf

LGYFVPAKQIAiekiPLWNLETDHYLHNITNRKQH
||...| ...     .||.||||.||||....|..
lGvyspreglp....slWeletdfylhnayslklp
Syja_N SacI homology domain 145-479 1.7e-90 294.4 Pfam-A 1-316 (319) alignment 
Range on Protein: 145-479
Range on HMM: 1-316/319.0
AYGILGFIRFLHGYYIILITKKRKVGMIG-THFIYGIDDITYVYIPPSFPKTNS------PEFADETRYKGLFLSLDLTKDFYFSYTYDITRTLQYNMTR
||||||.||.|...|...|||..||..|. .| || |...  . .. .  ...        | ..|...  |. .|. .. |||||.||.||.|| ....
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

YFHSPIPKN--IpqtnnnsnnnnnnntntntneinKKKLYYNDQFTWNHFLLECLvDQVK--TWYWVLPIIHGYFVQDKIDIF-GKGLDLILIARRSRYY
  ...  ..                          .    ....|.||..||. |  ..|  .  |.||.|.|.. | .| .  .| ..|.||.|||...
eeeekeeesksl.......................pllkevderFvWNrnllkpl.ielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkr

AGARFLKRGINENGQVANDVETEQILQEpltGWSSKAKFSSFVQIRGSIPLYWEQdNNIMTPKPPIKIQ-RMDPFLGSTILHFQDLFQRFgSPIIILNLV
||.|.|.|||...|.|||.||||||..|    .. . .. ||||||||.||.||| .. ...||.|||.  ...    . .||..|..|. ..|...||.
aGtRylrRGidddGnvANfvEtEqivse...kkeeskrvfSfvqiRGSvPlfWeq.asnlslkpkikitrsseasqkafkkHfkklikrY.gkivvvnLl

ksnEKKPRESILRNEFTDCINCLNEMLPEQHRIHYQAWDFHQAAKSKD
   |||.||. | ......||.||. |.|.....| ..|||.. |.| 
...ekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkk
Syja_N SacI homology domain 145-479 1.7e-90 294.4 In-house 1-316 (319) alignment 
Range on Protein: 145-479
Range on HMM: 1-316/319.0
AYGILGFIRFLHGYYIILITKKRKVGMIG-THFIYGIDDITYVYIPPSFPKTNS------PEFADETRYKGLFLSLDLTKDFYFSYTYDITRTLQYNMTR
||||||.||.|...|...|||..||..|. .| || |...  . .. .  ...        | ..|...  |. .|. .. |||||.||.||.|| ....
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

YFHSPIPKN--IpqtnnnsnnnnnnntntntneinKKKLYYNDQFTWNHFLLECLvDQVK--TWYWVLPIIHGYFVQDKIDIF-GKGLDLILIARRSRYY
  ...  ..                          .    ....|.||..||. |  ..|  .  |.||.|.|.. | .| .  .| ..|.||.|||...
eeeekeeesksl.......................pllkevderFvWNrnllkpl.ielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkr

AGARFLKRGINENGQVANDVETEQILQEpltGWSSKAKFSSFVQIRGSIPLYWEQdNNIMTPKPPIKIQ-RMDPFLGSTILHFQDLFQRFgSPIIILNLV
||.|.|.|||...|.|||.||||||..|    .. . .. ||||||||.||.||| .. ...||.|||.  ...    . .||..|..|. ..|...||.
aGtRylrRGidddGnvANfvEtEqivse...kkeeskrvfSfvqiRGSvPlfWeq.asnlslkpkikitrsseasqkafkkHfkklikrY.gkivvvnLl

ksnEKKPRESILRNEFTDCINCLNEMLPEQHRIHYQAWDFHQAAKSKD
   |||.||. | ......||.||. |.|.....| ..|||.. |.| 
...ekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkk
Sac_COG5329 76-502 1.9e-65 212.7 In-house 3-390 (1070) alignment 
Range on Protein: 76-502
Range on HMM: 3-390/1070.0
FVLYETKTRFYLVGSNRTKNRFKVLkidRTYEEEVMISEDPTDYNKQQIQDLLTMIGNAnregltrvCSAYGILGFIRFLHGYYIILITKKRKV-GMIGT
 .|.|.||| . ..||  .  |. |      ..|. .....  . .. ..  .  . .|           ||.||.| .   ...|.||.| || ..|. 
illsekktRsiaivsnkyalvfrrl...svknselsvcaaelvavselkkegfrslssa........heiygvlGlielegslflivitgkskvaqvipg

HFIYGIDDITYVYIPPSfpKTNSPE--FaDETRYKGL--------FLSLDLTKDFYFSYTYDITRTLQYNmTRYFHSPIPK-NIPQTNNNSNNNNNNNTn
. || |...  . .  .  |    |    || ... |        .  |. .. ||||...||| ||| . ..  ...  .  . .   ||. ...  . 
etiykilavdfislnnn..kwddeeies.deasteklrsehpcselkkLlsngsFYfStdfditntLqkr.lkeelelsvdtadeefmwnsflleelin.

tntneinkkklyYNDQftwNHFLLECLVDQVKtwyWVLPIIHGYFVQDKIDIFGKGLDLILIARRSRYYAGARFLKRGINENGQVANDVETEQILQEPlt
            |...    . |  .| |.     .  ..|.|.. . .|.. .|   | ||.||| . ||.|||.||....|.||| ||||||..    
............yrsk...lsslekqlldnag...FlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvDddGnvanFVETEqIvyss..

gwsskAKFSSFVQIRGSIPLYWEQDNNIMTpKPPIKIQRMDP-FLGSTILHFQDLFQRFGSpIIILNLVKSNEkkpRESILRNEFTDCINcLNEMLPEqh
      .  ||.|.|||||..|||. | .. .|.|.| | .. .   .  ||. ||.. |  . |.||.|  .   .|  |. ..  ... |.| ..   
.....qycfsFtQvRGSiPiFWeqesnsli.gpkiqitrsseatqsafdkHFdklfekYGd.vhivNLlktKs...sEieLseryekhlk.lsekpki..

riHYQAWDFHQAAKSKDEDHMAWLDSFANQSiLKTGIFYS
  |.  .|||.... .  | .  |  .. |. |......|
..hlteFdfhketsqdgfddvkkLlplieqd.llefgyfs
subfamily_SAC1_pd Subfamily SAC1 142-504 5.6e-64 207.4 In-house 4-324 (458) alignment 
Range on Protein: 142-504
Range on HMM: 4-324/458.0
VCSAYGILGFIRFLHGYYIILITKKRKVGMIGTHFIYGIDDITYVYIPPSFPKTNSPEFADETRYKGLFLSLDLTKDFYFSYTYDITRTLQYNmtryfhs
| . .||||.|. | | |.|.||||..|| | .. || . |.. . .     .  . .  .|..|. |  ..  ...||||||||.|..|| .       
vvkiagilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrl.......

pipknipqtnnnSNNnnnNNTNTNTNEINKKklyYNDQFTWNHFLLECLVDQVKTWYWVLPIIHGYFVQDKIDIFGKGLDLILIARRSRYYAGARFLKRG
            ...   .......... ..    .. | ||. ||| | .. .   ..||.|.|.. . .. . .| ...|||.||| . ||.|. .||
............ekv...tsaalkersller...adeRffwnkhlledlrkepelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRG

INENGQVANDVETEQILQEPltgwsskAKFSSFVQIRGSIPLYWEQDNNImTPKPPIKIQRMDPFLGSTILHFQDLFQRFGSPIiILNLVksnEKKPRES
....|.||| ||||||..          ...||||.||||||.|.| .|.   || .|... .  | ..  |.... ...|. . ..|||   ..| .| 
vdkeGnvanfvEtEqiveae.......kaltsFvqvRGsiPllWsqkpnL.kykPkvklsesedsldafkkhldeqielygenv.lvnLv...dqkGsEk

ILRNEFTDCINCLNemlpeQHRIHYQAWDFHQAAKSKDEDHMAWLDSFANQSILKTGIFYSSS
 |.... . .. ||     ...|.|.|.|||.  ..   |... |    ..   ..|.|. |.
klgeayesvvraln.....kkkikyvafDFHkeCrkmrwdrlklLidqlekelsqegyflkse
subfamily_INPP5F_pd Subfamily INPP5F 266-680 3.7e-62 201.6 In-house 151-507 (951) alignment 
Range on Protein: 266-680
Range on HMM: 151-507/951.0
TNEINKK-----KLYyNDQFTWNHFLLECLVDQVKTW--YWVLPIIHGYFVQDKIDIFGKGLDLILIARRSRYYAGARFLKRGINENGQVANDVETEQIL
 .. ...     . . ...|.||.|||. |..  ..    ...|.| |.   ..| |  . ..| || ||||  ||.|| .|||...|.||| ||||.||
qkrgleeksestddw.derFfWNkfllkdlinyrdkldkefltpviqGfvetkeisieklkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElil

QepltgwsSKAKFSSFVQIRGSIPLYWEQDNNIMTPKPPIKIQRMDPfLGSTILHFQDLFQRFGSpIIILNLVKSnekKPRESILRNEFTDCINCLNeml
.       .. .  ||.|||||.|..|||..... ||. |. . ..   .    ||. .....|  . | ||..    | .|..| . . . .. |.   
s.......vekyvlsftqirGSvPvfweqsgkkykpkikitrseeet.qpaFdehfkeqlkkygk.vvivnllsq...kssekklskaykeqllkle...

peQHRIHYQAWDFHQAAKSKDEDHMAWLDSFANQSIlktgifysssklycnflrenynsssddnggsttttttttaattisglneKENELFSYLFNE-IG
  .... .   |||.  .... ...  | .  ...|                                                 ||   |||  .| . 
..skdvflikfdfheetsgekfenvsklieliknei.................................................kevgyfsydvkekvi

TEQIGVVRTNCIDSLDRTNAAQFCIGKCALGYQLYSMGLLDSPSLDFNTGIVQVLIDMYEACGNQIALQYGGSELANTikTYTK---HSLSSQSRDLVNA
 || ||.||||.|.||||| .|  |.| .|  ||  .||... |   .  ..| | ...   |..|  || |..      ..|.   ..|.    |... 
seqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessiddeellqklkklWadngdaisrqYagtnalkg..dltrkgerklaGvlkdgyks

IKRYISNSFIDADKQHSINLFLGYFV
..||  | | |. .|. |.| ||   
vsryylnnfkdkyrqkvidlllGklp
Sac_COG5329 556-710 6.5e-35 111.5 In-house 398-548 (1070) alignment 
Range on Protein: 556-710
Range on HMM: 398-548/1070.0
IGTEQIGVVRTNCIDSLDRTNAAQFCIGKCALGYQLYSMGLLDSPSLDfntGIVQVLIDMYEACGNQIALQYGGSELANTIKTYTK-HSLSSQSRDLVNA
.  || ||.||||.|.|||||..|..|.| .|. |..|..  .. . .    ..| |  ..   |..|. .|.|..  ..  |...  |......|... 
liseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde...dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkS

IKRYISNSFIDADKQHSINLFLGYFVPAKQIaiEKIPLWNLETDHYLHNITNRKQH
..|...|.| |. || .|.|.|| . .....  |...  |   ...|  . .. . 
vsRmyinnfvDkekQdaidllLgklpdqeav..elydpineyvnlrlrksesefta
subfamily_Synaptojanin_pd Subfamily Synaptojanin 141-505 1.3e-31 100.8 In-house 2-318 (754) alignment 
Range on Protein: 141-505
Range on HMM: 2-318/754.0
RVCSAYGILGFIRFLHG----YYIILITKKRKVGMIGTHFIYGIDDITYVYIppsfpKT----NspefadeTRYKGLFlSLDLTKDFYFSYTYDITRtlq
... |||.|| .|  .|     ...|.|   .|| |    |. | ....|..     ..    .        |.  |   |  .. |||| . | ..   
kivdaygllGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvsl.....rseasde.......driielk.kllasgtfyfsssadsas...

ynmtryfhspipknipqtnnnsnnnnNNNTNTNTNEINKKKLYyNDQFTWNHFLLECLV-DQVKTWYWVLPIIHGYFVQDKIDIFGKGLDLILIARRSRY
                          . . ...... ....   ...| ||. |   |   .|..  |.|... |      . .  |    .||.| |  
..........................rldlslsaqrrkqeese.dnrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsce

YAGARFLKRGINENGQVANDVETEQILQepltgwsSKAKFSSFVQIRGSIPLYWEQDnNIMTPKPPIKIQR-MDPFLGSTILHFQDLFQRFGSPIiILNL
 || ||  ||.|..|.||| |||||..           | .||||||||.||.|||   . . .  .|..| ..    .   |.. | .|.|. . |.||
raGtrfnvrGvndeGnvanfveteqvil.......lddkvtsfvqirGsvPlfWeqP.GlqvGshkvklsrgfeasaaafdrhleqlkeryGevv.ivnl

VksnEKKPRESILRNEFTDCINclneMLPEQHRIHYQAWDFHQAAKSKDEDHMA-WLDSFANQSILKTGIFYSSSK
.    .|  |..| ..| .  .    .   .. ...  .|.|| .|.. .....  |.  ... . ....|.|. |
l...Gskegeevlskafkkhlk....asehakdvpfvkfdyhqkvkggkkeklekllkkqlklflesasfflskgk
subfamily_SAC1_pd Subfamily SAC1 554-682 3.4e-25 79.6 In-house 326-456 (458) alignment 
Range on Protein: 554-682
Range on HMM: 326-456/458.0
NEIGTEQIGVVRTNCIDSLDRTNAAQFCIGKCALGYQLYSMGLLDSP-SLDFNTGIVQVLIDMYEACGNQIALQYGGSELANTIKTY-TKHSLSSQSRDL
..| .|| |||||||||.|||||  |  ... .|  || |.|.| .  .|. .. . ..  ...   ..... || |     |  |   |..|.   ||.
kkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskledsaeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDg

VNAIKRYISNSFIDADKQHSINLFLGYFVPA
||...||. | | |  .| ||.|||| ... 
vnsvsryyknnfldgerqdsidLflgkyrve
subfamily_Synaptojanin_pd Subfamily Synaptojanin 544-677 4.6e-20 62.6 In-house 308-434 (754) alignment 
Range on Protein: 544-677
Range on HMM: 308-434/754.0
KENELFSYLFNEIGTEQIGVVRTNCIDSLDRTNAAQFCIGKCALGYQLYSMGLLDSPslDFNTGIVQVLIDMYEACGNQIALQYGGSElanTIKTYTKhs
.....|.   .|.  || ||.|.||.| |||||| | ..|   |  ||  ..|   .  .  . . .|. ....  |..|.  | |.    .... .|  
esasfflskgkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlealklsske..svvsrfeevfkslWsknGdeiskiyaGtg...alegkak..

lSSQSRDLVNAIKRYISNSFIDADKQHSINLFL-G
 .|. .|   ...| | | |.|. || .|.|.| |
.vsklkdgarsvartiqnnfldsskqeaidllllg