Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_INPP5F_pd | Subfamily INPP5F | 196-686 | 2.3e-87 | 285.1 | In-house | 33-521 (951) | alignment | ||
Range on Protein: 196-686
Range on HMM: 33-521/951.0
NNNNNNNNNNSNNNNNNNSNNNNsnnSGNTNYDSLSSSSGGNSNNNNNYDSSYGNNNNNNNNNNNNSNNNNNNNNNNNNNNNNNSNNNNDPTVKQMLKDL
...... .... . .. .. . ...... .. . | . .. . . . ........ ||.. . . . ... ........|... . |..|..|
pvqkkeskkevvaiervakldls...ekdskelekeectgliglielegkiivatiegkskvnnkkwdlididssgylqlkeekeqneeeklekrlleel
QTFPLDgTHFYCEL-YDLTNYFPSNLNTPHQYC-----SEFTWNEWMRKPFENASLSH---LCVVLLQGYASVKSIS--NLNVSIAYLMKRSKLNPGTHF
.... | ..||..| .||||..... ....... ..|.||....|...|..... ......||....|.|| .|.||......||. ..||.|
kkllsd.gsFYysldfDltntlqkrgleeksestddwderFfWNkfllkdlinyrdkldkefltpviqGfvetkeisieklkvsltlisrrSrkragtrf
YSPGINENASPANEYESELIMwKVQDKqSILINNIASSSNSNLSDLDKKSNSNNNNNNNNNNNNNNNNNNSTSTASTTATaTAISSSLSIsSTTASLSLS
...||......||..|.|||. .|... .. ...|..| . .... .||............................... ..| ..|| ..... .
krrGidddgnvAnfvEtElil.sveky.vlsftqirGSvPvfweqsgkkykpkikitrseeetqpaFdehfkeqlkkygk.vvivnllsq.kssekklsk
SSSTAPNTITTTSTAIPKVDLNKNNDTDDSNNNNNSNGGLTNNTTNIIPNNNNINEKVIQWTSHVWRRGTVPLWWRA--FSKNQGSNEIELFLKDRGKEN
..... .......... |.|...........|..... ..|.............||||.....|.|........|. ........ .||.|...|. .
aykeqllkleskdvflikfdfheetsgekfenvsklielikneikevgyfsydvkekviseqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfe
PNPFEKSesyyQNLLNRYEKFYQENKDT---NLAGIPTIQLiNLLKQENDKQEVILSQLYQKSCENvttYLNVDLQMYTFDWINILKANNNSlsKTVQNL
|. .... ..||....|....|.|. ..||..... .| .....|....|...|...... ||| . ..|....|..|... .. . |..|
pessidd....eellqklkklWadngdaisrqYagtnalkg.dltrkgerklaGvlkdgyksvsry...ylnnfkdkyrqkvidlllGklpk..qevvel
WDSTKSS
| .|..
idpkkee
|
|||||||||
Syja_N | SacI homology domain | 271-666 | 1.1e-24 | 78.1 | Pfam-A | 57-313 (319) | alignment | ||
Range on Protein: 271-666
Range on HMM: 57-313/319.0
NnnnnnnnnSNNNNDPTVKQMLKDLQTFPLDGTHFYCELYDLTNYFPSNLNTP--------------HQYCSEFTWNEWMRKPFENAS--LSHLCVVLLQ
. ............|| |... .|..... ||||. . .. .. ... ..|.||... ||..... ||.....|.|
e........ekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliq
GYASVKSISNL---NVSIAYLMKRSKLNPGTHFYSPGINENASPANEYESELIMWKvqdkQSilinniasssnsnlsdldkksnsnnnnnnnnnnnnnnn
|... .||. .|... . .||. || . . ||.... ||. |.|.|... ..
GfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivse....kk......................................
nnnststasttatataissslsissttaslslsssstapntitttstaipkvdlnknndtddsnnnnnsnggltnnttniipnnnninEKVIQWTSHVWR
|. ...|.|.
........................................................................................eeskrvfSfvqi
RGTVPLWWRAFSKNQGSNEIELflkdrGKENPNPFEKSESYYQNLLNRYekfyqenkdtnlagiPTIQLINLLkqENDKQEVILSQLYQKSCENV--TTY
||.|||.| |. . ...|.. ... . . ......|..|| |...||| |. ..| ||. |.. .... ..
RGSvPlfWeqasnlslkpkiki.....trsseasqkafkkHfkklikrY...............gkivvvnLl..ekkgrEkkLseayeelinklnkklk
LNVDLQMYTFDWINILK
. .|.. .||. . |
ekkklkyiefDfhkeck
|
|||||||||
Syja_N | SacI homology domain | 271-666 | 1.1e-24 | 78.1 | In-house | 57-313 (319) | alignment | ||
Range on Protein: 271-666
Range on HMM: 57-313/319.0
NnnnnnnnnSNNNNDPTVKQMLKDLQTFPLDGTHFYCELYDLTNYFPSNLNTP--------------HQYCSEFTWNEWMRKPFENAS--LSHLCVVLLQ
. ............|| |... .|..... ||||. . .. .. ... ..|.||... ||..... ||.....|.|
e........ekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliq
GYASVKSISNL---NVSIAYLMKRSKLNPGTHFYSPGINENASPANEYESELIMWKvqdkQSilinniasssnsnlsdldkksnsnnnnnnnnnnnnnnn
|... .||. .|... . .||. || . . ||.... ||. |.|.|... ..
GfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEqivse....kk......................................
nnnststasttatataissslsissttaslslsssstapntitttstaipkvdlnknndtddsnnnnnsnggltnnttniipnnnninEKVIQWTSHVWR
|. ...|.|.
........................................................................................eeskrvfSfvqi
RGTVPLWWRAFSKNQGSNEIELflkdrGKENPNPFEKSESYYQNLLNRYekfyqenkdtnlagiPTIQLINLLkqENDKQEVILSQLYQKSCENV--TTY
||.|||.| |. . ...|.. ... . . ......|..|| |...||| |. ..| ||. |.. .... ..
RGSvPlfWeqasnlslkpkiki.....trsseasqkafkkHfkklikrY...............gkivvvnLl..ekkgrEkkLseayeelinklnkklk
LNVDLQMYTFDWINILK
. .|.. .||. . |
ekkklkyiefDfhkeck
|