Gene DDB_G0274537 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily INPP5F
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP052_AA protein Get Run
DdisP052_AA_736-1054 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_SAC1_pd Subfamily SAC1 688-1061 2.3e-151 495.5 In-house 90-457 (458) alignment 
Range on Protein: 688-1061
Range on HMM: 90-457/458.0
TTTTTTTTTLTESQETIYHLFEVFNSRFYWNKHLQTNL-IQGGFYNWVLPLIRGYVEIINFFIERNDIEFLLISRRSKFRAGTRYNTRGSDHNGNVANYV
|..   ..  |... .  .|.|....||.|||||...|  . .. ...||.|.|...| .. .....|.| |||||| |||||||..||.|..|||||.|
tnslqrlekvtsaalkerslleradeRffwnkhlledlrkepelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfv

ETEQIISHQdptsgkKTTFSFVQTRGSIPLIWEQTGR-KIKPEIKITqDNQLNSNSFRAHFDEQIKLYgpGPQVLVTLLDQKGSEAELGEAYRMMAVTSG
|||||....      |...||||.||||||.|.|... |.||..|.. ... ....|..|.||||.||  |..|||.|.||||||..|||||.... ...
EtEqiveae......kaltsFvqvRGsiPllWsqkpnLkykPkvkls.esedsldafkkhldeqiely..genvlvnLvdqkGsEkklgeayesvvraln

YREIDFVPFDFHHFCQGNRFDRVDILIDQLEEnIHQHIGYTERNSEQGYTQHQHGLTRTNCLDCLDRTNLVQSMIGVSVLERQLKRLGF---EWRIKDQs
...|..| ||||. |. .|.||...||||||.  ....||.....|. ....|.|..||||.|||||||.|||... .||..||..||.   |....|. 
kkkikyvafDFHkeCrkmrwdrlklLidqlek.elsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskleds.

LPGTRSIKLAWANNGDAISFQYAGTQALKGDYTRTGKRNTKGVFRDGVNSLTRYYINNFLDKIRQVSIDLFLGLTTVDT
 . ..|.| .||.|.||.|.|||||.||| |.||||||...|..||||||..|||.|||||..|| ||||||| ..|.|
aeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrvet
subfamily_INPP5F_pd Subfamily INPP5F 698-1068 1.9e-115 378.0 In-house 152-517 (951) alignment 
Range on Protein: 698-1068
Range on HMM: 152-517/951.0
TESQETIYHLFEVFNSRFYWNKHLQTNLIQGGFYN---WVLPLIRGYVEIINFFIERNDIEFLLISRRSKFRAGTRYNTRGSDHNGNVANYVETEQIISH
 ...|   . ......||.|||.|. .||.   ..   ...|.|.|.||. .  ||.. ..  ||||||..|||||...|| | .|||||.||||.|.| 
krgleeksestddwderFfWNkfllkdlinyrdkldkefltpviqGfvetkeisieklkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsv

QdptsgKKtTFSFVQTRGSIPLIWEQTGRKIKPEIKITQDNQLNSNSFRAHFDEQIKLYGPgpQVLVTLLDQKGSEAELGEAYRMMAVTSGYREIDFVPF
.     |. ..||.| |||.|. ||| | |.||.||||.... . . |. ||.||.| ||.  .| | ||.||.|| .|..||     ..  ... .. |
e.....ky.vlsftqirGSvPvfweqsgkkykpkikitrseeetqpaFdehfkeqlkkygk..vvivnllsqkssekklskaykeqllkleskdvflikf

DFHHFCQGNRFDRVDILIDQLEENIhQHIGYTERNSEQGYTQHQHGLTRTNCLDCLDRTNLVQSMIGVSVLERQLKRLGFEWRIKD-QSLPGTRSIKLAW
|||. ..|..|. |. ||......| ...||  ..... . ..|.|  ||||||||||||.||..|.  ||| ||..||     .  ..    . .|  |
dfheetsgekfenvsklieliknei.kevgyfsydvkekviseqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessiddeellqklkklW

ANNGDAISFQYAGTQALKGDYTRTGKRNTKGVFRDGVNSLTRYYINNFLDKIRQVSIDLFLGLTTVDTYKSAQNF
|.|||||| |||||.|||||.||.|.|.  ||  ||..|..|||.||| || ||  ||| || .  .  .  .. 
adngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkvidlllGklpkqevvelidp
Sac_COG5329 690-1057 2.3e-110 361.4 In-house 159-519 (1070) alignment 
Range on Protein: 690-1057
Range on HMM: 159-519/1070.0
TTTTTTTLTESQETIYHLFEVFNSRFYWNKHLQTNLIQGGFYN--WVLPLIRGYVEIINFFIERNDIEFLLISRRSKFRAGTRYNTRGSDHNGNVANYVE
. . .   ........   .  .. . .. .   .| .  . |  .  ..|||..| ... .... |   ||||||. |||||...|| | .|||||.||
lkeelelsvdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvDddGnvanFVE

TEQIISHQdptsgkKTTFSFVQTRGSIPLIWEQ-TGRKIKPEIKITQDNQLNSNSFRAHFDEQIKLYGPgpQVLVTLLDQKGSEAELGEAYRMMAVTSGY
||||.  .      ...|||.|.|||||..|||  .. |.| |.||.. .   . |  |||.... ||.  ...| ||..|.||.|| |.|.     |  
TEqIvyss......qycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGd..vhivNLlktKssEieLseryekhlklsek

REIDFVPFDFHHFCQGNRFDRVDILIDQLEENIHQHiGYTE-RNSEQGYTQHQHGLTRTNCLDCLDRTNLVQSMIGVSVLERQLKRLGFEWRIKDQslPG
 .|... ||||. .. ..||.|  |....|. . .  ||..  ..|. ... |.|  ||||||||||||..|..|.  ||  |.. ..    |.|.  . 
pkihlteFdfhketsqdgfddvkkLlplieqdllef.gyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde..df

TRSIKLAWANNGDAISFQYAGTQALKGDYTRTGKRNTKGVFRDGVNSLTRYYINNFLDKIRQVSIDLFLGLT
  ...  ||.|||||| .| ||.|||...||.|||  .| ..| ..| .|.||||| || .| .|||.||  
lqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgkl
Syja_N SacI homology domain 574-906 4.2e-94 306.2 Pfam-A 1-318 (319) alignment 
Range on Protein: 574-906
Range on HMM: 1-318/319.0
AYGIVGIINLLSGPYLIVITGKQLIGSFGG-KYIYRIENCNLILISNNPTDLS------EHDRKMESTYKKSLKNLLK-SNFYYCFDYNISDNIENHFKN
||||.|.|.|||. ||.|||... .....| . ||.|.....| ....... |      |...|.|. . | ||.||. ..||...||... ........
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

HHNKQTNNNTNVneentttttttttttttttltesqetiyHLFEVFNSRFYWNKHLQTNLIQGG--FYNWVLPLIRGYVEIINFFIE-RNDIEFLLISRR
............                            .|.. ...||.||..|...||. .    .|.||||.|.||. .. ..  ...|..|||||
eeeekeeesksl............................pllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRr

SKFRAGTRYNTRGSDHNGNVANYVETEQIISHqdPTSGKKTTFSFVQTRGSIPLIWEQ-TGRKIKPEIKITQDNQLNSNSFRAHFDEQIKLYgpGPQVLV
|. ||||||..|| |..|||||.||||||.|    .. .|..|||||.|||.||.||| .. ..||.||||.... ... |. ||...|| |  |..|.|
svkraGtRylrRGidddGnvANfvEtEqivse..kkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrY..gkivvv

TLLDQKGSEAELGEAYRMMAVTS-----GYREIDFVPFDFHHFCQGNRFD
 ||..||.|..|.|||. .. .        ...... ||||. |.|..|.
nLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfe
Syja_N SacI homology domain 574-906 4.2e-94 306.2 In-house 1-318 (319) alignment 
Range on Protein: 574-906
Range on HMM: 1-318/319.0
AYGIVGIINLLSGPYLIVITGKQLIGSFGG-KYIYRIENCNLILISNNPTDLS------EHDRKMESTYKKSLKNLLK-SNFYYCFDYNISDNIENHFKN
||||.|.|.|||. ||.|||... .....| . ||.|.....| ....... |      |...|.|. . | ||.||. ..||...||... ........
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

HHNKQTNNNTNVneentttttttttttttttltesqetiyHLFEVFNSRFYWNKHLQTNLIQGG--FYNWVLPLIRGYVEIINFFIE-RNDIEFLLISRR
............                            .|.. ...||.||..|...||. .    .|.||||.|.||. .. ..  ...|..|||||
eeeekeeesksl............................pllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRr

SKFRAGTRYNTRGSDHNGNVANYVETEQIISHqdPTSGKKTTFSFVQTRGSIPLIWEQ-TGRKIKPEIKITQDNQLNSNSFRAHFDEQIKLYgpGPQVLV
|. ||||||..|| |..|||||.||||||.|    .. .|..|||||.|||.||.||| .. ..||.||||.... ... |. ||...|| |  |..|.|
svkraGtRylrRGidddGnvANfvEtEqivse..kkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrY..gkivvv

TLLDQKGSEAELGEAYRMMAVTS-----GYREIDFVPFDFHHFCQGNRFD
 ||..||.|..|.|||. .. .        ...... ||||. |.|..|.
nLlekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfe
subfamily_Synaptojanin_pd Subfamily Synaptojanin 574-1060 4e-85 277.8 In-house 6-439 (754) alignment 
Range on Protein: 574-1060
Range on HMM: 6-439/754.0
AYGIVGIINLLS----GPYLIVITGKQLIGSFGGKYIYRIENCNLILISNNPTDLsehdrkmeSTYKKsLKNLLKSNFYYCFdynisD-----Nienhfk
|||..|...| .      .|...|| . .|   .  |..| . .|. . ....|         . . . ||.||.|. .|             .      
aygllGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvslrseasde........driie.lkkllasgtfyfs.....ssadsas......

nhhnkqtnnntnvneenttttttttttttTTTLTE-SQETIYHLFEvfNSRFYWNKHLQTNLIQGGF--YNWVLPLIRGYVEIINFFIERNDIEFLLISR
                             .  |.  .|.   .  |  ..||.||. | ..| . |    .|.|....| |||   ..  . .. .||||
.............................rldlslsaqrrkqeese..dnrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisr

RSKFRAGTRYNTRGSDHNGNVANYVETEQIISHQDptsgkkTTFSFVQTRGSIPLIWEQTGRKI-KPEIKITQDNQLNSNSFRAHFDEQIKLYGpgPQVL
 |  |||||.|.|| ...|||||.|||||.|. .|      .  ||||.|||.|| ||| | .. .  .|.... . .. .|  |.... . ||   .|.
lsceraGtrfnvrGvndeGnvanfveteqvilldd......kvtsfvqirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryG..evvi

VTLLDQKGSEAELGEAYRMMAVTSGY-REIDFVPFDFHHFCQGNRFDRVDILIDQLEEN-IHQHIGYTERNSEqgYTQHQHGLTRTNCLDCLDRTNLVQS
| || .|..|. | .|..    .| . ....|| ||.|. ..|.. . .. |...  .. ....  ......|   ...|.|. |.|||||||||| ||.
vnllGskegeevlskafkkhlkasehakdvpfvkfdyhqkvkggkkeklekllkkqlklflesasfflskgke..vekeqtGvlrvnClDCldrtnavqt

MIGVSVLERQLKRLGFEWRikDQSLP-GTRSIKLAWANNGDAISFQYAGTQALKGDyTRTGKrntkgvFRDGVNSLTRYYINNFLDKIRQVSIDLFL-GL
..|  |||.||. |. . .   . .   ... |  | .||| ||  ||||.||.|. ....|      ..||  |..|   |||||  .| .|||.| | 
vlglevlekqlealklssk..esvvsrfeevfkslWsknGdeiskiyaGtgalegk.akvsk......lkdgarsvartiqnnfldsskqeaidllllgn

TTVD
| |.
tyve
subfamily_FIG4_pd Subfamily FIG4 567-1075 1.9e-82 268.4 In-house 63-557 (569) alignment 
Range on Protein: 567-1075
Range on HMM: 63-557/569.0
LHQQSILAYGIVGIINLLSGPYLIVITGKQLIGSFGGKYIYRIENCNLILISNNPTDlsEHDRKMESTYKKSLKNL-LKSNFYYCFDYNISDNIENHFKn
  .... ||||.|.. .|.| |||..| .. ... ||  ||.||. .|| |... .   ...   |. |.| .|.. |..|||. . |...  . .    
glekkvsayGilGfvrflegyylilvtkrkkvaviGghaiykiedialikitedskk..sekssdearylklfkdvdltknfyfsysydltrtlqtnll.

hhnkqtnnntnvneenttttTTTTTTTTTTTLTESQETIYHLFEVFNSRFYWNKHLQTNLIQGGF-YNWVLPLIRGYVEIINFFIERNDIEFLLISRRSK
                    .. ........  ... ||.      | .| ||..|   | .    ..|.| .| |.|.  . ..  ..|.  ||.|||.
....................lsdsnrekekaedrvditieakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgksiyvtliarrss

FRAGTRYNTRGSDHNGNVANYVETEQIISHQDPTSGKK-TTFSFVQTRGSIPLIWEQTGRKI--KPEIKITQDNQLNSNSfRAHFDEQIKLYGpGPQVLV
  ||.|.  || ...|.|||.||||||...   .| ..    ||||.|||.|| |.|   |.  ||.||| . .   | .   |||. .. || .| ...
kfaGarflkrGvnnkGdvaneveteqivheasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaa.alhfddlfqryG.spiiil

TLLDQ---KGSEAELGEAYRMM-----AVTSGYREIDFVPFDFHHFCQGNRFDRVDILiDQLEENIHQHIGYTERNSEQGYTQHQHGLTRTNCLDCLDRT
 |. .   .  |. | |..         .    ...... .|...  . .  . ...| ... |.. .. |.  ....   |. |.|. ||||.||||||
nlvkkkekrkresilleefeaaieylneflPeekklkyiswdmaraskskeenvlevl.ekyaeksvkktGiflsapdlestkiqeGivrtnCvdcldrt

NLVQSMIGVSVLERQLKRLGFewrIKDQSLP----GTRSIKLAWANNGDAISFQYAGTQALKGDYTRTGKRNTKGVFRDGVNSLTRYYINNFLDKIRQVS
|  | .||   |  |||.||.   |.. .|      .| ..  . . || ...||.|.|  .   | .  .. .   || ...|.||| | | |. .| .
naaqfvigkvalgyqlkslGi...idesklefdsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqda

IDLFLGLTTVdtYKSAQNFRSIQNEY
|.||||  .    .. ...  .. ..
inlflGvysp..reglpslWeletdf
hSac2 Inositol phosphatase 1070-1182 1.6e-33 103.7 Pfam-A 2-114 (115) alignment 
Range on Protein: 1070-1182
Range on HMM: 2-114/115.0
SIQNEYDWGESRMDAINNCvDHFLRSKeSstlgEGFINAWIVISINKRN---QEQERILLLTPSHLVRCKYNFNENKIVHFKQFNLTSIKRIQMGVIDNN
| ..|....|.|..||..| ....... .    |..|..|...||...|   .|.||.|||| ..|. |||.|...|...|....|.|||.|..| ....
skdpeiereelreqaiekc.kklvlpd.d....eeliggWlLvsidhsnktlteeervLLLTdkalyvckYDfetekvtqferidLesikkieiGtyses

G---KKMNSYAIKIFHKSS
    .|.......| ...|
tlsedksenlglrinyrks
subfamily_SAC1_pd Subfamily SAC1 575-670 4.5e-27 85.8 In-house 8-104 (458) alignment 
Range on Protein: 575-670
Range on HMM: 8-104/458.0
YGIVGIINLLSGPYLIVITGKQLIGSFGGKYIYRIENCNLILISNNPTDLSEHDRKMESTYKKSLKNLLKSN-FYYCFDYNISDNIENHFKNHHNKQ
.||.|||.||||.|||||| |. .|.. ||.|||......| ...|...|.|...|.|..|.| |...|||. ||....|...  .. . |. ... 
agilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekvtsaal
Sac_COG5329 574-672 3.6e-13 39.6 In-house 61-168 (1070) alignment 
Range on Protein: 574-672
Range on HMM: 61-168/1070.0
AYGIVGIINLLSGPYLIVITGKQLI-GSFGGKYIYRIENCNLILISNNPTDLSEHDRKMESTYK-------KSLKNLLK-SNFYYCFDYNISDNIENHFK
 ||. |.|.|    .|||||||.   . ..|. ||.|..   | . ||  | .| ..   ||.|        .|| ||. . ||.  |. |.. . .. |
iygvlGlielegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsngsFYfStdfditntLqkrlk

NHHNKQTN
. .. ...
eelelsvd