Gene DDB_G0284737 in Dictyostelium discoideum

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily PGP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DdisP067_AA protein Get Run
DdisP067_AA_23-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PGP_pd Subfamily PGP 24-299 3.1e-103 335.9 In-house 1-277 (279) alignment 
Range on Protein: 24-299
Range on HMM: 1-277/279.0
TFIFDCDGVLWIADTIVPGAIETLNYLRqTLGKKILFVTNNSTKTRQQFLEKIKSFNIE-AFIDEVYGSSYGAAIYLNQinfPKETKKVFIIGEHGLEKE
|..||||||||. .|..|||.|.||.|. .||||.|||||||||.|...|.|.|....|    .|.. |.. .| ||.|    |..|||...||.||..|
tvlfDcDGVlWlgetaipgaaealnaLk.klgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkq...kkfekkvyvlgeeglkee

LNDQNFKTIK-EINKLKDGLD--SVQNTAIDKDVGAVIVGMDTQLTFQKATYAHMCIKEIEgCLFIATNPDTSYPVKNEKTLPGAGSIVAMIQTSTGVKP
|......... . .|||| ||   |.....|||||||.||.|..|...| ..|.....| | .||.||| |. .|.|.|...|||||.||.|....| ||
LkeagiellgtgpeklkdeldedfveelkldkdvgAVvvgvdeklsyakllkAanyLrepe.vlflatneDallplkkevvipgaGslvaaieaasgrkp

ITIGKPETLLLDVILKKDNLNPERTLFVGDRLDTDIAFAVNGGIRSLLVLTGISKLNEINNIDS--KINPNYYTNTIADLLP
...|||..|||...|.| ...|||||..||||.|||.|. | |...||||.|..||.....|..  | .|.||....||||.
lvlGKPnelllelllekeeidpertlmiGDrlktDilfgkncGlqtLlvlsGvtkledveeikkeeklvPdyyldsladlle
Chronophin_1 24-298 1.7e-72 235.0 In-house 3-256 (261) alignment 
Range on Protein: 24-298
Range on HMM: 3-256/261.0
TFIFDCDGVLWIADTIVPGAIETLNYLRQTlGKKILFVTNNSTKTRQQFLEKIKSFNIE-AFIDEVYGSSYGAAIYLNQinfPKETKKVFIIGEHGLEKE
....|.||||.  ...|||| |... |.|  ||..|||||||..||... ...| . .. .  .|.. | . || .|.|   .. . ||...||.|| ||
lvLlDldGVlikgeeavpgAaeliealkqa.gkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrq...qaakakvyvlGeeglrke

LNDQNFKTIKEINKlkdgldsvqntaidkDVGAVIVGMDTQLTFQKATYAHMCIKEieGCLFIATNPDTSYPVKNEkTLPGAGSIVAMIQTSTGVKPITI
|... .....| ..               .| ||.||.| .|.|.| . | . |..  |.||.|||.|.  | ..   .||.||..|.... .| .|. .
lreaGlrlvdeped...............rveaVvvGydeelsfeklaeaialird..galfvatnrDptvPleeG.iaPgtGslaaaveaAsgreplvv

GKPETLLLDVILKKDNLNPERTLFVGDRLDTDIAFAVNGGIRSLLVLTGISKLNEINNIDSKINPNYYTNTIADLL
||||... . .|.| ...||.|. ||||||||| .. . |...||||||.|.|.|.... ... |... ..|||||
GKPepvmfeealekigadpeetvmvGDRldTDilagaraglstllvltGvseleeaqaykkdlrPdavvesiadll
Chronophin_2 24-300 6e-67 216.8 In-house 2-279 (282) alignment 
Range on Protein: 24-300
Range on HMM: 2-279/282.0
TFIFDCDGVLWIADTIVPGAIETLNYLRQtLGKKILFVTNNSTKTRQQFLEKIKSFNIEA-FIDEVYGSSYGAAIYLNQinFPKETKKVFIIGEHGLEKE
. .||||||.|  ...|.|| | .. | . .||..||||||||..|... .|.  . .     .... |.| .| || .   ..   |||.|| .|| ||
nvlfdcdgviwngekavagapevvsrlar.agknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrd..vadvrgkvfviggeglrke

LNDQNFKTIKEINKLKdglDSVQNTAIDKDVGAVIVGMDTQLTFQKATYAHMCIKEIEgCLFIATNPDTSYPVKNEKTLPGAGSIVAMIQTSTGVKPITI
|..   . ... .. .    |. ..| | || ||.|| | .||| | . |   ... . ||..||..|  .|... . .||.||. | ..|..| | . |
lreagvpvvedadeqe...asiydcaldpdvravlvgydekltflklakacaylrdad.clllatdrdpwhplsdgritpgsgsltaaletasgrkatvi

GKPETLLLDVILKKDNLNPERTLFVGDRLDTDIAFAVNGGIRSLLVLTGISKLNEINNIDS-------KINPNYYTNTIADLLPS
|||   ... | .. ...| |.|..||||.||| |  | |. ..| |||.|.|.| ..  .       .. |.|. ..|||||..
gkpsrfmfecissqfsvdparslmigdrletdilfgsncglstvltltgvssleeaqeysdsqlaeqrdlvpdyvvesiadllea
Hydrolase_6 Haloacid dehalogenase-like hydrolase 25-129 1.3e-29 93.6 Pfam-A 1-101 (101) alignment 
Range on Protein: 25-129
Range on HMM: 1-101/101.0
FIFDCDGVLWIADTIVPGAIETLNYLRQTlGKKILFVTNNSTKTRQQFLEKIKSFNIEAFIDEVYGSSYGAAIYLNQINFpkeTKKVFIIGEHGLEKELN
|.||.|||||  |...||| |.|. ||.. ||.....||||.|.......|........  ..|. |.. || ||.....    |||..||| ||..||.
flfDvdGvLwrgdkaipgaaealkalraa.gkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkrka...dkkvlvigeeglreelk

DQNFK
. .||
eaGfk
subfamily_LHPP_pd Subfamily LHPP 25-271 1.5e-28 91.2 In-house 1-219 (227) alignment 
Range on Protein: 25-271
Range on HMM: 1-219/227.0
FIFDCDGVLWIADTIVPGAIETLNYLRQTlGKKILFVTNNSTKTRQQFLEKIKSFNIEAFIDEVYGSSYGAAIYLNQINFpketKKVFIIGEHGLEKeLN
.. |  |||.. |. .|||.| |. |||. |.|. ||||.. ..... .|... . ..   .|.. |   |. .|.. .     ...... ..  |. ..
vllDlsGvlhnedaaipgavealkrLrqa.gvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerkl....rpyllveddveed.fe

DQNFKTiKeinklkdgldsvqntaidkdvGAVIVGMD-TQLTFQKATYAHMCIKEIEGCLFIATNPDTSYPVKNEkTLPGAGSIVAMIQTSTGVKPITIG
| . .  .                      ||..|    ...... . |.  ..|...   || |..  |  |.     |.|. |. .. .||||   .|
didtdk.p.....................navviglapesfeyetlnqafrllleakkakliainkgkyykrkdG.lalgpGafvkaleyatgvkaevvG

KPETLLLDVILKKDNLNPERTLFVGDRLDTDIAFAVNGGIRSLLVLTG
||. |. .  |.. ...||. . .|| .  |.  |.. |.|..|| ||
KPsalffekaleelgvdpeeavmiGDdvedDveGAlkaGlrgvlVktG
Hydrolase_like HAD-hyrolase-like 222-297 1.6e-16 51.4 Pfam-A 2-75 (75) alignment 
Range on Protein: 222-297
Range on HMM: 2-75/75.0
IGKPETLLLDVILKKDNLNPERTLFVGDRLDTDIAFAVNGGIRSLLVLTGISKLNEINNidSKINPNYYTNTIADL
.|||.  ..| .|.. ...|.... .||.|.|||..| | ||||.|||||.|.  . .   .|..|.|. ......
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlkl..akakpdyvvddleea
Hydrolase haloacid dehalogenase-like hydrolase 22-260 4.5e-13 41.4 Pfam-A 1-213 (215) alignment 
Range on Protein: 22-260
Range on HMM: 1-213/215.0
IDTFIFDCDGVLWIADTIV--PGAIETLNYLRQT-------LGKKILFVTNNSTKT--RQQFLEKIkSFNIEAFIDEVygssY-GAAIYLNQINFP-KET
|.|..||..|.|.     |  .|. . |......       .||.. ... ...     . |.. |    .....|..    . |   ......   .  
iktvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstrggltgfatfi.grgvsgkvdgi....vlgnpewmtalglrviap

KKVFIIGehglekelndqnfktikeinklK----------DgldsvqntaidkdvGAVIVGMDTQL--TFQKATYAHMCIKEIEGCLFIAT--NPDTSYP
..|  .|                                                 |...|. ..     ..|  |   .||    ....|  ||.|   
dlvaaeg......................qskgrtvvvvav..............qaralgviafadpvkpeaaeavasLkeaGievvlltgdnpetaea

VKNEKTLpgAGSIVAMIQTstgvkpitiGKPETLLLDVILKKDNLNPERTLFVGDRLdTDIAFAVN
. ..  .  ..|.|    .         ||||  |.  .... ...|.....|||.. .|.... .
iakqagi..edslvfaevv.........gkPepklfvaaieeLqidpgevamvGDgv.nDapalaa
subfamily_CUT_pd Subfamily CUT 20-83 1.5e-06 17.9 In-house 16-85 (391) alignment 
Range on Protein: 20-83
Range on HMM: 16-85/391.0
DSIDTFIFDCDGVLWIADTIVPGAIETLNYLRQTLGK---KILFVTNNSTKTRQQFLEKI---KSFNIEA
.|  ....| ||||     ..|.| | |. | .  |.    ..|.||..  | ..  ||.     ....|
assfgivlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevda
Subfamily.CECR5.protein 24-80 3e-06 16.9 In-house 22-84 (393) alignment 
Range on Protein: 24-80
Range on HMM: 22-84/393.0
TFIFDCDGVLWIADTIVPGAIETLNYLRQTLGK---KILFVTNNSTKTRQQFLEKI---KSFN
....| ||||     ..|.| | |. | .  |.    ..|.||..  | ..  ||.     ..
givlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdve