Gene CG7378 in Drosophila melanogaster

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP3
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP021_AA protein Get Run
DmelP021_AA_68-231 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP3_pd Subfamily DSP3 69-231 1.4e-72 236.7 In-house 9-161 (162) alignment 
Range on Protein: 69-231
Range on HMM: 9-161/162.0
VDCDEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEGcRYGQVDTGHSYYRDMPsirrshkdcvFRYMGFPMVDAPTTDISRYFYVASKFIDSAISS-G
 ..|||||..|.||.|.||.|..|. .||||||||||| |. .||||...|.|.           ..|.|... |.|..|.|.||. |.||||.|.|.  
kevdevypklyvgdeavakdkskLkklGithvlnaaeg.rfskvdtgaefykdle..........ikylGlevdDvpefdlskyFetaakfidealsqke

GKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRDIRPNDGFLQQLADLDMELKRKN
||.|||| ||.|||||.|||||||.|||..|.||||||..|.|.||.|||.|||.||.|||||.
gkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeldeelkrkk
0044763 (Phosphotyrosine protein) phosphatases II 61-230 2.1e-42 140.1 In-house 13-173 (178) alignment 
Range on Protein: 61-230
Range on HMM: 13-173/178.0
RAECAIHDVDCDEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEGCRYGQVDTGHSYYRDMPsirrshkdcvFRYMGFPMVDAPTTDISRYFYVASKFI
. ....   ...|..||.|.|.. .|... .|. .||||..| .| ...|.... . .....           ..|. .|..| ...|....|. . .||
eglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeag..........iqylhipipDhgvpdllehflefvefi

DSAI-SSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRDIRPNDGFLQQLADLDMELKRK
..|. ..||..||||  |..||.|.|.||||.....|. .||. ||.|| | ||.|.|.|| .....|. .
eealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllke
PTPc_motif_SM00404 72-223 2.3e-34 113.3 In-house 3-137 (140) alignment 
Range on Protein: 72-223
Range on HMM: 3-137/140.0
DEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEGCRYGqvdtghsyyrdmpsirrsHKDCVFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKIL
 .. |..|.| . .|.|.  |  .|||||.|..| ..                     ..  |...  |. |  ....|.|.  . .||..|...|||.|
srilphlylgskskaqnpallkklgithvinvteevslt..................kensgfqilqiplddnekdklskyldkvldfienaekkggkvl

VHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRD-IRPNDGFLQQLADL
||| .|.||||| ..||||  |..|. .|.. |. ||. |.|| .|..|| ..
VHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLiey
0041856 (Phosphotyrosine protein) phosphatases II 63-230 5.2e-34 112.8 In-house 11-175 (182) alignment 
Range on Protein: 63-230
Range on HMM: 11-175/182.0
ECAIHDVDCDEVYPGIYIGDAAA--------------AKNKTYLRLMGITHVLNAAegcrygqvdtGHSYYRDMPsirrshKDCVFRYMGFPMVDAPTTD
 .  |. |.|.. ...|.|.  |              |.. ..|. .|||...|..          .. |. .        .. ...|. .|. | ...|
lpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..........eelywpell......erlgiqylylpwpDhgvpd

isryFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRD---IRPNDGFLQQLADLDMELKRK
    .. . .||. ....||..||||  |..|..| |.||||.....|. .|...||.||    |.|| .|. ||| |.. | .|
....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
0048076 (Phosphotyrosine protein) phosphatases II 72-227 2.9e-33 109.9 In-house 5-142 (145) alignment 
Range on Protein: 72-227
Range on HMM: 5-142/145.0
DEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAaegcrygqvdtghsyyrdmPSIRRSHKDCVFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKIL
.|..||.|.|.  .|..  .|. .|||.|||                     | .. ... ...|. .|. | .. |...... . .||..|...||..|
seilpglylgslptaldlellkdlgittvlnl...................tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvl

VHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRR-DIRPNDGFLQQLADLDMEL
|||  |..|..| |.||||.....|. .|.. ||..|  . ||.|.|..| ....||
VHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0045098 (Phosphotyrosine protein) phosphatases II 56-230 1.1e-32 109.0 In-house 7-274 (278) alignment 
Range on Protein: 56-230
Range on HMM: 7-274/278.0
LPGLRRAECAIHDVDCDEVYPGIYIGDAA-----------------------------------------AAKNKTYLRLMGITHVLNAAEGCRYGQVDT
|. |   |  ..  . .|..|..|.|...                                         .|..  .|. .|||......|   .|..  
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

GHSYYRdMP----------------------------------SIRRSHKDCVFRYMGFPMVDAPTTDISRYFYVASKFIDSAIS--------------S
 . ..  .                                   .   |.. ... |...|  ..|...|...|  . .||..|..              |
aqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

GGKILVHCLVGMSRSATCVLAYLMICR---KMSAVDAIRTVRMRRD--IRPNDGFLQQLADLDMELKRK
||..||||  | .|..| |.||||...   .... .|....|..|   . .| .....| .. .|| ..
ggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0048179 (Phosphotyrosine protein) phosphatases II 72-224 2.8e-32 106.8 In-house 5-141 (144) alignment 
Range on Protein: 72-224
Range on HMM: 5-141/144.0
DEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEGCrygqvdtG------HsyyrdmpsirrshkdcVFRYMGFPMVDAPTTDISRYFYVASKFIDSAIS
.|..||.|.|.  .|..  .|. .|||.|.| .|..              .                ...|. .|. | .. |.. ... . .||..|..
seilpglylgslptaldlellkklgittvinlteey.......epeflere................giqylhlpwpDhgvpdllellleflefieeale

SGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRR-DIRPNDGFLQQLADLD
.||..||||  |..|..| |.||||.....|. .|.. ||.||  . ||.|.|..| ...
eggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleye
subfamily_DSP1_pd Subfamily DSP1 65-228 3e-32 106.0 In-house 13-157 (163) alignment 
Range on Protein: 65-228
Range on HMM: 13-157/163.0
AIHDVDCdEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEGCrygqvDtghSYYRDmpsirrshkdcVFRYMGFPMVDAPTTDISRYFYVASKFIDSAI
 ..|  . .. . .|.| .  | |.  |. .|||..||... .     |    ...|           .|.|.  .. | |. ||| .|. . .|||...
klydPve.kildfLylGsetvasnleiLkslgitailnvskel.....d...nvfed...........lfeYkklkleDspkadislvfeeviefidevk

SSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRDI-RPNDGFLQQLADLDMELK
...||.|.|| .|.|||.| .|||||  ...|  .|   |. || | .|| || .|| . . .|.
kknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
DSPc Dual specificity phosphatase, catalytic domain 78-223 3.3e-31 102.9 Pfam-A 1-130 (133) alignment 
Range on Protein: 78-223
Range on HMM: 1-130/133.0
IYIGDAAAAKnKTYLRLMGITHVLNAAEGCRYGqvdtghsyyrdmpsirRSHKDCVFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKILVHCLVG
.|.| . .|. .. |  .|||.|.|... ..                  .. |.  ..|.. |. |  .|.||...  |..||..|...|.|.||||  |
lylgskstas.lalleklgitlvinvtkevpnn................naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaG

MSRSATCVLAYLMICRKMSAVDAIRTVRMRRD-IRPNDGFLQQLADL
.||||| ..||||  ...|. .|.. |. ||. |.||.|||.|| ..
isRSatliiaYlmktknlslneAyefvkerrskispnagflrqLley
DSPc Dual specificity phosphatase, catalytic domain 78-223 3.3e-31 102.9 In-house 1-130 (133) alignment 
Range on Protein: 78-223
Range on HMM: 1-130/133.0
IYIGDAAAAKnKTYLRLMGITHVLNAAEGCRYGqvdtghsyyrdmpsirRSHKDCVFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKILVHCLVG
.|.| . .|. .. |  .|||.|.|... ..                  .. |.  ..|.. |. |  .|.||...  |..||..|...|.|.||||  |
lylgskstas.lalleklgitlvinvtkevpnn................naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaG

MSRSATCVLAYLMICRKMSAVDAIRTVRMRRD-IRPNDGFLQQLADL
.||||| ..||||  ...|. .|.. |. ||. |.||.|||.|| ..
isRSatliiaYlmktknlslneAyefvkerrskispnagflrqLley
0046846 (Phosphotyrosine protein) phosphatases II 63-228 8e-31 102.5 In-house 4-173 (176) alignment 
Range on Protein: 63-228
Range on HMM: 4-173/176.0
ECAIHDVDCDEVYPGIYIGDAA----------AAKNKTYLRLMGITHVLNAAEG--------CRYGQVDTGHSYyrdmpsirrshkdcvfRYMGFPMVDA
   ..| |.|........|..            |..  .|. .|||.|.|  |         ..| .. .....                .|. .|..| 
rllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi................qylhlpwpDh

PTTDIsRYFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMIC-RKMSAVDAIRTVRMRR--DIRPNDGFLQQLADLDMELK
 . |. .... . .||..|...||..||||  |..|..| |.|||... . .|. .|...||..|   . ........| .  ..|.
gvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll
subfamily_DSP15_pd Subfamily DSP15 72-225 1.2e-30 100.7 In-house 3-137 (151) alignment 
Range on Protein: 72-225
Range on HMM: 3-137/151.0
DEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEgcrygqvdtghsyyrdmpSIRRSHKDcvFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKIL
..| ||.|.|.   .|... |.   |||.|.  .                  . ..  ||  ..|  ... |.| ...|..|  . .|| .. . ....|
skvlpglylgnfrdskdeelLkeknithilsvhd..................nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvl

VHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRDI-RPNDGFLQQLADLDM
||||.|.|||.| | ||||   ...  ||.......| .  || || .|| . ..
vhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek
0049772 (Phosphotyrosine protein) phosphatases II 86-232 1.4e-30 102.5 In-house 160-278 (314) alignment 
Range on Protein: 86-232
Range on HMM: 160-278/314.0
AKNKTYLRlmgithvlnaaegcrygQVDTGHSYYrdmpsirrshKDCVFRYMGFPMVDaPTTDISRYFYVASKFIDSAiSSGGKILVHCLVGMSRSAT-C
|..  .|.                 .. . ....          .. ...|. .|. | ........|. . .||..| . ||..||||  |..|..| .
aadlellk.................eelydpelf..........erlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfv

VLAYLMICRKMSAVDAIRTVRMRRDIRPNDGFLQQLADLDMELKRKNL
|.||||.....|. .|.. ||..| |.||.||..|| .. ..|.... 
vaaylmkllgvsleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_DSP14_pd Subfamily DSP14 71-231 3.5e-30 99.0 In-house 7-148 (157) alignment 
Range on Protein: 71-231
Range on HMM: 7-148/157.0
CDEVYPGIYIGdAAAAKNKTYLRLMGITHVLNAAEgcrygQVDTghsyyRDMPSIRrshkdcvfrYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKI
. .. | .... ..||..|..|.  .||...|..      .. .     .....|.         ..  |. |.|.......|  ... |...  .|||.
lsqitpsLfls.gvaalskellkkkkitliinvtv.....elpn.....tklkdie.........rvkvpveDnpeaklakhfdevadkieevkkkggkt

LVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRD-IRPNDGFLQQLADLDMELKRKN
||||  |.||||. .|||||  .|.|  .| ..|. .|  |||| || .|| |.. .|| |.
lvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgks
subfamily_DSP12_pd Subfamily DSP12 72-220 1.1e-29 97.9 In-house 3-136 (155) alignment 
Range on Protein: 72-220
Range on HMM: 3-136/155.0
DEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEGCRygqvdtghsyyrdmPSI--RRSHKDcvfrYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGK
... ||.|.|...|..... |. ..|||||  ..                 |.   ......    .   ...| |..|| ...  | .||..|.. .|.
srilpglylggleavqeeellkelkithvlsvikeel..............pehklkkgkvs....tkfiqilDepeediLshldeavdFieealeeega

ILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVR-MRRDIRPNDGFLQQL
.|||| .|.|||.| |.||||   |.|  .|...|. ....|.||.|||.||
vlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQL
0043147 (Phosphotyrosine protein) phosphatases II 72-223 5.5e-29 96.5 In-house 20-156 (172) alignment 
Range on Protein: 72-223
Range on HMM: 20-156/172.0
DEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEGcrygqvdtghsyyrdmPSIRRSHKDCVFRYMGFPMVDAPTTdISRYFYVASKFIDS--AISSGGK
|.. .. . ..   |..  .|. .||||..|. |                   ..   .. ...|. .|. | ... ...... . .|||.  |.|.||.
drfiatqgplrntladfwrmlkelgithivnltel................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggp

ILVHCLVGMSRSATCVLAYLMIcRKMSAVDAIRTVRMRRD-IRPNDGFLQQLADL
.||||  |..|..| |.||||. ...|. .|...||..|  . .|......| ..
vlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyf
subfamily_DSP10_pd Subfamily DSP10 62-231 8.6e-29 94.4 In-house 5-157 (159) alignment 
Range on Protein: 62-231
Range on HMM: 5-157/159.0
AECAIHDVDCDEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEgcrygqvdtghsyyrDMPSirrSHKDCVFRYMGFPMVDAPTTDISRYFYVASKFID
.| .|. ..  .|.| ...|..  |.... |. ..||.||| .                ..|     ...  ..|.  |. |. . ....|| .| .||.
teadietapasqvlpfLflGsekdaadldaldrlnitavlnvtt...............svPn...efeeealkYkripvsDtskqnlkqyfeealefie

SAISSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRD-IRPNDGFLQQLADLDMELKRKN
 | ..| ..||||  |.||||| |.||||  ...|  || . |. .|  | || .|. || ... ||....
earkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnksk
0036282 (Phosphotyrosine protein) phosphatases II 68-224 4e-28 93.7 In-house 9-166 (174) alignment 
Range on Protein: 68-224
Range on HMM: 9-166/174.0
DVDCDEVYPGIYIGDAAAAkNKTYLRLMGITHVLNAAEGCRYGQVDTGHSYYRdmpsIRRSHKDCVFRYMGFPMVDAPTTDISRyFYVASKFIDSAISS-
..|  .. |....|.. .| .  .|.  |||.|..  | .  | .   . ...     | . .. ...|. .|..|  . |.|  .. . ||...|.|. 
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpe....lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsed

-GGKILVHCLVGMSRSATCVLAYLMICRKM-SAVDAIRTVRMRR----DIRPNDGFLQQLADLD
 ||..||||  | .|..| |.||||..... |.|||...||..|     . ........| ...
pggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
PTEN_1 70-221 5e-27 90.0 In-house 39-185 (196) alignment 
Range on Protein: 70-221
Range on HMM: 39-185/196.0
D-CDEVYPGIYIGDAAAA-KNKTYLRLMGITHVLNAAEGCRYgqvdtghsyyRDMPSIRRSHKDCVFRYMGFPMVDAPTTDISRYFYVASKFIDSAIS--
. ..|. .| |.| .  . ...  |  .|||.|.| .|.. .             .   .....  ..|  ||. | .. ..|. | .. .||....|  
pllqeideglyrgslkdvaadldnlkedgitlvvnlseeeel..........sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdp

SGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRR-DIRPNDGFLQQLA
.|...||||  |..||.| | |||| ..|..| .|.. || .|  ..|| .....| 
ngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerll
subfamily_DSP6_pd Subfamily DSP6 73-229 5.9e-27 88.1 In-house 16-156 (158) alignment 
Range on Protein: 73-229
Range on HMM: 16-156/158.0
EVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEgcrygqvdtghsyyrDMPSIRRSHKDcvFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKILV
|. | .|.| | .|.|   |. ..| .||| ..               ..|.. .....  ..|.  |. |  .......|  | .||| | |.  |.||
eilpllylGsakdasnlevlkklkikyvlnvts...............nlpnkfeesge..lkylqipiedhlsqnlakffPeaiefidearskkskvlv

HCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRR-DIRPNDGFLQQLADLDMELKR
||| |.||| | .|||||  ...|  ||   |..|. .| ||  |..|| | . .|. 
hClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
subfamily_DSP19_pd Subfamily DSP19 134-227 1.2e-26 87.9 In-house 56-150 (152) alignment 
Range on Protein: 134-227
Range on HMM: 56-150/152.0
FRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRR-DIRPNDGFLQQLADLDMEL
| |.  ...| | ||...|.  | .||..| |. | .||||  |.||||. |.||||  ...|  .|...||  |  |.||.||..|| ....||
ftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
0049260 (Phosphotyrosine protein) phosphatases II 74-222 1.9e-26 88.0 In-house 11-144 (152) alignment 
Range on Protein: 74-222
Range on HMM: 11-144/152.0
VYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEGCRYGQVDTGHSYyrdmpsirrshkdcvfRYMGFPMVDAPTTDISRYFYVASKFIDS-AISSGGKILV
. .....|.  .|... .|. .|||....  | .  | . . . .                .|. .|. | .. |.| ... . .||.  |...||..||
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlV

HCLVGMSRSATCVLAYLMIcRKMSAVDAIRTVRMRRD-IRPNDGFLQQLAD
||  |..|..| |.||||. ...|. .|.. ||..|  . || |.|..| .
HCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 78-224 6.4e-26 84.6 In-house 15-144 (148) alignment 
Range on Protein: 78-224
Range on HMM: 15-144/148.0
IYIGDAAAAKNKTYLRLMGITHVLNAAEGCRYGQVDTghsyyrdmpsirrshkdcVFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKILVHCLVG
...|.   | .   |. .|.|.. ||.. ..    .                     .|.  .. | |  |.| .|  . .|.. | . |...|||. .|
LFlGskksaadlealkalgvtrivnatkerdnaldqr..................gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmG

MSRSATCVLAYLMICRKMSAVDAIRTVRM-RRDIRPNDGFLQQLADLD
.|||. ..|..|.  ...|  .|.  |.  || ..|| |||.|||.|.
vsrssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaele
0037934 (Phosphotyrosine protein) phosphatases II 68-225 4.5e-25 84.1 In-house 36-239 (243) alignment 
Range on Protein: 68-225
Range on HMM: 36-239/243.0
DVDCDEVYPGIYIGDA--------AAAKNKTYLRLMGITHVLNAAEGC----------------------RYGQVDTGHSYYRDMPSIRR------SHKD
. .  .|.|.......        ..|..  .|   |||....  | .                      .. .. ....|   . ....      .. .
nanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

CVFRYMGFPMVDAPT--TDISRYFYVASKFIDS-----AISSGGKILVHCLVGMSRSATCVLAYLMICR-KMSAVDAIRTVRMRRD--IRPNDGFLQQLA
. . |...|  ..|.  .|. ...  . .||..     |..|||..||||  | .|..| ..||||. . .... .|....|..|   . .. .....| 
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly

DLDM
.. .
eall
0040439 (Phosphotyrosine protein) phosphatases II 70-227 6.1e-25 83.7 In-house 32-245 (249) alignment 
Range on Protein: 70-227
Range on HMM: 32-245/249.0
DCDEVYPGIYI--------------------GDAAAAKNKTYLRLMGITHVLNAAEGCRYGQ------------------------VDTGHSYYRDMPSI
........ ||                     . . ...  .|.  |||..... . ...|.                        |.. ..|.. .  .
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

RRSHKDCVFRYMGFPMVDAPTTDISRYFYVASKFIDSAIS------SGGKILVHCLVGMSRSATCVLAYLM-----ICRKMSAVDAIRTVRMRR-DIRPN
 .. .. ..........| | .... .|  . .||. . .      .||..||||  |..|..| ..||||       ..... .|....|..|  . .|
tnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

DGFLQQLADLDMEL
......| .. .||
peqyrflyeallel
subfamily_STYX_pd Subfamily STYX 70-224 1e-24 80.5 In-house 11-154 (166) alignment 
Range on Protein: 70-224
Range on HMM: 11-154/166.0
DCDEVYPGIYIGDAAAAK-NK-TYLRLMGITHVLnaaegCRYGQVDTGhsYyrdmpsIRRSHKDcVFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSG
. .|. ||...|  .||.  |  .|.  ||||..     |   ....   .      |.   .|  |||. . . |... .| ||.    .|||.....|
emqeilpglflgpysaamksklevlkkhgithiv.....cirqniean..l......ikpnfpd.rfrylvldvadntveniirylptvkefiddslqkg

GKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRR-DIRPNDGFLQQLADLD
||.|||   |.||||. |.||.|    .   .| . |. ||  | ||.|| .|| . .
gkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeye
0051082 (Phosphotyrosine protein) phosphatases II 70-222 3.3e-24 80.6 In-house 7-148 (151) alignment 
Range on Protein: 70-222
Range on HMM: 7-148/151.0
DCDEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEGCRYGqvdTGHSYYRDMPsirrshkdcvFRYMGFPMVDAPTTDISRYFYVASKFIDSAISS-GG
..  | .|.|....  | .  .|. .||....|  .   .|   . ..|....           .... .|..| |..... .|  . .|.. ...  .|
nfsyvtgglyrsggpladflellkelgiktivnlrseeerg...ycpeylpelg..........ievlhipildwpdpglplsfdavleflellldkkng

KILVHCLVGMSRSATCVLAYLMIcRKMSAVDAIRTVRMRRD--IRPNDGFLQQLAD
..||||  |..|..| |..|||. ...|. .|.. .|..|   ..||..|| || .
pvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
0045450 (Phosphotyrosine protein) phosphatases II 92-228 5.1e-24 81.0 In-house 127-304 (307) alignment 
Range on Protein: 92-228
Range on HMM: 127-304/307.0
LRLMGITHVLNAAEGCRYGQV--------------------------DTGHSYYRDMPSIRRSHKDCVFRYMGFPMVDAPTTDISRYFYVASKFIDSAIS
|.  |.|....  | . .|..                            ..  .| ..  . . .. ... . |.. . | .... .|  . .||. . .
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

------SGGKILVHCLVGMSRSATCVLAYLMICRK--------MSAVDAIRTVRMRR-DIRPNDGFLQQLADLDMELK
      .||..||||  |..|..| ..||||...         ... .|....|..|  . .| .....| .. .|| 
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 78-227 9.9e-24 77.4 In-house 10-152 (154) alignment 
Range on Protein: 78-227
Range on HMM: 10-152/154.0
IYIGDAAAAKNKTYLRLMGITHVLNAAEGCRYgqVDTGHSyyrdmPSIrrsHKDCVFRYMGFPMVDAPTTDISRYFYVASKFIDSAI--SSGGKILVHCL
.||.   || ||  |.|  |...|| . |     . | .        |       .. |.   . | .  || . .  | .|||.||     .|.|||. 
lyissfdaalnkldlqlkniksilnvgiGinn..lftden.....sdi...ndgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsd

VGMSRSATCVLAYLMICRKMSAVDAIRTVRM-RRDIRPNDGFLQQLADLDMEL
 |.||||. ...|||  .|.|   |.  ..  |  |.|| |||.||   . ||
kGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifekel
subfamily_DSP8_pd Subfamily DSP8 67-230 3e-23 76.1 In-house 11-157 (159) alignment 
Range on Protein: 67-230
Range on HMM: 11-157/159.0
HDVDCDEVYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEGCRygqvdtghsyyrDMPSIRRSHkdcvfrYMGFPMVDAPTTDISRYFYVASKFIDSAISS
.||.  .. . .|.|    . ... |. .||..|||| . |             ..  .. |.      ..  |. |  . ... .|  . .||| | |.
advgptrilknlylGsqkdvlseellsklgisyvlnasnscp............kleelkesk......flrvPvkDkydekllpwfdksvefidkakse

GGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRR-DIRPNDGFLQQLADLDMELKRK
 |..|||.| |.||||| ..||.|   .||  .| | |. .|  | ||  ||.|| . . ||| .
ngrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrptispnlnflgqLleyekelkll
0042113 (Phosphotyrosine protein) phosphatases II 69-226 9.5e-23 76.3 In-house 45-241 (245) alignment 
Range on Protein: 69-226
Range on HMM: 45-241/245.0
VDCDEVYPGIYIGDAAAAKNKT----YLRLMGITHVLNAAEGCRYGQVDtGHSYYRDmP-------------------------------SIRRSHKDCV
||.....|....... ....      .|.  |||....  |   .|.|.  . |. .                                     |.....
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvk.caqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevih

FRYMGFPmvDAPTTDISRYFYVASKFIDSAIS--SGGKILVHCLVGMSRSATCVLAYLM-----ICRKMSAVDAIRTVRMRR-DIRPNDGFLQQLADLDM
..|...|  | ...|.....  . .|...|..  |.|..||||  | .|..| ..||||       ...|. .|.. .|..|  ..........| .. .
yhylpwp..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

E
|
e
subfamily_MKPLT_pd Subfamily MKPLT 133-223 5.5e-22 72.0 In-house 65-156 (164) alignment 
Range on Protein: 133-223
Range on HMM: 65-156/164.0
VFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRDI-RPNDGFLQQLADL
.. |.   . | ... .| ..  |.||. .|| |||..||||  | |||... .|.|.  ..    .|   .. || | .|| |||.|||  
sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakf
subfamily_MKPLV_pd Subfamily MKPLV 133-223 5.5e-22 72.0 In-house 65-156 (164) alignment 
Range on Protein: 133-223
Range on HMM: 65-156/164.0
VFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRDI-RPNDGFLQQLADL
.. |.   . | ... .| ..  |.||. .|| |||..||||  | |||... .|.|.  ..    .|   .. || | .|| |||.|||  
sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakf
subfamily_Slingshot_pd Subfamily Slingshot 74-223 1.5e-21 70.5 In-house 22-153 (169) alignment 
Range on Protein: 74-223
Range on HMM: 22-153/169.0
VYPGIYIGDAAAAKNKTYLRLMGITHVLNAAEGCrygqvDtghSYYRDmpsirrshkdcVFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKILVH
..  .|.|    | |   |. .|....|| .. .     |   ... .           .|.|.   . | ..||. .|.  . |||. | ..| |.|||
ifdhvylGsewnasnleelkengveyilnvtkei.....d...nffpe...........kfeylnirvydeeetdllkywnetykfiekakkkgskvlvh

CLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRD-IRPNDGFLQQLADL
| .|.||||. |.|| |   ..|  .|.. |. ||. |.||.|||.||   
ckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleey
subfamily_LRR-DSP_pd Subfamily LRR-DSP 133-231 5.8e-21 68.7 In-house 163-262 (263) alignment 
Range on Protein: 133-231
Range on HMM: 163-262/263.0
VFRYMGF-PMVDAPTTDISRYFYVASKFIDSAISSGGkILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVR-MRRDIRPNDGFLQQLADLDMELKRK
.|.|.    . |..  |||..|     ||..   .|| .||||  |.|||.| |..|||  ...   .|.  |   |  |.|| ||..||   . .|   
lfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklfct

N
|
n
0039614 (Phosphotyrosine protein) phosphatases II 95-230 1.8e-19 65.8 In-house 124-291 (297) alignment 
Range on Protein: 95-230
Range on HMM: 124-291/297.0
MGITHVLNAAEGCRYGQvdTGHSYYRDMPSirRSHKDCV-----------------------------FRYMGFPmvDAPTTDISRYFYVASKFIDSAIS
 |.|....  . . .|.  . ..|. .  .  . .. .|                             | |.|.|  |  . ....... . .....|..
qgvtvivmLtklvelgr..kcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvreala

---SGGKILVHCLVGMSRSATCVLAYLM-----ICRKMSAVDAIRTVRMRR-DIRPNDGFLQQLADLDMELKRK
   .||..||||  | .|..| ..||||       ..... .|....|..|  ..........| |. .|| ..
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkr
0036941 (Phosphotyrosine protein) phosphatases II 97-232 2.6e-19 65.1 In-house 103-281 (297) alignment 
Range on Protein: 97-232
Range on HMM: 103-281/297.0
ITHVLNAAE--------GCRYGQVDTGHSYYRDMPSIRRSHKDC-------------------------VFRYMGFPMVDAPTtdisrYFYVASKFIDSA
.|....  |         ..|   ..|.|.. .  ...  . .                          .| |.| |  ..|.     ...   .||. .
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpe.....spaslldfielv

IS------SGGKILVHCLVGMSRSATCVLAYLM--------ICRKMSAVDAIRTVRMRR-DIRPNDGFLQQLADLDMELKRKNL
 .      |||..||||  | .||.| ..|.||        . .... ..|....|..|  . .. .....| .. .|| .|.|
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0038934 (Phosphotyrosine protein) phosphatases II 130-220 4.1e-19 64.4 In-house 76-169 (194) alignment 
Range on Protein: 130-220
Range on HMM: 76-169/194.0
KDCVFRYMGFPMVD---APTTDISRYFYVASKFIDSAiSSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRR-DIRPNDGFLQQL
..  ..|. .|..|   .|...| . |. . ... .. ..||...|||  |..|..| | |||. ...||| .||...|..| .. || ..|..|
ekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleal
0040438 (Phosphotyrosine protein) phosphatases II 130-229 2.8e-17 58.4 In-house 152-277 (317) alignment 
Range on Protein: 130-229
Range on HMM: 152-277/317.0
KDCVFRYMGFPMVDA----------------PTTDISRYFYVASKFIDSAISS----GGKILVHCLVGMSRSATCVLAYLM-----ICRKMSAVDAIRTV
..  . .  ....|                 |  ..  ..    .|.. . ..    ||..||||  | .|..| ..||||       ..... .|....
elagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkel

RMRRD-IRPNDGFLQQLADLDMELKR
|..|  . .. .....| |. .|. .
reqRpgavqtpeqyrflydalleylk
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 78-230 7.3e-17 54.8 In-house 6-144 (145) alignment 
Range on Protein: 78-230
Range on HMM: 6-144/145.0
IYIGDAAAAKNKTYLRLMGITHVLNAAEGCrygQVDTGHSYYRDMPSIRrshkdcvfrymgFPMVDAPTTDISRYFYVASKFIDSAISSGGKILVHCLVG
.|.| |  |.. . |. .||. ..| | |     | . ... ...  .                 |  . |.|..|   . |||     |  ..|||. |
lyvgsalhandvptlqelgisrivnmaags...lvasqelksesieill............itaedlesydlsqhfdevtdfidkgkeegagvfvhcmag

MSRSATCVLAYLMICRKMSAVDAIRTVRMRR-DIRPNDGFLQQLADLDMELKRK
.||| |  .|.||   .|.  .| | || .|    ||  ||..| .|. .||..
vsrsvtvsvaflmkycnmtlseaarqvrsnrllaypnvtflknllnlekqlkee
0043336 (Phosphotyrosine protein) phosphatases II 127-223 8.4e-17 57.0 In-house 171-272 (278) alignment 
Range on Protein: 127-223
Range on HMM: 171-272/278.0
RSHKDCVFRYMGFPMVDAPTtDISRYFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLM-----ICRKMSAVDAIRTVRMRR-DIRPNDGFLQQL
 |.. ... |.|.|  ..|. ..| ..    ....   .|.|..||||  | .|..| ...||.       ..... .|....|..|  . ... ....|
esrtvthyhylgwpdhgvpe.slsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl

ADL
 ..
yea
subfamily_STYXL1_pd Subfamily STYXL1 73-225 2.9e-16 53.1 In-house 13-151 (157) alignment 
Range on Protein: 73-225
Range on HMM: 13-151/157.0
EVYPG-IYIGDAAAAKNKTYLRLMGITHVLNAAEGCRYgqvdtghsyyrdmpsIRRSHKDcVFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKIL
|| || .|.|.   |.|..  . . .  ..| .  .                 .  . .| | . .  .. | . .|.   .  | .||..   .|  .|
evlPgklylGnykqaqnpaikkdlkvkahvnvsmdadk...............liagvad.vakllhiavedeneadllerlkeavqfiekhkkegevvl

VHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRM-RRDIRPNDGFLQQLADLDM
|    |.||||. ..||||  .|..  .|   ..  . ...|| .|..|| . . 
vfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWek
0051429 (Phosphotyrosine protein) phosphatases II 73-227 1.2e-15 53.4 In-house 18-224 (272) alignment 
Range on Protein: 73-227
Range on HMM: 18-224/272.0
EVYPG-IYIGDAA---AAKNKTYLRLMGITHVLNAAEGCRYGQVDTGHS--------------YYRDMP----------------------------SIR
.| || .| ...     |..  .|. .||.....  . . .|....                 .. ..                             |  
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

RSHKDCVFRYMGFPMVDAPTTDISRYFYVASKfidsaissGGKILVHCLVGMSRSATCVLAYLMIcRKMS--------------AVDAIRTVRMRR-DIR
 ...  .. |...|   .|.  . . . .  .        ||..||||  |..|..| |...|.. . .|              . .|.. .| .|  ..
earevmhlhytdwpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgav

PNDGFLQQLADLDMEL
........| .  .||
qteeqylflyeallel
0047943 (Phosphotyrosine protein) phosphatases II 126-208 5.1e-14 47.8 In-house 163-251 (273) alignment 
Range on Protein: 126-208
Range on HMM: 163-251/273.0
RRSHKDCVFRYMGFPMVDAP-TTDISRYFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLM-----ICRKMSAVDAIRTVRMRR
  |.. ..| |.|.|  ..| ....   |. . . . .|. |.|...|||  | .|..| ....|.       ..... .|.. .|..|
gesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqR
0046845 (Phosphotyrosine protein) phosphatases II 127-208 7.3e-14 47.3 In-house 163-253 (284) alignment 
Range on Protein: 127-208
Range on HMM: 163-253/284.0
RSHKDCVFRYMGFPMVDAP--TTDISRYFYVASKFIDSaISSGGKILVHCLVGMSRSATCVLAYLMICR--------KMSAVDAIRTVRMRR
 |..  .| |...|  ..|  ..|. ...  . ..... ...||.|.|||  |..|..| ....|....        .... .|.. .|..|
esrtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR
subfamily_MSG5_pd Subfamily MSG5 155-230 2.4e-13 43.5 In-house 87-163 (165) alignment 
Range on Protein: 155-230
Range on HMM: 87-163/165.0
VASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMR-RDIRPNDGFLQQLADLDMELKRK
  .. | .| | . ||||||  |.||||. ..||.|   ..|  ||   .. .  || |. |.. || . .. |..|
rltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk
0051299 (Phosphotyrosine protein) phosphatases II 128-213 4.8e-13 44.7 In-house 181-267 (288) alignment 
Range on Protein: 128-213
Range on HMM: 181-267/288.0
SHKDCVFRYMGFPMVDAPTtDISRYFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICR--KMSAVDAIRTVRMRRDIRPN
|..  .| |...|  ..|. ... ..    .....  |.|| ..|||  | .|..| ....|....  |   ||. ..|.. |  ||.
srtvthfhytnwpdhgvpd.spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpg
subfamily_PTPMT1_pd Subfamily PTPMT1 137-210 1.7e-12 42.1 In-house 77-150 (171) alignment 
Range on Protein: 137-210
Range on HMM: 77-150/171.0
MGFPMVDAPTTDISRYFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRRDI
. ...||   .        . .||.. .|.| .. |||  | .|||| | .|||  .|.|  .|..... .|.|
lqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRki
0050432 (Phosphotyrosine protein) phosphatases II 127-208 1.5e-11 39.6 In-house 195-278 (308) alignment 
Range on Protein: 127-208
Range on HMM: 195-278/308.0
RSHKDCVFRYMGFPMVDAPT--TDISRYFYVASKFIdsaisSGGKILVHCLVGMSRSATCVLAYLM-----ICRKMSAVDAIRTVRMRR
 |..  .| |.. |  ..|.  ... ...  . |..     .||.|.|||  | .|..| ....|.       ..... .|....|..|
esrtvthfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR
0048567 (Phosphotyrosine protein) phosphatases II 134-208 1.9e-11 38.5 In-house 39-118 (157) alignment 
Range on Protein: 134-208
Range on HMM: 39-118/157.0
FRYMGFPMVDAPTT--DISRYFYVASKFIDSAISSGGKILVHCLVGM---SRSATCVLAYLMICRKMSAVDAIRTVRMRR
. |. | . . | .   . |..... ||...    |..| |||  |.   .|.|| . .||... .... .||. .|. |
lvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr
subfamily_PTPDC1_pd Subfamily PTPDC1 97-208 2.1e-11 38.6 In-house 47-155 (182) alignment 
Range on Protein: 97-208
Range on HMM: 47-155/182.0
ITHVLNAAE-----GCRYGQVDTGHSYYRDmpSIRRshKDcVFrYMGFPMVDAPTTDISRYFYVaSKFIDSAISSGgKILVHCLVGMSRSATCVLAYLMI
|. |.|  |      | .|. ..| ||  .  .. .  .. .. .. |.. |  .. . | . .  | ...|.. | |. |||  |. |    . .||. 
ikavinLqekgehasCGagleesGfsYdle..alme..qg.iy.vynfgwkDygvasleriLdi.vkvvafalqeg.kvavhChaGlGrtGvliacylvy

CRKMSAVDAIRTVRMRR
 ....| .||..|| .|
akrltaekaiklvrskr
subfamily_DSP23_pd Subfamily DSP23 158-208 6.2e-09 30.7 In-house 75-125 (148) alignment 
Range on Protein: 158-208
Range on HMM: 75-125/148.0
KFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRR
. .. | . .  . |||| |. |. | .  ||.  ||..| .||  || .|
rvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr
PTPc_DSPc_SM00012 134-212 2.9e-08 29.2 In-house 5-87 (105) alignment 
Range on Protein: 134-212
Range on HMM: 5-87/105.0
FRYMGFPMVDAPT--TDISRYFYVASKFIDSAISsGGKILVHCLVGMSRSATCVLAYLMICRKMSA---VDAIRTVRMRRDIRP
. |.| |   .|.  ..| ...    |.   . | .. ..|||  | .|..| |........ ..    ||  ..|.. |. ||
yhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRp
subfamily_Laforin_pd Subfamily Laforin 74-194 2.1e-07 24.0 In-house 14-137 (183) alignment 
Range on Protein: 74-194
Range on HMM: 14-137/183.0
VYPGIYIGDAAAAKNKT-YLRLMGITHVLNAAEGCRYGQVDTGHS-YYRDMPS-IRRSHKDCVFRYMGFPMVDAPTTDISRYFYVASKFIDSAISSGGKI
... |..|     ...   |.  ||| |..        .  .|   | ...|  ... .|.  . |. .|. |  |    . .  |  .. . .  | ..
ileniwlgscprlvehvidlksegitavislqtesdivknssgiyrynenlpitlkklykeeglayiwlptedlstesrvenlpqavyllhallekghiv

LVHCLVGMSRSATCVLAYLMICRK
 |||  |. ||.. |  .|.   .
yvhcnagvgrstaivcgflqyvlg
subfamily_CDC14_pd Subfamily CDC14 155-208 2.8e-07 24.7 In-house 251-304 (328) alignment 
Range on Protein: 155-208
Range on HMM: 251-304/328.0
VASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICRKMSAVDAIRTVRMRR
.  ||.. | .. |.| |||  |. |  | . .|||   ...| .||  .|. |
ivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricr
Y_phosphatase Protein-tyrosine phosphatase 133-212 2.7e-06 22.3 Pfam-A 137-217 (235) alignment 
Range on Protein: 133-212
Range on HMM: 137-217/235.0
VFRYMGFPMVDAPtTDISRYFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICRKMS--AVDAIRTVRMRRDIRP
.. | . |  ..| .. .  . .  |.  |  .. |...|||  |..|..| |.. .....  .   ||   .|.. |  ||
qlhytnWpdhgvp.espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
Y_phosphatase Protein-tyrosine phosphatase 133-212 2.7e-06 22.3 In-house 137-217 (235) alignment 
Range on Protein: 133-212
Range on HMM: 137-217/235.0
VFRYMGFPMVDAPtTDISRYFYVASKFIDSAISSGGKILVHCLVGMSRSATCVLAYLMICRKMS--AVDAIRTVRMRRDIRP
.. | . |  ..| .. .  . .  |.  |  .. |...|||  |..|..| |.. .....  .   ||   .|.. |  ||
qlhytnWpdhgvp.espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRp
subfamily_PTPRK_pd Subfamily PTPRK 133-213 9.2e-06 19.7 In-house 177-258 (314) alignment 
Range on Protein: 133-213
Range on HMM: 177-258/314.0
VFRYMGFPMVDAPTTDISRYFYVAsKFIDSAISSGGKILVHCLVGMSRSATCVLAYLM--ICRKMSAVDAIRTVRMRRDIRPN
 |...|.|. | |.   .   .|. .   |   . |.|.|||. |  |. | .    .  . .. . ||   .|.  |. ..|
qfqflgWpdhdvPvsatgllklvr.rvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvn