Gene Mkp3 in Drosophila melanogaster

Synonym: CG14080, CG14081, DMKP-3, Dmel\CG14080, Dmkp3, MKP3, mkp-3, mkp3, Dmel_CG14080, Mkp3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP022_AA protein Get Run
DmelP022_AA_212-359 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP6_pd Subfamily DSP6 203-359 6.8e-78 253.6 In-house 2-157 (158) alignment
Range on Protein: 203-359
Range on HMM: 2-157/158.0
HHHHSHHNYNEAPVEIIPgLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHC
..........|.||||.| ||.||.|......|.|||..||||||||..|||||.|||..|||||||.||.||.|| .||.||.||.||||..| |||||
eedklkkaeaefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhC

LAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLR
|||.||||||||||||... ||||||...|..||...||||.||.|||.||..|||.
laGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls

subfamily_DSP10_pd Subfamily DSP10 210-357 5.9e-52 169.7 In-house 8-154 (159) alignment
Range on Protein: 210-357
Range on HMM: 8-154/159.0
NYNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKEsGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRS
....||.  .   ||||... . | .||...||..|||||...||.|.|  ..|| .||..| ..|.|  .| .|..||||||. .| ||||| ||.|||
dietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrs

VTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
.||..||||. ..||||||. .|....| .|||. || ||| || .|.
atvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln

0044763 (Phosphotyrosine protein) phosphatases II 214-358 6.8e-43 141.7 In-house 22-172 (178) alignment
Range on Protein: 214-358
Range on HMM: 22-172/178.0
APVEIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPDL-------PNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEAR-SASSVVLVHCLAG
 ..||.|| |.||.. ...| | ||...|....|.|..|       . .. |. .|.||.||| ||  .||  ||.....|||||. .  ..||||| ||
naseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

VSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPdVSPNFHFMQQLLSFESQLRL
|.|| |. .||||...||||..|...|| |.| ..||.....||. ||..|. 
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk

subfamily_DSP1_pd Subfamily DSP1 208-357 5e-42 137.8 In-house 12-157 (163) alignment
Range on Protein: 208-357
Range on HMM: 12-157/163.0
HHNYNeaPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKEsgDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVS
.. |.  |||.|   |.|| .|.. . | ||. .|  .|||. .|.| |..    .| .... |. ..|.  .| ..|.||.|....   ||.|| ||.|
lklyd..PvekildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGis

RSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
|| |. |||||.|. .||..|| .|..|.. .|||. |..|||..|..| 
RsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll

PTPc_motif_SM00404 215-354 9.3e-42 137.2 In-house 2-139 (140) alignment
Range on Protein: 215-354
Range on HMM: 2-139/140.0
PVEIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKfKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTL
| .| |. |.||..... ... |||..|..|.|||   ... ||  ....||||. |. ...|. ... ...|||.|..    ||||| ||||||.|...
psrilph.lylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatlii

AYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
||||..|.|||..|. .|..|.| .|||..|..||...| 
aYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek

DSPc Dual specificity phosphatase, catalytic domain 223-354 1.3e-40 133.3 Pfam-A 1-132 (133) alignment
Range on Protein: 223-354
Range on HMM: 1-132/133.0
LFLGNATHSCdSEALKKYNIKYVLNVTPDLPN-KFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTR
|.||.....   . |.|..|..|.|||   || .... ..|.||.||. |. ..... ....|..|||.|..    ||||| ||.||| |...|||| |.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
.||||.|...|..|.. .|||..|..|||..|.
nlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 223-354 1.3e-40 133.3 In-house 1-132 (133) alignment
Range on Protein: 223-354
Range on HMM: 1-132/133.0
LFLGNATHSCdSEALKKYNIKYVLNVTPDLPN-KFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTR
|.||.....   . |.|..|..|.|||   || .... ..|.||.||. |. ..... ....|..|||.|..    ||||| ||.||| |...|||| |.
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
.||||.|...|..|.. .|||..|..|||..|.
nlslneAyefvkerrskispnagflrqLleyer

0048179 (Phosphotyrosine protein) phosphatases II 215-356 1.1e-39 130.7 In-house 4-144 (144) alignment
Range on Protein: 215-356
Range on HMM: 4-144/144.0
PVEIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTL
|.||.|| |.||.  ...| | |||..|..|.|.|.. .. | |   |.||..|. ||   ||. .......|||||.. . .||||| |||.|. |. .
pseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

AYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
||||...||||..|.|.|| | | . ||......|| .|..|
aylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll

subfamily_DSP8_pd Subfamily DSP8 215-358 4.6e-39 127.5 In-house 15-156 (159) alignment
Range on Protein: 215-358
Range on HMM: 15-156/159.0
PVEIIPgLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNkFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTL
| .|..  |.||  ... ..|.|.|..| ||||.    |.  .|  . |.|..|. |.|. .|   |. ...||. |.|... ||||.||| ||| || .
ptrilk.nlylGsqkdvlseellsklgisyvlnasnscpk.leelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRL
||.|.|  .||..|.  |....| .|||. |..||| .| .|.|
ayimktlemsldeayrfvkekrptispnlnflgqLleyekelkl

subfamily_DSP19_pd Subfamily DSP19 214-356 5.6e-39 127.9 In-house 10-150 (152) alignment
Range on Protein: 214-356
Range on HMM: 10-150/152.0
APVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKEsgDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVT
  |  .   |.||      |.|.||. .| ..|||. ..|| | .  |..||.|.| |.  .||  ....|..|||||||.  .||||| ||||||..| 
levgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpk..dftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv

LAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
.||||... |||..|. .||. .| ..||  |..|| ..|..|
iaylmkkeelsleealelvrearpcikPneGFikqLkeyeael

0048076 (Phosphotyrosine protein) phosphatases II 215-356 1.9e-38 126.7 In-house 4-142 (145) alignment
Range on Protein: 215-356
Range on HMM: 4-142/145.0
PVEIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKEsgDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTL
| ||.|| |.||. .. .| | ||...|..|||.|..|.. ...  .|.||..|. ||  .||. .......|||||...  .||||| |||.|. |. .
pseilpg.lylgslptaldlellkdlgittvlnltselellerl..giqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlva

AYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
||||...|.|| .|...|| . | . ||......|. || .|
aylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel

subfamily_DSP12_pd Subfamily DSP12 218-354 5.9e-38 124.7 In-house 5-141 (155) alignment
Range on Protein: 218-354
Range on HMM: 5-141/155.0
IIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPD-LPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAY
| || |.||....  . | ||...|. || |.   ||.  .. | .....|.|.|. ..|.  |...|..|||||..    ||||| ||||||||. .||
ilpg.lylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
||.. .|||..|. .|.. ||...||  |..||  || 
lmkkeklslekAlklvkekkpeiepNegFleQLklfek

0043147 (Phosphotyrosine protein) phosphatases II 201-359 9.6e-38 125.0 In-house 5-163 (172) alignment
Range on Protein: 201-359
Range on HMM: 5-163/172.0
HHHHHHSHHNYNEAPVEIIPGLLFlGNATHSCDSEALKKYNIKYVLNVTPD-LPNKFKESGDIKYLQIPITDHYSQdLAIHFPDAIQFIEE--ARSASSV
..  . |. ...  | ..|...   .. |.. . . ||...|....|.|.  .. .. |  .|.|| .|. ||  . |. .......||.|  |.| . .
sdyinasyldlyyipdrfiatqgp.lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggp

VLVHCLAGVSRSVTVTLAYLMHtRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLR
||||| |||.|..|. .||||. .|||| .|.|.||...| ...|......|. ||..|.|.
vlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllll

subfamily_DSP14_pd Subfamily DSP14 219-357 2.7e-37 122.1 In-house 10-145 (157) alignment
Range on Protein: 219-357
Range on HMM: 10-145/157.0
IPGLLFLGnATHSCDSEALKKYNIKYVLNVTPDLPNkfKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLM
|   |||. .. . . |.|||..|  ..|||..|||  ..  ||.....|..|. ...|| ||  ... |||.. .   .|||| |||||| ...|||||
itpsLfls.gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
... |||..|. .|....| ..||  | .|| ..|..|.
kyeklsLreayklvksaRpiirPNvGFwkqlidyEkklk

subfamily_DSP15_pd Subfamily DSP15 217-354 1.3e-34 113.5 In-house 4-137 (151) alignment
Range on Protein: 217-354
Range on HMM: 4-137/151.0
EIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPdlpNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAY
...|| |.||| . | |.| ||. ||  .|.|     |. |   ||.|. |...|  |..|  .| ....|| ..|.    ||||||||||||||.. ||
kvlpg.lylgnfrdskdeelLkeknithilsvhd...nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaY

LMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
||    |. .||. ... ..    ||| | .|| ..| 
lmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek

0049260 (Phosphotyrosine protein) phosphatases II 221-356 2.5e-34 113.5 In-house 13-149 (152) alignment
Range on Protein: 221-356
Range on HMM: 13-149/152.0
GLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPN-KFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEE-ARSASSVVLVHCLAGVSRSVTVTLAYLM
. ...|. |.. . . ||...|......| .|.. |.|.   |.||..|. ||. .||.........|||. |.. . .||||| |||.|. |. .||||
atqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

HtRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
. .|.|| .|.|.|| ..| . ||......|. ||..|
l.lgvsleeavalvrekRpgavpnpgqlrflyefekll

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 214-354 2.9e-34 111.7 In-house 6-145 (148) alignment
Range on Protein: 214-354
Range on HMM: 6-145/148.0
APVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGdIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVT
 | || .. ||||.  .  | ||||. ..  . | | . .| . . | |.||.... |.  .||   |.|.|.|...|...   ||||.  |||||  ..
fpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrg.ieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssala

LAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
|..|....  ||..|.|.|..... | ||  |..||  .| 
llwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq

PTEN_1 216-357 1e-33 111.8 In-house 42-192 (196) alignment
Range on Protein: 216-357
Range on HMM: 42-192/196.0
VeIIPGLLFLGNATHS-CDSEALKKYNIKYVLNVTPDLPN-------KFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASS--VVLVHCLAG
   |.. |..|....  .| . ||. .|  |.|.... ..       .. . ....||..||.||  ..|. .|  . .||| ..|...  |||||| ||
q.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaG

VSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
..||.||  ||||....|. ..|...||.. | ..||  ....|| ....|.
lgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaell

0041856 (Phosphotyrosine protein) phosphatases II 214-356 4e-33 109.9 In-house 18-172 (182) alignment
Range on Protein: 214-356
Range on HMM: 18-172/182.0
APVEIIPGlLFLGNATH--------------SCDSEALKKYNIKYVLNVTPDL--PNKFKESGdIKYLQIPITDHYSQDlaihFPDAIQFIEEARSASSV
 . .| .. |.||.  .               .. . ||...|....|.|..|  |....  | |.||..|. ||   |    ......||||... . .
dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlg.iqylylpwpDhgvpd....ldelldfieevleeggp

VLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKP--DVSPNFHFMQQLLSFESQL
||||| |||.|. |. .||||...|.|| .|...|| |.|   ..||..|. ||. .| .|
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll

0049772 (Phosphotyrosine protein) phosphatases II 223-356 1.1e-32 109.4 In-house 155-273 (314) alignment
Range on Protein: 223-356
Range on HMM: 155-273/314.0
LflgNATHSCDSEALKkynikyvlnvtP-DL-PNKFKESGdIKYLQIPITDhYSQDLAIHFPDAIQFIEEArSASSVVLVHCLAGVSRSVT-VTLAYLMH
    |  . .| | ||           .    |..|.. | ||||.||..| .|..|  .|.....||||| .. ..||||| ||..|. | |..||||.
g...neptaadlellk...........eelydpelferlg.ikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmk

TRGLSLNDAFAMVRDRKPdVSPNFHFMQQLLSFESQL
 .|.||..|...|| . | ..||..|..||. .| .|
llgvsleealedvrlkRp.inpnpgfieqleqyefil

subfamily_STYXL1_pd Subfamily STYXL1 211-356 1.3e-32 106.2 In-house 7-153 (157) alignment
Range on Protein: 211-356
Range on HMM: 7-153/157.0
YNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESGD-IKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRS
... |||..|| |.|||  .... .  |   .| ..||. |  . ..   |  | |.|.. |.   ||  .. .|.||||. .  ..||||    |.|||
lktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrs

VTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
..| .||||. . ..|..|.. ... |..| ||  |..||  .| ||
aaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql

subfamily_Slingshot_pd Subfamily Slingshot 220-356 1.5e-32 106.3 In-house 23-157 (169) alignment
Range on Protein: 220-356
Range on HMM: 23-157/169.0
PGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKEsgDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMH
   ..||    ... | ||. ...|.|||| .. | |.|  ...||.| . |. ..||  .. .. .|||.|... | |||||  ||||| .. .|| |.
fdhvylGsewnasnleelkengveyilnvtkeidnffpe..kfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamk

TRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
. ||||..|.. |..|.  . ||  |..||  .|  |
eyglsleealeyvkerrsvikPnkgflkqleeyeGil

0046846 (Phosphotyrosine protein) phosphatases II 211-357 1.9e-31 104.6 In-house 8-173 (176) alignment
Range on Protein: 211-357
Range on HMM: 8-173/176.0
YNEAPVEIIPGLLFLGNA---------THSCDSEALKKYNIKYVLNVTPDL-------PN--KFKESGDIKYLQIPITDHYSQDLaIHFPDAIQFIEEAR
... ...|...|.. .           |.  . | ||...|..|.|.| .        ||  .  |. .|.||..|. ||   ||  .......||.||.
ldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefireal

SASSVVLVHCLAGVSRSVTVTLAYLMHT-RGLSLNDAFAMVRDRKP-DVSPNFHFMQQLLSFESQLR
..  .||||| ||..|. |. .|||... .|||...|.|.||...|  . ........|  || .|.
keggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellll

0036282 (Phosphotyrosine protein) phosphatases II 208-356 2.5e-31 104.1 In-house 4-169 (174) alignment
Range on Protein: 208-356
Range on HMM: 4-169/174.0
HHNYNEAPVEIIPGLLFLGNATHScDSEALKKYNIKYVLNVTPDLPN-------------KFKESGDIKYLQIPITDHYSQDLAIhFPDAIQFIEEARSA
 .|..   . .|.. |..|.. .. . | ||...|..|.....  ..             .. |  .|.||..|. ||   ||.| . ....|.|||.| 
yinaspldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse

--SSVVLVHCLAGVSRSVTVTLAYLMHTRGL-SLNDAFAMVRDRK---PDVSPNFHFMQQLLSFESQL
  . .||||| |||.|. |. .||||....| || ||...|| ..   | . ........|  ||..|
dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll

subfamily_DSP3_pd Subfamily DSP3 217-357 1.9e-30 99.7 In-house 13-158 (162) alignment
Range on Protein: 217-357
Range on HMM: 13-158/162.0
EIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPD------LPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSA-SSVVLVHCLAGVSRS
|. |. |..|... . | . |||  | .||| .          ..| .  .|||| ....|  . ||  .|  | .||.|| |  .. ||||| .|||||
evypk.lyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRs

VTVTLAYLMHTRGLSLNDAFAMVRDRKpDVSPNFHFMQQLLSFESQLR
 |. ||||| .| ..|..|   ||... .. ||  |..|| .....|.
atlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelk

subfamily_MKPLT_pd Subfamily MKPLT 211-354 9.6e-30 97.3 In-house 17-158 (164) alignment
Range on Protein: 211-354
Range on HMM: 17-158/164.0
YNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESgdIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSV
..  |  ...  |.|||| |. . . ||. .|....||. .  ..| .|  ..|||. . |   . |. ..  | .|. .|  .   |||||  |.||| 
ikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrss

TVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
.||.|.|.. .|  |..|.  ...|.  |.||  |..||  || 
svtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_MKPLV_pd Subfamily MKPLV 211-354 9.6e-30 97.3 In-house 17-158 (164) alignment
Range on Protein: 211-354
Range on HMM: 17-158/164.0
YNEAPVEIIPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESgdIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSV
..  |  ...  |.|||| |. . . ||. .|....||. .  ..| .|  ..|||. . |   . |. ..  | .|. .|  .   |||||  |.||| 
ikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrss

TVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
.||.|.|.. .|  |..|.  ...|.  |.||  |..||  || 
svtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee

0045098 (Phosphotyrosine protein) phosphatases II 220-358 4.4e-29 97.1 In-house 26-273 (278) alignment
Range on Protein: 220-358
Range on HMM: 26-273/278.0
PGLLFLGNAT-----------------------------------------HSCDSEALKKYNIKYVLNVTPDLPN------------------------
   |.|||.                                          .. . . |....|......|. ...                        
tpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtl

-----------------------KFKESGDIKYLQI-PITDHYSQDLA--IHFPDAIQFIEEARS--------------ASSVVLVHCLAGVSRSVTVTL
                       .  ||  ...|.. |. || . .|    .| ....||.||..               . .||||| |||.|. |. .
lseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlva

AYLMHTR---GLSLNDAFAMVRDRKPD-VSPNFHFMQQLLSFESQLRL
|||| ..   |..| .|....| ..|  . .|......|  |. .|.|
aylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll

0040439 (Phosphotyrosine protein) phosphatases II 229-357 2.3e-28 94.9 In-house 66-246 (249) alignment
Range on Protein: 229-357
Range on HMM: 66-246/249.0
THSCDSEALKKYNIKYVLNVTPDLPNKF-----------------------------------------KESGDIKYLQIPITDHYSQDLAIHFPDAIQF
| . . . |....|......|.. ....                                         ... ....|.|..||   ...  .|.|...|
tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldf

IEEARS------ASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
||..|.       ...||||| |||.|. |. .||||     ...|..| .|....|...| . .|......|. .. .|.
ieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0042113 (Phosphotyrosine protein) phosphatases II 206-355 7.1e-28 93.1 In-house 37-241 (245) alignment
Range on Protein: 206-355
Range on HMM: 37-241/245.0
HSHHNYNEAPVEIIPGLLFLGNATHSCDSE----ALKKYNIKYVLNVTPDLP--------------------------------------------NKFK
..  | .  ..  |.. ...... .. . |     |....|......|.. .                                             ...
sdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgdde

ESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARS--ASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLL
.  .| |...|. ||   ||  .. |...|...|..  .. .||||| |||.|. |. .||||     ...|.|| .|....|...| . ........| 
srevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfly

SFESQ
 .. .
ealle

0037934 (Phosphotyrosine protein) phosphatases II 211-356 3.6e-27 90.9 In-house 35-241 (243) alignment
Range on Protein: 211-356
Range on HMM: 35-241/243.0
YNEAPVEIIPGlLFLGNA--------THSCDSEALKKYNIKYVLNVTPDL------------------------------------------PN-KFKES
.|   ... |. |.....        ..  . . |....|......|..                                           .. .  . 
inanliyvtpr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltr

GDIKYLQIPITDH---Y-SQDLAIHFPDAIQFIEE-----ARSASSVVLVHCLAGVSRSVTVTLAYLMHTR-GLSLNDAFAMVRDRKPD-VSPNFHFMQQ
 .|.|...|. ||      .||  .. ....||||     |.. ...||||| |||.|. |. .||||... |..| .|....|...|  . ........
lvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrf

LLSFESQL
|  .. .|
lyeallel

0051082 (Phosphotyrosine protein) phosphatases II 219-350 6.9e-27 89.3 In-house 11-147 (151) alignment
Range on Protein: 219-350
Range on HMM: 11-147/151.0
IPGLLFLGNATHSCDSEALKKYNIKYVLNVTPDL-----PNKFKESGdIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSA-SSVVLVHCLAGVSRSVTV
. | |..... .. . | ||...||...|....      |. ..| | |..|.|||.|.  ..| ..|. ...|.|....  . .||||| ||..|. |.
vtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

TLAYLMHtRGLSLNDAFAMVRDRKP-DVSPNFHFMQQLL
 ..|||. .|.||..|....| . |  | || .|. ||.
valylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf

subfamily_LRR-DSP_pd Subfamily LRR-DSP 214-356 7.1e-27 88.1 In-house 119-258 (263) alignment
Range on Protein: 214-356
Range on HMM: 119-258/263.0
APVEIIPGlLFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKESgdIKYLQI-PITDHYSQDLAIHFPDAIQFIEEARSAsSVVLVHCLAGVSRSVTV
 | |||.. ||||    . .   ||. .. ..|    |.   | .    ||| |  | |    |.  || .   |||| |     ||||| |||||| |.
vPdeiidk.lflGgldsannksilkdlgvthillavadfePlfPkl..fkylsiddiedvdeadisqhfeetnafieeGrkk.GGvlvhcraGvsrsstl

TLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
...|||. . | ...|. .|  ..| . ||  |..||. .| .|
visylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl

0045450 (Phosphotyrosine protein) phosphatases II 235-356 1.6e-26 89.2 In-house 125-303 (307) alignment
Range on Protein: 235-356
Range on HMM: 125-303/307.0
EALKKYNIKYVLNVTPDLPNKF--------------------------KESGDIKYLQIPITDH-----------------YSQDLAIHFPDAIQFIEEA
. |...........|.. ....                          .. ..........||.                   ...  .| ....||||.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RS------ASSVVLVHCLAGVSRSVTVTLAYLMHTRG--------LSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
|.       ...||||| |||.|. |. .|||| ...        ..| .|....|...| . .|......|  .. .|
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 223-357 2e-25 82.9 In-house 10-153 (154) alignment
Range on Protein: 223-357
Range on HMM: 10-153/154.0
LFLGNATHSCDSEALKKYNIKYVLNVTPDLPNKFKES-GD------IKYLQIPITDHYSQDLAIHFPDAIQFIEEAR--SASSVVLVHCLAGVSRSVTVT
|...    . .   |...||| .|||    .| | .   |      |.||.. . |.  .|.  ..  | .||..|      . ||||. .||||| .. 
lyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaall

LAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
..|||. . .||  |. ...| .. ..||  |..||  || .|.
isylmdklkislslalellkdsryiikPnqGflkqleifekell

0039614 (Phosphotyrosine protein) phosphatases II 236-358 1.1e-24 82.8 In-house 120-290 (297) alignment
Range on Protein: 236-358
Range on HMM: 120-290/297.0
ALKKYNIKYVLNVTPDLPN-----------------------KFKESGDIK-----------------YLQIPITDHYSQDLAIHFPDAIQFIEEARS--
 ............|.  ..                       |... ....                 .. ... ||   ... .. .......||..  
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-ASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRL
  . .||||| |||.|. |. .||||     ...|... .|....| ..| . ........|  .. .|..
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 223-357 1.6e-24 79.6 In-house 6-142 (145) alignment
Range on Protein: 223-357
Range on HMM: 6-142/145.0
LFLGNATHSCDSEALKKYNIKYVLNVT--PDLPNKFKESGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHT
|. | | |. |. .|..  |  ..|..    .  .   | .|. | |   |  | ||. || .  .||.  .   . |.|||.|||||||||..|.||. 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

RGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLR
 ...| .|   || ..    || .|...|| .| ||.
cnmtlseaarqvrsnrllaypnvtflknllnlekqlk

0038934 (Phosphotyrosine protein) phosphatases II 240-357 1.6e-24 82.1 In-house 55-177 (194) alignment
Range on Protein: 240-357
Range on HMM: 55-177/194.0
YNIKYVLNVT---PDLPNKFKESGDIKYLQIPITDHY---SQDLAIHFPDAIQFIEEArSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVR
... .|...|   .    .  |. .|.||..|. |..   |...  .| |..... .. ... ||.||| ||..|. |.  |||....|.|...| |..|
vklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfr

DRKPDVSPNFHFMQQLLSFESQLR
...|.. || .....||.. ..||
ekRpgaipnqdyleallkrykelr

0040438 (Phosphotyrosine protein) phosphatases II 236-359 7e-24 80.1 In-house 105-278 (317) alignment
Range on Protein: 236-359
Range on HMM: 105-278/317.0
ALKKYNIKYVLNVTPDLPNK-------------------------FKESGDIKYLQIPITDH----------------YSQDLAIHFPDAIQFIEEARSA
 ............|.  ...                         ..| ..|........|.                  ...  .. . ..|.|..|.|
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----SSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQLRLR
    ...||||| |||.|. |. .||||     ...|... .|....| ..| . ... ....|  .. .. .|
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr

0051429 (Phosphotyrosine protein) phosphatases II 212-355 2.2e-22 75.4 In-house 15-223 (272) alignment
Range on Protein: 212-355
Range on HMM: 15-223/272.0
NeaPVEIIPGLLFLGNAT---HSCDSEALKKYNIKYVLNVTPDL----PNKFKESGDIKYLQIPITDHYSQDLAIHF-----------------------
.    ...||.|.....       | ..||...||........      . ...  .|.||..|| |.. ..  ...                       
y..grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltl

-------------------------PDAIQFIEEARSaSSVVLVHCLAGVSRSVTVTLAYLMHtRGLS--------------LNDAFAMVRDRKPDVSPN
                            ....|. .. .  ||||| ||..|. || ...|.  .|.|              | .| ...|.. | . ..
llsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqt

FHFMQQLLSFESQ
 .....|. .. .
eeqylflyealle

subfamily_STYX_pd Subfamily STYX 216-354 6.1e-21 68.2 In-house 13-155 (166) alignment
Range on Protein: 216-354
Range on HMM: 13-155/166.0
VEIIPGLlFLGNAT--HSCDSEALKKYNIKYVLNVTPDLPNKFKE---SGDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSV
 ||.||| |||  .       | |||  | ... .  ..  ..       ...|| . ..|   ...  ..|   .||... .    ||||  ||.||| 
qeilpgl.flgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

TVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFES
.. .||.| | ||   .|||.|..|.  ..||  |..||  .|.
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyea

0036941 (Phosphotyrosine protein) phosphatases II 219-356 7.7e-20 66.8 In-house 22-276 (297) alignment
Range on Protein: 219-356
Range on HMM: 22-276/297.0
IPGLLFLGNATHSCDSEALK----------------------------------------------------------KYNIKYVLNVTPDLPNKFK---
.. ||.||. ....  | |.                                                          ..|.. ....|.. .. ..   
llpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

-----------E---------------SGDIKYLQIPITD----------------HYSQDLAIHFPDAIQFIEEARS------ASSVVLVHCLAGVSRS
           .               ..|... .. .||                    ..  .. . ..|||..|.       ...||||| |||.||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

VTVTLAYLM--------HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
 |. .|.||        ...|... .|. ..|...| . ... ....|  .. .|
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel

subfamily_MSG5_pd Subfamily MSG5 209-356 3.3e-18 59.3 In-house 20-160 (165) alignment
Range on Protein: 209-356
Range on HMM: 20-160/165.0
HNYNEAPVEIIPGLLFLGNATHscdSEALKKYNIkyVLNVTPDLPNKFKESGDIKYLQIPITdHYSQdLAIHFPDAIQFIEEARSASSVVLVHCLAGVSR
. | . |. ..|  |.|    .    . |  ...  |.||. ....       .||  |  . | |. ..  ..   . |  |.|    .||||  |.||
rvyldgpllvlpeklylysepk...lkellsfdl..vinvakeindlellvpavkyyhiewe.hdsk.ivkdlsrltriihaatskrkkilvhcqcglsr

SVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSFESQL
| .. .||.|.  .|||.||. ... .  |.||.. .. ||. .|  |
saslivayimkyynlslrdaydklksvaddispsiglifqlmeweval

subfamily_PTPMT1_pd Subfamily PTPMT1 240-356 8.4e-18 59.4 In-house 53-168 (171) alignment
Range on Protein: 240-356
Range on HMM: 53-168/171.0
YNIKYVLNVTPDLPNKFKESgDIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDV
.|  | |..  .  ...|.  ....||....|.  .    .  ....|||. .|  . | ||| || .|| |.  .|||... ||...|  ....... .
lneeyelkalansteewkkl.gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkii

SPNFHFMQQLLSFESQL
  . . ...|  .|..|
rlakkqwkalqeyeekl

0043336 (Phosphotyrosine protein) phosphatases II 237-352 1.2e-17 59.8 In-house 108-272 (278) alignment
Range on Protein: 237-352
Range on HMM: 108-272/278.0
LKKYNIKYVLNVTPDLPN---------------------------------------------KFKESGDIKYLQIPitDHYSQDLAIHFPDAIQFIEEA
....... ....|..  .                                             . ..   . || .|  ||   .   .. | .... ||
vwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrea

RS-ASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLNDAFAMVRDRKPDVSPNFHFMQQLLSF
..  ...||||| |||.|. |. ..||.     ...|..| .|....| ..|   ... ....|  .
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea

0047943 (Phosphotyrosine protein) phosphatases II 234-349 1.5e-15 52.8 In-house 143-264 (273) alignment
Range on Protein: 234-349
Range on HMM: 143-264/273.0
SEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPitDHYSQDLAIHFPDAIQFIEEARS---ASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSL
||  |.. ....| .|.   .. ..   . |. .|  ||   .   .. . |.....|..    ...|.||| |||.|. |. ...|.     ...|...
seetkddytvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdv

NDAFAMVRDRKPDVSPNFHFMQQL
 .|....|...| . ... ....|
leavkllrsqRpgmvqtpeqyrfl

0051299 (Phosphotyrosine protein) phosphatases II 224-344 2e-14 49.2 In-house 145-273 (288) alignment
Range on Protein: 224-344
Range on HMM: 145-273/288.0
FLGNATHSCDSEALKKYNIKYVLNVTPD----LPNKFKESGDIKYLQIPitDHYSQDLAIHFPDAIQFIEEAR-SASSVVLVHCLAGVSRSVTVTLAYLM
 .|. |  . ||  ... ....| ||.      ... ..   . |...|  ||   | . .. | .... .|. | ...|.||| |||.|. |. ...|.
tygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdll

-----HTRGLSLNDAFAMVRDRKPDVSPNFH
     ...|... .|....| ..| . ... 
leqlekeggvdvleavkrlreqRpgmvqtpe

0046845 (Phosphotyrosine protein) phosphatases II 226-343 3.6e-14 48.3 In-house 133-260 (284) alignment
Range on Protein: 226-343
Range on HMM: 133-260/284.0
GNATHSCDSEALKKYNIKYVLNVTPDL-PNKFKESGDIKYLQIPitDHYSQDLAIHFPDAIQFIEEARSA---SSVVLVHCLAGVSRSVTVTLAYLMHTR
|. |  . ||  |.. ....| .|.   ... ..   . |...|  ||   . . .. . .....|....   .....||| |||.|. |. ...|....
gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleq

--------GLSLNDAFAMVRDRKPDVSPNF
        |... .|....|...|    ..
lekeglllgvdvleavkrlreqRpgmvqtl

0050432 (Phosphotyrosine protein) phosphatases II 232-343 7.8e-13 43.9 In-house 172-285 (308) alignment
Range on Protein: 232-343
Range on HMM: 172-285/308.0
CDSEALKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPitDHYSQDLAIHFPDAIQFIEEARsASSVVLVHCLAGVSRSVTVTLAYLM-----HTRGLSLN
. ||  ... ....| .|.   .. ..   . |.  |  ||   . . .. | ...... .  .....||| |||.|. |. ...|.     ...|... 
llseevlddytvrtleltnlgdgesrtvthfhytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvf

DAFAMVRDRKPDVSPNF
.|....| ..| . ...
eavkklReqRpgmvqtp

subfamily_DSP23_pd Subfamily DSP23 237-338 4e-11 37.8 In-house 27-127 (148) alignment
Range on Protein: 237-338
Range on HMM: 27-127/148.0
LKKYNIKYVLNVTPDLPNKFKESGDIKYLQIPITDHYSQDLAiHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRK
|    ..|.. .| . . . . . .. . .. | |..   |     . .. .||| . .  | |||| |  |. |.   ||.. |.|.  .| | || ..
lldlgvrylvslteegrphveatpnltlvrlriddyhppale.qvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr

PD
| 
pg

Rhodanese Rhodanese-like domain 11-68 7.5e-11 34.5 Pfam-A 2-56 (113) alignment
Range on Protein: 11-68
Range on HMM: 2-56/113.0
KEWLQSQLrslDSKDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRRLAVGKIDLAST
 ..|...|   ......|||.|  .||...||.||||.. .|.  || .  | .||. 
akelkell...ekekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaee

subfamily_Laforin_pd Subfamily Laforin 244-337 1e-07 25.0 In-house 60-152 (183) alignment
Range on Protein: 244-337
Range on HMM: 60-152/183.0
YVLNVtPDLPNK-FKESGdIKYLQIPITDHYSQDLAIHFPDAIQFIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKP
|  |. |.   | .|| | . |. .|. |  ..     .|.|. ..        .| ||| ||| || ..   .|..  | ||.    ..  ..|
ynenl.pitlkklykeeg.layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrp

0048567 (Phosphotyrosine protein) phosphatases II 284-343 3.2e-07 24.9 In-house 63-125 (157) alignment
Range on Protein: 284-343
Range on HMM: 63-125/157.0
AIQFIEEARSASSVVLVHCLAGV---SRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDVSPNF
. .|..  . |. .. ||| ||    .|..|.  .||.   |.. ..|.|..|   |.  |  
lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfr

subfamily_PTPDC1_pd Subfamily PTPDC1 261-339 4.1e-07 24.6 In-house 82-158 (182) alignment
Range on Protein: 261-339
Range on HMM: 82-158/182.0
DIKYLQIPITDHYSQDLAiHFPDAIQFIEEARSASsVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVRDRKPDV
.| . .....|. .. |  .  | .. .. | .    | ||| ||  |   .  .||.... |. ..|  .||...|. 
giyvynfgwkDygvasle.riLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpks

subfamily_RNGTT_pd Subfamily RNGTT 237-350 7.9e-07 22.9 In-house 50-168 (189) alignment
Range on Protein: 237-350
Range on HMM: 50-168/189.0
LKKYNIKYVLNVTPDLPNKFKESG---DIKYLQIPITDHYSQDLAIHFPDAIQFIEE--ARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAM
..|... .|...| . .   ||     .||| .. .. .  .  | .    |. .||  ......|. |||  |  |.  .  .||....  |...| |.
tlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaaval

VRDRKPDVSPNFHFMQQLL
 .  .|    . .....||
FakaRppGiykedylkell

PTPc_DSPc_SM00012 283-321 9.6e-07 24.3 In-house 24-65 (105) alignment
Range on Protein: 283-321
Range on HMM: 24-65/105.0
DAIQFIEEARSA---SSVVLVHCLAGVSRSVTVTLAYLMHTR
.... ... ...   |. |.||| |||.|. |........ .
ellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq

PTPlike_phytase Inositol hexakisphosphate 254-318 9.8e-07 23.5 Pfam-A 85-147 (149) alignment
Range on Protein: 254-318
Range on HMM: 85-147/149.0
NKFKESGDIKYLQIPITDHYSQDlAIHFPDAIQFIEEArSASSVVLVHCLAGVSRSVTVTLAYLM
....|. ..||  |||||... . . .. . ...|... . .. ....| ||  |. |..  . .
eelaegfgvkYvRipitdeqape.eedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL

PTPlike_phytase Inositol hexakisphosphate 254-318 9.8e-07 23.5 In-house 85-147 (149) alignment
Range on Protein: 254-318
Range on HMM: 85-147/149.0
NKFKESGDIKYLQIPITDHYSQDlAIHFPDAIQFIEEArSASSVVLVHCLAGVSRSVTVTLAYLM
....|. ..||  |||||... . . .. . ...|... . .. ....| ||  |. |..  . .
eelaegfgvkYvRipitdeqape.eedvDafvrliksl.prdtalvfnCqaGrgRTTtamviadL

subfamily_PTEN_pd Subfamily PTEN 262-326 1.1e-06 23.8 In-house 80-145 (184) alignment
Range on Protein: 262-326
Range on HMM: 80-145/184.0
IKYLQIPITDHYSQDLAIHFpDAIQFIEE--ARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLN
 .  ..|..|| .  | .   .... ||.  ... . || ||| ||  |. ... |||.... |. .
grvavypfdDhnppplelle.eivediekwleedkknvvvvHCkaGkGRtGvlivayllksllleka

subfamily_CDC25_pd Subfamily CDC25 24-57 7.2e-06 17.2 In-house 11-44 (114) alignment
Range on Protein: 24-57
Range on HMM: 11-44/114.0
KDLILLDCRGSHEYSESHIRGAVNLCIPSIVLRR
......||| ..||.  ||.|||||   . |...
aevliiDcRypyEyegGHikgavnlysreeveee

subfamily_PRL_pd Subfamily PRL 236-338 7.7e-06 20.0 In-house 29-132 (151) alignment
Range on Protein: 236-338
Range on HMM: 29-132/151.0
ALKKYNIKYVLNVT-PDLPNKFKESGDIKYLQIPITDHYSQDLAIhFPDAIQFIEE--ARSASSVVLVHCLAGVSRS-VTVTLAYLmhTRGLSLNDAFAM
 |||...| |  |  |   ..  |. .|. |...  |  .   ..   . .. ..|  .....|.| |||.||. |. | |.|| .    |.. .||  .
elkkeevktvvrvceptydteklekegievldlafddGavPpeev.veeWlellkekfkeepkstvavhcvaGlGraPvlvalali..eaGmkyedavef

VRDRKPD
.|... .
irekrrg

subfamily_DSP11_pd Subfamily DSP11 261-333 8.3e-06 19.8 In-house 79-154 (178) alignment
Range on Protein: 261-333
Range on HMM: 79-154/178.0
DIKYLQIPITDH--YSQDLAIHFPDAIQ-FIEEARSASSVVLVHCLAGVSRSVTVTLAYLMHTRGLSLNDAFAMVR
..|||.. .. |   ...|. .| .|.. |.|.     ... |||  || |.  .   ||... |.. .||  .  
gvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafe