Gene Plip in Drosophila melanogaster

Synonym: 150466_at, CG10371, Dmel\CG10371, PLIP, plip, Dmel_CG10371, Plip

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPMT1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP024_AA protein Get Run
DmelP024_AA_29-194 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPMT1_pd Subfamily PTPMT1 13-196 9.4e-80 261.0 In-house 1-169 (171) alignment 
Range on Protein: 13-196
Range on HMM: 1-169/171.0
FYPTLLYNVLMEKASARNWYDRIDEHVILGALPFRSQANDLIEKENMKAVVSMNEDYELTAFSNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFI
||||||||||.||||.||||||||..||||||||||....||||||.|||||.||.|||.|..|.||.|.|||.|.|||||.|..|.|..|||..|||||
fyPtllynvlvekaskrnwydriDdtvilGalPfrslikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefi

NKFLPLKQRIgglsssyqpenvgsvYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFYTNNV
.|.  ...|.               ||||||||.||||||.||||.|. ..|..|.....|.|..|.|..|||.||. ......
ekvaskgkrv...............YvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeekll
0044763 (Phosphotyrosine protein) phosphatases II 13-193 2.9e-36 120.1 In-house 4-168 (178) alignment 
Range on Protein: 13-193
Range on HMM: 4-168/178.0
FYPTLLYNVLMEKASARNWYDRIDEHVILGALPFrSQANDLIEKENMKAVVSMNEDYELTAFSNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFI
... ||.|. .. .|  .....|.....||.||  ..  .|. ... ...|...|..||  .... . ... ||..|.. . |  . .  | ... ||||
rtrvllsnleglersdyinaseilpglylgslpp.addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefi

NKFLplkqrigglsssyQPENvGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPhILLHTKQWDALRLFYT
...|             .... | |.|||.||. ||.||| .|||.|.|.....|....|..|| |  .  |.  |..|. 
eeal.............dekg.gpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefel
0038934 (Phosphotyrosine protein) phosphatases II 31-194 1.1e-32 108.6 In-house 12-175 (194) alignment 
Range on Protein: 31-194
Range on HMM: 12-175/194.0
WYDRIDEHVILGALPFRSQANDLIEKENMKAVVSMN-------------EDYELTAFSNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFLP
. |.| ...|  ..|  .  .. || ... .. .                |.  | .  ..|.. |.|||.|.| . | ...|..| |.| ......|| 
vgdiitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefln

LKQRigglsssyqpenvGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFYTN
 ..              | |.||||||. |..|||..||....|.....|....| .||... . ....||. .| .
edpg.............gvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryke
0046846 (Phosphotyrosine protein) phosphatases II 27-193 2.4e-31 104.2 In-house 7-170 (176) alignment 
Range on Protein: 27-193
Range on HMM: 7-170/176.0
SARNWYDRIDEHVILGALPFRSQAN---------DLIEKENMKAVVSMNEDYELTAF--SNNTEKWRKLGIEFLQLATTDIFESPNqEKLFRGVEFINKF
  ....|.|....|||..|   |..         ... ... .|||...|..||  .   |  . ..||||..|.| . |    .  | |.. .|||...
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirea

LplkqrigglsssyqPENvGSVYVHCKAGRTRSATLVGCYLMMK-NGWTPDQAVDHMRKCRP-HILLHTKQWDALRLFYT
|               |. | |.|||.||. |..||| .||... .|.....|....|..|| ... . .|.  |. |. 
l..............keg.gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
0045098 (Phosphotyrosine protein) phosphatases II 7-192 5.2e-30 100.2 In-house 14-268 (278) alignment 
Range on Protein: 7-192
Range on HMM: 14-268/278.0
MFARVSFYPTLLYNVLMEKASARNWYDRI--------------------DEHVILGALPFRSQANDL---IEKENMKAVVSMNEDYEL------------
 | .. ..|   .. |...  ..|.|  |                    . . |. . |. | ..|    . ... ...|...| .||            
efllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeg

----------------------------TAFSNNTEKWRKLGIEFLQLATTDIFESPNQE---KLFRGVEFINKFLPLKQRIGGLSSSYQPENvGSVYVH
                            | .... | . ..|.. |.. . . ...|...    ... .|||...| | ..  ..| ...... | |.||
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg.gpvlVH

CKAGRTRSATLVGCYLMMKN---GWTPDQAVDHMRKCRPH-ILLHTKQWDALRLFY
|.||  |..|||..|||...   |.....||...|..||. .. .  |.  |  | 
CsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefl
0048179 (Phosphotyrosine protein) phosphatases II 30-192 4.8e-29 96.3 In-house 2-141 (144) alignment 
Range on Protein: 30-192
Range on HMM: 2-141/144.0
NWYDRIDEHVILGALPFRSQaNDLIEKENMKAVVSMNEDYELTAFSNNtekwrklGIEFLQLATTDIFESPNQEKLFRGVEFINKFlplkqrigglsssy
.....|.... || ||. ..  .|. | . ..|....|.|| . . ..       ||..|.| . |    .  | | . .|||...              
snpseilpglylgslptald.lellkklgittvinlteeyepeflere.......giqylhlpwpDhgvpdllellleflefieea..............

QPENvGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFY
..|. | |.|||.||. |..||| .|||.|.|.....|....|..||..  .  |.  |....
leeg.gpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleye
0048076 (Phosphotyrosine protein) phosphatases II 30-193 6.7e-29 95.8 In-house 2-140 (145) alignment 
Range on Protein: 30-193
Range on HMM: 2-140/145.0
NWYDRIDEHVILGALPFRSQaNDLIEKENMKAVVSMnedyeltafSNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFLPLkqrigglsssy
.|...|.... || ||  ..  .|... . ..|...         ....| . .|||..|.| . |  . .  | | . .|||...|.            
ywpseilpglylgslptald.lellkdlgittvlnl.........tselellerlgiqylylpwpDhgvpdllellleflefieealke...........

qpeNvGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFYT
   . | |.|||.||. |..|||..|||...|.....|....|..||..  .  |.  |..|..
...g.gpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefel
PTEN_1 14-192 5.8e-28 93.0 In-house 15-188 (196) alignment 
Range on Protein: 14-192
Range on HMM: 15-188/196.0
YPTLLYNVL--------MEKASARNWYDRIDEHVILGALPFRSQANDLIEKENMKAVVSMNEDYELTAFSNNTEKWRKLGIEFLQLATTDiFESPNQEKL
.||.|...         | ||..|. ...|||....| |.. ..  |  ....  .||...|..|| ..| . |...| |.|.|..  .| .  |. ..|
lptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieD.hgapslsel

FRGVEFINKFLPLKQRigglsssyqpenVGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFY
|. .. .   | ....             . |.||||||..||.|.| .||| |...|.|.|....|..||.. ... .. .|. ..
fdicksfiewllsdpn............gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyf
0036282 (Phosphotyrosine protein) phosphatases II 34-191 1.5e-26 88.5 In-house 14-165 (174) alignment 
Range on Protein: 34-191
Range on HMM: 14-165/174.0
RIDEHVILGALPFRsqANDLIEKENMKAVVSMNEDYELT------AFSNNTEKWRKLGIEFLQLATTDIFESPNQEkLFRGVEFINKFLplkqrigglss
.| ...|.|. |..    ... ... ..||...| .||        .. . | ...|||..|.| . |  . . .. |.. |.|....|           
yitprliagqgpla..fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveeal...........

syQPENVGSVYVHCKAGRTRSATLVGCYLMMKNGW-TPDQAVDHMRKCR---PHILLHTKQWDALRLF
  .  . | |.|||.||. |..|||..|||..... ....|.|..|..|   |..  .  |.  |. |
..sedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
0041856 (Phosphotyrosine protein) phosphatases II 28-192 3.8e-26 87.2 In-house 17-167 (182) alignment 
Range on Protein: 28-192
Range on HMM: 17-167/182.0
ArnWYDRIDEHVILGALPFR-------------SQANDLIEKENMKAVVSMNedyeltAFSNNTEKWRKLGIEFLQLATTDIFESPnqekLFRGVEFINK
   ..|.| ....||.||..              .  ... ... ...|...       .  . |.. .|||..|.|   |    .    |   ..||..
r..dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd....ldelldfiee

FLPlkqrigglsssyqpeNVGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFY
 |                . | |.|||.||. |..|||..|||.|.|.....||...|..||..  .  |.  |.|..
vle...............eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlal
0048567 (Phosphotyrosine protein) phosphatases II 60-192 4.8e-26 85.9 In-house 2-135 (157) alignment 
Range on Protein: 60-192
Range on HMM: 2-135/157.0
KAVVSMNEDYELTAFSNNTEKWRKLGIEFLQLATTD--IFESPNQE----KLFRGVEFINKFLPLKQRIGGLSssyqpenvGSVYVHCKAGR---TRSAT
|......|... . . ..   ..|   ..|.. ..|  ..|.. ..    .| . ..||.|. .. . .   .        . ..||||||.   .|.||
kengdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelag........kaiavhckaglkkrgrtat

LVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFY
|.||||....|.||..|....| .||..... ... .|.|..
LigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn
0051082 (Phosphotyrosine protein) phosphatases II 31-185 1.3e-25 85.2 In-house 7-142 (151) alignment 
Range on Protein: 31-185
Range on HMM: 7-142/151.0
WYDRIDEHVILGALPfRSQANDLIEKENMKAVVSMNEDYELTafsNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFLPlkqrigglsssyq
.. .......... |  ..  .|..... |..|......|     ...| ...||||.|..  .|  . . .. .   .||....|              
nfsyvtgglyrsggp.ladflellkelgiktivnlrseeerg...ycpeylpelgievlhipildwpdpglplsfdavleflellld.............

pENVGSVYVHCKAGRTRSATLVGCYLMMkNGWTPDQAVDHMRKCRPHILLHTKQW
  . | |.|||.||. |..|||..|||.  |.....|....|..||..  .  |.
.kkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqf
0042113 (Phosphotyrosine protein) phosphatases II 29-191 4.9e-25 83.8 In-house 12-238 (245) alignment 
Range on Protein: 29-191
Range on HMM: 12-238/245.0
RNWY--------------------------------DRIDEHVILGALPFRSQAND---LIEKENMKAVVSMNEDYELTA--------------------
.|.|                                .|| ...|... | ..  .|   .. ... ...|...|. ||                      
knrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftv

-----------------FSNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFLPLkqrigglsssyqPENvGSVYVHCKAGRTRSATLVGCYL
                  .|. ... . .| ...|   |  . .. | |.. .||..|.|              ..| | |.|||.||. |..|....||
tllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae............dsn.gpvlVHCsaGvgRtGtfiaayl

M-----MKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLF
|        |.....||...|..||..     |.  |. .
mleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0037934 (Phosphotyrosine protein) phosphatases II 32-192 2.5e-24 81.6 In-house 39-238 (243) alignment 
Range on Protein: 32-192
Range on HMM: 39-238/243.0
YDRIDEHVILGALPFRSQAND-------LIEKENMKAVVSMNEDYELTAF------------------------------------SNNTEKWRKLGIEF
. .. ...|.. .|  .  .|       .. ... ...|...|..||...                                      ..... .|.| .
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

LQLATTDIFESPNQEKLFRGVEFINKFLPLKQrigglsSSYQPE-NvGSVYVHCKAGRTRSATLVGCYLMMKN-GWTPDQAVDHMRKCRPH-ILLHTKQW
..|.  |    .. | | . ......|.          | ..   . | |.|||.||. |..||. .|||... |.....||...|..||. .     |.
hylpwpdhgvPdspedlldfldevrefieell......sllaldsg.gpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy

DALRLFY
  |. ..
rflyeal
0049772 (Phosphotyrosine protein) phosphatases II 60-190 5.2e-24 81.0 In-house 167-268 (314) alignment 
Range on Protein: 60-190
Range on HMM: 167-268/314.0
KavvsmnedyeltAFSNNTEKWRKLGIEFLQLATTDiFESPNQEKLFRGVEFINKFlPlkqrigglsssyqpeNVGSVYVHCKAGRTRSAT-LVGCYLMM
|               .. |.. .|||..|.. ..| .. |  | . . .|||... .               . | |.||||||. |..| .| .|||.
k............eelydpelferlgikylripvpD.gsaplledfdeflefieea.d...............kggpvlvHCkaGkgRtgtfvvaaylmk

KNGWTPDQAVDHMRKCRPhILLHTKQWDALRL
..|.....|....|..|| |  .  ..  |..
llgvsleealedvrlkRp.inpnpgfieqleq
0049260 (Phosphotyrosine protein) phosphatases II 53-191 3.5e-22 74.2 In-house 28-145 (152) alignment 
Range on Protein: 53-191
Range on HMM: 28-145/152.0
LIEKENMKAVVSMNEDYEltafsnNTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFLPLKQRigglsssyqpenvgSVYVHCKAGRTRSATLV
.. . . ...|...|..|      ... . . .|..|.| . |    .. . |   ..||.|..  |.                |.|||.||  |..|||
mlkelgittivmltelle......lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkgg..............pvlVHCsaGvgRtgtlv

GCYLMMkNGWTPDQAVDHMRKCRPHILLHTKQWDALRLF
 .|||. .|.....||...|..||..  .  |.  |  |
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyef
0043147 (Phosphotyrosine protein) phosphatases II 39-191 4.1e-22 74.1 In-house 22-156 (172) alignment 
Range on Protein: 39-191
Range on HMM: 22-156/172.0
VILGALPFRSQAN---DLIEKENMKAVVSMNEDyeltafSNNTEKWRKLGIEFLQLATTDIFESpNQEKLFRGVEFINKFLPLKQrigglsssyqpenVG
.| .  |.|.  .   ... ... ...|...|        ...|.  .|||..| |   |     . | | . .|||...| |..              |
fiatqgplrntladfwrmlkelgithivnltel......lydpellerlgiqylylpwpDhgvp.llellleflefidellalsp.............gg

SVYVHCKAGRTRSATLVGCYLMMkNGWTPDQAVDHMRKCRPHILLHTKQWDALRLF
 |.|||.||  |..||| .|||.  |.....||...|..||..  .  |.  |. |
pvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyf
0039614 (Phosphotyrosine protein) phosphatases II 28-191 8.9e-22 73.3 In-house 92-284 (297) alignment 
Range on Protein: 28-191
Range on HMM: 92-284/297.0
ARNWYDRIDEHVILGALPFRSQAN---DLIEKENMKAVVSMNEDYELT-----AFSNNTEKWRKLGIEFLQLATTDIFE---------------------
  . ||... ..|.   |  .  .    .. ... ...|....  ||       ........ .. ...|.  . | .                      
yvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqyt

------SP-NQEKLFRGVEFINKFLPLKqrigglsssyqpENVGSVYVHCKAGRTRSATLVGCYLM-----MKNGWTPDQAVDHMRKCRPHILLHTKQWD
       | . | |.. .|.....|               .. | |.|||.||  |..|....|||      . |.....||...|..||..     |. 
gwpdhgvppslellleflelvrealael............pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyr

ALRLF
 |. .
flyda
PTPc_motif_SM00404 34-192 8.7e-21 69.3 In-house 4-138 (140) alignment 
Range on Protein: 34-192
Range on HMM: 4-138/140.0
RIDEHVILGALPFRSqANDLIEKENMKAVVSMNEDYELTafsnntekWRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFlplkqrigglsssyqPEN
|| .|..|| ..  .   .|..| ....|... |  .||          . |...||.   |  ... ...| . ..||...                ..
rilphlylgskskaq.npallkklgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfiena...............ekk

VGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFY
 |.|.|||.|| .|||||. .|||...... ..|.. ... ||.|   .. .  |  ..
ggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieye
0040438 (Phosphotyrosine protein) phosphatases II 35-191 4.7e-20 67.5 In-house 84-271 (317) alignment 
Range on Protein: 35-191
Range on HMM: 84-271/317.0
IDEHVILGALPFRSQAND---LIEKENMKAVVSMNEDYELTAFS------------------NNTEKWRKLGIEFLQLATTDI-----------------
.  . |.   |  .  .|   .. ... . .|...|  ||                      ....   . ||. ..|  .|                  
lkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWp

-FESP-NQEKLFRGVEFINKFLplkqrigglsssyQpENVGSVYVHCKAGRTRSATLVGCYLM-----MKNGWTPDQAVDHMRKCRPHILLHTKQWDALR
 .  | . . |.. .|.....|             . .. | | |||.||  |..|....|||      ..|.....||...|..||..     |.  | 
dhgvppspdllldfleavreal.............e.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrfly

LF
 .
da
0043336 (Phosphotyrosine protein) phosphatases II 31-189 1.8e-19 65.7 In-house 50-270 (278) alignment 
Range on Protein: 31-189
Range on HMM: 50-270/278.0
WYD--------------------------------RIDEHVILGALPFRSQANDL---IEKENMKAVVSMNEDYELTA----------------------
.|                                 .. ...|.   |  .  .|    . ... . .|...|. ||                        
rykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtll

--------------FSNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFLplkqrigglsssyqPENVGSVYVHCKAGRTRSATLVGCYLM--
               .|. ... . .  .  |.  |    .. . |.. .......|              . . | |.|||.||  |..|....||.  
keehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal..............edsngpvlVHCsaGvgRTGtfialyllle

---MKNGWTPDQAVDHMRKCRPHILLHTKQWDALR
      |.....||...|..||...    |.  |.
qlekeggvdleeavkelreqRpgavqtpsqyrfly
0040439 (Phosphotyrosine protein) phosphatases II 34-191 1.9e-19 65.7 In-house 51-241 (249) alignment 
Range on Protein: 34-191
Range on HMM: 51-241/249.0
RIDEHVILGALPFRSQAND---LIEKENMKAVVSMNEDYELTAFS---------------------------------------NNTEKWRKLGIEFLQL
.|  ..|.   |  .  .|   .. ... ...|..... ||                                            . |. . |.| .. .
yikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdw

ATTDIFesPNQEKLFRGVEFINKFLPLKqrigglsssyqpENVGSVYVHCKAGRTRSATLVGCYLM-----MKNGWTPDQAVDHMRKCRPHILLHTKQWD
  ...   |. | |.. .| ..|.|               .. | |.|||.||  |..|....|||      ..|.....||...|..||..     |. 
pdhgvp..psfedlldfieavrkaleel............pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr

ALRLF
 |  .
flyea
0045450 (Phosphotyrosine protein) phosphatases II 36-191 1.4e-18 63.1 In-house 106-299 (307) alignment 
Range on Protein: 36-191
Range on HMM: 106-299/307.0
DEHVILGALPFRSQAND---LIEKENMKAVVSMNEDYELTAF------S-------------NNTEKWRKLGIEFLQLATT-------------------
. . |.   |  .  .|   .. ... ...|...|. ||.        .             .....  . |.  ..|  |                   
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgw

-DIFESPNQEKLFRGVEFINKFLPLkqrigglsssyQPENvGSVYVHCKAGRTRSATLVGCYLMMKNG--------WTPDQAVDHMRKCRPHILLHTKQW
 |   .|. | |.. .| ..|.|              |.. | |.|||.||  |..|....|||....        .....||...|..||..     |.
pdhgvppsfeelldfieevrkalee...........lpkg.gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

DALRLF
  |. .
rflyea
0047943 (Phosphotyrosine protein) phosphatases II 53-186 2.6e-18 61.9 In-house 96-262 (273) alignment 
Range on Protein: 53-186
Range on HMM: 96-262/273.0
LIEKENMKAVVSMNEDYELTA------FSNNTE----------------------KWRKLGIEF-----------LQLATTDIFESP-NQEKLFRGVEFI
.. ..| . .|...|..||        .... .                      ..|.| ...           ..  .   .  | . | |.. .|..
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

NKFLPL--KQrigglsssyqpenvGSVYVHCKAGRTRSATLVGCYLM-----MKNGWTPDQAVDHMRKCRPHILLHTKQWD
.|.|    ..              | |.|||.||  |..|.. ..|.     ...|.....|| ..|..||..     |. 
rkalealpsn..............gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr
0036941 (Phosphotyrosine protein) phosphatases II 41-191 3.8e-18 61.3 In-house 82-272 (297) alignment 
Range on Protein: 41-191
Range on HMM: 82-272/297.0
LGALPFRSQAND---LIEKENMKAVVSMNEDYELTA------FSNNTEKWRKLGIEFLQLATTDI----------------------------------F
.   |  .  .|   .. ..| . .|...|..||        ........ . |  ...| ....                                  .
atqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdh

ESPN-QEKLFRGVEFINKFLPLKqrigglsssyqPENvGSVYVHCKAGRTRSATLVGCYLM--------MKNGWTPDQAVDHMRKCRPHILLHTKQWDAL
  |.  . |.. .|...|.|.|            |.. | |.|||.||  ||.|.....||        . .|... .|| ..|..||..     |.  |
gvpespaslldfielvrkvlkll...........psg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

RLF
. .
yea
DSPc Dual specificity phosphatase, catalytic domain 63-192 1.4e-17 58.8 Pfam-A 11-131 (133) alignment 
Range on Protein: 63-192
Range on HMM: 11-131/133.0
VSMNEDYELTAFSNNTEK------WRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFlplkqrigglsssyqPENVGSVYVHCKAGRTRSATLVGCYL
 ...|....|.  | |..        |  ||.|..   |  |.  ...| . ||||.|.                .. ..|.|||.|| .|||||. .||
lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka...............eqkgkkvlVHCqaGisRSatliiaYl

MMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFY
|...... ..|...... |..|   ....  |. ..
mktknlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 63-192 1.4e-17 58.8 In-house 11-131 (133) alignment 
Range on Protein: 63-192
Range on HMM: 11-131/133.0
VSMNEDYELTAFSNNTEK------WRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFlplkqrigglsssyqPENVGSVYVHCKAGRTRSATLVGCYL
 ...|....|.  | |..        |  ||.|..   |  |.  ...| . ||||.|.                .. ..|.|||.|| .|||||. .||
lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefieka...............eqkgkkvlVHCqaGisRSatliiaYl

MMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFY
|...... ..|...... |..|   ....  |. ..
mktknlslneAyefvkerrskispnagflrqLleye
0051429 (Phosphotyrosine protein) phosphatases II 53-193 6.3e-16 54.3 In-house 40-222 (272) alignment 
Range on Protein: 53-193
Range on HMM: 40-222/272.0
LIEKENMKAVVSMNEDYELTAFSNNTEKwrkLGIEFLQLATTDIFESPNQ--------------------------------------------------
 ..... |..|.. ...|. ..    .     ||..|.| . |  . .                                                    
rlkelgiktivdLrseeErgrlkcdryw...pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvp

-EKLFRGVEFINKflplkqrigglsssyqpenVGSVYVHCKAGRTRSATLVGCYLMMkNGWT--------------PDQAVDHMRKCRPHILLHTKQWDA
 | | . .|....                    | |.|||.||. |..|.| ..|..  |..              ...||...|..||..  .  |.  
qeallellellld...................ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylf

LRLFYT
|. .. 
lyeall
0050432 (Phosphotyrosine protein) phosphatases II 53-184 1.6e-15 52.7 In-house 127-287 (308) alignment 
Range on Protein: 53-184
Range on HMM: 127-287/308.0
LIEKENMKAVVSMNEDYELTA------FSNNTE---------------------------------KWRKLGIEFLQLATTDIFESPN-QEKLFRGVEFI
.. ..| . .| ... .|         . ....                                 .   . .  ..  .   .  |.  | |.. .|..
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

NKFLplkqriGGlsssyqpenvGSVYVHCKAGRTRSATLVGCYLM-----MKNGWTPDQAVDHMRKCRPHILLHTKQ
.|.|      .|          | ..|||.||  |..|.. ..|.     ...|... .|| ..|..||.      |
rksl......pg..........gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq
subfamily_DSP12_pd Subfamily DSP12 33-195 6.5e-15 49.9 In-house 3-143 (155) alignment 
Range on Protein: 33-195
Range on HMM: 3-143/155.0
DRIDEHVILGALPFRSQAnDLIEKENMKAVVSMNEDyELTAFSNNTEKWRKLGIEFLQLATTDIFESpnqekLFRGVEFINKFLplKQrigglsssyqpe
.||.. . || |.   .  .| .. ....|.|. .  ||  ..... | ... |. |   ..||..      | . |.||.. |  ..            
srilpglylggleavqee.ellkelkithvlsvike.elpehklkkgkvstkfiqilDepeediLsh.....ldeavdFieeal..ee............

nVGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLFYTNN
  |.|.|||.||  ||.|.|  ||| |...  ..|.. ... .|.|   .   . |.||.   
.egavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
0046845 (Phosphotyrosine protein) phosphatases II 54-187 1.5e-14 49.5 In-house 97-265 (284) alignment 
Range on Protein: 54-187
Range on HMM: 97-265/284.0
IEKENMKAVVSMNEDYELT------------------------------------AFSNNTEKWRKLGIEFLQ---LATTDIFESPNQEKLFRGVEFINK
. ..| . .|...|  |                                       ..   ... .  ..  .   ..  |    |. | |.. ......
vweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

FLPLkqrigglsssyqPENVGSVYVHCKAGRTRSATLVGCYLMMKN--------GWTPDQAVDHMRKCRPHILLHTKQWDA
.|.              .. | . |||.||  |..|.. ..|...         |... .|| ..|..||.      |   
llen............lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrf
0051299 (Phosphotyrosine protein) phosphatases II 53-184 1.8e-14 49.3 In-house 111-274 (288) alignment 
Range on Protein: 53-184
Range on HMM: 111-274/288.0
LIEKENMKAVVSMNEDYELTA-------------------------FSNN----------------TEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEF
.. ..| . .|.... .||                            ...                 ..  .  . |  ..  |    .. | |.. ...
mvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrl

INKFLPlkqrigglsssyqpENVGSVYVHCKAGRTRSATLVGCYLM-----MKNGWTPDQAVDHMRKCRPHILLHTKQ
..|.|.               . | |.|||.||  |..|.. ..|.      ..|... .|| ..|..||..     |
vrkala..............sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeq
subfamily_DSP19_pd Subfamily DSP19 133-179 5e-12 40.4 In-house 89-134 (152) alignment 
Range on Protein: 133-179
Range on HMM: 89-134/152.0
NvGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHIL
. | |.|||.||. |||..|  ||| |.  .  .|.. .|. || | 
d.gavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcik
subfamily_CDC14_pd Subfamily CDC14 134-183 1.1e-11 39.2 In-house 263-312 (328) alignment 
Range on Protein: 134-183
Range on HMM: 263-312/328.0
VGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTK
 |.. ||||||  |  ||..|||| . . |  .|. ..| |||  ..  .
eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpq
subfamily_DSP3_pd Subfamily DSP3 66-175 2.8e-11 37.3 In-house 44-138 (162) alignment 
Range on Protein: 66-175
Range on HMM: 44-138/162.0
NEDyELTAFSNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFLPLkqrigglsssyqpeNVGSVYVHCKAGRTRSATLVGCYLMMKNGWTPD
 |  ...    ..| ...|.|..| |  .| .|.  ..   . ..||.. |                . | |.|||..|  ||||||  |||...  |  
aeg.rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsq..............kegkvlvhcvvGvsRsatlvlayLmirrkmtlv

QAVDHMRKCR
.|. ..|| |
eairtvrkkR
subfamily_PTPDC1_pd Subfamily PTPDC1 135-191 3.8e-11 37.8 In-house 115-171 (182) alignment 
Range on Protein: 135-191
Range on HMM: 115-171/182.0
GSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALRLF
| | ||| ||. |   |. |||. ..  |...|.. .|. ||. .   .| . .. |
gkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkef
subfamily_LRR-DSP_pd Subfamily LRR-DSP 134-186 5.3e-11 36.1 In-house 197-249 (263) alignment 
Range on Protein: 134-186
Range on HMM: 197-249/263.0
VGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWD
 | | |||.|| .||.||| .|||.|.  .  .|.| . | ||.|   .   |
kGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkd
subfamily_DSP1_pd Subfamily DSP1 133-178 4.4e-10 33.9 In-house 94-139 (163) alignment 
Range on Protein: 133-178
Range on HMM: 94-139/163.0
NVGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHI
. | |..||.||  ||.||.  |||... .. ..| | ... |. |
knGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsii
subfamily_DSP14_pd Subfamily DSP14 133-189 5.6e-10 33.4 In-house 82-138 (157) alignment 
Range on Protein: 133-189
Range on HMM: 82-138/157.0
NVGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALR
. | . |||.||. |||.|.  |||  .  .  .|  .....|| |   .  |  |.
kggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqli
subfamily_RNGTT_pd Subfamily RNGTT 77-188 6.2e-09 29.8 In-house 69-167 (189) alignment 
Range on Protein: 77-188
Range on HMM: 69-167/189.0
NTEKWRKLGIEFLQLATTDIFESPNQEKLFRGVEFINKFLPlkqrigglsssYQPENVgsVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRP
..|.  | ||.. .|...   |.|..|.  .  . ...|              .||.|  . |||. |  |.  |. .||. |. |  ..||.  .|.||
dkeelekegikyvklqcagkgeaPeaeqvkefiklveeffk...........knpeev..igvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp

HILLHTKQWDAL
  . . .  . |
pGiykedylkel
subfamily_DSP10_pd Subfamily DSP10 135-178 6.6e-09 29.8 In-house 93-136 (159) alignment 
Range on Protein: 135-178
Range on HMM: 93-136/159.0
GSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHI
 .| |||.||  ||||.|  ||| . . .  .| ......|| |
srvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpii
subfamily_Slingshot_pd Subfamily Slingshot 135-178 1.1e-08 28.7 In-house 97-140 (169) alignment 
Range on Protein: 135-178
Range on HMM: 97-140/169.0
GSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHI
 .| |||| | .|||. |  | | . |.. ..|...... |  |
skvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvi
subfamily_DSP15_pd Subfamily DSP15 134-176 1.6e-08 28.8 In-house 78-120 (151) alignment 
Range on Protein: 134-176
Range on HMM: 78-120/151.0
VGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRP
 ..|.||| ||  ||.|||  |||        .|.. ....| 
eenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRs
subfamily_DSP23_pd Subfamily DSP23 135-189 3.4e-08 28.3 In-house 85-139 (148) alignment 
Range on Protein: 135-189
Range on HMM: 85-139/148.0
GSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHILLHTKQWDALR
 .| |||  || |. |.. |||. ... .  .|.  .|. ||  .   .| ...|
eavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklvr
PTPc_DSPc_SM00012 124-181 3.6e-08 28.9 In-house 38-92 (105) alignment 
Range on Protein: 124-181
Range on HMM: 38-92/105.0
GlsssyqpenVGSVYVHCKAGRTRSATLVGCYLMMKNGWTP------DQAVDHMRKCRPHILLH
           ..| |||.||  |..|.|  ...... ..        | | ..|| ||.    
s.........skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqt
subfamily_STYXL1_pd Subfamily STYXL1 135-179 4.4e-08 26.5 In-house 93-137 (157) alignment 
Range on Protein: 135-179
Range on HMM: 93-137/157.0
GSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHIL
  | |  . | .|||... .||| .. .|  .| ....||.. . 
evvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvk
subfamily_DSP6_pd Subfamily DSP6 135-178 7.1e-08 26.1 In-house 94-137 (158) alignment 
Range on Protein: 135-178
Range on HMM: 94-137/158.0
GSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHI
 .| ||| || .|| |.. .||| |.  . ..| | ..| ...|
skvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksni
subfamily_DSP8_pd Subfamily DSP8 134-178 8.8e-08 25.9 In-house 93-137 (159) alignment 
Range on Protein: 134-178
Range on HMM: 93-137/159.0
VGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHI
 |.| ||. ||. ||||.. .|.| .   . |.|  .... || |
ngrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrpti
DSPn Dual specificity protein phosphatase, N-terminal half 142-178 1e-07 22.7 Pfam-A 78-114 (141) alignment 
Range on Protein: 142-178
Range on HMM: 78-114/141.0
KAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHI
.  |...|.|.|.|........|..|.. ...  |..
ekkranaalLigaYavivlklspeealkplesvepsl
Y_phosphatase Protein-tyrosine phosphatase 58-185 1.8e-07 26.2 Pfam-A 105-226 (235) alignment 
Range on Protein: 58-185
Range on HMM: 105-226/235.0
NMKAVVSMNEDYELTAFSNNTEKWRK--LGIEFLQLATTDIFESPnqEKLFRGVEFINKFLPLKqrigglsssyqPENVGSVYVHCKAGRTRSATLVGCY
... . . ...| |. .. . .|...    .. |.. .    . |  |.    ...|.|.   |            .. |.| |||.||  |..|.|   
lkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk...........eaksgpvvVhCsaGvgRtgtfvald

LMMKNGWT-----PDQAVDHMRKCRPHILLHTKQW
.....  .       |.| ..||.||..    .| 
illeqleaeeevdvlqivkelRkqRpgmvqsleqY
Y_phosphatase Protein-tyrosine phosphatase 58-185 1.8e-07 26.2 In-house 105-226 (235) alignment 
Range on Protein: 58-185
Range on HMM: 105-226/235.0
NMKAVVSMNEDYELTAFSNNTEKWRK--LGIEFLQLATTDIFESPnqEKLFRGVEFINKFLPLKqrigglsssyqPENVGSVYVHCKAGRTRSATLVGCY
... . . ...| |. .. . .|...    .. |.. .    . |  |.    ...|.|.   |            .. |.| |||.||  |..|.|   
lkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk...........eaksgpvvVhCsaGvgRtgtfvald

LMMKNGWT-----PDQAVDHMRKCRPHILLHTKQW
.....  .       |.| ..||.||..    .| 
illeqleaeeevdvlqivkelRkqRpgmvqsleqY
subfamily_MKPLT_pd Subfamily MKPLT 132-175 1.9e-07 24.8 In-house 97-140 (164) alignment 
Range on Protein: 132-175
Range on HMM: 97-140/164.0
ENVGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCR
.. | |.|||  |..||..    .|.  .||| ..| ..... |
dsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerr
subfamily_MKPLV_pd Subfamily MKPLV 132-175 1.9e-07 24.8 In-house 97-140 (164) alignment 
Range on Protein: 132-175
Range on HMM: 97-140/164.0
ENVGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCR
.. | |.|||  |..||..    .|.  .||| ..| ..... |
dsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerr
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 78-179 2e-07 24.5 In-house 48-136 (154) alignment 
Range on Protein: 78-179
Range on HMM: 48-136/154.0
TEKWRKLGIEFLQLattDIFESPNQ---EKLFRGVEFInkflplKQRIGGLSSsyqpenvGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKC
..    . ||.|.|   ..|. .|.   ||| .  |||      .. |||.         . | ||...| .|||.|.  ||| |   .  .|.  ....
sdindgfiieylnl...elfddvnfdiiekldkafefi......ddaiggven.......nkvlvhsdkGvsrsaallisylmdklkislslalellkds

RPHIL
|. | 
ryiik
subfamily_DSP11_pd Subfamily DSP11 77-183 4.8e-07 23.8 In-house 71-165 (178) alignment 
Range on Protein: 77-183
Range on HMM: 71-165/178.0
NTEKWRKLGIEFLQLATTDIfESPNQEKLFRGVEFINKFLplkqrigglssSYQPENVGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRP
..... . |...|.| ..   | |..| . .  |....||            .. .|   . |||  |  |.  |.  ||. ..|. |..|.. . ..| 
kkkeltdegvkylklncpGh.evpkeelvkkfkeavkefl...........eknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearG

HILLHTK
| | . .
hsleren
DSPc_SM00195 66-185 5.7e-07 24.5 In-house 151-251 (263) alignment 
Range on Protein: 66-185
Range on HMM: 151-251/263.0
NE--DYELTAFSNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRgvefinkflplkqrigglsssyqpenVGSVYVHCKAGRTRSATLVGCYLMMKNG--
.|  . . ..   . ..| . |.   .  ....... ...|                              | . |||.||  |..|.|   .....   
kegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..........................sgpivVhCsaGvgRtgtfvtidiilsklee

---WTPDQAVDHMRKCRPHILLHTKQW
      .. | ..|| ||..    .|.
ekkvdifeivkelRkqRpgmvqtleqY
PTPc_SM00194 66-185 5.7e-07 24.5 In-house 151-251 (263) alignment 
Range on Protein: 66-185
Range on HMM: 151-251/263.0
NE--DYELTAFSNNTEKWRKLGIEFLQLATTDIFESPNQEKLFRgvefinkflplkqrigglsssyqpenVGSVYVHCKAGRTRSATLVGCYLMMKNG--
.|  . . ..   . ..| . |.   .  ....... ...|                              | . |||.||  |..|.|   .....   
kegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..........................sgpivVhCsaGvgRtgtfvtidiilsklee

---WTPDQAVDHMRKCRPHILLHTKQW
      .. | ..|| ||..    .|.
ekkvdifeivkelRkqRpgmvqtleqY
subfamily_PRL_pd Subfamily PRL 125-186 1.7e-06 22.2 In-house 81-140 (151) alignment 
Range on Protein: 125-186
Range on HMM: 81-140/151.0
LSSSYQPENVGSVYVHCKAGRTRSATLVGCYLmMKNGWTPDQAVDHMRKCRPHIlLHTKQWD
| .... |.  .| ||| ||  |.  ||   | . .| ....||. .|. |    . .|| .
lkekfkeepkstvavhcvaGlGraPvlvalal.ieaGmkyedavefirekrrga.inskqlk
P53_C Transcription factor P53 - C terminal domain 67-122 2.4e-06 13.8 Pfam-A 15-67 (71) alignment 
Range on Protein: 67-122
Range on HMM: 15-67/71.0
EDYELTAFSNNTEkWRKLGIE-FLQLATTDIFESPNQEKLFRgveFINKFLPLKQRI
 || |.    | | |    || ... |.....  |||| | |     ||.| ||.| 
Gdyrlaitcpnke.wllqsieGmikeaaaevlrnpnqenlrr...hankllslkkra
subfamily_PTEN_pd Subfamily PTEN 136-175 2.8e-06 22.4 In-house 116-156 (184) alignment 
Range on Protein: 136-175
Range on HMM: 116-156/184.0
SVYVHCKAGRTRSATLVGCYLMMKNGWTP-DQAVDHMRKCR
 | ||||||. |. .|. .||. .. ..  ..|...  . |
vvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
subfamily_Laforin_pd Subfamily Laforin 132-179 3.3e-06 20.1 In-house 108-155 (183) alignment 
Range on Protein: 132-179
Range on HMM: 108-155/183.0
ENVGSVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHIL
|.   |||||.||  ||...|  .|.   ||.  .   ..   || . 
ekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvy
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 36-178 5.4e-06 20.0 In-house 12-130 (148) alignment 
Range on Protein: 36-178
Range on HMM: 12-130/148.0
DEHVILGALPFRSQANDLiEKENMKAVVSMNEDYElTAFSNNtekwrklGIEFLQLATTDiFESPNQEKLFrgvEFINKFLPLKQRIGglsssyqpenvG
| .. ||. .. .... | .. .. ..|..... .  |. .        |||.|..|  |  .  .  ..|   | | .|.  ..  |           .
dafLFlGskksaadleal.kalgvtrivnatkerd.naldqr.......gieYlhvaldD.kpkedlsaiF...ediiafvrkakdeG...........r

SVYVHCKAGRTRSATLVGCYLMMKNGWTPDQAVDHMRKCRPHI
 | ||.. |. ||. |.  .|.  .  .  .|.. ..  |...
rvLvhlqmGvsrssalallwlidfkrvslkealalvkskrryv