Gene mRNA-cap in Drosophila melanogaster

Synonym: CG1810, Dmel\CG1810, PIR, Dmel_CG1810, mRNA-cap

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily RNGTT
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP025_AA protein Get Run
DmelP025_AA_23-194 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_RNGTT_pd Subfamily RNGTT 16-205 4.2e-94 307.6 In-house 1-189 (189) alignment 
Range on Protein: 16-205
Range on HMM: 1-189/189.0
PNRWLYCPRKSdTIIAERFLAFKTPLSNNFHDKMPIECTFQPEMLFEYCKTLKVKLGLWVDLTNTKRFYDRSAVEELGAKYIKLQCRGHGETPSPEQTHS
|.|||.||||. ..|||.||.||||||....|....|..|.|.||..|.|||||||||..|||||.|.||....|. |.||.||||.|.||.|..||...
PerWlnCPrkg.kliaekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvke

FIEIVDNFINERPFDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARPPGIYKQDYINELYKRYEDTNAAPAAPEQPNWCLD
||..|..|....| .||.|||||||||||||||.||||. |.||.||.|.||.||||||||.||..||..||.|...|.||||.|.|||.
fiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadveeaiaapelpdwcle
mRNA_cap_enzyme mRNA capping enzyme, catalytic domain 307-497 2.5e-72 231.9 Pfam-A 1-192 (192) alignment 
Range on Protein: 307-497
Range on HMM: 1-192/192.0
QPVSMDRENIKRLSEIPYRVSWKADGTRYMMLIDGRdEVYFFDRNHSCFQVENVTFVESRN--LNEHLDGTLVDGEMVLDKIGETVTPRYLIYDIVRLSN
||||..|||.| |.. .| ||.||||.|...||. . |||..||......|||..|. ...   .....|||.|||.|.|.. |. ..|||||||.....
qpvslsrenlkllkqkdYyvseKaDGlRvlllitkk.evylidrdnevylvenlkfplklekekekvhhgtllDGElvidtveeeqklryliyDilaing

RDVRDEPFYpNRLDYIKTEVIGPRILGM-KHGIINQRLQAFSVRGKDFWDIWMSARLLGEKFSRTLAHEPDGLIFQPSKQPYTAGTCSDVFKWK
. | ..|.. .||...|.|.| ||   . |..||...|..|.|| |.|........|| .|. ..|.|| ||||||....||.||......|||
elvserpls.kRleilkkeiikpraeeklkthiiktelepfkvrlksfilllalekllskkkikklsheiDGLIfqsvdtpYvagrdknllKWK
0038934 (Phosphotyrosine protein) phosphatases II 15-208 4.3e-63 207.7 In-house 2-194 (194) alignment 
Range on Protein: 15-208
Range on HMM: 2-194/194.0
LPNRWLYCPRKSDtIIAERFLAFKTPLSNNFHDKMPIECTFQPEMLFEYCKTLKVKLGLWVDLTNTKRFYDRSAVEELGAKYIKLQCRGHGETPSPEQTH
||.|||...| .| || .||.|||.|||..... .. .. | ||.|..|.|.|.|||||..|||||.|.||.. .|..| .|.||.. ..|..|| |...
lPdrwlkyervgd.iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleill

SFIEIVDNFINERPFDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARPPGIYKQDYINELYKRYEDTNAAPAAPEQPNWCLDYDD
.|...|| |.|| |  |.||||..|..|||.|...||..||..|. .|.|.|...||..|..|||...|.|||.... |. |||.|...|...|
rfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlapekpellleded
subfamily_DSP11_pd Subfamily DSP11 15-189 2.5e-45 148.6 In-house 1-176 (178) alignment 
Range on Protein: 15-189
Range on HMM: 1-176/178.0
LPNRWLYCPRKSDTIIAERFLAFKTPLSNNFHDKMPIECTFQPEMLFEYCKTLKVKLGLWVDLTNTKRFYDRSAVEELGAKYIKLQCRGHGEtPSPEQTH
.|.||       |.|   ||.||||||...|..|.. | .| |. |.|  .  . |||| .|||||.|.|....... | || ||.| ||   |. |  .
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhev.pkeelvk

SFIEIVDNFI--NERPFDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARPPGIYKQDYINELYKRYED
.|.| |..|.  |.    .|.|||||| ||||.||  ||... . . . |.  | .||   . ...|...|.|. .|
kfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkklekd
mRNA_cap_C mRNA capping enzyme, C-terminal domain 500-599 6.8e-35 109.0 Pfam-A 1-105 (105) alignment 
Range on Protein: 500-599
Range on HMM: 1-105/105.0
ELNSVDFRLKIITERGEGLLTKKVGFL-YV-GGHDaPY---GRMQRLTKETRELDNRIVECTMNQ-FGNWDFMRERTDKKNPNSYNTARSVVDSIKHPVT
|||.|||.||. .|...|||....| | || ||.| .     ....|.....||...||||....  |.|.|.|.|.||..|||..||..|..||...||
elntvDfllklekeeedglLeeekgkldyveggsd.efitakekeklksdekelkgkIvEcklddkkgrWkflriRkDKsepNsistaekvlksiednvt

KEYLLN
||.||.
keeLle
0036282 (Phosphotyrosine protein) phosphatases II 19-185 2e-26 88.1 In-house 4-164 (174) alignment 
Range on Protein: 19-185
Range on HMM: 4-164/174.0
WLYCPRKSDTIIAERFLAFKTPLSnnfhdKMPIECTFQPEMLFEYCKTLKVKLGLWVDLTNTkrfyDRSAVEELGAKYIKLQCRGHGETPSPEqTHSFIE
.. ..  . ..| .|..|.. ||.      ..  . .. .... ...    .|... .....    .|.  |.|| .|..| . .||. ....  ..|..
yinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....lredlerlgiqylylpwpDhgvpdlsi.llefvk

IVDNFINERPFDVIAVHCTHGFNRTGFLIVCYLVERLDC-SVSAALAIFASAR---PPGIYKQDYINELYK
.|.....| |  ...|||..|..|||.|...||..|. . |.  ||......|   |.... ....  ||.
fveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyy
0044763 (Phosphotyrosine protein) phosphatases II 57-187 9.8e-25 82.6 In-house 37-167 (178) alignment 
Range on Protein: 57-187
Range on HMM: 37-167/178.0
PEMLFEYCKTLKVKlgLWVDLTNTKRFY----DRSAVEELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINERPfDVIAVHCTHGFNRTGFLIVCYLV
|.. .|. | |...  ..|.||.... .    |. ..|| | .|... . .||.....|... |.|.......|..  ...|||..|..|.| |...||.
paddlellkelgit..hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekg.gpvlVHCsaGvgRsgtlvaaylm

ERLDCSVSAALAIFASARPpGIYKQDYINELYKRY
 .|..|. .|.. . ..|| ... ..... ||. .
kklglsleeaielvrerRp.ivpnpgqlrqLyefe
0043147 (Phosphotyrosine protein) phosphatases II 31-185 1.1e-24 82.5 In-house 19-155 (172) alignment 
Range on Protein: 31-185
Range on HMM: 19-155/172.0
AERFLAFKTPlsnnfhdkmpieCTFQPEMLFEYCKTLKVKLglWVDLTntKRFYDRSAVEELGAKYIKLQCRGHGETpSPEQTHSFIEIVDNFINERPFD
  ||.|.  |            . .  .. ....|.|....  .|.||  ...||.. .|.|| .|. | .  || . ..|.  .|.|..|......|  
pdrfiatqgp............lrntladfwrmlkelgith..ivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspgg

VIAVHCTHGFNRTGFLIVCYLVErLDCSVSAALAIFASARPPGIYKQDYINELYK
...|||..|..|||.|...||.. |..|.  |.| . ..|| ... ..... ||.
pvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyy
0049260 (Phosphotyrosine protein) phosphatases II 51-187 8.1e-23 76.2 In-house 12-146 (152) alignment 
Range on Protein: 51-187
Range on HMM: 12-146/152.0
IECTFQPEMLFEYCKTLKVKLGLWVDLTNTKRFYDRSAVEELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFiNERPFDVIAVHCTHGFNRTGFLIVCY
| . .  .. ..  . .  .|| .. .. |.....    .| . .|. |..  ||  ....    ...... . ....  ...|||..|..|||.|...|
iatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaay

LVErLDCSVSAALAIFASARPPGIYKQDYINELYKRY
|.. |..|.  |.| . ..|| ... ....  ||...
lml.lgvsleeavalvrekRpgavpnpgqlrflyefe
0049772 (Phosphotyrosine protein) phosphatases II 33-188 1.9e-22 75.8 In-house 85-270 (314) alignment 
Range on Protein: 33-188
Range on HMM: 85-270/314.0
RFLAFKTPLSNNFHDK-----------------------------------------------MPIECTFQPEMLFEYCKTLKvklglwvdltntKRFYD
.|.| ..||.....|                                                 .| . ...|  ... ..||            .. ||
kfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk............eelyd

RSAVEELGAKYIKLQCRGhGETPSPEQTHSFIEIVDNFineRPFDVIAVHCTHGFNRTG-FLIVCYLVERLDCSVSAALAIFASARPpgIYKQDYINELY
.. .|.|| ||. . . . |..|..|.  .|.|.....   ..  ...|||..| .||| |....||. .|..|.  ||. . ..||  |. ..   | .
pelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp..inpnpgfieql

KRYE
..||
eqye
0041856 (Phosphotyrosine protein) phosphatases II 33-182 4.5e-22 74.0 In-house 35-162 (182) alignment 
Range on Protein: 33-182
Range on HMM: 35-162/182.0
RFLAFKTPLSNnfhdkmpiectfQPEMLFEYCKTLkvKLGLWVDLTntKRFYDRSAVEELGAKYIKLQCRGHGETPsPEQTHSFIEIVDNfinerPFDVI
||.|...|| .            .... ... | |  . .. |.||   . |. . .| || .|..|.. .|| .. ......|||.| .     .  ..
rfiatqgplls............tvadflrmlkel..gittivnlt..eelywpellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpv

AVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARPPGIYKQDYINE
.|||..| .|||.|...||...|..|.  |.. . |.|| ..   ...  
lVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyff
0048076 (Phosphotyrosine protein) phosphatases II 65-188 8.1e-22 72.9 In-house 26-140 (145) alignment 
Range on Protein: 65-188
Range on HMM: 26-140/145.0
KTLKVKLGLWVdltntkrFYDRSAVEELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINERpfDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALA
| |.... | .        .... .|.|| .|. | . .||. ...|.  .|.|.......|    ...|||..| .|||.|...||. .|..|.  ||.
kdlgittvlnl.......tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllgvsleeale

IFASARPPGIYKQDYINELYKRYE
 . |.|| ... ..... ||. ..
lvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 66-187 5.7e-21 70.2 In-house 25-140 (144) alignment 
Range on Protein: 66-187
Range on HMM: 25-140/144.0
TLKVKLGLWVDLTNTkrfYDRSAVEELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINERpfDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAI
  | .......||..   |.   .|  | .|..| . .||  ...|.  .|.|.......|    ...|||..|..|||.|...||. .|..|.  ||| 
lkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkklglsleealal

FASARPPGIYKQDYINELYKrY
. |.|| ... ..... |.. |
vrsrrpgavpnpgqlrfLle.y
0040439 (Phosphotyrosine protein) phosphatases II 30-185 2.4e-20 68.7 In-house 52-240 (249) alignment 
Range on Protein: 30-185
Range on HMM: 52-240/249.0
IAERFLAFKTPLSNnfhdkmpiectfQ----PEMLFEYcktlkvKLGLWVDLTNTKRF------------------------------------------
|  ||.|...||..                  .||.|.      . .  |.||.....                                          
ikrrfiatqgPlpe............tvedfwrmlwel......gitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltn

-YDRSAVEELGAKYIKLQcrGHGETPSPEQTHSFIEIVDNFINER-PFDVIAVHCTHGFNRTGFLIVCYLV-----ERLDCSVSAALAIFASARPPGIYK
 || . .. |.  |...    ||  ||.|.. .|||.|.....|  .  ...|||..| .|||..|..||.     ..|. ..  |.. . |.|| ... 
lydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

QDYINELYK
....  ||.
peqyrflye
0037934 (Phosphotyrosine protein) phosphatases II 30-185 9.9e-20 66.6 In-house 42-236 (243) alignment 
Range on Protein: 30-185
Range on HMM: 42-236/243.0
IAERFLAFKTPLSNNFHDkmpiECTFQPEMLFEYcktlkvKLGLWVDLTNTK----------------------------------------RFYDRSAV
. .|. |.  ||.....|          .||.|.      . .  |.||...                                        . .| . .
vtprliatqgPlpetved....dlasfwrmlwel......gitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddl

EELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINE-------RPFDVIAVHCTHGFNRTGFLIVCYLVERL-DCSVSAALAIFASARPP-GIYKQDYI
. |. .|  |   .||  .|||.  .|...| .||.|        .  ...|||..| .||| ||..||. .| ....  |.. . . ||  ..  ....
trlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy

NELYK
  ||.
rflye
0040438 (Phosphotyrosine protein) phosphatases II 24-185 1.5e-19 65.9 In-house 14-270 (317) alignment 
Range on Protein: 24-185
Range on HMM: 14-270/317.0
RKSDTII----------------------------------------------------------------AERFLAFKTPLSNnfhdkmpiECTFQPEM
... |..                                                                  .|.|...||.|         .    .|
ksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpn........tvedFwrm

LFEYcktlkvKLGLWVDLTNTKRFYD----------------------RSAVEELGAKYIKLQC-------------------RGHGETPSPEQTHSFIE
..|.      .... | ||... . .                      .| .|. | .. .|..                     ||  |||..  .|.|
vweq......gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

IVDNFINeRPFDVIAVHCTHGFNRTGFLIVCYLV-----ERLDCSVSAALAIFASARPPGIYKQDYINELYK
.|..... .|  ...|||..| .|||..|..||.     .. ...|  |.. . ..|| ...  ...  ||.
avreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyd
0042113 (Phosphotyrosine protein) phosphatases II 30-185 3.8e-19 64.5 In-house 50-237 (245) alignment 
Range on Protein: 30-185
Range on HMM: 50-237/245.0
IAERFLAFKTPLSNNFH-----------------------------DKMPIECTFQPEMLFEYCKTLKVKLGLWVDLTNTKRfyDRSAVEELGAKYIKLQ
| ..|.|.  ||.....                               .| ..... . .. .... ... ...|   . ..  ...  .  .  |  | 
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtn..lgddesrevihyhylp

CRGHGETPSPEQTHSFIEIVDNFINERPFDVIAVHCTHGFNRTGFLIVCYLV-----ERLDCSVSAALAIFASARPPGIYKQDYINELYK
. .||.....|.  .|.|.|.....| .  ...|||..| .||| .|..||.     ..|. |.  |.. . | ||  .  ....  ||.
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflye
0045450 (Phosphotyrosine protein) phosphatases II 32-185 1.4e-18 63.2 In-house 107-298 (307) alignment 
Range on Protein: 32-185
Range on HMM: 107-298/307.0
ERFLAFKTPLSNnfhdkmpiectfQPEMLFEYCKTLkvKLGLWVDLTNTK-------------------------RFYDRSAVEELGAKYIKLQCR----
 .|.|...||..             .|  ..... .  . .. |.||...                         .... .  ...   ......     
rkfIatqgPlpe............tvedFwrmlweq..gvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtg

--------------GHGETPSPEQTHSFIEIVDNFINER-PFDVIAVHCTHGFNRTGFLIVCYLVERLD--------CSVSAALAIFASARPPGIYKQDY
              .||  ||.|.. .|||.|.....|  .  ...|||..| .||| .|..||. |.         ...  |.. . . || ..  ...
esrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeq

INELYK
.  ||.
yrflye
PTEN_1 77-192 7.4e-18 60.1 In-house 74-193 (196) alignment 
Range on Protein: 77-192
Range on HMM: 74-193/196.0
LTNTKRF----YDRSAVEELGAKYIKLQCRGHGeTPSPEQTHSFIEIVDNFINERP-FDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARP
|.. .      || .  .. | .|...  . || .|| .. . ... ... . ..|   |..|||..| .|.|... .||...   ..  ||......||
lseeeelsgrsydleeffksgveylhfpieDhg.apslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRp

PGIYKQDYINELYKRYEDTNA
||   . . ..| . .....|
pgapnspsqerlleyfaella
0051082 (Phosphotyrosine protein) phosphatases II 73-180 4.6e-17 57.5 In-house 36-142 (151) alignment 
Range on Protein: 73-180
Range on HMM: 36-142/151.0
LWVDLTNTK-RFYDRSAVEELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINeRPFDVIAVHCTHGFNRTGFLIVCYLVErLDCSVSAALAIFASARP
  |.|.... | |. . ..||| ... ... .. ... |. .....|... ...  .  ...|||..| .|||.|...||.  |..|. .||. . . ||
tivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrp

PGIYKQDYI
  ..  . .
gvvqpnqqf
0046846 (Phosphotyrosine protein) phosphatases II 59-184 1.6e-16 56.0 In-house 42-166 (176) alignment 
Range on Protein: 59-184
Range on HMM: 42-166/176.0
MLFEYCKTLKVKLGLWVDLTNTKRFYDRSAVEELGAKYIKLQCRGHGETPSpEQTHSFIEIVDNFINERpfDVIAVHCTHGFNRTGFLIVCYLVER-LDC
||.|.  |. | |  .|.|   | ... . .|.|| .|. |  . ||  .. |. ....|.......|    ...||| .| .||| |...||.|.  . 
mlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllelekgl

SVSAALAIFASARP-PGIYKQDYINELY
||  ||| . . ||   .  ....  ||
sveealalvreqRplgavqtpeQyrfly
subfamily_CDC14_pd Subfamily CDC14 27-174 3.1e-16 54.1 In-house 173-308 (328) alignment 
Range on Protein: 27-174
Range on HMM: 173-308/328.0
DTIIAERFLAFKTPLSNNFHDKMpiECTFQPEMLFEYCKTLKVKLglWVDLtNtKRFYDRSAVEELGAKYIKLQCRgHGETPSPEQTHSFIEIVDNFine
..|. ..|||.  | ...  ..     . .|| |.|| .. .|.    | | | |. ||..  .. | ..  |     | ||| .  ..|.||...    
nwivPdkflalagPhnkskledg..yplhaPeklleyfrknnvtt..vvrL.n.kklYdakkftdaGfdhkDlffi.DGstPsdaivkkfleiaeka...

rpFDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARPPGI
     |||||  |. ||| || |||...   . . |.| .  .||  .
..eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsv
0039614 (Phosphotyrosine protein) phosphatases II 33-185 9.6e-15 50.3 In-house 102-283 (297) alignment 
Range on Protein: 33-185
Range on HMM: 102-283/297.0
RFLAFKTPLSNnfhdkmpiectfQ----PEMLFEYcktlkvKLGLWVDLTNTKRF--------------------YDRSAVEELGAK-------------
.|.|...||..                  .|..|.      .    | ||...                      . ..  .. | .             
kfIatqgPlpe............tvedFwrmvweq......gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesr

----YIKLQCRGHGETPSPEQTHSFIEIVDNFINER-PFDVIAVHCTHGFNRTGFLIVCYLV-----ERLDCSVSAALAIFASARPPGIYKQDYINELYK
    .  .    ||  ||.|.  .|.|.|.....|  .  ...|||..| .||| .|..||.     .. . .|  |.. . ..|| ..   ...  ||.
tvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyd
0043336 (Phosphotyrosine protein) phosphatases II 77-185 9.4e-14 47.0 In-house 162-271 (278) alignment 
Range on Protein: 77-185
Range on HMM: 162-271/278.0
LTNTKrFYDRSAVEELGAKYIKLQcrGHGETPSPEQTHSFIEIVDNFINeRPFDVIAVHCTHGFNRTGFLIVCYLV-----ERLDCSVSAALAIFASARP
|. |.  .|    . ..  |..     ||  .|...  .|...|.....  .  ...|||..| .||| .|..||.      ..  ..  |.. . . ||
levtn.lgdgesrtvthyhylgwp..dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRp

PGIYKQDYINELYK
  .  ....  ||.
gavqtpsqyrflye
0045098 (Phosphotyrosine protein) phosphatases II 68-185 1e-13 46.8 In-house 130-266 (278) alignment 
Range on Protein: 68-185
Range on HMM: 130-266/278.0
KVKLGLWVDLTNTKRFYDRSAVEELGAKYIKL-QCRGHGETPSP--EQTHSFIEIVDNFIN------------ERPFDVIAVHCTHGFNRTGFLIVCYLV
 ..    ..|. |  .. |.  |..| .....     ||  ..|   .  ...| ......            . .  ...||| .| .||| |...||.
vlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylm

ERL---DCSVSAALAIFASARPP-GIYKQDYINELYK
 .|    ...  |.. . | ||   .  .. .. ||.
lelleggvdlleavkelrsqRpglavqnleqyrflye
0046845 (Phosphotyrosine protein) phosphatases II 99-181 3.6e-13 45.0 In-house 173-264 (284) alignment 
Range on Protein: 99-181
Range on HMM: 173-264/284.0
LQCRGHGETPSPEQTHSFIEIVDNFINE-RPFDVIAVHCTHGFNRTGFLIVCYLVERL--------DCSVSAALAIFASARPPGIYKQDYIN
..   ||  ||||.  .|...|......  .  .|.||| .| .||| .|...|. ..         ..|  |.. . . ||  .   . . 
tswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyr
DSPc Dual specificity phosphatase, catalytic domain 91-185 4e-12 41.2 Pfam-A 37-129 (133) alignment 
Range on Protein: 91-185
Range on HMM: 37-129/133.0
ELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINERpfDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARpPGIYKQ-DYINELYK
.   .|.... . . ||   ..  . .|.........    ..|||..| .|.. ||..|| ..  .|.. |.... . | . | ..  .. .|..
kseieylripvedetetkiskeleeavefiekaeqkg..kkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skispnagflrqLle
DSPc Dual specificity phosphatase, catalytic domain 91-185 4e-12 41.2 In-house 37-129 (133) alignment 
Range on Protein: 91-185
Range on HMM: 37-129/133.0
ELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINERpfDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARpPGIYKQ-DYINELYK
.   .|.... . . ||   ..  . .|.........    ..|||..| .|.. ||..|| ..  .|.. |.... . | . | ..  .. .|..
kseieylripvedetetkiskeleeavefiekaeqkg..kkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr.skispnagflrqLle
PTPc_motif_SM00404 90-185 5.9e-12 40.7 In-house 43-136 (140) alignment 
Range on Protein: 90-185
Range on HMM: 43-136/140.0
EELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINERpfDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARpPGIYKQ-DYINELYK
|. | ...... . .....  ..  . .....|.....    . |||..| .|.. ||..|| ..  .|...|. .. . | | | ..  ....|..
ensgfqilqiplddnekdklskyldkvldfienaekkg..gkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR.piispnlnfvrqLie
0047943 (Phosphotyrosine protein) phosphatases II 101-184 7.6e-12 40.7 In-house 176-265 (273) alignment 
Range on Protein: 101-184
Range on HMM: 176-265/273.0
CRGHGETPSPEQTHSFIEIVDNFINER--PfDVIAVHCTHGFNRTGFLIVCYLV-----ERLDCSVSAALAIFASARPPGIYKQDYINELY
   ||  ||.|.  .|||.|......   .  ...||| .| .||| .|...|.     ..   .|  |.. . | || ...  ...  ||
wpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0048567 (Phosphotyrosine protein) phosphatases II 104-179 1.1e-11 39.3 In-house 48-127 (157) alignment 
Range on Protein: 104-179
Range on HMM: 48-127/157.0
HGeTPSPEQTHSFIEIVDNFIN--ERPFDVIAVHCTHGF---NRTGFLIVCYLVERLDCSVSAALAIFASARPPGIYKQDY
.|  ..  ....|| ....|..  |    .|||||..|     ||..|| |||. .|. . . |.|... .||. ..  | 
fG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrda
0050432 (Phosphotyrosine protein) phosphatases II 102-179 2.3e-11 39.1 In-house 208-287 (308) alignment 
Range on Protein: 102-179
Range on HMM: 208-287/308.0
RGHGETPSPEQTHSFIEIVDNFINErpfDVIAVHCTHGFNRTGFLIVCYLV-----ERLDCSVSAALAIFASARPPGIYKQDY
  ||  ||||.  .|.|.|......    .|.||| .| .||| .|...|.     .   ..|  |.. . . ||  .   ..
pdhgvPpspeilldflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq
0051429 (Phosphotyrosine protein) phosphatases II 72-186 2.7e-11 39.1 In-house 47-220 (272) alignment 
Range on Protein: 72-186
Range on HMM: 47-220/272.0
GLWVDLTNTKRFYDRS-AVEELGAKYIKLQCRGHGETPSP---------------------------------------------------EQTHSFIEI
   |||...          .  |..|. | . ......                                                     |. ....|.
ktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellel

VDNfinerpFDVIAVHCTHGFNRTGFLIVCYLVErLDCS--------------VSAALAIFASARPPGIYKQDYINELYKR
. .         . |||..| .|||......|.  |. |              . .|..   ..||  .  .. .  ||. 
lld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyea
subfamily_DSP23_pd Subfamily DSP23 107-176 4.2e-11 37.7 In-house 64-131 (148) alignment 
Range on Protein: 107-176
Range on HMM: 64-131/148.0
TPSPEQTHSFIEIVDNfINERPfDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARPPGIYK
 |..||   |...|..  .|.  . ..|||  |. ||| .. ||||   . . . |.|     ||  .  
ppaleqvvefvrvvee.aeekn.eavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvet
subfamily_PTEN_pd Subfamily PTEN 93-170 4.6e-11 38.0 In-house 79-156 (184) alignment 
Range on Protein: 93-170
Range on HMM: 79-156/184.0
GAKYIKLQCRGHgETPSPEQTHSFIEIVDNFINERPFDVIAVHCTHGFNRTGFLIVCYLVERLDCSVS-AALAIFASAR
  . .....  | ..|. |  ....| ......| .  |..|||  |  ||| |||.||...| .. .  ||..||.||
dgrvavypfdDh.nppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
0036941 (Phosphotyrosine protein) phosphatases II 104-179 3.1e-10 35.3 In-house 181-265 (297) alignment 
Range on Protein: 104-179
Range on HMM: 181-265/297.0
HGETPSPEQTHSFIEIVDNFINER-PFDVIAVHCTHGFNRTGFLIVCYLV--------ERLDCSVSAALAIFASARPPGIYKQDY
||  .||..  .||| |......  .  .. ||| .| .|.| .|...|.        ..  ...  |.  . . ||  .   . 
hgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleq
0051299 (Phosphotyrosine protein) phosphatases II 102-180 3.3e-10 35.4 In-house 193-275 (288) alignment 
Range on Protein: 102-180
Range on HMM: 193-275/288.0
RGHGETPSPEQTHSFIEIVDNFINeRPFDVIAVHCTHGFNRTGFLIVCYLV-----ERLDCSVSAALAIFASARPPGIYKQDYI
  ||  .|||.  .|...|.....  .  ...||| .| .||| .|...|.     ..  ..|  |.. . . ||  .   . .
pdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqy
subfamily_PTPDC1_pd Subfamily PTPDC1 107-183 6.4e-10 33.8 In-house 95-168 (182) alignment 
Range on Protein: 107-183
Range on HMM: 95-168/182.0
TPSPEQTHSFIEIVDNFINERpfdVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARPPGIYKQDYINEL
..| |.    . .|.  ..|     .||||  |  ||| || ||||   . . . |. .  | ||  |. .. .. .
vasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelv
subfamily_PTPMT1_pd Subfamily PTPMT1 89-190 6.3e-08 27.3 In-house 69-167 (171) alignment 
Range on Protein: 89-190
Range on HMM: 69-167/171.0
VEELGAKYIKLQCRGHGETPSPEQTHSFIEIVDNFINERpfDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARPPgIYKQDYINELYKRYE
 ..|| ....|.   . |.|. |. .  .|........   . . |||  |  |.. |. |||. .  .|   || . .. |.  | ....  .. ..||
wkklgveqlqlatvDfteapdleklekgvefiekvaskg..krvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRki.irlakkqwkalqeye

DT
..
ek
subfamily_PRL_pd Subfamily PRL 83-154 4.1e-07 24.2 In-house 45-115 (151) alignment 
Range on Protein: 83-154
Range on HMM: 45-115/151.0
FYDRSAVEELGAKYIKLQCRgHGETPSPEQTHSFIEIVDNFINERPFDVIAVHCTHGFNRTGFLIVCYLVER
 || ...|. | . . |.    | .|. |  ....|.. .  .|.|  ..||||  |. |.  |..  |.| 
tydteklekegievldlafd.dGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea
subfamily_VSP_pd Subfamily VSP 82-170 7.5e-07 23.3 In-house 85-170 (212) alignment 
Range on Protein: 82-170
Range on HMM: 85-170/212.0
RFYDRSAVEElgaKYIKLQCRGHgETPSPEQTHSFIEIVDNFINERPFDVIAVHCTHGFNRTGFLIVCYLVERLDCSV-SAALAIFASAR
| ||..  ..   . ....   | . |. |.  .| ..| ..... . .|.|.||  | .||| .. ..|..   ..    .|  |.. |
raydekyfnn...rvkriliddh.nvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerr
PTPc_DSPc_SM00012 107-152 2.9e-06 22.8 In-house 16-62 (105) alignment 
Range on Protein: 107-152
Range on HMM: 16-62/105.0
TPSPEQTHSFIEIVDNFINERPF-DVIAVHCTHGFNRTGFLIVCYLV
  ...   .... |... |..     . ||| .| .||| ... ...
PeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldil
subfamily_DSP19_pd Subfamily DSP19 116-183 5.6e-06 20.8 In-house 74-143 (152) alignment 
Range on Protein: 116-183
Range on HMM: 74-143/152.0
FIEIVDNFINERPF--DVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARPPGIYKQDYINEL
... . .||.|      .. |||  |  |.  ... ||... . |.. ||    .|||.    . .|. |
ylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPneGFikqL
subfamily_DSP12_pd Subfamily DSP12 129-183 8.5e-06 20.2 In-house 82-136 (155) alignment 
Range on Protein: 129-183
Range on HMM: 82-136/155.0
FDVIAVHCTHGFNRTGFLIVCYLVERLDCSVSAALAIFASARPPGIYKQDYINEL
 . . |||. |  |   ... ||. . ..|.. || .  ...|     . ... |
egavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQL