Gene EDTP in Drosophila melanogaster

Synonym: BcDNA:LD16029, CG9554, CLI, CLIFT, Dmel\CG9554, EY2-1, EYA, Eya, cli, cli/eya, dEYA, del1, eay, ey-2, Dmel_CG9554, eya

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR14
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP029_AA protein Get Run
DmelP029_AA_341-503 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR14_pd Subfamily MTMR14 45-509 1.1e-193 634.9 In-house 1-357 (357) alignment
Range on Protein: 45-509
Range on HMM: 1-357/357.0
KKCEYLFKLDYSLIELDNTNGLLSPRYPGRILIPEYEHGhmaktlvpgnglfgqvgggvggggssgttatatplnssA---Gstgsegvgiqafvtfanp
||.|.|.| ||||...||||| |..|||...||.|||.|                                      .   |                  
kkveellkrdyslsvidntnGelcsrypvkllileyelg......................................egseg..................

lqtqqqhplqqqypsqqmhplhaqypsqqphplqqqqqqpsqqqpQNTIYEDQYDIQRMRELVTMAKYARCRQRFAVPVIMYRGKYICRSATLSVMPETY
                                             .....|..||.||.|||.|.|||||||.||.||||...||.|||||||||..|.|
.............................................ekelvesaydvqrlrelltkakyarcrerfvvpvilldgknicrsatlsvaaeiy

GRkvvdyaydclSGGNYTAPNGEENDADSTDESLITHMHDQAQSQFSYDEVIKSDIQLLHTLNVSTIVDLMVENRKIKYFMAVSSSEKADPNKHYKSFNL
||          || ||.|..|||.|||..||.|||...|||..|...|.|.||||.||.||.|..|||||||..|.||..|||||||||..|.||.|.|
gr..........sGlnylasggeeadadkedeelitakedqaeeqalldrvrksdikllktlkvklivdlmvekkkvkyglavsssekadkekrykdftl

LSLPYPGCEFFKKFRDNNYMARNLHYNWKQTFNDANINIPNMgPAADIDVAWSEYRDWDLVAITQNYLRATLKYVQEEN-SGLLIHCISGWDRTPLFVSL
|||||||.|||||||||.|.|.||.|||||...||..|||.. .||..|..||||..|||||.|||||...||||.|.. ||||.|||||||||||||||
lslPyPGveffkkfrdnkysaknlfynWkqdevdaelniPdk.laasvdidwseykkWdlvaltqnylklllkyvkededsGllvhcisGWdrtPlfvsl

VRLSLWADGLIHQSLNAMQMAYFTLAYDWYLFGHQLPDRLKRGEDIMFFCFHVLKFITDEEFSIVEHRK
.||||||||||||||.|....|.|.||||.|||||||||||.||.|.||||.||||||.|||||.|.||
lrlslWadglihqslsaaellyltvaydWflfghqlpdrlkkgeeilffcfdvlkfitseefsiletrk

0040695 (Phosphotyrosine protein) phosphatases II 35-574 5.2e-62 203.7 In-house 5-384 (388) alignment
Range on Protein: 35-574
Range on HMM: 5-384/388.0
EEGTAEYDISKKCEYL-FKLDYSLIELDNTNGLLSPRYPGRILipeyehghmaktlvpgnglfgqvgggvggggssgttatatplnssagstgsegvgiq
|||. .||| .....| ..||.  |   | |. |.|.||....                                                         
eegwslydilrelkrlglgldlwrisivNenyelcpsYPallv.........................................................

afvtfanplqtqqqhplqqqypsqqmhplhaqypsqqphplqqqqqqpsqqqpqntiyedqydIQRMRELVTMAKYARCRQRFAVPVIMY----RGKYIC
                                                               .... .  .....||.|... .||..|    .|....
...............................................................VPksisdellkrvarfrskgriPvlsyrhpnngavll

RSATLSVmpetygrkvvdyaydclsggnytapngeendadstdeslithmHDQAQSQFSYDEVIKSDIQLLHTLNVSTIVDLMvenRKIKYFMAVSSSEK
||... |                                           . . ...............||..|.. .||||.   .|....... ....
Rssqplv...........................................glllsrsledeklleailkllpnlskllivdlr...pklnalanralggg

ADPNKHYKSFNLLSLPYPGCEFFKKfrdnnymarnlhynWKQTFNDANINIPNMGpaaDIDVAWSEYRDWDLVAITQNYLRATLKYVQEENSGLLIHCIS
 .. ..|....|..|..|.......              . |.. ||..|.|..    .. ....|.. .||. ......  ..|... .||..|.||..
venedaypnaeliflnipnihvvre..............slqklldaclnvpdsl...nllslleesgwldliklilelavlivklldlgnssvlvhcsd

GWDRTPLFVSLVRLSLWADgliHQSLNAMQMAyftLAYDWYLFGHQLPDRLKRGED---------------------------IMFFCFHVLKFITDEEF
|||||....||..|.|...   ...|. .|.    ....|..|||...|||...|.                           ...|....|.|..|. .
gwdrtsqlssLaqllldPy...YRTleGFqvL...iekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhly

SIV--------EHRKRTKTSSSSGSSVIVIKSDCCDDeplkdpftlncrDYILSFDQDSN-DSYSNCSNCDMSITDNFYAT
| .        |..... . |....|.. .   ....             . ...|..|.   . ..|..|. . ...| .
scrfgtFlfnsekerlelsvsertlslwsyllsrkse............flnplYdpsslevllpslsvldlllWleyylr

0051429 (Phosphotyrosine protein) phosphatases II 295-454 1e-12 43.8 In-house 36-200 (272) alignment
Range on Protein: 295-454
Range on HMM: 36-200/272.0
SDIQLLHTLNVSTIVDLMVEN--RKIKYFMAVsssekadPNKHYKSFNLLSLPYPGCEFFKKFRDNNYMARNLHYNwkqtfNDANINIPNMGPAADIDVA
 |.. |..|...|||||. |.   . |...         |. .|  ...|.  .|  .... .  . ..   |.|       .  . .  ... .   | 
adfwrlkelgiktivdLrseeErgrlkcdryw.......pgirylhlpilddsaptilygalrvtllseellldyi.....lrellltlllsagearevm

WSEYRDWDLVAITQNYLRATLKYVQEeNSGLLIHCISGWDRTPLFVSLVRLSLWAD----------------GLIHQS
.  |.||    . |..|.. |..... .  .|.|| .|.||| ..| |..| |  .                . ... 
hlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

0051082 (Phosphotyrosine protein) phosphatases II 295-444 3.5e-10 35.2 In-house 24-116 (151) alignment
Range on Protein: 295-444
Range on HMM: 24-116/151.0
SDIQLLHTLNVSTIVDLMVENRKI---KYFMAVSssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndaninipnmgpaadIDV
 ...||..|...|||.|. |       .|. . .                                                               |.|
dflellkelgiktivnlrseeergycpeylpelg...............................................................iev

AWSEYRDWDLVAI--TQNYLRATLKYVQEE-NSGLLIHCISGWDRTPLFVSLVRLS
 .  . ||.   .  ... ... |.....  |  .|.|| .|..|| ..| |... 
lhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml

subfamily_MTMR3_pd Subfamily MTMR3 414-485 8.2e-09 27.7 In-house 263-328 (442) alignment
Range on Protein: 414-485
Range on HMM: 263-328/442.0
KYVQEENSGLLIHCISGWDRTPLFVSLVRLSLwaDGlIHQSLNAMQMayfTLAYDWYLFGHQLPDRLKRGED
. |..|.  .|.||  |||||.  |.| .| |  |   ...|. ...    .  .|  |||.. ||   ||.
eavdkegrpvlvhCsdGWdrttqivalaklll..dp.yyrtleGfkv...lvereWldfGhkfadrcghgen

0044763 (Phosphotyrosine protein) phosphatases II 294-440 2.9e-08 29.0 In-house 38-130 (178) alignment
Range on Protein: 294-440
Range on HMM: 38-130/178.0
KSDIQLLHTLNVSTIVDLMVENRKIKYFMAV------SssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndaninipnmgpAA
 .|..||. |....||.|  | .  .. .        .                                                              
addlellkelgithivnlteelelgflkcdpywpeeag............................................................iq

DIDVAWSEYRDWDLVAITQNYLRATLKYVQEENSGLLIHCISGWDRTPLFVSL
 . . .. . . || ..... ...  ....|...  |.||  |..|....| .
ylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaa

0045098 (Phosphotyrosine protein) phosphatases II 290-443 3.2e-08 28.8 In-house 74-229 (278) alignment
Range on Protein: 290-443
Range on HMM: 74-229/278.0
DEVIKSDIQLLHTLNVSTIVDLM--VENRKIKYFMAVSSsekadpnKHYKSFNLLSLPYPGCEFFkkfrdNNYMARNLHYNWK----QTFNDANINIPNM
.. . .....|. |....|| |.  ||. ..|...   .       .... .. ... .  .| .     ..|  | |..       ...  ..... ..
pstvadfwrmlwelgitvivmltelvelgrekcaqywpe.......ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhy

GPAADIDVAWSE--YRDWDLVAITQNYLRATLKYV------QEENSGLLIHCISGWDRTPLFVSLVRL
 |  | .|  ..     ..|.   ...|.. ....      ....   |.||  |..||  .| .  .
lpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylm

subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 403-521 5.5e-08 24.4 In-house 206-290 (404) alignment
Range on Protein: 403-521
Range on HMM: 206-290/404.0
AITQNYlRATLKYVQEENSGLLIHCISGWDRTPLFVSLVRLslWADGlIHQSLNAMQMayfTLAYDWYLFGHQLPDRLKRgedimffcfhvlkfitdeef
 . ..     .. ...|.|  |.||. |||||.  .||..|   .|   .. ... ..    .  .|  |||   .| ..                    
lllegs.kriveliekekssvlvhcsdgwDrtsqlsslsql..lldp.yyrtiegFiv...liekewlsfGhkfaqRigq....................

sivehrkRTKTSSSSGSSV
       .|..||.  | .
.......ttekssdersPi

subfamily_MTMR1_pd Subfamily MTMR1 414-485 5.7e-08 24.4 In-house 206-271 (389) alignment
Range on Protein: 414-485
Range on HMM: 206-271/389.0
KYVQEENSGLLIHCISGWDRTPLFVSLVRLSLwaDGlIHQSLNAMQMayfTLAYDWYLFGHQLPDRLKRGED
. |..|..  |.||  |||||  ..||  | |  |   ..... ...    .. .|  |||.. .|| .|..
ekvetektsvlvhcsdGWDRtaqltsLamlll..Ds.yyRtieGfev...liekeWlsfGHkfkeRlghgdk

0043147 (Phosphotyrosine protein) phosphatases II 286-441 7.3e-08 27.8 In-house 26-121 (172) alignment
Range on Protein: 286-441
Range on HMM: 26-121/172.0
QFSYDEVIKSDIQLLHTLNVSTIVDLMvENrkikyfmavsssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndanINIPNMGP
|. ... . .....|..|....||.|. |                                                                ..|    
qgplrntladfwrmlkelgithivnlt.el..............................................................lydpelle

AADIDVAWSEYRDWDLVaiTQNYLRATLKYVQE-----ENSGLLIHCISGWDRTPLFVSLV
  .| . .  . | .    . ..|. .|....|     ..   |.||  |..||...| . 
rlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRtgtlvaay

0040439 (Phosphotyrosine protein) phosphatases II 286-443 1.2e-07 27.1 In-house 60-202 (249) alignment
Range on Protein: 286-443
Range on HMM: 60-202/249.0
QFSYDEVIKSDIQLLHTLNVSTIVDLMVENRK--IKyfmavsssekadpnkhyksfnlLSLPYPGcEFFKKFrdNNYMARNLHYNWKQTFNDANINIPNM
|.  .| .......|. |....||.|. . ..  .|                          .|  . ....  .... ..|....|. .   .. . |.
qgPlpetvedfwrmlwelgitvivmLtslvelgrek......................caqywpl.ggsley..gdftvtllsvevkddytvrtleltnl

GPAADIDVAWSEYRDWDLVAIT--QNYLRATLKYVQE------ENSGLLIHCISGWDRTPLFVSLVRL
.   .. | .  | ||    .    . | . ...|..      ... .|.||  | .||..|. .  .
ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

Myotubularin-like phosphatase domain 208-527 1.3e-07 23.8 Pfam-A 73-307 (353) alignment
Myotubularin-like phosphatase domain 208-527 1.3e-07 23.8 In-house 73-307 (353) alignment
0049260 (Phosphotyrosine protein) phosphatases II 286-441 1.4e-07 26.8 In-house 15-110 (152) alignment
Range on Protein: 286-441
Range on HMM: 15-110/152.0
QFSYDEVIKSDIQLLHTLNVSTIVDLMVENRKIKYFMAVSSsekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndaninipnmgp
|. ... .......|..|...||| |. .  . |....                                                              
qgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................................

aADIDVAWSEYRDWDLVAITQNYLRATLKYVQEENSGLLIHCISGWDRTPLFVSLV
   . . |  .  .||  . .  |..  |. ....   |.||  | .||...| . 
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaay

0041856 (Phosphotyrosine protein) phosphatases II 291-441 7.8e-07 24.3 In-house 45-130 (182) alignment
Range on Protein: 291-441
Range on HMM: 45-130/182.0
EVIKSDIQLLHTLNVSTIVDLMvenrKIKYFMavsssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndaninipNMGPAADID
. . .....|. |...|||.|        |.                                                            .  . . | 
stvadflrmlkelgittivnlt....eelywp...........................................................ellerlgiq

VAWSEYRDWDLVAitQNYLRATLKYVQEENSGLLIHCISGWDRTPLFVSLV
. .    |..      . | . .. |.||.   |.||  | .||. .| . 
ylylpwpDhgvpd..ldelldfieevleeggpvlVHCsaGvgRtgtlvaay

0049772 (Phosphotyrosine protein) phosphatases II 392-446 1.6e-06 23.6 In-house 187-240 (314) alignment
Range on Protein: 392-446
Range on HMM: 187-240/314.0
AWSEyRDWDlvaiTQNYLRATLKYVQE--ENSGLLIHCISGWDRTP--LFVSLVRLSLW
 ..   ...    . ..... |....|  ... .|.|| .|..||.  ... .. . |.
pvpD.gsap....lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllg

0042113 (Phosphotyrosine protein) phosphatases II 286-443 1.9e-06 23.0 In-house 58-199 (245) alignment
Range on Protein: 286-443
Range on HMM: 58-199/245.0
QFSYDEVIKSDIQLLHTLNVSTIVDLMVENRK--IKyfmavsssekadpnkhyksfnllS-----LpyPGCEFFkkfrdNNYMARNLHYNWKQTFNDANI
|.  .| ..  ...|. |...|||.|. |  .  .|                       .     |   .   .     .... ..| .......   ..
qgPlpetvedfwrmlwelgittivmLteeeelgrvk.......................caqywpl..geslty.....gdftvtllseehlddytvrtl

NIPNMGPAADIDVAWSEYRDWD------LVAITQNYLRATLKYVQ-EENSGLLIHCISGWDRTPLFVSLVRL
.. |.|      |    | .|.      |... .. |.. .|...  .|  .|.||  | .|| .|. . ..
evtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

YppG YppG-like protein 139-202 2.9e-06 14.4 Pfam-A 22-88 (112) alignment
Range on Protein: 139-202
Range on HMM: 22-88/112.0
ANPLQTQ-QQHPLQQQYPSQQMHPLHAQYPsqQPHPLQQQQQ-QPSQQQP---QNTIYEDQYDIQRMRE
 .. |.| |. . .... .||...   ..|  .| | |..|| |||. .    | .  . ..|...| .
qqqpqqqqqpeeassppqkqqaneappkap..nPyPkqspqqqqpskfssilsqFknedGnfDfnKmmn

0037934 (Phosphotyrosine protein) phosphatases II 284-445 2.9e-06 22.5 In-house 48-203 (243) alignment
Range on Protein: 284-445
Range on HMM: 48-203/243.0
QSQFSYDEVIKS----DIQLLHTLNVSTIVDLMVEN--RKIKYFMAVSssekadP-NkHYKSFNLLslpypgceFFKKFRDNNYMARNLHYNWKQTFNDA
 .|.  .| ...    ....|. |....||.|. .    ..|...  .          .|. |           . .    ..|. |.|.. .... .  
atqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp......gev.tygdftvt........llseehlddytvrtlllenldlddlt

ninipnmgpAADIDVAWSEYRD---WDLVAITQNYLRATLKY--------VQEENSGLLIHCISGWDRTPLFVSLVRLSL
           .| . .    |    | ... ...|... ..        .  ... .|.||  | .|| ... .  . |
.........rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmll

subfamily_MTMR6_pd Subfamily MTMR6 414-479 3e-06 18.8 In-house 217-276 (397) alignment
Range on Protein: 414-479
Range on HMM: 217-276/397.0
KYVQEENSGLLIHCISGWDRTPLFVSLVRLslwadgLIHQSLNAMQMAYFTLAYDWYLFGHQLPDR
|.|.||.   |.||  |||||   .||  |      |. .   ...     .  .|  |||.. .|
kavaeegasvlvhcsdGwdrtaqvcslasl......lldpyyrtikGflvliekewlsfGhkfser

0048179 (Phosphotyrosine protein) phosphatases II 293-443 3.9e-06 22.2 In-house 18-106 (144) alignment
Range on Protein: 293-443
Range on HMM: 18-106/144.0
IKSDIQLLHTLNVSTIVDLMVENRKIKYFMAvsssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhyN------------------------
  .|..||. |...|...|. |  .  .                                               .                        
taldlellkklgittvinlteeyepeflere............................................giqylhlpwpDhgvpdllelllefl

-----WkqtfndaninipnmgpaadidvawseyrdwdlvaitqnylratlkyvQEENSGLLIHCISGWDRTPLFVSLVRL
     .                                               .||.   |.||  | .||...| . ..
efieea...............................................leeggpvlVHCsaGvgRtgtlvaaylm

0048076 (Phosphotyrosine protein) phosphatases II 293-443 9.9e-06 20.8 In-house 18-104 (145) alignment
Range on Protein: 293-443
Range on HMM: 18-104/145.0
IKSDIQLLHTLNVSTIVDLmvenrkikyfmavsssekadpnkhyksfnllslpypgceffkkfrdnnymarnlhynwkqtfndanINIPNMGPAADIDVA
  .|..||. |.. |...|                                                                   . ..   . .| . 
taldlellkdlgittvlnl..................................................................tselellerlgiqyl

WSEYRDWDLVAITqNYLRATLKY---VQEENSGLLIHCISGWDRTPLFVSLVRL
.    |..   .. ..|.. |..   ...|.   |.||  | .||...| .  .
ylpwpDhgvpdll.ellleflefieealkeggpvlVHCsaGvgRtgtlvaaylm