Gene Pten in Drosophila melanogaster

Synonym: CG5671, DPTEN, Dmel\CG5671, PTEN, PTEN3, dPTEN, dPten, dpten, pten, Dmel_CG5671, Pten

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP035_AA protein Get Run
DmelP035_AA_11-216 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTEN_pd Subfamily PTEN 12-193 6.3e-87 285.3 In-house 2-182 (184) alignment 
Range on Protein: 12-193
Range on HMM: 2-182/184.0
IRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPApDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQR
.|..||||..|.||.|.||||.||..||||||||| .|||.|.||.||||.|.||..|..|||||||.|||.|| .||.||||||||||||||..||...
lrkivskkkkrfkedgldLDlsyiteniiamgyPa.eklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplellee

FCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSS
...|...||.||..|||.|||||||||||..|.|||. |.. ..|.|||....|.|||..||||||||||||.|..||. ..
ivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee
subfamily_VSP_pd Subfamily VSP 9-190 1.1e-61 202.4 In-house 13-198 (212) alignment 
Range on Protein: 9-190
Range on HMM: 13-198/212.0
SNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKlEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIEL
 ...|..||. . ||.. |.||||||. . |||| .|.  | . |.|| ...| ..|.. | .|||..||||||.|| . |. ||     |||| |..| 
ekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGk.qslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpklee

IQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDR-----KGVTIPSQRRYVQYFSKLV
.  |. .|  ||..| .||.|.||| |||||||..||.|. |.| ..|.|.| .. |.||.       .||  |||.|||.|. ...
llvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvk
PTEN_1 19-191 2.1e-50 166.3 In-house 9-193 (196) alignment 
Range on Protein: 19-191
Range on HMM: 9-193/196.0
KRIRYKEKGYDLDLTYINDNIIAMGYPAPDK-----LEGLFRNRLEDVFKLLEENHAQH-YKIYNLCSERS-----YDVAK-FRGRVA--VYPFDDHNPP
.  .. . . .||||||.. |||||..  ..      |||.|..|.|| ..|....... . ..||..|.      ||  . |...|    .|..||..|
skknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgap

TIELIQRFCSDVDMWLKEDS-SNVVAVHCKAGKGRTGTMICAYLVFSGIkKSADEALAWYDEKRTKDRKGvtIPSQRRYVQYFSKLVC
... ....| ... ||..|.  |||.||||||.||.||...|||...|   .|||||... |||.. ..   .|||.|...||..|  
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaella
subfamily_Tensin_pd Subfamily Tensin 21-195 3.7e-47 153.3 In-house 2-176 (189) alignment 
Range on Protein: 21-195
Range on HMM: 2-176/189.0
IRYKEKGYDLDLTYINDNIIAMGYPApDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLcSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWL
 || |. .||||||| . |||. .|| . ||  .|. |.|| |||...| ..| ..|| ||..||. |.  .|  . . |.  |..| .   | ..| ||
vryveekvdldltyiteriialsfpa.egleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWl

KEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKG--VTIPSQRRYVQYFSKLVCSSVP
|.|  |||.|||| ||||.| .. ||. .| | .|||.||...  ||  |.|   .| |||||||.|||.|. ... 
kadpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkik
0036282 (Phosphotyrosine protein) phosphatases II 28-189 2.3e-46 153.0 In-house 8-168 (174) alignment 
Range on Protein: 28-189
Range on HMM: 8-168/174.0
YDLDLTYINDNIIAMGYPAPdKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNV
..|||.||....||...|..  .| |.......|. ||||.. ..||..|...|...|  ..  ..  .|..||..|... ...|.. |. .|.||....
spldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

VAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKL
|.|||.||.|||||...|||.  |.. |...||... |.|..  ..|..|||.|...||.||
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0038934 (Phosphotyrosine protein) phosphatases II 34-185 2.5e-41 136.8 In-house 15-165 (194) alignment 
Range on Protein: 34-185
Range on HMM: 15-165/194.0
YINDNIIAMGYPAPD----KLEGLFRNRLEDVFKLLEENHAQHYKIYNLC-SERSYDVAKFRG---RVAVYPFDDH-NPPTIELIQRFCSDVDMWLKEDS
.|....||...|...     .|.| |. .||....|.... .......|. .|| ||. .| .   ..  .|| |. ..|..|...||.. || .|.||.
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

SNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKRtkdrkgvtiPSQRRYVQY
..|||||||||.|||||...|||. .  . ||.||.|.. |||         |.. ....|
ggvvaVHCkaGlgRtGtlvaaYLiyrl.gmsaeeAialfrekR.........pgaipnqdy
subfamily_Auxilin_pd Subfamily Auxilin 29-190 2.2e-40 131.1 In-house 8-164 (166) alignment 
Range on Protein: 29-190
Range on HMM: 8-164/166.0
DLDLTYINDNIIAMGYPApDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLcSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVV
|||..||   || | .|| ...|  ..| ..|| . || .| ..|..||| |.|.|. ||...||  . .  .. | .| . . | ....|||.|..|||
dlDisyitsriivmsfPa.egvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvv

AVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRkgvTIPSQRRYVQYFSKLV
 |||| |.  ......|.|||  . .....|.  .  ||.        ||..||..|...|.
vvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladll
0046846 (Phosphotyrosine protein) phosphatases II 22-189 9.4e-40 131.6 In-house 2-171 (176) alignment 
Range on Protein: 22-189
Range on HMM: 2-171/176.0
RYKEKGYDLDLTYINDNIIAMGYP----------APDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSErsydVAKFRGRVAVYPFDDHNPPTIELIQR
|... |.||||.|||.|.|....|           .| || |.... . |. |.|| . ...|..|...|    . |.  .. ..|..||..|..||...
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgiqylhlpwpDhgvpdlellle

FCSDVDMWLKEDssNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKdrKGVTIPSQRRYVQYFSKL
..  .. .|||.  ..|.|||.||.|||||...|||. ..   |..||||.. |.| .  . |. |.|.|....| .|
llefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 26-190 5.2e-37 122.6 In-house 9-160 (172) alignment 
Range on Protein: 26-190
Range on HMM: 9-160/172.0
KGYDLDLTYINDNIIAMGYPapdkleglFRNRLEDVFKLLEENHAQHykIYNLCsER---SYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKE
  ..|||.|| |..||. .|        .|| |.|....| |.. .|  |.||. |.    ... ..  ..  .|..||..|..||...|.. .| .| .
nasyldlyyipdrfiatqgp........lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidellal

DSSNVVAVHCKAGKGRTGTMICAYLVFsgIKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFSKLV
.....|.|||.||.|||||...|||.    . |..||.|.. |||   ...|..|||.|...||.||.
spggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR...pgavqnpsqyrflyyfekll
0039614 (Phosphotyrosine protein) phosphatases II 14-187 2.4e-36 121.1 In-house 53-285 (297) alignment 
Range on Protein: 14-187
Range on HMM: 53-285/297.0
NVVSKKRIRYK--------------EKGYDLDLTYI-----------NDNIIAMGYPAPDK----LEGLFRNRLEDVF----------------------
 ...|.. |||              |.|.|||..||           ....||...| |.     .. ..... . .                       
lpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggt

------KLLEENHAQHYKIYNLCSERsYDVAKFRGRVAVYPFDDHNPP-TIELIQRFCSDVDMWLKED-SSNVVAVHCKAGKGRTGTMICAYLVF----S
      .||.. | ..|....|. .. ..  ..  .. .... ||..| ..||...|.  |. .|.|. ....|.|||.||.|||||.|.|||..    .
ygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlek

GIKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFS
. . ...||.... |.|   ...|..||| |..... 
eggvdvleavkelreqR...pgavqtpsqyrflydal
0037934 (Phosphotyrosine protein) phosphatases II 12-186 6.2e-36 119.6 In-house 5-237 (243) alignment 
Range on Protein: 12-186
Range on HMM: 5-237/243.0
IRNVVSKKRIRYK--------------EKGYDLDLTYINDNIIAMGYPAPD--------KLEGLFRNRLEDVF---------------------------
.. ...... ||.              .  ....|.|. ...||...| |.         .. |.... . .                            
allpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdft

-KLLEENHAQHYKIYNLCSER--SYDVAKFRGRVAVYPFDDHNPPT-IELIQRFCSDVDMWLKE-------DSSNVVAVHCKAGKGRTGTMICAYLVFSG
 .||.|.| ..|....|. |.   .|. ..  ..  .|. ||..|. .| ...|...|  ...|       ||...|.|||.||.|||||.|.|||. . 
vtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmlll

IKKSADEALAWYDEKRTKdrKGVTIPSQRRYVQYF
.. ...||.... |.|    |.|..|||.|.....
lgvdleeavkllreqRpg..kavqtpsqyrflyea
0049260 (Phosphotyrosine protein) phosphatases II 51-189 1.7e-35 117.3 In-house 15-148 (152) alignment 
Range on Protein: 51-189
Range on HMM: 15-148/152.0
EGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFs
.|. .| |.|....| |......  .. ..|. ..  ..  ..  .|..||..|... . .|. ... .|..|....|.|||.||.|||||...|||.  
qgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.

gIKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFSKL
  . |..||.|.. |||    ..|. |.|.|....|.||
.lgvsleeavalvrekR...pgavpnpgqlrflyefekl
0042113 (Phosphotyrosine protein) phosphatases II 15-187 8.2e-34 112.5 In-house 7-239 (245) alignment 
Range on Protein: 15-187
Range on HMM: 7-239/245.0
VVSKKRIRY-------------KEKGYDLDLTYI----------NDNIIAMGYPAPDKLE----GLFRNRLEDVF-------------------------
...|.. ||             .. |.|||..||          ....||...|.|. .|     |...... ..                         
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslty

-----KLLEENHAQHYKIYNLCSER-SYDVAKFRGRVAVYPFDDHNPPT-IELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVF----SG
     .||.|.| ..|....|. ..  .|  ..  ..  .|..||..|. .||...|.. |. .|.|||...|.|||.||.|||||.|.|||..    . 
gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke

IKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFS
 . |..||.... ..|   .. |..||| |..... 
lgvsleeavkelrsqR...pgavqtpsqyrflyeal
0041856 (Phosphotyrosine protein) phosphatases II 27-188 4.4e-32 106.5 In-house 14-168 (182) alignment 
Range on Protein: 27-188
Range on HMM: 14-168/182.0
GYDLDLTYINDNIIAMGYPAPDkLEGLFRNRLEDVFKLLEENHAQHYK-IYNLCsERSYDVAKFRG---RVAVYPFDDHNPPTIELIQRFCSDVDMwlke
 ...||.|||.|......|| .  .   .. |..| . |.  . .... | ||. |. |.  ..     ..  .|..||..|... . .|. .|      
dhsrdldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfieevle....

dSSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFSK
 ....|.|||.||.|||||...|||. .  . |..||.... ..|    ..|..|.| ...|..  
.eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrR...pgmvitpnqyfflqlall
0040438 (Phosphotyrosine protein) phosphatases II 18-186 1.2e-31 105.5 In-house 44-271 (317) alignment 
Range on Protein: 18-186
Range on HMM: 44-271/317.0
KKRIRY-------------KEKGYDLDLTYI----------NDNIIAMGYPAPDKLEG----LFRNRLEDVFKLLEEN----------------------
|.. ||             .  |.|||..||          ....||...| |. .|     ....... .  | |.                       
kdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdf

--------HAQHYKIYNLCSERSYDVAKFRGRVAVYPF-DDHNPP-TIELIQRFCSDVDMWLKeDSSNVVAVHCKAGKGRTGTMICAYLV-----FSGiK
        . .......|. | ..|  ... ..  |.. .||..| ...|...|.. |. .|. |....|.|||.||.|||||.|.|||.       | .
tvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.g

KSADEALAWYDEKRtkdRKGVTIPSQRRYVQYF
 ...||.... |.|   ...|. |.| |.. ..
vdveeavkelreqR...pgavqtpeqyrflyda
0043336 (Phosphotyrosine protein) phosphatases II 18-186 3e-31 104.3 In-house 59-272 (278) alignment 
Range on Protein: 18-186
Range on HMM: 59-272/278.0
KKRIRYKEKGYDLDLTYI----------NDNIIAMGYPAPDkLEGLFRNRLED----------------------------------VFKLLEENHAQHY
 .|.. .  |.|||..||          ....||...| |.  .. |.. . .                                  . .||.|.| ..|
hsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe.tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddy

KIYNLCSER-SYDVAKFRGRVAVYPFDDHNPP-TIELIQRFCSDVDMWLKeDSSNVVAVHCKAGKGRTGTMICAYLVF----SGIKKSADEALAWYDEKR
....|. ..  ..  ..  ..  ... ||. | ...|...|. .|. .|. ||...|.|||.||.|||||.|..||..    .. . ...||.... |.|
tvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR

tkdRKGVTIPSQRRYVQYF
    . |. ||| |.. ..
...pgavqtpsqyrflyea
0045450 (Phosphotyrosine protein) phosphatases II 16-186 1.3e-30 102.7 In-house 54-299 (307) alignment 
Range on Protein: 16-186
Range on HMM: 54-299/307.0
VSKKRIRYKE-------------------------------------KGYDLDLTYI----------------------------------NDNIIAMGY
..|.. |||.                                     .||||....|                                  .....|. .
enkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

PAPdKLEGLFRNrleDVFKLLEENHAQHYKIYNLCSERsYDVAKFRGRVAVYPF---DDHNPP-TIELIQRFCSDVDMWLKED-SSNVVAVHCKAGKGRT
|   . |  ..|   .. .||.|.| ..|....|. .. .|  ..  .| ....    ||. | ..| . .|.  |. .|.|. ....|.|||.||.|||
Pde.geeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRt

GTMICAYLVFSGIK-------KSADEALAWYDEKRtkdRKGVTIPSQRRYVQYF
||.|.|||. ....        ...||.... |.|    ..|. |.| |.....
GtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyea
0044763 (Phosphotyrosine protein) phosphatases II 13-189 6.4e-30 99.5 In-house 4-169 (178) alignment 
Range on Protein: 13-189
Range on HMM: 4-169/178.0
RNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKiynlcsERSYDVAKFRGRVAVYPFDDHNPPT-IELIQR
|..|.   ... | .. .....| ........|..| || | .. .  .  | || .  ..|      .  |.. ..  ..  .|..||..|. .| ...
rtrvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflk......cdpywpeeagiqylhipipDhgvpdllehfle

FCSDVDMWLKeDSSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKRtkdRkGVTIPSQRRYVQYFSKL
|.  .. .|. .. ..|.|||.||.||.||...|||. .  . |..||.... |.|   . .|. |.|.|....| . 
fvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.glsleeaielvrerR...p.ivpnpgqlrqLyefelr
0051082 (Phosphotyrosine protein) phosphatases II 30-187 3.7e-29 96.6 In-house 6-148 (151) alignment 
Range on Protein: 30-187
Range on HMM: 6-148/151.0
LDLTYINDNIIAMGYPAPdkleglfrnrleDVFKLLeeNHAQHYKIYNLCS--ERSYDVAKFRG---RVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDS
....|. ......|.| .            |...||   . ... |.||.|  || |.   ..    .|  .|..|. .|...|.. .. ..  .| ...
infsyvtgglyrsggpla............dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkk

SNVVAVHCKAGKGRTGTMICAYLVFSGikKSADEALAWYDEKRTkdrkGVTIPSQRRYVQYFS
...|.|||.||||||||....||.  |   |..|||..| .||.    ||..|.| ...|.| 
ngpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlfa
0040439 (Phosphotyrosine protein) phosphatases II 19-187 5.5e-29 96.9 In-house 13-242 (249) alignment 
Range on Protein: 19-187
Range on HMM: 13-242/249.0
KRIRYK---------------EKGYD--------LDLTYINDNIIAMGYPAPDkLEGLFRNRLED-----------------------------------
.. ||.               .....        .|..||....||...| |.   . |.. | .                                   
dknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe.tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdf

VFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVY-PFDDHNPP-TIELIQRFCSDVDMWLKED-SSNVVAVHCKAGKGRTGTMICAYLVF----SGIK
. .||.... ..|....|. ...||  ... ..  | .. ||. | ..| . .|.  |. .|.|. ....|.|||.||.|||||.|.|||..       .
tvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelg

KSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFS
 ...||.... ..|   ...|. |.| |..... 
vdleeavkllrsqR...pgavqnpeqyrflyeal
0049772 (Phosphotyrosine protein) phosphatases II 28-186 1.6e-26 89.2 In-house 117-273 (314) alignment 
Range on Protein: 28-186
Range on HMM: 117-273/314.0
YDLDLTYIND---------------------NIIAMGYPapdkleglfrnrledvfklleeNHAQHYKIYNLCsERSYDVAKFRGRVAVY---PFDDHNP
.||.. .|                       ..|..|..                      |.     . .|. |. ||  .| ...  |   |..|...
gdlnvrdivmsrdevladelsrLdaAlgKtpllildgng......................neptaadlellk.eelydpelferlgikylripvpDgsa

PTIELIQRFCSDVDMWlkeDSSNVVAVHCKAGKGRTGT-MICAYLVFSGiKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYF
|..| ...|.  .. .   |  ..|.|||||||||||| ...|||.    . |..|||... .||.   . ..|.....|....
plledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll.gvsleealedvrlkRpinpnpgfieqleqyefil
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 196-335 1.6e-26 84.0 Pfam-A 1-133 (134) alignment 
Range on Protein: 196-335
Range on HMM: 1-133/134.0
YSKVSLNVCEIRFSESSCVQNLGmvECSISVLHDSATENA--KPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKS----PDKIICHFWLNTFFVR
| ...|....|....  .... |  .|...|   . ...   .... |    . .|.|..... ..||.|||..|. .|.     .. |...|.||.|..
ynpkrlelksiilegiPnfktrg..gckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFie

NyspcesdgtvNKYIHTLSKSEIDDVHKDSeHKRFSEEFKISIVFE
.          |....||.|.|.|...||. .|.||..||...|||
k..........nqnvltlpkneLDkalkdk.dkkfsknfkvelvfe
0048076 (Phosphotyrosine protein) phosphatases II 50-188 3.5e-26 87.0 In-house 8-140 (145) alignment 
Range on Protein: 50-188
Range on HMM: 8-140/145.0
LEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRgRVAVYPFDDHNPPTI-ELIQRFCSDVDMWLKEDssNVVAVHCKAGKGRTGTMICAYLV
|.||... | .. .| .  . ... ..||.||... ...   ..  .|..||..|.. ||...|.  .. .|||.  ..|.|||.||.|||||...|||.
lpglylgslptaldlellkdlgittvlnltselellerlgi.qylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylm

FSgIKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFSK
..  . |..|||... ..|   ...|. |.|.|....| .
ll.lgvsleealelvrsqr...pgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 50-188 2.1e-25 84.5 In-house 8-142 (144) alignment 
Range on Protein: 50-188
Range on HMM: 8-142/144.0
LEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRG-RVAVYPFDDHNPPTI-ELIQRFCSDVDMWLKEDssNVVAVHCKAGKGRTGTMICAYL
|.||... | .. .| .  . ... ..||..|. ..  .. | ..  .|..||..|.. ||...|.  .. .|.|.  ..|.|||.||.|||||...|||
lpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaayl

VFSGiKKSADEALAWYDEKRTkdrKGVTIPSQRRYVQYFSK
..   . |..||||.. ..|     .|. |.|.|......|
mkkl.glsleealalvrsrrp...gavpnpgqlrfLleyek
0046845 (Phosphotyrosine protein) phosphatases II 26-186 5.1e-25 83.9 In-house 66-269 (284) alignment 
Range on Protein: 26-186
Range on HMM: 66-269/284.0
KGYDLDLTYINDNIIAMGYPAPD----------------------------KLEGLFRNRLEDVFKL-------LEENHAQHYKIYNLCSERSyDVAKFR
.|||||||||. ..||. .| |.                            .    ...  ..|...       |.|.. ..|....|. ..  .. .. 
dgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytges

GRVAVYPF---DDHNPP-TIELIQRFCSDVDMWLKE-DSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSA-------DEALAWYDEKRtkdRKGVTIPS
 .| .. .    ||. | ..| ...|. .|. .|.. .......|||.||.|||||.|...|... ..|          ||.... |.|      |. ..
rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR...pgmvqtle

QRRYVQYF
| |.| ..
qyrfvyea
0045098 (Phosphotyrosine protein) phosphatases II 25-188 7.6e-25 83.3 In-house 2-269 (278) alignment 
Range on Protein: 25-188
Range on HMM: 2-269/278.0
EKGYDLDLTYINDNIIAMGYPaPDKLEGLFRNRLE-----------------------------------------------------------------
|....|||... ......|.|  . ...|... |.                                                                 
ealasldlllefefllllgip.seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelve

--------------------------DVFKLlEENHAQHYKIYNLCSERSYDVaKFRGRVAVY-PFDDHNPPTIE---LIQRFCSDVDMWLK--------
                          ..  | .. .  .....||..||...  ..  ..  | |..||..|. .    .....  .. .||        
lgrekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefirealkllasllls

----EDSSNVVAVHCKAGKGRTGTMICAYLVFSGI--KKSADEALAWYDEKRtkdRK-GVTIPSQRRYVQYFSK
    .||...|.|||.||.|||||...|||. . .  . ...||.... ..|   .   |....| |.. .|  
slllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR...pglavqnleqyrflyefll
0047943 (Phosphotyrosine protein) phosphatases II 63-185 3.7e-22 74.5 In-house 140-266 (273) alignment 
Range on Protein: 63-185
Range on HMM: 140-266/273.0
KLLEENHAQHYKIYNLCSER-SYDVAKFRGRVAVYPFDDHNPP-TIELIQRFCSDVDMWLKED-SSNVVAVHCKAGKGRTGTMICAYLVF----SGIKKS
.||.|.. ..|....|. .. ...  ..   . .... ||. | ..| . .|. .|. .|... |...|.|||.||.|||||.|...|..     . . .
tllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd

ADEALAWYDEKRTKdrkGVTIPSQRRYVQY
..||.... ..|     .|. |.|.|.. .
vleavkllrsqRpg...mvqtpeqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 63-184 1.3e-20 69.5 In-house 152-279 (288) alignment 
Range on Protein: 63-184
Range on HMM: 152-279/288.0
KLLEENHAQHYKIYNLCSERS--YDVAKFRGRVAVYPF----DDHNPPTIELIQRFCSDVDMWLKeDSSNVVAVHCKAGKGRTGTMICAYLVFSGI-KKS
.||.| . ..|....|. ..   .|  ..  .| .. .    |.. |...||. .|. .|. .|. .....|.|||.||.|||||.|...|... . |. 
tllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeg

ADEALAWYDEKRTKDRKGVTIPSQRRYVQ
  ..|  .   |..    |. |.| |.| 
gvdvleavkrlreqRpgmvqtpeqyrfvy
0036941 (Phosphotyrosine protein) phosphatases II 63-187 1.8e-16 55.8 In-house 140-273 (297) alignment 
Range on Protein: 63-187
Range on HMM: 140-273/297.0
KLLEENH--AQHYKIYNLCSERSYDVAKFRGRVAVYP-FDDHNPPT-IELIQRFCSDVDMWLKED-SSNVVAVHCKAGKGRTGTMICAYLVFSGIK----
.||....   ..|....|. .   .  ... ..  |.  .||..|. .. . .|.  |. .||.  |...| |||.||.||.||.|.|.|... ..    
tllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklk

---KSADEALAWYDEKRTKdrkGVTIPSQRRYVQYFS
    .  ||. .. |.|      |. ..| |.. .. 
eggvdileavkklReqRpg...avqtleqyrflyeal
0050432 (Phosphotyrosine protein) phosphatases II 63-167 1.4e-15 52.9 In-house 171-278 (308) alignment 
Range on Protein: 63-167
Range on HMM: 171-278/308.0
KLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPF--DDHNPPTIELIQRFCSDVDMWLkedSSNVVAVHCKAGKGRTGTMICAYLVFSGIK----KSA
.||.| . ..|....|. . . |   .. ..  |.   |.. || .| . .|.  |. .|   ......|||.|| |||||.|...|... ..     ..
tllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdv

DEALAWYDEKR
 ||...  |.|
feavkklReqR
subfamily_PTPDC1_pd Subfamily PTPDC1 35-188 1.7e-13 45.4 In-house 18-173 (182) alignment 
Range on Protein: 35-188
Range on HMM: 18-173/182.0
INDNIIAMGYPAPDKL------EGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGR-V--AVYPFDDHNPPTIELIQRFCSDVDMWLKEDss
. ..|.|.  |  ...      . .  .... |  | |.    .    .  |  |||  ..  . .    ....|.. ...| |      |.. |.|.  
vtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg..

nVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKRTKdrkGVTIPSQRRYVQYFSK
  ||||| ||.|||| .|..|||..  . .|..|.    .||.|    .   .| . |. |..
.kvavhChaGlGrtGvliacylvyak.rltaekaiklvrskrpk...siqtreqvelvkefal
0048567 (Phosphotyrosine protein) phosphatases II 96-167 5.1e-13 43.7 In-house 43-118 (157) alignment 
Range on Protein: 96-167
Range on HMM: 43-118/157.0
YPFDDHNPPTIELIQRFCSDVDMWLK--EDSSNVVAVHCKAGK---GRTGTMICAYLVFSgIKKSADEALAWYDEKR
 .| |. |... .. ||.  .. .||  |  ....|||||||    |||.|.|..||.    .....||.|..   |
dfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilh.lgftpeeaiaplrivr
subfamily_PRL_pd Subfamily PRL 74-167 1.5e-12 41.8 In-house 37-130 (151) alignment 
Range on Protein: 74-167
Range on HMM: 37-130/151.0
KIYNLCsERSYDVAKFR---GRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKsaDEALAWYDEKR
..   | | .||..|..    .|  ..||| ..|. |..... . . .  ||.....||||| || ||.  ...  |. .|.|.  ..|. .  |||
tvvrvc.eptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGmky..edavefirekr
0051429 (Phosphotyrosine protein) phosphatases II 39-184 2e-12 42.8 In-house 24-218 (272) alignment 
Range on Protein: 39-184
Range on HMM: 24-218/272.0
IIAMGYP---APDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCsersydvakFRGRVAVYPFDDHNPPTIELIQ-------------------------
....|.|    .. .. | ....  .. | .|.  ...| . .             |. ..|. |. .|||....                         
lyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw.........pgirylhlpilddsaptilygalrvtllseellldyilrellltlll

-----------------------RFCSDVDMWL-KedsSNVVAVHCKAGKGRTGTMICAYLVFSGIKKS------------ADEALAWYDEKRtkdRKGV
                         . ..  .| .   .. | |||.|||.||||.....|.  |. ..            ..||...  ..|   .. |
sagearevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqr...pgav

TIPSQRRYVQ
  . |.....
qteeqylfly
subfamily_DSP23_pd Subfamily DSP23 98-166 6.7e-12 40.3 In-house 59-124 (148) alignment 
Range on Protein: 98-166
Range on HMM: 59-124/148.0
FDDHNPPTIELIQRFCSDVDMwlKEDSSNVVAVHCKAGKGRTGTMICAYLVFSgIKKSADEALAWYDEK
 ||. ||..| ...|   |.    |. .. |.|||  |.||||||.  |||    | .| ||.|   ..
iddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvke.rklaaaeaiaevrrl
subfamily_CDC14_pd Subfamily CDC14 56-183 8.7e-12 39.5 In-house 199-316 (328) alignment 
Range on Protein: 56-183
Range on HMM: 199-316/328.0
NRLEDVFKLLEENHAQhyKIYNLCsERSYDVAKFRGRV---AVYPFDDHNPPTIELIQRFCSDVDMWlkedsSNVVAVHCKAGKGRTGTMICAYLVFSgI
.  | ...   .|. .  ..  |  .. ||  ||           | |   |. .....| . ..       .  .||||||| |||||.| .||.    
haPeklleyfrknnvt..tvvrLn.kklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkh.y

KKSADEALAWYdekRTkDRKGVTIPSQRRYV
. .| ||.||    |   | |. |  |....
rftaaeaiawl...ri.crPGsvigpqqkfl
PTPc_DSPc_SM00012 99-167 1.6e-11 39.7 In-house 11-83 (105) alignment 
Range on Protein: 99-167
Range on HMM: 11-83/105.0
DDHNPP-TIELIQRFCSDVDMWLKEDS-SNVVAVHCKAGKGRTGTMICAYLVFSGIKKSA--DEALAWYDEKR
 ||. | . . | ... .|. . .. . |. | |||.|| |||||....... . ..|.   .. . .  | |
pdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelr
subfamily_DSP11_pd Subfamily DSP11 81-168 4.2e-11 37.0 In-house 67-158 (178) alignment 
Range on Protein: 81-168
Range on HMM: 67-158/178.0
ERSYDVAKFRGRVAVY---PFDDHNPPTIELIQRFCSDVDMWL--KEDSSNVVAVHCKAGKGRTGTMICAYLVfSGIKKSADEALAWYDEKRT
.| |.  ..  .   |       |. |. ||...|.. |. .|  ..|. ....|||  |  ||| .|| ||. .    ....|.  ..| | 
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCryli.dvegyepedaieafeearG
subfamily_RNGTT_pd Subfamily RNGTT 102-169 8.4e-11 35.9 In-house 90-156 (189) alignment 
Range on Protein: 102-169
Range on HMM: 90-156/189.0
NPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVfSGIKKSADEALAWYDEKRTK
. |. | ...| . |. . |. ...|..|||. |  ||| .|..|||    . |...|.| . . | .
eaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLv.ekedwsveaavalFakaRpp
subfamily_PTPMT1_pd Subfamily PTPMT1 95-171 2e-09 32.1 In-house 78-152 (171) alignment 
Range on Protein: 95-171
Range on HMM: 78-152/171.0
VYPFDDHN-PPTIELIQRFCSDVDMWLKEdsSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKRTKDR
 ..  |.   |..| ...    ..   ..   . | ||||||.||..|.. .||. .  | | .|||    .|| . |
qlatvDfteapdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkke.klspeeAlkalkkkRkiir
DSPc Dual specificity phosphatase, catalytic domain 122-167 3.1e-08 28.5 Pfam-A 70-114 (133) alignment 
Range on Protein: 122-167
Range on HMM: 70-114/133.0
EDSSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKR
|.. . |.|||.||  |..|.|.|||  .  . |..||..   |.|
eqkgkkvlVHCqaGisRSatliiaYlmktk.nlslneAyefvkerr
DSPc Dual specificity phosphatase, catalytic domain 122-167 3.1e-08 28.5 In-house 70-114 (133) alignment 
Range on Protein: 122-167
Range on HMM: 70-114/133.0
EDSSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKR
|.. . |.|||.||  |..|.|.|||  .  . |..||..   |.|
eqkgkkvlVHCqaGisRSatliiaYlmktk.nlslneAyefvkerr
PTPc_motif_SM00404 110-167 1.1e-07 26.8 In-house 70-121 (140) alignment 
Range on Protein: 110-167
Range on HMM: 70-121/140.0
QRFCSDVdmwlkEDSSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKR
 .| ...     |..   | |||.||  |..|.|.|||  .  . |..||.  . |.|
ldfiena.....ekkggkvlVHCqaGvSRSatliiaYlmryr.qlslaeayefvkerR
subfamily_PTPN13_pd Subfamily PTPN13 75-161 1.7e-07 25.8 In-house 157-238 (273) alignment 
Range on Protein: 75-161
Range on HMM: 157-238/273.0
IYNLCSERSYDVAKFRgrVAVYPfdDHNPP-TIELIQRFCSDVDMwLKEdSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALA
. .. |..| .||...   . .|  ||. | . . . .| . |   |.. ..  ..||| || ||.||.|. . |.  |..  .  . 
vkdsesgesrevahln..fvkwP..dhgvPssaaellqfvaevrr.lqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 63-156 6.5e-07 23.7 In-house 151-247 (319) alignment 
Range on Protein: 63-156
Range on HMM: 151-247/319.0
KLLEENHAQHYKIYNLCSER-SYDVAKfRgRVAVYPF---DDHN-PPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSA
.|.||.. ..| | .|. .. | .|   | .|  . .    ||. | .  ..  .  ..    .. .|  . ||| || ||||| |    ..  .|. .
tleeeeeledyiirklklnkkssevet.R.evkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeeg
DSPc_SM00195 66-216 7.4e-07 24.1 In-house 134-247 (263) alignment 
Range on Protein: 66-216
Range on HMM: 134-247/263.0
EENHAQ-HYKIYNLCSERSYD-VAKFRGRVAVYPFDDHNPP-TIELIQRFCSDVDMWLKEDsSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADealaw
|... . ......|  .   .  ...   . .    ||. | . . . .. . |. . ..  |. . |||.|| |||||.... .. | ...  .     
evekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekk.....

ydekrtkdrkgvtipsqrryvqyfsklvcssvpySKVSLNVCEIRFSESSCVQN
                                   ...  |.|.| .  ..||.
..................................vdifeivkelRkqRpgmvqt
PTPc_SM00194 66-216 7.4e-07 24.1 In-house 134-247 (263) alignment 
Range on Protein: 66-216
Range on HMM: 134-247/263.0
EENHAQ-HYKIYNLCSERSYD-VAKFRGRVAVYPFDDHNPP-TIELIQRFCSDVDMWLKEDsSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADealaw
|... . ......|  .   .  ...   . .    ||. | . . . .. . |. . ..  |. . |||.|| |||||.... .. | ...  .     
evekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekk.....

ydekrtkdrkgvtipsqrryvqyfsklvcssvpySKVSLNVCEIRFSESSCVQN
                                   ...  |.|.| .  ..||.
..................................vdifeivkelRkqRpgmvqt
Y_phosphatase Protein-tyrosine phosphatase 100-154 1.2e-06 23.5 Pfam-A 145-199 (235) alignment 
Range on Protein: 100-154
Range on HMM: 145-199/235.0
DHN-PPTIELIQRFCSDVDMWLkEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKK
||. | . . . ... .|  .  |..|. | |||.|| |||||.... .... ...
dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea
Y_phosphatase Protein-tyrosine phosphatase 100-154 1.2e-06 23.5 In-house 145-199 (235) alignment 
Range on Protein: 100-154
Range on HMM: 145-199/235.0
DHN-PPTIELIQRFCSDVDMWLkEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKK
||. | . . . ... .|  .  |..|. | |||.|| |||||.... .... ...
dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea
subfamily_PTPN6_pd Subfamily PTPN6 64-155 2e-06 22.1 In-house 160-257 (306) alignment 
Range on Protein: 64-155
Range on HMM: 160-257/306.0
LLEENHAQHYKIYNLCSERSYDVAKFRgRVAVYPF---DDHN-PPTIELIQRFCSDVDMWLKEDS---SNVVAVHCKAGKGRTGTMICAYLVFSGIKKS
 ..|.....|.. .|  ..  .  . | .|  | |    ||. |   . .  | .||..  .| .   .  . ||| || |||||.|   .. . |.|.
nvseksladYilRelsvskkkkkkeer.evfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekk
subfamily_PTPRB_pd Subfamily PTPRB 65-153 3.2e-06 21.4 In-house 157-246 (293) alignment 
Range on Protein: 65-153
Range on HMM: 157-246/293.0
LEENHAQHYKIYNLCSERSYDVAKFRgRVAVYPFDDHN-PPTIELIQRFCSDVDMWL-KEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIK
..|.. ... | .|  |.. .  | | .     . ||. | . . . .|.  |. .. |. |.. . ||| || ||||| |.   ... |.
vaeeeledwvirelkiekekeerkvr.qyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaie
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 100-153 3.9e-06 21.2 In-house 187-241 (318) alignment 
Range on Protein: 100-153
Range on HMM: 187-241/318.0
DHNPPT--IELIqRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIK
|.. |.   .|.  .  .|. . .. . ....||| || ||||. |    .   ||
degvpesgasll.dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerik
subfamily_PTPN12_pd Subfamily PTPN12 100-157 4.6e-06 20.7 In-house 182-239 (290) alignment 
Range on Protein: 100-157
Range on HMM: 182-239/290.0
DH-NPPTIELIQRFCSDVDMWLKeDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSAD
||  | ... . .. ..|    . .... ..||| || |||||.|   .| . .|.   
DhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaeki
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 99-154 6.9e-06 20.3 In-house 173-230 (274) alignment 
Range on Protein: 99-154
Range on HMM: 173-230/274.0
DDHNPPTIELIQRFCSDVDMWLKEDSSN--VVAVHCKAGKGRTGTMICAYLVFSGIKK
| . |  .. . ... .|.   .|.. .   | ||| || ||||  | . .    ...
dhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre