Gene Pten in Drosophila melanogaster

Synonym: CG5671, DPTEN, Dmel\CG5671, PTEN, PTEN3, dPTEN, dPten, dpten, pten, Dmel_CG5671, Pten

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP035_AA protein Get Run
DmelP035_AA_11-216 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTEN_pd Subfamily PTEN 12-193 6.3e-87 285.3 In-house 2-182 (184) alignment
Range on Protein: 12-193
Range on HMM: 2-182/184.0
IRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPApDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQR
.|..||||..|.||.|.||||.||..||||||||| .|||.|.||.||||.|.||..|..|||||||.|||.|| .||.||||||||||||||..||...
lrkivskkkkrfkedgldLDlsyiteniiamgyPa.eklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplellee

FCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKLVCSS
...|...||.||..|||.|||||||||||..|.|||. |.. ..|.|||....|.|||..||||||||||||.|..||. ..
ivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee

subfamily_VSP_pd Subfamily VSP 9-190 1.1e-61 202.4 In-house 13-198 (212) alignment
Range on Protein: 9-190
Range on HMM: 13-198/212.0
SNVIRNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKlEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIEL
 ...|..||. . ||.. |.||||||. . |||| .|.  | . |.|| ...| ..|.. | .|||..||||||.|| . |. ||     |||| |..| 
ekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGk.qslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpklee

IQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDR-----KGVTIPSQRRYVQYFSKLV
.  |. .|  ||..| .||.|.||| |||||||..||.|. |.| ..|.|.| .. |.||.       .||  |||.|||.|. ...
llvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvk

PTEN_1 19-191 2.1e-50 166.3 In-house 9-193 (196) alignment
Range on Protein: 19-191
Range on HMM: 9-193/196.0
KRIRYKEKGYDLDLTYINDNIIAMGYPAPDK-----LEGLFRNRLEDVFKLLEENHAQH-YKIYNLCSERS-----YDVAK-FRGRVA--VYPFDDHNPP
.  .. . . .||||||.. |||||..  ..      |||.|..|.|| ..|....... . ..||..|.      ||  . |...|    .|..||..|
skknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgap

TIELIQRFCSDVDMWLKEDS-SNVVAVHCKAGKGRTGTMICAYLVFSGIkKSADEALAWYDEKRTKDRKGvtIPSQRRYVQYFSKLVC
... ....| ... ||..|.  |||.||||||.||.||...|||...|   .|||||... |||.. ..   .|||.|...||..|  
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaella

subfamily_Tensin_pd Subfamily Tensin 21-195 3.7e-47 153.3 In-house 2-176 (189) alignment
Range on Protein: 21-195
Range on HMM: 2-176/189.0
IRYKEKGYDLDLTYINDNIIAMGYPApDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLcSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWL
 || |. .||||||| . |||. .|| . ||  .|. |.|| |||...| ..| ..|| ||..||. |.  .|  . . |.  |..| .   | ..| ||
vryveekvdldltyiteriialsfpa.egleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWl

KEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKG--VTIPSQRRYVQYFSKLVCSSVP
|.|  |||.|||| ||||.| .. ||. .| | .|||.||...  ||  |.|   .| |||||||.|||.|. ... 
kadpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkik

0036282 (Phosphotyrosine protein) phosphatases II 28-189 2.3e-46 153.0 In-house 8-168 (174) alignment
Range on Protein: 28-189
Range on HMM: 8-168/174.0
YDLDLTYINDNIIAMGYPAPdKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNV
..|||.||....||...|..  .| |.......|. ||||.. ..||..|...|...|  ..  ..  .|..||..|... ...|.. |. .|.||....
spldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

VAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYFSKL
|.|||.||.|||||...|||.  |.. |...||... |.|..  ..|..|||.|...||.||
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl

0038934 (Phosphotyrosine protein) phosphatases II 34-185 2.5e-41 136.8 In-house 15-165 (194) alignment
Range on Protein: 34-185
Range on HMM: 15-165/194.0
YINDNIIAMGYPAPD----KLEGLFRNRLEDVFKLLEENHAQHYKIYNLC-SERSYDVAKFRG---RVAVYPFDDH-NPPTIELIQRFCSDVDMWLKEDS
.|....||...|...     .|.| |. .||....|.... .......|. .|| ||. .| .   ..  .|| |. ..|..|...||.. || .|.||.
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

SNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKRtkdrkgvtiPSQRRYVQY
..|||||||||.|||||...|||. .  . ||.||.|.. |||         |.. ....|
ggvvaVHCkaGlgRtGtlvaaYLiyrl.gmsaeeAialfrekR.........pgaipnqdy

subfamily_Auxilin_pd Subfamily Auxilin 29-190 2.2e-40 131.1 In-house 8-164 (166) alignment
Range on Protein: 29-190
Range on HMM: 8-164/166.0
DLDLTYINDNIIAMGYPApDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLcSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVV
|||..||   || | .|| ...|  ..| ..|| . || .| ..|..||| |.|.|. ||...||  . .  .. | .| . . | ....|||.|..|||
dlDisyitsriivmsfPa.egvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvv

AVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKDRkgvTIPSQRRYVQYFSKLV
 |||| |.  ......|.|||  . .....|.  .  ||.        ||..||..|...|.
vvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladll

0046846 (Phosphotyrosine protein) phosphatases II 22-189 9.4e-40 131.6 In-house 2-171 (176) alignment
Range on Protein: 22-189
Range on HMM: 2-171/176.0
RYKEKGYDLDLTYINDNIIAMGYP----------APDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCSErsydVAKFRGRVAVYPFDDHNPPTIELIQR
|... |.||||.|||.|.|....|           .| || |.... . |. |.|| . ...|..|...|    . |.  .. ..|..||..|..||...
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgiqylhlpwpDhgvpdlellle

FCSDVDMWLKEDssNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALAWYDEKRTKdrKGVTIPSQRRYVQYFSKL
..  .. .|||.  ..|.|||.||.|||||...|||. ..   |..||||.. |.| .  . |. |.|.|....| .|
llefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefell

0043147 (Phosphotyrosine protein) phosphatases II 26-190 5.2e-37 122.6 In-house 9-160 (172) alignment
Range on Protein: 26-190
Range on HMM: 9-160/172.0
KGYDLDLTYINDNIIAMGYPapdkleglFRNRLEDVFKLLEENHAQHykIYNLCsER---SYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKE
  ..|||.|| |..||. .|        .|| |.|....| |.. .|  |.||. |.    ... ..  ..  .|..||..|..||...|.. .| .| .
nasyldlyyipdrfiatqgp........lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidellal

DSSNVVAVHCKAGKGRTGTMICAYLVFsgIKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFSKLV
.....|.|||.||.|||||...|||.    . |..||.|.. |||   ...|..|||.|...||.||.
spggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR...pgavqnpsqyrflyyfekll

0039614 (Phosphotyrosine protein) phosphatases II 14-187 2.4e-36 121.1 In-house 53-285 (297) alignment
Range on Protein: 14-187
Range on HMM: 53-285/297.0
NVVSKKRIRYK--------------EKGYDLDLTYI-----------NDNIIAMGYPAPDK----LEGLFRNRLEDVF----------------------
 ...|.. |||              |.|.|||..||           ....||...| |.     .. ..... . .                       
lpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggt

------KLLEENHAQHYKIYNLCSERsYDVAKFRGRVAVYPFDDHNPP-TIELIQRFCSDVDMWLKED-SSNVVAVHCKAGKGRTGTMICAYLVF----S
      .||.. | ..|....|. .. ..  ..  .. .... ||..| ..||...|.  |. .|.|. ....|.|||.||.|||||.|.|||..    .
ygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlek

GIKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFS
. . ...||.... |.|   ...|..||| |..... 
eggvdvleavkelreqR...pgavqtpsqyrflydal

0037934 (Phosphotyrosine protein) phosphatases II 12-186 6.2e-36 119.6 In-house 5-237 (243) alignment
Range on Protein: 12-186
Range on HMM: 5-237/243.0
IRNVVSKKRIRYK--------------EKGYDLDLTYINDNIIAMGYPAPD--------KLEGLFRNRLEDVF---------------------------
.. ...... ||.              .  ....|.|. ...||...| |.         .. |.... . .                            
allpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdft

-KLLEENHAQHYKIYNLCSER--SYDVAKFRGRVAVYPFDDHNPPT-IELIQRFCSDVDMWLKE-------DSSNVVAVHCKAGKGRTGTMICAYLVFSG
 .||.|.| ..|....|. |.   .|. ..  ..  .|. ||..|. .| ...|...|  ...|       ||...|.|||.||.|||||.|.|||. . 
vtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmlll

IKKSADEALAWYDEKRTKdrKGVTIPSQRRYVQYF
.. ...||.... |.|    |.|..|||.|.....
lgvdleeavkllreqRpg..kavqtpsqyrflyea

0049260 (Phosphotyrosine protein) phosphatases II 51-189 1.7e-35 117.3 In-house 15-148 (152) alignment
Range on Protein: 51-189
Range on HMM: 15-148/152.0
EGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFs
.|. .| |.|....| |......  .. ..|. ..  ..  ..  .|..||..|... . .|. ... .|..|....|.|||.||.|||||...|||.  
qgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.

gIKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFSKL
  . |..||.|.. |||    ..|. |.|.|....|.||
.lgvsleeavalvrekR...pgavpnpgqlrflyefekl

0042113 (Phosphotyrosine protein) phosphatases II 15-187 8.2e-34 112.5 In-house 7-239 (245) alignment
Range on Protein: 15-187
Range on HMM: 7-239/245.0
VVSKKRIRY-------------KEKGYDLDLTYI----------NDNIIAMGYPAPDKLE----GLFRNRLEDVF-------------------------
...|.. ||             .. |.|||..||          ....||...|.|. .|     |...... ..                         
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslty

-----KLLEENHAQHYKIYNLCSER-SYDVAKFRGRVAVYPFDDHNPPT-IELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVF----SG
     .||.|.| ..|....|. ..  .|  ..  ..  .|..||..|. .||...|.. |. .|.|||...|.|||.||.|||||.|.|||..    . 
gdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke

IKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFS
 . |..||.... ..|   .. |..||| |..... 
lgvsleeavkelrsqR...pgavqtpsqyrflyeal

0041856 (Phosphotyrosine protein) phosphatases II 27-188 4.4e-32 106.5 In-house 14-168 (182) alignment
Range on Protein: 27-188
Range on HMM: 14-168/182.0
GYDLDLTYINDNIIAMGYPAPDkLEGLFRNRLEDVFKLLEENHAQHYK-IYNLCsERSYDVAKFRG---RVAVYPFDDHNPPTIELIQRFCSDVDMwlke
 ...||.|||.|......|| .  .   .. |..| . |.  . .... | ||. |. |.  ..     ..  .|..||..|... . .|. .|      
dhsrdldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfieevle....

dSSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFSK
 ....|.|||.||.|||||...|||. .  . |..||.... ..|    ..|..|.| ...|..  
.eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrR...pgmvitpnqyfflqlall

0040438 (Phosphotyrosine protein) phosphatases II 18-186 1.2e-31 105.5 In-house 44-271 (317) alignment
Range on Protein: 18-186
Range on HMM: 44-271/317.0
KKRIRY-------------KEKGYDLDLTYI----------NDNIIAMGYPAPDKLEG----LFRNRLEDVFKLLEEN----------------------
|.. ||             .  |.|||..||          ....||...| |. .|     ....... .  | |.                       
kdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdf

--------HAQHYKIYNLCSERSYDVAKFRGRVAVYPF-DDHNPP-TIELIQRFCSDVDMWLKeDSSNVVAVHCKAGKGRTGTMICAYLV-----FSGiK
        . .......|. | ..|  ... ..  |.. .||..| ...|...|.. |. .|. |....|.|||.||.|||||.|.|||.       | .
tvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.g

KSADEALAWYDEKRtkdRKGVTIPSQRRYVQYF
 ...||.... |.|   ...|. |.| |.. ..
vdveeavkelreqR...pgavqtpeqyrflyda

0043336 (Phosphotyrosine protein) phosphatases II 18-186 3e-31 104.3 In-house 59-272 (278) alignment
Range on Protein: 18-186
Range on HMM: 59-272/278.0
KKRIRYKEKGYDLDLTYI----------NDNIIAMGYPAPDkLEGLFRNRLED----------------------------------VFKLLEENHAQHY
 .|.. .  |.|||..||          ....||...| |.  .. |.. . .                                  . .||.|.| ..|
hsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe.tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddy

KIYNLCSER-SYDVAKFRGRVAVYPFDDHNPP-TIELIQRFCSDVDMWLKeDSSNVVAVHCKAGKGRTGTMICAYLVF----SGIKKSADEALAWYDEKR
....|. ..  ..  ..  ..  ... ||. | ...|...|. .|. .|. ||...|.|||.||.|||||.|..||..    .. . ...||.... |.|
tvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR

tkdRKGVTIPSQRRYVQYF
    . |. ||| |.. ..
...pgavqtpsqyrflyea

0045450 (Phosphotyrosine protein) phosphatases II 16-186 1.3e-30 102.7 In-house 54-299 (307) alignment
Range on Protein: 16-186
Range on HMM: 54-299/307.0
VSKKRIRYKE-------------------------------------KGYDLDLTYI----------------------------------NDNIIAMGY
..|.. |||.                                     .||||....|                                  .....|. .
enkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

PAPdKLEGLFRNrleDVFKLLEENHAQHYKIYNLCSERsYDVAKFRGRVAVYPF---DDHNPP-TIELIQRFCSDVDMWLKED-SSNVVAVHCKAGKGRT
|   . |  ..|   .. .||.|.| ..|....|. .. .|  ..  .| ....    ||. | ..| . .|.  |. .|.|. ....|.|||.||.|||
Pde.geeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRt

GTMICAYLVFSGIK-------KSADEALAWYDEKRtkdRKGVTIPSQRRYVQYF
||.|.|||. ....        ...||.... |.|    ..|. |.| |.....
GtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyea

0044763 (Phosphotyrosine protein) phosphatases II 13-189 6.4e-30 99.5 In-house 4-169 (178) alignment
Range on Protein: 13-189
Range on HMM: 4-169/178.0
RNVVSKKRIRYKEKGYDLDLTYINDNIIAMGYPAPDKLEGLFRNRLEDVFKLLEENHAQHYKiynlcsERSYDVAKFRGRVAVYPFDDHNPPT-IELIQR
|..|.   ... | .. .....| ........|..| || | .. .  .  | || .  ..|      .  |.. ..  ..  .|..||..|. .| ...
rtrvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflk......cdpywpeeagiqylhipipDhgvpdllehfle

FCSDVDMWLKeDSSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKRtkdRkGVTIPSQRRYVQYFSKL
|.  .. .|. .. ..|.|||.||.||.||...|||. .  . |..||.... |.|   . .|. |.|.|....| . 
fvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl.glsleeaielvrerR...p.ivpnpgqlrqLyefelr

0051082 (Phosphotyrosine protein) phosphatases II 30-187 3.7e-29 96.6 In-house 6-148 (151) alignment
Range on Protein: 30-187
Range on HMM: 6-148/151.0
LDLTYINDNIIAMGYPAPdkleglfrnrleDVFKLLeeNHAQHYKIYNLCS--ERSYDVAKFRG---RVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDS
....|. ......|.| .            |...||   . ... |.||.|  || |.   ..    .|  .|..|. .|...|.. .. ..  .| ...
infsyvtgglyrsggpla............dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkk

SNVVAVHCKAGKGRTGTMICAYLVFSGikKSADEALAWYDEKRTkdrkGVTIPSQRRYVQYFS
...|.|||.||||||||....||.  |   |..|||..| .||.    ||..|.| ...|.| 
ngpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlfa

0040439 (Phosphotyrosine protein) phosphatases II 19-187 5.5e-29 96.9 In-house 13-242 (249) alignment
Range on Protein: 19-187
Range on HMM: 13-242/249.0
KRIRYK---------------EKGYD--------LDLTYINDNIIAMGYPAPDkLEGLFRNRLED-----------------------------------
.. ||.               .....        .|..||....||...| |.   . |.. | .                                   
dknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe.tvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdf

VFKLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVY-PFDDHNPP-TIELIQRFCSDVDMWLKED-SSNVVAVHCKAGKGRTGTMICAYLVF----SGIK
. .||.... ..|....|. ...||  ... ..  | .. ||. | ..| . .|.  |. .|.|. ....|.|||.||.|||||.|.|||..       .
tvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelg

KSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFS
 ...||.... ..|   ...|. |.| |..... 
vdleeavkllrsqR...pgavqnpeqyrflyeal

0049772 (Phosphotyrosine protein) phosphatases II 28-186 1.6e-26 89.2 In-house 117-273 (314) alignment
Range on Protein: 28-186
Range on HMM: 117-273/314.0
YDLDLTYIND---------------------NIIAMGYPapdkleglfrnrledvfklleeNHAQHYKIYNLCsERSYDVAKFRGRVAVY---PFDDHNP
.||.. .|                       ..|..|..                      |.     . .|. |. ||  .| ...  |   |..|...
gdlnvrdivmsrdevladelsrLdaAlgKtpllildgng......................neptaadlellk.eelydpelferlgikylripvpDgsa

PTIELIQRFCSDVDMWlkeDSSNVVAVHCKAGKGRTGT-MICAYLVFSGiKKSADEALAWYDEKRTKDRKGVTIPSQRRYVQYF
|..| ...|.  .. .   |  ..|.|||||||||||| ...|||.    . |..|||... .||.   . ..|.....|....
plledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll.gvsleealedvrlkRpinpnpgfieqleqyefil

PTEN_C2 C2 domain of PTEN tumour-suppressor protein 196-335 1.6e-26 84.0 Pfam-A 1-133 (134) alignment
Range on Protein: 196-335
Range on HMM: 1-133/134.0
YSKVSLNVCEIRFSESSCVQNLGmvECSISVLHDSATENA--KPDRLKTLPIDFQKSFVLTIKPSIPVSGDVKFELTKKS----PDKIICHFWLNTFFVR
| ...|....|....  .... |  .|...|   . ...   .... |    . .|.|..... ..||.|||..|. .|.     .. |...|.||.|..
ynpkrlelksiilegiPnfktrg..gckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFie

NyspcesdgtvNKYIHTLSKSEIDDVHKDSeHKRFSEEFKISIVFE
.          |....||.|.|.|...||. .|.||..||...|||
k..........nqnvltlpkneLDkalkdk.dkkfsknfkvelvfe

0048076 (Phosphotyrosine protein) phosphatases II 50-188 3.5e-26 87.0 In-house 8-140 (145) alignment
Range on Protein: 50-188
Range on HMM: 8-140/145.0
LEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRgRVAVYPFDDHNPPTI-ELIQRFCSDVDMWLKEDssNVVAVHCKAGKGRTGTMICAYLV
|.||... | .. .| .  . ... ..||.||... ...   ..  .|..||..|.. ||...|.  .. .|||.  ..|.|||.||.|||||...|||.
lpglylgslptaldlellkdlgittvlnltselellerlgi.qylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylm

FSgIKKSADEALAWYDEKRtkdRKGVTIPSQRRYVQYFSK
..  . |..|||... ..|   ...|. |.|.|....| .
ll.lgvsleealelvrsqr...pgavpnpgqlrflyefel

0048179 (Phosphotyrosine protein) phosphatases II 50-188 2.1e-25 84.5 In-house 8-142 (144) alignment
Range on Protein: 50-188
Range on HMM: 8-142/144.0
LEGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRG-RVAVYPFDDHNPPTI-ELIQRFCSDVDMWLKEDssNVVAVHCKAGKGRTGTMICAYL
|.||... | .. .| .  . ... ..||..|. ..  .. | ..  .|..||..|.. ||...|.  .. .|.|.  ..|.|||.||.|||||...|||
lpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaayl

VFSGiKKSADEALAWYDEKRTkdrKGVTIPSQRRYVQYFSK
..   . |..||||.. ..|     .|. |.|.|......|
mkkl.glsleealalvrsrrp...gavpnpgqlrfLleyek

0046845 (Phosphotyrosine protein) phosphatases II 26-186 5.1e-25 83.9 In-house 66-269 (284) alignment
Range on Protein: 26-186
Range on HMM: 66-269/284.0
KGYDLDLTYINDNIIAMGYPAPD----------------------------KLEGLFRNRLEDVFKL-------LEENHAQHYKIYNLCSERSyDVAKFR
.|||||||||. ..||. .| |.                            .    ...  ..|...       |.|.. ..|....|. ..  .. .. 
dgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytges

GRVAVYPF---DDHNPP-TIELIQRFCSDVDMWLKE-DSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSA-------DEALAWYDEKRtkdRKGVTIPS
 .| .. .    ||. | ..| ...|. .|. .|.. .......|||.||.|||||.|...|... ..|          ||.... |.|      |. ..
rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR...pgmvqtle

QRRYVQYF
| |.| ..
qyrfvyea

0045098 (Phosphotyrosine protein) phosphatases II 25-188 7.6e-25 83.3 In-house 2-269 (278) alignment
Range on Protein: 25-188
Range on HMM: 2-269/278.0
EKGYDLDLTYINDNIIAMGYPaPDKLEGLFRNRLE-----------------------------------------------------------------
|....|||... ......|.|  . ...|... |.                                                                 
ealasldlllefefllllgip.seitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelve

--------------------------DVFKLlEENHAQHYKIYNLCSERSYDVaKFRGRVAVY-PFDDHNPPTIE---LIQRFCSDVDMWLK--------
                          ..  | .. .  .....||..||...  ..  ..  | |..||..|. .    .....  .. .||        
lgrekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefirealkllasllls

----EDSSNVVAVHCKAGKGRTGTMICAYLVFSGI--KKSADEALAWYDEKRtkdRK-GVTIPSQRRYVQYFSK
    .||...|.|||.||.|||||...|||. . .  . ...||.... ..|   .   |....| |.. .|  
slllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR...pglavqnleqyrflyefll

0047943 (Phosphotyrosine protein) phosphatases II 63-185 3.7e-22 74.5 In-house 140-266 (273) alignment
Range on Protein: 63-185
Range on HMM: 140-266/273.0
KLLEENHAQHYKIYNLCSER-SYDVAKFRGRVAVYPFDDHNPP-TIELIQRFCSDVDMWLKED-SSNVVAVHCKAGKGRTGTMICAYLVF----SGIKKS
.||.|.. ..|....|. .. ...  ..   . .... ||. | ..| . .|. .|. .|... |...|.|||.||.|||||.|...|..     . . .
tllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd

ADEALAWYDEKRTKdrkGVTIPSQRRYVQY
..||.... ..|     .|. |.|.|.. .
vleavkllrsqRpg...mvqtpeqyrflye

0051299 (Phosphotyrosine protein) phosphatases II 63-184 1.3e-20 69.5 In-house 152-279 (288) alignment
Range on Protein: 63-184
Range on HMM: 152-279/288.0
KLLEENHAQHYKIYNLCSERS--YDVAKFRGRVAVYPF----DDHNPPTIELIQRFCSDVDMWLKeDSSNVVAVHCKAGKGRTGTMICAYLVFSGI-KKS
.||.| . ..|....|. ..   .|  ..  .| .. .    |.. |...||. .|. .|. .|. .....|.|||.||.|||||.|...|... . |. 
tllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeg

ADEALAWYDEKRTKDRKGVTIPSQRRYVQ
  ..|  .   |..    |. |.| |.| 
gvdvleavkrlreqRpgmvqtpeqyrfvy

0036941 (Phosphotyrosine protein) phosphatases II 63-187 1.8e-16 55.8 In-house 140-273 (297) alignment
Range on Protein: 63-187
Range on HMM: 140-273/297.0
KLLEENH--AQHYKIYNLCSERSYDVAKFRGRVAVYP-FDDHNPPT-IELIQRFCSDVDMWLKED-SSNVVAVHCKAGKGRTGTMICAYLVFSGIK----
.||....   ..|....|. .   .  ... ..  |.  .||..|. .. . .|.  |. .||.  |...| |||.||.||.||.|.|.|... ..    
tllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklk

---KSADEALAWYDEKRTKdrkGVTIPSQRRYVQYFS
    .  ||. .. |.|      |. ..| |.. .. 
eggvdileavkklReqRpg...avqtleqyrflyeal

0050432 (Phosphotyrosine protein) phosphatases II 63-167 1.4e-15 52.9 In-house 171-278 (308) alignment
Range on Protein: 63-167
Range on HMM: 171-278/308.0
KLLEENHAQHYKIYNLCSERSYDVAKFRGRVAVYPF--DDHNPPTIELIQRFCSDVDMWLkedSSNVVAVHCKAGKGRTGTMICAYLVFSGIK----KSA
.||.| . ..|....|. . . |   .. ..  |.   |.. || .| . .|.  |. .|   ......|||.|| |||||.|...|... ..     ..
tllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdv

DEALAWYDEKR
 ||...  |.|
feavkklReqR

subfamily_PTPDC1_pd Subfamily PTPDC1 35-188 1.7e-13 45.4 In-house 18-173 (182) alignment
Range on Protein: 35-188
Range on HMM: 18-173/182.0
INDNIIAMGYPAPDKL------EGLFRNRLEDVFKLLEENHAQHYKIYNLCSERSYDVAKFRGR-V--AVYPFDDHNPPTIELIQRFCSDVDMWLKEDss
. ..|.|.  |  ...      . .  .... |  | |.    .    .  |  |||  ..  . .    ....|.. ...| |      |.. |.|.  
vtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg..

nVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKRTKdrkGVTIPSQRRYVQYFSK
  ||||| ||.|||| .|..|||..  . .|..|.    .||.|    .   .| . |. |..
.kvavhChaGlGrtGvliacylvyak.rltaekaiklvrskrpk...siqtreqvelvkefal

0048567 (Phosphotyrosine protein) phosphatases II 96-167 5.1e-13 43.7 In-house 43-118 (157) alignment
Range on Protein: 96-167
Range on HMM: 43-118/157.0
YPFDDHNPPTIELIQRFCSDVDMWLK--EDSSNVVAVHCKAGK---GRTGTMICAYLVFSgIKKSADEALAWYDEKR
 .| |. |... .. ||.  .. .||  |  ....|||||||    |||.|.|..||.    .....||.|..   |
dfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilh.lgftpeeaiaplrivr

subfamily_PRL_pd Subfamily PRL 74-167 1.5e-12 41.8 In-house 37-130 (151) alignment
Range on Protein: 74-167
Range on HMM: 37-130/151.0
KIYNLCsERSYDVAKFR---GRVAVYPFDDHNPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKsaDEALAWYDEKR
..   | | .||..|..    .|  ..||| ..|. |..... . . .  ||.....||||| || ||.  ...  |. .|.|.  ..|. .  |||
tvvrvc.eptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGmky..edavefirekr

0051429 (Phosphotyrosine protein) phosphatases II 39-184 2e-12 42.8 In-house 24-218 (272) alignment
Range on Protein: 39-184
Range on HMM: 24-218/272.0
IIAMGYP---APDKLEGLFRNRLEDVFKLLEENHAQHYKIYNLCsersydvakFRGRVAVYPFDDHNPPTIELIQ-------------------------
....|.|    .. .. | ....  .. | .|.  ...| . .             |. ..|. |. .|||....                         
lyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw.........pgirylhlpilddsaptilygalrvtllseellldyilrellltlll

-----------------------RFCSDVDMWL-KedsSNVVAVHCKAGKGRTGTMICAYLVFSGIKKS------------ADEALAWYDEKRtkdRKGV
                         . ..  .| .   .. | |||.|||.||||.....|.  |. ..            ..||...  ..|   .. |
sagearevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqr...pgav

TIPSQRRYVQ
  . |.....
qteeqylfly

subfamily_DSP23_pd Subfamily DSP23 98-166 6.7e-12 40.3 In-house 59-124 (148) alignment
Range on Protein: 98-166
Range on HMM: 59-124/148.0
FDDHNPPTIELIQRFCSDVDMwlKEDSSNVVAVHCKAGKGRTGTMICAYLVFSgIKKSADEALAWYDEK
 ||. ||..| ...|   |.    |. .. |.|||  |.||||||.  |||    | .| ||.|   ..
iddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvke.rklaaaeaiaevrrl

subfamily_CDC14_pd Subfamily CDC14 56-183 8.7e-12 39.5 In-house 199-316 (328) alignment
Range on Protein: 56-183
Range on HMM: 199-316/328.0
NRLEDVFKLLEENHAQhyKIYNLCsERSYDVAKFRGRV---AVYPFDDHNPPTIELIQRFCSDVDMWlkedsSNVVAVHCKAGKGRTGTMICAYLVFSgI
.  | ...   .|. .  ..  |  .. ||  ||           | |   |. .....| . ..       .  .||||||| |||||.| .||.    
haPeklleyfrknnvt..tvvrLn.kklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkh.y

KKSADEALAWYdekRTkDRKGVTIPSQRRYV
. .| ||.||    |   | |. |  |....
rftaaeaiawl...ri.crPGsvigpqqkfl

PTPc_DSPc_SM00012 99-167 1.6e-11 39.7 In-house 11-83 (105) alignment
Range on Protein: 99-167
Range on HMM: 11-83/105.0
DDHNPP-TIELIQRFCSDVDMWLKEDS-SNVVAVHCKAGKGRTGTMICAYLVFSGIKKSA--DEALAWYDEKR
 ||. | . . | ... .|. . .. . |. | |||.|| |||||....... . ..|.   .. . .  | |
pdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelr

subfamily_DSP11_pd Subfamily DSP11 81-168 4.2e-11 37.0 In-house 67-158 (178) alignment
Range on Protein: 81-168
Range on HMM: 67-158/178.0
ERSYDVAKFRGRVAVY---PFDDHNPPTIELIQRFCSDVDMWL--KEDSSNVVAVHCKAGKGRTGTMICAYLVfSGIKKSADEALAWYDEKRT
.| |.  ..  .   |       |. |. ||...|.. |. .|  ..|. ....|||  |  ||| .|| ||. .    ....|.  ..| | 
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCryli.dvegyepedaieafeearG

subfamily_RNGTT_pd Subfamily RNGTT 102-169 8.4e-11 35.9 In-house 90-156 (189) alignment
Range on Protein: 102-169
Range on HMM: 90-156/189.0
NPPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVfSGIKKSADEALAWYDEKRTK
. |. | ...| . |. . |. ...|..|||. |  ||| .|..|||    . |...|.| . . | .
eaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLv.ekedwsveaavalFakaRpp

subfamily_PTPMT1_pd Subfamily PTPMT1 95-171 2e-09 32.1 In-house 78-152 (171) alignment
Range on Protein: 95-171
Range on HMM: 78-152/171.0
VYPFDDHN-PPTIELIQRFCSDVDMWLKEdsSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKRTKDR
 ..  |.   |..| ...    ..   ..   . | ||||||.||..|.. .||. .  | | .|||    .|| . |
qlatvDfteapdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkke.klspeeAlkalkkkRkiir

DSPc Dual specificity phosphatase, catalytic domain 122-167 3.1e-08 28.5 Pfam-A 70-114 (133) alignment
Range on Protein: 122-167
Range on HMM: 70-114/133.0
EDSSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKR
|.. . |.|||.||  |..|.|.|||  .  . |..||..   |.|
eqkgkkvlVHCqaGisRSatliiaYlmktk.nlslneAyefvkerr

DSPc Dual specificity phosphatase, catalytic domain 122-167 3.1e-08 28.5 In-house 70-114 (133) alignment
Range on Protein: 122-167
Range on HMM: 70-114/133.0
EDSSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKR
|.. . |.|||.||  |..|.|.|||  .  . |..||..   |.|
eqkgkkvlVHCqaGisRSatliiaYlmktk.nlslneAyefvkerr

PTPc_motif_SM00404 110-167 1.1e-07 26.8 In-house 70-121 (140) alignment
Range on Protein: 110-167
Range on HMM: 70-121/140.0
QRFCSDVdmwlkEDSSNVVAVHCKAGKGRTGTMICAYLVFSGiKKSADEALAWYDEKR
 .| ...     |..   | |||.||  |..|.|.|||  .  . |..||.  . |.|
ldfiena.....ekkggkvlVHCqaGvSRSatliiaYlmryr.qlslaeayefvkerR

subfamily_PTPN13_pd Subfamily PTPN13 75-161 1.7e-07 25.8 In-house 157-238 (273) alignment
Range on Protein: 75-161
Range on HMM: 157-238/273.0
IYNLCSERSYDVAKFRgrVAVYPfdDHNPP-TIELIQRFCSDVDMwLKEdSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADEALA
. .. |..| .||...   . .|  ||. | . . . .| . |   |.. ..  ..||| || ||.||.|. . |.  |..  .  . 
vkdsesgesrevahln..fvkwP..dhgvPssaaellqfvaevrr.lqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvk

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 63-156 6.5e-07 23.7 In-house 151-247 (319) alignment
Range on Protein: 63-156
Range on HMM: 151-247/319.0
KLLEENHAQHYKIYNLCSER-SYDVAKfRgRVAVYPF---DDHN-PPTIELIQRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSA
.|.||.. ..| | .|. .. | .|   | .|  . .    ||. | .  ..  .  ..    .. .|  . ||| || ||||| |    ..  .|. .
tleeeeeledyiirklklnkkssevet.R.evkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeeg

DSPc_SM00195 66-216 7.4e-07 24.1 In-house 134-247 (263) alignment
Range on Protein: 66-216
Range on HMM: 134-247/263.0
EENHAQ-HYKIYNLCSERSYD-VAKFRGRVAVYPFDDHNPP-TIELIQRFCSDVDMWLKEDsSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADealaw
|... . ......|  .   .  ...   . .    ||. | . . . .. . |. . ..  |. . |||.|| |||||.... .. | ...  .     
evekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekk.....

ydekrtkdrkgvtipsqrryvqyfsklvcssvpySKVSLNVCEIRFSESSCVQN
                                   ...  |.|.| .  ..||.
..................................vdifeivkelRkqRpgmvqt

PTPc_SM00194 66-216 7.4e-07 24.1 In-house 134-247 (263) alignment
Range on Protein: 66-216
Range on HMM: 134-247/263.0
EENHAQ-HYKIYNLCSERSYD-VAKFRGRVAVYPFDDHNPP-TIELIQRFCSDVDMWLKEDsSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSADealaw
|... . ......|  .   .  ...   . .    ||. | . . . .. . |. . ..  |. . |||.|| |||||.... .. | ...  .     
evekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekk.....

ydekrtkdrkgvtipsqrryvqyfsklvcssvpySKVSLNVCEIRFSESSCVQN
                                   ...  |.|.| .  ..||.
..................................vdifeivkelRkqRpgmvqt

Y_phosphatase Protein-tyrosine phosphatase 100-154 1.2e-06 23.5 Pfam-A 145-199 (235) alignment
Range on Protein: 100-154
Range on HMM: 145-199/235.0
DHN-PPTIELIQRFCSDVDMWLkEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKK
||. | . . . ... .|  .  |..|. | |||.|| |||||.... .... ...
dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

Y_phosphatase Protein-tyrosine phosphatase 100-154 1.2e-06 23.5 In-house 145-199 (235) alignment
Range on Protein: 100-154
Range on HMM: 145-199/235.0
DHN-PPTIELIQRFCSDVDMWLkEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKK
||. | . . . ... .|  .  |..|. | |||.|| |||||.... .... ...
dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqlea

subfamily_PTPN6_pd Subfamily PTPN6 64-155 2e-06 22.1 In-house 160-257 (306) alignment
Range on Protein: 64-155
Range on HMM: 160-257/306.0
LLEENHAQHYKIYNLCSERSYDVAKFRgRVAVYPF---DDHN-PPTIELIQRFCSDVDMWLKEDS---SNVVAVHCKAGKGRTGTMICAYLVFSGIKKS
 ..|.....|.. .|  ..  .  . | .|  | |    ||. |   . .  | .||..  .| .   .  . ||| || |||||.|   .. . |.|.
nvseksladYilRelsvskkkkkkeer.evfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekk

subfamily_PTPRB_pd Subfamily PTPRB 65-153 3.2e-06 21.4 In-house 157-246 (293) alignment
Range on Protein: 65-153
Range on HMM: 157-246/293.0
LEENHAQHYKIYNLCSERSYDVAKFRgRVAVYPFDDHN-PPTIELIQRFCSDVDMWL-KEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIK
..|.. ... | .|  |.. .  | | .     . ||. | . . . .|.  |. .. |. |.. . ||| || ||||| |.   ... |.
vaeeeledwvirelkiekekeerkvr.qyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaie

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 100-153 3.9e-06 21.2 In-house 187-241 (318) alignment
Range on Protein: 100-153
Range on HMM: 187-241/318.0
DHNPPT--IELIqRFCSDVDMWLKEDSSNVVAVHCKAGKGRTGTMICAYLVFSGIK
|.. |.   .|.  .  .|. . .. . ....||| || ||||. |    .   ||
degvpesgasll.dlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerik

subfamily_PTPN12_pd Subfamily PTPN12 100-157 4.6e-06 20.7 In-house 182-239 (290) alignment
Range on Protein: 100-157
Range on HMM: 182-239/290.0
DH-NPPTIELIQRFCSDVDMWLKeDSSNVVAVHCKAGKGRTGTMICAYLVFSGIKKSAD
||  | ... . .. ..|    . .... ..||| || |||||.|   .| . .|.   
DhgvPssaksllelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaeki

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 99-154 6.9e-06 20.3 In-house 173-230 (274) alignment
Range on Protein: 99-154
Range on HMM: 173-230/274.0
DDHNPPTIELIQRFCSDVDMWLKEDSSN--VVAVHCKAGKGRTGTMICAYLVFSGIKK
| . |  .. . ... .|.   .|.. .   | ||| || ||||  | . .    ...
dhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre