Gene Ptp36E in Drosophila melanogaster

Synonym: Dmel\CG7180, R-PTPk, Dmel_CG7180, CG7180

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Ptp36E
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP037_AA protein Get Run
DmelP037_AA_82-371 phosphatase_domain Get Run
DmelP037_AA_383-675 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_CG7180_pd Subfamily CG7180 387-679 1.7e-145 478.2 In-house 1-295 (296) alignment 
Range on Protein: 387-679
Range on HMM: 1-295/296.0
KAKARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGE
.||.......|......||....|.|||..|||||||.|..|||||||| .||.|..|..|....|....||||.|.||...|..||||||.|.|.|..|
dakkflklvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvde

FWSLVYDQECSAVVVLCQPPSQSQQYPSFWPNKSkMEKYGPVFsVHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWPMGHKVPS
||.||||.|.||||||.........|||.||||| .|.||..| |..|..|.|.|.|...||..||||.|||....|||.||.|.|||||.|....|||.
fWrlvydeeisavvvLtktfdfakmypsywpnks.keqygeif.veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPl

STNSLVYLMNMVEIWRNKV----DYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFLN
|||.|..|...|..||.||    ..|||.|||.||.||.|||.|..|..|.|....|||||.||||.||.|||||||..||||.||..|..||....
stnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_CG7180_pd Subfamily CG7180 84-376 1.7e-140 461.8 In-house 1-296 (296) alignment 
Range on Protein: 84-376
Range on HMM: 1-296/296.0
DIRHFLKLCDLRRKFPVLYKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQA
|...||||.| ||||.|.||||.......|...|...|.|.|.|||...|..|||||||||||..| ..|||.||.||||.||...||||..|..|||..
dakkflklvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvde

YWRMVWQENISAIVMLTKTFDFAKvMCHQYWPPNMevHEQYGDIFINIVREEQLANFHIRTFRLYKM------NEKQEVTDERLILQFHYTEWYS-HSCP
.||.|..|.|||.|.||||||||| |...|||...  .||||.||..||.|.|.||..||||.|.|.      .|||.....|....|..|||.. ...|
fWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvP

FS-NALLEFRRRVRLVVGNIikDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKT
.| |||.|.||||||.....  |||...||..|..|||..|||||..|||||||.|.||...||...|.||.||..||||||.||.|||.|.|...|.|.
lstnalielrrrvrlwrekv..dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd

W
.
k
subfamily_PTPRD_pd Subfamily PTPRD 96-433 7.3e-96 317.0 In-house 19-343 (564) alignment 
Range on Protein: 96-433
Range on HMM: 19-343/564.0
RKFPVLYKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISA
 .  .  . |...  . .. |...| |. | .||   . ..|| .||||.|| | ..|||.|||..|.  |..||| ||||..||.. .|||||..|.| 
ansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsst

IVMLTKTFDFAKVMCHQYWPPNmEvHEQYGDIFINIVREEQLANFHIRTFRLyKMNEKQEVtdeRLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGn
||||||. .  || ||.||| . . .|.||.. .... ||.||...||||.| |.....|.   | . |||.|.| .|  |   ..||...|.|| .   
iVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl.kkkksses...reVrqFhFtsWPdhgvpesatslLdlirkvralne.

iikdedDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNS
      . .|||.|||| | ||.|... ||| || ..||.  ....|.|.||. |. .|.. ||| ||.... | . ||.|  ....|...|.  |. ..
......pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLaevee

GTKMNEYQAEYDQICkQTPRFTIGDCAGGHRADNREKNR
.|.| ....|....   . .  . . | ...  |..|||
dtemtgleleFqrLa.takeieleefavatkpknkkknr
0040438 (Phosphotyrosine protein) phosphatases II 83-409 3.5e-84 278.1 In-house 3-315 (317) alignment 
Range on Protein: 83-409
Range on HMM: 3-315/317.0
IDIRHFLKLCDLRRKfpVLYKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQ
 |. ..|...... .   . . ||..  ..  .|...|....| .||..| ..|||..||.|  .||  ||||.||||||   .....|.|||| ..|| 
ldlllalldllksdf..talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntve

AYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPnmEVHEQYGDIFINIVREEQLANFHIRTFRLYKMnekqEVTDERLILQFHYTEWYSHSCP-FSNAL
 .|||||..... |||||..... ...|.||||   .   .|||...... ||.||....||......    .  ..| . .|||| |  |..|   . |
dFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl....gdsesrtvthfhytgWpdhgvppspdll

LEFRRRVRLVVGniikdedDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSE
|.| ..|| .         |  ||.|||||.| ||.|..  ..  ||. |.|....|.  .|.||. | | |.. |||.|.|| | |.. .. |. |.||
ldfleavreale.......dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepase

LSDRLKAKARRNSGTKMNEYQAEYDQIC
|  .|.   .   .... ... |.....
lklkllklliplalddvklkekelklll
0050432 (Phosphotyrosine protein) phosphatases II 87-377 3.9e-82 271.3 In-house 30-306 (308) alignment 
Range on Protein: 87-377
Range on HMM: 30-306/308.0
HFLKLCDLrRKFPVLYKLEFQTAA-KVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLekvgGlQDSDYVNASYVDSL--LKPNAYIVTQGPVEETVQA
..|||..   ... |.. ||..   . .......||...| .||. . ..|||..||.|    . ..|||.||||||     .|...|.|||| ..||  
dllkllek.aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntved

YWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNME-VHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEvtdeRLILQFHYTEWYSHSCPFS-NAL
.|||||..|.. ||||||...  .. |.||||....   ..||........||.|... .||..| .......    | . .|||| |  |..| | ..|
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges....rtvthfhytnWpdhgvPpspeil

LEFRRRVRLVVGNiikdeddmrGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWF
|.| ..|| . ..         |||.||||.| ||.|..  .|  ||. |.| ...||...||||. | | |...|||.|.|..| |.. . .|..
ldflelvrkslpg.........gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
0051299 (Phosphotyrosine protein) phosphatases II 95-370 2.9e-81 268.4 In-house 18-286 (288) alignment 
Range on Protein: 95-370
Range on HMM: 18-286/288.0
RRKFPVLYKLEFQTAAKVE-SNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENI
..... ... ||..  ..  ..|...||...|||||... ..|||..||.|  ..|  .|||.||||.|   .....|.|||| ..||  .|||||..|.
langltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnv

SAIVMLTKTFDFAKVMCHQYWPPnmEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVV
. ||||||.... .. |.||||.  . ...||||......||.|... .||... ...  .    .| . .|||| |  |..|   ..||.| |.|| . 
rvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

GniikdedDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHI
        .  ||..||||.| ||.|..  .|  ||. |.|....|....|.||. | |.|...|||.|.|..| |..
a.......sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0036941 (Phosphotyrosine protein) phosphatases II 112-381 2e-79 262.3 In-house 26-288 (297) alignment 
Range on Protein: 112-381
Range on HMM: 26-288/297.0
VESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLekvGGlQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCH
  . ....||...|||||. . ..|||..||.|   .. ..|||.||||||    ....|.|||| ..||  .|||||..|.. |||||. ..  ...|.
lllgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekca

QYWPPNMEVHEQYGDIFINIVREEQ--LANFHIRTFRLYKMNEKqevtDERLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGNIIKDeddmrGPILV
||||....   .|||.... ...|.  |.....||.........    ..| . .|||| |  |..|   . ||.| ..|| |  .. ..     ||.||
qywpleegesltygdftvtllsvevvllddytlrtlevtdtgng....esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg.....gpvlV

HCSDGGGRSGVYMSIDANLELAE---EEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSE
|||.| ||||..  .|  |.. |   .|...... ..||||. | | |...|||.|.|..| |.. ...|..|...
HCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 102-405 4.2e-79 260.9 In-house 25-318 (319) alignment 
Range on Protein: 102-405
Range on HMM: 25-318/319.0
YKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTK
 . ||..  . ...| ..| |..| .||. .  ..||  |||| .. | ..|||.|||..|.  . ...| ||.|.|.|.. .|||||.|..| .|||||
lekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltk

TFDFAKVMCHQYWPpnMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVtdeRLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVgniikdED
  .  || ...|||   | .|.|| . ...  ||.|... || . | | ... |    | . .|.||||  |  | .  .||.. .|.|  .      | 
lveklkvklkkywp..eenfeeyGrlivtleeeeeledyiirklklnkkssevet...RevkhfqyteWpdhdvPekatslldllkrirksr......ek

DMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNE
   ||| ||||.| || | .. .|| ||  .||.  .|| . ..||  |. .|.. |||||||..| | . .|.| . | .| ||||. | ....| .  
tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqlaekvadtgetg

YQAEY
 . |.
leref
0046845 (Phosphotyrosine protein) phosphatases II 105-378 1.9e-78 259.0 In-house 5-282 (284) alignment 
Range on Protein: 105-378
Range on HMM: 5-282/284.0
EFQTAAKVESN---TCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGL-QDSDYVNASYVDSL-----LKPNAYIVTQGPVEETVQAYWRMVWQENISA
||..  ..  .   ....||...||.||. . ..|||..||.|  ..|  .||||.||||||        .....|.||||...||  .|||||..|.. 
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

IVMLTKTFDFAKVMCHQYWPPNmEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQevtDERLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGN
|||||..... ...|.||||.. .   .|||.......||.  .. .||..| ... ..    .| . .||||.|  |..|  .. |||| | || .  |
IVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytg...esrtvthfhytswpdhgvppspedlleflrlvrellen

iikdeDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEE---CFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFP
      .  |||.||||.| ||.|..  .|  ||. |.|.   ...|....|.||. | | |...|||.|.|..| |.. ...|...
.....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
0047943 (Phosphotyrosine protein) phosphatases II 112-369 3.1e-78 258.3 In-house 25-271 (273) alignment 
Range on Protein: 112-369
Range on HMM: 25-271/273.0
VESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLekvgGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCH
 .. |...||...|..||... ..|||..||.|    | ..|||.||||||   .....|.|||| ..||  .|||||..|.. |||||....  .. |.
kplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekca

QYWPPNMEV-HEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQevtdERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVVGNIIKDeddmrGPILVH
||||....  ...||........||. ... .||..|.... ..    .| . .||||.|  |..|   . |||| . || .  .....     ||..||
qYwpleggelsltygkftvtllseetkddytvrtleltnlgtge....srtvthfhytgwpdhgvppslesllefielvrkalealpsn.....gpvvVH

CSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEH
||.| ||.|..  .|  |.. |.| ...|. ..|.||. | | |...|||.|.|..| |.
CsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0039614 (Phosphotyrosine protein) phosphatases II 94-376 6.6e-78 257.5 In-house 26-295 (297) alignment 
Range on Protein: 94-376
Range on HMM: 26-295/297.0
LRRKFPVLYKLEFQTAAKVESNtCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGL-QDSDYVNASYVDSLLK-PNAYIVTQGPVEETVQAYWRMVWQE
...... |..|||..  ..  . ...||...| .||. . ..|||..||.|  ..|   ||||.||||||   . ....|.|||| .|||  .|||||..
ekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweq

NISAIVMLTKTFDFAKvMCHQYWPPNMEvheQYGDIFINIVREEQLANFHIRTFRLYKmnEKQEvtdeRLILQFHYTEWYSHSCP-FSNALLEFRRRVRL
....||||||...  . .|.||||....   .|||.... ...|.|.....||... .  ....    | . .|.|| |  |..|  .. |||| . || 
gvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..nges....rtvthfqytgwpdhgvppslellleflelvre

VVGNIikdedDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTW
.. .      .  ||.|||||.| ||.|..  ..  ||. |.| ...|.  .|.||. | | |.. .||.|.|| | |.. ...|.
alael.....pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkltl
subfamily_PTPRK_pd Subfamily PTPRK 118-402 3.7e-76 251.0 In-house 36-309 (314) alignment 
Range on Protein: 118-402
Range on HMM: 36-309/314.0
RHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPN
  | |..| |||.  . ..||  ||.|  . | ..|||.||...||  .|.|.||||||..|||. .||.|..|| ..|||||.  . ..| | .||| .
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

MEVheqYGDIFINIVREEQLANFHIRTFRLYKMNEKQEvtDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGNiikdeddMRGPILVHCSDGGGR
 ||   |||| ...|. | ||.. .|.||..|.. .||  . |.. ||... | .|  | | ..||.. |||     .         |.|.|||| |.||
tev...ygdikvelvetellaelvvrifrveklargqe..eirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.......eaGrivvhCsaGaGr

SGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNEYQ
.|... ||  |...|.|.  .||   |.||...  .||  |||||||| . |  .||.|  ||||.    .   | .. |.  . .
tGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesirldpqtnssqlk
0043336 (Phosphotyrosine protein) phosphatases II 93-369 1.2e-75 249.9 In-house 13-276 (278) alignment 
Range on Protein: 93-369
Range on HMM: 13-276/278.0
DLRRKFPVLYKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQEN
.| .... |..|||..  ..  .|...||...| .||. . ..|||..||.|. .||  ||||.||||||   .|...|.|||| .|||  .|||||...
elllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

ISAIVMLTKTFDFAKVMCHQYWPpnmEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEvtdeRLILQFHYTEWYSHSCP-FSNALLEFRRRVRLV
.. |||||. ... .| |.||||   . ...|||.... ..||.|.....||... .. ....    | ....||. |  |..|   . ||.| ..|| .
vttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdges....rtvthyhylgwpdhgvpeslsllldflkavrea

VGniikdedDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEH
.        |  ||.|||||.| ||.|... ..  ||..| | .....  .|.||. | | |.. .||.|.|. | |.
le.......dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 96-370 2.9e-75 249.2 In-house 23-304 (307) alignment 
Range on Protein: 96-370
Range on HMM: 23-304/307.0
RKFPVLYKLEFQTAAKVE---SNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGL-QDSDYVNASYV--------DSLLKPNAYIVTQGPVEETVQA
..|. ... ||..  .|.   ......||...| .||. . ..|||..||.|  ..|  .||||.|||||        |.  .....|.|||| .|||  
ldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

YWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNmEVHEQYGDIFINIVREEQLANFHIRTFRLYKMnekQEVTDERLILQFHYTEWYSHSCP-FSNALL
.|||.|......|||||.........|.|||| . . . .||..... ..||.|.....||...  .   ..   .| . .||||.|  |..| . . ||
FwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl...dgtgesrtvthfhytgwpdhgvppsfeell

EFRRRVRLVVGNIIKDeddmrGPILVHCSDGGGRSGVYMSIDANLELAEEEEC---FNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHI
.| ..|| ....  |.     ||.|||||.| ||.|... ..  |.. |.|..   ....  .|.||. | | |.| |||.|.|. | |..
dfieevrkaleelpkg.....gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 92-407 3.2e-74 244.8 In-house 12-317 (318) alignment 
Range on Protein: 92-407
Range on HMM: 12-317/318.0
CDLRRKFPVLYKLEFQTA-AKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQ
  ||..  .|.. |..    . |. |  ..|.. |  ||.    ..||  || |... | ..|||.||.|.|   . .||| .|.|. ||.. .|||||.
rrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWe

ENISAIVMLTKTFDFAKVMCHQYWPPNMevHEQYGDIFINIVREEQLANFHIRTFRLYKmnekQEVTDERLILQFHYTEWYSHSCPFSNA-LLEFRRRVR
 | . |||||.. . .|. .|.||| .    ..||.. ...  | .|... .|.|.. .    .|. ..| . |.|||.|  .. | | | ||.. |.|.
qnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtr....teeeesrqvrqyhytsWpdegvpesgaslldlvrqvs

LVvgniikDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAK
 .      ...  .|||.|||| | || ||.. .|. || ...|.  .||.. |.||. |. .|   .||.||||.| | ...|.|    |.|..|..  
ka......qqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirel

ARRNSGTKMNEYQAEYDQ
 .... . . | .||...
reqdpesgttemdaefqr
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 90-375 2.9e-72 238.5 In-house 16-295 (298) alignment 
Range on Protein: 90-375
Range on HMM: 16-295/298.0
KLCDLRRKFP-VLYKLEFQTAAKVES----NTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAY
|| . ..|.  . |.||||.  .|.|    .. . | |..| .||  .. |..|. ||||||. . ..|||.|||....  . ||.|.||.|..|||. .
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedF

WRMVWQENISAIVMLTKTFDFAKVMCHQYWPPnmEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKqevtDERLILQFHYTEWYSHSCPF-SNALLE
||||..|.|..|||||.. .  |. .|.|||   | .|.||.| ... ..|. |.. .|.. . | .|.    .|| . |.|.|.| ... |  ....|.
WrmvteedigtiVmltnleeldktkyhkywPd..egketygeitvsllskeefadlivrklkvskkkee....kerevrqlhftsWpdkgvpenatsvld

FRRRVRLvVgniikDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKT
..|.||         ..    |..|.||.| |||| .. ||. || ...|.   || ..| ||..| |.|.  |||.|||.   | . ....
llrkvra.s.....qqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd
0040439 (Phosphotyrosine protein) phosphatases II 115-370 1.9e-71 235.9 In-house 1-246 (249) alignment 
Range on Protein: 115-370
Range on HMM: 1-246/249.0
NTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYW
.....||...|..||..| ..|||..||.|. ..|| .|||.||||.|    ....|.|||| .||| ..|||.|...|..|||||... . .. |.|||
geysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PPnmEVHEQYGDIFINIVREEQLANFHIRTFRLYKMnekqEVTDERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVVGNIikdedDMRGPILVHCSDG
|.  . . .|||.... ...|.......||..|...    .  ..| .|...|| |  |..| . . ||.| ..|| .. ..     .  ||.|||||.|
pl..ggsleygdftvtllsvevkddytvrtleltnl....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.....pkggpvlVHCsaG

GGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHI
 ||.|..  ..  ||. |.| ..... ..|.||. | | |.| |||.|.|. | |..
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 105-386 2e-71 235.7 In-house 27-299 (305) alignment 
Range on Protein: 105-386
Range on HMM: 27-299/305.0
EFQTAAKVeSNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFD
.... ..  ....    |..| .||.. . ...| .|. | .   |.||||.||||||.  . ..|||.|||...||. .||....| .| ||||||. .
qykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklve

FAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEkqeVTDERLILQFHYTEWYSHSCP-FSNALLEFRRRVRlvvgniiKD-EDDM
  |  |.|||| ..  ....|.. ...  |.. ... .| ... . .|     ..| .||.. |.|  |  | |. .||.. .||.       || . | 
ggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede...dkesrtvlqyqltdWPdhGvpqfatsllslikrvq.......kdqkkdk

RGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRL
  |.|||||.| ||.||....|  || ...||  .||..||.||..| ..|.. .|| |..| |.| |.||.|   .| |. |.
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv
subfamily_Ptp69D_pd Subfamily Ptp69D 102-387 1.5e-70 232.7 In-house 24-303 (307) alignment 
Range on Protein: 102-387
Range on HMM: 24-303/307.0
YKLEFQTAA-KVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLT
.. |...   .  . ... . ||.|. ||. .. ...| .||.|.|. | .||||.|||.. .  . . .|. |.|||.|.. .|||... ..  ||||.
lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmls

KTFDFAKVMCHQYWPPNmeVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQ-EVTDERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVVGNIikd
.  .  .  |..||| .     ||||| ...|.||.  .. ||.. . |..|.  || |.| ..|.|||.|     |  ...||.. ..|| .  .    
nlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln...

eddmRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLK
    |.||.|||| | ||||.....|  |.  ..|.. ..|   |.||. |. ||.. |||.|.|  | ...  |.|   | .|.|...
....rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledaie
DSPc_SM00195 107-368 2.5e-70 232.2 In-house 7-260 (263) alignment 
Range on Protein: 107-368
Range on HMM: 7-260/263.0
QTAAKV-ESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDF
..  .  .......| ||.| .||.  ...||| .|| |.|  . ..|||.||.|..   |...||.|||| ..||. .|||||.|... |||||. .. 
ekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

AKVMCHQYWPPNMEVHEQYGDIFINIVREEQLA-NFHIRTFRLYKMNEkqevTDERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVVGNIikdeddmR
 |  |..||| ...  |..|.| ...|..|.   ....||..| | ..     ..| . |..|..|  |..|   . .||. | |.    ..        
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......s

GPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEE
|||.||||.| ||.|....||  |.  |||. ...|  .|.||..| |.|.. |||.|||... |
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 107-368 2.5e-70 232.2 In-house 7-260 (263) alignment 
Range on Protein: 107-368
Range on HMM: 7-260/263.0
QTAAKV-ESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDF
..  .  .......| ||.| .||.  ...||| .|| |.|  . ..|||.||.|..   |...||.|||| ..||. .|||||.|... |||||. .. 
ekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

AKVMCHQYWPPNMEVHEQYGDIFINIVREEQLA-NFHIRTFRLYKMNEkqevTDERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVVGNIikdeddmR
 |  |..||| ...  |..|.| ...|..|.   ....||..| | ..     ..| . |..|..|  |..|   . .||. | |.    ..        
gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......s

GPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEE
|||.||||.| ||.|....||  |.  |||. ...|  .|.||..| |.|.. |||.|||... |
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
Y_phosphatase Protein-tyrosine phosphatase 125-366 7.9e-70 230.3 Pfam-A 1-233 (235) alignment 
Range on Protein: 125-366
Range on HMM: 1-233/235.0
NLEKNQNPKCIPYDYNRVVLEKVGGLQDsdYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQY
|..||......||| .|| |.. .| .|  |.||.||..  .....|.||||...|.. .|||||||....|||||.  .  .. |.|||| ..|  ..|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIFINIV-REE-QLANFHIRTFRLYKMNEKQevtDERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVVgniikdeDDMRGPILVHCSDGGGRSGVYM
|||..... .|. . ... .|...| | .|..   ..| . |.|||.|  |..|  ...||.. |.|.          .. .||..||||.| ||.|...
gdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkveksk.......eaksgpvvVhCsaGvgRtgtfv

SIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL
..|. || .|.||...|. ..|.||..| |.|...|||.|.|...
aldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 125-366 7.9e-70 230.3 In-house 1-233 (235) alignment 
Range on Protein: 125-366
Range on HMM: 1-233/235.0
NLEKNQNPKCIPYDYNRVVLEKVGGLQDsdYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQY
|..||......||| .|| |.. .| .|  |.||.||..  .....|.||||...|.. .|||||||....|||||.  .  .. |.|||| ..|  ..|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDIFINIV-REE-QLANFHIRTFRLYKMNEKQevtDERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVVgniikdeDDMRGPILVHCSDGGGRSGVYM
|||..... .|. . ... .|...| | .|..   ..| . |.|||.|  |..|  ...||.. |.|.          .. .||..||||.| ||.|...
gdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkveksk.......eaksgpvvVhCsaGvgRtgtfv

SIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL
..|. || .|.||...|. ..|.||..| |.|...|||.|.|...
aldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPRA_pd Subfamily PTPRA 112-400 8.2e-69 227.0 In-house 45-325 (330) alignment 
Range on Protein: 112-400
Range on HMM: 45-325/330.0
VESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCH
   .|.  | |..| |||. .. .|||..||.| .. | ..|||.|||..|   . . .| .||| ||||. .|||.|. . ..|||||.  .  .  |.
piqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekca

QYWPPNMEVheQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPFSN-ALLEFRRRVRlvvgniiKDEDDMRGPILVHC
|||| .  |   ||.| ...  |. | .. .| | . .......  ..||. |||.| |     ||    .|.. ..|.       | .. . ||| |||
qywPdeGlv..tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk.......klnqqsagpivvhc

SDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNE
| | ||.| .. .|| ||  . |.  .||. .|.||. |  .|   |||.||| .| |. . | | . || |  .|.    . .||. . 
saGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhlqklynkitgtdkig
subfamily_PTPRG_pd Subfamily PTPRG 106-382 1e-68 227.0 In-house 28-299 (563) alignment 
Range on Protein: 106-382
Range on HMM: 28-299/563.0
FQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDS-DYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFD
 |.  . .. .. |. |..| .|| . . ..||  || |... | ... ||.||.|.|   | .|.|.||||...|.. .|||.|..| . |||.|.  .
lqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlve

FAKVMCHQYWPPnmEVHEQYGDIFINIVREEQLANFHIRTFRLYK--MNEKQEVTDERLILQFHYTEWYSHSCPFSNA-LLEFRRRVrlvvgniIKDEDD
  .  |..|||   .  |.|| . .....||.||   .||. . .  ...|..  .|.|. |.|||.|  |. | ...  | | ..         . . .
rgrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks.......saanka

MRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSEL
  |||.|||| |.||.|.|. .|. |.  ..|.  |||| ||..|  |  ||.. ||| |..|.| | |  ..|    ...
eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv
0042113 (Phosphotyrosine protein) phosphatases II 117-367 1.1e-68 226.6 In-house 1-240 (245) alignment 
Range on Protein: 117-367
Range on HMM: 1-240/245.0
CRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPP
...||...| .||... ..|||..||.|  .||  ||||.||||||    .. .|.|||| .|||...|||.|...|..|||||..... .| |.||||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

nmEVHEQYGDIFINIVREEQLANFHIRTFRLYKMnekqEVTDERLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGNiikdedDMRGPILVHCSDGGG
  . . .|||.... ..||.|.....||... ..        .| ....||. |  |..|  .. ||.| ..|| .. .      |  ||.|||||.| |
..gesltygdftvtllseehlddytvrtlevtnl....gddesrevihyhylpwpdhgvpdllellldflefvrkalae......dsngpvlVHCsaGvg

RSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLE
|.|... ..  ||..|.| .....  .|.||. | | |.. .||.|.|. | 
RtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0045098 (Phosphotyrosine protein) phosphatases II 112-374 3.7e-68 225.2 In-house 20-276 (278) alignment 
Range on Protein: 112-374
Range on HMM: 20-276/278.0
VESNTCRHALKKNNLEKNQNPKCIPYDYNRVVlekvgglqdsDYVNASYVDSLlkPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCH
   ... .||. .||.||  .  .|||..||.          ||.||||.|.   |...|.|||| ..||...|||.|...|..|||||. .. ... |.
gipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

QYWPPnmEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPFSN---ALLEFRRRVRLVVGNIIKDE------DDM
||||.  . ...|||...... ||.| ....||....  . ..|   .| . ..||. |  |..| ..    .||. ...| .. ....        .| 
qywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

RGPILVHCSDGGGRSGVYMSIDANLELAeeEECFNVFGYLKKLRQSRKG-LVENVEQYKFIYDTLEEHIICGK
 ||.||||| | ||.|..  ..  |||   |. .... ..|.||. | |  |.| |||.|.|. | |.. .||
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_PTPRB_pd Subfamily PTPRB 100-368 4.8e-68 224.3 In-house 25-283 (293) alignment 
Range on Protein: 100-368
Range on HMM: 25-283/293.0
VLYKLEFQTAAKVE-SNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVM
. .. |...  .|. ....  | .. | .||.  . .|||..|| |... . ..|||.||.|.. .  |. .|.||||. |||. .|||||... |.|||
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LTKTFDFAKVMCHQYWPPNMEvHEQYGDIFINIVREEQLANFHIRTFRLYKmnekqeVTDERLILQFHYTEWYSHSCPF-SNALLEFRRRVRlvvgNIIk
||....  || |..||| . |   .|||| ...| ||.| .. ||.... |       ..|| . |.|.| |  |  |  ...||.| |.||    . | 
ltqlvekgkvkCeeYWPadee.pvlyGdikvtlvaeeeledwvirelkiek......ekeerkvrqyhftsWpdhgvPektktlldfvrtvr....eai.

DEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEE
...  ..||.|||| | ||.|.....|  |.  |||.. ..|| . .||..|. || ...|| ||.... .
ektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 121-372 1.9e-65 215.5 In-house 5-244 (250) alignment 
Range on Protein: 121-372
Range on HMM: 5-244/250.0
LKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVmCHQYWPpnMEV
 | .|.|||.  . |..|  ||||||. | ..|||.|||....  . .|.|.||||...|.. .||||..|....|||||.  .  |. .|||||  .|.
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..vek

HEQYGDIFINIVREEQLANFHIRTFRLYKMNEkqevTDERLILQFHYTEWYSHSCPF-SNALLEFRRRVRLvvgniiKDEDDMRGPILVHCSDGGGRSGV
 |.|||. ...  .|. |.. .|.. | | ..    .|||.. |.|.. |   . |   .| ||....|.       ...    .|..|.|| | |||| 
aekyGdvtvsllskeefadytkrklklskakk....aderivrqlhfvvWPdkgvPevatavLellkkvqa......sqqqagnaPvivqCsaGvgrsGa

YMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIIC
.. ||| || ...|.  .|| ..|.||. | . ||  ||| |.|  . . . .
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 105-367 6.7e-65 214.0 In-house 26-276 (288) alignment 
Range on Protein: 105-367
Range on HMM: 26-276/288.0
EFQTAAKVESNT-CRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTF
|... |..|..     . . .| .||. .  .|||..|| |.|.   ...||.||||.|.  | ..|| ||||. .||. .|..|.....| |||||.  
eynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelv

DFAKVMCHQYWPpNMEVHEQYGDIFINIVREEQLANFHIRTFRLYkmnekqEVTDERLILQFHYTEWYSHSCPFSN-ALLEFRRRVRlvvgnIIKDEDdm
.  |  |..||| . . ...||.. . .| ...| .|  |.. |         ..|. | |..|. |  |. | |.  |||..| |      . ...|  
eggktkCeeYWP.dadkpknyGsvtvtlveskeledfvlrkllle......kkkteleitqyqylaWpdhgvPeskapllellrqvk.....vanqad..

RGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLE
 |||.||||.| ||.|.....|| ..  |||.  .|.| ..|||..|. ||....|| |||..| 
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 103-374 8.8e-64 210.8 In-house 37-295 (319) alignment 
Range on Protein: 103-374
Range on HMM: 37-295/319.0
KLEFQTAAKVESN--TCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLT
. ||. |.|.  |  .  .|  ..| .||.  . ...| |.| ||.. | . |||.|||.|.   ... || .||| ..|.. .|||.|. |.|.||.||
evefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt

ktfdfaKVMCHQYWPPNMEVHEQYGDIFINIVREEQLanFHIRTFRLykmNEKQEVTDERLILQFHYTEWYSHSCPFSNA-LLEFRRRVRlvvgnIIKDE
      | .| |||| .....|. ... .. | | .   . .| ..|    |. . .| | | |||.  |  .  | . . |. . ..||      ... 
......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdiel...sedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvr.....hltsk

DDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGK
 . | .|.|||| | ||.|||. .|. |.  .||.  .|. ... ||| |. ||... |||||| .| |. . |.
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 105-375 5.1e-63 208.2 In-house 3-260 (284) alignment 
Range on Protein: 105-375
Range on HMM: 3-260/284.0
EFQTAAKVESN--TCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTkt
||. |.|.  |  .  .|  ..| .||.  . ...| |.| ||.. | . |||.|||..    ... || |||| ..|.. .|||.|. |.|.||.||  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

fdfaKVMCHQYWPPNMEVHEQYGDIFINIVREEQLanFHIRTFRLykmNEKQEVTDERLILQFHYTEWYSHSCPFSNA-LLEFRRRVRlvvgnIIKDEDD
    | .| |||| .....|. ... .. | | .   . .| ..|    |. . .| | | |||.  |  .  | ... |. . ..||      ...  .
....kdkcsqywplkivikeerfkvkvdsveesee..yvvrdiel...sedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvr.....hltsken

MRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKT
 | .|.|||| | ||.|||. .|. |.  .||.  .|. ....||| |. ||... |||||| .| |. . |..
hranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
0051299 (Phosphotyrosine protein) phosphatases II 374-674 6e-63 208.3 In-house 2-286 (288) alignment 
Range on Protein: 374-674
Range on HMM: 2-286/288.0
KTWFPVSELSDRLKAKArrnsGTKMNEYQAEYDQICKQTPRftiGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREY
.|...|.|| ......      . .. ...|........|    ...  ...  |.|||| . ..| |. | .|....|. ..||||  ..||| ..|..
dteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkf

IVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQS-QQYPSFWPNkSKMEKYGPvFSVHYVMSKSYTNIKQWEFKINKKIV-SltemmagVKAPTRTVQ
|.|..|...|...|| .|..|... .|.|...   . .... .||. .....||. ..|...  ... ......... .. . .        .  .|||.
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygd.itvtllseevlddytvrtlevtnldlld.......gdgesrtvt

LFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRNkVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVL
 |. | ||  | ||.|...|. ....|  ...  . |||.| . .| .|.|...|.  ..||. ..|.|||..|||..|..||..|..   |...|...|
hfhytnwp.dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall

HYV
.|.
eyl
0037934 (Phosphotyrosine protein) phosphatases II 116-368 2.9e-62 205.7 In-house 1-240 (243) alignment 
Range on Protein: 116-368
Range on HMM: 1-240/243.0
TCRHALKKNNLEKNQNPKCIPYDYNRVVLekvgglQDSDYVNASYVDSLlkPNaYIVTQGPVEETVQA----YWRMVWQENISAIVMLTKTFDFAKVMCH
....||...||.||. . ..|||..||.|      ..|||.||.... .  |. .|.|||| .|||.     .|||.|...|..|||||....  .. |.
sfsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

QYWPpnMEVheQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVtdeRLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGN-----IIKDEddmrGP
||||   ||  .|||...... ||.|.....||..|.  ......   ||. ..||. |  |..|   . ||.| . || .. .      ....    ||
qywp..gev..tygdftvtllseehlddytvrtlllenldlddlt...rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg....gp

ILVHCSDGGGRSGVYMSIDANLELAeeeeCFNVFGYLKKLRQSRKG-LVENVEQYKFIYDTLEE
.||||| | ||.|..  ..  |.|     ..... ..|.||. | |  |.. .||.|.|. | |
vlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 102-370 3.4e-62 205.1 In-house 17-276 (281) alignment 
Range on Protein: 102-370
Range on HMM: 17-276/281.0
YKLEFQTAAKVESNTCRHALK-KNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLT
.. |... |... .   .| | ..| .||.    . ||  ||....    ...||.||..|... ....||.||||| ....|.|.|||....|||||.|
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvt

KTFDFAKVMCHQYWPpNMEVHEQYGDIFINIVREEQLANFHIRTFRLyKMNEkqevTDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVvgniikDE
.  .  |. ||.||| . . . .|||. .. ..||. |..  |.|.| ....    ...| . |..|| |  |  | . ..|||||. |. .      .|
reieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eres....getreveqlaytaWPdhGvPattkellefrkevlkl......te

DDMRGPILVHCSDGGGRSGVYMSIDANLELAEEE-ECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHI
 .   |...||| | ||.|.|...|  .. .|.| |  .|   ...||..|. .|  | ||.|.| .. . .
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN6_pd Subfamily PTPN6 109-370 1.6e-61 202.9 In-house 38-297 (306) alignment 
Range on Protein: 109-370
Range on HMM: 38-297/306.0
AAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEkVGGLQDSDYVNASYVDS--LLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFA
 .. .  . ... |..| |||.    .|.| .||.|.   ....|||.||.|...    . ..|| ||| .|.||. .||||||||   |||.||  . .
eeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErg

KVMCHQYWPPNMEVHEqYGDIFINIVREEQLANFHIRTFRLYKMnekQEVTDERLILQFHYTEWYSHSCPFSNA-LLEFRRRVRLVVGNIIKDeddMRGP
| .| .||| . | .| ||.| .. |.|..||.. .|.... |.   .. ..|| . |.|...|  |..| .   .|.| . |.    .. .      ||
kekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk...kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea...eagp

ILVHCSDGGGRSGVYMSIDANLELAEEEEC---FNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHI
|.||||.| || | .. ||. |.| |.. .   ...    |..|. |.|||   .||||.| .....|
ivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 120-434 4e-61 201.7 In-house 38-340 (515) alignment 
Range on Protein: 120-434
Range on HMM: 38-340/515.0
ALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNME
| .. | .||.    .||| .|| || .    .|||.||||. |.   .||| .||| . .|. .||.|.|||...|.|.||  .  |. | .|||    
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

VHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTderlilQFHYTEWYSHSCP-FSNALLEFRRRVRlvvgniiKDEDDMRGPILVHCSDGGGRSG
   ..| | ...|  |  ..  .|.... | .. . ||      |||.|||  .  |  ...|| . . |.        |.. .  |...||| | || |
dsvkfGsikvelvsleactggikrkltvlkgddsrtvt......qfhfteWPdkGvpkhtssllklikevk.......adhgqythpliihcsaGvGrtG

VYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTIG
|..|||  .  |.. .  .|| .....|| |  ||   ||| |||... |..   .|  ||  ..| |.       |        |.. .   .|     
vvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlkslcpdppas

DCAGGHRADNREKNRD
..  |.  ||. ||| 
qtrsgrtrdnhpknry
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 116-375 5.6e-61 201.2 In-house 40-284 (315) alignment 
Range on Protein: 116-375
Range on HMM: 40-284/315.0
TCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWP
  . | | .| .||.  . |.||  || |  .   ..||||||...|   |.. || .|||  ..|. .||.|..|.|. |||||.. .  | .. .|||
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

PNmevHEQYGDIFINIVREEQLANFHIRTFrlyKMNEKQEVtdeRLILQFHYTEWYSHS-CPFSNALLEFRRRVRLVVGNIIkdeddmrGPILVHCSDGG
 .   .  || | .  . ||.  .. .||.    .  ....   | ..|.||| |     . .. .|... |.|.    | .       |.|.||||.| 
dk...kviyGkitvtrkseevnteytvrtl...svvfgdni...revvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.......gaivvhcsaGv

GRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKT
||.| ....|| |. || |.  .|. .....|| |...|. .|||.||||.| | ..|| |
GrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdt
subfamily_PTPN12_pd Subfamily PTPN12 111-369 8.5e-61 200.4 In-house 25-276 (290) alignment 
Range on Protein: 111-369
Range on HMM: 25-276/290.0
KVES-NTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVM
| |.  .  .. |..| .||.    .|||..||.|.|  . ..|||.||...    .. .|| .|||. .|.. .|||.|. |.. .||. . .. .|  
kaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkk

CHQYWPPNMEVHEQYGDIFINIVREEQLA-NFHIRTFRLYKMnekqevTDERLILQFHYTEWYSHSCPFSN-ALLEFRRRVRLVVGniikdedDMRGPIL
|..||| ..| . ..|.. ..  .|...  .| |||... .        ..| . |||||.|  | .| |   |||. . || .         .   |..
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq......kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.......sedaPlv

VHCSDGGGRSGVYMSIDANLELAE---EEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEH
|||| | || |. ..||   || .    .|...||  . .||. |. ||   |||...| ...| 
vhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 83-407 2.3e-60 199.1 In-house 3-314 (315) alignment 
Range on Protein: 83-407
Range on HMM: 3-314/315.0
IDIRHFLKLCDLRRkFPVLYKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQ
| . .|  . .  | .  |.  ||.     .    | | ...| .||.    .|.| .||.|| .    ||||.||||. |. . .||| .||| . .|.
ipvaqfpafvnknr.htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvd

AYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVTderlilQFHYTEWYSHSCPF-SNAL
 .||||.||....|||.||  .  |. | |||| .     ..| | ....  |. ..  .| . . | .|.. ||      ||..|||  .  .  . .|
dfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvt......qfqftewPdkGvdkqtssl

LEFRRRVRlvvgniiKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSE
|.. . |.        |..    ..||||| | ||.|| .|||  .. .....  .|| ..|.||. |  ||   |.| ||||.. |..   .|  .|  
lklikevk.......adngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvih

LSDRLKAKARRNSGTKMNEYQAEYDQ
..|.|.      .|.  ..   |...
ftdhlqdlhtsvdgsgrskmtkefet
0039614 (Phosphotyrosine protein) phosphatases II 393-679 8.6e-60 198.0 In-house 26-294 (297) alignment 
Range on Protein: 393-679
Range on HMM: 26-294/297.0
NSGTKMNEYQAEYDQICKQTPrftigDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGN-AFTDYINSVFVDGYTK-PREYIVTEWPMKHTLGEFWSL
.  .... ...|. ......|     |.  ...  |..||| . ..| |. | .|... |    .||||  .|||| . .|..|.| .|...|.. || .
ekansktllllefeellslkp.....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

VYDQECSAVVVLCQPPSQSQQYPSFWPNKSKmeKYGPvFSVHYVMSKSYTNIKQWEFKINKkivsltemmagvKAPTRTVQLFQLTCWPmGHKVPSSTNS
|..| ....| |...   .......||...   .||. |.|...  . . ......... .            . ..|||. || |.||  |.||.|...
vweqgvtvivmLtklvelgrkcaqywpeegg..tygd.ftvtllkvehldgytvrtlevtn............ngesrtvthfqytgwp.dhgvppslel

LVYLMNMVEIWRNKV-DYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFLN
|  ....|. ....  . |||.| . .| .|.|...||  ..||.  .|.|||..|||..|..||. |...  |...||..|......|.
lleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0050432 (Phosphotyrosine protein) phosphatases II 395-680 7.3e-59 195.0 In-house 38-305 (308) alignment 
Range on Protein: 395-680
Range on HMM: 38-305/308.0
GTKMNEYQAEYDQICKQTPrftIGDCAGGHRADNREKNRDVLCVPPDNFRPYLtsfqgNAFTDYINSVFVDGY--TKPREYIVTEWPMKHTLGEFWSLVY
 . .  ...|. ......|   ....  . . .|..||| . ..| |. | .|     .  .||||  .||||   .||..|.| .|...|.. || .|.
aldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

DQECSAVVVLCQPPSQS-QQYPSFWPNK--SKMEKYGpVFSVHYVMSKSYTNIKQWEFKINKKIvsltemmagvKAPTRTVQLFQLTCWPmGHKVPSSTN
.|... .|.|...   . .... .||..  .. ..||  |.|...  ... ......... ..           . ..|||. |. | ||  |.||.|..
eqnvrvIvmLtklvengrekcaqYwplelgggsleyg.kftvtllseevlddytvrtleltnlg..........dgesrtvthfhytnWp.dhgvPpspe

SLVYLMNMVEIWRNKvdyGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFLNK
.|. ....|. ....   ||..| . .| .|.|...|.  ..||. ..|.||||.|||..|..||. |..   |...|...|.|.. .|.|
illdflelvrkslpg...gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
0046845 (Phosphotyrosine protein) phosphatases II 402-679 7.3e-59 194.8 In-house 3-279 (284) alignment 
Range on Protein: 402-679
Range on HMM: 3-279/284.0
QAEYDQICKQTPRFTiGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGN-AFTDYINSVFVDGY-----TKPREYIVTEWPMKHTLGEFWSLVYDQE
..|. .....|. ..  ..  ...  |..||| . ..| |. | .|.|..|.   .||||  .||||      .....|.| .|...|...|| .|..|.
eeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CSAVVVLCQPPSQS-QQYPSFWPNKSKMEKYGPvFSVHYVMSKSYTNIKQWEFKINKKivsltemmaGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYL
.. .|.|... . . .... .||..... .||. |.|...  . . ......... ..         |.. ..|||. |. | ||  |.||.|...|. .
vrvIVmltelvengrekcaqYwplegevltygd.ftvtllseevkddytvrtleltnl.........gytgesrtvthfhytswp.dhgvppspedllef

MNMVEIWRNK-VDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHG---EVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFLN
...|. ....  . ||..| . .| .|.|...|.  ..||....|   .|||..||| .|..||. |..   |...|...|.|....|.
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 106-368 1.4e-57 189.8 In-house 26-281 (290) alignment 
Range on Protein: 106-368
Range on HMM: 26-281/290.0
FQTAAKV-ESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQD--SDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKT
|..  .  ...|  ..| ..| ..|   ....|| ||..| ...| .|   .|.||.|..   . ..||.|||||..|.  .|...|||....|||||. 
fkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltni

FDFAKVMCHQYWPPNmEVHEqYGDIFINIVREEQLANFHIRTFRLYKMNEKqevTDERLILQFHYTEWYSHS-CPFSNAllefrrrVRLVVGNIIK-DED
 .  || |.|||| . .... || . |... ||.| .. .|.... ..|..    ... . |.. | | |.  ..  ..       . ||. ...|    
ieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsa...gakqsvtqyqitnwdstgkvtnpqt.......illvieemyktqrk

DMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEE
. ...|.|||||. |||.|.....  .. .. |   .||  ||..|. . |.|. |.||..|.. . .
rgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
subfamily_PTPN9_pd Subfamily PTPN9 113-369 1.4e-57 190.0 In-house 30-289 (297) alignment 
Range on Protein: 113-369
Range on HMM: 30-289/297.0
ESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQ
 . |  .. .. |||||.    . ||  ||||.|| . . |||.||..||   ...|.| ||||...||. .|||||....  ||| |.. .  .. | |
veGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgq

YWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQevtdERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGNIIKDED-----DMR-GP
|||.. |  ...||. .. |  |.  ....|.. ........    .| .  | .. |  .  | | ..||.... ||   . ..|.       ...  |
yWpleeessaefgdlsvsnveveeeedykvrvleiknvktee....srkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPP

ILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEH
|.|||| | ||.| ....| .|.  ||..  .|.  .|.||. |   .   |||.| | .. |.
ivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
0036941 (Phosphotyrosine protein) phosphatases II 399-679 1.4e-57 190.6 In-house 13-282 (297) alignment 
Range on Protein: 399-679
Range on HMM: 13-282/297.0
NEYQAEYDQIckqTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLtsfqGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSA
. .. |....   .|.. .|..  ... .|.||||   ..| |. | .|    ..  .||||  .||||  .|..|.|..|...|...|| .|..| .. 
alllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

VVVLCQPPS-QSQQYPSFWPNK-SKMEKYGPvFSVHYVMSKS--YTNIKQWEFKINKKIVSltemmagvkaPTRTVQLFQLTCWPmGHKVPSSTNSLVYL
.|.|... . . ......||..  .  .||. |.|...  ..  ........... ..  .          ..|||. |. | ||  |.||.|..||. .
Ivmltelvelgrekcaqywpleegesltygd.ftvtllsvevvllddytlrtlevtdtgng..........esrtvthfhytgwp.dhgvpespaslldf

MNMVEIWRNKV-DYGPVCVVSPDGRSRAGVYCAANACIEQVI---QHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFLN
...|. ....  . |||.| . .| .|.|...||  ...|.     .|.||...|||..|..||. |..   |...|...|......|.
ielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 82-380 7.6e-57 187.7 In-house 9-294 (297) alignment 
Range on Protein: 82-380
Range on HMM: 9-294/297.0
PIDIRHFLKLCDLRRKFPVLYKlEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKpnAYIVTQGPVEETV
|| . .|  | .  |.  | .. ||.   . .  .   | || |.||..    .||| .|| |. |.   ||||||||.| .  .   .| || | ..||
piplsdfatlvqknrhtdvfse.eflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatv

QAYWRMVWQENISAIVMLTKTFDFAKvMCHQYWPPNMEVHeqYGDIFINIVREEQLANFHIRTFRLYKMNEKQevtdERLILQFHYTEWYSHSCPF---S
. .|.||..|..|.||||..  .  |  | .||. .  .   .||. . .   ..   |  |.. . | . |.    .|.. |....|| ... .     
adfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkaka....rrvvkqyqfveWPdkaverkdsa

NALLEFRRRVRLVVgniikdEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFP
..||..   || .       ..   ||.||||. | || ||...||  .  |..|.  ..||..|||||.|  ||   |||||.| .. | ... .|  .
ssllklisevrkdf......sqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriq

VS
.|
as
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 104-406 8.1e-57 187.8 In-house 27-324 (325) alignment 
Range on Protein: 104-406
Range on HMM: 27-324/325.0
LEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMV--WQeniSAIVMLTK
 ||.    ... . . | | .| .||. .  ...| .|||||  .   .|||.||||. .  | . .. .| |  .|..  ||.|  |.   ...|... 
hefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr...csvvvvln

TFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNeKQEvtdERLILQFHYTEWYSHSCP-FSNALLEFRRRVRLVvGNIIKDED
 .|  |  | .||| .|    ..| . ....  |.....  | . . ... | |    | . ||..  |     . .  .|. . . |  |  . .. . 
eldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk.kGe...trsvkqfqlqswddmGvqkrpatlisilqlvkav.servtant

DMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNE
   .|||||||.| ||.||..|. . |.   ||   ..||..||||. |  .|| |.|| .||..| | ...|.|  ||| .  .| .   ||  |.  .
kastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpltqkln

YQAEYD
 . |..
iekefe
subfamily_PTPN3_pd Subfamily PTPN3 111-365 1.9e-56 186.1 In-house 27-270 (280) alignment 
Range on Protein: 111-365
Range on HMM: 27-270/280.0
KVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKvgglQDSDYVNASYVDSLLKP----NAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFA
| .. .. .| | .||.||.    .|||  || |..    ...||.||.||.  .      | ||.||||...|.. .|.|||....| ||||| . .  
kkpglaisaarkpenlsknryrdilpydatrvklke....setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverG

KVMCHQYWPPNMEvHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKqevtDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVgniikdeDDMRGP
.| |||||| . . . .||.. ... .|..  .. .| . | . ..|    .|| |||. |..|  |. | . . .||| .||| .          .. |
rvkChqyWPeted.eleygefsvkcekedetksyvlrelvlkdketk....eerkilqlqylaWpdhgvPddsadflefvervrklr.......sgkeeP

ILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDT
..|||| | ||.||.. ..  | | |..| ...   ....|. |. ||....||||. ..
vvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea
0045450 (Phosphotyrosine protein) phosphatases II 397-674 3.8e-56 186.4 In-house 25-304 (307) alignment 
Range on Protein: 397-674
Range on HMM: 25-304/307.0
KMNEYQAEYDQICKQTPRFtIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGN-AFTDYINSVFV--------DGYTKPREYIVTEWPMKHTLGEF
 .. ...|. .....|... .|..  ...  |..||| . ..| |. | .|.| .|.   .||||  .|        ||| ..|..|.| .|...|. .|
fltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WSLVYDQECSAVVVLCQPPSQ-SQQYPSFWPNKSKMEKYGPvFSVHYVMSKSYTNIKQWEFKINKKivsltemmaGVKAPTRTVQLFQLTCWPmGHKVPS
| ....| ....| |...    ..... .||...    ||. | |...  . . ... . ...  .         . . ..|||. |. |.|| .|.||.
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygn.ftvtllseehldgytvrtlevtdl.........dgtgesrtvthfhytgwp.dhgvpp

STNSLVYLMNMVEIWRNKV-DYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGE---VDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
|...|. ....|. ....  . |||.| . .| .|.|...||  ...|. ..|.   ||...|||..|..||. |.|   |...|...|...
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 401-674 4.3e-56 185.8 In-house 22-277 (278) alignment 
Range on Protein: 401-674
Range on HMM: 22-277/278.0
YQAEYDQICKQTPrftiGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVV
...|. .......    ...  ... .|..||| . ..| |. | .|....|   .||||  .|||| .||..|.| .|...|.. || .|... .. .|
lllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttiv

VLCQPPSQS-QQYPSFWPnkSKMEKYGPvFSVHYVMSKSYTNIKQWEFKINKkivsltemmaGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVE
.|...   . ...  .||  .....||. |.|...  ... ..... ... .            . ..|||. .. ..||  |.||.|...|. ....| 
mLtelvelgrvkcaqYwp..ggsltygd.ftvtllkeehlddytvrtlevtn..........lgdgesrtvthyhylgwp.dhgvpeslsllldflkavr

IWRNkVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
 ...  . |||.| . .| .|.|...|.  ..||.  .|.||...|||..|..||. |..   |...|...|.|.
eale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 395-674 8.6e-56 184.8 In-house 8-272 (273) alignment 
Range on Protein: 395-674
Range on HMM: 8-272/273.0
GTKMNEYQAEYDQICKQTPrftIGDCAGGHRADNREKNRDVLCVPPDNFRPYLtsfqGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQ
 . .. ...|........|   ....  . . .|..|||   ..| |. | .|    |.  .||||  .|||| ..|..|.|..|...|...|| .|..|
llgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

ECSAVVVLCQPPSQ-SQQYPSFWPNKSK--MEKYGPvFSVHYVMSKSYTNIKQWEFKINK-KivsltemmagvKAPTRTVQLFQLTCWPmGHKVPSSTNS
 .. .|.|... .   .... .||..    ...||. |.|...  ... ......... . .              .|||. |. | ||  |.||.|..|
nvrviVmLtelvelgrekcaqYwpleggelsltygk.ftvtllseetkddytvrtleltnlg...........tgesrtvthfhytgwp.dhgvppsles

LVYLMNMVEIWRNKV-DYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
|. ....|. ..... . |||.| . .| .|.|...|.  ...|.. .|.|||..||| .|..||  |..   |...|...|.|.
llefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 114-376 9.2e-56 183.9 In-house 36-284 (287) alignment 
Range on Protein: 114-376
Range on HMM: 36-284/287.0
SNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEkvggLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQY
 .   |.. ..| .||.  . ...| .||.|.     .. ||.||...|.  . .|.|....|. .|.. .|......|..|||||..  .  . .|.||
edevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqy

WPPNMEvhEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQevtDERLILQFHYTEWYSHS--CPFSNALLEFRRRVRlvvgniiKDEDDMRGPILVHCS
|| .      .|.  |... ||. |.. .|.... . |...   |.. . |...|.| |.     .   || . ....       ..    ...|.||||
Wpeeks..vvlGeyniellneevnagyierklevknknkag...dkqqvkqyqitnWdstgkvtepqtillvieemyk.......tqrkrgntsivvhCs

DGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTW
|. |||.......  .. ...|   .||  ||. |. . | |  |||||||.| . |.. ...| 
dtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
0040438 (Phosphotyrosine protein) phosphatases II 409-679 4.6e-55 182.5 In-house 24-281 (317) alignment 
Range on Protein: 409-679
Range on HMM: 24-281/317.0
CKQTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQ
 .. ..... ..  ... .|..||| . ..| |. | .|....|   .||||  .|||. ..|..|.|  |...|.. || .|..| .. .| |...   
fedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleel

-SQQYPSFWPNkSKMEKYGPvFSVHYVMSKSYTNIKQWEFKINKKivsltemmagVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRNkVDY
  ...  .||.  .  .||. |.|...  . . .|. ..... ..           . ..|||. |. | ||  |.||.|...|. ....|. ...  . 
grekcaqYwpl.getltygd.ftvtllseeelagitlrtlevedl..........gdsesrtvthfhytgWp.dhgvppspdllldfleavreale.dpg

GPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFLN
|||.| . .| .|.|...||  ..||. ..|.|||..|||..|..||. |..   |...||..|.|....|.
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 384-677 7.3e-55 181.3 In-house 12-293 (298) alignment 
Range on Protein: 384-677
Range on HMM: 12-293/298.0
DRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHT
  |.  |  .  .|.  |..|. .. . . .        ... .|..|||    .. |  |  |.. ...  .|||| .|...|..   .|.|. |...|
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltet

LGEFWSLVYDQECSAVVVLCQPPSQSQ-QYPSFWPNKsKMEKYGPVfSVHYVMSKSYTNIKQWEFKINKKivsltemmagVKAPTRTVQLFQLTCWPmGH
. .|| .| ... ...|.| .   . . .|. .||.. . |.|| . .|.   ....... . ..|..||           .. .|.|. .. | ||  .
vedFWrmvteedigtiVmltnleeldktkyhkywPde.gketygei.tvsllskeefadlivrklkvskk..........keekerevrqlhftsWp.dk

KVPSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHF
 ||. ..|.. |.. |. ....    || |   .|  |.| ..| .. .|.| .   |||||.||..|..||..|.  ..|...|..||...  |
gvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
DSPc_SM00195 402-674 2.8e-54 179.5 In-house 3-262 (263) alignment 
Range on Protein: 402-674
Range on HMM: 3-262/263.0
QAEYDQICKQTPRFtigDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVV
..|.... ..|.     ..  ...  |..|||   ..| |. |  |.. ...  .||||  ...|..|...||.| .|...|. .|| .|...... .|.
keefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LCQPPS-QSQQYPSFWPNKS-KMEKYGpVFSVHYVMSKSYT-NIKQWEFKINKKIVsltemmagvkAPTRTVQLFQLTCWPMGhKVPSSTNSLVYLMNMV
|...   ....  ..||..| . |..|  .||. |  ...  .|.. .....|.              ||.|. .| . ||   .||.||.|.. |...|
lteeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegk..........eetrkvtqyqyknWpdh.gvpdstksvlellrav

EIWRNKVdYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
. ....   ||..|.. .| .|.|...... ..... .. .||.|. || .| .||..|.. ..|...|. .|.|.
kksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 402-674 2.8e-54 179.5 In-house 3-262 (263) alignment 
Range on Protein: 402-674
Range on HMM: 3-262/263.0
QAEYDQICKQTPRFtigDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVV
..|.... ..|.     ..  ...  |..|||   ..| |. |  |.. ...  .||||  ...|..|...||.| .|...|. .|| .|...... .|.
keefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

LCQPPS-QSQQYPSFWPNKS-KMEKYGpVFSVHYVMSKSYT-NIKQWEFKINKKIVsltemmagvkAPTRTVQLFQLTCWPMGhKVPSSTNSLVYLMNMV
|...   ....  ..||..| . |..|  .||. |  ...  .|.. .....|.              ||.|. .| . ||   .||.||.|.. |...|
lteeeengkekcdrywpeesggketfg.kisvklvevekkkdeiilrtleltkegk..........eetrkvtqyqyknWpdh.gvpdstksvlellrav

EIWRNKVdYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
. ....   ||..|.. .| .|.|...... ..... .. .||.|. || .| .||..|.. ..|...|. .|.|.
kksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
Y_phosphatase Protein-tyrosine phosphatase 428-671 1.1e-53 177.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 428-671
Range on HMM: 1-234/235.0
NREKNRDVLCVPPDNFRPYLTSFQGNAFtdYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPS-QSQQYPSFWP-NKSKMEKY
|..|||   ..| |. |  |.. .|.    |||  .|.||......|.|. |.|.|...|| .|........|.|..    ...... .|| .......|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPvFSVHYVmsksyTNIKQWEFKINKKIVSLTE----MmagvkaPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRnKVDYGPVCVVSPDGRSRA
|  ..|...     ...|..| ... . ..|..            .|.|. ...| ||  |.||.|..||. |...|| .. . . |||.|.. .| .|.
gd.ikvelk.....ekekedekeytlrklelkkkkees......ekrevkqlhytnWp.dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRt

GVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVL
|...|.....||. ...||||.|.||..|..||..|.....|...|...|
gtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 428-671 1.1e-53 177.5 In-house 1-234 (235) alignment 
Range on Protein: 428-671
Range on HMM: 1-234/235.0
NREKNRDVLCVPPDNFRPYLTSFQGNAFtdYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPS-QSQQYPSFWP-NKSKMEKY
|..|||   ..| |. |  |.. .|.    |||  .|.||......|.|. |.|.|...|| .|........|.|..    ...... .|| .......|
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GPvFSVHYVmsksyTNIKQWEFKINKKIVSLTE----MmagvkaPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRnKVDYGPVCVVSPDGRSRA
|  ..|...     ...|..| ... . ..|..            .|.|. ...| ||  |.||.|..||. |...|| .. . . |||.|.. .| .|.
gd.ikvelk.....ekekedekeytlrklelkkkkees......ekrevkqlhytnWp.dhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRt

GVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVL
|...|.....||. ...||||.|.||..|..||..|.....|...|...|
gtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 105-375 2.3e-53 175.8 In-house 20-298 (301) alignment 
Range on Protein: 105-375
Range on HMM: 20-298/301.0
EFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGG--LQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKT
....  ..|...|   |...| . |.. .  .|| ||..|..     |.  .|.||||.|.  . ...|..|||...|.. .||..|||  ..|||.|..
qykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnl

FDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRL-----------YKMNEKQEVTDERLILQFHYTEWYSHSCpfsnaLLEFRRRVRLV
 . .|  |.||||   . .|..| . . .| |  . .| || . .            .. ....  . . .||.. |.|  .       . | |  .. .
kegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGv.....vreprtvLqvi

VGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKT
   |..      ||..|||||. .|||||.|..  || .  |   .||.  | .|.|. | |   ||| .||| ... . . .|
ddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnst
subfamily_PTPRD_pd Subfamily PTPRD 402-676 4.9e-53 175.6 In-house 26-283 (564) alignment 
Range on Protein: 402-676
Range on HMM: 26-283/564.0
QAEYDQICKQtPRFTIGDCAGGHradNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVV
. || .| .. ..||.  ..  .   |..|||    |. |. |  |....|.  .||||  |.|||.|...|| |  |...|. .|| .|..|..| .| 
eeeykkieeg.qqftweaankpa...NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVm

LCQPPSQSQ-QYPSFWPNKSkMEKYGPVfSVHYVMSKSYTNIKQWEFKINKKIvsltemmagvKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEI
| .   ... .. ..||.|.  |.|| .  |  . .. ....   .||..||           .  .|.|. |. | ||  | || |..||. |.. |. 
ltkleEkgkvkchkYWPekg.tetygel.tVtleeeeeladyeirtfklkkkk..........ssesreVrqFhFtsWP.dhgvpesatslLdlirkvra

WRnKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLH
.. . | ||. |    |  | |.... .|..|.. . . ||..| ||..|..|. .|.. . | .... .|...  
ln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 103-385 5e-53 175.1 In-house 23-294 (439) alignment 
Range on Protein: 103-385
Range on HMM: 23-294/439.0
KLEFQTAAKVESN-TCRHALKKNNL--EKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVML
| .|..   .. . .|  .|  ..    ||.  .  ..|. ||.|... |.  | |.|| |..   ... || |||| .||.. .||.|.... . ||||
keifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml

TKTFDFAKvmchqYWPPNMEVHeqYGDIFINIVREEQLANFHIRTFRLYkmNEKQEVTDERLILQFHYTEWYSHSCPFSN-ALLEFRRRVrlvvgNIIKD
|. ..  |     ||| . ||   |||| . . |. .| |. || |...  ||..    || .|||||. |  .  |     .|.| | .     |  .|
tnlvesyk.....ywpsdaevc..ygdiavrvdrnielpnyvirgfkvf..nerdttekertvlqfhyiawpdknvpaqashvldflrai.....nsand

EDDmRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVSELSDR
...  ||..|||| | ||.|  ...|  ||    |.  .. | .| ||. || .|... || |||... | |. |..   . |.  .
kee.ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkke
subfamily_PTPRK_pd Subfamily PTPRK 424-673 7.6e-53 174.4 In-house 39-276 (314) alignment 
Range on Protein: 424-673
Range on HMM: 39-276/314.0
HRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQS-QQYPSFWPNKSKM
.. .||||||    ...|. |. |.. .|.. .||||. ..|.|..|...|||  |...|. .|| ||||..|...|.| .  ...  .   .||.....
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev

ekYGPVfSVHYVMSKSYTNIKQWEFKINKkivsltemMAGVKAPTRTVQLFQLTCWPMgHKVPSSTNSLVYLMNMVEIWRNKvDYGPVCVVSPDGRSRAG
  ||..  |..| ..  ... .  |...|        .|  .  .|.|. || . ||. |.|| | ..|. |.  |. .... . |.. |    |  |.|
..ygdi.kvelvetellaelvvrifrvek........largqeeirevrqfqflgWpd.hdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtG

VYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHY
...| .  .. . ..| ||||.||||.| ... .|| .  ||..|| .|  
tfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea
0040439 (Phosphotyrosine protein) phosphatases II 419-675 2.6e-52 173.3 In-house 2-247 (249) alignment 
Range on Protein: 419-675
Range on HMM: 2-247/249.0
DCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQ-SQQYPSFWP
..  ...  |..||| . ..|.|. |..|....|   .||||  ..|||  .|..|.| .|...|.. || ..... ....| |...     ...  .||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NkSKMEKYGPvFSVHYVMSKSYTNIKQWEFKINKKivsltemmagVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRNKV-DYGPVCVVSPD
. ... .||  |.|...  ... ......... ..           . ..|||. .| | ||  |.||.|...|. ....|. ....  . |||.| . .
l.ggsleygd.ftvtllsvevkddytvrtleltnl..........ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsa

GRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVL
| .|.|...||  ..||.  ...||...|||..|..||. |.|   |...|...|...|
GvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_PTPN14_pd Subfamily PTPN14 109-368 8.8e-52 170.9 In-house 33-294 (300) alignment 
Range on Protein: 109-368
Range on HMM: 33-294/300.0
AAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLqDSDYVNASYVDSLL--KPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFA
. | |  ..  |  ..| |||. .. .||. ||| |       ...|.||| .   .  |   |||.|||.| ||| .|.|||..... |||||.. .  
pkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedg

KVMCHQYWPPNMEV--HEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQevtdERLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGNIIKDE--DD
|  ...|.| . .   . ..|   .     |.   .  ....|. .  |.    || .. . ||.|  | .|   .  |.. ..|. |  .  .     .
keksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske....ertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveske

MRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEE
.. |.|||||.|.||.|| .  |  ..  | .|  ..   |..||. |  ||... ||||.|..| .
skPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 125-366 5.9e-51 168.0 In-house 3-235 (237) alignment 
Range on Protein: 125-366
Range on HMM: 3-235/237.0
NLEKNQNPKCIPYDYNRVVLEKVGGLqdSDYVNASYVDSLL-KPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPpNMEVHEQ
|  ||.  . . ||..||||.  |.   |||.||.|....   |. || .|||.| . . .|.|||||. | |||||   .  .. ||.||| . .  . 
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaa

YGDIFINIVREEQLANFHIRTFRLYKMNEKQEVtdeRLILQFHYTEWYSHSCPF-SNALLEFRRrvrlvvgNIIKDEDD--MRGPILVHCSDGGGRSGVY
|| . . . ..|..... .|.. | |  ...||   ||| |...| |  .  |  . ||| ||.       |||.        || ..||| | ||.|..
ygvltvslkkkeefsdytvrslllskrltlkev...rlihqyqftswpdrgvpqqtaallrfrk.......niinrsphvsesgpwiihcsagvgrtgif

MSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL
. ||| |  |.|..  ... |.. . . |  ...  .|| ||..|.
lvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_PTPN13_pd Subfamily PTPN13 111-365 1.1e-50 167.5 In-house 22-264 (273) alignment 
Range on Protein: 111-365
Range on HMM: 22-264/273.0
KVE-SNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGlqdsdYVNASYVDSLLKPNA--YIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAK
..   .||. . ||.| .||.  . .|||  || |.. ||     |.|||..   .  .   ||..|||. |||. .|.|||. . . |.|.|.  .  |
elkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgk

VMCHQYWPPNMEVHEQYGD-IFINIVREEQLANFHIRTFRLYKMnekqEVTDERLILQFHYTEWYSHSCPFSN-ALLEFRRRVRLVvgniiKDeddMRGP
| ||.||| ... . .  . . .. .. ..| .| .|.. . ..    | .. | . ......|  |. | |   ||.| ..|| .     ..    .||
vkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds....esgesrevahlnfvkwPdhgvPssaaellqfvaevrrl.....qt...dagP

ILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDT
|.|||| | ||||....||. |.| | .. |.|   ..|||. |.|.|   .|| |.| .
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyka
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 125-369 1.2e-50 167.2 In-house 28-267 (274) alignment 
Range on Protein: 125-369
Range on HMM: 28-267/274.0
NLEKNQNPKCIPYDYNRVVLEKVG-GLQDSDYVNASYVDSL-LKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNM--EV
. .||.  . .| .  ||.||.     .||.|.|| |.     . .||. ||||. .||. .|||..||... ||||||  .  .  |..|.| .   |.
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

HEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEvtderlILQFHYTEWYSHSCPFS-NALLEFRRRVrlvvgNIIKDEDDMR-GPILVHCSDGGGRSG
.|.|||. |...   .  ....|.. | .......      .  . ||.|  |  | . |.||.. . |     .  ..|.... .|..|||| | || |
serygdveikvekiverndysvrklvlkylerers......vkhywytdWPdhksPddantlldlvlev.....eesreeenaklapvvvhCsaGiGrtG

VYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEH
....|.  .   .||.  .|..   .||. | |.|.. |||..|. .| ..
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_PTPN1_pd Subfamily PTPN1 106-368 8.4e-50 164.1 In-house 15-269 (290) alignment 
Range on Protein: 106-368
Range on HMM: 15-269/290.0
FQTAAKveSNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKvgglQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDF
 .  |.    ..|.| ...| ..|.     |||. |..||.    .| ||.||| |.       ||.||||. .||. .|.|||...  |.||| |  . 
irkeas..dfptreaklpenrnlnryrdvspydhsrikler....adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvek

AKVMCHQYWPPNMEVHE---QYGDIFINIVREEQLANFHIRTFRLYKmnekQEVTDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLvVGNIIKDedd
 .. |.|||| . |..|   .   . .....||.  .. .|...| .    ..  . | ||.|||| |   . | | .|.|.|  .||   | . .|   
eqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen....lktqetreilhfhyttwpdfgvpespaaflkflfkvre.sGslssd...

mRGPILVHCSDGGGRSGVYMSIDANLELAEEEE---CFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEE
  || ..||| | |||| .. .|. | | |...   . ..   | .||. | ||.   .| .| | .. |
.vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
0042113 (Phosphotyrosine protein) phosphatases II 424-674 3.2e-49 162.9 In-house 5-243 (245) alignment 
Range on Protein: 424-674
Range on HMM: 5-243/245.0
HRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQS-QQYPSFWPNkSKM
 .  |..||| . ..| |. | .|.. .|. ..||||  .||||  .. .|.| .|...|.. || ..... ....| |...   . .... .||. . .
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ges

EKYGPvFSVHYVMSKSYTNIKQWEFKINKKivsltemmagVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAG
 .||  |.|...  ... ......... ..           . ..|.|. .. . || .|.||.....|. ....|. .... . |||.| . .|..|.|
ltygd.ftvtllseehlddytvrtlevtnl..........gddesrevihyhylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtG

VYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
...||  ..||.  ...|....||| .|..||. |..   |...|...|...
tfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 116-378 3.4e-49 162.2 In-house 24-274 (283) alignment 
Range on Protein: 116-378
Range on HMM: 24-274/283.0
TCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGlqdsDYVNASYVD---SLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQ
 .  |  ..| .||.| . .|.| .|| |.        ||.||...    |  . . ||..|.|...||. .|.||..|.|.|||||||  .  .. | |
dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPPnmEVHEQYGDIFINIVREEQLANFHIRTFRLYKMnekQEVTDERLILQFHYTEWYSHS-CPFSNALLEFRrrvrLVVGNiikDEDDMRGPILVHCS
|||   .  |.||.  . . .|     | |. . | .        .. |.  . . .| . .  .  |.|. |     .|. .     .  .|||.||||
yWPk..rGsedyGeftvtlrkettsnsfiikelllrvn...ssakstlllahyqvidWleygeqaiinslvkfn....kvisl...qteskkgPivvhCs

DGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFP
 |.||..|.... | .. |  |   .||  .| .|. | ..| . .|||....   |. .|| |   
tgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 120-364 5.4e-49 161.5 In-house 3-235 (239) alignment 
Range on Protein: 120-364
Range on HMM: 3-235/239.0
ALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYV-DSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPpnm
| |. |  ||.  . . ||..||||||.     |||.||||. |    |.||| ||| || .   .|||.|||    |||||   .  |  ||||||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...

EVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEkqevTDERLILQFHYTEWYSHSCP-FSNALLEFRRRvrlvvgnIIKDEDDMRGPILVHCSDGGGRS
.   .| .. . . . | .|.. |||| . .. .    |.|| . |.|.| |  .  | .. |.| .||.       | ||      | ..||| | ||.
dstskycnlrvtlrktevfadyiirtfvmsqvgq....teeryvyqyhftvwpdkgvpqyatavlglrrk.......itkdslpgarpwvihcsagvgrt

GVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYD
| .. ||| |  |....  ..| |.| .|. |  .|.  ||| ||. 
gaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 121-364 5.7e-49 161.4 In-house 3-234 (239) alignment 
Range on Protein: 121-364
Range on HMM: 3-234/239.0
LKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYV-DSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPpnmE
 |. |  ||.  . . ||..||||||.     |||.||||. |    |.||| ||| || .   .|||.|||    |||||   .  |  ||||||   .
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...d

VHEQYGDIFINIVREEQLANFHIRTFRLYKMNEkqevTDERLILQFHYTEWYSHSCP-FSNALLEFRRRvrlvvgnIIKDEDDMRGPILVHCSDGGGRSG
   .| .. . . . | .|.. |||| . .. .    |.|| . |.|.| |  .  | .. |.| .||.       | ||      | ..||| | ||.|
stskycnlrvtlrktevfadyiirtfvmsqvgq....teeryvyqyhftvwpdkgvpqyatavlglrrk.......itkdslpgarpwvihcsagvgrtg

VYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYD
 .. ||| |  |....  ..| |.| .|. |  .|.  ||| ||. 
aflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_PTPRN_pd Subfamily PTPRN 110-368 1.6e-48 160.0 In-house 41-290 (297) alignment 
Range on Protein: 110-368
Range on HMM: 41-290/297.0
AKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYV-DSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKV
 . | .|.  | ...|..||.. ...||| .|| |..    ..|||.||| . |.  .  ||| ||||. .|| ..|.|||.. .  ||.||.  .    
yeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvk

MCHQYWPPnmEVHEQYGDIFINIVREEQLA-NFHIRTFRLYKMNEKQevtdERLILQFHYTEWYSHSCPFS-NALLEFRRRVRlvvgniiKDEDDMRGPI
 |..|||   | .| |.   ...| |   . .. .|.| |  .. ..     | . |||.  |.....| | ..||||||.|        |       ||
qckrywpd..eGsevyhiyevhlvsehiwcddylvrsfylknlqtse....trtvtqfhflswpeegvPasaksllefrrkvn.......ksyrGrscpi

LVHCSDGGGRSGVYMSIDANLE-LAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEE
.|||||| ||.|||. ||  |. |.      ..   |..||. |.|||.  .|..|.. .. |
vvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 391-674 4.9e-48 158.8 In-house 14-283 (305) alignment 
Range on Protein: 391-674
Range on HMM: 14-283/305.0
RRNSGTKMNEYQAEYDQICKQTPRFTIGdcaggHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSL
. .. .. ....|.|......   . .|     ..  |..||| .  .. |. |  ||  . .  .||||. .|||| .  .|||.  |.|.|. .|| |
kearvysdkgleaqykslyeeeesidvg.....kkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrl

VYDQECSAVVVLCQ-PPSQSQQYPSFWPNKSKM-EKYGPvFSVHYVMSKSYTNIKQWEFKINKKIVsltemmagvKAPTRTVQLFQLTCWPmGHKVPSST
...   | .| |..    . ..   .||.. .  ...|. |||.   .|....  . ..|| ..           .  .|||  .||| ||  | || ..
iveekvstivmltklveggkdkCrqYWpesktekkefge.fsvelksektasdyieRklkisiede.........dkesrtvlqyqltdWP.dhGvpqfa

NSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
 ||. |.. |.  ..|    |. |.  .| .|.||..| .  .|.. . ..||||. .|..|..|...|... .| ...| .  ..
tsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 129-370 1.8e-47 156.6 In-house 24-264 (270) alignment 
Range on Protein: 129-370
Range on HMM: 24-264/270.0
NQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVD-SLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDI
|     .|    ||.||..   . . |.|| ||     ....|| ..||.. |....|||.|.|. .||||.|.  .  .  | .|||.. . . .. | 
nRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledg

FINIVREE-QLANFHIRTfrlyKMNEKQEVTDERLIlQFHYTEWYSHSCPFSNALLEFRRRVRLVVGNII--KDEDDMRGPILVHCSDGGGRSGVYMSID
.|... .. . ....|.|    ... ... . .||.  |.|..|  |. | ..      . .  .. ..   ..| |  .|.|||||.| ||.|. . .|
kikvlalseekeegyilt....rlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

ANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHI
  ..| ||..  .|   ...||. |  ||. .|||.|.| .. |..
iavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 82-392 1.1e-46 154.1 In-house 3-258 (392) alignment 
Range on Protein: 82-392
Range on HMM: 3-258/392.0
PIDIRHFLKLCDLRRkFPVLYKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETV
|| . .|  . .  | .  |.  ||.     .    . | |. ||.||.  . .||| .||.|| .    ||||.||||..|.   .||| .|||   ..
pipvaqfpafveknr.hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasl

QAYWRMVWQENISAIVMLTKTFDFAkvmchqywppnmevheqygdifinivreeqlanfhirtfrlykmnekqEVTDERLILQFHYTEWYSHSCP-FSNA
. .||||.|||...|.|.||  .                                                     | | . |||.|||  .  | ....
ddfwrmvfqenvttiamvtklkegd................................................kgddartvaqfhftewPdkdvpkhtss

LLEFRRRVRLVVGNIIKdeddmrgPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWFPVS
||.| . |.   |.  .       |...||| | ||.|| .|||. .  |..    .|| .. ..|. |  .|.  ||| ||| .. | ..  .|  || 
llkfikevkadfGqyth.......pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvv

ELSDRLKAKARR
 ..|.|.     
hftdhlqdlsts
subfamily_PTPN23_pd Subfamily PTPN23 105-366 1.1e-46 154.0 In-house 23-276 (288) alignment 
Range on Protein: 105-366
Range on HMM: 23-276/288.0
EFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEkvggLQDSDYVNASYVDSLLK-PNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTF
|.... . |..    |. | . |||..  ..||| |||.|.     .  ||.|||.| .|      .|.||.| ..|.. .|.||...  | ||||..  
eleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllske

DFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLyKMNEKQEVTDERLIlqfHYTEWYSHSCPFS-NALLEFRRRVRLVVGniiKDEDDM
.  |  ...||| . .  ...||. . . ..... ..  |...| .......| . ...   ..|.| ..  | | . ||.|   |.       . .  .
elgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkl.etldadavksvshl...qltsWpelGvPasPetllqfldevesaye...avqrks

RGPILVHCSDGGGRSGVYMSI-DANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL
. |..|||| | ||.||.  .  |  || ...   ..   ...||. |.  |...||.|| |.  
ktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeav
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 401-677 5.6e-46 152.0 In-house 22-283 (318) alignment 
Range on Protein: 401-677
Range on HMM: 22-283/318.0
YQAEYDQICKQTPRFTIGDCaggHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVV
...||... ...  .|  .        |. ||| .  .. |. |  |. ..|.  .||||. ..|||.. ..|| .  |. .|. .|| .|..|... .|
lseeyerlsrseetvtslks...lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsaviv

VLCQPPSQSQ-QYPSFWPNKSKmEKYGPVfSVHYVMSKSYTNIKQWEFKINKkivslTEmmagvKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVE
.| |   ... .   .||.|   ..|| .  |.   ......    |||...     ||     .  .|.|. .. | ||  . ||.|. ||. |.  |.
mltqeeergkakvhryWPskgs.rsygkl.vvelkeevelsdyvlrefkvtr.....te.....eeesrqvrqyhytsWp.degvpesgaslldlvrqvs

IWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHF
 . .| ..||. |    |  |.||..| .. .|.. . . ||||| ||..|..|. .|     |...|| .| ..  .
kaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
subfamily_PTPRG_pd Subfamily PTPRG 400-674 8.6e-46 151.3 In-house 20-287 (563) alignment 
Range on Protein: 400-674
Range on HMM: 20-287/563.0
EYQAEYDQICKQTPRFTIgDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFT-DYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSA
 ...|.... ..|   .. |.   .. .|..|||..  |. |. |  |..  |.  . ||||  ..||| | ...|.|  |.|.|.  || ....|. . 
gfseefealqsetiskdl.daehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

VVVLCQ-PPSQSQQYPSFWPNkSKMEKYGpVFSVHYVMSKSYTNIKQWEFKINKKIVSLTEMmagvKAPTRTVQLFQLTCWPmGHKVPSST-NSLVYLMN
.|.. .   .. .. . .||.  . |.|| ...|  . ..  .   . ...|.. ..  ..     .   ..|. .. | ||  | ||...   | .   
ivmitnlvergrrkcdvYWPk.desetyg.alqvtlieeevlalytvrtlviknlklkkkkq....cdteklvrqyhytkWP.dhgvPehslpvLifvkk

MveIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
      || . ||. |    | .|.|.|.. .. ..|. |.  |.||. .|..| .|. ||..  .| . .| .|  .
s..saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 424-676 2.1e-45 149.9 In-house 5-244 (250) alignment 
Range on Protein: 424-676
Range on HMM: 5-244/250.0
HRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQYPSFWPNKsKME
.. .|.||||.   .. |. |  | . .|.  .||||..|..||.. . .|.|  |...|. .|| .|.... ...|.| .   . ..|. .|| . | |
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPve.kae

KYGPVfSVHYVMSKSYTNIKQWEFKINKKivsltemmagVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGV
||| |  |.   .. ...... ..|. |.           ||  |.|. .. . ||    ||  ... . |.. |.  ..... .|| |    | .|.| 
kyGdv.tvsllskeefadytkrklklska..........kkaderivrqlhfvvWP.dkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGa

YCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLH
..| .| .|.. .   ||||. .|..|..||. ||  . | ..| ..|...  
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 403-677 4.1e-45 149.2 In-house 27-286 (319) alignment 
Range on Protein: 403-677
Range on HMM: 27-286/319.0
AEYDQICKQTPRftigDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVL
 |. .. . ..     .    .. .|..|||    .. |. |  |....|   .||||. |.||| . ...| |  |...|. .|| .|...|.| ||.|
kefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvml

CQPPSQSQQYPSFWPNKSKMEKYGPVFsVHYVMSKSYTNIKQWEFKINKKIvslTEMMAgvkaptRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWR
..   . .   .  ... ..|.|| .  |     .   ..   ..|.|||    .|. .      |.|. || | ||  |.|| .. ||. |.. ..  |
tklveklkvklkkywpeenfeeyGrli.vtleeeeeledyiirklklnkks...sevet......RevkhfqyteWp.dhdvPekatslldllkrirksr

NKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHF
.| . ||. |   .|  | | ... .| .|.| . | .|||. |...|  |. .|..   ||..|. .|..|  .
ektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 400-677 6.3e-44 145.0 In-house 21-286 (290) alignment 
Range on Protein: 400-677
Range on HMM: 21-286/290.0
EYQAEYDQICKQTPRFTIgdcAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGN--AFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECS
 ..... .. .    .|.     |   .|...||   .|..|..|  |   .|.     .||| ....|| . ..||.|. |...|| .||.|.......
gfrnqfkmldsgesehtv...tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvt

AVVVLCQPPSQSQ-QYPSFWPNKSKMEkYGPvFSVHYvmsksytnikQWEFKIN---KKIVSLTEMMAGvkAPTRTVQLFQLTCWPMGHKVPSSTNSLVY
..|.|..  .. . .   .||...  . ||. ||..           . | ..|   .. ...... ..  .....|. .|.|.|.   ||.  . .|. 
iivmltniieegkvkCqqYWpdsdtka.yge.fsikl..........lneetlneyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillv

LMNMVEIWRNKVdYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHF
. .|... | .   ... |   |. .|..|.|||.  |... . | .|||| .|. |  .|..|. . .|.. ...||.|. .|
ieemyktqrkrg.ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 389-672 7.4e-44 144.9 In-house 11-277 (288) alignment 
Range on Protein: 389-672
Range on HMM: 11-277/288.0
KARRNSGTKMNEYQAEYDQIckqTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFW
|. . | .. .... ||...   ..     .   |..| | .|||    .| |  |  |.  . .| .||||. ..||. | ..|| |  |. .|...||
kvakksarnrtgfseeynsL...aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

SLVYDQECSAVVVLCQP-PSQSQQYPSFWPNKSKMEKYGPVfSVHYVMSKSYTNIKQWEFKINkkivsltemmagVKAPTRTVQLFQLTCWPmGHKVPSS
 |||... | .| | .    . ..   .||.. | ..|| |  |  | ||  ... . .. ..             |   .... .| . ||  |.|| |
elvyenktstivmltelveggktkCeeYWPdadkpknyGsv.tvtlveskeledfvlrkllle............kkkteleitqyqylaWp.dhgvPes

TNSLVYLMNMVEIwRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLH
.. |. |...|..  |. | ||. |.  .|  |.|.. |..| |..| ..  .||. .|. .|..|..||.... | ..|. .|.
kapllellrqvkv.anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Ptp69D_pd Subfamily Ptp69D 401-674 5.7e-43 142.2 In-house 24-286 (307) alignment 
Range on Protein: 401-674
Range on HMM: 24-286/307.0
YQAEYDQICKQtprFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVV
.. ||... ..   ..  ..  ... .|  |||    .. |. |  |.  .|.. .||||. |. || . ...|.   |.  |.|.|| .. .||   .|
lakeyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

VLCQPPSQSQ-QYPSFWPNKsKMEKYGPVfSVHYVMSKSYTNIKQWEFKINKKIVSLTEMmagvkAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMV-
.| .   ... . . .||.  .  .|| .  |..| ... ..  . |... ||  . .|.       .| |  .. | |.   ||| ....|. |...| 
mlsnlteknrkkcakYWpie.devqygdi.lvklvseekhsdyiiReldvskkkeesgev.....edsrkvvqyhytgWk.DskvPevargllklieqvr

EIWRNKvdYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
|. ...   .|. |    | .|.|.. | .  ..|. .  .||.|. || .|..|. ||...  |...|  .| | 
elykln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 110-369 1.5e-42 140.5 In-house 18-258 (267) alignment 
Range on Protein: 110-369
Range on HMM: 18-258/267.0
AKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKvgglQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDfakVM
   .|.|.   . ..| |.|.  . .||| .||.| .    .. .|.|||||..  . ||.||||.|.. |.  .. .. ..... ||.|||.|      
isdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvft...dn

CHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQevtDErlILQFHYTEWYSHS--CPFSNALLEfrrrvrLVVGNIIkdeDDMRGPIL
 ...|||.|   ..| |. ..   |..  ...| |. |   ||      .  .  ..| .|   .   |. . |.       ..  | .   ..   |..
irlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa...hn..vtlyyykkwnintnnkpylkplfg......ilaknql...engnrPlv

VHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEH
|.|||| |||| .. ||. || | .|.  ..| .|.|.|. | |||.  |.| .|...| |.
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 112-366 1.7e-42 140.2 In-house 25-273 (287) alignment 
Range on Protein: 112-366
Range on HMM: 25-273/287.0
VESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLqDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCH
  . | . | .  . .||.  . .|.| .||.| . | |  |||.|| || |  . .|.|..|||.  ||. .||.|.... ......|.  . |.  |.
sstatfkaaeelaavkknryadvlPiddtrvllsaegel.GsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPPNmEVHEQYGDIFINIVREEQL-ANFHIRTFRLYKMNEKqevtDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVgNIIKDeDDMRGPILVH
.||| . ||  . |   . ..  ...  .. .|..|| ... .    . |.. |... .| ... . .  .|. |   |.  . .. .|  .  ||..||
kywPer.evPmrvGGysvvlldydikePeygvralrlidletr....earvvkqldllswPdkvlaPtavglirfvldvkqhi.elard.asevGPlvvh

CSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL
.. | ||||..... . ..  |.    .|   . .||. |..||  | |....|..|
ddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
0045098 (Phosphotyrosine protein) phosphatases II 411-678 6.4e-42 139.2 In-house 16-276 (278) alignment 
Range on Protein: 411-678
Range on HMM: 16-276/278.0
QTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYltsfqgnaftDYINSVFVDGYtkPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQ-S
. . . ....  . . .|..||| .  .| |. | .          ||||  ..|||  |...|.| .|...|.  || ..... ....| |..      
llllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

QQYPSFWPNkSKMEKYGPvFSVHYVMSKSYTNIKQWEFKINKKIVSLTEMMagvkapTRTVQLFQLTCWPmGHKVPSST--NSLVYLMNMVEIWRN----
. .. .||. .... ||. |.|...  . . ..  . ...    |  .. .      .|.|. .....||  | |||..  .|.  |..... ...    
ekcaqywpe.ggsltygd.ftvtllseevlddytlrtllvtnltveredle......srgvthlhylpwp.dhgvpslpilksflellefirealkllas

--------KVDYGPVCVVSPDGRSRAGVYCAANACIEQViqHGEVDVFQAVKTVRRHRPQ-LVENMTEYKYCYDLVLHYVLHFL
          . ||| |    | .|.|...||  ..|..  .| ||...|||..|..||.  |.|.  |...|...|...|...
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 399-672 2e-41 137.0 In-house 24-277 (315) alignment 
Range on Protein: 399-672
Range on HMM: 24-277/315.0
NEYQAEYDQIckqtPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSA
| .. .|. |    |   .      ..  |..||| .  .. |. |..|   . .  .||.|. |.|||.|.| || .. |   ....|| ||...... 
ngfkqdyesi....pggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigk

VVVLCQPPSQSQQYPS-FWPNKsKMeKYGPvFSVHYVMSKSYTNIKQWEFkinkkivsltemMAGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNM
.|.| .  .. ..    .||.| |.  ||. ..|  .  . .|..    .               ..   |.|  ...|.||   .|| .| .|. |.  
ivmltnlvegekrkaekywpdk.kv.iyGk.itvtrkseevnteytvrtl............svvfgdnirevvqlhytswp.dmgvpkytiplmnlirt

VEIWRNKVDyGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLH
|  ....   |.. |   .|  |.| ... .| ..|.     .||..... ||. | ..|. . .|.. || .| 
vkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
0041856 (Phosphotyrosine protein) phosphatases II 125-377 6.2e-41 135.3 In-house 1-178 (182) alignment 
Range on Protein: 125-377
Range on HMM: 1-178/182.0
NLEKNQNPKCIPYDYNRvvlekvgglqDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTktfdfakvmCHQYWPPNMevheqy
||.||  .. .|||..|          |.||.||..... |... .|.||||  .|| ...||.....|..||.||         ...||| .       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

gdifinivreeqlanfhirtfrlykmnekqevtdERLILQFHYTEWYSHSCPFSNALLEFRRRVRLvvgniikdeddMRGPILVHCSDGGGRSGVYMSID
                                  |||..|..|. |  |..|  . ||.| ..|.              ||.||||| | ||.|..  ..
..................................erlgiqylylpwpDhgvpdldelldfieevle...........eggpvlVHCsaGvgRtgtlvaay

ANLELaeeeeCFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGKTWF
  ..|      ....  .| .|. | | |.. .|| |... | |.. ..||. 
lmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 426-677 6.4e-41 135.2 In-house 45-281 (287) alignment 
Range on Protein: 426-677
Range on HMM: 45-281/287.0
ADNREKNRDVLCVPPDNFRPYLTsfqgNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQ-YPSFWPNKSKmEK
 .|..|||    ..|||.|  |     .   ||||.||.||| . ...|..| || .|. .|| |. |.. .|.|.|||   . ..    .||...    
sqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vv

YGPvFSVHYVMSKSYTNIKQWEFKINKKivsltemmaGVKAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNMVEIWRnKVDYGPVCVVSPDGRSRAGVY
.|. .... .  . ...  . ......|         . ......|. .|.| |.   ||..   .|. . .|.   | |   ... |   |.  |....
lGe.yniellneevnagyierklevknk.........nkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqr.krgntsivvhCsdtvGrsamf

CAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHF
|||.  |... . | .|||| .|  |  .|. |  ...||. .|.||.|.  |
caaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
subfamily_PTPRB_pd Subfamily PTPRB 393-674 1e-40 134.7 In-house 19-285 (293) alignment 
Range on Protein: 393-674
Range on HMM: 19-285/293.0
NSGTKMNEYQAEYDQICKQTPRFTigdCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVY
..     ... ||... .     .   ..  ..| ||.|||    .| |. |  |.. .... .||||. ...||. |||.|.|  |. .|. .|| .|.
mkadsdlrfseeyeelkavgkdqa...vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvw

DQECSAVVVLCQPPSQSQ-QYPSFWPNKSKMEKYGPVfSVHYVMSKSYTNIKQWEFKINKkivsltemmagvKAPTRTVQLFQLTCWPmGHKVPSSTNSL
....|..|.| |   . . .   .||....   || . .|. |.......    |.||.|            .  .|.|. .. | ||  | ||..|..|
ekkssiivmltqlvekgkvkCeeYWPadeepvlyGdi.kvtlvaeeeledwvirelkiek............ekeerkvrqyhftsWp.dhgvPektktl

VYLMNMVEIWR-NKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
. ....|. .  .. . .|. |    |  |.|.. | .  .... ..  ||.|  |  .|..| .|| . ..| . .. ||...
ldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_PTPRA_pd Subfamily PTPRA 387-675 1.5e-40 134.1 In-house 20-296 (330) alignment 
Range on Protein: 387-675
Range on HMM: 20-296/330.0
KAKARRNSGTKMNEYQAEYDQICKQTprfTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGE
. . |. |    . .. |.. .   .     . .    . .|.|||| |  .| |  | .|.  .|.  .||||. |.||| .  ..| .  | ..|. .
eeeirirsaddnklfreefnalPagp...iqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetved

FWSLVYDQECSAVVVLCQPPSQSQ-QYPSFWPNKSKMeKYGPVfsvhYVMSKSYTNIKqwEFKINKKIVSlTEMMAGVKAPTRTVQLFQLTCWPmGHKVP
|| ....|. ...|.| .   . . .   .||..  .  || .     |  .  | ..  .. . | .|      |  . ..| |. | .| ||    ||
fwrmiweqksativmltelkerkeekcaqywPdeGlv.tyGni....rvevedetvlv..dytvrkflvq.qlpdatrekksrlvrqfhftswP.dvGvP

SSTNSLVYLMNMVEIWrNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVL
. .  .. |.. |.   |..  ||. |    |  |.| ... .| .|.|   . ||||..|| .|  |||.|     |...|  .|.| |
fepiGmlkllkkvkkl.nqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
0037934 (Phosphotyrosine protein) phosphatases II 421-673 1.5e-40 134.6 In-house 3-241 (243) alignment 
Range on Protein: 421-673
Range on HMM: 3-241/243.0
AGGHRADNREKNRDVLCVPPDNFRPYLtsfQGnafTDYINSVFVDGYtkPReYIVTEWPMKHTLGE----FWSLVYDQECSAVVVLCQPP-SQSQQYPSF
. ...  |..|||   ..| |. | .|   .|   .||||  .....  || .|.| .|...|. .    || ..... ....| |...   . .... .
siallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPnkSKMeKYGPvFSVHYVMSKSYTNIKQWEFKINkkivsltemMAGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRNK-------VDYG
||  ...  ||. |.|... .... .........          . . . .||.|. .. ..|| .|.||.|...|. ....|  . ..        . |
wp..gev.tygd.ftvtllseehlddytvrtllle.........nldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsgg

PVCVVSPDGRSRAGVYCAANACIEQViqhgEVDVFQAVKTVRRHRPQ-LVENMTEYKYCYDLVLHY
||.|    |..|.|...||  .....    .||...|||..|..||.  |..   |...|...|..
pvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
0051429 (Phosphotyrosine protein) phosphatases II 151-369 3.6e-40 133.7 In-house 2-224 (272) alignment 
Range on Protein: 151-369
Range on HMM: 2-224/272.0
QDSDYVNASYVDSLLK---PNAYIVTQGPVEETVQAYWRMvWQENISAIVMLTKTFDFAKVMCHQYWP----------PNMEVHEQYGDIFINIVREEQL
. |.|.||..|. . .   |.... ..|| . |.. .||. ....|..||.|....  ... |..|||          ....    ||.... .. ||.|
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

ANFHIRTFRLYKMNEKQEVtdeRLILQFHYTEWYSHSCPFSNaLLEFRRRVRLvvgniikdeddmRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFN
 ....|...|...   .|.   | ....||| |  |. | .  |||. . ..              ||.||||| | .|.|..  ..  |.  ..|  ..
ldyilrellltlllsagea...revmhlhytdwpdhgvpqea.llellellld............ggpvlvHCsaGkdRTGtvvallllllgvsletivd

--------VFGYLKKLRQSRKGLVENVEQYKFIYDTLEEH
        .......||. | | |.. |||.|.|. | | 
dYlltnlyleeaveelraqrpgavqteeqylflyeallel
0036282 (Phosphotyrosine protein) phosphatases II 153-364 1.3e-38 127.8 In-house 2-164 (174) alignment 
Range on Protein: 153-364
Range on HMM: 2-164/174.0
SDYVNASYVDSLLKPNAYIVTQGPVEetvqaYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPnmevheqygdifinivreeqlanfhirtfrlykmne
||| |||..|    .. .|..||| .     .|.|.....|...|||.. .   ...|..|||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

kQEVTDERLILQFHYTEWYSHSCPFSNALLEFRRRVRLVVGNiikdedDMRGPILVHCSDGGGRSGVYMSIDANLELAEeEECFNVFGYLKKLRQSRKGL
      |||..|..|. |  |..| .. |||| ..|. .. .      |  ||.||||| | ||.|. . ..  | . . |   ... ....||. | | 
.lredlerlgiqylylpwpDhgvpdlsillefvkfveealse......dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgm

VENVEQYKFIYD
|.. .||.|.|.
vqtpsQyrflyy
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 390-672 1.4e-38 128.0 In-house 25-289 (319) alignment 
Range on Protein: 390-672
Range on HMM: 25-289/319.0
ARRNSGTKMNEYQAEYDQICKQTPRFTigDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWS
 ...   .......|. ..||...  .  | .     .|..||| .  .. |. .  |   .|  |.||||. ||.|| ..  || .  |.. || .|| 
nksdfdddltklevefrracklgvnla..dqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWr

LVYDQECSAVVVLCqppsqSQQYPSFWPNKSKMeKYG-PVFSVHYVMSKSYtnikqweFKINKKIVSLTemmaGVKAPTRTVQLFQLTCWPmGHKVPSST
......||..|.|       ..   .||.| .. |..    .|. |   .        . . .  .|      | .   | .. | .  ||  . || ..
miweyncstivllt.....kdkcsqywplkivi.keerfkvkvdsveetae.......yvvrdielsed....gkekdirkitqfhflGwp.dvGvpdyp

NSLVYLMNMVEIWRNKVDY-GPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLH
  |. |.. |.  ..| .   .. |    |  |.||| . .. .... .   |||.. |. .|. |..||.....||..|  .| 
sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 403-672 3.6e-37 123.4 In-house 2-253 (284) alignment 
Range on Protein: 403-672
Range on HMM: 2-253/284.0
AEYDQICKQTPRFTigDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVL
.|. ..||...  |  | .     .|..||| .  .. |. .  |   .|. |.||||. |. || ..  || |  |.. || .|| ......||..|.|
vefrracklgvngt..dqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivll

CqppsqSQQYPSFWPNKSKMEKYGPVFSVHYVMSKSYtnikqweFKINKKIVSLTemmaGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWR
       ..   .||.| ....     .|. |   .        . . .  .|      | .   |... | .  ||  . || ..  |. |.. |.  .
t.....kdkcsqywplkivikeerfkvkvdsveesee.......yvvrdielsed....gkekdirkirqfhflgwp.dvgvpdypsdlmrlvkkvrhlt

NKVDY-GPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLH
.| .   .. |    |  |.||| . .. .... .   |||.. |. .|. |..||.....||..|  .| 
skenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 396-674 5.7e-37 122.0 In-house 12-293 (301) alignment 
Range on Protein: 396-674
Range on HMM: 12-293/301.0
TKMNEYQAEYDQICKQTPRFTIGDCAGGHRADNREKNRDVLcvPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQE
.. |.....|... ..... ..  .   ..| || ||  |.  . ...    ..    . ..|||. ..|||.. ...|... |||.|| .|| |.... 
khsnkfeeqykelkegedksctvglseenkalnrfknitvy..ddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

CSAVVVLCQPPSQ-SQQYPSFWPNKSKMEKYGPVFSVHYVMSKSYTN--IKQWEFKINKKIV-SLTEMMAGVKA--PTRTVQLFQLTCWPMGHKVPSSTN
 ...|....   .  ..   .||| .. ...   |.|  | .. | .  |.|   ||..    . .| .  ||.   ...|  .|.| ||    |.    
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

SLVYLMNMVeIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
 |  . ... . ..|.. ||| |   |. ||.||||. .  .||.   | ||||| .|.||| .|  |  .  |   || .  |.
vLqviddvi.hrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 425-674 1.4e-35 118.0 In-house 45-288 (325) alignment 
Range on Protein: 425-674
Range on HMM: 45-288/325.0
RADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQYPSFWPNK-SKME
. .|..|||    |. |. |. | . . .. .||||. ..  . |   .. .  |. .|....| ||.| .|| |||| .   . ..   .||.. .|  
kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksk

KYGPVfSVHYVmskSYTNIkqwefkiNKKIVSLTEMMAGVKAPTRTVQLFQLTCWP-MGH-KVPSSTNSLVYLMNMVE--IWRNKVDYGPVCVVSPDGRS
..|..  |. .   .  .|          .    ..    |  ||.|. |||  |. ||  | |..  |.. |.. |.  .  |    .|. |   .|  
tfGgl.evklr...tieei.......sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvG

RAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
|.||. .  . ...||.. .||.|. || .|..||..|| . .|  .|. .  ..
rtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
0049772 (Phosphotyrosine protein) phosphatases II 100-369 7.1e-35 116.6 In-house 21-279 (314) alignment 
Range on Protein: 100-369
Range on HMM: 21-279/314.0
VLYKLEFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDyNRVVLeKVGGLQDSDYVNASYVDSLlkpNAYIVTQGPVEETVQAY----------WRMV-
.|..| . .     ..|.  | .  | .|| .....|.| |||.| .  . ..||| ||||||.    ...|.|||| |.||  .          |||| 
lllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvl

-WQENISAIVM---------------------LTKTFDFAkvmchqywppnmevheqygdifiNIVREEQLANFHirtfrlykmnE-------KqevtdE
 .. |.  |||                     |..   .                        |.  .. |....          |             |
rgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.......................neptaadlellk..........eelydpelf.....e

RLILQFHYTEWYSHSCPFSNALLEFRRRVRLVvgniikdedDMRGPILVHCSDGGGRSGVYMSIDANLELAeeeeCFNVFGYLKKLRQSRK-----GLVE
||....... .. .|.| .. ..|| . .. .         |  ||.||||..| ||.|... ..  . |      ...   |. .|. |      |..|
rlgikylripvpDgsaplledfdeflefieea.........dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfie

NVEQYKFIYDTLEEH
. ||| ||.. |.|.
qleqyefilealley
subfamily_PTPN6_pd Subfamily PTPN6 381-675 1.1e-34 114.8 In-house 8-298 (306) alignment 
Range on Protein: 381-675
Range on HMM: 8-298/306.0
ELSDRLKAKARRNSGTKMNEYQAEYDQICKQTPRFTIgDCAGGHRADNREKNRDVLCVPPDNFRPYLTsFQGNAFTDYINSVFVDGY--TKPREYIVTEW
|...| .   . .. .. . .. |.... ..  . .. .   |....|.||||    .| |. |  |.  .. . .||||. ....   .. ..|| |. 
eieqrvselekeeeslekagfeeefeelqqeeakkll.srkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqg

PMKHTLGEFWSLVYDQECSAVVVLCQPPSQ-SQQYPSFWPNKSKMEKYGPVfSVHYVMSKSYTNIKQWEFKINKKivsltemmaGVKAPTRTVQLFQLTC
 ...|. .||..|.....  .|.. .   .  ..   .||.... |.|| . ||. | .|| .. .  |....||           |  .|.|  .. . 
clettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGki.svtnvseksladYilRelsvskk.........kkkkeerevfqyhfks

WPMgHKVPSSTNSLVYLMNMVEIWRNKVD---YGPVCVVSPDGRSRAGVYCAANACIEQVIQHG---EVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVL
||  | ||.... .. ... |.  ....     ||..|   .|  | | .   .. .... ..|   ..|. ..||.||..| .||   . ||. |  . 
WPd.hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik

HYVL
.|. 
kyie
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 425-675 1.3e-34 114.7 In-house 45-285 (297) alignment 
Range on Protein: 425-675
Range on HMM: 45-285/297.0
RADNR---EKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKprEYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQYPSFWPNKSK
 |...   ||.|    .| |  |  | . . .   ||.|. || |. .  ..| |. ||| |. .|| .|.|.. |..|.| .   . ..   .|..|. 
vaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgv

MEkYGPVFSVHYVmsksytnIKQWEFKINKKIvSLTEmmaGVKAPTRTVQLFQLTCWPMGHKVP-SSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSR
.. .| |  |          ... |  |.... ..|.   |    .| |. .| . ||        |..||. |.. |.   ...  ||. |    |  |
tt.fGdvsvvlls.......vsereGfikrel.evtk...gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGr

AGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVL
.||... . .. .. .. |||.|. || .|..||.||    .||. | .|| ..|
tgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
0046846 (Phosphotyrosine protein) phosphatases II 150-367 3.5e-34 113.4 In-house 9-170 (176) alignment 
Range on Protein: 150-367
Range on HMM: 9-170/176.0
LQDSDYVNASYVDSllkpNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEqygdifinivreeqlanfhirtfrlyk
  |.||.||.....    ...|.||||...|......|.....|.|.|.||. ...... |..|||  ....                            
dldldyinanlilg....srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

mnekqevtderlilQFHYTEWYSHSCPFSNALLEFRRRVRLVVGNiikdeDdmrGPILVHCSDGGGRSGVYMSIDanleLAEEEECFNVFGYLKKLRQSR
              |.... |  |..| ...|||. . .| .. .     .   ||.||||| | ||.|..  ..    | | | ...|.  |...|. |
..............qylhlpwpDhgvpdlelllellefirealke.....g...gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqR

K-GLVENVEQYKFIYDTLE
  | |.. |||.|.|. . 
plgavqtpeQyrflyefel
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 386-675 4.1e-34 113.0 In-house 2-277 (281) alignment 
Range on Protein: 386-675
Range on HMM: 2-277/281.0
LKAKARRNSGTKMNEYQAEYDQICKQTPRFTigdCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLG
|.......|  . . .. ||... .   . |       .. .|..||| .  |  |. |  .|  . |  |||||. ||.||....|||.|. |. ..| 
lrkhlkqlsqndnaGfieeyeklaaigvdnt...ataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslv

EFWSLVYDQECSAVVVLCQPPSQSQ-QYPSFWPNKSKMEKYGPVFsvhyvmsksytnIKQWEFKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWPmGHKV
.|| .|..|. ||.|.. .   ... .   .||....  ||| |             .|. . . ... .. . ..   ...||.|. .. | ||  | |
afWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvt............vkstaeeekatyierkfkleresgetreveqlaytaWP.dhGv

PSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVI-QHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVL
|..|. |.   . |.  ..|    |...    |  |.|.| | .  ...|  .. |.|| . |. .|..|  .|  .. |.. |  ||... 
PattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0043147 (Phosphotyrosine protein) phosphatases II 152-363 4.5e-34 113.0 In-house 4-154 (172) alignment 
Range on Protein: 152-363
Range on HMM: 4-154/172.0
DSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTfdfakvmchqywppnmevheqygdifinivreeqlanfhirtfrlykmn
.|||.||||.|   .|. .|.||||  .|.  .|||.....|..||.||.                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

EKQEVTDERLILQFHYTEWYSHSCPFSNALLEFRRRVRLVV--GNiikdeddmRGPILVHCSDGGGRSGVYMSIDANLelaeeeECFNVFGYLKKLRQSR
..     |||..|..|. |. |..| .. |||| . .. ..   .         ||.||||| | ||.|.   ..  |      ......  .. .|. |
lydpellerlgiqylylpwpDhgvpllellleflefidellalsp........ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekR

KGLVENVEQYKFIY
 | |.| .||.|.|
pgavqnpsqyrfly
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 401-675 6.2e-34 112.3 In-house 17-278 (315) alignment 
Range on Protein: 401-675
Range on HMM: 17-278/315.0
YQAEYDQICKQTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVV
. | . .  .. |   |     .   .| .|||    .| |. |  |   . .   ||||. .. .. . . || .  | | .. .||..|.... ...|
htalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttiv

VLCQPPSQSQ-QYPSFWPN-KSKMEKYGPvFSVHYVMSKSYTNIkqwefkINKKIVslteMMAGvkAPTRTVQLFQLTCWPMgHKVPSSTNSLVYLMNMV
.. .   . . .   .||. |..  ..|  ..|. .  .. |.       ...|.|    .  .    .|||  ||.| ||  . |.  | ||. |.  |
mvtkkqegdkikcrqywPdrkadsvefGs.ikvellsleadtdg......varklv....trks..eesrtvtqfqftewPd.kGvdkqtssllklikev

EIWRNKVDYgPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVL
   ..| .. .. |    |  |.|| .... ...|. .   ||||. ||..|..||.||    || . || || ..|
kadngkkef.sllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN9_pd Subfamily PTPN9 402-675 7.1e-33 108.9 In-house 19-291 (297) alignment 
Range on Protein: 402-675
Range on HMM: 19-291/297.0
QAEYDQICKQTPRFTIgdcAGGHRADNREKNR--DVLCVppDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAV
. || .| ....  |.      .   | ||||  ||||.  |. |  |.. ...  .||||. ||||| ... .| |  |.|.|  .|| .|..||.  .
skeyaeirnepveGtf...lasklranleknrytdvlcy..detrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

VVLCQPPSQSQ-QYPSFWP-NKSKMEKYGPvFSVHYVMSKSYTNIKQWEFKINKKivsltemMagvKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMN-
|.  .   . . .   .|| .. .....|  .||. |  ... . |.  ..|..            .  .|.|  ||.. ||  . ||||..||. ... 
vmttrvvergrlkcgqyWpleeessaefgd.lsvsnveveeeedykvrvleiknv.......k...teesrkvthfqflsWP.dyGvPssaaslldvlek

-----------MVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVL
           . . |. ...  |. |    |  |.| ... . |.... . | |||...||..|  |   .     |..||  || | |
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 105-368 1.3e-32 108.0 In-house 21-275 (307) alignment 
Range on Protein: 105-368
Range on HMM: 21-275/307.0
EFQTAAKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGgLqDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFD
||.  || . ..      . | .||.       | .|.|..  | |  |||. | |.   .||. .|..||| |.|.. .| |. ||.. ...|| |. .
efrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdg.l.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvie

FAKVMCHQYWPPNMEVHEQYGDIF----INIVREEQLANFHiRTFRLYKMnEKQEVTDERLILQFHYTEWYSHSCPFSNallefrrrvrLVVGNIIKDED
 ||. |.|||| .   .  .|.      .. .  ..||  .     . .. . .   . | | .. ...|  . .|  |          |   |...   
lakikceqywpleegqklvfgeapntisvanlgakklapde.dlinvttl.kvdwaqksrtiqhlqwenwpdrgvpqin..........ltainlleavr

DMRGPILVHCSDGGGRSGVYMSIDANL-ELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEE
  . |..|||| | ||||  ..|      . . ..| ..   ...||. |.  ...  || ...  | |
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlle
subfamily_PTPN12_pd Subfamily PTPN12 397-679 1.8e-32 107.4 In-house 6-282 (290) alignment 
Range on Protein: 397-679
Range on HMM: 6-282/290.0
KMNEYQAEYDQICKQTPRFTIGD---CAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYD
  .|...|. .. |.. ..   .    . |..  |..|||    .| |. |  |.  ...   ||||. |. | ... ||| .  |. .|| .|| ....
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwe

QECSAVVVLCQPPSQS-QQYPSFWPNKSKMEK-YGPvFSVHYVMSKSYTNikqwEFKInkkivslTEMMAGVKAPTRTVQLFQLTCWPmGHKVPSSTNSL
.. . ||..|.      ..   .||.. ..|  .|. |.|     |  ..    .| |         . . ..  .|.|. |. | ||  | ||||..||
knveivvmaCrevelgkkkCerYWpeegeeelefge.fevtleeekavdd....dfli.......rtLkveaqkesrkvyqfhYtaWP.DhgvPssaksl

VYLMNMVEIWRNkVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQH---GEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFLN
. |...|.  ..  .  |..|    |  |.|. .| .   |.. ..    |.|||. | ..|..|. ||     |.. |  |...| . |.
lelielvrelqe.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 118-364 2.7e-32 106.6 In-house 48-277 (290) alignment 
Range on Protein: 118-364
Range on HMM: 48-277/290.0
RHALKKNN-LEKNQNPKCIPYDYNRVVLEKvGGlqDSDYVNASYVDSLlKPnAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPP
|. . ||  ..||.    .  |  ||.|.  |.  | ||| | ||. | |.  .|.|||....||  .|||| ||...||||| . ..  |  |.||.| 
rkifdkntefkknrykdvvcndktrvilkd.Gy..dGdyvhanyvkGl.ka.mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype

NMEVHEQYGDIFINIVREEQLANfHIRTFRLYKMNEKQevTDERLILQFHYTEWYSHSCPFSNA-LLEFRRRVRlvvgniikdedDMRGPILVHCSDGGG
.      .|.| .    |..  . .|    |  .. ..    |  .  ..   |  .| . |.  ||   | .|            . ||. |||| | |
keGevltfGeitvlcseeddkda.niikktlsvrdkds..Gkehklkhlkikswpdksvalstlallrtlrilr...........kasGpvvvhcsaGiG

RSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYD
|.| ...|.. |..  .   ... .  . ||.|| . |.   ||  . .
rtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalve
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 428-675 3.9e-32 106.0 In-house 43-277 (515) alignment 
Range on Protein: 428-675
Range on HMM: 43-277/515.0
NREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQ-YPSFWPNK-SKMEKY
| .|||    .| |. |  |   . |   ||.|. .. ..   . || .  | | .. .||.||.... ...... .   . .     .||.| ..  |.
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GpVFSVHYVMSKSYTNIkqwefkINKKIvsltEMMAGVKapTRTVQLFQLTCWPMgHKVPSSTNSLVYLMNMVEIWRNKVDyGPVCVVSPDGRSRAGVYC
|  ..|. |  .. |.       | .|.    ... | .  .|||  |..| ||  . ||  |.||. |.  |   ....   |. .    |  |.||..
G.sikvelvsleactgg......ikrkl....tvlkgdd..srtvtqfhfteWPd.kGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvi

AANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVL
... .. .. .   ||||. |. .|..||.||    .| . |. || ..|
sidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
0049260 (Phosphotyrosine protein) phosphatases II 161-364 1.5e-31 104.6 In-house 2-144 (152) alignment 
Range on Protein: 161-364
Range on HMM: 2-144/152.0
VDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWppnmevheqygdifinivreeqlanfhirtfrlykmnekqevtder
.|   .|...| |||| ..|.  .|||... .|..|||||. ....|. |.||.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

lilQFHYTEWYSHSCPFSNALLEFRRRVRLVVgniikdEDDMRGPILVHCSDGGGRSGVYMSIDANLelaeeeECFNVFGYLKKLRQSRKGLVENVEQYK
   |.... |  |..| .  ||.|  ..            |  ||.||||| | ||.|... ..  |        .... ... .|. |.| |.| .|..
...qylhlpwpDhgvpdlsqlllflllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlr

FIYD
|.|.
flye
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 428-674 4.2e-30 99.8 In-house 28-268 (274) alignment 
Range on Protein: 428-674
Range on HMM: 28-268/274.0
NREKNRDVLCVPPDNFRPYLTSFQGNAF-TDYINSVFVDGYTK-PREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQ-QYPSFWPNKSKM--
. .|||    .| .| |  |.| ....  ..|||. .. || .  . |. |  |. .|. .|| ..| .|.. .|.| .   . . .   ..|.. ..  
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

-EKYGPVFsvhyvmsksytnIKQWEfKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRNKVD--YGPVCVVSPDGRS
 |.|| |             ||  . .....  |.....      .|.|. .  | ||  ||.| ..|.|. |.. ||  |.. .   .|| |    |  
serygdve............ikvek.iverndysvrklvlkylerersvkhywytdWP.dhksPddantlldlvleveesreeenaklapvvvhCsaGiG

RAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
|.|.. |.. .. |. ... |||.. |  .| .|  .|..   |.. .  . .|.
rtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 120-366 5.6e-30 99.2 In-house 28-291 (297) alignment 
Range on Protein: 120-366
Range on HMM: 28-291/297.0
ALKKNNLEKNQNPKCIPYDYNRVVLEkvGGLQDSDYVNASYVDSL--LKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPN
| ... | ||.  . . .| .|| |   ..  ..||.|| ||      ..  ||..|||...||. .|..|..... .|||..|  .  .  |  |||  
akrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

MEVHEQYGDIFINIVRE--EQLANFHIRTFRLYKMNEKQEVTDerlilqFHYTEWYSHSCP--------F-------------SNALLE-FRRRVRLVVg
 .   . ||. .. . .  ..  . ..  ..|.  .|.. |.         .  |  |  |        |               ||.| |   | | . 
vqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrh......vqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflql.

NIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL
. .. |     ..||||| | ||||| .  |. |.    .   .|   |..||. |  ||. .||....||  
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydav
subfamily_PTPN23_pd Subfamily PTPN23 428-681 6.2e-30 99.0 In-house 43-287 (288) alignment 
Range on Protein: 428-681
Range on HMM: 43-287/288.0
NREKNRDVLCVPPDNFRPYLTsfqgNAFTDYINSVFVDGYTK-PREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQ-YPSFWPNKS-KMEK
. ||||   ..| |. |  |     .   ||||  || . .    ..|.|  |.. ||..||..||.|  | .|.| ... . ..   ..||..  . .|
yseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

YGPvfsvhyvMSKSYTNIKQWEFKINKKIvSLTEMMagvKAPTRTVQLFQLTCWPMgHKVPSSTNSLVYLMNMVEI----WRNKVDYgPVCVVSPDGRSR
.|.       .| .  . .. |  ..... .|.      .  ...|.. ||| ||  . ||.| ..|. ... ||      ..|..  |. |    |  |
fgd.......lsvtlksvretethvervl.kletld...adavksvshlqltsWpe.lGvPasPetllqfldevesayeavqrkskt.PlvvhCsaGvgR

AGVYCAANACIEQV-IQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFLNKK
.||..   | ....  ..| .|. | |...|. |   |.. ...| .|. ||... . |.|.
tgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkr
subfamily_ptpA1_pd Subfamily ptpA1 117-321 1.6e-28 94.6 In-house 39-247 (418) alignment 
Range on Protein: 117-321
Range on HMM: 39-247/418.0
CRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLlKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPP
     || |  ||.  . .| .. || |.|.   . |||.|| |.|    |. .|.||||. .|.  .|||||..    ||||..  . ... | .||| 
tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpe

NMEvHEQYGdIFINivREEQLANFHIRTFRLYKMNEKQEVT---------DERLILQFHYTEWYSHSCPFSNalLEFRRRVRLVV--GNIIKDEDDMRGP
..   ||.  |. |   .| .  . .    . .  |.. .|         . | | |..|  |  |  |       ||. .. .    | |    |   |
qig.geqfs.iygn..gnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdht..qpfrqllhsitnrqnqiipssdrnvp

ILVHCSDGGGRSGVYM
|.|||| | ||.| . 
iivhcsagvgrtgtfc
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 425-674 4.4e-28 93.0 In-house 30-266 (283) alignment 
Range on Protein: 425-674
Range on HMM: 30-266/283.0
RADNREKNRDVLCVPPDNFRPYLTSFQGnaftDYINSVFVD---GYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQ-QYPSFWPNKS
  .|..|||    || |..|  | |       ||||.||.     | . ..||..  |...|  .|| .|.|.. .|.|.| .   . . .   .||.. 
adenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG

KmEKYGPvF--SVHYVMSKSYTNIKQWEFKINkkivsltemmaGVKAPTRTVQLFQLTCWpMGHKVPSSTNSLVYlMNMVEIWRNKVDYGPVCVVSPDGR
  |.||. |  ...  ...    ||.   . |           .    |  .  .|.  | .     .  ||||  .| |   ...   ||. |    | 
s.edyGe.ftvtlrkettsnsfiikelllrvn...........ssakstlllahyqvidW.leygeqaiinslvk.fnkvislqteskkgPivvhCstgi

SRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
 |..|..|| | ....  .  ||||. || .| .|. .| ..  ||  ..|||   
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 113-366 5.1e-28 92.5 In-house 25-265 (281) alignment 
Range on Protein: 113-366
Range on HMM: 25-265/281.0
ESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEK-VGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCH
 |. |    .  | .||.  .    |  || |.  .   . .||. | |. | .    ||.|||| .||   .|||.|||| .||||| .  .  .  | 
psdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekca

QYWPPNMEVHEQYGDIFINivREEQLANFHIRTFRLYKMNEkqevTDERLILQFHYTEWYSHSCPFSN-ALLEFRRRVRlvvgniikdedDMRGPILVHC
.|.| |  .  |.  . ..   |.   |  . | ||    |     . ||| .. . ||     | |   .|.  |..|               | ..||
eyfprnahcclqfdklsvs..yedstvnkslvttrlnlsye....getrlithwlwkewpdwqvpessevmlkilrkir...........arstppvihc

SDGGGRSGVYMSIDANLELAEEEEC-FNVFGYLKKLRQ-SRKGLVENVEQYKFIYDTL
| | ||||  |...  |.         ..   . .||   |   |. ..|| .|.  |
sagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
0044763 (Phosphotyrosine protein) phosphatases II 136-369 5.9e-28 93.1 In-house 1-170 (178) alignment 
Range on Protein: 136-369
Range on HMM: 1-170/178.0
PYDYNRVVLEKVGGLQDSDYVNASYVDsllkPNAYIVTQGPveetvQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEvheqygdifinivree
|.| .||.|... ||. ||| |||...    |. |. ...|     ...........|..||.||...   .. |..||| ...                
pldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

qlanfhirtfrlykmnekqevtderliLQFHYTEWYSHSCPF-SNALLEFRRRVRLVVgniikdeD--DmrGPILVHCSDGGGRSGVYMSIDANLELaee
                           .|.... .  |..|  .  .||| . .. ..       |  .  ||.||||| | ||||. . ..  ..|   
...........................iqylhipipDhgvpdllehflefvefieeal.......dekg..gpvlVHCsaGvgRsgtlvaaylmkkl...

eeCFNVFGYLKKLRQSRKgLVENVEQYKFIYDTLEEH
   ....  .. .|. |   |.| .|....|.  ...
..glsleeaielvrerRp.ivpnpgqlrqLyefelrl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 399-673 1.1e-27 91.6 In-house 10-276 (287) alignment 
Range on Protein: 399-673
Range on HMM: 10-276/287.0
NEYQAEYDQICKQTPRFTIGDCAGgHRADNREKNRDVLCVPPDNFRpYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSA
.. ..|.|.... .   |.   |  .   . .|||    .| |. |  | | .|.  .||||. .| .||.  ..|..  |.  |...|| .|.... ..
ddvdkevdalkedsesstatfkaa.eelaavkknryadvlPiddtr.vllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsas

VVVLCQPPSQS-QQYPSFWPNKSKMEKYGpVFSVHYVmskSYTNiKQWEFKINkkIVSLTEMMaGvkAPTRTVQLFQLTCWPMGHKVPSSTNSLVYLMNM
|... .   .. ..   .||.. .  . |  .||  .   .|.. |. |. .    . | ..  .    .| |. ..|  || .   |..   . . ...
vitmtreveearlkcykywPerevPmrvG.Gysvvll...dydi.kePeygvr..alrlidle.t..rearvvkqldllswPdkvlaPtavglirfvldv

---VEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHY
   .|. |.  . ||. |    |  |.|.. |  .....  . |.||| ..|  .| .|  ||  .  ... |. .  |
kqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_PTPN3_pd Subfamily PTPN3 402-672 2.6e-27 90.4 In-house 18-273 (280) alignment 
Range on Protein: 402-672
Range on HMM: 18-273/280.0
QAEYDQICKQTPRFTIGDCaggHRADNREKNRDVLCVPPDNFRPYLTSfqGNAftDYINSVFVD----GYTKPREYIVTEWPMKHTLGEFWSLVYDQECS
 |...|. .. |  .|  .   ....| .|||    .| |. |  |..  ...  ||||. .|.    . .    ||.|  |...|  .|| .|..|..|
laqfeqlyrkkpglaisaa...rkpenlsknryrdilpydatrvklke..set..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss

AVVVLCQPPSQSQ-QYPSFWPNKSKMEKYGpVFSVHYVMSKSYTNIKQWEFKINKKivsltemMagvKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMN
 .|.| .   . . .   .||....  .||  |||.   ... ...   |. ...|           .   |..  .| . ||  |.||....... ...
livmlttlverGrvkChqyWPetedeleyg.efsvkcekedetksyvlrelvlkdk.......e...tkeerkilqlqylaWp.dhgvPddsadflefve

MVEIWRNkVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLH
 |.  |. ..  || |    |  |.||. . . ..  . .. .| . . |.|.|  |  ||.... ||.  . .|.
rvrklrs.gkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 398-673 2.8e-27 90.3 In-house 19-278 (439) alignment 
Range on Protein: 398-673
Range on HMM: 19-278/439.0
MNEYQAEYDQICKQTPRFTIGDCAGGHRADNrEKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECS
 . .. ....|    | ..   .   .  |.  |||    .. |  |  |    |   . |||. ...|| ... || |. | |.|  .|| ||... ..
qeifkeifekinstspdyaciaslaaqeydq.tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktv

AVVVLCQPPsQSQQypsFWPNKSKMeKYGPVfsvhyvMSKSYTNIKQWEFKINKKIVsLTEMMAGVKapTRTVQLFQLTCWPMgHKVPSSTNSLVYLMNM
 .|.|..   .| .   .|| ....  || .      . .   ||.  .. |    | . |   . |   |||  |. ..||  ..||. .  .. ..  
tivmltnlv.esyk...ywpsdaev.cygdi......avrvdrnielpnyvirgfkv.fnerdttek..ertvlqfhyiawpd.knvpaqashvldflra

VEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHY
..   .| .|||| |    |  |.|   | . ..||.    .||.   || .|..| |.|... .| . |. ||  
insandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_PTPN14_pd Subfamily PTPN14 403-674 5e-27 89.7 In-house 27-296 (300) alignment 
Range on Protein: 403-674
Range on HMM: 27-296/300.0
AEYDQICKQTPrftIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNaFTDYINSVFV--DGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVV
.||..| |.      ...  ..  .| ||||.   .| .. |  |.. . |  |.|||.  .     .| |.|||.  |...|. .|| .|..|. . .|
teyeripkkre...dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqliv

VLCQPPSQ-SQQYPSFWPNKSKMEKygpvfSVHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGvkaPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVE
 | .   .  ..  ...|.... .|     .|..   | .|. ..   ..  . . |  ....     |||  .| | ||  |.||.  .. .  ...|.
mlteeeedgkeksfkyfPkleskkk.....tvefgkfkvttkfsedsdsvittglklkhlpsk...eertvwhlqytDWp.dhgvPeDvkgflsyLeevq

IWRNKVDY--------GPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
  |.|..          || |   .|  |.||   ..  |. . .  |.|. ......|. |  ||.... ||. |.....|.
svrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
0041856 (Phosphotyrosine protein) phosphatases II 428-676 8.2e-27 89.4 In-house 1-173 (182) alignment 
Range on Protein: 428-676
Range on HMM: 1-173/182.0
NREKNRDVLCVPPDNFRpyltsfqgnaFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCqppsqsqqYPSFWPnkskmekygp
|..||| .  .|.|. |          . ||||  ...|. .....|.| .|...|. .|. ..... ....| |.         .  ||          
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp..........

vfsvhyvmsksytnikqwefkinkkivsltemmagvKAPTRTVQLFQLTCWPMGHKVPsstnsLVYLMNMVEIWRNkvDYGPVCVVSPDGRSRAGVYCAA
                                    .  .|..  .. . || ..  .     |  | ...|....  . ||| |    |..|.|...||
....................................ellerlgiqylylpwpDhgvpd.....ldelldfieevle..eggpvlVHCsaGvgRtgtlvaa

NACIEQviqhgEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLH
  ....     .|....|||.||..||. |...  | ......|...|.
ylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 426-674 1.2e-26 88.3 In-house 18-264 (270) alignment 
Range on Protein: 426-674
Range on HMM: 18-264/270.0
ADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYT-KPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQ-QYPSFWPNKSKME
| ... ||    .|  . |  | . . .  | |||  .| |.. ....|| .  |.. || .|| ...... .|.|.. .   . . .   .||...| .
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

KYGPVFSVHyVMSKSytnIKQWEFKINKKIvsltemMAGVKAPTRTVQLFQLTCWPmGHKVPSSTN------SLVYLMNMVEIWRNKVDYG-PVCVVSPD
       .. |.. |    .. |. | ...          |. .| .  |. . ||  | ||....      .|..... |  .... | . |. |   .
vkledgkik.vlals...eekeegyiltrl......rleekgeerrlvHfwyntWp.dhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
|  |.|.  | . ... . ....||| . .. .|..|..||. . .|.. |  |..|.
GvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 125-366 2.2e-26 87.2 In-house 55-285 (305) alignment 
Range on Protein: 125-366
Range on HMM: 55-285/305.0
NLEKNQNPKCIPYDYNRVVLEKVGglqDSDYVNASYVDSLLKPN-AYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNM-EVHE
.  ||.       | . | |.|      |||. | ||   . |.  .|..|||...|.. .| || |...  |||| || .  |. | ||||  . | .|
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

QYGDIFINIVREEQLANFHiRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPFSN-ALLEFRRRVRlvvgniikdedDMRGPILVHCSDGGGRSGVYM
  . | .. |   .  .      ..  .|      ..  . ....|||     |  . . ||.   .|             . ||.|||| | ||.|  .
lksgivvenvsgskpmerd.aeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair...........gskvpivvhcsagigrtgtiv

SIDANLE-LAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL
.|.  || .||. .|  .   .| ||. |   ..|  || ||.  .
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvm
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 400-678 2.6e-26 87.2 In-house 7-263 (267) alignment 
Range on Protein: 400-678
Range on HMM: 7-263/267.0
EYQAEYDQICKQTPRFtiGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNaftdYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAV
|.. |...| | ..      ..     .|.|.||    .| |. |  |   . .    |||. .|.|| . . .|||. |.| | ..|. .. ||... .
eiekefelikkisdts..stisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VVLCqpPSQSQQYPSFWPNK-SKMEKYGPVfSVHYVMSKSYTnikqwefkiNKKIVSLTEMMAgvKAPTRTVQLFQLTCWPMghkvpsSTNSLVYLMNMV
|.|   ..  .. . ||| |  . .||  . .| . . |            . .|..|   .   .  .. | |.    | .       ||   ||  ..
vllt..kvftdnirlfwPPkmgqakkyqdl.tvehslekeen.........dyqiitlelkfk..nesahnvtlyyykkwni......ntnnkpylkplf

EIW-RNKVDYG--PVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFL
 |  .|... |  |. |   ||  |.| .  ... .|.. . | .|.|. .. .|  |. ||. . .| |...|. .|    |
gilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrl
subfamily_PTPN1_pd Subfamily PTPN1 400-672 2.7e-25 83.6 In-house 7-269 (290) alignment 
Range on Protein: 400-672
Range on HMM: 7-269/290.0
EYQAEYDQICKQTPRFTigdCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGnaftDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAV
 |.. | .| |..  |.   ..  ..  ||..||     | |  |  | . .     ||||. .|.     |.||.|  |. .| . || .|..|.. ||
lykeiyldirkeasdfp...treaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskav

VVLCQPPSQ-SQQYPSFWPNKSK---MEKYGPVFSVHYVMSKSYTNIKQWEFKINKkivsltemmaGVKAPTRTVQLFQLTCWPmGHKVPSSTNS-LVYL
|.| .   . ...  ..||.. .   ..     ..|...  ... . .   .....               ||..  |  | ||    ||.| .. | .|
vmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen..........lktqetreilhfhyttwp.dfgvpespaaflkfl

MNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGE---VDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLH
... |    . |.||. .    |  |.| .| ...|. .. ....   ||. . .  .|..|  |.  .   .. |  .|.
fkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_egg_pd Subfamily egg 111-364 5.1e-25 82.8 In-house 26-264 (307) alignment 
Range on Protein: 111-364
Range on HMM: 26-264/307.0
KVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFakVMC
 |.  . ..|...||||| ....    |. || ||   |    |.. | .|.     | .|..| |. .||. .||||.||..  ||||| . .     |
svdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erc

HQYWPPNMEVHEQY--GDIFINIVREEQLAN--FHIRTFRLYKMNekqevtDERLILQFHYTEWYSHscpfSNALLEFrrrvrlvvgNIIKDEDDMRGPI
. |||   .   ..  | . |. .. .. |.  |..  ..|   .      || . |.    ..       |.    .         ....   ..  |.
eyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd......deerflehwqgdvnns....sdvyspl.........rvlrklrnlskpv

LVHCSDGGGRSGVYMSIDANLE--LAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYD
.|.. .|  .... ..|.  |   |      . |    . ||. |.  || | .| |.| 
vvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyr
subfamily_PTPRN_pd Subfamily PTPRN 400-678 7.7e-25 82.2 In-house 30-296 (297) alignment 
Range on Protein: 400-678
Range on HMM: 30-296/297.0
EYQAEYDQICKQTPRFTIgdCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFV-DGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSA
  ..|.. .|.     .   .. ... .| .|||   ..| |. |  |.. . .  .||||. .. |   .   || |. |. .|. .|| .|..| .  
rlekewealcayeaepst..kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

VVVLCQPPS-QSQQYPSFWPNKSKmEKYGpVFSVHYVMSKSYTNikqwEFKInkKIVSLTEMMagvKAPTRTVQLFQLTCWPMgHKVPSSTNSLVYLMNM
.| |..    . .|   .||.. . | |. .. || |  . ...    .. .  .   | ..    .  ||||  |    ||  . ||.|..||. .   
ivnltrleeegvkqckrywpdeGs.evyh.iyevhlvsehiwcd....dylv..rsfylknlq...tsetrtvtqfhflswpe.egvPasaksllefrrk

VE-IWRNkvDYGPVCVVSPDGRSRAGVYCAANACIEQVIQH-GEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFL
|.  .|      |. | . ||  |.|||.. .  ......   |.|.  ... .|  ||.||.   ......  | . | . |
vnksyrG..rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnail
PTPc_DSPc_SM00012 263-366 1.6e-24 81.5 In-house 3-103 (105) alignment 
Range on Protein: 263-366
Range on HMM: 3-103/105.0
LQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGNIIKdeddmRGPILVHCSDGGGRSGVYMSIDANLELAEEE-ECFNVFGYLKKLRQSRKGLVENVEQYK
 ..|||.|  |..|  |...||. | |. .  .. .     ..|..||||.| ||.|... .|  |.  |.| .....| ..|.||..| |.|.. ||| 
khyhytgwpdhgvPeesdsilellravkknknkses.....skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqyl

FIYDTL
|.|. |
flyral
0036282 (Phosphotyrosine protein) phosphatases II 456-668 1.7e-24 81.9 In-house 2-164 (174) alignment 
Range on Protein: 456-668
Range on HMM: 2-164/174.0
TDYINSVFVDGYTKPREYIVTEWPMKhtlgeFWSLVYDQECSAVVVLCQPPSQS-QQYPSFWPNkskmekygpvfsvhyvmsksytnikqwefkinkkiv
.||||  ..|..  ....|.. .|..     || ..... ...|| |...        . .||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

sltemmaGVKAPTRTVQLFQLTCWPMGHKVPSSTnsLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIqHGEVDVFQAVKTVRRHRP
         . ..|..  .. . || ..  ..|.  |  ... || .... . ||| |    |..|.|. .||  .. . . .. ||... |...|..||
.......lredlerlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrp

QLVENMTEYKYCYD
. |...  |...|.
gmvqtpsQyrflyy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 169-364 9.8e-24 78.6 In-house 5-197 (198) alignment 
Range on Protein: 169-364
Range on HMM: 5-197/198.0
AYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLykMNEKQEVTDERLILQFHYT
 ||.|| |. ||.  .|.|||.     |||.       ..    |||       .|| . .        ... | .. |   |.       | | .. .|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalil..tnnttappstreishyqft

EWYSHSCPFSNALLEFRRRVRLVVGniiKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEEC--FNVFGYLKKLRQSRKGLVENVEQYKFIYD
 |  .. |    .. |    | |     | |..   |..|||||| | .||....|  .   ||      ..|   |.|||.| |..  ...|.|||.
swkekttpnvalfvgfvvasrevsk...kyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 169-364 1.1e-23 78.5 In-house 6-198 (199) alignment 
Range on Protein: 169-364
Range on HMM: 6-198/199.0
AYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTFRLykMNEKQEVTDERLILQFHYT
 ||.|| |. ||.  .|.|||.     |||.       ..    |||       .|| . .        ... | .. |   |.       | | .. .|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitalil..tnnttappstreishyqft

EWYSHSCPFSNALLEFRRRVRLVVGniiKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEEC--FNVFGYLKKLRQSRKGLVENVEQYKFIYD
 |  .. |    .. |    | |     | |..   |..|||||| | .||....|  .   ||      ..|   |.|||.| |..  ...|.|||.
swkekttpnvalfvgfvvasrevsk...kyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
0051082 (Phosphotyrosine protein) phosphatases II 153-367 1.2e-23 78.8 In-house 3-150 (151) alignment 
Range on Protein: 153-367
Range on HMM: 3-150/151.0
SDYVNASYVDSLlkpnaYIVTQGPVEetvqAYWRMVWQENISAIVMLTKTFDFAkvMCHQYWPPNMevheqygdifinivreeqlanfhirtfrlykmne
||| |.|||..      .....|| .    ..........|..||.|....  .  .|..|.| .                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

kqevtdeRLILQFHYTEWYSHSCPFS-NALLEFRRRVRLvvgniikdeddM-RGPILVHCSDGGGRSGVYMSIDANLeLAeeeecFNVFGYLKKLRQSRK
       . .|..... |  ...| | .|.||| . ..            .  ||.||||| | ||.|. . ..  | |      ....  |. .|..| 
.......ievlhipildwpdpglplsfdavleflellld...........kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrp

GLVENVEQYKFIYDTLE
|.|   .|. |..  |.
gvvqpnqqflfqlfall
subfamily_PTPN13_pd Subfamily PTPN13 417-672 4e-23 77.1 In-house 26-267 (273) alignment 
Range on Protein: 417-672
Range on HMM: 26-267/273.0
IGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGnaftdYINSVFVDGYT--KPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQS-QQYP
. .|  |....|..|||    .| |. |  | .  |     |||. ..      .  |||..  |. .|  .|| .|..|... .... .   .   .  
ldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

SFWPNKSKME-KYGPVFSVHYVmskSYTNIKqwEFKINKkiVSLTEMMAgvkAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRNkvDYGPVCV
 .||.. . . |    . |. .    ... .  .|....  . .... .   . .| |. .... ||  |.||||...|. ..  |   ..  | ||. |
rywPesknkklkvsnrlevell...kvqkld..gfvvra..lavkdses...gesrevahlnfvkwP.dhgvPssaaellqfvaevrrlqt..dagPivv

VSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLH
    |  |.|.. . .. .. . .  |.|| . |...|. |  .|     | ..|  .|.
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 132-372 4.4e-23 76.7 In-house 53-273 (288) alignment 
Range on Protein: 132-372
Range on HMM: 53-273/288.0
PKCipyDYNRVVLEkvgglQDSD-YVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIfIN
|.|   |. || |.      |.| |..|  | |   ..  | .| |.. |.. .|.|. ....  ||||..  .  |    .|.| ..  . ..| .  .
prc...ditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl.ct

IVREEQlANFHiRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPFSnalleFRRRVRLVvgNIIkdeDDMRGPILVHCSDGGGRSGVYMSIDANLELA
.|.... |. . .. ..  .. ..|. .. .. . |. ||  .. | .     .   .||.  ...    ... ||.||.| | ||.|  . |   || .
vvkkkr.adid.klvkvsllriskegeekvivkilhlleWdddgvPen.....ylsplrll..evl...kslqkPivvhssaGvGrtgtlililialesl

EEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIIC
  ..   .   |.|||..|.  ..   || ...  . |... 
rlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
0049772 (Phosphotyrosine protein) phosphatases II 426-678 4.9e-23 77.8 In-house 44-284 (314) alignment 
Range on Protein: 426-678
Range on HMM: 44-284/314.0
ADNREKNRDVLCVPPDnFRPYLTSFQGNAfTDYINSVFVDGYtkpREYIVTEWPMKHTLGEF----------WSLV--YDQECSAVVV------------
  ||.|||   ..| |  |  | .. ..  .||||. .|||.   . .|.|..|...|.  |          |..|  .|. .  .|             
flnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------LCQPPSQSqqypsfwpnkskmekygpvfsvHYVMSKSYTNIKqwefkinkkivslTEMMAGVKAPTRTVQLFQLtCWPMgHKVPsSTNSLV
         |.... .                        .   . . ..|             .|.  . . . . ......  .|  . .| ... . 
LdaAlgKtpllildgng......................neptaadlellk.............eelydpelferlgikylri.pvpD.gsap.lledfd

YLMNMVEIWrnkVDYGPVCVVSPDGRSRAGVYCAANACIEQViqhgEVDVFQAVKTVRRHRP-----QLVENMTEYKYCYDLVLHYVLHFL
 .....| .    . ||| |   .|..|.|....|  .. .      |.. .|.. ||. ||      ..|.  .| .... .|.|.  ..
eflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 109-366 6e-23 75.7 In-house 37-281 (302) alignment 
Range on Protein: 109-366
Range on HMM: 37-281/302.0
AAKVESNTCRhaLKKNNLEKNQNPKCIPYDYNRVVLEKvgglQDSDYVNASYVDSL-LKpNAYIVTQGPVEETV---QAYWRMVWQENISAIVMLTKTFD
. ||. . |.  . |.||.|||....  .| |.| ||.    .  .||||| |.   |. .  |..| |. ...   . .||||.||.|  .|.| .. .
tmkvdlekCk..afkknlkknqsedvpildsnlvklea....epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeee

FAKvMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHiRTFRLYKMNekQEVTDERLILQFHYTEWYSHSCPFSnalleFRRRVRLVVGNiIKDEDDMRG
  |   ....| ... ...||..|.|. . |.  . .   . .  .   .....  |.   . | | ... | .     . . .. ...   . . .   
lkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlP..egcsnsvlanvyvltnWkqkkvpvk.....yaeliktaakv.fakkikade

PILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL
....    | || |. ..  . .|  ....  |.   .|..|. |   |....|| ..| .|
ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 156-359 3e-22 73.7 In-house 78-270 (301) alignment 
Range on Protein: 156-359
Range on HMM: 78-270/301.0
VNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQLANFHIRTfRLYKMNEKQE
. | ....  .|. .|.||||...| . .| |. | ..  ||||... .  . .|..| | ... . . |   |.|. .|.. | .|   |  ....  .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkisk.rtlevedstg

VTDERLILQFHYTEWYSHSCPFSNALLefrrrVRLVvgNIIKDEDDmrgPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVEN
  . | .. . |.||  .  | | | |       |.  ...|. ..   ||.||||.| |||  ... .      | .   ..   ||.||. |   | .
kfatrtvthyqysewtdrgvPkshael.....fdlm..elvkksek...PivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqt

VEQY
..| 
nsql
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 125-372 3.4e-22 73.7 In-house 37-272 (285) alignment 
Range on Protein: 125-372
Range on HMM: 37-272/285.0
NLEKNQNPKCIpyDYNRVVLEKvgglQDSDYVNASYVDSLLKP-NAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQ
.|..  . .||  .  ||||..    .| ||. ||..    |  ..|| ||||. ||.  .|.|..||.|. ..||   |.     |  |.| ..    .
dlnryadvrci..eetrvvlkn....hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGDIFI--NIVREEQLANFHIRTFRlykMNEKQEVTDERLILQFHYTEWYSHSCPFSNAllefRRRVRLvvGNIIKDEDDMRGPILVHCSDGGGRSGVYM
.|   |    ..|| .|   . ..    . . .. . | | ...    |.       .|    |  . |   . .|  .    || |||| | ||.  ..
fgkyeitlteckeeaiagtilnalt...vintedasseplymnhvqvpwwpdqlapeda....rpmiel..ykwvkkvnpkekpicvhcsagvgrtatfv

SIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIIC
 ||       |.   ...  ....|  |   |..  |. |.|  | |..| 
gidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig
0043147 (Phosphotyrosine protein) phosphatases II 455-668 2e-21 71.9 In-house 4-155 (172) alignment 
Range on Protein: 455-668
Range on HMM: 4-155/172.0
FTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPpsqsqqypsfwpnkskmekygpvfsvhyvmsksytnikqwefkinkkiv
..||||  ..|.| .|...|.| .|. .|| .|| ..... ....| |..                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

sltemMAGVKAPTRTVQLFQLTCWPmGHKVPsSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIeqviqhGEVDVFQAVKTVRRHRP
     .   .  .|..  .. . ||  | || ... |  ... .. . .. . |||.|    | .|.|. .||  ..        .....||..||..||
.....lydpellerlgiqylylpwp.Dhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRp

QLVENMTEYKYCYD
. |.|   |...|.
gavqnpsqyrflyy
0051429 (Phosphotyrosine protein) phosphatases II 455-678 4.4e-20 67.9 In-house 3-229 (272) alignment 
Range on Protein: 455-678
Range on HMM: 3-229/272.0
FTDYINSVFVDGYTK---PREYIVTEWPMKHTLGEFWSLvYDQECSAVVVLCQPPSQSQQY-PSFWP----------NKSKMEKYGPVFSVHYVMSKSYT
...|||  .|.||..   |. .. .  |...|  .|| | ... ....| |...  . ..  . .||          . | ..     ..| ... . ..
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

NIKQWEFKINKKIVsltemmagvKAPTRTVQLFQLTCWPMGHKVPSStnslvyLMNMVEIWRNkvdYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEV
..  .|. . ...             .|.| ... | ||  .  ...      | ...|. ..    ||| |    |..| |...|.  ....|  .  |
dyilrellltllls.........agearevmhlhytdwpdhgvpqea......llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletiv

D--------VFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLHFL
|        ...||. .|..||. |.. . |...|. .|...  .|
ddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 427-671 4.5e-20 66.9 In-house 2-236 (237) alignment 
Range on Protein: 427-671
Range on HMM: 2-236/237.0
DNREKNRDVLCVPPDNFRPYLTSFQGNafTDYINSVFVDGYT-KPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPS-QSQQYPSFWPNKSKMEK
.|. |||    |  |  |  |    ..  .||||. ...|.   |..|| .. |.. .  .|| .|... || .|.|      . ..   .||.  . . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGpVFSVHYVMSKSYTNIKQWEFKINKKIVSLtemmagvkaPTRTVQLFQLTCWPMgHKVPSSTNSLV-YLMNMVEIWRNKVDYGPVCVVSPDGRSRAGV
|| |..|     . ...     . . |..              | .. .|.|.||  . ||  | .|. .  |...  .   . ||  .    |  |.|.
yg.vltvslkkkeefsdytvrslllskrltlk.........evrlihqyqftswpd.rgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgi

YCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVL
.   .| . |  ..  ||... |...   || ...   .| . .. .|
flvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 399-676 7.6e-20 66.1 In-house 16-279 (307) alignment 
Range on Protein: 399-676
Range on HMM: 16-279/307.0
NEYQAEYDQICKQTPRFTIGDCAGGhradNREKN--RDVLCVppDNFRpYLTSFQGNAfTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQEC
.. . |. ...|.||     ..       | .||  .|| |.  |. |  .  |.| | .||| . ..   .||. .|... |.. |  .||... ... 
qalvdefrvlakktpegvtveafsa....ntdknryqdvkcq..dkgr.ivvkfdgla.sdyihanylgiaikpkkficaqgplentqysfwamaiqekv

SAVVVLCQPPSQSQ-QYPSFWPNKSKMEKygpVFSvHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLM
 .|..||.    .. .   .|| .   ..   ||. .   . | .|.   ..  ..... .|..       .||.| .| . ||  . ||    . . |.
esvimlckvielakikceqywpleegqkl...vfg.eapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwp.drgvpqinltainll

NMVeiwrnKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGE-VDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLH
. |     . |  || |    |  |.|   |     ...|.  .  |. . |. .| .|.  ...  .| | . ..|.| | 
eav.....rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 97-366 8.3e-20 65.7 In-house 19-283 (305) alignment 
Range on Protein: 97-366
Range on HMM: 19-283/305.0
KFPVLYKLEFQTAAKVESNTCRHALKKN-NLEKNQNPKCIPYDYNRVVLekvGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISA
| |.  . ||..  ...     .|.|.  . .||.       | ||| |    |    .|. | || .  .|. .| || |.|.|   .| | .|... |
kgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkvea

IVMLTKTFDFAKVMCHQYWP----PNMEVHEQYGDIFINIVREEQLaNFHIRTF-RLYK--MNEKQEVTDERLILQFHYTEWYSHSCPFSN-ALLEFRRR
| || .  .     |..|..    . .| .|.   | . .   ..| .|.  .  .. .  .  .   .. | . ..|. .|     | .. |.||.  .
ifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtl.kfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek

VRlvvgniikdedDMRGPILVHCSDGGGRSGVYMSIDANLE-LAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTL
 |             .||| |||| | ||.|  . ..  |. | . .   .    |.|.|. |.  ..  .|| |... .
ar...........pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi
subfamily_CG42327_pd Subfamily CG42327 127-280 1.1e-19 65.3 In-house 30-181 (319) alignment 
Range on Protein: 127-280
Range on HMM: 30-181/319.0
EKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDSLL-KPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNM--EVHEQ
.|..  . .|    ||||...|  . . |..||||      || || .| . |..  ..||.||. .   || ||. ..    .| .|.|..   . .. 
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

YGDIFINIVREEQLANFHIRTFRLYKMnEKQEVtdeRLILQFHYtEWYSHSCPFSNA
|||| . .   |   .. | |. | .. .|.|    | .  . | .|     | ..|
yGdilvtlkgrevkdryaistlllkrv.dkees...relthywy.kwleaevPaeea
0046846 (Phosphotyrosine protein) phosphatases II 453-673 1.2e-19 66.2 In-house 9-172 (176) alignment 
Range on Protein: 453-673
Range on HMM: 9-172/176.0
NAFTDYINSVFVDGYtkprEYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQP-PSQSQQYPSFWPNKSKMEKygpvfsvhyvmsksytnikqwefkink
. . ||||  ...|.     .|.| .|. .|| .|. ..... ..||| |...   .. . | .||   |..                            
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

kivsltemmagvkaptrtvqlfQLTCWPMG-HKVPSStNSLVYLMNMVEIWRNKvDyGPVCVVSPDGRSRAGVYCAANacieqVIQH-GEVDVFQAVKTV
                      |  ..|.  | ||.. . |  |..... .... . ||| |    |..|.|...||       ...   ..|..|...|
......................qylhlpwpDhgvpdl.elllellefirealke.g.gpvlVHCsaGigRtgtlvaay.....llelekglsveealalv

RRHRP-QLVENMTEYKYCYDLVLHY
|..|| . |...  |...|. .|..
reqRplgavqtpeQyrflyefelll
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 464-673 1.5e-19 64.7 In-house 229-437 (440) alignment 
Range on Protein: 464-673
Range on HMM: 229-437/440.0
VDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQsqQYPSFWPNKSKMEKYGPvFSVHYVMSKSYTNIKQ--WEFKINKKIVSLTEMMa
..||.|   .| |. |.  |. .|| ||.| . |....| |   .      .|| ...   .|| |.| .  |.    .|    |.| ....  . ..  
fegyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk..tcsiywpvntrsvtfgp.ftvghkgsenmnrvkvrtlelkykeevheirqfe.

gVKA-PTrTVQLfqlTCWPMGHKVPSSTNSLVYLMNMVEIWRNK-----VDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQ
 |.. ||  .|           ..  .   |.  .. .|| |        |  |. |    |   .||.|.   |.||. . | .|||| .. .|  ||.
.vqtwpt.wiqs...dgvqsqeqcmdavlqlmdylrkceiqrsteqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpn

LVENMTEYKYCYDLVLHY
.|  .|.|  || |. |.
fvptltdyllcykllthh
0049260 (Phosphotyrosine protein) phosphatases II 463-668 3.2e-19 64.5 In-house 1-144 (152) alignment 
Range on Protein: 463-668
Range on HMM: 1-144/152.0
FVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQYPSFWPnkskmekygpvfsvhyvmsksytnikqwefkinkkivsltemmag
|.||| .|.|.| |..|. .|| .|| ..... ....|.|...      .  ...                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

vkaptrtvqlFQLTCWPMGHKVPSSTNSLVYLMNMVEIWrNKVDYGPVCVVSPDGRSRAGVYCAANACIeqviqhGEVDVFQAVKTVRRHRPQLVENMTE
            | ..   | ||...  |  |. ..|.. .. . ||| |    | .|.|...||  ..        |....||. ||..||. |.|   
..........qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgq

YKYCYD
....|.
lrflye
PTPc_DSPc_SM00012 569-671 3.8e-19 64.2 In-house 1-104 (105) alignment 
Range on Protein: 569-671
Range on HMM: 1-104/105.0
TVQLFQLTCWPMGhKVPSSTNSLVYLMNMVEIWRNKVD-YGPVCVVSPDGRSRAGVYCAANACIEQVIQH-GEVDVFQAVKTVRRHRPQLVENMTEYKYC
||. .. | ||   .||....|.. |.. |. ..|| .  .||.|.. .| .|.|...|.  ...|. .. .|||.|| || .|..||..|.. ..| ..
tvkhyhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YDLVL
|. .|
yrall
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 110-234 4.4e-19 63.2 In-house 38-159 (310) alignment 
Range on Protein: 110-234
Range on HMM: 38-159/310.0
AKVESNTCRHALKKnNLEKNQNPKCIPYDYNRVVLeKVGGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVM
|| .|    .| || .. ||.    .  |  || | |.   .  ||. | || .    ...|..|||.. |.  .|||..||   .|..| |. .  .  
akqdssltyeaykk.ymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpk

CHQYWPpNMEVHEQYGDIFINIVRE
|  |||  . | | || | .  . |
cvgywp.slgvtetygcirvtnlse
subfamily_eak_pd Subfamily eak 115-374 6.6e-19 62.5 In-house 42-309 (332) alignment 
Range on Protein: 115-374
Range on HMM: 42-309/332.0
NTCRHALKKNNLEKNqNPKCIPYDYNRVVLEKVgGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYW
 . . . . .....|   | .|||.. | |     |    |.||| ..     . ||.|  . |. | |.|.|| ...  |||.| .  .       .|.
lsisetarleavnrn.vvkivpydrylvrltss.qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PPNMEVHEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEVtderliLQFHYTEWYSHSCPFSNALLEFRRRVRLV-VGNIIKDEDD-MR---------
| .     ..| . ..     . .... | . | | ||  .|      | ...  |   . |  . .| .|. .. | | ..|  ... ..         
pdktreelkfGildverkefvkrniletrllelskGnethrv......lhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyiht

----GPIlVHCSDGGGRSGVYMSIDANLELAEE--EECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGK
     || . .. |. |.||.. ||  ..| ..  .. . |  .. | .. |.  |    |. |||. . ...   .
ppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 124-371 1.7e-18 61.3 In-house 46-280 (303) alignment 
Range on Protein: 124-371
Range on HMM: 46-280/303.0
NNLEKNQNPKCIPYDYNRVVlekvggLQDSDYVNASYVDSLLKpNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHeQ
.|..||.    |  |. .|       | || |. |||..   . .  |.|| |.  |   .|.|. ....  ...|    .. |.  .  .| | .   .
knmdknrfvdvicldhskvk......lsdssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl.k

YGDIFINIVReeqLANFHIRTFRLYKMNEKQEVTDERLILQFHYTEWYSHSCPfSNALLEFRRRVRLVVGNIiKDEDDMRGPILVHCSdGGGRSGVYMSI
. . .| .     . .  .      |.    . .   ..   || .|   | | |..  .| ...  .   . .   | . .. .  | | ||.| .  .
feersirvge...fkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsip.sdgspkfvkqiwqlqsvl.rkysdstptvymsls.gcgragtfalf

D-ANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHII
. | | | .|. ....   |...|. |   |.|. |. ..|  | ||..
etahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
0048076 (Phosphotyrosine protein) phosphatases II 225-367 8.8e-18 59.8 In-house 14-140 (145) alignment 
Range on Protein: 225-367
Range on HMM: 14-140/145.0
GDIFiNIVREEQLANFHIRT-FRLykMNEKQEVTdeRLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGNiikdeddmRGPILVHCSDGGGRSGVYMS
|..  . .. |.|....|.| ..|  ..|.. ..  ||..|..|. |  |..| . . |||| . .. .. .         ||.||||| | ||.|... 
gslp.taldlellkdlgittvlnl..tselelle..rlgiqylylpwpDhgvpdllellleflefieealke........ggpvlVHCsaGvgRtgtlva

IDANLElaeeeECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLE
..  |.     . ....  |...|. | | |.|..|..|.|. ..
aylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 258-411 9e-18 58.8 In-house 87-235 (440) alignment 
Range on Protein: 258-411
Range on HMM: 87-235/440.0
DERLILQFHYTEWYSHSCP-FSNALLEFRRRVrlvvgnIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENV
. | . |.||  |  .. | |.  .|.. . |         .|    ||.||||| | ||.|| ...|. |  |.  .  ..| ... .|..|  .|.  
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdv......nesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtp

EQYKFIYDTLEEHIICGKTWFPVSELSDRLKAKARRNSGTKMNEYQAEYDQICKQ
||| |..... | ..|| |     ....|..     |  |  .  | |..   |.
eqyafvheavlegllcgdtliledditerveqiqwpnphtdksplqqefegyskk
0044763 (Phosphotyrosine protein) phosphatases II 439-672 4.9e-17 57.6 In-house 1-169 (178) alignment 
Range on Protein: 439-672
Range on HMM: 1-169/178.0
PPDNFRPYLTSFQGNAFTDYINSVFVDGYtkpreYIVTEWPMkhtlGEFWSLVYDQECSAVVVLCQPPSQS-QQYPSFWPNKSKmekygpvfsvhyvmsk
| |. |  |....|   .|||| ......     .... .|.     ... |.... ....| |...     ....  || .                  
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

sytnikqwefkinkkivsltemmagvkaptrtvqlFQLTCWPM-GHKVPSSTNSLVYLMNMVEIWRNkVDYGPVCVVSPDGRSRAGVYCAANACIEQviq
                                   .|  ..|. .|.||...  .  .....| ...  . ||| |    |..|.|. .||  ....   
...................................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl...

hgEVDVFQAVKTVRRHRPqLVENMTEYKYCYDLVLH
   .....|.. ||..||  |.|.  ....|.. |.
..glsleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 567-674 1.3e-16 55.0 In-house 277-385 (392) alignment 
Range on Protein: 567-674
Range on HMM: 277-385/392.0
TRTVQLFQLTCWPM-GHKVPSSTNSLVYLMNMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKY
. ||  .|.  ||  |    | . ||. |.  |    |.     . |    |  |.||.|.|  || |. .   ||.||.|| .|  | | |.   || .
shtvtqyqfhgwpkhgsdqqsgarsllkliravkgstnskkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeeyaf

CYDLVLHYV
 ||..  |.
vydvireyl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 471-677 2.1e-16 54.2 In-house 90-288 (302) alignment 
Range on Protein: 471-677
Range on HMM: 90-288/302.0
REYIVTEWPMKHT---LGEFWSLVYDQECSAVVVLCQPPSQSQQYPSFWPNKSkmEKYgpvfSVHyvmSKSYTNIKQWEFKINKKIVSLTEMMAGVKAPT
|. |..  | . .   . ||| .|.....  ||.| ..   ..    ..|.||  ..|    . .    | . |... | . ..|     |..    . .
rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkks..gdy....key...gkmfvNnrkVekaeeektryviEvlPegcsns

RTVQLFQLTCWPMgHKVPSSTNSLVYLMNMVeiWRNKVDY-GPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYC
  ...  || |.  .||| . ..|.  .  |  . .|..   .. .||  |  |||.  .. . .|.. .. |. . . ||..|  ||. |.... |   
vlanvyvltnWkq.kkvpvkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvsl

YDLVLHYVLHF
|  .| |... 
yialllyikkk
0048179 (Phosphotyrosine protein) phosphatases II 235-364 2.4e-16 55.2 In-house 23-139 (144) alignment 
Range on Protein: 235-364
Range on HMM: 23-139/144.0
EQLANFHIRTfRLYKMNEKQEVTDERLILQFHYTEWYSHSCPFS-NALLEFRRRVRLVVGniikdeDDmrGPILVHCSDGGGRSGVYMSIDANLelaeeE
|.|....|.|  .  ..|      || ..|.... |  |..| . . |||| . .. ..       ..  ||.||||| | ||.|... ..  .     .
ellkklgitt.vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale......eg..gpvlVHCsaGvgRtgtlvaaylmk.....k

ECFNVFGYLKKLRQSRKGLVENVEQYKFIYD
. ....  |. .|. | | |.| .|..|...
lglsleealalvrsrrpgavpnpgqlrfLle
subfamily_ptpA1_pd Subfamily ptpA1 420-631 7.3e-16 52.9 In-house 39-253 (418) alignment 
Range on Protein: 420-631
Range on HMM: 39-253/418.0
CAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGyTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQ-QYPSFWPN
 . | .  |  |||    .| .  |  |   | .  .||||. ..|| . |...|.|. |.  |. .|| .|... |  .|.| .   . . .   .||.
tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpe

KSKMEKY---GPVFSVHYVMSKSYTNIKQwefKINKKIVSlTEMMAGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRNKV-----DYGPV
.   |..   |    |    |    .. |     ...|..  ..   ..  || .  .|   ||  |..|  |. .  |.  .   .|..        |.
qiggeqfsiygngnevfgtysvelveviq...dpereiit.rnirltfegetrditqyqyegwp.dhnipdhtqpfrqllhsitnrqnqiipssdrnvpi

CVVSPDGRSRAGVYCAANACI
 |    |  |.| .|.|   .
ivhcsagvgrtgtfctavimm
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 138-363 2e-15 51.7 In-house 31-252 (290) alignment 
Range on Protein: 138-363
Range on HMM: 31-252/290.0
DYNRVVLEKVGGLQDSDYVNASYVDsLLKPNAYIVTQGPVEET-------VQAYWRMVWQENISAIVMLTKTFDFAK----VMCHQYWPPNMEVHEQYGD
  .||||.  |    .||. |..|    .  . |.|| | |..       .. .| |. ||..  .||| .  .  .    . | .| | ... . ....
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

IFINIVREEQLANFHIRTFRLyKMNEKQEVTderlILQFHYTEWYSHSCPFSNALLefrrrvrlvvGNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDAN
. ..    |.  .. .|.  . | ....| |    .    . .| . . . .. .|           ..|.     . |..||| ||  || .  .|.  
ltvkCkskekeddvetRelvv.kfddeeeft....vtHsllkgWnklnvqedtktl..........lsliqkvkasktpvivHcvdGiSrsAalaaiilg

LE-LAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIY
   .|| .. ...   ||.||. |  .. . ... |. 
yQkiaetsgsvkledvlkalrkqralaitsalelafvd
0051082 (Phosphotyrosine protein) phosphatases II 455-669 2.7e-15 51.7 In-house 2-148 (151) alignment 
Range on Protein: 455-669
Range on HMM: 2-148/151.0
FTDYINSVFVDGYtkpreYIVTEWPMKhtlgEFWSLVYDQECSAVVVLCQPPSQSqQYPSFWPNKSkmekygpvfsvhyvmsksytnikqwefkinkkiv
..||||  .|.|.     .... .|.     .|. |.... ....| |....     .|...|. .                                  
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg..................................

sltemmagvkaptrtvqlFQLTCWPM-GHKVPSSTNSLVYLMNMVEIWRNkVDYGPVCVVSPDGRSRAGVYCAANACIEQviqhgeVDVFQAVKTVRRHR
                  ......|. ....|.   |.  .....|. ..  . ||| |    |..| |. .|.  ....      |....|.. .|..|
..................ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkr

PQLVENMTEYKYCYDL
| .|  .... ...  
pgvvqpnqqflfqlfa
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 127-216 3.4e-15 50.6 In-house 49-152 (350) alignment 
Range on Protein: 127-216
Range on HMM: 49-152/350.0
EKNQNPKCIPYDYNRVVLE--------KVGGLQDSDYVNASYVDSL-----LKPNA-YIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQ
 ||.    .||. .|| |.        |   |. .||.||.|.         .|.  || ||.|. .||. ..... . ..  |..||. ...    |..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPP
||. 
YWqe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 110-245 8.9e-15 49.0 In-house 81-209 (244) alignment 
Range on Protein: 110-245
Range on HMM: 81-209/244.0
AKVESNTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKvgGLQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDfakvm
 . . .  . |.. ||  ||..   .|.|.||| | |  |     |.|||.|  | .   ||.|| |. .|   .|.|. .  .  .|.|    .     
irpdpsvmkdafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.....

CHQYWPPNmEVHEQY-GDIFINIVREEQLANFHIRTF
  .|||   |  | |  || . .   ... | .   .
edeywpds.eplewyeeditvtltdrdefknikasnl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 427-670 9e-15 49.5 In-house 7-237 (239) alignment 
Range on Protein: 427-670
Range on HMM: 7-237/239.0
DNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGY-TKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQ-PPSQsqqypsfwpnKSKMEK
 |. |||    |  |  |  |  .  . ..||||. ..  |   |. || |.  .. . |.|| .....    .|.|      .          | |  .
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltgliegh..........kkkchq

YGPVFSVHYVMSKsyTNIKQWEFKInKKIVSLTEMMAGVKAPTRTVQLFQLTCWPMgHKVPSSTNSLVYLMNMVeiWRNKV-DYGPVCVVSPDGRSRAGV
| |  . .|.  .    ... |      |.    |    ..  | |  ...| ||  . ||  . ... |   .   .. .    |  .    |  |.| 
ywpdstskycnlr..vtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpd.kgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtga

YCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLV
.   .| . |  ..  ||.|. ||..|  ||..|.   .| . .  |
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 427-670 9.7e-15 49.4 In-house 6-236 (239) alignment 
Range on Protein: 427-670
Range on HMM: 6-236/239.0
DNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGY-TKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQ-PPSQsqqypsfwpnKSKMEK
 |. |||    |  |  |  |  .  . ..||||. ..  |   |. || |.  .. . |.|| .....    .|.|      .          | |  .
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltgliegh..........kkkchq

YGPVFSVHYVMSKsyTNIKQWEFKInKKIVSLTEMMAGVKAPTRTVQLFQLTCWPMgHKVPSSTNSLVYLMNMVeiWRNKV-DYGPVCVVSPDGRSRAGV
| |  . .|.  .    ... |      |.    |    ..  | |  ...| ||  . ||  . ... |   .   .. .    |  .    |  |.| 
ywpdstskycnlr..vtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpd.kgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtga

YCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLV
.   .| . |  ..  ||.|. ||..|  ||..|.   .| . .  |
flvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_egg_pd Subfamily egg 426-674 1.1e-14 48.9 In-house 38-270 (307) alignment 
Range on Protein: 426-674
Range on HMM: 38-270/307.0
ADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQpPSQSQQYPSFWPnKSKMEKY
..|.|| |.      |  |  |   .|    |.| .  |.|     |.|... |.| |  .|| .|. .|.  .|.|     .|.. . .|| |.. .  
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmlts.rkeserceyywp.kaesdsl

GPV-FSVHYVMSKSYTNiKQWEFKINKKIVslT--EmmagvkaptrtVQLFQLTCWPMGHKVpsSTNsLVYLMNMVEIWRNKVDygPVCVVSPDGRSRAG
  |  |..    | . .  .  |.. |  .     .            .   |  |    .   |.. . . ....   ||     || | . .| |.|.
vtvpGslrienlkvdsk.adplfrvtklkl..vGgd...........deerflehwqgdvnn..ssd.vysplrvlrklrnlsk..pvvvqdilGvskaa

VYCAANACIEQVIQHG--EVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
.  |..  . ....       | .||. .|..|.  || .  | . | ||| ..
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 113-370 1.5e-14 48.5 In-house 33-276 (312) alignment 
Range on Protein: 113-370
Range on HMM: 33-276/312.0
ESNTCRHALKKNNLEKNQNPKCipYDYNRVVLEkvGglQDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQ
    |   || ..|..  | .|  .|  |  |   |  ..  |. | .|    ||. ...||||.|.|.  .|...     ..|..|.   . .   | .
sdsectaflkfkdlnrypniqc..wdrgrftla..g..denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcak

YWP-----PNMEVHEQYGDIFINIVREEQLANfHIrTFRLYKMNEKQEVTdERLILQFHYTEWYSHSCPFSNALlefrrRVRLVvGNIIKDeddmRGPIL
|        ..| |  | .   .|    .  . .| | |. |.  |     |  . .. .. |  |  | |          ||.   . ||    . |..
yisdivgfvdledhrvyteycteieiggkskd.ki.thrvlkvvvkatgq.esklnhyqwaswpdhgmpdscdt.....alrll.savkkd....kkpvi

VHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHI
 ||| | ||.|  . |.. .         ||   .  ||. |   |. . || .   .. | .
ahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 462-659 1.7e-14 48.3 In-house 81-266 (301) alignment 
Range on Protein: 462-659
Range on HMM: 81-266/301.0
VFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQ-YPSFWPNKSKmekygpvfsvHYV-MSKSYTNIKQWEFKINKKIVSLT--
 ...   .|. .|.|  |.| |  .|| ..   .   .|.|.|   . ..   .. | | .          . . . .   .||. |. .||||.  |  
nwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis..........ekldigrfkikiknkelilnkkiskrtle

EMMAGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVeiwrnKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLV
   .  | .||||  .| . |.  . || |   |  ||..|     |    |. |  ..|  |.  . ...    .|  . .... .|.| .| || . |
vedstgkfatrtvthyqysewt.drgvPkshaelfdlmelv.....kksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngv

EN
 .
qt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 433-673 3.1e-14 47.3 In-house 63-282 (290) alignment 
Range on Protein: 433-673
Range on HMM: 63-282/290.0
RDVLCvpPDNFRPYLTSfqGnAFTDYINSVFVDGYTKPreYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQ-QYPSFWPNKSkmekyGPV--F
.|| |   |  |  |    |    ||. . .|.|   .  .|.|. ..| |  ..| .| ... .|.|.||.   . . .   ..|.|.     | |  |
kdvvc..ndktrvilkd..G.ydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke.....Gevltf

SVHYVMSksyTNIKQWEFKINKKIVSLTEMMAGVKaptRTVQLFQLTCWPMgHKVPSSTnslVYLMNMVEIWRNKvdYGPVCVVSPDGRSRAGVYCAANA
    |.    .. .. . .| ||..|. .. .| .     .. ... .||  . |. ||   . |. .. | |.    ||| |    |  |.| . | ..
Geitvlc...seeddkdaniikktlsvrdkdsGke...hklkhlkikswpd.ksvalst...lallrtlrilrka..sGpvvvhcsaGiGrtGtfvaiev

CIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHY
... ...  |.|. . |...|. | . |.  ..|    ...|..
glqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 458-675 1.1e-13 45.9 In-house 69-272 (288) alignment 
Range on Protein: 458-675
Range on HMM: 69-272/288.0
YINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQ-----QYPSFWPNKSKMEKYgpvfsvhyvmsksYTNIKQWEFKINKk
||..  |     .|  | .. |.. |..|.| .. ...   .|.||.   . .      .||   .| .. ..              | .|.    |.| 
yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl.............ctvvkkkradidk.

IVSLTEMMAGVKAPTRT-VQLFQLTCWPmGHKVPSSTNSLVYLMNMVeiwrnKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRR
.|... .    .  ..  |.   |  |.  . || .  | . |....     |    |. | |  |  |.|        .|..  .  . . . ..  | 
lvkvsllriskegeekvivkilhlleWd.ddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklre

HRPQLVENMTEYKYCYDLVLHYVL
.| . ..    | | . .||...|
erfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 168-384 2.1e-13 45.0 In-house 35-229 (255) alignment 
Range on Protein: 168-384
Range on HMM: 35-229/255.0
NAYIVtqgpveeTVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVReeQLANFHIRTFRLYKMNEKQEVTDErlILQFHY
| |..       ||....... | . . .|||.   . ... |..|.| . . . .. |. .   .    |.  .|| ..  .  ..  |..  .  ..|
nlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkktht..vkhysy

TEWYSHSCPfsnallEFRRRVRlvvgNIIKDEDDMrGPILVHCSDGGGRSGVYMSIDANLE-----LAE-EEECFNVFGYLKKLRQSRKGLVENVEQYKF
. |  .  |      |  | ..    ||.|   |   ...|||| |.|||  .. ..         | . |   ..    |..||..||. ...  |  |
kGWieknaP......elareil....nilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf

IYDTLEEHIicgktwFPVSELSD
   .. . .      || .|| .
silmvldlv......fpkgelea
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 428-667 2.1e-13 44.5 In-house 52-283 (310) alignment 
Range on Protein: 428-667
Range on HMM: 52-283/310.0
NREKNRDVLCVPPDNFRPYLTsFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQY-PSFWPNKSKMEKYG
.  |||    |  |. |  |.  .   . ||| . .|        .|... |..||. .|| ..... . ....||.   . .    ..||     | ||
ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

PVFSVHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGVKAptRTVQLFQLTCWPMgHKVPSSTNSLVYLMNMveiwrNKVDYGPVCVVSPDGRSRAGVYCA
 .    .  |    .| .    .    | . |  | .|     |.| .   ||    ||      |    .      .| .||. |    |. | .| .|
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlke..lrvslikwpnwpd.rgvpdekchtvpqrll.....aqvrhgpcvvhcsagkdrlyvvva

ANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCY
 .  |... .  .||. . .  ....| . ...  .| .  
lklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 471-668 3e-13 44.4 In-house 5-198 (199) alignment 
Range on Protein: 471-668
Range on HMM: 5-198/199.0
REYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQ-QYPSFWPN-KSKMEKYGPVfSvhyVMSKSYTNikQWEFKINKKIvsLTEMmAGVKAPTR
| ||.|. |...|. .|| .|..     .|.. .   . . .|| .||  .|   ||| . |   | .|. |   . .. |   |  ||.  .     ||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygsl.s...vttktitt..kpdytitali..ltnn.ttappstr

TVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWR--NKVDYGPVCVVSPDGRSRAGVYCAANACIEQV--IQHGEVDVFQAVKTVRRHRPQLVENMTEYK
 .  .|.| |   .  |  .  . ...   |. .  ..    || |   ||.  .||. | .  .      .   ||.|.  | .|. |  ..  .  |.
eishyqftswk.ekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn

YCYD
. |.
fiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 471-668 3.3e-13 44.3 In-house 4-197 (198) alignment 
Range on Protein: 471-668
Range on HMM: 4-197/198.0
REYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQ-QYPSFWPN-KSKMEKYGPVfSvhyVMSKSYTNikQWEFKINKKIvsLTEMmAGVKAPTR
| ||.|. |...|| .|| .|..     .|.. .   . . .|| .||  .|   ||| . |   | .|. |   . .. |   |  ||.  .     ||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygsl.s...vttktitt..kpdytitali..ltnn.ttappstr

TVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWR--NKVDYGPVCVVSPDGRSRAGVYCAANACIEQV--IQHGEVDVFQAVKTVRRHRPQLVENMTEYK
 .  .|.| |   .  |  .  . ...   |. .  ..    || |   ||.  .||. | .  .      .   ||.|.  | .|. |  ..  .  |.
eishyqftswk.ekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn

YCYD
. |.
fiyq
subfamily_CG42327_pd Subfamily CG42327 300-368 4.7e-13 43.5 In-house 244-313 (319) alignment 
Range on Protein: 300-368
Range on HMM: 244-313/319.0
DDMRGPILVHCSDGGGRSGVYMSIDANLELAEEE-ECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEE
 . .||. |||||| ||.|. .. | ...  ||  .  ..   .  .|. |   | ..|||.||| .| |
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 427-675 7.3e-13 42.9 In-house 47-288 (305) alignment 
Range on Protein: 427-675
Range on HMM: 47-288/305.0
DNREKN--RDVLCVppDNFRPYLtsfQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQS-QQYPSFWPNKSK--
....||  .|| |.  || |  |   .|    .|| . .|   |.|. .| |. |...|  .|| . ...   |. .||.   .  ..   ... | |  
qeagknrykdvgcl..dnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

--MEKYGPVFSVHYVMSKSYTNIKQWEFKINKKIVslteMMAGVKAPTRTVQLFQLTCWPMgHKVPSSTNSLVYLMNmveiwRNKVDYGPVCVVSPDGRS
  .|. |   ||..  |...   |. . |... ..    .. |  . .| |. .    ||    ||.. .... |..     . ..  ||. |    |  
lefeekgqkisvkfessvtlkfrkdakakvtetvl....viegpgekarkvthyhwidwpd.rgvpaadlailelle.....karpskgpivvhcsagig

RAGVYCAANACIEQVIQHGEVDVF-QAVKTVRRHRPQLVENMTEYKYCYDLVLHYVL
|.|     .  ..|...   ..   . .. .|  | . ..  ..| . ....| |..
rtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 175-362 8.4e-13 42.4 In-house 98-280 (302) alignment 
Range on Protein: 175-362
Range on HMM: 98-280/302.0
GPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVR-EEQLANFH-IRTFRLYKM---NEKQEVTDERLILQFHYTE
 |  .|.. .| .. | |.. .| |..  .  .  | .|.  ... . ..|   .. |  ...|..|   ..|.||..   |||..   .. .  .... 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WYSHSCPFSNAllefrrrVRLvvgNIIKDEDDMRGPILVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFI
|  |  |             |   .|.|  .  .  .||||| | ||.|  ..|   ..|  ...  ..   .. .|| | | | . .|  ..
wpdhGapkeay.......tal...dilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
0048076 (Phosphotyrosine protein) phosphatases II 534-672 9.9e-13 43.5 In-house 11-141 (145) alignment 
Range on Protein: 534-672
Range on HMM: 11-141/145.0
VMSKSYTNIKQWEFKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRNKvDyGPVCVVSPDGRSRAGVYCAANACIEq
.   |... ...|.  . .|  .  ..   . ..|..  .. . || .| ||.... |  .....| .... . ||| |    |..|.|...||  ... 
lylgslptaldlellkdlgittvlnltselellerlgiqylylpwp.Dhgvpdllellleflefieealke.g.gpvlVHCsaGvgRtgtlvaaylmll.

viqHGeVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLH
   .| |....|.. ||..||. |.|.  ....|...|.
...lg.vsleealelvrsqrpgavpnpgqlrflyefele
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 401-599 2.1e-12 41.1 In-house 18-162 (392) alignment 
Range on Protein: 401-599
Range on HMM: 18-162/392.0
YQAEYDQICKQTPRFTIGDCAGGHRADNREKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVV
. | . .  .. |   | . . ... .| .|||    .| |. |  |   .  . .||.|. .....   . || .. |   .| .||..|.... ....
hsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttia

VLCQPPSQSqqypsfwpnkskmekygpvfsvhyvmsksytnikqwefkinkkivsltemmagVKAPTRTVQLFQLTCWPMgHKVPSSTNSLVYLMNMVE
.. .                                                              .|||  |..| ||  . ||  |.||. ... |.
mvtklkegd.....................................................kgddartvaqfhftewPd.kdvpkhtssllkfikevk
0048179 (Phosphotyrosine protein) phosphatases II 544-668 5.4e-12 41.2 In-house 21-139 (144) alignment 
Range on Protein: 544-668
Range on HMM: 21-139/144.0
QWEFKINKK---IVSLTEMmAGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVEIWRNkvDYGPVCVVSPDGRSRAGVYCAANACIeqviqHGEV
..|.  . .   ...|||       ..|..  .. . || .| ||.... |  .....| ...  . ||| |    |..|.|...||  ..     .  .
dlellkklgittvinltee.yepefleregiqylhlpwp.Dhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk.....klgl

DVFQAVKTVRRHRPQLVENMTEYKYCYD
....|.. ||..||. |.|.  ......
sleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 420-673 8.3e-12 39.3 In-house 29-268 (281) alignment 
Range on Protein: 420-673
Range on HMM: 29-268/281.0
CAGGHRADNREKNRDVLCVPPDNFRPYLTS-FQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQsqqypsfwpN
|.   .  | .||| .     |  |  |   .  .  |||| . ..      | ||.|. | | |  .|| ...... .|.|.|||             |
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqflet.........n

KSKMEKYGPVfSVHYVMSKSYTNIKQWEFKINKKIVSlTEMMAGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYLMNMVeiwRNKVdYGPVcVVSPDGR
. |  .| |    | ..      ..  .  .|| .|. | .    .  || .  .    ||   .|| |.. .. ..  .   | .    || .    | 
rekcaeyfpr.nahcclqfdklsvsyedstvnkslvt.trlnlsyegetrlithwlwkewp.dwqvpessevmlkilrki...rars.tppv.ihcsagv

SRAGVYCAANACIEQVIQHGEV-DVFQAVKTVRR-HRPQLVENMTEYKYCYDLVLHY
 |.|   | . ... .  |  . |. | |  .|   |   |. . .|   . ..| .
grsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 422-585 1.9e-11 38.0 In-house 90-237 (244) alignment 
Range on Protein: 422-585
Range on HMM: 90-237/244.0
GGHRADNREKNRDVLCVPPDNFRPYLTsfQGNAFTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQppsqSQQYPSFWPNKSK
     .|  |||.   .| |  |  |.  .|.    |||. ||    .  |||.|. |.  |  .|| .. ..    .|||       ..   .||.   
dafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs....veeedeywpdsep

MEKYGPVFSVHYVMSKSYTNIKQWEFKINKkivsltEMmagvKAPTRTVQLFQLTCWPMGHKVP
.| |    .|       . |||  ...|.       .|    .   ... .||.. ||     |
lewyeeditvtltdrdefknikasnleies......dm....neshqaltmfqisnwpsdgttp
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 401-594 4.5e-11 37.1 In-house 9-189 (297) alignment 
Range on Protein: 401-594
Range on HMM: 9-189/297.0
YQAEYDQICKQTPRftiGDCAGGHRADNREKNRDVLCVPPDNFRPYLTsfQGNAFTDYINSVFVD--GYTKPREYIVTEWPMKHTLGEFWSLVYDQECSA
 .||.| . ...     .. .  .|     |||    .  |. |  |   .. . .||||. .|      ..  ||... |.. |. .|| ||..|.  .
leaekdllldearg...esfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrv

VVVLC--QPPSQSQQYPsFWPNKSKMEKYGPVFSVHYVMSKSYtnikqwEFkiNKkiVSLTEMMAGVKAPTRTVQLFQLTCWPmGHKVPSSTNSLVYL
.|...  |   ... .| .||.  .  .  . . | .. | |       ||  ..  | |||.    .. .| |.  |   ||  | |||  . || .
ivmvaklqedGrdkcap.ywpsvvqerlkagdvvveflsstsd......ef..dr..viltelqliyrsesrvvrhvqflswp.dhGvpsdledlvrf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 166-256 6.4e-11 36.2 In-house 234-320 (440) alignment 
Range on Protein: 166-256
Range on HMM: 234-320/440.0
KPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDfakVMCHQYWPPNMEVhEQYGDIFINIVREEQLANFHIRTFRLYKMNEKQEV
| ||.| || |.. ||  .||.| . .||.|.|| .  |     |  ||| |      .| . .     |..   ..||. |   .| .|.
kknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrs.vtfgpftvghkgsenmnrvkvrtlelkykeevhei
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 453-677 1.5e-10 35.2 In-house 77-292 (305) alignment 
Range on Protein: 453-677
Range on HMM: 77-292/305.0
NAFTDYINSVFVDGYTKP-REYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQ-QYPSFWPNKsKMEKYgPVFSVHYVMSKSYTniKQWEFKIN
 . .||| . .|     | . .|... |. .|. ||| .| ..    .|.||.     . .   .||   . ||   . |   |   | .  |  |   .
pspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa.qgekl.elksgivvenvsgs..kpmerdae

KKIVSLTEMMAGVKapTRTVQLFQLTCWPMGHKVPSSTNSLVYLmNmvEIWRNKVdygPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVD-VFQAVKTV
 .|  |   ..| .  . .|. .| | ||     |    ||  |     |   ||   |. |    |  |.|   | .  .|.. .  ..  . . ||..
iqitllnltysgdq..kmsvrhlqwtewpdrgvppckltslell.s..airgskv...pivvhcsagigrtgtivaieyilekiaenkpcppmpelvkal

RRHRPQLVENMTEYKYCYDLVLHYVLHF
| .|   ..|  .| . . ..| |.|  
rdqrafsiqndvqylfihrvmlnyflek
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 107-199 5.3e-10 33.3 In-house 18-107 (332) alignment 
Range on Protein: 107-199
Range on HMM: 18-107/332.0
QTAAKVESNTCRHALkkNNLEKNQNPKCIPYDYNRVVLEKVGGlqDSDYVNASYVDSLLKPNAYIVTQGPVEE-TVQAYWRMVWQENISAIVML
.|.|    ||  . |  ||.. |. |.   .|..|| |    |    |. |||.||   | .|||..| |... |   .|||| . . | |...
htsamtypntydkfl..nnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf
subfamily_hpo-7_pd Subfamily hpo-7 168-325 5.7e-10 33.5 In-house 38-176 (263) alignment 
Range on Protein: 168-325
Range on HMM: 38-176/263.0
NAYIVtqgpVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWPPNMEVHEQYGDIFINIVREEQlaNFHIRTFRLYKMNE-KQEVTDerlILQFH
| |..    . .|........ | . . .|||.   . ... | .|.| . .   .. .. .   .  .  .  ..|  | .. . |... .   . .. 
nlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkktht...vkhys

YTEWYSHSCPfsnalLEFRRrVRlvvgNIIKDEDDMrGPILVHCSDGGGRSGVYMSIDA
|. |  .  |      ..|  ..    ||.|   .   .. |||| |.|||  .  .. 
ykgWiekndp.....elare.il....nilkvarns.kslvvhcstGiGrsaafsvaEl
subfamily_CG42327_pd Subfamily CG42327 429-523 8.9e-10 32.7 In-house 29-125 (319) alignment 
Range on Protein: 429-523
Range on HMM: 29-125/319.0
REKNRDVLCVPPDNFRPYLTSFQGNAFTDYINSVFVDGYTK-PREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQS-QQYPSFWPNKSKME
..|.| .  ||  . |. | .   .  . |... .| || . |  || .. ... .  .|| .|..|    .| |...  .  .. . ..| |  ..
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 424-676 1.6e-09 31.8 In-house 43-281 (303) alignment 
Range on Protein: 424-676
Range on HMM: 43-281/303.0
HRADNREKNR--DVLCVppDNFRPYLTSfqgnafTDYINSVFVDGYTKPReYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQ-PPSQSQQYPSFWPNKS
.  .| .|||  ||.|.  |  .  |.       . || . ...  .. .  |.|. |. ||  .|| .. .|    |..|      ..    | .|.. 
qfvknmdknrfvdvicl..dhskvklsd......ssyihasyleldsskk.ailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq

KMEKYGPVFsVHYVMSKSYTNIKQWEFkinkKIVSLTEmmaG-VKAptrTVQLFQLTCWPMGhKVPSS-TNSLV-YLMNMVEIWRNKVDYGPVCVVSPDG
 . |.   . .     |     . | .    |..|...   |  |.    ... .   || . ..||  .  .|  . ..  . |.  |  |   .|  |
dflkfeers.irvgefkrvelgdgwvl....kvlsvsn...gdyks...flhvhhykawphn.sipsdgspkfvkqiwqlqsvlrkysdstptvymslsg

RSRAGVYCAAN-ACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLH
  ||| ..  . | .    .   .|. . ...||  | . |.|.... . | |.  .|| 
cgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvld
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 308-374 2.9e-09 31.1 In-house 2-68 (69) alignment 
Range on Protein: 308-374
Range on HMM: 2-68/69.0
VHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGK
|||| | ||.| ...|  ..     |   ..|  .. .|. |  .| | ..| ||.|.| | .  ||
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklGk
subfamily_eak_pd Subfamily eak 423-556 3.6e-09 30.5 In-house 47-174 (332) alignment 
Range on Protein: 423-556
Range on HMM: 47-174/332.0
GHRADNREKNrDVLCVPPDNFRPYLTSFQGNAfTDYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPS-QSQQYPSFWPNKS-
. | .. ..|  |  || | .   ||| | |    |||.  ..     |.||.|  . .  .  || .|..|   |.| | .    . ...  ..|.|. 
tarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

KMEKYGpvfsVHYVMSKSYtnIKQWEFKINKKIVSL
.  |.|    .  |  |..  .|.  ..  . ..| 
eelkfG....ildverkef..vkrniletrllelsk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 307-374 3.9e-09 30.8 In-house 2-69 (69) alignment 
Range on Protein: 307-374
Range on HMM: 2-69/69.0
LVHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDTLEEHIICGK
.|||| | ||.| ...|  ..     |   ..|  .. .|. |  .| |  .| ||.|.| | .  ||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealklGk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 458-675 4.1e-09 30.6 In-house 69-277 (312) alignment 
Range on Protein: 458-675
Range on HMM: 69-277/312.0
YINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQSQQYPSFWpnKSKMEKYGPvFSVHYVMSKSYTNIKQWeFKINKKIVSlT
|| . ||   |||  ...|. |.. |   || |.    ......||    .. .  . .   | .  .   .  | | ... |.|.    | . ||    
yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcaky..isdivgfvd.ledhrvyteycteieig.gkskdkith.r

EMMAGVKAPTRTV--QLFQLTCWPmGHKVPSSTNSLVYLMNMVeiwrnKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQ
 .   |||  .    . .| . ||  | .| | ..   |.  |     | |  ||      |  |.|  .  .. |  . .    .| ..   .|. | .
vlkvvvkatgqesklnhyqwaswp.dhgmpdscdtalrllsav.....kkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrar

LVENMTEYKYCYDLVLHYVL
 |. . .| |.   ||... 
svrvfpqyvyalrcvlefly
subfamily_CG42327_pd Subfamily CG42327 596-673 1.3e-08 28.9 In-house 236-314 (319) alignment 
Range on Protein: 596-673
Range on HMM: 236-314/319.0
NMVEIWRNKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQH-GEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHY
|.     .. ..||. |   ||  |.|.  |..  |... .    ||. | |  ||| | . | ..  |.. |  .  |
nissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 121-175 2.2e-08 28.1 In-house 44-95 (95) alignment 
Range on Protein: 121-175
Range on HMM: 44-95/95.0
LKKNNLEKNQNPKCIPYDYNRVVLEKvggLQDSDYVNASYVDSLLKPNAYIVTQG
  . |. ||.  . .|||  ||||      .||||.|| .||   . |.|| .||
sseanipknrflnifpydatrvvltt...krdsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 455-675 2.3e-08 28.3 In-house 58-271 (285) alignment 
Range on Protein: 455-675
Range on HMM: 58-271/285.0
FTDYINSVFVDGYTKP-REYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQPPSQS-QQYPSFWPnkskmEKYGPVFSV-HYVMskSYTNIKqwEFKINK
  ||| . ..    |    || |. |.  || .|| ..|... . |..||       ..   ..|     || | |  . .| .  . |. |  |  |  
drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp.....eklgevvkfgkyei..tlteck..eeaiag

KIVSLTEMMAGVKAPT--RTVQLFQLTCWPMgHKVPSSTNSLVYLMNMVEIWRNKvdYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTV
 |.    ..    | .    ..  |.  ||  .  |  .  .. | . |.    |    |.||    |  |.  .   . .  ....  ...... |. .
tilnaltvintedasseplymnhvqvpwwpd.qlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyatirimenpniemldivrem

RRHRPQLVENMTEYKYCYDLVLHYVL
|  | | |..  .. . | ... |..
ramrfqavqshmqflflyvvlmeyfi
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 482-676 2.5e-08 28.4 In-house 78-261 (290) alignment 
Range on Protein: 482-676
Range on HMM: 78-261/290.0
HTLGEFWSLVYDQECSAVVVLCQPPSQSQQYPSFwpnksKMEKYGPVfSVHYVMSKSYTNIKQWEFKINKKIVSLTEMMAGVKAPTRTVQLFQLTCWPMg
 |. .|| .. . .   || ||.   .|..  .|       .|| |  ||   .     ..|  .   .. .   . ..   .    ||.  .|  | . 
StiekfwwmakqEkvkqvVmlcefeeksantslf.....aCakYvpe.svgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnk.

HKVPSSTNSLVYLMNMVEiwrnkVDYGPVCVVSPDGRSRAGVYCAANACIEQVI-QHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYVLH
 .|. .| .|. |...|.         || |   ||.||  .  | .     .. ..|.| . ...|..|..| ... . .|. .    .. .. .
lnvqedtktllsliqkvk.....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaie
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 135-241 4.8e-08 27.4 In-house 3-96 (130) alignment 
Range on Protein: 135-241
Range on HMM: 3-96/130.0
IPYDYNRVVlekvgglqDSDYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDfakvmCHQYWPPNmEVHE-QYGDIFINIVR
......|.         . .|.|||.|  | . . |. || |. .|   .|.|. .  .  .|.|    .       .|||   |  |    || . .  
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsvee.....edeywpds.ePlewyeediivtltd

EEQLANFH
 ..  | .
rdefknik
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 603-674 6.1e-08 25.6 In-house 238-309 (346) alignment 
Range on Protein: 603-674
Range on HMM: 238-309/346.0
NKVDYGPVCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKYCYDLVLHYV
..|    |||||  |  ||  .  |   |.|. .  | .... .|.... ||  || ...|   | .|. |.
kqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 457-556 1e-07 26.3 In-house 14-109 (130) alignment 
Range on Protein: 457-556
Range on HMM: 14-109/130.0
DYINSVFVDGYTKPREYIVTEWPMKHTLGEFWSLVYDQECSAVVVLCQppsqSQQYPSFWPNKSKMEKYGPVFSVHYVMSKSYTNIKQWEFKINKKIVSL
.|||  ||    . .||. |. |.  |  .|| .. ..    .|||       ..   .||.   .| |     |     . . |||  ...|.....  
tyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs....veeedeywpdsePlewyeediivtltdrdefknikasnleiesdlnes
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 299-367 1.4e-07 25.6 In-house 258-341 (350) alignment 
Range on Protein: 299-367
Range on HMM: 258-341/350.0
EDDMRGPILVHCSDGGGRSGVYMSIDANLE----LAEEEECFN-----------VFGYLKKLRQSRKGLVENVEQYKFIYDTLE
...   ||||||| | || |.....|  |.    | . .. ..           ..  ...||. |  .| |..|. |||..| 
dnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 115-163 2.7e-07 24.3 In-house 37-85 (440) alignment 
Range on Protein: 115-163
Range on HMM: 37-85/440.0
NTCRHALKKNNLEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNASYVDS
. .  |   ||  ||.  . . ||..||.||.| |. ||||.||||...
qpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 118-199 4.5e-07 23.7 In-house 30-116 (347) alignment 
Range on Protein: 118-199
Range on HMM: 30-116/347.0
RHALKKNNLEKNQNPKCIPYDYNRVVLE----KVGGLQDS-DYVNASYVDSLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVML
  .  ...|.||.  .    |  ||||     | .  .|.  |.|||..      . ||.|| |. .||. .|.||   ... .| .
tsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 300-366 4.9e-07 23.4 In-house 262-340 (349) alignment 
Range on Protein: 300-366
Range on HMM: 262-340/349.0
DDMRGPILVHCSDGGGRSGVYMSIDANLE-LAEEEECFN-----------VFGYLKKLRQSRKGLVENVEQYKFIYDTL
.|   ..||||| | ||.||.. .|  |. |   .. .|           ..  . .||. |  .|.|. |. .||..|
tdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 149-215 6.9e-07 22.9 In-house 86-154 (349) alignment 
Range on Protein: 149-215
Range on HMM: 86-154/349.0
GLQDSDYVNASYVD--SLLKPNAYIVTQGPVEETVQAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWP
. .  ||.|| |.    .   . || || |.  ||. .....  ...  .. |.. .. .   |..|| 
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 208-361 1e-06 22.5 In-house 148-293 (332) alignment 
Range on Protein: 208-361
Range on HMM: 148-293/332.0
VMCHQYWPPNmEVHEQYGDIFINivREEQLANFHIRTFRLYKMNEKQevtDERLILqFHYTEWYSHScPFSNALLEFRRRVRLVVGNIIKDEDDMRGPIL
 .|...|| . . ....  . |.    .. .. |..|| |   ..||   | . .| .|. ||   |  . . .|..|  ..|      |      |||.
kicrkfwpek.rskkdfpalsiq..asddhsethmktfnltvtekkq...dhqtvl.mhfyewadas.klpeymldmrasiklqyirsskktgvcigpim

VHCSDGGGRSGVYMSIDANLELAEEEECFNVFGYLKKLRQSRKGLVENVEQYKF
. |. |  .  .. .||  .    ||    .   .  ..  | | .  |  |  
lvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpyst
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 115-227 3.3e-06 20.1 In-house 18-105 (169) alignment 
Range on Protein: 115-227
Range on HMM: 18-105/169.0
NTCRHALKKNNlEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNAsyvdsllkpnayivtqgpveetvqaywRMVWQENISAIVMLTKTFDFAKVMCHQ--
|     |  |.  ||.    .   . || |..|     |||.||                           ||.|. | | ||.|  | |       .  
nnfmaeltcne.tknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpeked

-YWPPNMEVHEQYGDI
    | . . | | | 
yqlhpavilgewytds
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 477-665 5.6e-06 20.0 In-house 97-279 (302) alignment 
Range on Protein: 477-665
Range on HMM: 97-279/302.0
EWPMKHTLGEFWSLVYDQECSAVVVLCQPP-SQSQQYPSFWPNKSKMEKYGPVFSVHYVMSKsyTNIKQWEFKINKKIVSLTEMMAG-VKAPTRTVQLFQ
  | | ||  .|.|. . . . || ||.   .. ... ... .| . |     ..|. |  |  |.....  | . |. ..        |.  .||....
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvk..tdleeftdkksfklytveiknekkkkkvkktvdila

LTCWPmGHKVPSSTNSLVYLMNMVEIWRNKVdygpvCVVSPDGRSRAGVYCAANACIEQVIQHGEVDVFQAVKTVRRHRPQLVENMTEYKY
 ..||  |  |  ... . ...  | ....|      |    |  |.|   |    |.   ..   |. . |. ||. |   | . .   |
fsawp.dhGapkeaytaldilkfcesykknv.....lvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 115-210 5.8e-06 19.2 In-house 17-84 (169) alignment 
Range on Protein: 115-210
Range on HMM: 17-84/169.0
NTCRHALKKNNlEKNQNPKCIPYDYNRVVLEKVGGLQDSDYVNAsyvdsllkpnayivtqgpveetvqaywRMVWQENISAIVMLTKTFDFAKVMC
|     |  |.  ||.    .   . || |..|     |||.||                           ||.|. | | ||.|  | |      
nnfmaeltcne.tknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwp