Gene Ptp52F in Drosophila melanogaster

Synonym: CG18243, CT18044, DPTP52F, Dmel\CG18243, PTP52F, Dmel_CG18243, Ptp52F

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily Ptp52F
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP038_AA protein Get Run
DmelP038_AA_1083-1351 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1099-1351 1.4e-92 306.2 In-house 23-282 (564) alignment 
Range on Protein: 1099-1351
Range on HMM: 23-282/564.0
EKLAREFKEITVV-ALELSYSASELGCHKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQV
 |. .|.|.|.     . . .. .   .|||||.| .||..||.|      |||||||||||||....|.|||||||..|...|||||. ..|...|| .
lkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVml

TQFREGNTIKCHEYYPYN----VRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCS
|. .| .. |||.|.| .    . .||||....| |. |  ..... . |   . .| ...| .|||||||| . .|. ...||.| ..|   |||||||
tkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCS

AGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
|||||||||| .| ...|.|.| ...|...||.|| ||  ||||..|| |..   .| ..
aGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
0050432 (Phosphotyrosine protein) phosphatases II 1081-1354 2.5e-89 294.9 In-house 24-303 (308) alignment 
Range on Protein: 1081-1354
Range on HMM: 24-303/308.0
GNVIAKNFAIFYTEVAKPEKLAREFKEITVVALELSYSASELG--CHKNRYADIFPYDKNRVILdiDaEGSDYINASFIDGH--TRKKEYIATQGPKPES
 ..  .... .. .   . .| .||.|.. |   |.||...|    .|||| ||.|||..||.|  | |||||||||..||.   .....||||||.|..
lklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..d.egsdYInAsyvdgyssklprkfIatqgPlpnt

VMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVR-------GLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLI
| |||||. ..|||||| .|.. | . .||..|.| ..        ..|||..| |||. | ...|.... ..|   .| |.... |||||||..| .|.
vedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeill

MFVKKVKAEKRPsySPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKI
 |...|.   ..  .||||||||||||||||| |||....|. | ....||.||||| ||. |||| .|| ||| . .|..| |.
dflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0036941 (Phosphotyrosine protein) phosphatases II 1088-1355 8.2e-88 289.8 In-house 2-282 (297) alignment 
Range on Protein: 1088-1355
Range on HMM: 2-282/297.0
FAIFYTEVAKPEKLAREFKEITVVALELSYSASELGC--HKNRYADIFPYDKNRVILdiDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMIL
.......   . .| .||.|.. . |  |.|...| .  .|||| ||.|||..||.|  | |||||||||..||. .|...||||||.|..| |||||..
llkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvw

QYNVRVIVQVTQFREGNTIKCHEYYPYN------VRGLTVTIKSKEV--LELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKA
..||.||| .|.. | . .||..|.|..      . ..||| .| ||  |. | ...|.|.. ..| . .| |.....||||||||.| .|. |...|. 
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

--EKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLK---SESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIP
  .. || .|..|||||||||.||||..||..|.|.    | ...|.|.||||| ||. .||| .|| ||| . .||.|.| .
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0047943 (Phosphotyrosine protein) phosphatases II 1090-1350 3.8e-85 280.9 In-house 3-272 (273) alignment 
Range on Protein: 1090-1350
Range on HMM: 3-272/273.0
IFYTEVAKPEKLAREFKEITVVALELSYSASELG--CHKNRYADIFPYDKNRVILdiDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQY
.....   . .|..||.... .  .|.||...|    .|||| ||.|||..||.|  . .||||||||..||. .|...||||||.|..| |||||. ..
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NVRVIVQVTQFREGNTIKCHEYYPYNVRG-------LTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKR
|||||| .|.. | . .||. |.| .. .       .|||..| |. . |  ..|.... ..| . .|.|.....|||||||... .|. |...|.   .
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

P--SYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
   | .|.||||||||||||||| |||....|. | .....|.||.|| ||. |||| .|| ||| . .|..
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 1101-1354 7e-85 280.1 In-house 2-278 (284) alignment 
Range on Protein: 1101-1354
Range on HMM: 2-278/284.0
LAREFKEITVVAL----ELSYSASELGCHKNRYADIFPYDKNRVILDIDAEG---SDYINASFIDGH-----TRKKEYIATQGPKPESVMDFWRMILQYN
| .||.|.. .      .||... .   .|||| ||.|||..||.|.   ..   |||||||..||.      .||..||||||.|..| |||||....|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VRVIVQVTQFREGNTIKCHEYYPYN-----VRGLTVTIKSKEVLELYDRTELTVVHDK-YGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKR--
||||| .|.. | . .||. |.| .       ..|||..|.|| . | ...|.... .  |   .|.|.....|||||||..| .|. |...|.   .  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

PSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSES---KINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKI
|. .||||||||||||||||| |||....|. |.   .....|.||.|| ||. |||| .|| |.| . .|..|.|.
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 1099-1350 5.1e-84 277.4 In-house 23-286 (288) alignment 
Range on Protein: 1099-1350
Range on HMM: 23-286/288.0
EKLAREFKEITVVALEL--SYSASELGCHKNRYADIFPYDKNRVILDIDA--EGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQ
 .|..||.|.. .   |  |... .   .|||| ||.|||..||.|      |||||||||.|||. .|...||||||.|..| |||||. ..|||||| 
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvm

VTQFREGNTIKCHEYYP----YNVRGLTVTIKSKEVLELYDRTELTVVHD----KYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPI
.|.. | . .||. |.|    ...  .|||..| |||. |  ..|.|..     . | . .|.|.....|||||||..| .|. |...|.   ... .|.
ltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpv

VVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
||||||||||||||| |||....|. | .....|.||.|| ||. |||| .|| |.| . .|..
vVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 1114-1355 2e-83 275.6 In-house 34-281 (317) alignment 
Range on Protein: 1114-1355
Range on HMM: 34-281/317.0
ELSYSASELGCHKNRYADIFPYDKNRVILDIDAE--GSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYP
. |... .   .|||| ||.||| .||.|  . .  .|||||||..||. .|...||||||.|..| |||||. ...|.||| .|.. | . .||..|.|
tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwp

----YNVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIM
     .. ..|||..| |.|. .  ..|.|.... . . .| |.... |||||||..| .|. |...|..  ... .|..||||||||||||||...|..
lgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylml

QRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIP
..|. | .....|.||.|| ||...||| .|| ||| . .|..|.|..
eqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
DSPc_SM00195 1104-1350 9.5e-82 269.6 In-house 5-262 (263) alignment 
Range on Protein: 1104-1350
Range on HMM: 5-262/263.0
EFKEITVVAL--ELSYSASELGCHKNRYADIFPYDKNRVILDIDA--EGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFR
||...   .   | . .. .   .|||| .|.|||..||.|. .   ||||||||..|.|...||.|||||||.|. | |||||... .|..|| .|.. 
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EGNTIKCHEYYPYN------VRGLTVTIKSKEVLE-LYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSA
| . .||..|.| .      .  ..|.....|  .  . ...|.. ...   . || .| .|.|||||||....... ....|| .|. | .||||||||
engkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
||||||||. .|.|...|..|.|..|||.||.|| ||..||||..||.|.| .  |..
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1104-1350 9.5e-82 269.6 In-house 5-262 (263) alignment 
Range on Protein: 1104-1350
Range on HMM: 5-262/263.0
EFKEITVVAL--ELSYSASELGCHKNRYADIFPYDKNRVILDIDA--EGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFR
||...   .   | . .. .   .|||| .|.|||..||.|. .   ||||||||..|.|...||.|||||||.|. | |||||... .|..|| .|.. 
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EGNTIKCHEYYPYN------VRGLTVTIKSKEVLE-LYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSA
| . .||..|.| .      .  ..|.....|  .  . ...|.. ...   . || .| .|.|||||||....... ....|| .|. | .||||||||
engkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
||||||||. .|.|...|..|.|..|||.||.|| ||..||||..||.|.| .  |..
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0039614 (Phosphotyrosine protein) phosphatases II 1087-1354 3.4e-81 268.3 In-house 20-293 (297) alignment 
Range on Protein: 1087-1354
Range on HMM: 20-293/297.0
NFAIFYTEVAKPEKLAREFKEITVVALELSYSASELGCHKNRYADIFPYDKNRVILDIDA---EGSDYINASFIDGHTR-KKEYIATQGPKPESVMDFWR
.......   .. .| .||.|.  .  . |.....   .|||| ||.||| .||.|       ..|||||||..||. . ....|||||| ||.| ||||
dlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwr

MILQYNVRVIVQVTQFREGNTiKCHEYYPYNVR---GLTVTIKSKEVLELYDRTELTVVHdkYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEK
|. ...|.||| .|.. | .  ||..|.| ..    ..||| .. |.|. | ...|.|..  .|   .| |. . .|||||||... .|. |...|.   
mvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

R--PSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKI
.  |.  |..||||||||||||||...|....|..| .....|.||.|| ||...||| .|| ||| . .||.|.| 
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0045450 (Phosphotyrosine protein) phosphatases II 1080-1351 5.3e-81 268.0 In-house 8-305 (307) alignment 
Range on Protein: 1080-1351
Range on HMM: 8-305/307.0
FGNVIAKNFAIFYTEVAKPEKLAREFKEITVVAL----ELSYSASELGCHKNRYADIFPYDKNRVILDIDA---EGSDYINASFI--------DGHTRKK
| ..    ......    ...|..||...  |      | |.....   .|||| ||.||| .||.|       |.|||||||..        ||. .|.
fidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkr

EYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN-----VRGLTVTIKSKEVLELYDRTELTVVHD-KYGLKEKVIHYYFKKWPD
..||||||.||.| |||||. ...|.||| .|.. | . .||..|.| .      . .||| .|.|.|. | .. |.| .  . |   .|.|.....|||
kfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpd

HGVPEDPMHLIMFVKKVKA--EKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESK---INIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
||||... .|. |...|..  |. |. .|..||||||||||||||...|....|..| .   ....|.||.|| ||...||...|| ||| . .||..
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_PTPRB_pd Subfamily PTPRB 1084-1353 1.6e-79 262.0 In-house 8-288 (293) alignment 
Range on Protein: 1084-1353
Range on HMM: 8-288/293.0
IAKNFAIFYTEVAKP--EKLAREFKEITVVALELSYSASELGC--HKNRYADIFPYDKNRVIL--DIDAEGSDYINASFIDGHTRKKEYIATQGPKPESV
 ...|. .......    ... |..|.  |  . . .|.|| .   |||| .| |||..|| |    | .|||||||..|.|.. ..|.|||||| ||.|
klekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetv

MDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN-----VRGLTVTIKSKEVLELYDRTELTVVHdkYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFV
 |||||... ....|| .||  |.  .||.||.| .        ..||....|.|| .   ||.. .     ..|| .| |. ||||||||..  |. ||
ddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfv

KKVKAE--KRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHK
..|. .  |  | .||||||||||||||||| || ..|....|  ..|| .| .|| .|. .|||..|| |.. |  .|...|
rtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
0043336 (Phosphotyrosine protein) phosphatases II 1113-1350 4.2e-79 261.2 In-house 35-277 (278) alignment 
Range on Protein: 1113-1350
Range on HMM: 35-277/278.0
LELSYSASELGCHKNRYADIFPYDKNRVILDIDAEG--SDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYY
 . |.....   .|||| ||.||| .||.|. . .   |||||||..||. .....|||||| ||.| |||||. ...|..|| .|.. | . .||..|.
dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYw

P---YNVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIM
|   ... ..||| .. |.|. | .. |.|.. ..| . .| ||....||||||||.. .|. |.|.|.   ..| .|..||||||||||||||.|.|..
pggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialylll

QRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
..|..| .....|.||.|| ||...|||..|| ||| . .|..
eqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 1125-1347 1.9e-77 255.2 Pfam-A 3-234 (235) alignment 
Range on Protein: 1125-1347
Range on HMM: 3-234/235.0
HKNRYADIFPYDKNRVILDIDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYP------YNVRGLT
.|||| || ||||.|| |. . . ||||||....|...||..|||||| .... |||||..|..|.|||..|.  | .  ||..|.|      ..   ..
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

VTIK-S-KEVLELYDRTELTVVHDKYG-LKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESK
|..| . ||  . |  ..|.. ..|    |..| .. ...||||||||.| .|. ...||. .|... .|.||||||||||||||. ||.....|..|..
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee

INIFETVKKLRFQRMKMVQTQQQYTFLYACTY
......||.|| ||..|||. .|| |||..  
vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1125-1347 1.9e-77 255.2 In-house 3-234 (235) alignment 
Range on Protein: 1125-1347
Range on HMM: 3-234/235.0
HKNRYADIFPYDKNRVILDIDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYP------YNVRGLT
.|||| || ||||.|| |. . . ||||||....|...||..|||||| .... |||||..|..|.|||..|.  | .  ||..|.|      ..   ..
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

VTIK-S-KEVLELYDRTELTVVHDKYG-LKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESK
|..| . ||  . |  ..|.. ..|    |..| .. ...||||||||.| .|. ...||. .|... .|.||||||||||||||. ||.....|..|..
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee

INIFETVKKLRFQRMKMVQTQQQYTFLYACTY
......||.|| ||..|||. .|| |||..  
vdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1103-1351 4.4e-77 254.2 In-house 24-281 (318) alignment 
Range on Protein: 1103-1351
Range on HMM: 24-281/318.0
REFKEITVVALELS--YSASELGCHKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQF
.|..... .  . .   | ..   .|||||.| .||. || |.   . ||||||||..|||..|||.|||.|.| || . |||||. . | .||| .|| 
eeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqe

REGNTIKCHEYYPY----NVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEK-RPSYSPIVVHCSAG
.|   .|.| |.|     .   |.|..|..  |. |   |..| ...   . .|  | . .|||.||||....|. .|..|.. . .....|||||||||
eergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaG

VGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
|||||.|| .| ...|.| |. ...|.|||.|| ||  ||||..||.|.|    | ..
vGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1099-1351 5.4e-75 247.4 In-house 23-284 (319) alignment 
Range on Protein: 1099-1351
Range on HMM: 23-284/319.0
EKLAREFKEITVV-ALELSYSASELGCHKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQV
 .|..|||..    . ... .  |   .|||| .| .||. ||.|    . |||||||||||||. .....||||.|. . . |||||. .... ..| .
tllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvml

TQFREGNTIKCHEYYPYNV---R-GLTVTIKSKEVLELYDRTELTVVHDKYGL-KEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVK-AEKRPSYSPIVVH
|.  |   .|...|.|..       |.||....| || |   .|.. . .  .   .| |.....||||.|||. . |. ..|... . ....  |||||
tklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvh

CSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
|||||||||||| || ...|.| |. ...|.||..|| ||  |||...||.|.|    | |.
CsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
0045098 (Phosphotyrosine protein) phosphatases II 1110-1352 5.6e-75 247.6 In-house 20-274 (278) alignment 
Range on Protein: 1110-1352
Range on HMM: 20-274/278.0
VVALELSYSASELGCHKNRYADIFPYDKNRVIldidaegsDYINASFIDGHtrKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEY
    | ...  . . .|||| ||.||| .||.        ||||||.|||.  .|..||||||.|. | |||||. .....||| .|.. |.. .||..|
gipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

YP----YNVRGLTVTIKSKEVLELYDRTELTVVHD----KYGLKEKVIHYYFKKWPDHGVPEDP--MHLIMFVKKVKAEKR-------------PSYSPI
.|    ..  ..|||..| |||. |  . |.|..     ... . .| |.... |||||||..|  .... ... ...  .             .|  |.
wpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

VVHCSAGVGRTGTFIGLDLIMQRLksESKINIFETVKKLRFQRMK-MVQTQQQYTFLYACTYELVKH
.||||||||||||.....|....|  |......|.||.|| ||.  .||...|| ||| . .||...
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0042113 (Phosphotyrosine protein) phosphatases II 1120-1351 1.1e-73 242.9 In-house 6-244 (245) alignment 
Range on Protein: 1120-1351
Range on HMM: 6-244/245.0
SELGCHKNRYADIFPYDKNRVILDIDAEG--SDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYP----YN
 .   .|||| ||.||| .||.|  | .   |||||||..||. ... .|||||| ||.| |||||. ......|| .|.. | . .||..|.|    ..
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslt

VRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKR-PSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKS
. ..||| .| |.|. | ...|.|...... . .||||..  |||||||... .|. |.. |.   . .|  |..||||||||||||||...|....|..
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek

ESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
| .....|.||.|| ||...|||..|| ||| . .||.|
elgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1091-1350 1.8e-73 242.4 In-house 14-283 (305) alignment 
Range on Protein: 1091-1350
Range on HMM: 14-283/305.0
FYTEVAKPEKLAREFKEITVVALELSYSASELGCHKNRYADIFPYDKNRVILDIDAEG--SDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYN
. ..| . ..|  ..|...     .    .|   .|||...|...|..|.||  . .   |||||||..||. |||.||..||| .. | ||||.|... 
kearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveek

VRVIVQVTQFREGNTIKCHEYYPYNVRG------LTVTIKSKEVLELYDRTELTVVH-DKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRP
|..||..|. .||.  ||. |.| ...       ..|..||..  . |   .|..   |.   .  |..| . .|||||||. .  |. ..|.|. ... 
vstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

SYS-PIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
.   |..|||||||||||.|| .|. ..||| |  ...|| .|.|| .|||||||..||.||.    ||.
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_PTPRA_pd Subfamily PTPRA 1118-1348 4.8e-73 240.9 In-house 53-293 (330) alignment 
Range on Protein: 1118-1348
Range on HMM: 53-293/330.0
SASELGCHKNRYADIFPYDKNRVILDID--AEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN--
.. |   .|||. .|.||| .||||      | |||||||||||. .|...||.|||| |.| |||||| ...   || .|...| .  ||. |.| .  
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGl

--VRGLTVTIKSKEVLELYDRTELTVVHDKYGL----KEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIM
     ..|... ..||. |   .. | .   .     .  |  ..|. ||| ||| .|. .. ..||||. .. | .||||||||||||||||| || ..
vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavl

QRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYE
.|.|.| |...||.||.|| || .||||..||.|.|    |
ervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
0040439 (Phosphotyrosine protein) phosphatases II 1119-1352 1.4e-72 239.6 In-house 7-248 (249) alignment 
Range on Protein: 1119-1352
Range on HMM: 7-248/249.0
ASELGCHKNRYADIFPYDKNRVILDIDAE--GSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYP----Y
  .   .|||| ||.||| .||.| |  .  .|||||||.|||  .|...|||||| ||.| |||||. .....||| .|.. | . .||..|.|    .
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsl

NVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKA--EKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRL
.. ..||| .| ||.. | ...|.... ..| . .| |... .|||||||... .|. |...|.   |. |. .|..||||||||||||||...|....|
eygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleql

KSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKH
. | .....|.||.|| ||...||...|| ||| . .||...
ekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1103-1351 1.7e-72 238.9 In-house 25-280 (288) alignment 
Range on Protein: 1103-1351
Range on HMM: 25-280/288.0
REFKEITVVALELSYSASEL--GCHKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQF
.|.. .. .  . | .|..|    .|||| .| ||| .|| |.   . .|.||||||.|||. .||.||||||| ...| |||... ....  || .|..
eeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltel

REGNTIKCHEYYPYNVR-----GLTVTIKSKEVLElyDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAG
 ||.  ||.||.| . .      .|||..... ||  | .. ..  .| . . .. .| .. ||||||||. . |. ....||  .     ||.||||||
veggktkCeeYWPdadkpknyGsvtvtlveskele..dfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaG

VGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
|||||||| || .......| .|....||.||| ||. .|||..|| |.| .  .|..
vGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1100-1349 3.5e-71 234.9 In-house 28-289 (298) alignment 
Range on Protein: 1100-1349
Range on HMM: 28-289/298.0
KLAREFKEITVVALELSY-----SASELGCHKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVI
..| ||.... |  |.       . ..   .||||||| ..|. ||.|    . | ||||||||........ .||||.| .|.| |||||. .... .|
gyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigti

VQVTQFREGNTIKCHEYYPY----NVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSY-SPIV
| .|. .| ...|.|.|.|     .   .||...|||.   .  ..|.| . |   ...| .  | .|||.||||    .. ...||.| .. .  .|..
VmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvi

VHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYEL
|.|||||||.|||| .| ...|.| |... .|..|| || .|...|||..||.|.|  . | 
vqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_PTPRG_pd Subfamily PTPRG 1100-1352 2.7e-70 232.2 In-house 20-289 (563) alignment 
Range on Protein: 1100-1352
Range on HMM: 20-289/563.0
KLAREFKEI--TVVA--LELSYSASELGCHKNRYADIFPYDKNRVILDIDAE--GS-DYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVI
....||...  ....  |. . |  .   .|||| .| .||. || |   ..  .. |||||..|||. ..|..|||||| .. . |||||| . || .|
gfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaii

VQVTQFREGNTIKCHEYYPY----NVRGLTVTIKSKEVLELYDRTELTVVHDKYGLK------EKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPS
| .|.. | .  ||. |.|     ..  |.||....||| ||   .|.. . |   |       .|..| . ||||||||| ..  ..|||| .| ..  
vmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankae

YSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKH
  |||||||||||||||.| || .......|...|.|...|..| ||  .|||. ||.||.    |... 
aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1101-1351 1e-69 229.8 In-house 17-277 (281) alignment 
Range on Protein: 1101-1351
Range on HMM: 17-277/281.0
LAREFKEITVVALELSYSASE--LGCHKNRYADIFPYDKNRVIL--DIDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVT
...|..... . .. . .||.     .|||| .|. ||. || .  . ... .|||||.|..| . .||||||||| |.|...||.|.....|..|| ||
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvt

QFREGNTIKCHEYYPYNV-----RGLTVTIKSKEVLELYDRTELTVvHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKV-KAEKRPSYSPIVVHC
.  |.. .||| |.| .        .||. ...|  . | . .... . . | . .| .  ...|||||||.....|. | |.| |.... .  |.|.||
reieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihC

SAGVGRTGTFIGLDLIMQRLKSE-SKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
|||||||||.|.|| .......| ..... ..|..|| .|. ||||  ||.|.|    . ..
saGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
0037934 (Phosphotyrosine protein) phosphatases II 1116-1349 3.1e-69 228.5 In-house 3-241 (243) alignment 
Range on Protein: 1116-1349
Range on HMM: 3-241/243.0
SYSASELGCHKNRYADIFPYDKNRVILdidaEGSDYINASFIDGHtrkKEYIATQGPKPESVMD----FWRMILQYNVRVIVQVTQFREGNTIKCHEYY-
|.. .. . .|||| ||.||| .||.|    ||||||||..|..    . .|||||| ||.| |    ||||. .....||| .|.. | . .||..|. 
siallpenlsknrysdilpydhsrvkl....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp

-PYNVRGLTVTIKSKEVLELYDRTELTVVHDK-YGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAE--------KRPSYSPIVVHCSAGVGRTGTF
 ...  ..|||..| |.|. |  ..|.... . ..|.  ||||..  |||||||..| .|. |...|..         ...| .|..||||||||||||.
gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

IGLDLIMQRLksesKINIFETVKKLRFQRMK-MVQTQQQYTFLYACTYEL
| ..|....|    .....|.||.|| ||.  .|||..|| ||| . .||
iaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPN12_pd Subfamily PTPN12 1119-1354 4e-68 224.4 In-house 36-281 (290) alignment 
Range on Protein: 1119-1354
Range on HMM: 36-281/290.0
ASELGCHKNRYADIFPYDKNRVILDID--AEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNV--
 .|   .|||| ||.||||.|| |  .   ||||||||.|| | . |.||||.||| |. . |||||| ..||...| . .  | . .||. |.| ..  
ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee

----RGLTVTIKSKEVLE-LYDRTELTVVHDkyGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQR
      ..|| .... ..  .    |.| ..  . . ||  . ...|||||||. . .|. ....|.  .. . .|.||||||||||||| | .|.. . 
elefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrel

LKSESK---INIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKI
||.|     ...|. | .|| ||  .|||..||...| .  |||....
lkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkel
subfamily_Ptp69D_pd Subfamily Ptp69D 1099-1347 1.4e-67 223.0 In-house 22-283 (307) alignment 
Range on Protein: 1099-1347
Range on HMM: 22-283/307.0
EKLAREFKEIT--VVALELSYSASELGCHKNRYADIFPYDKNRVILD--IDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQ
. ||.|....    . .. . |. .    |||| || ..||.||.|   .  | ||||||||| |.  ||..|| |.|  . . |||||| . .| .|| 
fglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

VTQFREGNTIKCHEYYP----YNVRGLTVTIKSKEVLELYDRTELTVVHDK-----YGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSP
...  | |  ||. |.|     .   . |.. |.|  . | . || | . |        . ||. | .. |.|  ||| .  |. ....|.  .. . ||
lsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsP

IVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTY
|||||||||||.|.|. ||...|.|| | |..||||||.|| ||  .||  .||.|||    
ivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyrall
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1124-1348 5.1e-67 220.7 In-house 10-240 (250) alignment 
Range on Protein: 1124-1348
Range on HMM: 10-240/250.0
CHKNRYADIFPYDKNRVILDIDA--EGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIkCHEYYP----YNVRGL
 .||||||| ..|. ||.|  .   . ||||||||..|.. .| .|||||| .... |||||.|.... .|| .|...| .   .|.|.|     .  ..
keknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdv

TVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRP-SYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKI
||...|||.   |  ..| . . |   .  | .. |  ||| ||||     . ..|||.|...    .|..|.|||||||.|.|| .| ...||| | ..
tvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvv

NIFETVKKLRFQRMKMVQTQQQYTFLYACTYE
..|. .|.|| .|...|....|| |.|    .
dvfkvikvlrkdrphavesleqyvfvyeiilk
subfamily_PTPN9_pd Subfamily PTPN9 1101-1350 1.1e-65 216.6 In-house 18-290 (297) alignment 
Range on Protein: 1101-1350
Range on HMM: 18-290/297.0
LAREFKEITVVALE--LSYSASELGCHKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVT
| .|..||   . |  . .| . .  .||||.|.  ||. || |    . | ||||||.|.||. .|| .|||||| .. | |||||. . .|.||| .|
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmtt

QFREGNTIKCHEYYP------YNVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAE------------
.. |   .|| .|.|       .   |.|.  . |. | |  . |.. . | . . ||.|. |  |||.|||.. . |. ...||. .            
rvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdew

-KRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
  .||  |||||||||.||||||| ||. ..||.........||||.|| ||  ..||..||.| | .  |  
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN6_pd Subfamily PTPN6 1124-1352 4.2e-65 214.7 In-house 55-299 (306) alignment 
Range on Protein: 1124-1352
Range on HMM: 55-299/306.0
CHKNRYADIFPYDKNRVIL-DIDAEGSDYINASFIDGH--TRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRG----
 .||||  |.|.|..|||| . .  |||||||..|...  . .|.||||||  .. | |||||..| | |||| .|.  | .  ||  |.| . .     
keknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyG

-LTVTIKSKEVLELYDRTELTVVH-DKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSY----SPIVVHCSAGVGRTGTFIGLDLIMQRL
 ..||  |.. |. |.  ||.| . .| . . .|..| ||.|||||||.|| ... |...|..... .      |||||||||.||||||| .|.... .
kisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkli

KS---ESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKH
..   . .|.| ..||..| ||  .|||.||| |.|    . ...
ekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1110-1349 7e-65 214.4 In-house 48-292 (319) alignment 
Range on Protein: 1110-1349
Range on HMM: 48-292/319.0
VVALELSYSASELGCHKNRYADIFPYDKNRVILD--IDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTqfregnTIKCH
|   . ...  .    |||. .|...|||.| |.  |  |.||||||||..|. ||. |||.|||..... |||||| .||.  || .|        || 
vnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcs

EYYPYNVRG----LTVTIKSKEVLELYDRTELTVVH-DKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVK--AEKRPSYSPIVVHCSAGVGRTGTF
.|.| ..        | ..| |  . |   .. . .  |   . |.  ..|. |||.|||. |. |...||||.   .|     .|||||||||||||..
qywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy

IGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYE--L
| || ...|.| |........|. || || ..||   || |.|.   |  |
ivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1122-1350 2.6e-64 212.0 In-house 43-277 (315) alignment 
Range on Protein: 1122-1350
Range on HMM: 43-277/315.0
LGCHKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPY-NVRGLT
   .|||| .|.|.|..||.|..  |   |||||||.| .    | |||.|||.. || |||||.||..|  || ||. .||. |||  |.|  .     
infkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsve

VTIKSKEVLELY---DRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESK
    . |.|.|    | .   .|  |   ...|  . |..|||.||...   |. ..|.|||....   ...||||||||||| .| .| .....| .. 
fGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrs

INIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
...|..||.|| .|...|||...|.|.|    | .
vdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1116-1349 5.3e-64 211.4 In-house 18-256 (284) alignment 
Range on Protein: 1116-1349
Range on HMM: 18-256/284.0
SYSASELGCHKNRYADIFPYDKNRVILD--IDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTqfregnTIKCHEYYPYN
...  .    |||. .|...|||.| |.  |  |.||||||||| |. ||. |||||||..... |||||| .||.  || .|        || .|.| .
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk

VRG----LTVTIKSKEVLELYDRTELTVVH-DKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVK--AEKRPSYSPIVVHCSAGVGRTGTFIGLDLI
.        | ..| |  | |   .. . .  |   . |.  ..|. |||.|||. |..|...||||.   .|    ..|||||||||||||..| || .
ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvl

MQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYE--L
..|.| |........|..|| || ..||   || |.|.   |  |
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1118-1349 5.6e-64 211.1 In-house 38-275 (515) alignment 
Range on Protein: 1118-1349
Range on HMM: 38-275/515.0
SASELGCHKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPY---
.  |.  .|||| .|.|||..||.|..  |.  |||.|||.| .    | |||.|||.. || ||||..||.||  |. ||. .||. ||| .|.|    
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

-NVR--GLTVTIKSKEVLELYDRTELTVVHDKYglKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQR
  |.   . | . | |      . .|||....      |  . |..|||.|||..   |. ..|.|||..     |...|||||||||| .| .| .. .
dsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvah

LKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYEL
 |    ...|..|...| .|...||||.||.|.|    | 
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1099-1351 6.4e-64 210.7 In-house 5-269 (274) alignment 
Range on Protein: 1099-1351
Range on HMM: 5-269/274.0
EKLAREFKEITVVAlELSYSASELGCHKNRYADIFPYDKNRVILD---IDAEGSDYINASFIDGHTR-KKEYIATQGPKPESVMDFWRMILQYNVRVIVQ
..| .|| |. .   .          .|||| .|.| .. ||.|     ..| |.|||| .| |  . .| |.||||| |. |.|||||| | .|.||| 
kdlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

VTQFREGNTIKCHEYYPYNVRG------LTVTIKSKE--VLELYDRTELTVVHDKYglKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEK---RPSY
.|...| |  ||..|.| .           | || ..    . |  ..|.. . .   . .|.||.. .|||| .|.|. .|. .|..|. ..       
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenakl

SPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
.|.|||||||.|||| ||. .. ...|. |........| .|| .|  ||||..|| ...   .. .|
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN13_pd Subfamily PTPN13 1104-1351 7.1e-64 210.7 In-house 16-270 (273) alignment 
Range on Protein: 1104-1351
Range on HMM: 16-270/273.0
EFKEITVVA--LELSYSASELGCHKNRYADIFPYDKNRVILDidAEGSdYINASFIDGHTRKK--EYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFR
||||.  .   .. . . ..   .|||| ...|||. ||.|.  .||. |||||.|  .  |.  ||||.||| ||.| |||.|. . ...||. ||. .
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg..degg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlek

EGNTIKCHEYYPYNVR------G-LTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRpSYSPIVVHCSA
|.. .||| |.| . .      . |.|.    . |. .   .|.| . . |  ..| |  | ||||||||  ...|. ||..|.  .. . .||||||||
ekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsa

GVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
|.||.||.| .| ... .. . .... |.|.||| ||  .|||..|| | |  . |..|
GiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPRK_pd Subfamily PTPRK 1125-1348 3e-62 205.2 In-house 45-275 (314) alignment 
Range on Protein: 1125-1348
Range on HMM: 45-275/314.0
HKNRYADIFPYDKNRVILD-IDAE-GSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVR---GLTV
.|||. || .||. ||.|  || .  ||||||..||...| ...|.||||..| | ||||.....|   || .|.. |   .|| .|.| . .    . |
eknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikv

TIKSKEVLELYDRTELTVVH--DKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKIN
.. . |.|. .    ..| .   ..  . .| .. | .||||.||     |. .|..||. . ..  .|||||||| ||||||| .| ... .. |. ..
elvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvd

IFETVKKLRFQRMKMVQTQQQYTFLYACTYE
.|..||.|| ... ||.|..||.|.|    |
vfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1124-1348 6.7e-62 204.2 In-house 50-277 (315) alignment 
Range on Protein: 1124-1348
Range on HMM: 50-277/315.0
CHKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN---VRGLT
 .|||| .| .||| || | .    ..|||.||.||||...|. |||.|||...|| ||||.. ....  || .|.  ||.  |. .|.| .      .|
kqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkit

VTIKSKEVLELYDRTELTVVHDKYgLKeKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINI
|| ||.|| . |    |.|| ..  .. .|. . .  ||| |||.  . |. ....||  .  | ..|||||||||||||||| || ...... |  |..
vtrkseevnteytvrtlsvvfgdn.ir.evvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidv

FETVKKLRFQRMKMVQTQQQYTFLYACTYE
.. ....| .|.||||. .|| |.|    |
ynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_PTPN3_pd Subfamily PTPN3 1123-1350 1.2e-60 199.9 In-house 41-275 (280) alignment 
Range on Protein: 1123-1350
Range on HMM: 41-275/280.0
GCHKNRYADIFPYDKNRVILDIDAEgsDYINASFID----GHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN-----
  .|||| || |||. ||.|.      |||||....    ...  . ||||||| .... |||.|. . ....|| .|.  |   .|||.|.| .     
nlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetedele

VRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSE
  ...|......  . |   ||.. . .   . |...  .  |||||||.|. ... ||..|.. .. . .|.|||||||.|||| .| |.. .. . ..
ygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaa

SKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
 .... . |...| ||. .|||..||.|.  .. .. 
epvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1123-1348 1.8e-60 199.4 In-house 47-276 (287) alignment 
Range on Protein: 1123-1348
Range on HMM: 47-276/287.0
GCHKNRYADIFPYDKNRVILDidAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNV----RGLT
  .|||...| ..|..||.|    |  |||||.||||.  ||..|....|  . . .||..| . || .|| ..| .| .. .|..|.| .        .
nkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyn

VTIKSKEVLELYDRTELTVVHDK-YGLKEKVIHYYFKKWPDHG-VPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKI
... ..|| . |   .| | ...  | |..|  | . .|...| |.|    |... ...|...... ..||||||..|||...|.  .  ... | |  |
iellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGvi

NIFETVKKLRFQRMKMVQTQQQYTFLYACTYE
..|. .|. | |....||| .||.|..    |
Dvfqvlksqriqkpgsvqtveqykfindivle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1123-1347 1e-59 196.8 In-house 46-280 (290) alignment 
Range on Protein: 1123-1347
Range on HMM: 46-280/290.0
GCHKNRYADIFPYDKNRVILDIDAEGSD----YINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN----V
  ..||.|.| .|| ||..|   ..  |    ||||..|.|.  ||.||||||| .. ..|||..| | .| .|| .|.  | .. ||. |.| .    .
nkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkay

RGLTVTIKSKEVLELYDRTELTVVHDKY-GLKEKVIHYYFKKWPDHG-VPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKS
   .... . |.|. | ...| | ...  | |..|..| .. |...| |..    |... . .| ....   .||||||..|||...|. ..  ... |.
gefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkckt

ESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTY
|  |..|. .|..| |....|||.||| ...    
egvidvfqvlksqRiqkpgsvqtvqqyqgifqivl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1125-1351 1.5e-59 196.2 In-house 22-265 (270) alignment 
Range on Protein: 1125-1351
Range on HMM: 22-265/270.0
HKNRYADIFPYDKNRVILDID--AEGSDYINASFIDG-HTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRG-----
. |||||| |  . ||.|.     . . |||| .. | . .||.|||..||.| .. .|||||.. .|. || .|.. | .. ||  |.| ..       
klnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkle

---LTVTIKSKEVLELYDRTELTVVhdKYGLKEKVIHYYFKKWPDHGVPEDPM------HLIMFVKKVKA-EKRPSY-SPIVVHCSAGVGRTGTFIGLDL
   ..|.  |.|  | | .|.|..   . | .....|.....|||||||...       .|.  ...|.. ||. .  .|..||||||||||||.| || 
dgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDi

IMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
... |....|... . ...|| .||..||. .||.|||.   | ..
avrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1123-1349 2.6e-59 195.8 In-house 51-283 (297) alignment 
Range on Protein: 1123-1349
Range on HMM: 51-283/297.0
GCHKNRYADIFPYDKNRVILDIDAEG--SDYINASFIDGHTRkkEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTiKCHEYYPYNV----RG
  .|.||..| |||..||.| |  .   |||.||||. |     ..|.|| |....| |||.|.|...| .|| ...  |..  ||  |.. .       
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGd

LTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPE--DPMHLIMFVKKVKAEKRPSYS-PIVVHCSAGVGRTGTFIGLDLIMQRLKSE
..|...| .  | . . ||.| ..|   .  |  | | .|||. |..  .   |. ... |. .     . |..|||.||||||| .. .| .. . | |
vsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakre

SKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYEL
 ...||..||||| .|...|||..||.|.|    | 
kevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_PTPN23_pd Subfamily PTPN23 1112-1352 2.7e-58 192.1 In-house 32-282 (288) alignment 
Range on Protein: 1112-1352
Range on HMM: 32-282/288.0
ALELSYSASELGCHKNRYADIFPYDKNRVILDidAEGSDYINASFIDGHTRK-KEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYY
| . | ....|  .|||. ||.|||.||| |.   .  |||||||. . .    ..||||.|..... |||.|. .  ..||| ...  | .  |...|.
arkrsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYw

PYNV------RGLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKA----EKRPSYSPIVVHCSAGVGRTGTF
| .         |.||.||.. .| . . .|.. . .   ...| |  ...||..|||. | .|. |...|..    ..|.|  |.||||||||||||.|
PedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf

IGLDLIMQRLKSESK-INIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKH
  .  ... |. .   ..| . |..|| ||  |||...|. |.|    | ...
alvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_PTPN14_pd Subfamily PTPN14 1100-1350 6.2e-54 178.0 In-house 24-296 (300) alignment 
Range on Protein: 1100-1350
Range on HMM: 24-296/300.0
KLAREFKEITVVALELSYSASEL--GCHKNRYADIFPYDKNRVILDIDAE-GSDYINASFIDG--HTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQ
|.  |. .|.   ..  .|...|    .|||. |. ||..||| |    |  ..||||| |     .....||..||| .  | |||.|. . .|..||.
kvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivm

VTQFREGNTIKCHEYYPYN--------VRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRP-----
.|. .|.   |...|.| .             || | .|  . .  | |.. |   . . .|.|  .. |||||||||. . . ....|.. .|      
lteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsev

----SYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
    |  |..|||||||||||  |  ||... |. . .|.| .....|| ||| .|||  ||.|.|    . .
eskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1102-1348 2.7e-52 172.5 In-house 23-234 (392) alignment 
Range on Protein: 1102-1348
Range on HMM: 23-234/392.0
AREFKEITVVALEL-SYSASELGCHKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQF
. ||...    .   . .  |   .|||| .|.|||..||.|..  |   |||.|||.|..   .| |||.|||.. |. |||||..| ||  |. ||..
feefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtkl

REGNtikcheyypynvrgltvtikskevlelydrteltvvhdKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKrPSYS-PIVVHCSAGVGRT
.||.                                      |   .  |  ..| .|||..||.    |. |.|.|||.   .|. |...|||||||||
kegd......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf.Gqythpliihcsagvgrt

GTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYE
|  | .| .. . |    ...|. | ..| .|  ||||..||.|.|..  |
gvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
0041856 (Phosphotyrosine protein) phosphatases II 1125-1355 2.8e-52 172.3 In-house 3-176 (182) alignment 
Range on Protein: 1125-1355
Range on HMM: 3-176/182.0
HKNRYADIFPYDKNRvildidaeGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTqfregntikCHEYYPynvrgltvtiksk
.|||| ||.||| .|        ..|||||....|  . ...|||||| ...| ||.||. ......|| .|         .. |.|             
dknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

evlelydrteltvvhdkYGLKEKVIHYYFKKWPDHGVPEdPMHLIMFVKKVKAekrpSYSPIVVHCSAGVGRTGTFIGLDLIMQRlksesKINIFETVKK
                   |.  .|.|..  |||||||. . .|. |...|..    .  |..||||||||||||.....|....     .....|.|| 
.................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavkl

LRFQRMKMVQTQQQYTFLYACTYELVKHKIP
.| .|..||.| .|| ||. . .||...|. 
vrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1125-1349 1.9e-51 170.1 In-house 50-287 (325) alignment 
Range on Protein: 1125-1349
Range on HMM: 50-287/325.0
HKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVqVTQFREGNTIKCHEYYPYN------VRG
 |||. .. ..||.||.|    |.  |||||||..  . .|. ..|.| |..... |.||..|...  |.| |.   ...  .|  |.| .        |
aknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvv.vlneldlgkdrcavywpkemgksktfGg

LTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKR------PSYSPIVVHCSAGVGRTGTFIGLDLIMQRL
| | ... | .  |    | |   | |    |  . .. |.| ||.. |  || ... ||| .        . .||.|||||||||||.|| |  .....
levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakv

KSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYEL
  ||...||. ||||| .| .||.|  ||...| .  | 
ieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_PTPN1_pd Subfamily PTPN1 1116-1349 4.3e-51 168.3 In-house 23-270 (290) alignment 
Range on Protein: 1116-1349
Range on HMM: 23-270/290.0
SYSASELG--CHKNRYADIFPYDKNRVILDIDAEgsDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN
. ....|     .||| |. |||. |..|. .    ||||||... .  |..|| |||| |. |  ||.|. . . . .| . .. | ..|||..|.| .
ptreaklpenrnlnryrdvspydhsrikleradn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqg

VR---------GLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAE--KRPSYSPIVVHCSAGVGRTGTFIG
 .          |.|.. |.|. . | .  | .   |     ...|... .||| |||| |  .. |. ||.      . . | |.|||||.||.|||. 
eeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

LDLIMQRLKSESK---INIFETVKKLRFQRMKMVQTQQQYTFLYACTYEL
.| .. ... . .   ..| ... .|| .|. ..||..|  | |    | 
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1100-1346 2e-50 166.3 In-house 10-262 (283) alignment 
Range on Protein: 1100-1346
Range on HMM: 10-262/283.0
KLAREFKEITVVALELSYSASELGCHKNRYADIFPYDKNRVILDidAEGSDYINASFID---GHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVT
     .|...|  |.   ....   .|||. .| |.|..|| |.  .|  |||||.||     . ..|.||..|.|  . |.|||.|. . ..  || .|
lfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelk..sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

QFREGNTIKCHEYYPYN----VRGLTVTIKSKEVLELYDRTELTVVHD---KYGLKekVIHYYFKKWPDHGvPEDPMHLIMFVKKVKAEKRP-SYSPIVV
...|.. |||  |.| .       .|||..     . . . ||.. ..   |  |   . || .  | . | .. ..  .. . ||.. ..    .||||
klqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll..lahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivv

HCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACT
|||.|.|||..||..   .. ...|| ...|..|| .| ||| .|||..|| ...   
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0036282 (Phosphotyrosine protein) phosphatases II 1148-1343 4.3e-50 165.1 In-house 1-163 (174) alignment 
Range on Protein: 1148-1343
Range on HMM: 1-163/174.0
GSDYINASFIDGHTRKKEYIATQGPKPesvmdFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYnvrgltvtikskevlelydrteltvvhDKYGLKEK
||||||||..|.. . ...||.||| .     ||.|. .......|.... .| .  ||. |.|                            ... |.. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...........................lredlerl

VIHYYFKKWPDHGVPEDPMhLIMFVKKVKAEKRP-SYSPIVVHCSAGVGRTGTFIGLDLIMQRLKsESKINIFETVKKLRFQRMKMVQTQQQYTFLY
.|.|..  |||||||.... |. ||| |.      .  |..||||||||||||.....|....|. || ......|..||.||..||||..|| |||
giqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1126-1345 1.2e-47 157.2 In-house 6-234 (237) alignment 
Range on Protein: 1126-1345
Range on HMM: 6-234/237.0
KNRYADIFPYDKNRVILDIDAEGSDYINASFIDGH-TRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN-----VRGLTV
||||..|  ||..||.|     |||||||....|     |.|||.|||   |  |||.|. | .  ||| .| . ||| .|||.|.|          |||
knrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltv

TIKSKEVLELYDRTELTVVHdKYGLKE-KVIH-YYFKKWPDHGVPEDPMHLIMFVKKVKAEKR--PSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESK
..| || .  |    |.... .. ||| ..|| | |  |||.|||.    |. | |..  . .  .  .| ..|||||||||| |. .| .... | .  
slkkkeefsdytvrslllsk.rltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkv

INIFETVKKLRFQRMKMVQTQQQYTFLYAC
..|.. |. .  .|  ..||..|| |..  
vdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_PTPRN_pd Subfamily PTPRN 1098-1352 1.8e-47 156.5 In-house 28-294 (297) alignment 
Range on Protein: 1098-1352
Range on HMM: 28-294/297.0
PEKLAREFKEITVVALELSYS---ASELGCHKNRYADIFPYDKNRVILDID--AEGSDYINASFI-DGHTRKKEYIATQGPKPESVMDFWRMILQYNVRV
...|..|.. ..    | | .    .|   .|||.....|||..|| |. .  || |||||||.| |   |.  ||||||| ...| |||.|. .  | |
kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

IVQVTQFREGNTIKCHEYYPYNVRGLTVTIKSKEVLELYDRtELTVVHDKY------GLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSP
||..|. .| .. .|..|.| .   .    . . | |     .  .|   |           |  ..|  ||..|||  .  |. | .||    |   .|
ivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwc.ddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscp

IVVHCSAGVGRTGTFIGLDLIMQRLK-SESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKH
||||||.|.||||..| .||...||.    .|.|  |...|| || ..|.|..|. | ...  | |..
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevna
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1125-1345 3.4e-47 155.6 In-house 9-235 (239) alignment 
Range on Protein: 1125-1345
Range on HMM: 9-235/239.0
HKNRYADIFPYDKNRVILDID--AEGSDYINASFI-DGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNV---RGLT
 |||||.|  ||..||.|.       |||||||.. |     | ||||||    |  |||||. |    ||| .| . ||   |||.|.| .      | 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

VTIKSKEVLELYdrTELTVVHDKYGLKE--KVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKI
||..  ||.  |     |.|  . |  |   | .|.|  |||.|||.    .. . .|.  .  |   | |.||||||||||.|. .| .... | .  .
vtlrktevfady..iirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktv

NIFETVKKLRFQRMKMVQTQQQYTFLYAC
.||. || .| .| .|||| .|| |.. .
difnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1125-1345 4.4e-47 155.3 In-house 10-236 (239) alignment 
Range on Protein: 1125-1345
Range on HMM: 10-236/239.0
HKNRYADIFPYDKNRVILDID--AEGSDYINASFI-DGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNV---RGLT
 |||||.|  ||..||.|.       |||||||.. |     | ||||||    |  |||||. |    ||| .| . ||   |||.|.| .      | 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

VTIKSKEVLELYdrTELTVVHDKYGLKE--KVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKI
||..  ||.  |     |.|  . |  |   | .|.|  |||.|||.    .. . .|.  .  |   | |.||||||||||.|. .| .... | .  .
vtlrktevfady..iirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktv

NIFETVKKLRFQRMKMVQTQQQYTFLYAC
.||. || .| .| .|||| .|| |.. .
difnyvkairedrphmvqtseqyvfihla
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1124-1345 5.1e-47 155.0 In-house 39-272 (287) alignment 
Range on Protein: 1124-1345
Range on HMM: 39-272/287.0
CHKNRYADIFPYDKNRVILDIDAE-GSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYP-----YNVRGL
 .||||||..|.|..||.|  ..| ||||||| .. ..|.....||.||| . .| ||||..|. .. ... .|.  |    ||..|.|       | | 
vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGy

TVTIKSKEVLEL-YDRTELTVVHdKYGLKEKVIHY-YFKKWPDHGVPEDPMHLIMFVKKVK----AE-KRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRL
.|.. .....|  |    | ...   . . .|..   . .|||....   . || || .||    .. .     |.|||...|.||.|... .  ...||
svvlldydikePeygvralrlid.letrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrl

KSESKINIFETVKKLRFQRMKMVQTQQQYTFLYAC
..  ....  .| .|| .|  .||.  |. .||  
edlGrvdvaavvirlreyraalvqavvqlrllyea
0043147 (Phosphotyrosine protein) phosphatases II 1147-1345 6e-47 154.9 In-house 3-156 (172) alignment 
Range on Protein: 1147-1345
Range on HMM: 3-156/172.0
EGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFregntikcheyypynvrgltvtikskevlelydrteltvVHDKYGLKE
|||||||||..|..   ...|||||| .. . |||||. ......|| .|..                                       ..|...|..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.......................................lydpeller

KVIHYYFKKWPDHGVPeDPMHLIMFVKKVKA-EKRPSYSPIVVHCSAGVGRTGTFIGLDLIMqrlkseSKINIFETVKKLRFQRMKMVQTQQQYTFLYAC
 .|.|..  ||||||| .. .|. |.. ..    . .  |..||||||||||||.. ..|..       .....|.|. .| .|...||...|| ||| .
lgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrflyyf
0051429 (Phosphotyrosine protein) phosphatases II 1148-1350 4.1e-46 153.1 In-house 3-225 (272) alignment 
Range on Protein: 1148-1350
Range on HMM: 3-225/272.0
GSDYINASFIDGHTR---KKEYIATQGPKPESVMDFWRMiLQYNVRVIVQVTQFREGNTIKCHEYYP----------------YNVRGLTVTIKSKEVLE
 |.||||....| .|   .. .....|| | .. ||||.  ......|| ...  | .  ||. | |                ...  |.||. |.|.|.
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

LYDRTELTVVHD-KYGLKEKVIHYYFKKWPDHGVPEDPmhLIMFVKKVKAekrpsYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKIN--------IF
 |  .||....  ..|   .| |...  |||||||...  |. ... . .       |..||||||..||||.. |.|.....  |  ..        ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

ETVKKLRFQRMKMVQTQQQYTFLYACTYELV
|.|..|| ||...|||..|| ||| .  ||.
eaveelraqrpgavqteeqylflyeallell
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1110-1351 1.1e-45 150.9 In-house 31-280 (439) alignment 
Range on Protein: 1110-1351
Range on HMM: 31-280/439.0
VVALE----LSYSASELGCHKNRYADIFPYDKNRVIL-DI-DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNT
 .  .     |  | |    |||| |. ..|  ||.| .|     | |||| .|.|.  .| |||||||| |.. ||||.... ..  ||..|.. |   
stspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk

ikcheYYPYNVRGL--TVTIKSKEVLELYD--RTELTVVHDK-YGLKEK-VIHYYFKKWPDHGVPEDPMHLIMFVKKVK-AEKRPSYSPIVVHCSAGVGR
     |.| .       ....    .|| .     . |. ..  . ||. |.....  |||. || .  |.. |.. .. |. .  | |.||||||||||
.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGr

TGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
||| | ||. ...||.| |..|   || || || .|||.  || |.| .  | ..
tGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv
0049772 (Phosphotyrosine protein) phosphatases II 1120-1352 2e-45 151.2 In-house 43-282 (314) alignment 
Range on Protein: 1120-1352
Range on HMM: 43-282/314.0
SELGCHKNRYADIFPYDkNRVILD-IDAEGSDYINASFIDGHtrkKEYIATQGPKPESVMDF----------WRMIL--QYNVRVIVQ------------
 .|. .|||| ||.|.| |||||.  . .||||||||..||.   . .||||||... | ||          |||.|  ..|||.||             
lflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------VTQFREGNtikcHEYYPYNVRGLTvtikskevlelydrtelTVVHDKYGLKEKVIHYYFKKWPDHGVPeDPMHLIMFVKKVKAEkrPSYSP
          ... ...     |. . ..  |                  ....|.  ... .|.|.   .||...| .. ..  |.. ...   .  .|
LdaAlgKtpllildgng....neptaadlellk.................eelydpelferlgikylripvpDgsap.lledfdeflefieea..dkggp

IVVHCSAGVGRTGTFIGLDLIMQRLksesKINIFETVKKLRFQRM-----KMVQTQQQYTFLYACTYELVKH
..|||.||.||||||. ....| .|    .... |... .| .|.      ......|| | . . .|..| 
vlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1099-1345 2.8e-45 149.6 In-house 16-272 (307) alignment 
Range on Protein: 1099-1345
Range on HMM: 16-272/307.0
EKLAREFKEITVVALE-LSYSASELGCHKNRYADIFPYDKNRVILDIDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQ
..|  ||....  . | ..  | .   .|||| |.   ||.|... .|   |||| | ..   .. | .|..|||. ... .|| |..| .|  .. . .
qalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

FREGNTIKCHEYYP--------YNVRGLTVTIKSKEVLELYD---RTELTVVHDKYGLKEKVI-HYYFKKWPDHGVPEDPMHLIMFVKKVKAEKrpsySP
  |   |||..|.|        .  .. |....   . .|       ..| .. ... | . | |. ...|||.|||.  .  | ... |. ..     |
vielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydt....np

IVVHCSAGVGRTGTFIGLDLIMQRL-KSESKINIFETVKKLRFQRMKMVQTQQQYTFLYAC
.||||||||||.|| ... |..... . .   .. . |..|| ||   .||. || .|.  
vvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1117-1347 3.4e-45 149.0 In-house 34-290 (301) alignment 
Range on Protein: 1117-1347
Range on HMM: 34-290/301.0
YSASELGCHKNRYADIFPYDKNRVILDID----AEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPY
 . ||   . ||. .| .||.||.||           .|||||.||| ..||..||.|||  . ..||||.|.|. .  || ||. .||   ||..|.| 
vglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpn

------NVRGLTVTIKSKEVLE----------LYDRTELTVVHDKYGLK-----EKVIHYYFKKWPDHGV-PEDPMHLIMFVKKVKAEKRPSYSPIVVHC
      ..  .|||.... |.           ..| .. . .. |.  |      .|. .   .||..|| .|  . |    . ........ .|.||||
seaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHC

SAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTY
|..|.|.|... ... .   |.|  ...|. .| .| .....|.| .|||..|    
SdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_CG7180_pd Subfamily CG7180 1125-1350 1.4e-44 146.9 In-house 44-290 (296) alignment 
Range on Protein: 1125-1350
Range on HMM: 44-290/296.0
HKNRYADIFPYDKNRVILD-ID-AEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTiKCHEYYPYN----VRGLT
 |||. .. |||.|||.|. .|  | ||||||...|....||||| |..|| |.| .|||.. . ..  .| .|.  . .  ....|.| .     . . 
eknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeif

VTIKSKEVLELYDRTELTVVHD---------KYGLKEKV-IHYYFKKWPD-HGVPEDPMHLIMFVKKVKA-----EKRPSYSPIVVHCSAGVGRTGTFIG
| | ... .      .. ...          .   ....  .. ...|.  . ||     || ....|.      ...| ..|.||..| |..|.| ...
veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvyla

LDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
.|  .. .. | ....|| ||.|| .| ..|.. ..| ..|    | |
idanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1104-1346 7.5e-44 144.7 In-house 14-255 (267) alignment 
Range on Protein: 1104-1346
Range on HMM: 14-255/267.0
EFKEITVVALELSYSASELGCHKNRYADIFPYDKNRVILDIDAEgsDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNT
. |.|.     .| | .|    .||. |  |||..||||    |  .|||||...|. .|. .|.||.|   .. ||. .| ...| ||| .|.  ..| 
likkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkee..eyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdni

IKCHEYY---PYNVRGLTVTIKSKEVLELYDRTELTVvHDKYGLKEKVIHYYFKKWPDhGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTF
 . .        . . |||    ..  . |.   | . . |     .|  ||.|||    . . |    .|    | .      |.||.||.||||.|||
rlfwPPkmgqakkyqdltvehslekeendyqiitlel.kfknesahnvtlyyykkwni.ntnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtf

IGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACT
. .|  ..|.| |.  .||. ..|.| ||. .|.|...| ...   
lvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1087-1344 1.3e-43 143.7 In-house 13-277 (290) alignment 
Range on Protein: 1087-1344
Range on HMM: 13-277/290.0
NFAIFYTEVAK--PEKLAREFKEITVV-----ALELSYSASELGCHKNRYADIFPYDKNRVILDiDAEGSDYINASFIDGHtrKKEYIATQGPKPESVMD
 |  | ..|.|  ...||.|. |  .       || .    .   .|||| |.   || ||||. |    ||. | ...|   |  .| |||.  ..|.|
afekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk.dGydGdyvhanyvkGl..kamfiltqGalkdtvid

FWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVR------GLTVTIKSKEV-LELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFV
.|||.|| .| .|| . .  |    ||..||| .         .||.   ..   .   .  |.| . . | . |. |.  | |||. |.   . |.  .
iwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtl

KKVKAekrpSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYA
. ..        |.|||||||.||||||. ..  .| |    .... ..|. ||  |.. || . ||  |  
rilrk....asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalve
0049260 (Phosphotyrosine protein) phosphatases II 1156-1344 6.6e-43 141.3 In-house 1-144 (152) alignment 
Range on Protein: 1156-1344
Range on HMM: 1-144/152.0
FIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYpynvrgltvtikskevlelydrteltvvhdkyglkekviHYYFKK
||||. ...|.|||||| |... |||||. ......|| .|.. | . .||..|.                                       .|..  
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.......................................qylhlp

WPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMqrlkseSKINIFETVKKLRFQRMKMVQTQQQYTFLYA
|||||||.....|..... ..  .. .  |..||||||||||||.. ..|..       .....|.|. .| .|...|....|. ||| 
wpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 1140-1351 4e-42 139.3 In-house 3-174 (176) alignment 
Range on Protein: 1140-1351
Range on HMM: 3-174/176.0
VILDIDAEGSDYINASFIDGHtrkkEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYnVRGLTVtikskevlelydrteltvvh
. |... ...|||||..|.|.     .|||||| |....||..|.........| .|. .| . .||. |.|. ...| .                    
lrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi....................

dkyglkekviHYYFKKWPDHGVPEDpMHLIMFVKKVKAEKRPSySPIVVHCSAGVGRTGTFIGLDLIMQrlksESKINIFETVKKLRFQRM-KMVQTQQQ
          .|..  |||||||..  .|. ... ..   .    |..||||||.|||||.. ..|..     |  ....|.....| ||. ..|||..|
..........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQ

YTFLYACTYELVK
| ||| . ..| |
yrflyefellllk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1124-1350 2.3e-39 129.9 In-house 49-287 (305) alignment 
Range on Protein: 1124-1350
Range on HMM: 49-287/305.0
CHKNRYADIFPYDKNRVILdIDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN--------VR
 .|||| |.   |.||| |   .   .|| | ..   |  | .| || |  ..  ||| | || .|  |  . .. |  . ||.||.. .         .
agknrykdvgcldnnrvkl.egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeek

G--LTVTIKSKEVLELYDRTELTV------VHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVkaekRPSYSPIVVHCSAGVGRTGTFIGLDLIM
|  ..| ..| . |.. . .. .|      .    . ..|| ||..  ||| |||   . .. ...|     |||  |||||||||.||||. . |. |.
gqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvmleyil

QRLKSESKINIFET-VKKLRFQRMKMVQTQQQYTFLYACTYELV
..| .  .|.  .  ..|.| || . .||..|| |..    . .
dqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1124-1344 9.8e-39 127.7 In-house 38-263 (281) alignment 
Range on Protein: 1124-1344
Range on HMM: 38-263/281.0
CHKNRYADIFPYDKNRVILDI---DAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRGL---
 .||||..|   |  || | .   . . .||| | .|     |. || ||||| |.  |||||| | |   || . || | |  || ||.| | .     
nkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqf

---TVTIKSKEVLELYDRTELTVVHDkyGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKrpsySPIVVHCSAGVGRTGTFIGLDLIMQRLKSES
   .|. .   | .    | | . ..  |    . |. .|.|||  |||    ..  ..|..|      .| |.||||||||.||.. ... .| ..|  
dklsvsyedstvnkslvttrlnlsye..getrlithwlwkewpdwqvpessevmlkilrkirars....tppvihcsagvgrsgtlmaveialqsihshf

KI-NIFETVKKLRF-QRMKMVQTQQQYTFLYA
 . .| . | .||   |   ||| ||| ... 
tlpdikqivshlrvtgraasvqtlqqymliwk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1115-1352 1.5e-37 124.0 In-house 42-284 (301) alignment 
Range on Protein: 1115-1352
Range on HMM: 42-284/301.0
LSYSASELGCHKNRYADIfPYDKNRVILDIDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNV
.  | . |  .|.||  . | . .  .  |.      | | .|. . . . .|||||| ...  ||| |. ||.|  || ..|..| .. ||.||.| ..
itesyaylpkdkhryptv.PckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

R------GLTVTIKSKEVL--ELYDRTELTVVHDKYGLKEK-VIHYYFKKWPDHGVPEDPMHLIMFVKKVKAekrpSYSPIVVHCSAGVGRTGTFIGLDL
.        ...||.||..  .   . .| |.     .. . |.|| ...|.|.|||.  ..|  ... ||     |  |||||||||.||. .||| . 
sekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigtey

IMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTF-LYACTYELVKH
. ...... .|.. |..|.|| .| . |||..|  .    . | |.| 
lareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlike
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1115-1348 1.9e-37 123.8 In-house 27-268 (285) alignment 
Range on Protein: 1115-1348
Range on HMM: 27-268/285.0
LSYSASELGCHKNRYADIFPYDKNRVILDidAEGSDYINASFIDGHTR-KKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN
 .|.| |     |||||.   .. ||.|       ||| ||..    . .  ||.|||| ||.. |||.|| | ..  .. .  . ||   ||  ||| .
ctytayeanpdlnryadvrcieetrvvlk..nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypek

VR--------GLTVTIKSKEVLELYDRTELTVVHDKYGLKEKV--IHYYFKKWPDHGVPEDPMHLIMFVKKVKAeKRPSYSPIVVHCSAGVGRTGTFIGL
.          .|.|   .| .       |||.  .    | .   |     |||.  |||   .| . | ||    |   ||.|||||||||| ||.|.
lgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgi

DLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYE
|    |.  . .|.... |...|  |.. ||.. |. |||    |
dyatirimenpniemldivremramrfqavqshmqflflyvvlme
PTPc_DSPc_SM00012 1248-1346 6e-37 121.4 In-house 2-103 (105) alignment 
Range on Protein: 1248-1346
Range on HMM: 2-103/105.0
VIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSY--SPIVVHCSAGVGRTGTFIGLDLIMQRLKSE-SKINIFETVKKLRFQRMKMVQTQQQYTFLYA
| ||....||||||||.. ... ....|| .|. |.  .|.||||||||||||||. ||...|.|..| ....||..||.|| ||..||||..|| |||.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CT
. 
al
0044763 (Phosphotyrosine protein) phosphatases II 1135-1350 2.8e-36 120.2 In-house 2-171 (178) alignment 
Range on Protein: 1135-1350
Range on HMM: 2-171/178.0
YDKNRVILDI--DAEGSDYINASFIDGHtrkkEYIATQGPkpesvMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRgltvtikskevlelydr
.| .||.|.   . |.|||||||.|...     |.....|      |..... ......|| .|.  |.. .||..|.| .                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

teltvvhdkyglkekvIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRlksesKINIFETVKKLRFQRMkM
                |.|..  .||||||. . |.  ||. ...   .. .|..|||||||||.||.. ..|....     .....| .. .| .|. .
................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.i

VQTQQQYTFLYACTYELV
|... |. .|| .  .| 
vpnpgqlrqLyefelrll
0051082 (Phosphotyrosine protein) phosphatases II 1148-1347 1.6e-35 117.3 In-house 2-150 (151) alignment 
Range on Protein: 1148-1347
Range on HMM: 2-150/151.0
GSDYINASFIDGHtrkkeYIATQGPKPesvmDFWRMILQYNVRVIVQVTQFREGNtiKCHEYYPYNVrgltvtikskevlelydrteltvvhdkyglkEK
 |||||.|...|.     .....|| .    ||.... ......|| ...  | .  .|.||.| .                                 .
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...............................ie

VIHYYFKKWPDHGVPEDPMHLIMFVKKVKAekrPSYSPIVVHCSAGVGRTGTFIGLDLIMQRlkseskINIFETVKKLRFQRMKMVQTQQQYTFLYACTY
|.|...  |||.|.|. .  .. |.... .   ..  |..||||||.|||||...|.|....      ....|... .| .|. .||. ||. |.. . .
vlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlfall
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1108-1357 2.5e-35 116.6 In-house 41-298 (305) alignment 
Range on Protein: 1108-1357
Range on HMM: 41-298/305.0
ITVVALELSYSaSELGCHKNRYADIFPYDKNRVILDIDAeGSDYINASFIDGH-TRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKC
.| ||..   | ...   ||||.|.   |.. | ||  .  |||| | ..      .| .|..|||  ... .|| |..| .|  || . .  |   .||
mtqvafnanqs.adiaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkc

HEYYPYnVRGLTVTIKSKEVLELY------DR---TELTVVHDKY--GLKEKVIHYYFKKWPDHGVPedPMHLIMFvkKVKAEKRPSYSPIVVHCSAGVG
 .|.|   .|  ...||  |.|        .|    ..|...  |  . |  | |  . .||| |||  | .|  .  .. .  | |  |||||||||.|
aqywpa.aqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvp..pckltsl..ellsairgskvpivvhcsagig

RTGTFIGLDLIMQRLKSESKI-NIFETVKKLRFQRMKMVQTQQQYTFLYAC--TYELVKHKIPRA
|||| . .. |....  . .   . | || || ||   .|.. || |..     | | |.|   |
rtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekya
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1123-1351 2.8e-35 116.8 In-house 43-273 (288) alignment 
Range on Protein: 1123-1351
Range on HMM: 43-273/288.0
GCHKNRYADIFPYDKNRVILDIDAegSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVrGLTV---
 . ..|| ...  |  || |. |.    ||.|  .  .  |.  | .| |    .  .|.|.|. .|. || .... |    |  ||.| .. | ..   
nptrdryenlprcditrvklsddp..dfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl.Gekarig

---TIKSKEVLELYDRTELTVVHDKYGLKEKV--IHYYFKKWPDHGVPEDPMHLIMFVKKVkaekRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSES
   |.  |.  ..    ...... .   .|||   . ....|.|.||||. .  . ... .    .    |||||.|||||||||.|   .... |... 
rlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrldd

KINIFETVKKLRFQRMKMVQTQQQYTFLYACTYE-LVK
 . | . ..||| .|.| .||..|| ... | .| |. 
flgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_ptpA1_pd Subfamily ptpA1 1109-1310 2.9e-33 110.2 In-house 33-256 (418) alignment 
Range on Protein: 1109-1310
Range on HMM: 33-256/418.0
TVVALELSYSASELGCHKNRYADIFPYDKNRVILD--IDAEGSDYINASFIDGHTrKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKC
.|   | |    .    ||||..|.| .. || |    | |||||||| .|||    |..|.|||| |... |||||. .  .|.|| ...  |   |||
svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikc

HEYYPYNVRGLTVTIK--SKEVLELYDRTELTVVHDK-------------YGLKEKVIHYYFKKWPDHGVPEDP--MH-LIMFVKKVKAEKRPS---YSP
  |.| .. |  ..|    .||.  |    . |..|               |    . .| .. |||| .|.    .. |.  . . . .  ||     |
drywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvp

IVVHCSAGVGRTGTFIGLDLIMQRL
|.|||||||||||||    ..|..|
iivhcsagvgrtgtfctavimmkkl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1088-1344 1.2e-31 104.4 In-house 16-284 (310) alignment 
Range on Protein: 1088-1344
Range on HMM: 16-284/310.0
FAIFYTEVAKPEKLAREFKEITVV-ALELSYSASELGCHKNRYADIFPYDKNRVILDIDAE-GSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMIL
  |. ||    | |..... .       |.| | .   |||||.|.   |. || | ||     ||| | ..     .. .| .|||   ...||||||.
nfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmif

QYNVRVIVQVTQFREGNTIKCHEYYPYN-VRGLTVTIK------SKEVLELYDRtELTVVHDKYGLKEK--------VIHYYFKKWPDHGVPEDPMHLIm
|     |. . .  |    ||  |.|   |      |.      | | .|. .   .| | |.  . |.        |    . .||| |||..  | . 
qeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnl.avtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv.

fVKKVKAEKRpsYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYA
  ... |. |  . | |||||||..|... . |.| ...|.   |... | . .|. .|.. .||. ||...  
.pqrllaqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1095-1353 2.2e-30 100.4 In-house 15-279 (312) alignment 
Range on Protein: 1095-1353
Range on HMM: 15-279/312.0
VAKPEKLAREFKEITVVALELSYSASELGCHKNRYADIFPYDKNRVILDIDAegSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQ
.. |..|..|.| .  .  .   .|       ||| .|  .|. |  |  |     || | |.   |. . ...||||  ...  ||.. |      |. 
mstpqqltkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagde..nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiil

VTQFREGNTIKCHEYYPYNVR-----GLTV--------TIKSKEVLELYDRtELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRp
.. | |  . || .|    |         |         |  |    .  |  | ||    | . |. || .  |||||.|.       ..  || .|. 
lcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithr.vlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.

sysPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHK
   |.. |||||||||||.. .. ..  |.   | |. ..   || .| . |..  || .   |  |..  |
...pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
0048076 (Phosphotyrosine protein) phosphatases II 1222-1349 2.5e-29 97.2 In-house 21-142 (145) alignment 
Range on Protein: 1222-1349
Range on HMM: 21-142/145.0
KSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSySPIVVHCSAGVGRTGTFIGLDLIMQrlkseSKINIFET
. ..  .|  .| |.. .....|....|.|..  |||||||... .|. |.. ...  .    |..||||||||||||.....|...      .....|.
dlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleea

VKKLRFQRMKMVQTQQQYTFLYACTYEL
....| ||...|....|. ||| . .||
lelvrsqrpgavpnpgqlrflyefelel
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1118-1274 3.3e-29 96.7 In-house 26-192 (297) alignment 
Range on Protein: 1118-1274
Range on HMM: 26-192/297.0
SASE--LGCHKNRYADIFPYDKNRVILDIDAEGSDYINASFIDG--HTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYN
|..      .|||| ||. .|..|| |     ..||||| ..       .  || .|||  ..| |||... . .||||| |....|.   ||  |.|  
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

VRGL------TVTIKSKEVLElYDR---TELTVVHDkyGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKK
| .        |   |.   | .||   |||....     . .| |  |  ||||||| |   |  |  .
vqerlkagdvvveflsstsde.fdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaq
0048179 (Phosphotyrosine protein) phosphatases II 1226-1345 2.8e-27 90.6 In-house 48-140 (144) alignment 
Range on Protein: 1226-1345
Range on HMM: 48-140/144.0
VlelydrteltvvhdkyglkekVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSySPIVVHCSAGVGRTGTFIGLDLIMqrlksESKINIFETVKKL
                      .|.|..  |||||||... .|. |.. ...  ...  |..||||||||||||.. ..|..     . .....|... .
e.....................giqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalv

RFQRMKMVQTQQQYTFLYAC
| .|. .|....|. ||. .
rsrrpgavpnpgqlrfLley
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1121-1357 5.4e-26 85.7 In-house 49-292 (302) alignment 
Range on Protein: 1121-1357
Range on HMM: 49-292/302.0
ELGCHKNRYADIFPYDKNRVILDidAEGSDYINASFIDGHTRKKEYIATQGPKPESV---MDFWRMILQYNVRVIVQVTQFREGNTiKCHEYYP-----Y
    .||.  |.  .|.|.|.|.  ||  .|.||| ..    ... | .| || .|.    .||||. | ..  .| . .  | ..   .|..|     |
kknlkknqsedvpildsnlvkle..aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy

-NVRGLTVTIKSkeVLELYDRT---ELTVVHDkyGLKEKVI--HYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLI
 .   . | ..   | .  . .    . |. .  |  . |.   | .. |... ||.   .||  ..|| |.| .. ...|.    |.|| |.|. | . 
keygkmfvNnrk..VekaeeektryviEvlPe..gcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

MQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIPRA
...|..... || |.||..| || ..|.. .||..|| ..  ..|.|. . 
veklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkp
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1157-1354 1.4e-25 84.3 In-house 83-292 (302) alignment 
Range on Protein: 1157-1354
Range on HMM: 83-292/302.0
IDGHTRKKEYI-ATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRGLT----VTIKSKEV---L-ELYDRTELTV-------VHD
.||  .|..       || ...  .| .| |||| ..||...| |..  || |||  .|.|       |.|...|   | |. |. ....        . 
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

KYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRpsysPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYT
|  .|  |   .|  ||||| |... . .  .|  .. |.     ..||||||||||||.. .   .|  . .   .. . |. .|  |   ||..|| .
kkkvkktvdilafsawpdhGapkeaytaldilkfcesykk....nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli

FLYACTYELVKHKI
.|  |    . .|.
ylllcvtkglmeka
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1149-1345 7.8e-25 82.6 In-house 46-254 (290) alignment 
Range on Protein: 1149-1345
Range on HMM: 46-254/290.0
SDYINASFIDgHTRKKEYIATQGPKPES-------VMDFWRMILQYNVRVIVQVTQFREGNTI----KCHEYYPYNVR------GLTVTIKSKEVLELYD
.||| |...       . |.|| |. .        . .|| |. | .|. .|.. .| | ..      | .|.| .|       ||||  ||||  .  .
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

RTELTVVHDKyGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKrpsySPIVVHCSAGVGRTGTFIGLDLIMQRLK-SESKINIFETVKKLRFQRM
. ||.| .|. . . .| |. .| | .  |.||.  |.  ..||||.|    .|..|||  |. |  ..  ..| .| .  ....... . .|.|| || 
tRelvvkfdd.eeeftvtHsllkgWnklnvqedtktllsliqkvkask....tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqra

KMVQTQQQYTFLYAC
..........|  | 
laitsalelafvdag
subfamily_CG42327_pd Subfamily CG42327 1099-1277 9.1e-23 75.4 In-house 5-192 (319) alignment 
Range on Protein: 1099-1277
Range on HMM: 5-192/319.0
EKLAREFKEITvvALELSYSASELGC-HKNRYADIFPYDKNRVILDI--DAEGSDYINASFIDGHTR-KKEYIATQGPKPESVMDFWRMILQYNVRVIVQ
|..| ||...    |  .  .   ..  |.|.... |  . ||.|.   | . . |..||.. |.   .  |||.| .  .|  ||||.. . . |||||
edvaeefrdlP..qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivq

VTQFREGNTIKCHEYYPYNVRG--------LTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFkKWPDHGVPEDPMHLIMFVKKVKA
.|.  |    .| ||.| .  .        . ||.| .|| . |  . | . . .  .  .. ||.. ||.. .|| ..  ||  . .|..
ltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1125-1224 4.1e-22 73.4 In-house 49-165 (350) alignment 
Range on Protein: 1125-1224
Range on HMM: 49-165/350.0
HKNRYADIFPYDKNRVILD----------IDAEGSDYINASFIDGH----TRKKE--YIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHE
 |||| .|.||...||.|              ...|||||...         . .  |||||.| |. | ||...||. .|.||. .|.  | |  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YYP-YNVRGLTVTIKSK
|..  .. . || ..||
YWqegsydditvklask
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1124-1350 4.9e-22 72.9 In-house 48-279 (303) alignment 
Range on Protein: 1124-1350
Range on HMM: 48-279/303.0
CHKNRYADIFPYDKNRVILdidaEGSDYINASFIDGHTRKKEyIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRGLTVTIKS
 .|||..|.   |. .| |      | || ||... ...||  | || | . .  |||.||.. .|.... .    | ...  .  .| |   |    .|
mdknrfvdvicldhskvkl....sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeers

K-----EVLELYDRTELTVVHDKYGLKEKVIH-YYFKKWPDHGVPED-PMHLIMFVKKVKAE--KRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSE-
        .|| |   | |.    |     .| ...|.||   .| |   ...  . ....   |    .| |    .|.||.|||  ..     |.|| 
irvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseq

SKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
. ...   ....|  |.. ||   |....|.   | |
asldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1162-1354 8e-20 66.0 In-house 33-222 (255) alignment 
Range on Protein: 1162-1354
Range on HMM: 33-222/255.0
RKKEYIAtqgpkpeSVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVR------GLTVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKK
||. |.        .|  |...| | .  |.| .. | | .  ||..|.| .         ..||        .    |.|    .    ..| || .| 
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykG

WPDHGVPEDPMHLIMFVKKVKAekrpSySPIVVHCSAGVGRTGTFIGLDLIMQ------RLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYEL
|...  ||..  .   .| |.     |  ..|||||.|.||. .|.  .|. |      .  .  ...  . ...|| .| . ..|  | .|    . .|
WieknaPelareilnilkvvrd....s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

VkhkI
|    
v...f
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1248-1347 8.7e-20 65.7 In-house 217-341 (350) alignment 
Range on Protein: 1248-1347
Range on HMM: 217-341/350.0
VIHYYFKKWPDHGVPEDPMHLIMFVK-------KVKAE---KRPSYSPIVVHCSAGVGRTGTFIGLDLIMQ------RLKSES---------KINIFETV
| . ..|.|.| ..  .|  ..  ..       .  ||   .    |||.||||||||||||.. || ...       |. ||         .  |. .|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

KKLRFQRMKMVQTQQQYTFLYACTY
..|| ||..|||. .|. |.| .  
nelrkqrismvqnldqfifiYeall
subfamily_CG42327_pd Subfamily CG42327 1277-1351 4.3e-18 60.0 In-house 241-316 (319) alignment 
Range on Protein: 1277-1351
Range on HMM: 241-316/319.0
AEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSE-SKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK
. .| |. |.||||| ||||||. |  |. ...|.     ..| ..|  .| .| . |.|..|| |.|   .|  |
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1248-1348 4.6e-18 59.8 In-house 91-192 (440) alignment 
Range on Protein: 1248-1348
Range on HMM: 91-192/440.0
VIHYYFKKWPDHGVPEDPMHLIMFVKKVK-AEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACT
. .|... |||.|||.    .. ... |. .... . .|..||||||.||||  | .| |..  |   .|.||  .. .| .| .|||| .||.|.. . 
lkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheav

YE
 |
le
subfamily_egg_pd Subfamily egg 1110-1347 5e-18 59.8 In-house 27-267 (307) alignment 
Range on Protein: 1110-1347
Range on HMM: 27-267/307.0
VVALELSYSASELGCHKNRYADIFPYDKNRVILDIDAE--GSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNtiKCH
|    |  .||.   .| |   .   |  || |..       |.| |  ..|.    |.| .| |  ..| |||||. | .|. || .|  .| .  .|.
vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rce

EYYPYNVRGLTVT------IKSKEVLE----LYDRTELTVVHDKygLKEKVIHYYFKKWPDHGvpedPMHLIMfvkKVKAEKRPSYSPIVVHCSAGVGRT
 |.|       ||      |.. .| .    |.  |.| .|  .   .|. . ..   .   .     ..  .   .|    |    |.||..  || ..
yywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdvnnss....dvyspl...rvlrklrnlskpvvvqdilGvska

GTFIGLDLIM-QRLKS-ESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTY
.|.. ... . . |.    |  . ..|. || .|   |..  .| |.|    
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1161-1344 1.4e-17 58.5 In-house 2-198 (199) alignment 
Range on Protein: 1161-1344
Range on HMM: 2-198/199.0
TRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRG------LTVTIKSKEVLELYDRTELTVVHDKY--GLKEKVIHYY
  .. ||||| |  |.. |||.|. .     || | . .  .      |.|    |      |.|| |.  .   |  | | .. .        .. || 
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FKKWPDHGVPEDPMHLIMFVKKVKAE---KRPSYSPIVVHCSAGVGRTGTFIGLDLIMqRLKSESK---INIFETVKKLRFQRMKMVQTQQQYTFLYA
|  | ..  |.  . . . |   .     ..   .|..|||| | | || |. ||. . | . |||   ...||  |.||  |  .. . |.| |.| 
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1163-1344 2.4e-17 57.8 In-house 3-197 (198) alignment 
Range on Protein: 1163-1344
Range on HMM: 3-197/198.0
KKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRG------LTVTIKSKEVLELYDRTELTVVHDKY--GLKEKVIHYYFK
.. ||||| |  |.. |||.|. .     || | . .  .      |.|    |      |.|| |.  .   |  | | .. .        .. || | 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

KWPDHGVPEDPMHLIMFVKKVKAE---KRPSYSPIVVHCSAGVGRTGTFIGLDLIMqRLKSESK---INIFETVKKLRFQRMKMVQTQQQYTFLYA
 | ..  |.  . . . |   .     ..   .|..|||| | | || |. ||. . | . |||   ...||  |.||  |  .. . |.| |.| 
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigv.rsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_hpo-7_pd Subfamily hpo-7 1176-1358 4e-17 57.0 In-house 46-235 (263) alignment 
Range on Protein: 1176-1358
Range on HMM: 46-235/263.0
SVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRG------LTVTIKSKEVLELYDRTELTVVHD-KYGLkEKVIHYYFKKWPDHGVPEDPMHL
 .  |...| | .  |.| .. | | .  || .|.| .  .      ..|.        |    ||. . . |  . ..| || .| |...  ||..   
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkt.htvkhysykgWiekndpelarei

IMFVKKVKAEKrpsysPIVVHCSAGVGRTGTFIGLDLIMQ------RLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIPRAA
.  .| ..  |     ..|||||.|.||.  |   .|. |      .  |  ...  . ...|| .| . ..|  |  |    . ..| .  ..  
lnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakge
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1124-1269 7.4e-17 55.8 In-house 97-242 (244) alignment 
Range on Protein: 1124-1269
Range on HMM: 97-242/244.0
CHKNRYADIFPYDKNRVILDIDAEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTI-KCHEYYPYNVRGLTVTIK
..||| .  .|.| ||| |   . |  ||||||.    |  ||| || |  .. ||||.|.|.  | |.| .    | .      |   .    .|||. 
swknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeedeywpdseplewyeeditvtlt

SKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGV-PEDpmHLI
 .. .     ..| .  |    .. .  .   .||  |  |.|  |.|
drdefknikasnleiesdmneshqaltmfqisnwpsdgttpnd..hfi
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1101-1171 4.2e-15 49.7 In-house 25-95 (95) alignment 
Range on Protein: 1101-1171
Range on HMM: 25-95/95.0
LAREFKEITVVA-LELSYSASELGCHKNRYADIFPYDKNRVILDIDaEGSDYINASFIDGHTRKKEYIATQG
.  ||| |.. .    .  .||    |||. .|||||  ||.|      |||||| |.||..||. |||.||
fdnefksismtsgapytvgsseanipknrflnifpydatrvvlttk.rdsdyinacfvdgyarkncyiaaqg
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1286-1349 9.9e-15 48.7 In-house 1-64 (69) alignment 
Range on Protein: 1286-1349
Range on HMM: 1-64/69.0
IVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYEL
.|||||.| ||||||| . . | |.|||  ..||. |. .|  |  ||  ...| |..    | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1287-1350 2.4e-14 47.4 In-house 1-64 (69) alignment 
Range on Protein: 1287-1350
Range on HMM: 1-64/69.0
VVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELV
|||||.| ||||||| . . | |.|||  ..||. |. .|  |  ||  . .| |..    | .
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1272-1348 6e-14 46.6 In-house 218-293 (297) alignment 
Range on Protein: 1272-1348
Range on HMM: 218-293/297.0
VKKVKAEkRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYE
.. ..||  |   ...|||||||||.|  .  | |...|. .   ..   ...|| || ..||| .|...||  . .
leslrae.mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
0038934 (Phosphotyrosine protein) phosphatases II 1223-1351 7.6e-13 44.0 In-house 54-178 (194) alignment 
Range on Protein: 1223-1351
Range on HMM: 54-178/194.0
SKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEK-RPSYSPIVVHCSAGVGRTGTFIGLDLIMQRlksesKINIFET
 ...  ..| |. . . |.  ...  |.|.   .||.|.. .   |  |.. |.    . .   ..||| ||.|||||...  ||. .     ...  | 
nvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrl.....gmsaeeA

VKKLRFQRMKMVQTQQQYTFLYACTYELVK
.. .|. | .....|...  |.    || |
ialfrekRpgaipnqdyleallkrykelrk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1125-1211 9e-13 42.3 In-house 50-154 (349) alignment 
Range on Protein: 1125-1211
Range on HMM: 50-154/349.0
HKNRYADIFPYDKNRVILDIDAE----------------GSDYINASFIDG--HTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKC
 |||| ||.||.  ||.|    .                  ||||| ..     . .| ||||| | | .| ||...||  .|.... ...  | .  ||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

HEYYP
. |. 
diywq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1254-1347 5.4e-12 39.7 In-house 226-341 (349) alignment 
Range on Protein: 1254-1347
Range on HMM: 226-341/349.0
KKWPDHGVPEDPMHLIMFVKkVKAE-----------KRPSYSPIVVHCSAGVGRTGTFIGLDLIMQ------------RLKSESKINIFETVKKLRFQRM
| |.| ..  .|. ..  .. || .           .    |...|||||| ||||... |||...             |..  |  |. .| .|| ||.
knwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqri

KMVQTQQQYTFLYACTY
 |||  .|. ..| .  
smvqnlaqfiaiyealL
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1134-1260 3.5e-11 37.5 In-house 4-125 (130) alignment 
Range on Protein: 1134-1260
Range on HMM: 4-125/130.0
PYDKNRVIldidaeGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKC-HEYYPYNVRGLTVTIKSKEVLELYDR
... .|.       | .||||||.    | .||. || |  .. ||||.|.|.  | |.| .    | .      | . .    ..||.  ..  .  . 
efevsrlq......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeedeywpdsePlewyeediivtltdrdefknika

TELTVVHDKYGLKEKVIHYYFKKWPDHG
..| . .|    .. .  .   .||  |
snleiesdlneshqaltmfqisnwpsdg
subfamily_PTPDC1_pd Subfamily PTPDC1 1244-1343 2.9e-10 34.9 In-house 78-169 (182) alignment 
Range on Protein: 1244-1343
Range on HMM: 78-169/182.0
LKEKVIHYYFKKWPDHGVPedPMHLIMFVKKVKAEKRPSYsPIVVHCSAGVGRTGTFIGLDLIMQRlksesKINIFETVKKLRFQRMKMVQTQQQYTFLY
|.|. | .|   |.|.||.  ... |. . || |        . ||| || ||||  |   |. ..     ...  ...|..| .| | .||..|  .. 
lmeqgiyvynfgwkDygva..sleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvk
subfamily_eak_pd Subfamily eak 1124-1270 1.1e-09 32.2 In-house 53-205 (332) alignment 
Range on Protein: 1124-1270
Range on HMM: 53-205/332.0
CHKNrYADIFPYDKNRVILDIDA-EGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRG-L---T
 ..|   .| |||.. | |     .   ||||| ..     ..|| |  .. . |. ||.|.|. .   |||. .  | .  |   |.| . |  |    
vnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGi

VTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPE--DPMHLIM
. .. || ..        ..  |     .| || .  | .  .|   | . |  
ldverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1124-1202 1.7e-09 31.6 In-house 38-123 (347) alignment 
Range on Protein: 1124-1202
Range on HMM: 38-123/347.0
CHKNRYADIFPYDKNRVILDIDA-------EGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGN
  |||  |    |. ||.|  .        .   ||||| |     .|||| || | |..| |||.|.   .|  .| . .  . .
lsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikde
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1176-1353 1.7e-09 30.8 In-house 130-312 (346) alignment 
Range on Protein: 1176-1353
Range on HMM: 130-312/346.0
SVMDFWRMILQYNVRVI-VQVTQFREGNTI---KCHEYYPYNVRGLtVTIKSKEVLELYDRTELTVVHDKYGLKEKVIHYYF--KKWPDHGVPEDPMHLI
 | ||| || | ..... . | . .  ||       |   |.  |  . |. .      |  | |.     |  . ||        |     |   . .|
fvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgk.mfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpii

MFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHK
 .... ..||.     . |    | ||. .|||    ...|    . ||.| .|... ||   |..  ||. .||  .. .  |
kmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiark
fn3 Fibronectin type III domain 650-739 5.5e-09 29.2 Pfam-A 2-82 (85) alignment 
Range on Protein: 650-739
Range on HMM: 2-82/85.0
QPESVMLEKSTVSSLLFNWQPPTYTNGPIKYYQAFL-MRHEASyfvpadcaiveQDTKSETKGDP-SVNFTGLAPAVRYMMQVAAQNDFGMG
.|| . ..  | .|| ..|.||.  .|||..|.  . .  . .           ...   ....  ||..||| |  .| ..|.|.|. | |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...........ewkeftvprtttsvtltgLkpgteYefrVqavngageg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1158-1219 7e-09 29.5 In-house 230-288 (440) alignment 
Range on Protein: 1158-1219
Range on HMM: 230-288/440.0
DGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFregNTIKCHEYYPYNVRGLTV
.|...|. .|||| |   .|.||||.. .|..  |. . |.   |   |  |.| | | .| 
egyskknafiatqmpldstvldfwrlvhdyristiimlnql...ndktcsiywpvntrsvtf
PTEN_1 1246-1339 2.3e-08 29.1 In-house 93-182 (196) alignment 
Range on Protein: 1246-1339
Range on HMM: 93-182/196.0
EKVIHYYFkKWPDHGVPEDPMHLIMFVKKVKAEKR-PSYSPIVVHCSAGVGRTGTFIGLDLIMQRLksESKINIFETVKKLRFQRMKMvqTQQQY
..|... |  ..|||.|   ... . ..   . .. |.   ..||| ||.||.|| .   |.  .    .  . .| |.. | ....   . .| 
sgveylhf.pieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk..ltadeAlelvrekRppgapn..spsqe
subfamily_CDC14_pd Subfamily CDC14 1283-1342 9.4e-08 26.3 In-house 263-316 (328) alignment 
Range on Protein: 1283-1342
Range on HMM: 263-316/328.0
YSPIVVHCSAGVGRTGTFIGLDLImQrlksESKINIFETVKKLRFQRMKMVQTQQQyTFL
   |.||| ||.|||||.|.  |. .    . ...  |..  ||. |  .| ..|| .||
eGaiavhCkaGLGrtGtLiacylm.k....hyrftaaeaiawlricrPGsvigpqq.kfl
subfamily_PTEN_pd Subfamily PTEN 1238-1342 1.8e-07 26.3 In-house 72-172 (184) alignment 
Range on Protein: 1238-1342
Range on HMM: 72-172/184.0
VHDKYGLKEKVIHYYFKkwpDHGVPedPMHLI-MFVKKVKAE-KRPSYSPIVVHCSAGVGRTGTFIGLdLIMQRLKSESKINIFETVKKLRFQRMKMVQT
 .|.  ....|..| |.   ||  |  |..|.  .|.....  .. .   .|||| || ||||. |   .....|. |.. .. |  .. |..  | |. 
kydskkfdgrvavypfd...Dhnpp..plelleeivediekwleedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvti

QQQYTFL
  |  ..
PsqrRYv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1126-1201 2.6e-07 24.5 In-house 37-113 (332) alignment 
Range on Protein: 1126-1201
Range on HMM: 37-113/332.0
KNRYADIFPYDKNRVILDIDAEGSDYINASFIDGHTRKKEYIATQGPKPES-VMDFWRMILQYNVRVIVQVTQFREG
 ||   .. .|..|| |  .    |. |||..||...|  || .| |  .     ||||. . .  .|. . .  | 
mnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidek
subfamily_eak_pd Subfamily eak 1278-1355 6e-07 23.2 In-house 232-310 (332) alignment 
Range on Protein: 1278-1355
Range on HMM: 232-310/332.0
EKRPSYSPIVvHCSAGVGRTGTFIGLDLIMQRLKSE--SKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVKHKIP
   ||..||.  .. |  |.|.|. .||... . .       . . . | . .|.. | ...|..|.|    . .... .
htppsfapii.qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnn
0048567 (Phosphotyrosine protein) phosphatases II 1249-1342 1.3e-06 22.9 In-house 38-131 (157) alignment 
Range on Protein: 1249-1342
Range on HMM: 38-131/157.0
IHYYFKKWPDHGvPEDPMHLIMFVKKVKAEK---RPSYSPIVVHCSAGV---GRTGTFIGLDLIMQRlksesKINIFETVKKLRFQRMKMVQTQQQYTFL
  .|.  . |.| | .  .|. |..|..      .    .|.|||.||    |||.|.||. ||.       ...  |... ||. | ..|   ... .|
glvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhl.....gftpeeaiaplrivrpgsvpfrdasyll
subfamily_DSP11_pd Subfamily DSP11 1231-1334 7.1e-06 20.0 In-house 62-168 (178) alignment 
Range on Protein: 1231-1334
Range on HMM: 62-168/178.0
DRTELTVVHDKYGLKEKVIHYYFKKWPDHGVPEDPM--HLIMFVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIM-QRLKSESKINIFETVKKLRF
| |. .  ..|  |... ..|.  . | | ||.. .  ... .||. . ..  . . | |||  || ||| .|   ||  . ...|  |. ||...   .
dltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhsl

QRMKMVQ
.| . ..
erenylk
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1234-1341 8.7e-06 19.4 In-house 183-293 (332) alignment 
Range on Protein: 1234-1341
Range on HMM: 183-293/332.0
ELTVVHDKYGLKEKVIHYYfkKWPDH-GVPEDPMHLI--MFVKKVKAEKRPS--YSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQ
.|||   |   .  ..|.|  .| |   .||  . .   . .. ... |.      ||.. |..|| .   .  .|.|. |.  | .. . ||.  ...|
nltvtekkqdhqtvlmhfy..ewadasklpeymldmrasiklqyirsskktgvcigpimlvcatgvekcaisatidiivsriteehrvgfketmsaikmq

RMKMVQTQQQYTF
|.  ..|   |. 
rfgcfrtvgpyst