Gene Ptp61F in Drosophila melanogaster

Synonym: BEST:LP01280, CG9178, CG9181, DPTP61F, Dmel\CG9181, PTP61F, Ptp-61F, R-PTP 61F, anon-WO0118547.297, anon-WO0140519.98, dPTP61F, dptp61F, ptp61F, Dmel_CG9181, Ptp61F

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN1
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP040_AA protein Get Run
DmelP040_AA_28-298 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN1_pd Subfamily PTPN1 28-308 3.3e-145 477.3 In-house 2-282 (290) alignment
Range on Protein: 28-308
Range on HMM: 2-282/290.0
PQWHRFYKEICETCDREAKekQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAV
 ...|.||||......||.  .|.|.|.....||.|||||||.|||||||.|.|...|||||.||.||.|.|.||||||||..||.|||.|||||||.||
ldkkrlykeiyldirkeas..dfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskav

LMLNKLMEKKQIKCHLYWPNEMGaDKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLS
.||||..||.||||. |||..   .|.|.| ..||.|.|.. |.......|...|..|.||..||...||||||||||.|.||.||||||..||.||.||
vmlnkvvekeqikcaqywPqgee.ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsls

RDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGE---CNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDA
.||||||.||||||||||||||||.|||||.|...   ....|||.|||.||.|||||||||.|||.||.||.|......... 
sdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqk

0050432 (Phosphotyrosine protein) phosphatases II 29-299 2e-88 292.0 In-house 40-301 (308) alignment
Range on Protein: 29-299
Range on HMM: 40-301/308.0
QWHRFYKEICETCDREAkekQFSTSESERHTNRGLNRYRDVNPYDHSRIVLkRGSVDYINANLVQLE--RAERQYILTQGPLVDTVGHFWLMVWEQKSRA
.......|  | ..       ...| ...  |. .|||.|. ||||||..|  .. |||||..|..   . .|..|.||||| .||..|| |||||..| 
dlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

VLMLNKLMEKKQIKCHLYWPNEMG-ADKALKlphvKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGc
. ||.||.|....||. |||.|.|   .  .    |.||.|.. |.......|...||.|....||.|..||||.|||.|.|.||...|.||..||.|  
IvmLtklvengrekcaqYwplelgggsleyg....kftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.

lsRDvGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
  .. || |||||||.||.|||...|..| ...| |...| .... ||..|.| .|| .|. | |.|..| .|.
..pg.gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

0036941 (Phosphotyrosine protein) phosphatases II 47-299 1.6e-85 282.3 In-house 26-279 (297) alignment
Range on Protein: 47-299
Range on HMM: 26-279/297.0
EKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWP
 ...|.| .... |. .|||.|. ||||.|..|. .. |||||..|.. . .|..|.||||| .||..|| |||||... ..||..|.|.  .||. |||
lllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywp

NEMGADKALklphVKLTVELVRLET--YQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRS
.|.|  .       ..||.|.. |.  ......|....||.....||.|..||||.|||.|.|.||. .|.|...||.   |... || .||||||.|||
leegeslty....gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

GTFCLVDCCLVLID---KYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
|||...|..| ...   |.|.... .....||..|.| .|| .|. | |.|..| .||
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk

0047943 (Phosphotyrosine protein) phosphatases II 30-297 2.7e-84 278.2 In-house 14-272 (273) alignment
Range on Protein: 30-297
Range on HMM: 14-272/273.0
WHRFYKEICETCDreakekQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLM
... .........      ....| ...  |. .|||.|. ||||||..|. |. |||||..|.. . .|..|.||||| .||..|| |||||..| . |
lleefelllslkp......lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

LNKLMEKKQIKCHLYWPNEMGAdkaLKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRD
|..|.|....||. |||.|.|    |.| . |.||.|.. ||..... | ..||.|.|..||.|..||||.|||.|.|.|.. .|.|...||.    ...
LtelvelgrekcaqYwplegge...lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

VGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
 || |||||||.||.|||...|..| .. |.|. .| .... |||.|.| .|| .|. | |.|..| .
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0051299 (Phosphotyrosine protein) phosphatases II 33-297 6.3e-83 273.8 In-house 28-286 (288) alignment
Range on Protein: 33-297
Range on HMM: 28-286/288.0
FYKEICETCDReakekqFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVL
 ..|... .        ...| . .  |.  |||.|. ||||||..|.     .. |||||..... . .|..|.||||| .||..|| |||||..| . 
efeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIv

MLNKLMEKKQIKCHLYWPNemgaDKALKLPHvkLTVELVRLETYQNFVRRWFKLTDL----ETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSG
||.||.|....||. |||.    .. |.. .  .||.|.. |...... |....|.|     ...||.|..||||.|||.|.|.||...|.||..||.. 
mltklvelgrekcaqYwpl....ggsltygd..itvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

ClsRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
    . || |||||||.||.|||...|..| ...| |...| .... ||..|.|..|| .|. | |.|..| .
a..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0046845 (Phosphotyrosine protein) phosphatases II 49-299 1.3e-82 272.7 In-house 17-276 (284) alignment
Range on Protein: 49-299
Range on HMM: 17-276/284.0
QFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR-----GSVDYINANLVQLE-----RAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQ
 .|.| . .  |. .|||.|. ||||||..||.     .. |||||..|.       . ....|.||||| .||..|| |||||..| . ||..|.|...
llslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengr

IKCHLYWPNEmGADKALKLphvkLTVELVRLETYQNFVRRWFKLTDLE-TQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHC
.||. |||.| |  . ..     .||.|.. |.......|...||.|. |..||.|..||||.|||.|.|.||. .|.||..||..   . . || ||||
ekcaqYwple.gevltygd....ftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHC

SAGIGRSGTFCLVDCCLVLIDKYG---ECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
|||.||.|||...|..| ...| |   ...| .... ||..|.| .|| .|. | |.|..| .|.
saGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

0040438 (Phosphotyrosine protein) phosphatases II 31-306 1.4e-82 272.8 In-house 18-285 (317) alignment
Range on Protein: 31-306
Range on HMM: 18-285/317.0
HRFYKEICETCDReakeKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRA
.....| .. ..     |  ..|..|.  |...|||.|. ||||||..|.  .     |||||..|.  .  |..|.||||| .||..|| |||||... 
talleefedllsl....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

VLMLNKLMEKKQIKCHLYWPNemgaDKALKLPHvkLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCl
..||..|.|....||. |||.    .. |.  .  .||.|.  |...... |.....||....||.|..||||.|||.|.|.||. .|.||..||..   
ivmLteleelgrekcaqYwpl....getltygd..ftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.

sRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFL
 .. || .||||||.||.|||......| ...|.|...| ....|||..|.| .|| .|. | |.|..| .|. .  . .
.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepa

subfamily_PTPRD_pd Subfamily PTPRD 46-300 1.2e-80 266.8 In-house 34-284 (564) alignment
Range on Protein: 46-300
Range on HMM: 34-284/564.0
KEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKC
...||...... ..|.  ||| .. .|||||.||..     . |||||. ..  |....|| ||||| .|.  || |||||.|. . ||.|| ||.. ||
egqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkc

HLYWPNEmGadkalKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGI
| |||.. |     .  . .|||.|.  |...... | |||.. ....|||| |||.| ||| |.| |....|.....||..   ..| || |||||||.
hkYWPek.g.....tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln..epdagPivVhCSaGV

GRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKL
||.|||. .|..|  | . .  .. ... .||. |  ..|| .|  | ..|| | ... 
GRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg

DSPc_SM00195 41-297 3e-79 261.4 In-house 9-262 (263) alignment
Range on Protein: 41-297
Range on HMM: 9-262/263.0
CDREAKEKqfSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEK
 ......|  .|.|.|.. |.  |||... ||||.|. ||.       |||||| ..... ...||.||||| .|| .|| ||||.|.. ..||.. .|.
leestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

KQIKCHLYWPNEMGADKALKlphvKLTVELVRLETYQ-NFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSrdVGPAVV
...||. |||.|.|  .  .    |..|.||. |... ....| ..||  .....|.| |..|..||| |.|.|.. .|..|..|. |   |   || ||
gkekcdrywpeesggketfg....kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
|||||.||.|||...|..|  .... . .......|||. |.|..|| .|. | |.||.| |
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 41-297 3e-79 261.4 In-house 9-262 (263) alignment
Range on Protein: 41-297
Range on HMM: 9-262/263.0
CDREAKEKqfSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEK
 ......|  .|.|.|.. |.  |||... ||||.|. ||.       |||||| ..... ...||.||||| .|| .|| ||||.|.. ..||.. .|.
leestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen

KQIKCHLYWPNEMGADKALKlphvKLTVELVRLETYQ-NFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSrdVGPAVV
...||. |||.|.|  .  .    |..|.||. |... ....| ..||  .....|.| |..|..||| |.|.|.. .|..|..|. |   |   || ||
gkekcdrywpeesggketfg....kisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpivV

HCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
|||||.||.|||...|..|  .... . .......|||. |.|..|| .|. | |.||.| |
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0045450 (Phosphotyrosine protein) phosphatases II 28-296 4.6e-79 261.6 In-house 24-303 (307) alignment
Range on Protein: 28-296
Range on HMM: 24-303/307.0
PQWHRFYKEICETCDREAKEkQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR-----GSVDYINANLV--------QLERAERQYILTQGPLVDTVGH
  .....||. . .. . .   ...|....  |. .|||.|. ||||.|..|.      .. |||||. |        .  .  |..|.||||| .|| .
dfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetved

FWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEmGADKALKLphvkLTVELVRLETYQNFVRRWFKLTDL-ETQQSREVMQFHYTTWPDFGIPSSPNAF
|| |.|||......||..|.|....||. |||.| |  .  .     .||.|.. |.......|....||| .|..||.|..||||.|||.|.|.|.. .
FwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

LKFLQQVRD------SGclsrdvGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGE---CNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
|.|...||.      .|      || .||||||.||.|||.. . .|....| |.   ... .....||. |.| .|. .|. | |.|..| 
ldfieevrkaleelpkg......gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0039614 (Phosphotyrosine protein) phosphatases II 26-300 1.2e-77 256.6 In-house 27-292 (297) alignment
Range on Protein: 26-300
Range on HMM: 27-292/297.0
KGPQWHRFYKEICETCDREAkekqfSTSESERHTNRGLNRYRDVNPYDHSRIVLKR-----GSVDYINANLVQLERA-ERQYILTQGPLVDTVGHFWLMV
|  . .....|  | ..        ..|....  |. .|||.|. ||||||..||       . |||||..|.  .   |..|.||||| .||..|| ||
kansktllllefeellslkp.....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WEQKSRAVLMLNKLMEKKQiKCHLYWPNEMGadkalklPHVKLTVELVRLETYQNFVRRWFKLTDleTQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQ
|||......||.||.|... ||. |||.|.|        . ..||.|.. |.......|....|.  ...||.|..|.|| |||.|.|.|.. .|.||..
weqgvtvivmLtklvelgr.kcaqywpeegg.......tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflel

VRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKL
||.    ... || .||||||.||.|||.. . .| ...|.|. .| ....|||..|.| .|| .|. | |.|..| .|. 
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0043336 (Phosphotyrosine protein) phosphatases II 31-295 1.8e-74 246.0 In-house 20-275 (278) alignment
Range on Protein: 31-295
Range on HMM: 20-275/278.0
HRFYKEICETCDREAkekqFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRA
.....|  | ..       ...| ...  |. .|||.|. ||||||..|.  .     |||||..| . .  |..|.||||| .||..|| ||||.... 
tllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtt

VLMLNKLMEKKQIKCHLYWPnemgaDKALKLPHvkLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCl
..||..|.|....||. |||     .. |.  .  .||.|.. |.......| ...|.| . .||.|...||. |||.|.|.|.. .|.||..||.    
ivmLtelvelgrvkcaqYwp.....ggsltygd..ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.

sRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
  . || .||||||.||.|||.... .| ...|.|. .. ....|||..|.| .|| .|. | |.|..|
.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_PTPN13_pd Subfamily PTPN13 51-300 1.2e-73 242.8 In-house 28-272 (273) alignment
Range on Protein: 51-300
Range on HMM: 28-272/273.0
STSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVdYINANLVQLE--RAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNE
........ |.  ||||.| |||..|. |.  .  ||||.|....    | .||..|||| .||  ||.||||||.. . |. .  ||...||| |||..
tcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

MGadKALKLpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgcLSRDVGPAVVHCSAGIGRSGTFC
..  | ||. . .|.|||.... ...|| | ....|.|...||||.......||| |.|||.. .|.|...||    | .| || |||||||||||||. 
kn..kklkv.snrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr...lqtdagPivvhcsaGiGrsGtli

LVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKL
 .|  | ||..  | .|.... .||  | |..|| ||  | |.||.| .|.|
tidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlksl

Y_phosphatase Protein-tyrosine phosphatase 61-295 2e-73 242.0 Pfam-A 2-235 (235) alignment
Range on Protein: 61-295
Range on HMM: 2-235/235.0
RGLNRYRDVNPYDHSRIVL--KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGAdkalKLP
.  |||.|. |||..|. |  . |. |||||| |.. . ....|.||||| .|...|| |||..|.... ||..|.||.. ||. |||.|..     .| 
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee....slt

HVKLTVELV-RLE-TYQNFVRRWFKLTDLETQQ-SREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGIGRSGTFCLVDCCLV
. ...|||. . .   .... | ..|.. .... .|||.|.|||.||| |.|.||...|.....|. |   . . || |||||||.||.|||...|..| 
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
 ... .| .| ....|||. |.|..|...|. | |.||.|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 61-295 2e-73 242.0 In-house 2-235 (235) alignment
Range on Protein: 61-295
Range on HMM: 2-235/235.0
RGLNRYRDVNPYDHSRIVL--KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGAdkalKLP
.  |||.|. |||..|. |  . |. |||||| |.. . ....|.||||| .|...|| |||..|.... ||..|.||.. ||. |||.|..     .| 
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee....slt

HVKLTVELV-RLE-TYQNFVRRWFKLTDLETQQ-SREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGIGRSGTFCLVDCCLV
. ...|||. . .   .... | ..|.. .... .|||.|.|||.||| |.|.||...|.....|. |   . . || |||||||.||.|||...|..| 
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
 ... .| .| ....|||. |.|..|...|. | |.||.|
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_PTPRB_pd Subfamily PTPRB 47-299 6.9e-72 236.9 In-house 38-287 (293) alignment
Range on Protein: 47-299
Range on HMM: 38-287/293.0
EKQFSTSESERHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCH
.|. ... .|...||  |||... ||||||. |    .. . |||||| ..  ...|..| ||||| .|| .|| ||||.||....|| .|.|| ..||.
gkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCe

LYWPNEmgadkALKLPHVKLTVELVRLETYQNFVRRWFKLTDleTQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIG
 |||..          . ...|.||  |.....| | .|..   ....|.|.|.|.|.|||.|.|......|.|...||..   . . .| |||||||.|
eYWPad.....eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvG

RSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
|.|||  .|  |  |..    ..  ...|||. |. |.|| .|  | .|.... ..|
RtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

0045098 (Phosphotyrosine protein) phosphatases II 53-300 1.1e-71 236.7 In-house 26-275 (278) alignment
Range on Protein: 53-300
Range on HMM: 26-275/278.0
SESERHTNRGLNRYRDVNPYDHSRIVlkrgsvDYINANLVQLEraERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNemgaD
... .  |. .|||.|. ||||||..      |||||....     ...|.||||| .|| .|| |.||.......||..|.|....||. |||.    .
tpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe....g

KALKLPHvkLTVELVRLETYQNFVRRWFKLTDL----ETQQSREVMQFHYTTWPDFGIPSSP--NAFLKFLQQVRDSGC------------LSRDvGPAV
. |   .  .||.|.  |...... |....|.|    |. .||.| ..||..|||.|.||.|  . ||..|...|.               |... || .
gsltygd..ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg.gpvl

VHCSAGIGRSGTFCLVDCCLVLIdKyGECNVSKVLCELRSYRMG-LIQTADQLDFSYQAIIEGIKKL
||||||.||.||.......| |. . | ... ....||||.|.|  .|. .|. | |....| ....
VHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllrg

0040439 (Phosphotyrosine protein) phosphatases II 52-297 1.1e-70 233.4 In-house 3-246 (249) alignment
Range on Protein: 52-297
Range on HMM: 3-246/249.0
TSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPN
.|....  |. .|||.|. ||||||..|.        |||||... . .  |..|.||||| .||..|| |.||.......||..|.|....||. |||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

emgaDKALKLPHvkLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTF
    .. |.  .  .||.|.. |.......| ..||.|....||.|....|| |||.|.|.|.. .|.|...||.     .. || .||||||.||.|||
....ggsleygd..ftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

CLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
.. . .| ...|... ..  ....|||.|.| .|. .|. | |.|..| .
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

0042113 (Phosphotyrosine protein) phosphatases II 54-296 4.6e-70 231.1 In-house 3-242 (245) alignment
Range on Protein: 54-296
Range on HMM: 3-242/245.0
ESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNem
 ...  |. .|||.|. ||||.|..|.  .    .|||||..| . |  ...|.||||| .||..|| |.||.......||....|....||. |||.  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

gaDKALKLPHvkLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDvGPAVVHCSAGIGRSGTFCL
  .  |.  .  .||.|.. |.......| ...|.| . .||||...||. |||.|.|.... .|.||. ||.    ... || .||||||.||.|||..
..gesltygd..ftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsn.gpvlVHCsaGvgRtGtfia

VDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
.. .| ...|... .. ... ||||.|.| .|| .|. | |.|..| 
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

subfamily_PTPN3_pd Subfamily PTPN3 46-296 1.6e-69 228.9 In-house 27-274 (280) alignment
Range on Protein: 46-296
Range on HMM: 27-274/280.0
KEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAE----RQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKC
|... ..|.. .  |   |||||. |||. |. || ...|||||| |..|        .|| ||||| .|. .|| |||||||. ..||  |.|. ..||
kkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

HLYWPNemgADKALKLPhvKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGI
| |||.    .. |..   ...|.. . .. ...| | . |.| ||...|...|. |. ||| |.|.... ||.|...||.    | .  | ||||||||
hqyWPe...tedeleyg..efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..sgkeePvvvhCsaGi

GRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
||.| . |.. .| ||..  . .. ... ..|  |. |.|||.|  |  .||.. 
grtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_PTPN6_pd Subfamily PTPN6 35-299 3.3e-68 224.9 In-house 29-299 (306) alignment
Range on Protein: 35-299
Range on HMM: 29-299/306.0
KEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSV---DYINANLVQ--LERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLM
.|  |. ..|...|..| .|... .|.  |||. . |.||.|..||. ||   |||||| ..  ..  ...|| ||| | .||  || |||...|| ..|
eeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivm

LNKLMEKKQIKCHLYWPNEMGADKalklpHVKLTVELVRLETYQNFVRRWFKLTD-LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSR
. | .|. . ||  |||.|   ..     . |..|. |. .. .... | ....   . ...|||.|.|...||| |.|..|.|.|.||..|.     ..
ttkevErgkekCarYWPdeeekee.....yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele

--DVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYG---ECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
  . || |||||||||| ||| ..|. | || | |   .... |.   .|..| ||.||..|  | |.|| . |..
eaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 46-298 1.7e-67 222.7 In-house 32-281 (318) alignment
Range on Protein: 46-298
Range on HMM: 32-281/318.0
KEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKC
.|..... .|   .|.  ||| .. .|||.|. |.      . |||||| ..  |....|| .|.|| .|.  || |||||.|. ..|| ...|. ..|.
seetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakv

HLYWPNEMGADkalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGcLSRDVGPAVVHCSAGI
| |||..          . ||.|||    .....| | ||.|  |...||.| |.|||.||| |.|.|.  .|....||.    .. ..|| |||||||.
hryWPskgsrs......ygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaq.qksgagpivvhCsaGv

GRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
|| |.|. ||  |  | . .  .| ..  .||. |  ..|| || .| |....| ..
GrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala

subfamily_PTPN9_pd Subfamily PTPN9 53-296 5.2e-67 221.0 In-house 35-289 (297) alignment
Range on Protein: 53-296
Range on HMM: 35-289/297.0
SESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNE
  |. ..|   ||| ||  ||..|.||..       |||||| |.  . .. .| |||||  ||  ||.|||||. . ..|  ...|....||  |||.|
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

MGAdkalKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDS-GCLSRDVG----------PAVVHC
 ..       ...|.|. |  |...... | ..... .|..||.|. | ...|||.|.||| ...|..|..||.  .......|          | ||||
ees....saefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhc

SAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
||||||.|||. .| ||  ... | ..| ...  ||. |   ||| .|  | |.|..| 
saGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 49-299 6.8e-67 220.5 In-house 30-278 (281) alignment
Range on Protein: 49-299
Range on HMM: 30-278/281.0
QFSTSESERHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLY
. ... |... |.  |||...  ||..|...    .  . |||||| |.  . |..|| ||||. ... .|| |||||| .|. |. . .|. ..||| |
dntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrY

WPNEMGadkalKLPHVKLTVELVRLETYQNFVRRWFKLtDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDvGPAVVHCSAGIGRS
||..       .|   ..||. .. |. .....| ||| . |. ..||| |..||.||| |.|......|.| ..|.     ...  | |.|||||.||.
WPddns.....elkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.aplvihCsaGvGrt

GTFCLVDCCLVLI-DKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
||.  .|  .  . ..  | .|. |. |||  |. ..||  | .| |.|... ..|
GtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

0037934 (Phosphotyrosine protein) phosphatases II 56-295 1.3e-66 220.0 In-house 6-240 (243) alignment
Range on Protein: 56-295
Range on HMM: 6-240/243.0
ERHTNRGLNRYRDVNPYDHSRIVLkRGsVDYINANLVQLEraeRQYILTQGPLVDTVGH----FWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGA
 .  |.  |||.|. ||||||..|  |  |||||||..     ...|.||||| .|| .    || |.||.......||..|.|....||. |||.|.  
llpenlsknrysdilpydhsrvkl.eg.sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevty

DKalklphvkLTVELVRLETYQNFVRRWFKLTDLE-TQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSG-------CLSRDvGPAVVHCSAGIGR
..        .||.|.  |...... | ..|. |. ....|.|...||. |||.|.|.||. .|.||..||.         .|... || .||||||.||
gd........ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg.gpvlVHCsaGvgR

SGTFCLVDCCLVLIdkygECNVSKVLCELRSYRMG-LIQTADQLDFSYQAIIE
.||... . .| |.    .... .....||. |.|  .|| .|. | |.|..|
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_PTPN23_pd Subfamily PTPN23 21-301 2.7e-65 215.0 In-house 8-284 (288) alignment
Range on Protein: 21-301
Range on HMM: 8-284/288.0
AEYKDKGPQWHRFYKEICETCDREakEKQFSTSESERHTNRglNRYRDVNPYDHSRIVLKRGSVDYINANLVQ-LERAERQYILTQGPLVDTVGHFWLMV
 .. |   . .. .||. .. |.|   ...|.. .......  ||.||. ||||.|..|. .  |||||  |. |     ..| ||.||  |.. |||||
rkmldgktaldkkfkeleqkqdke..arkrsiaiaklysek..nrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKAlklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQ
.||||. . || .  |... |.. |||.. |. .     . .|.| | . .. ...|.| .||. |.... ..|.  ..|.||..|.|.||. .|.||..
yeqkssviVmllskeelgkpkvdrYwPedkgetvk....fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

VRD--SGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLID-KYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLH
|..  .    .   | |||||||.||.|.|.|| . .  .. . |  .. .|.  ||  |   .|. .|| |||.|..| ...  
vesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 46-295 1.7e-64 212.6 In-house 33-277 (288) alignment
Range on Protein: 46-295
Range on HMM: 33-277/288.0
KEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKC
 ||. |.. ...  |   ||||.. |||. |. ||      . |||||. .. |. ...|| ||||| |||..|| .|.|.|.  ..||..|.|. . ||
lektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkC

HLYWPNEmgaDKALKlpHVKLTVELVRLETYQNFVRRWFKLTdlETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGI
. |||..   ||  .  . ..||.||  .. ..|| | . |    ... .|. |..|..||| |.| | . .|..|.||  .   . |.|| .||||||.
eeYWPda...dkpkn..yGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvan..qadtgpiivhCsaGv

GRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
||.|||  .|. .  ....   .|  ....||  |. |.||  |  | |.....
GrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_PTPN12_pd Subfamily PTPN12 30-299 2.6e-64 211.9 In-house 10-279 (290) alignment
Range on Protein: 30-299
Range on HMM: 10-279/290.0
WHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSR
... .... .. ..  .||..||...|...|.  |||.|. |||.||..|..       ||||||...    . .|| .|||| .|.  || |.||.. .
fakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknve

AVLMLNKLMEKKQIKCHLYWPNEMGADKAlkLPHVKLTVELVRLeTYQNFVRRWFKLTDLetQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGC
 |.|. ...| ...||. |||.|.. .      ....|.|  .  . ..|. | .|..    ..||.| ||||| ||| |.|||..  |.....||.   
ivvmaCrevelgkkkCerYWpeegeeele..fgefevtleeeka.vdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

lsRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKY---GECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
  ..  | |||||||.|| || . .|    |. .     | .| ... |||  |  |.|| .|  . |.|..| ..|
..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 44-298 4.6e-64 211.5 In-house 40-291 (298) alignment
Range on Protein: 44-298
Range on HMM: 40-291/298.0
EAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQI
. . ...... .....|.  ||| |. ..|.||.||..       |||||  ..  . .  .|.||.||. ||  || ||.|... .. ||..| |....
sseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldkt

KCHLYWPNEMGADkalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgcLSRDVG--PAVVHC
|.| |||.|  .       . ..||.| . |.. ... | .|... .....||| |.|.|.||| |.|.  .. |..|..||      .. |  | .|.|
kyhkywPdegket......ygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra...sqqqagnkpvivqC

SAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
|||.||||||. .|  |  . |     | .|.  ||  |.|..|| .|  | |.|..| ..
saGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald

subfamily_PTPRG_pd Subfamily PTPRG 39-298 5.3e-62 204.8 In-house 26-288 (563) alignment
Range on Protein: 39-298
Range on HMM: 26-288/563.0
ETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR-----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKL
|   .| ..|.. .. |... |.  ||| .. .||.||. |.      .. |||||| ..  . ....| ||||| ||.  || |.|||..  . |. .|
ealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnl

MEKKQIKCHLYWPNemGADKALKLPHVKLT-VELVRLETYQNFVRRWFKLTDLET-QQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVrdSGCLSRDVG
 |... ||. |||.     . ..  .|.|.  | . | | ...| . .|| . .  .. ..|.|.|||.||| | |...   |.| ..   |    ...|
vergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..saankaeaG

PAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
| |||||||.||.||.. .|  |  | .    || ..|  .|. |  |.|| .|  | ..|..| |.
PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 55-297 9.8e-62 203.8 In-house 41-283 (305) alignment
Range on Protein: 55-297
Range on HMM: 41-283/305.0
SERHTNRGLNRYRDVNPYDHSRIVLKR-GS---VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMG
 ....|.  ||.......|..|| |.   |    |||||. |.  . . .||..|||| .||  || ...| | . ..|| ||.| .. ||. |||....
gkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpeskt

ADKALklphVKLTVELVRLETYQNFVRRWFKLTD-LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVgPAVVHCSAGIGRSGTFCL
 .| .     ...|||   .|..... | .|..   | ..|| |.|.. |.||| |.| .. ..|.....|. .   ...| | .||||||.||.|.|. 
ekkef....gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgv.pllVhCsagvgRtGvfia

VDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
||  |  . | .. .| .|| .||| ||...|| || .| ..|. | |
vdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli

subfamily_PTPRK_pd Subfamily PTPRK 55-296 1.5e-60 199.7 In-house 38-276 (314) alignment
Range on Protein: 55-296
Range on HMM: 38-276/314.0
SERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMg
. .. ||  ||. |. .||.||..|.      | |||||.|.   .  ...| ||||| .||  || .|..... ...||..|.|. ..||  |||..  
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt.

adkalKLpHVKLTVELVRLETYQNFVRRWFKLTD--LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLsrDVGPAVVHCSAGIGRSGTFC
     .  . .. ||||. |. ...| | |...      .. ||| ||....|||...| | ...||....|  |     . |. ||||||| ||.|||.
.....ev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfi

LVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
 .|  | .|.. |  .| ..  .|||... ...| .|  | |..|.| 
aidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 49-298 1.8e-60 199.2 In-house 9-265 (270) alignment
Range on Protein: 49-298
Range on HMM: 9-265/270.0
QFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGSV----DYINANLVQ-LERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHL
. ...  |  ... ||||.|. |  ..|..|.. .      ||||| |.  . ....|| ..|||  |. .|| |.||.|..|..|. .|.|| . ||  
tsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCer

YWPNEMGadKALKLPHVKLTVELVRLETYQNFVRRWFKLTdlETQQSREVMQFHYTTWPDFGIPSSPN------AFLKFLQQVRDSGCLSRDVGPAVVHC
|||.| .  . .|| . |..|  .  |  . ....  .|.  |. ..|... |.|.|||| |.|....        || |..|| |    .. .| .|||
YWpaepk..ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHc

SAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
|||.||.||. ..| .. |... ....| ... ||| .|| |.|. .|  | |.|..| ..
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_PTPRA_pd Subfamily PTPRA 49-295 4.9e-60 198.1 In-house 47-293 (330) alignment
Range on Protein: 49-295
Range on HMM: 47-293/330.0
QFSTSESERHTNRGLNRYRDVNPYDHSRIVLK--RG--SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLY
| .   ...  |.  ||. .. |||.||..|   .|  . |||||  ..  .   ..| .|||. .||  || |.||||| ...|| .| |.|. ||. |
qatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy

WPNEmGAdkalkLPHVKLTVELVRLETYQNFVRRWFKLTD----LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgCLSRDVGPAVVHCSAG
||.| |.     . . ...||.   .  ...  | | ...     . ..|| | |||.|.|||.|.|. |   ||.|..|.   .  .  || |||||||
wPde.Gl.....vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk..lnqqsagpivvhcsaG

IGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
.||.|||. .|  |  .   .  .| ... .||  |  ..||  |  | |... |
vGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle

subfamily_Ptp69D_pd Subfamily Ptp69D 44-299 8.3e-60 197.5 In-house 32-288 (307) alignment
Range on Protein: 44-299
Range on HMM: 32-288/307.0
EAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQI
||.| . ||. ||.. |   ||| |. ..|. |..||.     . |||||. ..  . ....|  |.|.  |.| || |..||..  . || .| ||.. 
eareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrk

KCHLYWPNEmgadKALKLPhvKLTVELVRLETYQNFVRRWFKLTDLE-----TQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSrdVGPAV
||. |||.|    .  .    .. |.||. |. .....| ....  .      ..||.|.|.|||.|.|. .| .... ||...|||.   |.   .| |
kcakYWpie....devqyg..dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..rsPiv

VHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
|||||| ||||.|  .|  |  . .  . .. .. ..||| |  |.|  .|  | |.|... ...
vhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 48-298 1e-58 193.9 In-house 36-284 (319) alignment
Range on Protein: 48-298
Range on HMM: 36-284/319.0
KQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHL
........... |.  |||... .||..|.||.      . |||||. ..  . ....| ||.|| .|.  || ||||..|  |.||.|| || ..|.. 
vndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkk

YWPNEMGADkalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQ-SREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGClSRDVGPAVVHCSAGIG
|||.|   .        .|.|.|   |  .... | .||  . ..  .|||..|.|| ||| ..| .  . |..|...| |     . || |||||||.|
ywpeenfee......yGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksre.ktqsgPivvhCsaGvG

RSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
| |||. .|  |  . . |  .| ..  .||  |  ..|. .|  | |.|..| ..
RtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 55-299 1.1e-58 193.5 In-house 4-244 (250) alignment
Range on Protein: 55-299
Range on HMM: 4-244/250.0
SERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIkCHLYWPNEmg
...  |.  ||| |. ..|.||.||.. .     |||||  ..  . .. .| |||||..|. .|| ||.|.|| ...||..| |...  .| ||| |  
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..

adKALKLPHVklTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSrDVGPAVVHCSAGIGRSGTFCLV
  || |  .|  ||.|   |.. ... | .||.  . ...| | |.|...||| |.|   .| |..|..|. |   . . .| .|.||||.||||.|. .
..kaekyGdv..tvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa.gnaPvivqCsaGvgrsGafiai

DCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
|. |  . |    .| ||.  ||  |.. ... .|  | |..|.. .. 
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 59-299 4.9e-57 188.1 In-house 27-270 (274) alignment
Range on Protein: 59-299
Range on HMM: 27-270/274.0
TNRGLNRYRDVNPYDHSRIVLKRG-----SVDYINANLVQ-LERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGAD
 .   |||... | ..||..|..        .||||| ..  .. .. |. |||||. ||  ||.|....... ..|| || |... ||. |.|.. ...
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

KALKlpHVKLTVELVRLETYQNFVRRWFKLTDLETqqSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRD-VGPAVVHCSAGIGRSGTFCLVD
 . .  . .. .. .   . ...  | . |  ||   .|.|. . || |||   | ..|..|.....|..|   .   ..|.|||||||||| | |  ..
iser..ygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

CCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
 ..  ... .  .| |. |.||  | |..||..| .. ..|...  |.
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr

subfamily_PTPN14_pd Subfamily PTPN14 44-299 9.3e-57 187.3 In-house 35-298 (300) alignment
Range on Protein: 44-299
Range on HMM: 35-298/300.0
EAKEKQFSTSESErhTNRGLNRYRDVNPYDHSRIVL---KRGSVDYINANLVQLE--RAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQ
. .. ..||.. .   |   ||..|| ||...|. |   |  | .||||  ..     .||.|| .||||  ||  || |||||. . ..|| .  |. .
kredallstaklp..enaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgk

IKCHLYWPNEMGADKALKLPHVKLTVELVrlETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSR-------DVG
 |.. |.|..    | ..  . |.| ...  |. . .. . .||  | ... |.|. . || ||| |.|. .. ||..|..|.     .           
eksfkyfPkleskkktvefgkfkvttkfs..edsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskP

PAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
| .||||||.||.|   |.|  .  ...  | .. |||  ||  || |.||  |  | |...|. .|.
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 44-295 8.4e-54 177.3 In-house 22-275 (287) alignment
Range on Protein: 44-295
Range on HMM: 22-275/287.0
EAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR---GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIK
...   .   ..|   .   ||| || |.|..|..|       .|||||| |   . . ..| .|||.  ||. || .|.|..| .|... . .|. . |
dsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlk

CHLYWPNEmgaDKALKLPHVKLTVeLVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSR---DVGPAVVHC
|. |||.    .. ...    ... | .     ..  | ..| ||||...| | |... .||| ... .  ....|  .|..   |.|   .||| |||.
cykywPer...evPmrvGGysvvl.ldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhd

SAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
..||||||..  .  ..    . |. .|..|.  || || .|.|.. || ..|.|.. 
dvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 57-296 2.6e-53 176.0 In-house 46-278 (315) alignment
Range on Protein: 57-296
Range on HMM: 46-278/315.0
RHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEmgad
.  |.  ||| .. .||.||. |    .    ||.|||...    .|.|| .|||.| .|. || .|.|..   ..||..|.|... |.  |||..    
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk....

kalKLPHVKLTVELVRLETYQNFVRRWFklTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGclSRDVGPAVVHCSAGIGRSGTFCLVDC
   |. . |.|| ..  | ....  | .  .    .. |||.|.|||.||| |.| .  ..... ..|.       .||. |||||||.||.|||. .|.
...kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhh..tnsvgaivvhcsaGvGrtGtfitlda

CLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
 |  ..     .| ...  .|. |....|.|.| .| |.|..| 
vldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_PTPRN_pd Subfamily PTPRN 31-300 1.3e-51 170.1 In-house 29-295 (297) alignment
Range on Protein: 31-300
Range on HMM: 29-295/297.0
HRFYKEICETCDREAKEKQFSTSESERhtNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLV-QLERAERQYILTQGPLVDTVGHFWLMVWEQKSR
.|. ||    |. ||...  .....|.  |   ||...| ||||||. ||.     . |||||  . . .  .  || ||||| .|| .|| ||||| . 
drlekewealcayeaepstkevakaek..nvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

AVLMLNKLMEKKQIKCHLYWPNEmGAdKALKLPHVKLTVELVRLETYqnfVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgC
 ...| .| |.   .|. |||.| |. .  ..  |.|  | .  . |   . | | | .|.|...| | |||. .||. |.|.|....|.| ..|    .
vivnltrleeegvkqckrywpde.Gs.evyhiyevhlvsehiwcddy...lvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk..s

LSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDK-YGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKL
      | |||||.| ||.|...|.|  |  . |   | ...  |  ||  | ||..| ||..| ..|..| ....
yrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnai

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 58-297 5.7e-51 168.2 In-house 45-278 (287) alignment
Range on Protein: 58-297
Range on HMM: 45-278/287.0
HTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadkaLKL
  |. .||.... ..|  |..||    |||||  ..  . ....|....|...|.  || ......  |..|| ...|... .|. |||.|      . |
sqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks....vvl

phVKLTVELVRLETYQNFVRRWFKLTDLE-TQQSREVMQFHYTTWPDFG-IPSSPNAFLKFLQQVRDSgcLSRDVGPAVVHCSAGIGRSGTFCLVDCCLV
   . ..||.  |...... | ....  . ... ..|.|...|.|.. | ...    .| . ....      |  .. |||||...|||..|| ..  . 
..GeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq..rkrgntsivvhCsdtvGrsamfcaaattin

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
  .. |  .| .|| . |  ..| .||..|  | .....| .
kckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 53-298 4.1e-50 165.4 In-house 37-278 (315) alignment
Range on Protein: 53-298
Range on HMM: 37-278/315.0
SESERHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNE
  .  . |   |||... |.|..|..|    .    |||||  ..    .. || .||||  .|  || ||...|  .. |..|. |  .|||  |||..
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

MgADKAlklPHVKLTVELVRLETYQNFVRRwfKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSgcLSRDVGPAVVHCSAGIGRSGTFC
  || .      .. |||. ||.  . | |  ||.  ....|| | ||..| ||| |..    ..||....|. .    ..  . .||||||.||.| ..
k.adsv...efGsikvellsleadtdgvar..klvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvi

LVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
 .| ..  | .    .| ... .||. |. |.|| ..  | |.|. | ..
sidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 46-299 4.6e-50 165.1 In-house 32-285 (290) alignment
Range on Protein: 46-299
Range on HMM: 32-285/290.0
KEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLK--RGSVD----YINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQI
 |.....       |. |||.... .||  ||.|.   |  |    ||||  ..  . ..|||.||||. .|. .|| ..|..|. ...|| . .|... 
gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkv

KCHLYWPNEmGADKaLKLPHVKLtvelVRLETYQNFVRRWFKLTDLET-QQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLsRDVGPAVVHCS
||. |||.. .... .   ..||    .  ||......| ..... .. .....|.|.. |.|.. |    |.. |  .... .     |  .. |||||
kCqqYWpds.dtka.ygefsikl....lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrk.rgntsivvHCS

AGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
...|||..|| ..  .    . |  .| .|| ..|. ..|..||..|. . .| ... ...
dtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 59-297 6.8e-50 164.6 In-house 42-276 (515) alignment
Range on Protein: 59-297
Range on HMM: 42-276/515.0
TNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadKA
 |   |||... ||| .|. |         ||.||  ..   ... || .|||.  .|  || .|....  .. |..|| |  .|||  |||.  |  ..
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg..ds

LKLPHvkLTVELVRLETYQNFVRRWFKLtdLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRdvGPAVVHCSAGIGRSGTFCLVDCCL
.|. .  . |||| ||.  . ..| ...  |  ..|| | |||.| ||| |.|   ...||....|. .        | ..|||||.|| | .. .| ..
vkfGs..ikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvv

VLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
  . .    .| ...  .|  |. |.|| .|  | |.|. | .
ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_CG7180_pd Subfamily CG7180 31-295 1.3e-49 163.5 In-house 16-288 (296) alignment
Range on Protein: 31-295
Range on HMM: 16-288/296.0
HRFYKEICETCDReAKEKqfSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRA
.  || ....  |  .          |..||. ||. .| |||. |.||..     . |||||  |.    ...|| |..|  .||. || .|..... |
rveyklelkltpr.leig..dCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

VLMLNKLMEKKQiKCHLYWPNEMgadkalKLPHVKLTVELVRLETYQNFVRRWFKLTDL----------ETQQSREVMQFHYTTWPD-FGIPSSPNAFLK
| .| | .. .. ... ||||..      |  . .. ||.|. ..| |.. | ||||            .. . | |..|..|.|.    .|.| ||...
vvvLtktfdfak.mypsywpnks......keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalie

FLQQVRDSGCLS---RDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
....||          . || ||..| | .||| .. .| .| |..| .| .| . .  ||  | .|... ..  . |. . |
lrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 56-297 1.9e-48 160.2 In-house 44-288 (325) alignment
Range on Protein: 56-297
Range on HMM: 44-288/325.0
ERHTNRGLNRYRDVNPYDHSRIVLK----RGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQiKCHLYWPNEMGA
 .  |.  ||...| ..|.||.||.     .| |||||. .. ..    .. .| || .|.. .| .| . ..  |..||.| ..|. .|  |||.||| 
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkd.rcavywpkemgk

DKALKlphvKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRD-SGCL---SRDVGPAVVHCSAGIGRSGTF
 | .      | |.|. .|.. ..| | ... . .  ..| | ||.. .|.|.| .  | ... .|| |   | ..   ..  .| .||||||.||.|.|
sktfG....glevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvf

CLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
  . . |  . .  . .. ...  ||  |  ...|.||  . |.|..| .
islysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 48-297 1.1e-47 157.7 In-house 39-284 (297) alignment
Range on Protein: 48-297
Range on HMM: 39-284/297.0
KQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAerQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQiKCHL
. ...  .|.. |   .||... ||| ||. |.      . ||.||  |.  .   ..| || |  .||  || ||....  ...|||.. |... ||  
niqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcar

YWPNEMGADkalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPS--SPNAFLKFLQQVRDSGCLSRDVgPAVVHCSAGI
||...  .         ...|.|  ..  . |..| ...|  .... | | |.... |||  ..   | ...||....||..     .  | .|||.||.
yWsdkgvtt......fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGv

GRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
|| | .. .| ..  . .  | .. ...  ||  |. |.|| .|  | |.|..| .
Grtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal

0041856 (Phosphotyrosine protein) phosphatases II 60-297 2.8e-47 156.0 In-house 1-171 (182) alignment
Range on Protein: 60-297
Range on HMM: 1-171/182.0
NRGLNRYRDVNPYDHSRivlkrgSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNklmekkqikCHLYWPnemgadkalklph
|. .|||.|. ||||||        |||||||.   .  ...|.||||| .|| .|. |..|.. .....|.         ..||||             
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

vkltvelvrletyqnfvrrwfkltdleTQQSREVMQFHYTTWPDFGIPSsPNAFLKFLQQVRDsgclsrDVGPAVVHCSAGIGRSGTFCLVDCCLVLidk
                           .   |...|..|. |||.|.|. .. .|.|...|..      . || .||||||.||.||... . ...|   
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl...

ygECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
  .... ......||.|.| ..| .|. | ..|. | .
..gvsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 23-296 4.4e-47 155.9 In-house 29-290 (319) alignment
Range on Protein: 23-296
Range on HMM: 29-290/319.0
YKDKGPQWHRFYKEICETCDREAkEKQFstseSERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLM
..|.  . .  .. .|.     | ...|    ..   |.  ||. .. ..|.... |.|       |||||  |.  . . .|| .|||| .|.  || |
fdddltklevefrracklgvnla.dqtf....anldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrm

VWEQKSRAVLMLNklmekkQIKCHLYWPNEMGAdkalKLPHVKLTVELVRlETYQnFVRRWFKLTD-LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFL
.||... ....|       . ||  |||...      |  . |. |..|  || . .| | ..|..  . .. |.. |||.  ||| | | .|  .....
iweyncstivllt......kdkcsqywplkivi....keerfkvkvdsve.etae.yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlv

QQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
..||      ..  . |||||||.||.|..  .|. |  ...    .| ... .||  |  |.|   |  | | |..| 
kkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 60-295 4.6e-47 155.2 In-house 3-237 (237) alignment
Range on Protein: 60-295
Range on HMM: 3-237/237.0
NRGLNRYRDVNPYDHSRIVLKR--GSVDYINANLVQ-LERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNemgADKAlk
|.  ||| ... |||||.|||   ...|||||. .. .. . ..|| .||||  .   || |||..|   ..||  |.|....||| |||.   .|.   
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywps...tdqp..

LPHVKLTVELVRLETYQNFVRRWFKLTDLET-QQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLV
 .. .||| | . | . ..  | . |.   | .. | . |...|.||| |.|    |.|.| ... .      . || ..|||||.||.| | ..|. | 
aaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
   .    .. . .  .   |  .||| ||  | .|.|.|
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 55-296 4.5e-46 152.6 In-house 20-254 (284) alignment
Range on Protein: 55-296
Range on HMM: 20-254/284.0
SERHTNRGLNRYRDVNPYDHSRIVLKRG----SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNklmekkQIKCHLYWPNEMG
..   |.  ||. .. ..|.... |.|       |||||  ..  . . .|| ||||| .|.  || |.||... ....|       . ||  |||... 
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv

AdkalKLPHVKLTVELVRlETyQNFVRRWFKLTD-LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCL
     |  . |. |..|  |. ...| | ..|..  . .. |.. |||.  ||| | | .|  .......||      ..  . |||||||.||.|..  
i....keerfkvkvdsve.es.eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyiv

VDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
.|. |  ...    .| ... .||  |  |.|   |  | | |..| 
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee

0051429 (Phosphotyrosine protein) phosphatases II 85-300 1.9e-42 141.1 In-house 5-228 (272) alignment
Range on Protein: 85-300
Range on HMM: 5-228/272.0
DYINANLVQLERA---ERQYILTQGPLVDTVGHFWLMvWEQKSRAVLMLNKLMEKKQIKCHLYWP------NEMGADKALKLPHVKLTVELVRLETYQNF
.||||. |        .. .....|||  |. .|| . .|.. .....| ...|... ||..|||        .  | |    . .|.| |.  |.. ..
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

VRRWFKLTDL-ETQQSREVMQFHYTTWPDFGIPSSPnaFLKFLQQVRDsgclsrdVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECN--------VS
. | . || |  ....||||..||| |||.|.|...  .|..|....|        || .||||||..|.||..... .|  ...   ..        . 
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

KVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKL
... |||..|.| .|| .|. | |.|..| ...|
eaveelraqrpgavqteeqylflyeallellrsl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 56-295 3.8e-42 139.1 In-house 29-264 (283) alignment
Range on Protein: 56-295
Range on HMM: 29-264/283.0
ERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQL---ERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGAD
  . |.  ||.... |.|  |. ||  | |||||  . .   .. ...|| .|.|| .||  || ||...|  |..|| ||.| ..|||  |||..   |
sadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsed

kalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQS-REVMQFHYTTWPDFGIPSSPNAFLKFlQQVRDSGcLSRDVGPAVVHCSAGIGRSGTFCLVD
      . ..|| | .  | . |... . |    . .|   .  . .  | ..|  .  |...||  .|.         || |||||.||||...|. . 
......yGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkvislq.teskkgPivvhCstgiGrtavfiaas

CCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
. .  .      .| .|.  .|  ||...|| ||  . .....|
asvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 59-294 1.2e-41 137.3 In-house 55-280 (290) alignment
Range on Protein: 59-294
Range on HMM: 55-280/290.0
TNRGLNRYRDVNPYDHSRIVLKRGS-VDYINANLVQLERAerQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadKALKL
|.   |||.||   | .|..|| |   ||. || |.  .|   .|||||.| |||  .| || ..|  |. || .|.|. . ||. |.|.. |  ..| .
tefkknrykdvvcndktrvilkdGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeG..evltf

PHVKLTVELVRlETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSgclsrdVGPAVVHCSAGIGRSGTFCLVDCCLVLI
 .. ..  .   .  .| ... . . | .. ..  .  ..  .|||  .. |  |.|. |. .|         || ||||||||||.|||  .. .| ..
Geitvlcseed.dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqil

DKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAII
 .  | .. ..   ||  |.. .|   |     ....
ldGkeldlldlvralrnsrlnsvqvdiqylalveill

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 32-298 1.8e-41 137.0 In-house 20-280 (439) alignment
Range on Protein: 32-298
Range on HMM: 20-280/439.0
RFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAV
 ..||| |. .    . .  .|   .. ..  |||.|| ..||.|..|.         ||||| ..    .. || ||||  .|. .|| .|.|.|.  .
eifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvti

LMLNKLMEKKQikchlYWPNEMGADkalklpHVKLTVELVRLETYQNFVRRWFKLTDL--ETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVrDSGC
.|| .|.|  .     ||| .  .       .  ..|   |     |.| | ||. .    |.. | |.||||..|||  .|.     |.||. . .|  
vmltnlvesyk.....ywpsdaevc......ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrai.nsan

LSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
 ....|| |||||||.||.||   .| .|  .    . ..  ..  ||  |  ..|.  |  | |.|..| |.
dkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavlediv

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 57-295 2.1e-41 136.7 In-house 4-238 (239) alignment
Range on Protein: 57-295
Range on HMM: 4-238/239.0
RHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANL-VQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGa
.. |.  ||| ..  |||||.||.. |     |||||.   . . . . || ||| .  . | || |.|...   ..||  |.| .. ||| |||.    
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

dKalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGcLsRDVGPAVVHCSAGIGRSGTFCLVD
 |     ...| | | . | . ... | | ....   . | | |.|.| ||| |.|    | | . ...     |     | |.|||||.||.|.| ..|
.k.....ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds.l.pgarpwvihcsagvgrtgaflvid

CCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
. |    |    .. . .  .|  |  ..||..|  | . |..|
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 57-295 2.7e-41 136.3 In-house 5-239 (239) alignment
Range on Protein: 57-295
Range on HMM: 5-239/239.0
RHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANL-VQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGa
.. |.  ||| ..  |||||.||.. |     |||||.   . . . . || ||| .  . | || |.|...   ..||  |.| .. ||| |||.    
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

dKalklpHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGcLsRDVGPAVVHCSAGIGRSGTFCLVD
 |     ...| | | . | . ... | | ....   . | | |.|.| ||| |.|    | | . ...     |     | |.|||||.||.|.| ..|
.k.....ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds.l.pgarpwvihcsagvgrtgaflvid

CCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
. |    |    .. . .  .|  |  ..||..|  | . |..|
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

0046846 (Phosphotyrosine protein) phosphatases II 78-297 2.7e-41 136.6 In-house 6-173 (176) alignment
Range on Protein: 78-297
Range on HMM: 6-173/176.0
VLKRGSVDYINANLVQLERaerqYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKalklphvkltvelvrletyqnfvr
   ....|||||||.   |    .| |||||..|. .|. |..|.. .||..|....|....||. ||| .....                         
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................

rwfkltdletqqsrevmQFHYTTWPDFGIPSSpNAFLKFLQQVRDsgCLSRDvGPAVVHCSAGIGRSGTFCLVDcclvLIDKYGECNVSKVLCELRSYRM
                 |.... |||.|.|.. ...|..|...|.  .|... || .|||||||||.||... .    |. .    .| ..|...|..|.
.................qylhlpwpDhgvpdl.elllellefire..alkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp

-GLIQTADQLDFSYQAIIEGI
 | .|| .|. | |... . .
lgavqtpeQyrflyefellll

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 52-295 3.2e-40 132.7 In-house 32-291 (301) alignment
Range on Protein: 52-295
Range on HMM: 32-291/301.0
TSESERHTNRGLNRYRDVNPYDHSRIVLKRGS------VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYW
.. . ...|. |||......||. ||.||  .       .||||. ..  . ....| .|||.  |.  || ..|..|  ...|. .| |... ||. ||
ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqyw

PNEMGADKALKLPHVKLTVEL-----------VRLETYQN--FVRRWFKLTDLEtqQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGcLSRDVGP
||    ..     .|.|. |            |...   |  .. | || .     .|..|.|.. | ||. |.   |.  |. ...|      . . ||
pnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrq.qkigggp

AVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
 |||||....|||..| |.  |      |  .| .|   .|  ..| ..| .|  . |..| .
vvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm

0043147 (Phosphotyrosine protein) phosphatases II 84-291 4.2e-39 129.4 In-house 5-155 (172) alignment
Range on Protein: 84-291
Range on HMM: 5-155/172.0
VDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLmekkqikchlywpnemgadkalklphvkltvelvrletyqnfvrrwfklT
 |||||... | .  ...| |||||  |. .|| |..|.. .....|..|                                                 .
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................l

DLETQQSREVMQFHYTTWPDFGIPsSPNAFLKFLQQVRDSGCLSRDvGPAVVHCSAGIGRSGTFCLVDCCLvlidkyGECNVSKVLCELRSYRMGLIQTA
 . .. .|...|..|. |||.| | ... .|.||.....  .||.. || .||||||.||.||... . .|        ... ......|. |.| .|. 
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspg.gpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

DQLDFSYQ
.|. | |.
sqyrflyy

0036282 (Phosphotyrosine protein) phosphatases II 85-290 1.3e-38 127.8 In-house 3-163 (174) alignment
Range on Protein: 85-290
Range on HMM: 3-163/174.0
DYINANLVQLERAERQYILTQGPLVdtvghFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNemgadkalklphvkltvelvrletyqnfvrrwfkltd
|||||. . | .  . .|..||||      || |..|.....|.||....|..  ||. |||                                      
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

LETQQSREVMQFHYTTWPDFGIPSSPNaFLKFLQQVRDSGCLsRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDkYGECNVSKVLCELRSYRMGLIQTAD
| .  .|...|..|. |||.| |...  .|.|...|..      . || .||||||.||.||... . .|...   .  .. ... |||..|.| .|| .
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QLDFSY
|. | |
Qyrfly

0049772 (Phosphotyrosine protein) phosphatases II 56-301 2.5e-38 128.0 In-house 42-284 (314) alignment
Range on Protein: 56-301
Range on HMM: 42-284/314.0
ERHTNRGLNRYRDVNPYDhSRIVLKR---GSVDYINANLVQLEraeRQYILTQGPLVDTVGHF----------WLMV--WEQKSRAVLM-----------
    ||  ||| |. |.| .| .|..    ..|||||. |      ...| |||||  ||  |          | ||  .....| . |           
dlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LNKLMEKKQIKCHLYWPNEMgadkalklphvkltvelvrletyqnF-------VrrwfkltdletqqSREVMQFHYTTWPDFGIPsSPNA
          |..|...  . .  ....                                   .             .|........ .||.. | ... 
rLdaAlgKtpllildgngneptaadlellk.........................eelydpelf.............erlgikylripvpDgsap.lled

FLKFLQQVRDSgclsRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIdkygECNVSKVLCELRSYRM-----GLIQTADQLDFSYQAIIEGIKKLH
|..||. ...     .. || .|||.||.||.|||....... |      ... ..| ..|. |.     |.|.. .|. | ..|. | .|.|.
fdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 58-305 3e-37 123.3 In-house 39-285 (307) alignment
Range on Protein: 58-305
Range on HMM: 39-285/307.0
HTNRGLNRYRDVNPYDHSRIVLKRG--SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKAL
..|   |||.||.  |..|||.|    . ||| || . .    ...| .|||| .|. .|| |. ..|  .|.|| |..|  .|||. ||| | |  .. 
santdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvf

KLPHVKLTVELVRLETYQNfVRRWFKLTDLE---TQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRdsgclsRDVGPAVVHCSAGIGRSGTFCLVDC
      ..|. .  ..         ..|.|.   .|.|| . .. .. ||| |.|    . . .|. ||       |  | |||||||.|||||   .  
geapntisvanlgakklap.dedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr......ydtnpvvvhcsaGvGrsGtivaisl

CLVLIDKYGEC-NVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTF
    . .  .| .. |.. |||| |   |||  |  . .. ..|   .|.  |.
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelykety

subfamily_ptpA1_pd Subfamily ptpA1 51-260 8.4e-37 121.9 In-house 38-259 (418) alignment
Range on Protein: 51-260
Range on HMM: 38-259/418.0
STSESERHTNRGLNRYRDVNPYDHSRIVLKR----GSVDYINANLVQLErAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWP
 ||| ... |   ||| .. | .|.|. ||.       |||||| ..     .|.| ||||| .|.  || ||||.. | ..||..  |. .|||  |||
etsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywp

NEMGADKALKLP-----HVKLTVELVRL--ETYQNFVRRWFKLTdLEtQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSG--C-LSR-DVGPAVV
...| ..              .|||| .  .  .. . |  .|| .|  ..|.. |..|  |||. ||   . | ..|. . .       |     | .|
eqiggeqfsiygngnevfgtysvelveviqdpereiitrnirlt.fe.getrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

HCSAGIGRSGTFCLVDCCLVLIDKY
|||||.||.||||     .  .|.|
hcsagvgrtgtfctavimmkkldhy

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 51-297 3.3e-36 119.5 In-house 36-236 (392) alignment
Range on Protein: 51-297
Range on HMM: 36-236/392.0
STSESERHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKqikchlywp
 .. .... |   |||... ||| .|..|         ||.||  ..   .|. || .||| . ..  || ||....  .. |..|| |           
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

nemgadkalklphvkltvelvrletyqnfvrrwfkltdlETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVR-DSGCLSRdvgPAVVHCSAGIGRSG
                                         .. | | |||.| ||| ..|   ...|||...|. | |  ..   | ..|||||.||.|
.......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyth...pliihcsagvgrtg

TFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
    .|. .    |    .| ... ..|  |  ..|| .|  | | |..| .
vvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 59-298 4.9e-36 119.0 In-house 47-288 (305) alignment
Range on Protein: 59-298
Range on HMM: 47-288/305.0
TNRGLNRYRDVNPYDHSRIVLKRG-SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKL
 ..| |||.||   |. |. |.     .|| || |      ...| || || .|   || | ...|  |..|| .|.||   ||. |.. . .    .. 
qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

PHVKLTVELVRLETYQNFVRRWFKL--T----DLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSgclsrdVGPAVVHCSAGIGRSGTFCLVD
   |..| .   .|..       |.  |    .   ...| | ..|.  ||| |.|.. .| |..|.. | |       || ||||||||||.|.  ...
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps......kgpivvhcsagigrtgsvvmle

CCL-VLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
  |  |.      .  |.|  .|  |   ||| .|  | .| |.. ..
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

0049260 (Phosphotyrosine protein) phosphatases II 99-291 1.6e-34 114.2 In-house 9-144 (152) alignment
Range on Protein: 99-291
Range on HMM: 9-144/152.0
RQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWpnemgadkalklphvkltvelvrletyqnfvrrwfkltdletqqsrevmQFHY
...| ||||.  |. .|| |..|.. ....||..|.|.. .||. |.                                                 |...
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qylh

TTWPDFGIPSSPNAFLKFLQQVRDSgcLSRDVGPAVVHCSAGIGRSGTFCLVDCCLvlidkyGECNVSKVLCELRSYRMGLIQTADQLDFSYQ
. |||.| |...  .| .|. ..    . .. || .||||||.||.||... . .|        ... ...  .|. |.| ... .|| | |.
lpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 50-291 9.8e-34 111.4 In-house 46-283 (305) alignment
Range on Protein: 50-291
Range on HMM: 46-283/305.0
FSTSESErHTNRGLNRYRDVNPYDHSRIVLKRGS-VDYINANLVQLER-AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPN
| . .|  . .   |||.||   |.| . |.. | .||| || |      |...| .|||| .|. .|| || ..|   ..|| | .|  ..||  ||| 
fnanqsa.diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpa

EMGADKALKLPHVKLTVELVRL-ETYQNFVRRWFKLTdLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGClsrdvgPAVVHCSAGIGRSGT
 .|  . ||   |   |   .  |   .     ..||    .|.  | ....| ||| |.|    . |..|  .| |        | ||||||||||.||
aqgeklelksgivvenvsgskpmerdaeiqitllnlt.ysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv......pivvhcsagigrtgt

FCLVDCCLVLIDKYGECN-VSKVLCELRSYRMGLIQTADQLDFSYQ
   ..  |  | .  .|  . ...  ||  |   ||.  |  | ..
ivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihr

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 53-292 1.7e-33 110.8 In-house 26-254 (267) alignment
Range on Protein: 53-292
Range on HMM: 26-254/267.0
SESERHTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKkQIkcHLYWPNEMGAD
| |  . |.  ||. |. |||..|..|.    .||||  |.  . ....|.||.||  |...|. .. .||   . .| |  .  .|  .|.|| .||  
sqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd.ni..rlfwPPkmgqa

KALKlphvKLTVELvRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWpdfGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDC
|  .     ||||   ||  .|  .       .. . ...|  ..|  |    | .  . .|| |  .     |     | ||.||.|.||||||  .| 
kkyq....dltveh.slekeendyqiitlelkfknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvids

CLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQA
 |  . . |  .. . | ..|| |.||..| ..  . .. 
qleraktegvsdifdflrkirsqriglvdtkeryiyihel

PTPc_DSPc_SM00012 193-295 9.2e-32 104.8 In-house 2-105 (105) alignment
Range on Protein: 193-295
Range on HMM: 2-105/105.0
VMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKY-GECNVSKVLCELRSYRMGLIQTADQLDFSYQ
|...|||.|||.|.|......|..|..|...   | . .| |||||||.||.|||...|..|  ..|  .| .......|||..|.|..|| .|  | |.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AIIE
|..|
alle

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 58-295 1.6e-31 104.4 In-house 33-268 (285) alignment
Range on Protein: 58-295
Range on HMM: 33-268/285.0
HTNRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLER-AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadKALK
..|  |||| ||   . .|.|||    ||| |. ...    .  || ||||| .|.  || |....|   ||||  |.|    || ||.|...|  . .|
eanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg..evvk

LPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHY--TTWPDFGIPSSPNAFLKFLQQVRDSGClsrDVGPAVVHCSAGIGRSGTFCLVDCCL
. . ..|.  .. |.    .   . ... |   |  .   |     |||   |     .... . |.          | .||||||.||. ||  .| . 
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...kekpicvhcsagvgrtatfvgidyat

VLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
. | .  . ..  .. |.|. |.  .|.  |. | |  ..|
irimenpniemldivremramrfqavqshmqflflyvvlme

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 42-225 2.3e-31 103.8 In-house 17-197 (297) alignment
Range on Protein: 42-225
Range on HMM: 17-197/297.0
DREAKEKQFSTSesERHTNRGLNRYRDVNPYDHSRIVLKRGS--VDYINANLVQL--ERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKK
 .||. ..||..   | .    |||||.  .| .|. |.|.    |||||. | .  | |. .|||.|||| .||  || .|.||  |.. |. || |  
ldeargesfssa..krnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedG

QIKCHLYWPNEMGAdkALKLPHVklTVELVRLETYQnFVRRW-FKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRdSGC
. ||  |||.  .    || ..|   || .   . . | |    .|. .  ..|| |    . .||| |.||  .   .|  ||  | |
rdkcapywpsvvqe..rlkagdv..vveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvc.scc

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 59-286 2.3e-31 103.5 In-house 36-258 (281) alignment
Range on Protein: 59-286
Range on HMM: 36-258/281.0
TNRGLNRYRDVNPYDHSRIVLKR-----GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEmgADK
 |   ||| ..   | ||. ||       | ||| || ..    .| |||||||  .|   || |.|.... |..|| ...| .. ||  |.| .  |  
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn..ahc

ALKLPhvKLTVELVRLETYQNFVRRWFKLTdlETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRdsgclSRDvGPAVVHCSAGIGRSGTFCLVDCC
.|..   ||.|.       . .|   ..|.     ..| . .. .  |||. .| | . .|| |...|     .|   | |.|||||.|||||.  |. .
clqfd..klsvsyedstvnkslvttrlnls..yegetrlithwlwkewpdwqvpessevmlkilrkir.....ars.tppvihcsagvgrsgtlmaveia

LVLID-KYGECNVSKVLCELRS-YRMGLIQTADQL
|  |  ..   .. ...  ||   |   .|| .| 
lqsihshftlpdikqivshlrvtgraasvqtlqqy

0051082 (Phosphotyrosine protein) phosphatases II 84-294 3.3e-31 103.3 In-house 3-150 (151) alignment
Range on Protein: 84-294
Range on HMM: 3-150/151.0
VDYINANLVQLEraerqYILTQGPlvdtVGHFWLMVWEQKSRAVLMLNKLMEKKqiKCHLYWPNEMgadkalklphvkltvelvrletyqnfvrrwfklt
.||||.. |        .....||      .|. ...|.. .....|....| .  .|. |.|..                                   
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

dletqqsREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgclsRDVGPAVVHCSAGIGRSGTFCLVDCCLvlIDkygeCNVSKVLCELRSYRMGLIQTA
       .||...... |||.|.| |..|.|.||....|      . || .||||||.||.||.......|   .    ... ..| |.|..|.|..|. 
.......ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlkrpgvvqpn

DQLDFSYQAII
.|  | ..|..
qqflfqlfall

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 22-287 1.7e-30 100.8 In-house 14-271 (301) alignment
Range on Protein: 22-287
Range on HMM: 14-271/301.0
EYKDKGpQWHRFYKEICETCDREAKEKQFsTSESERHTNRGLNRYRDVnPYDHSR--IVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMV
..||.  .  .||.   |  .  . .|.    ||  . ..  .||  | | . |    |.. |    | || .. .   ...| ||||| .|   || |.
dfkddd.ktakfynttienvnvttidkdh.itesyaylpkdkhryptv.PckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwaml

WEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQ-QSREVMQFHYTTWPDFGIPSSPNAFLKFLQ
   .   . || . .||.. ||. | | ...  . |..   |....   |   .. ..| ....|   . ..| |. . |..|.| |.| |     ....
vqydvekivmlgqkvekleekceeylpvkis..ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlme

QVRDSGclsrdvGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLD
 |..|        | ||||||||||| .|   ..    ..   . .... | .||  |   .||  || 
lvkkse......kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 60-295 4e-29 96.5 In-house 43-269 (288) alignment
Range on Protein: 60-295
Range on HMM: 43-269/288.0
NRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPh
|   .||...   | .|. |.  .  ||.||.|  .. .|. | .| ||  |.. .| |. |.  . ..||..|.|| . |   |.| ..|    ..   
nptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl.

vkltVELVRLETyqNFVRRWFKLTDLETQQSREVMQ----FHYTTWPDFGIPSSPNAFLKFLQQVrdsgclSRDVGPAVVHCSAGIGRSGTFCLVDCCLV
       |. .   . . .  |.. |  ..  |  .     |.  |.| |.| .  ..|..|. .           | |||.|||.||.||. |.   |.
....ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgtlililiale

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE
 .       . ..| .||  |.  |||  |  . .. . |
slrlddflgirsllaklreerfkaiqtemqylyvhrcvle

0044763 (Phosphotyrosine protein) phosphatases II 72-288 1.9e-28 94.7 In-house 2-162 (178) alignment
Range on Protein: 72-288
Range on HMM: 2-162/178.0
YDHSRIVLKR----GSVDYINANLVQleraERqYILTQGPLvdtvGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGadkalklphvkltvelv
.|..| .|       ..|||||. .     .. ..|.. |      ... ...|.. .....|.. .|  ..||. ||| |.|                 
ldrtrvllsnleglersdyinaseil....pg.lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................

rletyqnfvrrwfkltdletqqsrevMQFHYTTWPDFGIPSSPNAFLKFLQQVRD----SGclsrdvGPAVVHCSAGIGRSGTFCLVDCCLVLidkygEC
                          .|.... .||.| |...  ||.|.. ...    .|      || .||||||.|||||... . ...|      .
..........................iqylhipipDhgvpdllehflefvefieealdekg......gpvlVHCsaGvgRsgtlvaaylmkkl.....gl

NVSKVLCELRSYRMgLIQTADQLDF
.. ... ..|..|.  ... .|| .
sleeaielvrerRp.ivpnpgqlrq

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 61-296 3.7e-27 89.8 In-house 44-275 (312) alignment
Range on Protein: 61-296
Range on HMM: 44-275/312.0
RGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKaLKLpHV
. |||| ... .|  |. |      || ||.|..     ... ||||| .|. ||| ..    | ....|  ..|    ||  |  . .|  . |.  | 
kdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd.led.hr

KLTVELV----RLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRdsgclsRDVGPAVVHCSAGIGRSGTFCLVDCCLVL
  |           . ..   | .|.    | |   . .. ...||| |.| | .. |..|  |.      .|  | . |||||.||.||..|..  .  
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk......kdkkpviahcsagvgrtgtlaliesmiaa

IDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG
. .    || ...  ||  |   ...  |  .. ....| 
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

0048076 (Phosphotyrosine protein) phosphatases II 173-293 1.5e-25 85.0 In-house 27-139 (145) alignment
Range on Protein: 173-293
Range on HMM: 27-139/145.0
QNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDsgCLSRDvGPAVVHCSAGIGRSGTFClvdcCLVLIDKYGeCNVSKVLCEL
.. ..... ||. ..  .|...|..|. |||.|.|.... .|.||.....  .|... || .||||||.||.||..    .. |. ..| ... ..| ..
dlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefiee..alkeg.gpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelv

RSYRMGLIQTADQLDFSYQAI
||.|.| ... .|| | |...
rsqrpgavpnpgqlrflyefe

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 59-297 3.7e-24 79.9 In-house 46-279 (303) alignment
Range on Protein: 59-297
Range on HMM: 46-279/303.0
TNRGLNRYRDVNPYDHSRIVLKRGSvdYINANLVQLERaERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEmgaDKALKLP
.|   ||. ||   |||.. |   |  || |. ..|.  ... |||| ||  |   || |. ||| . ||.|    | ...  .  .|..   .  ||. 
knmdknrfvdvicldhskvklsdss..yihasylelds.skkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn...qdflkfe

HVKLTV-ELVRLETYQNFVRRWFKLTDLETQQsrEVMQFHYTTWPDFGIPSS-PNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCC-LV
.  . | |. |.|  . .| .   ... . .    .   || .||   |||     |.| . |..       |  |.|    .| ||.|||.| . . | 
ersirvgefkrvelgdgwvlkvlsvsngdyks..flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahls

LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI
| ..    .. |.|  .|  |.  .|   |. . |  . | .
lhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 61-285 7.2e-24 78.9 In-house 53-278 (310) alignment
Range on Protein: 61-285
Range on HMM: 53-278/310.0
RGLNRYRDVNPYDHSRIVLK---RGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNeMGADKAL--
   ||| ||   | ||. ||       ||| || |. .     .| .||||  |.  || |...... ..|.| | .|. . ||  |||  .|  ..   
mhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtetygc

----KLPHVKLTVELVRLEtyQNFVRRWFKLTDLETQ-QSREVMQFHYTTWPDFGIPSSPN--AFLKFLQQVRDsgclsrdvGPAVVHCSAGIGRSGTFC
    .|       |.. |     ||     . .  .. .   |   ..  ||| |.|         ..| |||         || |||||||..| .. .
irvtnlsesseefeicnla..vtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh........gpcvvhcsagkdrlyvvv

LVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQ
 ..  .  .|.  . .. .|  ||.  |.  |||  |
alklkidkldrglkvdaeevktellksraiciqtelq

subfamily_CG42327_pd Subfamily CG42327 63-223 3.1e-23 76.9 In-house 31-193 (319) alignment
Range on Protein: 63-223
Range on HMM: 31-193/319.0
LNRYRDVNPYDHSRIVLKRG----SVDYINANLVQL-ERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKL
 .|. .| |  ..|.||.|     .  |..|. |.  . |. .|| .| .| |.   || .||||.|| .. | .| |.   .|  |.| . . |     
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

PHVKLTveLVRLETYQNFVRRWFKLTDLETQQSREVMQFHYtTWPDFGIPSSPNAFLKFLQQVRDS
 ....|  |   |. ....   . |  .. ..|||.  . |  |.. ..|....|..  | .||.|
Gdilvt..lkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

0048179 (Phosphotyrosine protein) phosphatases II 183-288 8.1e-23 76.2 In-house 48-136 (144) alignment
Range on Protein: 183-288
Range on HMM: 48-136/144.0
TdletqqsreVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSgcLSRDvGPAVVHCSAGIGRSGTFCLVDCCLvlidKYGeCNVSKVLCELRSYRMGLIQT
.         ..|.... |||.|.|.... .|.||. ...   |... || .||||||.||.||... . ..    |.| ... ..| ..||.|.| ...
e.........giqylhlpwpDhgvpdllellleflefieea..leeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpn

ADQLDF
 .|| |
pgqlrf

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 81-310 6.3e-21 69.8 In-house 43-272 (290) alignment
Range on Protein: 81-310
Range on HMM: 43-272/290.0
RGSVDYINANLVQLERaERQYILTQGPLVDT-------VGHFWLMVWEQKSRAVLMLNKLMEKKQI----KCHLYWPNEMGadKALKLPHVklTVELVRL
| . ||| || |.      . |||| |. ..       . .|| |. . |.. | || . .||..      |  | |...|  . ||.  .  ||.    
rfnddyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg..eelkfkgl..tvkCksk

ETYQNFVRRWFKLTdLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGClsrdvgPAVVHCSAGIGRSGTFCLVDCCL-VLIDKYGECNVSKV
|. ... .|   ..  . ..   |    .  | .  .. ..  .|. .|.|. |.       |..|||  || || ..  ..     .... |. .. .|
ekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt......pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledv

LCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEE
| .||. |  .|..| .| |   .|.  ...  |... ...|
lkalrkqralaitsalelafvdagivllaievldqfaeeete

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 100-295 2.7e-20 67.5 In-house 36-219 (255) alignment
Range on Protein: 100-295
Range on HMM: 36-219/255.0
QYILtqgplvdTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMgaDKALKLPHVKLTVELvrleTYQNFVRRWFKLTDLE--TQQSREVMQFH
 |.|       || .|. ..  .|.  | ||  . |... ||. |.| |   |. ||| .|..|.      . .. | |  ..|      .. ..|  ..
lysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplek..deklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhys

YTTWPDFGIPSSPNAFLKFLQQVRDSgclsRDVgpaVVHCSAGIGRSGTFCLVDCCLV----LID--KYGECNVSKVLCELRSYRMGLIQTADQLDFSYQ
|. |..   |  ..  |. |. ||||    . |   |||||.||||| .| |..         .|  . .| .  ..| |||| | . |.|  || ||  
ykGWieknaPelareilnilkvvrds....ksv...vvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsil

AIIE
 ...
mvld

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 63-158 8.4e-20 65.8 In-house 50-163 (350) alignment
Range on Protein: 63-158
Range on HMM: 50-163/350.0
LNRYRDVNPYDHSRIVLKR------------GSVDYINANLVQLER------AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLY
 |||... ||.|||. ||.             . |||||| ..|.|      .. .|| ||.||  ||  |. .. . | . .|.|....|    ||. |
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPNEMGADKALKLP
|..    |. .|| 
Wqegsydditvkla

subfamily_hpo-7_pd Subfamily hpo-7 99-294 2.4e-19 64.2 In-house 38-224 (263) alignment
Range on Protein: 99-294
Range on HMM: 38-224/263.0
RQYILtqgpLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMgaDKALKLPHVKLTVELVRLetyqNFVRRWFKLTD-LE-TQQSREVMQF
  |.|    ||.|.  |. ..  .|.  | ||    |. . ||  |.| |   |. .|| .|....  |      . . .  .|.  |.  .. ..| ..
nlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlek..dekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhy

HYTTWPDFGIPSSPNAFLKFLQQVRDSgclsRDVgpaVVHCSAGIGRSGTFCLVDCCLV----LID--KYGECNVSKVLCELRSYRMGLIQTADQLDFSY
 |. |..   |  ..  |. |. .|.|    ...   |||||.|||||  | ...         .|  . .| .  ..| |||| | . |.|  || || 
sykgWiekndpelareilnilkvarns....ksl...vvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi

QAII
  ..
lmvL

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 60-299 1.7e-18 61.0 In-house 51-287 (302) alignment
Range on Protein: 60-299
Range on HMM: 51-287/302.0
NRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTV---GHFWLMVWEQKSRAVLMLNKLMEKKQiKCHLYWPNEMGADKALK
|   |.  ||. .|. .. |.    .|.||  |..   .|. ||.| | ||..    .|| ||...|   | .| .  | |.   . ..|...|. |  .
nlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeyg

lphvKLTVELVRLETYQNFVrRWFKLTDLETQQSREVMQ--FHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDvgPAVVHCSAGIGRSGTFCLVDCCL
    |. |   . |  .. .   . .  |    |  |.    . | |..  .| . ..  |  ..| ..   . .  ..|.    |.|| |.|  .   .
....kmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikade..ntvivSknGaGRagafltlavav

VLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
  ..|  | |.. ..  .|| |   .....|  . | |..  |||
eklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 81-299 1.8e-18 61.1 In-house 58-290 (302) alignment
Range on Protein: 81-299
Range on HMM: 58-290/302.0
RGSVDYINANLVQLERAerQYILTQG-----------------PLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADkaLKLPHVKLT
  . |.||||...|..   ..|..||                 |  .|.  .| .. . .   |  | ...|... ||  |. ...|    ||. .  ..
dfkndfinanvlkldei..kwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvgge..lkfgrytvk

VELVRLETYQNFVRRWFKLTDLETQQSR-------EVMQFHYTTWPDFGIPSSPNAFLKFLQQvrdSGCLSRDVgpaVVHCSAGIGRSGTFCLVDCCLVL
   |. .  .   .. |||  .| . ..        |  .....||| | |  ... |. |.      .  ..|   .||||||.||.||.  .   . |
tvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkf...cesykknv...lvhcsaGvGrtGtlvaikyGiql

IDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK
  |   ... .... .|. | | .|...|| .    .  |. .
cskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme

subfamily_eak_pd Subfamily eak 28-226 1e-17 58.5 In-house 20-213 (332) alignment
Range on Protein: 28-226
Range on HMM: 20-213/332.0
PQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNrYRDVNPYDHSRIVLK---RGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKS
  | |  . |    | . ...  | ||..|  .   |   .. |||.  . |    .    |||| |...    |.||||  .  | |  || || ||||
hiwnrinqrinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqks

RAVLMLNKLMEKKQIKCHLYWPNEmgADKALKLPHVKLTVELVrlETYQNFVRRWFKLTDleTQQSREVMQFHYTTWPDFGIPSSpNAFLKFLQQVRDSG
 |...| . .|.|  |   |.|..  . . ||  .....         ...  | ..|.     .. .|. ...  | .. .|   . || . . ... |
paivqlledvelkleksdkyfpdk..treelkfGildverkef..vkrniletrllelsk..GnethrvlhykvfGwtettlpky.edflalrkvmkevG

CL
 |
vl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 185-298 1.4e-17 58.2 In-house 83-195 (440) alignment
Range on Protein: 185-298
Range on HMM: 83-195/440.0
LETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSrDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTAD
..  .|| . |.||  ||| |.|      ||..|.| .|   .   || .|||||| ||.|    ||. |    .  . ..  ..  .|. |  ..|| .
ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpe

QLDFSYQAIIEGIK
|  | ..|..||. 
qyafvheavlegll

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 97-291 1.5e-17 58.5 In-house 3-198 (199) alignment
Range on Protein: 97-291
Range on HMM: 3-198/199.0
AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNE-MGADkalKLPHVKLTVELvrLETYQNFVRRWFKLTDLET--QQSREV
..|.|| || || .|.  || ||||  |  ..|.|    .|.    .|||    |.    |   . .|..   . |  ...   . ||.  |    .||.
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtg...kygslsvttkt..ittkpdytitaliltnnttappstrei

MQFHYTTWPDFGIPSSpNAFLKFLQQVRDSGCL--SRDVGPAVVHCSAGIGRSGTFCLVDCCLVLID--KYGECNVSKVLCELRSYRMGLIQTADQLDFS
 .. .|.| .   |     |. |.   |.           | .|||| | | .| |  .|  .   .  |    .. .|   ||  | |.| . .. .| 
shyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

YQ
||
yq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 97-291 1.8e-17 58.2 In-house 2-197 (198) alignment
Range on Protein: 97-291
Range on HMM: 2-197/198.0
AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNE-MGADkalKLPHVKLTVELvrLETYQNFVRRWFKLTDLET--QQSREV
..|.|| || || .|.  || ||||  |  ..|.|    .|.    .|||    |.    |   . .|..   . |  ...   . ||.  |    .||.
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtg...kygslsvttkt..ittkpdytitaliltnnttappstrei

MQFHYTTWPDFGIPSSpNAFLKFLQQVRDSGCL--SRDVGPAVVHCSAGIGRSGTFCLVDCCLVLID--KYGECNVSKVLCELRSYRMGLIQTADQLDFS
 .. .|.| .   |     |. |.   |.           | .|||| | | .| |  .|  .   .  |    .. .|   ||  | |.| . .. .| 
shyqftswkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

YQ
||
yq

subfamily_egg_pd Subfamily egg 43-255 2e-17 57.9 In-house 25-226 (307) alignment
Range on Protein: 43-255
Range on HMM: 25-226/307.0
REAKEKQFSTSESERHTNRglNRYRDVNPYDHSRIVL--KRG--SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKkq
  ..|. . |. |. . ..   | . |.  | ||. |  .||  . |.| || |. .    ..||.| || .||  || ||.... . ..||.   |   
esvdeislttaasdnnlek..arskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..

IKCHLYWPNEMgADKALKLPhVKLTVELVRLETYQNfvrRWFKLTDLETQQS-REVMQFHYTTWpDFGIPSSPNAFLKFLQQVRDsgcLSRdvgPAVVHC
 .|. |||.   .| .  .|   | .| ....   .     |..| |    . .| .   .  . |.   |     |. |...|.   ||.   |.||..
erceyywpkae.sdslvtvp.Gslrienlkvdskad...plfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrn...lsk...pvvvqd

SAGIGRSGTFCLVDCCLV
  |. ...|.  ..  |.
ilGvskaatlvaieiall

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 192-293 3.6e-11 37.4 In-house 216-340 (350) alignment
Range on Protein: 192-293
Range on HMM: 216-340/350.0
EVMQFHYTTWPDFGIPSSPNAFLKFLQ---QVRD-----SGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLV-------LIDKYGEC--------NVSKV
.|.|...  |.| ..   |. .|. |.   .. |     |   .    | .||||||.|| ||.. .|  |        | ... .          .| .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

LCELRSYRMGLIQTADQLDFSYQAI
. |||. |. ..|. ||  | |.|.
vnelrkqrismvqnldqfifiYeal

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 61-203 9.4e-11 35.8 In-house 97-232 (244) alignment
Range on Protein: 61-203
Range on HMM: 97-232/244.0
RGLNRYRDVNPYDHSRIVLKRGSV--DYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQikchlYWPNEmgadKALKLP
   ||     |.| .|. | .||.   |||| .|       .||||| || ||   || |. |..   ...|  . |. .     |||.     . |.  
swknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpds....eplewy

HVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPD
   .|| |   . ..|     ...     .  . .  |  . || 
eeditvtltdrdefknikasnleiesdmneshqaltmfqisnwps

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 232-298 1.4e-10 35.6 In-house 230-296 (297) alignment
Range on Protein: 232-298
Range on HMM: 230-296/297.0
PAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
. .||||||.||||   | |  |  . |    .|  .|  ||. |  |.|| .| .. |.|... .|
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkklk

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 85-158 1.6e-10 34.9 In-house 91-166 (349) alignment
Range on Protein: 85-158
Range on HMM: 91-166/349.0
DYINANLVQLER--AERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLP
|||||| ..| |  .|..|| || ||  ||  |. ..  .. . || ||.  |.   ||. || .   ... .|| 
dyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklq

0038934 (Phosphotyrosine protein) phosphatases II 192-292 1.5e-09 33.3 In-house 78-172 (194) alignment
Range on Protein: 192-292
Range on HMM: 78-172/194.0
EVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDvGPAVVHCSAGIGRSGTFClvdcCLVLIDKYGEcNVSKVLCELRSYRMGLIQTADQLDFSYQ
  ....   .||.| . | .  |.||. | .    . . |  .||| ||.||.||..    .  || ..|  .. . .  .|. | | |.. |.|.  ..
agieylklpfpddgtvPsleillrfldlvdeflnedpg.gvvaVHCkaGlgRtGtlv....aaYLiyrlgm.saeeAialfrekRpgaipnqdyleallk

A
 
r

subfamily_CG42327_pd Subfamily CG42327 229-298 1.5e-08 28.7 In-house 246-316 (319) alignment
Range on Protein: 229-298
Range on HMM: 246-316/319.0
DVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKY-GECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK
. || ||||| |.||.|.    |  .  ...     .. ...  .|  |   ..| .| .| |. . |  |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 53-130 1.8e-08 28.3 In-house 32-116 (347) alignment
Range on Protein: 53-130
Range on HMM: 32-116/347.0
SESERHTNRglNRYRDVNPYDHSRIVLK-----RGSV----DYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLML
.| |.  ..  || .||.  | .|.||       .       ||||  .... |...||||| || |||  || ||   |   |. .
vewekslsk..nrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 188-258 4.8e-08 26.7 In-house 215-293 (349) alignment
Range on Protein: 188-258
Range on HMM: 215-293/349.0
QQSREVMQFHYTTWPDFGIPSSPNAFLKFLQqVR----DS----GCL-SRDVGPAVVHCSAGIGRSGTFCLVDCCLVLID
..  |..|. .  |.| ..   | ..|. |. |.    |.      | . .. . .|||||| ||.|... .|  | .. 
ekPyellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsile

subfamily_PTPDC1_pd Subfamily PTPDC1 186-288 5.4e-08 27.5 In-house 76-167 (182) alignment
Range on Protein: 186-288
Range on HMM: 76-167/182.0
ETQQSREVMqFHYTTWPDFGIPSsPNAFLKFLqQVRDSGCLSRdvgPAVVHCSAGIGRSGTfcLVDCCLVLIDKYGecnVSKVLCELRSYRMGLIQTADQ
|  . .... ..  .|.|.| .|  .  |    .| .. .         ||| || || |   |. | ||  ...     .| .  .|| |   ||| .|
ealmeqgiy.vynfgwkDygvas.leriLdiv.kvvafalqeg...kvavhChaGlGrtGv..liacylvyakrlt...aekaiklvrskrpksiqtreq

LDF
...
vel

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 59-142 6e-08 26.5 In-house 33-119 (332) alignment
Range on Protein: 59-142
Range on HMM: 33-119/332.0
TNRGLNRYRDVNPYDHSRIVL--KRGSVDYINANLVQLERAERQYILTQGPLVDTVG-HFWLMVWEQKSRAVLMLNKLMEKKQIKCH
 |  .||   .  .||||. |  . |  |. ||. |.    .  ||..| |. |     || || |.|   .|..  . ||.. |. 
nnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkap

PTEN_1 183-286 1.2e-07 26.7 In-house 75-182 (196) alignment
Range on Protein: 183-286
Range on HMM: 75-182/196.0
TD---------LETQQSREVMQFHYTTWPDFGIPSSpNAFLKFLQQVrDSGCLSRD-VGPAVVHCSAGIGRSGTFClvdcCLVLIDKYGeCNVSKVLCEL
..          ...  .. ....   ..|.| ||  . ..... .. .. .||..  . ..||| ||.||||| .    .  |. |..  .. . |  .
seeeelsgrsydleeffksgveylhfpieDhgapsl.selfdicksf.iewllsdpngnvVlVHCkaGlgRsGtvv....aayLmykgk.ltadeAlelv

RSYR-MGLIQTADQL
|. |  | .... | 
rekRppgapnspsqe

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 71-175 2.2e-07 25.3 In-house 4-95 (130) alignment
Range on Protein: 71-175
Range on HMM: 4-95/130.0
PYDHSRIVlkrgSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQikchlYWPNEmgadKALKLPHVKLTVELVRLE
... ||.       .||||..| |    ..|.||| || ||  .|| |. |.    ...|  . |. .     |||.     . |.    ...| |   .
efevsrlq....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpds....ePlewyeediivtltdrd

TYQNF
 ..| 
efkni

subfamily_eak_pd Subfamily eak 234-315 3.2e-07 24.0 In-house 240-322 (332) alignment
Range on Protein: 234-315
Range on HMM: 240-322/332.0
VVHCSAGIGRSGTFCLVDCCLVLIDKYG--ECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHdPTFLDAEEPLISN
.. .. |  |.|.| ..|  . |||.       | ...   .| |.  . .| |  | |..... ... . . . | ...|.. 
iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn.nrlrdlkkyleay

subfamily_DSP23_pd Subfamily DSP23 194-288 1.3e-06 23.1 In-house 52-137 (148) alignment
Range on Protein: 194-288
Range on HMM: 52-137/148.0
MQFHYTTWPDFgIPSSPNAFLKFLQQVRDSGCLSRDVGpavVHCSAGIGRSGTfcLVDCCLVLIDKygeCNVSKVLCELRSYRMGLIQTADQLDF
. ..    .|.  | ...   .|.. | ..   .  |.   |||  | ||.||  .. | ||   |      .. . |.|  | | ..| .| . 
ltlvrlriddy.hppaleqvvefvrvveeaeekneavs...vhcllgrgrtgt..mlacylvkerk...laaaeaiaevrrlrpgsvetveqekl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 100-147 2.6e-06 21.0 In-house 237-281 (440) alignment
Range on Protein: 100-147
Range on HMM: 237-281/440.0
QYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKkqiKCHLYWPN
 .| || ||  ||  || .| . .  ...|||.| .|    | .||| 
afiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv

subfamily_CDKN3_pd Subfamily CDKN3 194-288 4.9e-06 20.2 In-house 100-187 (202) alignment
Range on Protein: 194-288
Range on HMM: 100-187/202.0
MQFHYTTWPDFGIPSSPNaFLKFLQQVRDsgCLSRDVGpAVVHCSAGIGRSgtfCLVDCCLVL-IDKYgeCNVSKVLCELRSYR-MGLIQTADQLDF
.  |.   .| ..|.  .  ||.|...|   .|    . ..|||  |.|||   .||  ||.| .| .   .  . . .||  .  . |||  | ..
livhhypiadglvpdias.clkileelri..nlkayrk.tlvhcygglgrs...slviaclllylddt..iepkdaidklrdlkgsraiqtvkqyny

PTPc_motif_SM00404 211-250 9.8e-06 20.5 In-house 67-100 (140) alignment
Range on Protein: 211-250
Range on HMM: 67-100/140.0
NAFLKFLQQVrdsgclSRDVGPAVVHCSAGIGRSGTFCLV
.. |.|....       .. |  .||| ||. ||.|....
dkvldfiena......ekkggkvlVHCqaGvSRSatliia