Gene Pez in Drosophila melanogaster

Synonym: CG9493, Dmel\CG9493, PTPD1, dPez, Dmel_CG9493, Pez

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN14
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP041_AA protein Get Run
DmelP041_AA_965-1247 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN14_pd Subfamily PTPN14 961-1250 1.7e-135 445.8 In-house 3-300 (300) alignment 
Range on Protein: 961-1250
Range on HMM: 3-300/300.0
ISGRYSKDKLCQILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATVGTKQRFYIVAQSPQ
...|..|||...||..||.....|.|.|||||.||.||...| |.||..||.....|||.||||.|.|...|..||.|||||...||.|.|.|||||.|.
eatratkdkrakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl

ePLTMRIFWQCVWEADVYLVVQLTED--------MSYIPRN--SHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRD
 .||...|||.|||..|.|.|.|||.        ..|.|..  .....|||.|.|...||...|...|..|.|.|.||...|.||.|||.||.....|.|
.eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeD

VNHFLDFLEELNSVRLASTQEVPPgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTR
|..||..|||..||| ....||.. ....||||.||..|.||.||....|||..||.|||..||..|...||.||......||||||.|..||.|||..|
vkgflsyLeevqsvrrktnseves.keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylknsr
0050432 (Phosphotyrosine protein) phosphatases II 960-1248 5.1e-62 205.3 In-house 21-301 (308) alignment 
Range on Protein: 960-1248
Range on HMM: 21-301/308.0
PISGRYSKDKLCQILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLtpcrDNRHGYVNASSISATVGTKQRFYIVAQSP
..| ..| ..|...|...|. ..|..|||....  ..  |..|||.|| .||  ...|||| .||.|    |. ..|.||| ..  .  ..| .|..|.|
vsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgP

QEPlTMRIFWQCVWEADVYLVVQLTEDMS--------YIPRNSH-QRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRD
 .  |.  ||. ||| .| ..| ||. .         | | . . . ||.|.|.|.    .. | .|. .|.| .. .  .| |. ..| .| ....| .
lpn.tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps

VNHFLDFLEELNSVRlastqevppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
....|||||......             ..|.. ||  | ||.|. ...||||  |...  .|.. .. .||.||   .... ||.|.| .|. |||.
peilldflelvrksl............pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0036941 (Phosphotyrosine protein) phosphatases II 972-1250 1.6e-60 200.3 In-house 4-281 (297) alignment 
Range on Protein: 972-1250
Range on HMM: 4-281/297.0
QILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLtpcRDNRHGYVNASSIsaTVGTKQRFYIVAQSPQEPlTMRIFWQC
..|...|. ..|  |||.....     ...|||.|| .||. ...||||..||.|    |. ..|.||| .  ..   .| .|..| |..  |.  ||..
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv..dgydlkrkfIatqgPlpn.tvedFWrm

VWEADVYLVVQLTEDMS--------YIPRNSHQRLEFGQFQVYQEFSQT--TDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEEL
||| .|  .| |||...        | | .  . |..|.|.|     ..   | .|. .|..... .   | |....| .| . ..| .....|||.|..
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

NSVRLAStqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLD---HNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTR
..|. ..        . ..||| ||  | ||||. ..|||.|. |.   ... .||. .. .||.||  ....| ||.|.| .|. .||...
rkvlkll........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0040438 (Phosphotyrosine protein) phosphatases II 977-1249 4.1e-57 189.2 In-house 15-279 (317) alignment 
Range on Protein: 977-1249
Range on HMM: 15-279/317.0
KLSdSQLFMEFERIPKRREHaLYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSIsaTVGTKQRFYIVAQSPQePLTMRIFWQCVWEA
.    .|  |||....   .  |..|.|.|| .||. |..||||..||.|.|.   . ..|.||| .  ..  ..| .|..|.|. | |.  ||..||| 
sdf.talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrkfIatqgPl.pntvedFwrmvweq

DVYLVVQLTEDM--------SYIPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRla
.| ..| ||| .         | |    . |..|.|.|     .. . .|  .|....  .   | |. ..| .| ....| . ...|||||......  
gvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal..

stqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRT
         . . ||| ||  | ||.|. ..|.|.|. |......|.. .. .||.||  ......||.|.| .|. ||||.
........edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0051299 (Phosphotyrosine protein) phosphatases II 980-1247 5.5e-57 188.8 In-house 22-287 (288) alignment 
Range on Protein: 980-1247
Range on HMM: 22-287/288.0
DSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSIsaTVGTKQRFYIVAQSPQEPlTMRIFWQCVWEADVY
 ..|..|||....  ..  . .|||.|| .||  ...||||..||.|..  . . ..|.||| |  ..  ..| .|..| | .  |.  ||. ||| .| 
ltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi..dgynlkrkfIatqgPlpn.tvedFWrmvweqnvr

LVVQLTEDM--------SYIPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHV----PSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRL
..| ||. .         | |   .. |..|...|.    .. | .|. .|.. ..    ..  .| |. ..| .| ....| .....||||....... 
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

astqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
          ....||. ||  | ||.|. ...||||. |.... .|..... .||.||  ..... ||.|.| .|. |||
..........sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
0047943 (Phosphotyrosine protein) phosphatases II 972-1246 7.3e-57 188.3 In-house 3-272 (273) alignment 
Range on Protein: 972-1246
Range on HMM: 3-272/273.0
QILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLtpcRDNRHGYVNASSIsaTVGTKQRFYIVAQSPQEPlTMRIFWQC
..|...|. ..|..|||....  ..  |..|||.||  ||  ...||||..||.|    |. ..|.||| .  ..  ..| .|..| | .  |.  ||..
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyv..dgynlkrkfiatqgPlpn.tvedfwrm

VWEADVYLVVQLTEDMS--------YIPRNSHQ-RLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELN
||| .| ..| |||...        | | .  .  |..|.|.|.    .| | .|. .|.|... .  .| |....| .| ....| .....|.|.|...
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

SVRLASTQEvppghntnPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
... |. ..        .||. ||  | ||.|. ...||||. | ..  .|.. .. .|| ||  ..... ||.|.|..|. ||
kalealpsn........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 983-1249 3.8e-55 182.6 In-house 2-277 (284) alignment 
Range on Protein: 983-1249
Range on HMM: 2-277/284.0
LFMEFERIPKRREHA--LYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD--NRHGYVNASSISATVG---TKQRFYIVAQSPQEPlTMRIFWQCVWEA
|. |||....   .    ...|||.||  ||  ...||||..||.|... .  . ..|.||| ..        ... .|..| | .  |.  ||..||| 
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.tvedFwrmvweq

DVYLVVQLTEDMS--------YIPRNsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVP-SRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRL
.| ..| ||| ..        | | . .. |..|.|.|.    .. | .|...|.| ..  .  .| |....| .| ....| .....|.||....... 
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

AstqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNE---DLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRT
.        .....|.. ||  | ||.|. ...||||. |....    .|.. .. .|| ||   . .|.||.|.|..|. |||..
n........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0039614 (Phosphotyrosine protein) phosphatases II 967-1249 1.8e-54 180.6 In-house 18-292 (297) alignment 
Range on Protein: 967-1249
Range on HMM: 18-292/297.0
KDKLCQILDQKLSDSQLFMEFERIPKRREHalYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD--NRHGYVNASSIsaTVGTK-QRFYIVAQSPQEPl
   |.. |....| ..|..|||....  .   |..|||.|| .||  ...||||..||.|.|...  . . |.||| .  ..  . .| .|..| |..  
vldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlpe.

TMRIFWQCVWEADVYLVVQLTEDM-------SYIPRNSHqrlEFGQFQVYQEFSQTTDRCTTIKLRLYHvpSRRYRSVWYLQYADWAEQNCPRDVNHFLD
|.  ||. ||| .|  .| ||. .       .| | ..    ..|.|.|.    .. | .|. .|.. .  .   | |. .|| .| . ..| .....|.
tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellle

FLEELNSVRLAStqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRT
|||...... ..        . . ||| ||  | ||.|. ..|.|.|. |... ..|.. .. .|| ||  ..... ||.|.|..|. .|||.
flelvrealael........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0045450 (Phosphotyrosine protein) phosphatases II 980-1247 9.8e-54 178.5 In-house 26-305 (307) alignment 
Range on Protein: 980-1247
Range on HMM: 26-305/307.0
DSQLFMEFERIPKRRE--HALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD--NRHGYVNASSISA------TVGTKQRFYIVAQSPQEPlTMRIFW
 . |. |||....        |..|||.|| .||  ...||||..||.|... .  . ..|.||| .         .  ..| .|..|.|..  |.  ||
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe.tvedFw

QCVWEADVYLVVQLTEDM--------SYIPRNsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHV-PSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEE
. .|| .| ..| |||..         | | .  . |..|.|.|.    .. | .|  .|.. .  ..   | |....| .| ....| .....|||.||
rmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

LNSVRLAstqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNED---LDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
..... .        .. . ||| ||  | ||.|. ..|.|.|. |....    .|.. .. .|| ||  ..... ||.|.|..|. .|.
vrkalee........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0043336 (Phosphotyrosine protein) phosphatases II 979-1246 1.2e-51 171.2 In-house 18-277 (278) alignment 
Range on Protein: 979-1246
Range on HMM: 18-277/278.0
SDSQLFMEFERIPKRREhALYECALLEENEPKNHDPNFLPYDDNRVRLTPCR-DNRHGYVNASSIsaTVGTKQRFYIVAQSPQEPlTMRIFWQCVWEADV
. . |  |||....      |..|||.|| .||  ...|||| .||.|...  |. ..|.||| .  ..  ..| .|..| |..  |.  ||. ||| .|
lktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpe.tvedFwrmvwelgv

YLVVQLTEDM--------SYIPrnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlast
  .| |||..         | |    . |..|.|.|.    .. | .|...|.. .  .  .| |. ..| .| ....| .....||||.......    
ttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal....

qevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
      .. | ||| ||  | ||.|. ....|||. |...  .|.. .. .||.|| ...... ||.|.|..|. ||
......edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0045098 (Phosphotyrosine protein) phosphatases II 977-1248 6.2e-51 168.8 In-house 3-274 (278) alignment 
Range on Protein: 977-1248
Range on HMM: 3-274/278.0
KLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRltpcrdnrhGYVNASSISATvgtkQRFYIVAQSPQEPlTMRIFWQCVWEAD
.|....|..|||...       ...||...| .||  ...|||| .||.         .|.||| |.      .. .|..| | .  |.  ||...|| .
alasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy....pkkfIatqgPlps.tvadfwrmlwelg

VYLVVQLTED--------MSYIPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHV----PSRRYRSVWYLQYADWAEQNCPRDV--NHFLDFLEELN
.  .| |||           | |   .. |..|.|.|. .  ...|  |...|.....    ..   | |..|.|  | . ..| .   ..||..||...
itvivmltelvelgrekcaqywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefir

SVRLASTQEVPPGHN---TNPPVLLHCLEGGGRSGVTLTADLLLYTLdhNEDLDIPRVIGQLRHQRDS-IIPSLAQYKFIYNLLITYLKR
... .  . .   ..    . ||| ||  | ||.|.   |.|.|. |  .. .|.. .. .|| ||   ....| ||.|.| .|. .|.|
ealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
Y_phosphatase Protein-tyrosine phosphatase 1007-1243 7.5e-51 168.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 1007-1243
Range on HMM: 1-234/235.0
NEPKNHDPNFLPYDDNRVRLTPCRDNRHgYVNASSISATVgTkQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTEDMS--------YIPRNSHQRL
|. ||  ...||||..||.|.   ..   |.||. .. .  . .. .|..| | .  |.  ||..||. .| ..|.||...         | |..... |
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyk.e.kkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EFGQFQVYQE--FSQTTDRCTTIKLRLYHVPSR-RYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlastqevppgHNTNPPVLLHCLEGGGRSGV
..|...|  .   .. ....|. ||.| .  .. . |.|. |.| .| ....|......||....... .          .... ||. || .| ||.|.
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvVhCsaGvgRtgt

TLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
 ...|.||  |...|..|.  .. .||.|| ... ||.||.|.|....
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1007-1243 7.5e-51 168.2 In-house 1-234 (235) alignment 
Range on Protein: 1007-1243
Range on HMM: 1-234/235.0
NEPKNHDPNFLPYDDNRVRLTPCRDNRHgYVNASSISATVgTkQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTEDMS--------YIPRNSHQRL
|. ||  ...||||..||.|.   ..   |.||. .. .  . .. .|..| | .  |.  ||..||. .| ..|.||...         | |..... |
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyk.e.kkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EFGQFQVYQE--FSQTTDRCTTIKLRLYHVPSR-RYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlastqevppgHNTNPPVLLHCLEGGGRSGV
..|...|  .   .. ....|. ||.| .  .. . |.|. |.| .| ....|......||....... .          .... ||. || .| ||.|.
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..........eaksgpvvVhCsaGvgRtgt

TLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
 ...|.||  |...|..|.  .. .||.|| ... ||.||.|.|....
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
DSPc_SM00195 983-1247 3.7e-50 166.1 In-house 2-263 (263) alignment 
Range on Protein: 983-1247
Range on HMM: 2-263/263.0
LFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVV
| .|||.. . ...   ..|  ..|. ||   |.||||..||.|..  . . . |.||. |. .  .|.. ||..| |. | |.. ||..||| .| ..|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPl.pstvedFWrmvweekvkiiv

QLTEDMS--------YIPRNSHQRLEFGQFQVYQEFSQTTD-RCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAStqev
 |||..         | |..|..  .||...|     ....  ... .|.| .   .  |.|  .|| .| ....| . ...|..|..... .  |    
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....

ppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
      ..|.. ||  | ||.|. .|.|..|  |......||  .. .||.|| ... .|.||.|||. .. |.|
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 983-1247 3.7e-50 166.1 In-house 2-263 (263) alignment 
Range on Protein: 983-1247
Range on HMM: 2-263/263.0
LFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVV
| .|||.. . ...   ..|  ..|. ||   |.||||..||.|..  . . . |.||. |. .  .|.. ||..| |. | |.. ||..||| .| ..|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPl.pstvedFWrmvweekvkiiv

QLTEDMS--------YIPRNSHQRLEFGQFQVYQEFSQTTD-RCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAStqev
 |||..         | |..|..  .||...|     ....  ... .|.| .   .  |.|  .|| .| ....| . ...|..|..... .  |    
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....

ppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
      ..|.. ||  | ||.|. .|.|..|  |......||  .. .||.|| ... .|.||.|||. .. |.|
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyik
0040439 (Phosphotyrosine protein) phosphatases II 999-1248 1.1e-48 161.4 In-house 3-248 (249) alignment 
Range on Protein: 999-1248
Range on HMM: 3-248/249.0
YECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSISATVGTKQrfYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM--------SY
|..|||.|| .||  |..|||| .||.|..... . ..|.||| |. .  ...  .|..| | .  |.  ||. .|| ..  .| ||...         |
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpe.tvedfwrmlwelgitvivmLtslvelgrekcaqy

IPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAStqevppghNTNPPVLLHCLEG
 |    . ||.|.|.|     .. | .|. .|.|...     | |. .|| || ....| .....|||.|...... .         ... ||| ||  |
wpl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel........pkggpvlVHCsaG

GGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
 ||.|. ..|.|.|. |... ..|.. .. .||.||  ..... ||.|.|..|. .|..
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
0042113 (Phosphotyrosine protein) phosphatases II 999-1247 8e-47 155.1 In-house 1-244 (245) alignment 
Range on Protein: 999-1247
Range on HMM: 1-244/245.0
YECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSIsaTVGTKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM--------SY
|..|||.|| .||  ...||||..||.|.|   .  ..|.||| .  ..    . .|..| |..  |   ||. .|| ..  .| |||..         |
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvkcaqy

IPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAstqevppghNTNPPVLLHCLEG
 |   .. |..|.|.|.    .. | .|. .|.. ....  .| |. ..| .| ....| .....|||||...... .         . | ||| ||  |
wpl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.........dsngpvlVHCsaG

GGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
 ||.|. ..|.|.|. |... ..... .. .|| ||  ..... ||.|.| .|. .||
vgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_PTPN3_pd Subfamily PTPN3 972-1243 1.7e-44 146.9 In-house 6-272 (280) alignment 
Range on Protein: 972-1243
Range on HMM: 6-272/280.0
QILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTpcrDNRHGYVNASSISATVGTKQRF--YIVAQSPQEpLTMRIFW
. | . |.  .....||.. ....    ..| . || .||   . ||||. ||.|.   ...  |.||. ..  . ...    ||..| | .  |.  ||
lllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk...esetdyinanyvnmeipstglvnryiatqGPla.ktatdfW

QCVWEADVYLVVQLTEDM--------SYIPRnSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEEL
| ||| .. |.| ||. .         | |. ....||.|.|.|. | ...|  . . .| | .  ... |..  ||| .|.... | | ..||.|.|..
qmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv

NSVRlastqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
...|          . .. ||..||  | ||.|| .. .. |  ....|.. .. .. ..| || ..... .||||. . ..
rklr..........sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
0037934 (Phosphotyrosine protein) phosphatases II 1000-1246 1.6e-42 141.1 In-house 3-242 (243) alignment 
Range on Protein: 1000-1246
Range on HMM: 3-242/243.0
ECALLEENEPKNHDPNFLPYDDNRVRLtpcrDNrHGYVNASSISATvgtkqRFYIVAQSPQEPlTMRI----FWQCVWEADVYLVVQLTEDM--------
 .|||.|| .||. ...||||..||.|    .. ..|.||. |  |     . .|. | | .  |       ||. .|| ..  .| |||..        
siallpenlsknrysdilpydhsrvkl....eg.sdyinanliyvt.....prliatqgPlpe.tveddlasfwrmlwelgitvivmltelvElgrekca

SYIPrNSHqrlEFGQFQVYQEFSQTTDRCTTIKLRLYHVP-SRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNtnPPVLLHC
 | | ...   ..|.|.|    ....| .|  .|.|.... .  .| |. ..|  | ....| .....||||.|....  . .. .   ..   |||.||
qywp.gev...tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpvlVHC

LEGGGRSGVTLTADLLLYTLdhneDLDIPRVIGQLRHQRDS-IIPSLAQYKFIYNLLITYL
  | ||.|. ..|.|.|. |    ..|.  .. .|| ||   ..... ||.|.| .|. .|
saGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPRD_pd Subfamily PTPRD 978-1247 1.2e-41 138.0 In-house 20-282 (564) alignment 
Range on Protein: 978-1247
Range on HMM: 20-282/564.0
LSDSQLFMEFERIPKRrEHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSISATVgtKQRFYIVAQSPQEPlTMRIFWQCVWEAD
 || ....|...| .. ..   | |  ..| .||   | ..|| .||.|.. .  .   |.||| | .    |.. || .| | .. |.. ||. ||| .
nsdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlae.tiedFWRmvweqn

VYLVVQLTEDM--------SYIPRNsHqRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlAs
.  .| ||.          .| | . . . ..|...|  | ...    .  ...| .  |.  | |   .. .| ... |   ...||.... ....   
sstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e.

tqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
        ... |.. ||  | ||.|. .. | .|  . .....||  .. .||.||. .. .  || ||.. .  .|.
........pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
subfamily_PTPN6_pd Subfamily PTPN6 975-1249 8.1e-40 131.7 In-house 20-300 (306) alignment 
Range on Protein: 975-1249
Range on HMM: 20-300/306.0
DQKLSDSQLFMEFERIPKRREHALYE--CALLEENEPKNHDPNFLPYDDNRVRLTpcRDNRHG--YVNASSISATVGTKQRFYIVAQSPQePLTMRIFWQ
...|. . .  |||.. .. .. |..   .   ||. ||   | ||.|..|| |.  ...  |  |.||. |.  | .... || .|    . |.  ||.
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgcl.ettvsdFWr

CVWEADVYLVVQLTEDM--------SYIPRNSHQRLeFGQFQVYQEFSQTTDRCTTIKLRLYH-VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEEL
 ||. .  ..| .|...         | | .....  .|. .| .  ...... .  .|.. .   ... |.|. ... .| ....|.| ...|||||..
mvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledv

NSVRLASTQEvppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDH---NEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRT
|. .  ....      .. |.. || .| || |  .  |.|| .. .   . |.|| ... ..|.||  ..   .||||.|. . .|....
nrkqeeleea......eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 981-1249 1.5e-37 124.3 In-house 15-279 (281) alignment 
Range on Protein: 981-1249
Range on HMM: 15-279/281.0
SQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATVGTKQrfYIVAQSPQePLTMRIFWQCVWEADVYL
. . .|.| . .   .   . .  .||  ||   |   ||  ||..||  .|    |.||. ...  | |.  ||..|.|  | .. .||| ||| .| .
aGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgeke..yiatqgPv.PaslvafWqmvweqkvsa

VVQLTEDMS--------YIPrNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLyHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLastqe
.| .|...         | | . ...|..|...| .. .... .  . |..| .  |   |.|  |.|  | ..  | . ...|.| .|.....      
ivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlklte.....

vppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLD-HNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRT
    ..|. |...||  | ||.|. .. | |. ... ..|.||.  |. .||..|  .. ...||.|.|  .. .|...
....kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_Ptp69D_pd Subfamily Ptp69D 979-1248 1.6e-36 121.0 In-house 20-288 (307) alignment 
Range on Protein: 979-1248
Range on HMM: 20-288/307.0
SDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCR-DNRHGYVNASSISATvgTKQRFYIVAQSPQEpLTMRIFWQCVWEADV
.|  |  |.|....|  .   . .  .||  ||  ..  ..|..||.|..   ..   |.||| | .    ... .|.|| | |  |.  ||. ..| .|
tdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgy..kekkkfiaaqdPve.atigDfWRmiaeqev

YLVVQLTEDMSYIP----RN--SHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVP-----SRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRL
.|.| |..   .      .     .  ..|.  |    .....  .  .| . ..          | |   .|  | . . |.  .  |...|.....  
tlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyk

AStqevppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
 .          . |...||  | ||||. .. |.||  |  .. .||  .. .||.||. .. ||.||.|.|  |. | . 
ln..........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPN13_pd Subfamily PTPN13 975-1248 3.5e-36 119.9 In-house 5-271 (273) alignment 
Range on Protein: 975-1248
Range on HMM: 5-271/273.0
DQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTpcrdNRHGYVNASSISATVGTKQRFYIVAQSPQePLTMRIFWQCVWE
 .|| . |   ||. . . .     | .  .||. ||   | ||||. ||.|     .  ||.||| | ..|| ..  ||..| |  | |.. ||| |||
qkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg....deggyinaslikvpvgkdeyeyiacqGPl.Petvkdfwqmvwe

ADVYLVVQLTEDM--------SYIPRNSHQRLEFGQ-FQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVr
 .. ... .| .          | | . ...|   . ..| ..  |  |  .  .| . .. |.. | |  |....| . . |.  ...| |. |.... 
qkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl.

lastqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
          .. . |.. ||  | ||||. .| | .|  .......|.  .. .||.||.... .  || |.|. ... ||.
..........qtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 982-1246 5.3e-36 119.1 In-house 22-279 (288) alignment 
Range on Protein: 982-1246
Range on HMM: 22-279/288.0
QLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPC-RDNRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLV
..  |.. ...  ..   . . | .|..||  .| |||| .||.|.     .   |.||| |  .   |.. || .|.|  . |.  ||. |.| ..  .
gfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge..kkkkkyiatqgPl.adtvndfWelvyenktsti

VQLTED--------MSYIPRNShQRLEFGQFQVYQEFSQTTDRCTTIKLRLYhvPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEElnsVRLASTQEv
| |||           | | .  .  ..|...|    |....  .. || |    .   . .  .||  |.... |.. . .|..|.    |  |.... 
vmltelveggktkCeeYWPdad.kpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrq...vkvanqad.

ppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
        |.. || .| ||.|. ...| |. ...... .|.  .. .||.|| ...  | || |||. |..  
......tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 980-1247 1.9e-35 117.5 In-house 19-281 (318) alignment 
Range on Protein: 980-1247
Range on HMM: 19-281/318.0
DSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVY
. .|. |.||. . .|..    .| . |. ||   | |.||. ||.|..  ..    |.||. |     .... || ||.|  | |.. ||. ||| .  
elllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGy..rrkkayiaaqaPl.petieDfWrmvWeqnsa

LVVQLTEDMSYIPRNS------HQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAStqev
..| ||. .    .        ..  ..|. .|  . . ...  .  .... .  .   | |   .|..|.... | .. ..||.. . ... . |    
vivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqks....

ppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
     .. |.. ||  | || || .. | ||  . ... .|.  .. |||.||. ..    ||.|||. |. .|.
.....gagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_PTPRB_pd Subfamily PTPRB 977-1248 5.2e-35 115.9 In-house 21-287 (293) alignment 
Range on Protein: 977-1248
Range on HMM: 21-287/293.0
KLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEA
. || ..  |.|.. .  ..   ..| |..|. ||   | |||| .||.|.. .|..   |.||. |.    . .| .|..| |  | |.  ||. ||| 
adsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgy..nsprefiatqGPl.petvddfWrmvwek

DVYLVVQLTEDM--------SYIPRNShQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHvpSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRla
 .  .| ||. .         | |... .   .|. .|    .....  .. .|.. .  ... |.|  ...  |.. . | . . .|||.......   
kssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreai..

sTQevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
 ..     .... |.. ||  | ||.|. .. | || ...... .||  .. .||..| ... . .|| ||.. ....|..
.ek.....taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 976-1247 1.1e-34 115.0 In-house 22-291 (298) alignment 
Range on Protein: 976-1247
Range on HMM: 22-291/298.0
QKLSDSQLFMEFERIPKRRE---HALYECALLEENEPKNHDPNFLPYDDNRVRLTP-CRDNRHGYVNASSISATVGTKqrFYIVAQSPQEPlTMRIFWQC
.| . ... .||.|. .  .   .. .| |  .||. ||  .. ...|  ||.|.    |.   |.||| ..|  |..   .|..| | .. |.  ||. 
kkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn..afiatqaPlte.tvedFWrm

VWEADVYLVVQLTE--D------MSYIPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEElns
|.| |.  .| ||.  .        | |   ..  ..|...|    ...    .. || . .  ... |.|  |..  |...  |.  .  ||.|..   
vteedigtiVmltnleeldktkyhkywPd..egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrk...

VRLaSTQEvppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
||  |.|.     . | ||...| .| ||||     | .|  . ... .|. .|.  ||..|  .. . .||.|||.. . .|.
vra.sqqq.....agnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 976-1247 4.2e-34 113.0 In-house 19-284 (319) alignment 
Range on Protein: 976-1247
Range on HMM: 19-284/319.0
QkLSDSQLFMEFERIPKRREHaLYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIFWQCVWE
.  .. .|  ||. . .  .   .. |  |||..||  .| |.||  || |..  .     |.||| | .    ... .| .|.| |  |.  ||. |||
s.tgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgy..qerekfiatqaPlen.tiedfWrmvWe

ADVYLVVQLTEDMSYIPRNSHQR------LEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRR-YRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlA
 ... || ||..   .  . ..        |.|.. |  |  . ..     || | .  |    |.|   || .|.... |..    ||.|....    .
eessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk...s

STQevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
  .      ... |.  || .| || |  .. |  |  . ... ||.  .. .|| ||. ..   .||||||. |. ...
rek......tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_CG7180_pd Subfamily CG7180 1000-1245 4.6e-34 112.4 In-house 35-289 (296) alignment 
Range on Protein: 1000-1245
Range on HMM: 35-289/296.0
ECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM-------SYIP
 ..| .||  ||.|.. .||| ||| |.    . .  |.||. . .   .|.. ||| . |..  |.  ||. |.. ..  || ||. .       ||.|
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsf..lkkkeyivteapkke.tvdefWrlvydeeisavvvLtktfdfakmypsywp

RNShqRLEFGQFQVYQEFSQTTDRCTTIKLRLYHV----------PSRRYRSVWYLQYADWAE-QNCPRDVNHFLDFLEELNSVRLAStqevpPGHNTNP
 .|  . ..|.. |    ...    .. ...|..            .   | |  .|.  |   ...|   | ......  ...|        . .... 
nks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv.....dedpeeg

PVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITY
||. .. .|..|||| |..|  |  ....| .|. . . .||..|  .. .  .||.||..|  .
PvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_PTPN23_pd Subfamily PTPN23 994-1248 5.3e-34 112.3 In-house 30-282 (288) alignment 
Range on Protein: 994-1248
Range on HMM: 30-282/288.0
REHALYECALLEENEPKNHDPNFLPYDDNRVRLTpcrDNRHGYVNASSISATVGTKQRFyIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTED-----M-
.|     .|. . .  ||   . |||| ||| |    ...  |.||| .   . .   | |..|.|... |.  ||. |.|  . ..| |..        
kearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdf.iatqaPlqs.tlnDFWlmvyeqkssviVmllskeelgkpk

--SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPghntnpPVLLH
  .| | .  .  .||...|  .  ..|. .   .|.| . .... .|| .||.  |.|   |   ...|.||.| .|   |  ...        |...|
vdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt......Plvvh

CLEGGGRSGVTL-TADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
|. | ||.||       .  .  .|  |||..|. .||.||   .   .|.|| |.  ... .|
CsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_PTPN12_pd Subfamily PTPN12 998-1248 2.1e-33 110.5 In-house 31-279 (290) alignment 
Range on Protein: 998-1248
Range on HMM: 31-279/290.0
LYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTEDM--------S
  |..  |||  ||   . |||| .|| |.  ...   .|.||..|  .  ...  || ||.|  | |.  ||. .|| .| .|| . . .         
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgv..egkleyiaaqgPL.pktlddfWrmiweknveivvmaCrevelgkkkCer

YIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLrLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLastqevppghNTNPPVLLHCLE
| | . ...||||.|.| .|  ...|   .|.  |    ..  |.|  ..| .| ....|. ... |...|......           . . |...||  
YWpeegeeelefgefevtleeekavdddflirt.LkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..........sedaPlvvhCsa

GGGRSGVTLTADLLLYTLDHN---EDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
| || |. .. |.    | ..   |.||.  .. .||.|| ... .  ||...|. .. ....
GvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 971-1247 2.9e-33 110.3 In-house 11-284 (305) alignment 
Range on Protein: 971-1247
Range on HMM: 11-284/305.0
CQILDQKLSDSQ-LFMEFERIPKRREHAlyECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIF
..| ...  ... | .... .... |    .    |.|. ||.  .  ..||.|..||.  ..  . |.||| . .    ..  |||||.| .  |.. |
ayikearvysdkgleaqykslyeeeesi..dvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgy..krkkkyivaqgPlkn.tvadf

WQCVWEADVYLVVQLT----ED----MSYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYH-VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLE
|. ..|  |  .|.||    ..      | | .  .. |||.|.|  . ..|.   .. ||..     ..  |.|  .|  || ..  |.    .|....
WrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslik

ELNSVRlastqEvppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
...  .     .    .. . |.| || .| ||.|| .. |. |  | . | .|. .|. |||..|  .. .|.|| |... |  ...
rvqkdq.....k....kdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPN9_pd Subfamily PTPN9 981-1248 2.2e-31 104.0 In-house 16-292 (297) alignment 
Range on Protein: 981-1248
Range on HMM: 16-292/297.0
SQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYL
. |  |.. | ..  .  .... |  |  ||   . | ||. || |.   ..    |.||. .      ... .| .| |  . |.. ||. ||| .|  
rGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGy..kqkkafiatqGpl.kktvsdfWrmvWeqevlv

VVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQE
.|  |  .         | | ..... |||...| .   ....  .. .| ...|  .. |.| . |.  | .   |.. . .||.||.  . . ....|
ivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavke

VPP---GHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
. .   || ..||...||  | ||.|   | |. |  |.. . .|.  .. .|| ||   |    ||.| |  .. | ..
lgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 980-1243 4.9e-31 103.2 In-house 33-288 (319) alignment 
Range on Protein: 980-1243
Range on HMM: 33-288/319.0
DSQLFMEFERIPKRRE-HALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADV
 ..| .|| |..|.    |  . | |..|  ||   | |..| |.|.| .        |.||| ..     ..  || || |. . |.  ||. .|| ..
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGy..qrkdkyiaaqGPl.dntladfWrmiweync

YLVVQLTEDMS--YIPRNSHqrLEFGQFQVYQEFSQTTDRCTTIKLRLYH-VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFleeLNSVRLASTQEvpp
  .| ||.|.   | | .     . ..|.|  .  . |.  .  ...| .    .  |..    .  | ..  |     .. .   .. ||   ..|   
stivlltkdkcsqywplkiv..ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrl...vkkvrhltske...

ghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
  | . ....||  | ||.|| .. | ||  ..... .|. ... .|| ||. .. .|.||||||  |.
..nhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 986-1244 8.4e-30 99.2 In-house 3-253 (284) alignment 
Range on Protein: 986-1244
Range on HMM: 3-253/284.0
EFERIPKRR-EHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQL
|| |..|.  . .  . | |..|  ||   . |..| |.|.| .   .    |.||| |.     ..  || .| |. . |.  ||. .|| ..  .| |
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGy..qrkdkyiatqGPl.dntladfWrmiweyncstivll

TEDMS--YIPRNSHqrLEFGQFQVYQEFSQTTDRCTTIKLRLYH-VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFleeLNSVRLASTQEvppghNTNP
|.|.   | | .     . ..|.|  .  . ..  .  ...| .    .  |..    .  | ..  |    ... .   .. ||  ...|     | . 
tkdkcsqywplkiv..ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrl...vkkvrhltske.....nhra

PVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLIT
....||  | ||.|| .. | ||  ..... .|. ... .|| ||.... .|.||||||  |. 
nivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 981-1250 1.2e-29 98.3 In-house 5-272 (274) alignment 
Range on Protein: 981-1250
Range on HMM: 5-272/274.0
SQLFMEFERIPKRRehALYECAlLEENEPKNHDPNFLPYDDNRVRLTP--CRDNRHGYVNASSISATvGTKQRFYIVAQSPQePLTMRIFWQCVWEADVY
 .|  ||  .|        |   .  .. ||   . || .  || |..   .|.   |.||  |    ..... |. .| |  | |.  ||. ... .| 
kdlekeflelPlnf..dqeeld.vfgsqtknryktilPnensrvllesessededssyinanyikGy.deeskayvatqGPl.pntvadfWrmiyqeevq

LVVQLT---EDM-----SYIPRNSHQ--RLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSrrYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAS
..| ||   |        | | . .     ..|....  |   ...  .  || | .. .   ||| .  |.|| ... |.|.|..||...| .. | ..
vivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreee

TQEVPPGhntnppvLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTR
.... |        ..||  | || |. ..... .  |.... .|. ... .|| .|  .. .  ||..|.. |. ||||. 
naklapv.......vvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1001-1251 3.9e-29 96.5 In-house 38-283 (315) alignment 
Range on Protein: 1001-1251
Range on HMM: 38-283/315.0
CALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTE----DM----SYIP
 |  ..| .||   | ||.| .||.|    |.  . |.||| | .    ... || .| |. . ..  ||. |.. .|  .| .|.    |      | |
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksv..dddkayiasqgPl.kasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

RNSHQRLEFGQFQVYQeFSQTTDrCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlaSTqevppGHNtNPPVLLHCLEGGG
 .  .  |||...|   .|  .|   ... .|    |  .| |   |. .| ..  ....  .| .. |. .    .      |.. . ..|.||. | |
drkadsvefGsikvel.lslead.tdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevka....dn.....gkk.efsllvhcsaGvG

RSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK-RTRL
|.|| ...|  .  . ... .|. ... .|| .|  .. .  .| |||. .  .|. |  |
rtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntl
subfamily_PTPRG_pd Subfamily PTPRG 980-1246 4.4e-29 96.1 In-house 18-287 (563) alignment 
Range on Protein: 980-1246
Range on HMM: 18-287/563.0
DSQLFMEFERIPKRREH--ALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRD--NRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEA
|  .  ||| . ..  .    .| .  .||  || . | ..||  ||.|.|  .  ... |.||. |      |.. .|..| |  . |.  ||. .|| 
digfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGy..qkskafiatqgpl.kdtfddFWrmiWeq

DVYLVVQLTE--------DMSYIPRnsHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVP-----S-RRYRSVWYLQYADWAEQNCPRDVNHFLDFLEEL
 | ..| .|.           | |.   . ...|..|| .. ....   |. .| . ..      .    . |   .|..| ... |      | | .  
nvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks

nsvrlaSTQEvppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
      |. .    ...  |.. || .|.||.|. .  | ||  . ...  .. ... ..| ||. .. .  || |... |.  .
......saan....kaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleai
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 982-1243 1.1e-28 95.1 In-house 24-276 (315) alignment 
Range on Protein: 982-1243
Range on HMM: 24-276/315.0
Q-LFMEFERIPKRREHALyECALLEENEPKNHDPNFLPYDDNRVRL-TPCRDNRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYL
. .  ..| ||  . | | . |   ||  ||   | ..||  ||.|     |.   ||||. |     .|.| || ||.|. . ... ||. |.| |.  
ngfkqdyesipggqlhpl.dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGy..nkkrryiaaqgpn.vasvkdfwrlvfeedigk

VVQLTEDMSYIPRNSH-----QRLEFGQFQVYQEFSQTTDRCTTIKLrlYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEElnsVRLASTQEVpp
.| ||. ..   |..      ... .|.. | .   .  .. |   |    |   . | |  |.|. | . . |.    ....      |.   |..|  
ivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirt...vkqhhtnsv..

ghntnPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
      ....|| .| ||.|  .| | .|  .. .. .|. ..| ..|..|  .. ...||.|||. |.
.....gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1006-1247 1.6e-28 94.6 In-house 8-243 (250) alignment 
Range on Protein: 1006-1247
Range on HMM: 8-243/250.0
ENEPKNHDPNFLPYDDNRVRLTPCR-DNRHGYVNASSISATVGTkqRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTED-------MSYIPRNSHQr
.|. || . .....|  || | . . |.   |.||| . .  ..  . .|..|.| .. |.  ||. |.| ..  .| ||.          |.| .  . 
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqa.tiedfWrmvleeksgtivmLtnLkesektyhqywPvekae.

lEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNsvrlASTQEVppghnTNPPVLLHCLEGGGRSGVTL
 ..|. .|    ...    |. || | .      | |  |..  | ..  |.  .  |..|....    || |..      | ||...| .| ||||  .
.kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvq....asqqqa.....gnaPvivqCsaGvgrsGafi

TADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
. | .|  | ... .|. .|| .||..|   . ||.|| |.|.... .|.
aidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPRA_pd Subfamily PTPRA 974-1245 2.4e-28 94.0 In-house 23-294 (330) alignment 
Range on Protein: 974-1245
Range on HMM: 23-294/330.0
LDQK-LSDSQLF-MEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIFWQ
....   |..||  ||. .|  . .| .| |  |||. ||  .| |||| .|| |.. . .    |.||| |      ..  .| || |.|  |.  ||.
irirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGy..kekdkfiaaqGPkee.tvedfwr

CVWEADVYLVVQLTEDMSYIPRNSH------QRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRR----YRSVWYLQYADWAEQNCPRDVNHFLDFLEE
 .|| .   .| |||         .        . .|. .|  | .. .   |  |. . ..|  .     | |  . .  | .   | .    |..|..
miweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkk

LNSVRlasTQevppghNTNpPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITY
.....    |      ... |. .||  | ||.|  .. | .|  .  .. .|. ... .|| ||  .. .. ||.|||. |  |
vkkln...qq......sag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1004-1251 9.3e-28 91.6 In-house 40-282 (515) alignment 
Range on Protein: 1004-1251
Range on HMM: 40-282/515.0
LEENEPKNHDPNFLPYDDNRVRLTPCRDNRH-GYVNASSISATVGtkQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTE----DMS----YIPRNS
 | | .||   | |||| .||.|    || |  |.||| | .     .. || .| |..  ..  ||. |.. .|  .. .|.    | .    | |   
eeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn..dkayiasqgPnk.asvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

HQRLEFGQFQVYQeFSQTTdRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlaSTqevppGHnTNPPVLLHCLEGGGRSG
 . ..||...|    |  .    .|| .|  . .  .| |   .. .| ..  |.. . .| .. |. .    ..     |.  . |...||. | || |
gdsvkfGsikvel.vslea.ctggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevka....dh.....gq.ythpliihcsaGvGrtG

VTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK-RTRL
| ...|  .      . .|. ... ..| .|  ..    || |||. .  .|. |  |
vvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1006-1248 1.1e-27 91.7 In-house 19-266 (270) alignment 
Range on Protein: 1006-1248
Range on HMM: 19-266/270.0
ENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSISATVGTKQRfYIVAQSPQePLTMRIFWQCVWEADVYLVVQ---LTED-----MSYIPRNSHQ
 ..  |   . ||    |||| . .. ..  |.||  .    | |.. || |..|. | |.. ||. .||  |  .|    |.|.       | | ....
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkk.YiaamgPl.pttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

--RLEFGQFQVYQEFSQTTDRCTTIKLRLYhVPSRRYRSVwYLQYADWAEQNCPRDVN---HFLDFLEELNSVRLASTQevppgHNTNPPVLLHCLEGGG
  .||.|. .| .. .. ..   . .|||    . . | |   .| .| ..  ||. .   .  . |. |. ||  ...     .. . |.| || .| |
kvkledgkikvlalseekeegyiltrlrle.ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrseke.....ldkaePllvHcsaGvg

RSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
|.|. .. |  . .|.... .|. ..| .||..|  ..    ||.|.|. ...| .|
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPRK_pd Subfamily PTPRK 986-1242 2.9e-27 90.3 In-house 27-273 (314) alignment 
Range on Protein: 986-1242
Range on HMM: 27-273/314.0
EFERIPKRrehalYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQL-
|.| ...      ...|  .||. ||   . |.||  ||.|..  ..    |.||. | .   .. . .||.| | .  |.. ||. |.. .   .| | 
eyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsy..krpaafivtqgPlqe.tvkdfWrlvydencasivmlt

--TEDM-----SYIPRNSHQrleFGQFQVYQEFSQTTDRCTTIKLRLYH--VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAstqevpp
  .| .      | | ....   .|...|    ...     .  .|...   .   .| |  .|.  |.. . |   . .|... .... .         
elvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.......

ghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLL
   .. ....||. |.||.|. .. | .|  ..... .|.  .. .|| ..  ..    ||||||. .
...eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1007-1246 4.6e-27 89.9 In-house 51-284 (297) alignment 
Range on Protein: 1007-1246
Range on HMM: 51-284/297.0
NEPKNHDPNFLPYDDNRVRLTPCRDN-RHGYVNASSISATvgtKQRfYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTEDM-------SYIPRNSHQRl
| .|.   | |||| .||.|    |.    ||||| . .    |.| .|  | |. . |.  ||. |.. .|  .| |..|         | . .. .  
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgn...khr.littqmPm.katvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt.

eFGQFQVYQEfsQTTDRCTTIK--LRLYHVPSRRYRSVWYLQYADWAEQNCPR--DVNHFLDFLEELNSVRlastqevpPGHNTNpPVLLHCLEGGGRSG
 ||.  |  .   ...|.  ||  | . .  ..  | |   |. .| ... .|  ... .|....|.. .          ... . |.|.||| | || |
.fGdvsvvll..svsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdf........sqnaeg.PllvhclaGvGrtg

VTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
| || |  .    .....||  .. .||..|  ..    ||||.|.... .|
vlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_PTPRN_pd Subfamily PTPRN 985-1241 1.5e-26 87.8 In-house 33-287 (297) alignment 
Range on Protein: 985-1241
Range on HMM: 33-287/297.0
MEFERIPK-RREHALYECALLEENEPKNHDPNFLPYDDNRVRLTP-CRDNRHGYVNASSISATvGTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQ
 |.| . . . | .  | |  |.|  ||   ..||||..||.|.    .... |.|||.|  .   ..  || .|.|  . |.  ||| |||  | ..|.
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildh.dprapayiatqgpl.astvadfwqmvweqGvvvivn

LTEDMS--------YIPRNSHQRLEFGQFQVYQEFSQTTDRCtTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLastqevpp
||.           | | . ..  .. . ..  |   . |      . |  . ... |.|  . .  | |...|   . .|.|   .|            
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddyl.vrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr........

GhnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDH-NEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNL
|     |...|| .| ||.|| .  ||.|  | .   ..||   .  || ||. .. . .|..|..  
G..rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 987-1248 1.8e-26 87.7 In-house 26-285 (290) alignment 
Range on Protein: 987-1248
Range on HMM: 26-285/290.0
FERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDN---RHGYVNASSISATvgTKQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQL
|... .  ..   . .| ..|...|   |...|||||. | |  ..    . |.||. |      ... ||..|.| .  |.. ||. .|. .|  .| |
fkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgy..kekkqyiatqgpvs.ntlvdFWkliwqekvtiivml

TEDM--------SYIPRNSHQRleFGQFQVYQEFSQTTDRCTTIKLRLYHVPS-RRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlasTQEvpp
|. .         | | .. ..  .|.|..     .|... ...||.. .  |  . .||  .|   | ..    . .  |  .|| .      ||    
tniieegkvkCqqYWpdsdtka..ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk.....tqr...

gHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
 ...| ....|| .. |||.| ..|.  .     .   |.  |. ..| |.   . .  ||..|.....|||..
.krgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPN1_pd Subfamily PTPN1 1000-1244 1.9e-25 84.2 In-house 25-269 (290) alignment 
Range on Protein: 1000-1244
Range on HMM: 25-269/290.0
ECALLEENEPKNHDPNFLPYDDNRVRLTPCrDNrhGYVNASSISatVGTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTED--------MSYIP
. | |.|| ..|   .  |||  |..|    ||   |.||| .   .   .| ||..| |  | |.  ||| ||| .   || | .         ..| |
reaklpenrnlnryrdvspydhsriklera.dn..dyinaslve..leeakrsyiltqGPl.pntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywP

RNSH-QRLEFG--QFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEElnsVRLASTQEvppgHNTNpPVLLHCLE
.. . . |..   ...|     ....  |  .|.|  . ... |..    |  |..   |.  . ||.|| .   || . .      ..   |...||  
qgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfk...vresGsls....sdvG.pavihcsa

GGGRSGVTLTADLLLYTLDHNED---LDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLIT
| ||||    .| .|  .....|   .|| .|. .||..|  .|    | .| |  .. 
GiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 984-1247 4e-25 83.4 In-house 26-279 (287) alignment 
Range on Protein: 984-1247
Range on HMM: 26-279/287.0
FMEFERIPKRREHALyeCALLEENEPKNHDPNFLPYDDNRVRLTpcrDNRHGYVNASSISATvgTKQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQL
|. .|.. .|...     .. ..|..||   ..|..|..|| |    .... |.||. | .    ... .|.|.||    |.| ||. ...  |  .| |
ftvleqvtqredevt..hniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgy..kekkafiiaesPmf.ntarnfWkliddrnvtaivml

TED------MSYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVP-SRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNsvrlaSTQEvppgH
...      . |    ... . .|....     .... ..  ||.. .   .   ..|   |...| ..    . .  |  .|| .      ||     .
cqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemy.....ktqr....k

NTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
..| ... || .. |||.. . |.  .   . .  .|. .|. . | |.   .   .|||||......||.
rgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 982-1248 1.5e-24 81.3 In-house 11-279 (287) alignment 
Range on Protein: 982-1248
Range on HMM: 11-279/287.0
QLFMEFERIPKRRE--HALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYL
..  |.... .  |   |..  |    .  ||   . ||.||.|| |.   .    |.||  ...   |..  .|.||.|  . |.| ||. |.|  .  
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasy..tddeafiaaqgPi.aatvrdfwravletrsas

VVQLTEDM--------SYIPRNsHQRLEFGQFQVYQ-EFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNsvrlaSTQ
|. .| ..         | | . .. .  | . |   ....     ..  ||| .. .|  | |  |.. .| ..  .     .. |  . .        
vitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvk.....qhi

EVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
|.    .   |...|.  | ||||. |.   |.  |     .|. .|. .|| .| ... .  |....|. |.|| | 
elardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1000-1242 4.2e-24 79.9 In-house 26-262 (283) alignment 
Range on Protein: 1000-1242
Range on HMM: 26-262/283.0
ECALLEENEPKNHDPNFLPYDDNRVRLTPCRDnrhGYVNASSISATVG-TKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDMS--------YI
..|  .||..||.  . .|.| .||.| .       |.||. |  .    ... ||.|||| .  |.. ||. |.. ..  .| ||. .         | 
diasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldr.tvvdfWkmvfdekitaivmltklqedlrikCsqyW

PRNShqRLEFGQFQVYQEfSQTTDRCTTIKLRLYHVP--SRRYRSVWYLQYADWAEQNCPRDVNHFLDFleelNSVRlaSTQEvppgHNTNPPVLLHCLE
|..     ..|.| |  .  .|| .  .||. | .|   ..    . . |. || | .    .| .. |    | |.  | |     .. . |...|| .
PkrG..sedyGeftvtlr.kettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf....nkvi..slqt....eskkgPivvhCst

GGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLL
|.||..| ..|   .  .  .  .|.. |.  .| ||  .. .| |||....| 
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
0051429 (Phosphotyrosine protein) phosphatases II 1034-1247 1.1e-23 79.7 In-house 4-226 (272) alignment 
Range on Protein: 1034-1247
Range on HMM: 4-226/272.0
HGYVNASSISATVG-TKQRFYIVAQSPQEPlTMRIFWQCvWEADVYLVVQLTEDM-------SYIP-----------RNSHQRLEFGQFQVYQEFSQTTD
 ||.||. ..   . .| .... .. | .  | . ||.  .| ..  .| |....       .. .            .|... ..|.. |.  . ....
sgyiNardvggygrvvkpgrlyrsggplpl.taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

RCTTIKLRLYHV-PSRRYRSVWYLQYADWAEQNCPRDVnhFLDFLEELNSvrlastqevppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLD
 ..  .|.|... .   .| |. |.| ||   . |..   .|..||.|..               . ||| ||  | .|.|.   ..|||. ....  .|
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...............ggpvlvHCsaGkdRTGtvvallllllgvsletivd

--------IPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
        . ... .|| ||  .... .||.|.|. |. .|.
dYlltnlyleeaveelraqrpgavqteeqylflyeallellr
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 983-1246 1.8e-23 78.2 In-house 25-288 (325) alignment 
Range on Protein: 983-1246
Range on HMM: 25-288/325.0
LFMEFERIPKRREHAlYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRH-GYVNASSISATVgtKQRFYIVAQSPQePLTMRIFWQCV--WEADVYL
.  ||. .|     | .. | . ||  ||  .| ...| .|| |   .|. .  |.||| .   .  |.  .. ||.|. . |.  .|. |  |.. | .
fahefgllpsddgia.kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddk..kkdvflaaqaPl.tatindlWrlvldWrcsvvv

VVQLTED-----MSYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlastQEVPP
|.   .        | |..  .  .|| ..|     ..       .| .  |     |||  .|.  | .   ..    .. .|. .. |     . |  
vlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs....ervta

GHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
  ..  |.|.|| .| ||.|| ..   .|  . ..  .||  .. .||..| |.. .  || .||. |. ..
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1010-1246 2e-23 77.7 In-house 36-295 (297) alignment 
Range on Protein: 1010-1246
Range on HMM: 36-295/297.0
KNHDPNFLPYDDNRVRLTPCRDNRhGYVNASSISATVGTKQRFYIVAQSPQEpLTMRIFWQCVWEADVY---LVVQLTED-----MSYIPRNSHQRLEFG
||   . | .||.||.|     .|  |.||  .      ..  ||.|| | .  |.  ||. |.| ||    .| .| ||     . | |.   .||. |
knryrdilatddtrvkllrviter.dyinadyvvfpdeeadlkyilaqGpls.atvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkag

QFQVyQEFSQTTDRCTT---IKLRLYHVpsRRYRSVWYLQYADWAEQNCP---RDVNHF--------------LDFLEELNSVRLASTQEVPPGHNTNPP
.. | .  |.|.|   .    .|.|..    . | | . |.  | .   |    |.. |              |  .| . .. .   . .   .  | .
dvvv.eflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnay

VLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
.|.||  | ||||| . .| .|  | ..   |.  .. .||.||  .. .| |....|.. .  |
llvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1005-1244 5.4e-23 76.1 In-house 46-277 (439) alignment 
Range on Protein: 1005-1244
Range on HMM: 46-277/439.0
EENEPKNHDPNFLPYDDNRVRL--TPCRDNRHgYVNASSISATVgtKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLT---EDMSYIPrnSHQRLE
| ...||.  .  ..|  || |  .|     | |.||  |      ....|| .| |..  |   ||. |.|  .  .|.||   | . | |  | .   
eydqtknrykdvgafdhtrvtlqeipgvphsh.yinanyikGyy..ddklyiatqgpkke.ttddfwrlviekktvtivmltnlvesykywp..sdaevc

FGQFQVYQEFSQTTDRCTTIKLRLYH--VPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlaSTQEVppghntnPPVLLHCLEGGGRSGVTL
.|.  |  .      . .   ....     ... |.|  ..|  | ..| | .  | ||||  .||     ..|.        ||..||  | ||.|  .
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan..dkeey.......gpvvvhcsagvGrtGtii

TADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLIT
. |. |  |  .. .||  ..  ||.||  .. .|.|| |||| .. 
aldialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
0043147 (Phosphotyrosine protein) phosphatases II 1031-1239 1.5e-22 75.6 In-house 2-154 (172) alignment 
Range on Protein: 1031-1239
Range on HMM: 2-154/172.0
DNRHGYVNASSISATVGTKQrfYIVAQSPqEPLTMRIFWQCVWEADVYLVVQLTEDmsyiprnshqrlefgqfqvyqefsqttdrcttiklrlYHVPSRR
|... |.||| .. .. ...  .|. | |  . |.  ||. ..| .. ..| |||                                      .. |.  
degsdyinasyldlyyipdr..fiatqgp.lrntladfwrmlkelgithivnltel.....................................lydpell

YRSVWYLQYADWAEQNCPrDVNHFLDFLEELNS--VRLAstqevppghntNPPVLLHCLEGGGRSGVTLTADLLLytldhnEDLDIPRVIGQLRHQRDSI
.|... ..|  |  ...| . ...|.||| ...  ..             . ||| ||  | ||.|.   |.|.|      ..|..  .. ..|..|  .
erlgiqylylpwpDhgvp.llellleflefidellalsp...........ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpga

IPSLAQYKFIY
...  ||.|.|
vqnpsqyrfly
0036282 (Phosphotyrosine protein) phosphatases II 1035-1240 1.8e-22 75.3 In-house 3-164 (174) alignment 
Range on Protein: 1035-1240
Range on HMM: 3-164/174.0
GYVNASSISATVGTKqrFYIVAQSPQEpltmriFWQCVWEADVYLVVQLTEDMSY--------IPRnshqrlefgqfqvyqefsqttdrcttiklrlyhV
 | ||| .. .. |.   .|. | | .      ||. ..| ..  ||.|.| .           |.                                  
dyinaspldlsyitp..rliagqgpla......fwemlkelgittvvmlleekelglykcinywpe.................................l

PSRRYRSVWYLQYADWAEQNCPRDVNhFLDFLEELNSVRLAstqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDhNEDLDIPRVIGQLRHQRD
..  .|... ..|  |   ..| .   .|.|.........          . . ||| ||  | ||.|.   |.|.|. |  .   |. ... .|| || 
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.........dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrp

SIIPSLAQYKFIYN
 ....  ||.|.| 
gmvqtpsQyrflyy
0041856 (Phosphotyrosine protein) phosphatases II 1007-1246 2.3e-22 74.9 In-house 1-171 (182) alignment 
Range on Protein: 1007-1246
Range on HMM: 1-171/182.0
NEPKNHDPNFLPYDDNRvrltpcrdnRHGYVNASSISATVGTKQrfYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTeDMSYIPrnshqrlefgqfqvy
| .||  ...|||| .|            |.||. .     ...  .|..| |    |.  |.. ..| .. ..| || .  | |               
nldknrysdilpydhsr.........dldyInanlylgslpatr..fiatqgplls.tvadflrmlkelgittivnlt.eelywp...............

qefsqttdrcttiklrlyhvpSRRYRSVWYLQYADWAEQNCPRdVNHFLDFLEELNSvrlastqevppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTl
                     .. .| .. ..|  |   ..|  ....|||.|| ..               . ||| ||  | ||.|.   |.|...  
.....................ellerlgiqylylpwpDhgvpd.ldelldfieevle..............eggpvlVHCsaGvgRtgtlvaaylmkkl.

dhneDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
    ..... .. ..| .|  .. .. || |.. .|  .|
....gvsleeavklvrsrRpgmvitpnqyfflqlallell
0049772 (Phosphotyrosine protein) phosphatases II 1001-1248 3e-22 75.2 In-house 40-282 (314) alignment 
Range on Protein: 1001-1248
Range on HMM: 40-282/314.0
CALLEENEPKNHDPNFLPYDdNRVRLTPCRDNRHGYVNASSISATvgtkqRFYIVAQSPqEPLTMRIF----------WQCV--WEADVYLVVQ------
 | |..|  ||  ...||.| |||.|     . ..| ||| ..       . .|..| |  . |.  |          |. |  .. .|  .|       
vadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgp.leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LTEDMSYIprNSHQRLEFGQFQvyqefsqttdrcttiklRLYHVPSRRYRSVWYLQYADWAEQNCPrDVNHFLDFLEELNSVrla
               |.. . .   |     .. ...                 . .. |..  | .  . . ..   ..| . ..|..||| ....   
adelsrLdaAlgKtpllildgng..neptaadlellk.................eelydpelferlgikylripvpDgsap.lledfdeflefieea...

StqevppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLdhneDLDIPRVIGQLRHQRD-----SIIPSLAQYKFIYNLLITYLKR
.         .. ||| ||  | ||.|. ..|..|.. |    ....  .. ..| .|      . |..| || ||.. |  |||.
d.........kggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkf
FERM_M FERM central domain 114-230 9.3e-22 67.7 Pfam-A 4-126 (126) alignment 
Range on Protein: 114-230
Range on HMM: 4-126/126.0
HLSDEATRFYYFLQLKSDIYEGRIACDIRTAILLALYCRQAEYDSYQ-GDKQSKDYLKKSLV-------LPrnMQGLANDDSMLEGLIVEVLQQQAGIAH
...||... ....|.|.|..|.|. |.  .|.||| .  |.|.. ..  .|.|...|.|..        ||  ..   .  .  . |  ..|.. . .| 
pkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllp..vsprllkkekskqleqrileahknvag

LSQSQAEEMYIQCCQQLEGYGEERF
||...|. .|.|..|.|..|| . |
lslaeaklkylqaaqslpdyGvslF
PTPc_DSPc_SM00012 1134-1242 1e-21 72.5 In-house 2-103 (105) alignment 
Range on Protein: 1134-1242
Range on HMM: 2-103/105.0
VWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQevppghntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHN-EDLDIPRVIGQLRHQRDSIIPSL
|  ..| .| ....|......|..|....... .|..        ..||..||  | ||.|.  ..|.||  |... . .|| ... .||.|| . . ..
vkhyhytgwpdhgvPeesdsilellravkknknkses........skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte

AQYKFIYNLL
.|| |.|. |
eqylflyral
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 981-1244 2.4e-21 70.6 In-house 20-234 (392) alignment 
Range on Protein: 981-1244
Range on HMM: 20-234/392.0
SQLFMEFERIPKRREhALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYL
. .| ||  .|         .|  | | .||   | |||| .||.|    |   . |.||| | .     .. || .|.|. . ..  ||. |.. .|  
alffeefhdlpgpdi.ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsf..dnekayiasqgpn.aaslddfwrmvfqenvtt

VVQLTE----DmsyiprnshqrlefgqfqvyqefsqttdrcttiklrlyhvPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvRLastqevppG
.. .|.    |                                            .|.|   ....| ... |. .. .| |..|...           |
iamvtklkegd........................................kgddartvaqfhftewPdkdvpkhtssllkfikevka.df........G

HNTNpPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLIT
. |  |...||  | ||.|| .. | ..    .   .|.  .. ..|..|  .. .  || |||  .. 
qyth.pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
FERM_N FERM N-terminal domain 26-108 1.5e-20 63.3 Pfam-A 2-80 (80) alignment 
Range on Protein: 26-108
Range on HMM: 2-80/80.0
HLLDTSsTVDCTISSESKGQECLDNVCQRLLIQQPEFFGLRYlvkGKDKEDEFKWIDLERSLSRQLEKYAAGPKIYLRVRHYV
.||| . ....|......|...|..||.|| ... |.|||..    .||..|..|.|....|..|...  .  ...|||..||
rlLDgt.vkevtvddsktgavlletVckrlglteteyFgLaf...kedkknesnwLdhdktlreqgveegkpttlllrvkfyv
subfamily_eak_pd Subfamily eak 1016-1248 1.9e-19 64.2 In-house 60-307 (332) alignment 
Range on Protein: 1016-1248
Range on HMM: 60-307/332.0
FLPYDDNRVRLTPCRDNRHGYVNASSIS-ATVGTKqrfYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVY
 .||| . ||||... || ||.||| .  . || |   ||..  ..|   . .||| | |     .||| ||.         | | .... |.||...| 
ivpydrylvrltssqlnrlGyinaslaefsevGrk...yiltGiased.kvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve

Q-EFsqtTDRcTTIKLRLYHVPS-RRYRSVWYLQYADWAEQNCPRdVNHFLDF---LEELNSVRLASTQEV------PPGHNTNPP--VLLHCLEGGGRS
. ||     |   .. ||. .        | . ..  |.| . |. .. || .   . |   . |. ...          . | |    .. .  |. |.
rkef...vkr.niletrllelskGnethrvlhykvfGwtettlpk.yedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsara

GVTLTADLLLYTLDHN--EDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
|| .  |||.  .| .  .   .  .| . ...|   ..   |. |||.... ||.|
Gvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
0046846 (Phosphotyrosine protein) phosphatases II 1052-1247 1.4e-18 62.8 In-house 24-174 (176) alignment 
Range on Protein: 1052-1247
Range on HMM: 24-174/176.0
FYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTED--------MSYIPRnsHQR--LefgqfqvyqefsqttdrcttiklrlyhvpsrryrsvwYLQYAD
..|. | | .  |.  |.. ..|.....|| |||.        . | |.   ..  .                                       .. .
rpiatqgplpr.tladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi.....................................qylhlp

WAEQNCPRDvNHFLDFLEELNSVRlastqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYtldhNEDLDIPRVIGQLRHQRD-SIIPSLAQYKFIYN
| . ..| . ...|..||......           . . ||| ||  | ||.|. . |.|| .    . .|..  .. ..| ||   .... .||.|.| 
wpDhgvpdl.elllellefireal...........keggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflye

LLITYLK
 .  .||
fellllk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 976-1248 4.9e-18 59.6 In-house 21-287 (302) alignment 
Range on Protein: 976-1248
Range on HMM: 21-287/302.0
QKLSDSQLFMEFERIPKRREHaLYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNrhgYVNASSIsaTVGTKQRFYIVAQSPQEPLT--MRIFWQCVW
..|  ...  ||..| . . . | .| .  .|  ||. ...  .|.|.|.|. . |.   |||||..  .|   .|  |.|| |.   .  .  ||. |.
ksldtaevkkefkkidtmkvd.lekCkafkknlkknqsedvpildsnlvkleaepds...yvnaskv..evPeltrsiilaQlpkvdsedsveeFWrmvf

EADVYLVVQ--LTEDM-----SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTtIKLRLYHVPSRRYRSVWYLQ--YADWAEQNCPRDVNHFLdflEELNSV
.  .  ||    .|..      ..|..| . .|.|.. | .   . ..  .  .. .  .|     ||         | ... |  ...     ..  .|
qekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeli...ktaakv

rLASTqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR
  |..       ... ....   .| || |. ||. . . .|.....  |  .. ..| || ... || || ..|  |..|.|.
.fakk......ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
0044763 (Phosphotyrosine protein) phosphatases II 1018-1246 7e-18 60.3 In-house 1-171 (178) alignment 
Range on Protein: 1018-1246
Range on HMM: 1-171/178.0
PYDDNRVRLTPCRD-NRHGYVNASSISatvgtkQRFYIVAQSPqepltmRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHqrlefgqfqvyqe
|.|..|| |.. .. .|  | ||| |        ..|. .. |        ... ..| .. ..| |||..         | |.. .             
pldrtrvllsnleglersdyinaseil......pglylgslpp......addlellkelgithivnlteelelgflkcdpywpeeag.............

fsqttdrcttiklrlyhvpsrryrsvWYLQYADWAEQNCPRDVNHFLDFLEELNSVRlastqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLYTldh
                          .  ..  .   ..|    |||.|.| .....          .. . ||| ||  | ||||.   |.|...    
..........................iqylhipipDhgvpdllehflefvefieeal..........dekggpvlVHCsaGvgRsgtlvaaylmkkl...

neDLDIPRVIGQLRHQRDsIIPSLAQYKFIYNLLITYL
  .|... .| ..| .|  |.|.  |....| .   .|
..glsleeaielvrerRp.ivpnpgqlrqLyefelrll
0048076 (Phosphotyrosine protein) phosphatases II 1095-1243 1.5e-17 59.0 In-house 8-140 (145) alignment 
Range on Protein: 1095-1243
Range on HMM: 8-140/145.0
HQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLAstqevppghntNPPVLLHCLEGGGRSG
 ..| .| . . ... .  |   |  |.| . ..  .| .. ..| .|   ..| . ...|.||| ..... .           . ||| ||  | ||.|
lpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...........ggpvlVHCsaGvgRtg

VTLTADLLLYtldhnEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI
.   |.|.|.     ...... .. ..| ||  ..|.  |..|.| .. 
tlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 999-1247 1.7e-17 58.1 In-house 32-294 (301) alignment 
Range on Protein: 999-1247
Range on HMM: 32-294/301.0
YECALLEENEPKNHDPNFLPYDDNRVRLTPCRD---NRHGYVNASSISATVgtKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTED--------M
 .  | |||.. |.  |  .|||||. |.| ..    .. |.||| |...   ... .|.||.| .  |.. ||. .|.  .  .| .|.          
ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys..ekkkfiaaqgpmkk.tlvdfWrliwqekpvsivmvtnlkegtkskce

SYIPRNSHQRLEFGQFQVYQEFSQT----TDRCT----------TIKLRLYHVPSR-RYRSVWYLQYADWAEQNCPRDVNHFLDFLEELnsvrLASTQEV
 | |. .... |||.|.|    .|.    . |            .   | ..| |.   ..|  || .|| ..   |. .  |  ...     .  .| .
qywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddv....ihrqqki

PPGhntnpPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
  |     ||. || .. .||||  . .. |     .   |.  |.  .|...   .  | || .||. . .||.
ggg.....pvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 982-1246 2e-17 58.1 In-house 7-259 (267) alignment 
Range on Protein: 982-1246
Range on HMM: 7-259/267.0
QLFMEFERIPKRREH-ALYECALLEENEPKNHDPNFLPYDDNRVRLtpcRDNRHGYVNASSISATvgTKQRFYIVAQSPQEpLTMRIFWQCVWEADVYLV
..  ||| | |  .  .   . . |.|. .|.  . |||||.|| |   |.. . |.||| . .    ... .|| | | .  |.  |.. . . .|  .
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvil...rtkeeeyinasyvegy..ktknafivtqdplk.ntitdfltvihdqkvpvi

VQLTEDMS-YIP----RNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRyRSVWYLQYADWAEQNcprDVNhflDFLEELNSVrLASTQEvppg
| ||      |.     .  |  .. .. | . . .  .    | | |        . |    |  |  .    . .    .|. |  . ||  |     
vlltkvftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnint...nnk...pylkplfgi.laknql....

HNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
 | |.|....| .| ||||  |..|  |  . ... .||   . ..|.|| ... .. .| .|..||  | 
engnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1006-1241 6.3e-17 56.6 In-house 2-234 (237) alignment 
Range on Protein: 1006-1241
Range on HMM: 2-234/237.0
ENEPKNHDPNFLPYDDNRVRLTPCRDNrHGYVNASSISATVGTKQRfYIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM--------SYIPrNSHQR
||. ||.  |   || .|| |  .  .   |.||. .    || .. || || | |. .   ||| ||.    ..| ||  .         | | ...| 
enkiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkk.yiaaqgples.scddfwqmvwqekcsvivmltgliegnelkchkywp.stdqp

LEFGQFQVY----QEFSQTTDRCTTIKLRLYHVpsrRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELnsvrLASTQEVPpghnTNPPVLLHCLEGGGRS
  .|.. |     .|||. | |. ..  ||        | ..  |.. | ..  |.    .| |  ..    .  .. |.       | ..||  | ||.
aaygvltvslkkkeefsdytvrslllskrltlk...evrlihqyqftswpdrgvpqqtaallrfrkni....inrsphvs....esgpwiihcsagvgrt

GVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNL
|. |  | .|     .. .||   .  .  .|  || .  || ||.. 
giflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt
0051082 (Phosphotyrosine protein) phosphatases II 1035-1240 9.5e-17 56.5 In-house 4-147 (151) alignment 
Range on Protein: 1035-1240
Range on HMM: 4-147/151.0
GYVNASSISATvgtkqrfYIVAQSPqepltMRIFWQCVWEADVYLVVQLTEDM------SYIPRNShqrlefgqfqvyqefsqttdrcttiklrlyhvps
.| |.| .          ... . |     .  |.. ..| ... .| |....      .| |...                                  
dyinfsyvtgg.......lyrsggp.....ladflellkelgiktivnlrseeergycpeylpelg..................................

rryRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlastqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTldhnedLDIPRVIGQLRHQRDSI
   . |..... || ....|   . .|.|||.|..             . | ||| ||  | ||.|.   ..|.|.       ...  .. ..| .|  .
...ievlhipildwpdpglplsfdavleflellld.............kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgv

IPSLAQYKFIYN
. .  |. |.. 
vqpnqqflfqlf
0049260 (Phosphotyrosine protein) phosphatases II 1061-1240 1.8e-15 52.4 In-house 18-144 (152) alignment 
Range on Protein: 1061-1240
Range on HMM: 18-144/152.0
EPLTMRIFWQCVWEADVYLVVQLTEDMSYIPRNSHQRLefgqfqvyqefsqttdrcttiklrlyhvpsrryrsvwYLQYADWAEQNCPRDVNHFLDFLEE
 | |.  ||. ..| ..  .| |||..       .|                                         ..  |   ..| .  ..|..|. 
gpntladfwrmlkelgittivmltellelgklkceqyi.....................................qylhlpwpDhgvpdlsqlllflllf

LNSVRLASTQevppghntnpPVLLHCLEGGGRSGVTLTADLLLytldhnEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYN
..  .| .            ||| ||  | ||.|.   |.|.|       ....  .. ..| .|  ..|.  |..|.|.
ieklaldkgg..........pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1008-1247 7.9e-15 49.6 In-house 55-272 (288) alignment 
Range on Protein: 1008-1247
Range on HMM: 55-272/288.0
EpknhdpnflpyDDNRVRLTpcrDNRHGYVNASSISATvgTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTE--------DMSYIPRNSHQRLE
            |  ||.|.   |. . |..|  .|..    .|  | ||.|    |. ..|. . |.||  .| |.|           | | .  ..  
c...........ditrvkls...ddpdfyiaanvvssa..kykrrlicaqaPl.ngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FGQFQVYQEFSQtTDRCTTIKLRLYHV--PSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELnsvrlastqevppgHNTNPPVLLHCLEGGGRSGVTL
.|..      .. .|   ..|. | ..  .      | .| . .| ..  | .   .| .|| |              .... |...|. .| ||.|   
igrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..............kslqkPivvhssaGvGrtgtli

TADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
   . | .|  ...| |.... .|| .|   | .  || ... ..  .| 
lilialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
0048179 (Phosphotyrosine protein) phosphatases II 1118-1240 1.3e-14 49.7 In-house 33-139 (144) alignment 
Range on Protein: 1118-1240
Range on HMM: 33-139/144.0
TIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVrlastqevppgHNTNPPVLLHCLEGGGRSGVTLTADLLLytldhNEDLDIPRV
 | |.  . |    | .. ... .|   ..| . ...|.||| ....           .. . ||| ||  | ||.|.  .|.|..      ..|..  .
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieea...........leeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleea

IGQLRHQRDSIIPSLAQYKFIYN
. ..| .|  ..|.  |..|...
lalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 976-1245 2.1e-14 47.9 In-house 6-268 (281) alignment 
Range on Protein: 976-1245
Range on HMM: 6-268/281.0
QKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTP--CRDNRHGYVNASSISATVgtKQRFYIVAQSPQEPlTMRIFWQCVW
||..  ..  ||  .|      |  .     |. ||.  |    |  ||.|       |   |. |  | . .   .| ||..| |..  |   ||. .|
qkmtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf..lkrgyiltqgpkke.tradfwrmiw

EADVY---LVVQLTED-----MSYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYlqYADWAEQNCPRDVNHFLDFLEelnSVR
. .     ...|..|        |.|||.|  |.| .. |  | |       | .| | .    |  . |   . .| . . |   . .|  |     .|
qenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwl..wkewpdwqvpessevmlkilr...kir

LASTqevppghntnPPVlLHCLEGGGRSGVTLTADLLLYTLD-HNEDLDIPRVIGQLRH-QRDSIIPSLAQYKFIYNLLITY
  ||          ||| .||  | ||||  .. .. | ..  |    || ... .||   | . . .| || .|...|. .
arst..........ppv.ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
FERM_C FERM C-terminal PH-like domain 236-317 6.4e-14 42.3 Pfam-A 3-85 (90) alignment 
Range on Protein: 236-317
Range on HMM: 3-85/90.0
LGNDLLLGLAINGMVVNADNGRQ---YFPWKEFHTVTIDKRTIKIEQNKldGGGSIVGSFIFSEADTARYFWKLTISQHKFFKRY
 |.|||||.. .|. .  .| .     |||.| . .. ..... |....     . | .| .|.........|| |..|..|.| 
kgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd..ekkkdvlkFyssqlrvnklllklcienhdlfrrr
subfamily_CG42327_pd Subfamily CG42327 1178-1247 4.7e-12 40.2 In-house 246-316 (319) alignment 
Range on Protein: 1178-1247
Range on HMM: 246-316/319.0
TNPPVLLHCLEGGGRSGVTLTADLLLYTLDHN-EDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
 . |. .|| .| ||.|. ...|. . .|... . .|||... ..|..| | . .  ||.|||. |  | |
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1049-1240 6.7e-12 40.0 In-house 3-198 (199) alignment 
Range on Protein: 1049-1240
Range on HMM: 3-198/199.0
KQRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLY--HVPSRRYRSVWYLQ
 || ||..| |    ||  ||| |||.    .| . .|          | |       ..| . |  .   |    |   | |          | . . |
gqrryiatqhplr.etmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YADWAEQNCPrDVNHFLDFLEELNSVRLASTQEvppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHN--EDLDIPRVIGQLRHQRDSIIPSLAQYK
.. | |.  | .|  |. |.     |     ||       . ||..|| .| | .|| .. |. . . .      .|.  |  .||  |  || || .|.
ftswkekttp.nvalfvgfvvasrevskkyeqe......kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn

FIYN
|||.
fiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1050-1240 1.1e-11 39.2 In-house 3-197 (198) alignment 
Range on Protein: 1050-1240
Range on HMM: 3-197/198.0
QRFYIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLY--HVPSRRYRSVWYLQY
|| ||..| |    |.  ||| |||.    .| . .|          | |       ..| . |  .   |    |   | |          | . . |.
qrryiatqhplr.etladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

ADWAEQNCPrDVNHFLDFLEELNSVRLASTQEvppghnTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHN--EDLDIPRVIGQLRHQRDSIIPSLAQYKF
. | |.  | .|  |. |.     |     ||       . ||..|| .| | .|| .. |. . . .      .|.  |  .||  |  || || .|.|
tswkekttp.nvalfvgfvvasrevskkyeqe......kdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

IYN
||.
iyq
subfamily_ptpA1_pd Subfamily ptpA1 1007-1209 2.6e-11 37.9 In-house 47-259 (418) alignment 
Range on Protein: 1007-1209
Range on HMM: 47-259/418.0
NEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISatvGTKQRFYIVAQSPQePLTMRIFWQCVWEADVYLVVQLTEDMSY----IPRNSHQRLEFG
|  ||.  | || .  ||.|   .|.    |.||  |    |.  . .|..| |  | |.  ||. |||  . ..| |. .         |   ...   
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid...gaypkqfictqgpl.pntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge

QFQVYQEFSQ--------------TTDRC-TTIKLRLYHvpSRRYRSVWYLQYADWAEQNCPRDVNHFLDFleeLNSVRLASTQEVpPGHNTNPPVLLHC
|| .| .  .                .|   | ..||        | .   ||  | ..| |   . | ..   | |.     | . |  . | |...||
qfsiygngnevfgtysvelveviqdpereiitrnirltf..egetrditqyqyegwpdhnipdhtqpfrql...lhsitnrqnqii.pssdrnvpiivhc

LEGGGRSGVTLTADLLLYTLDHN
  | ||.|   || ...  ||| 
sagvgrtgtfctavimmkkldhy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1006-1239 7.8e-10 33.3 In-house 7-234 (239) alignment 
Range on Protein: 1006-1239
Range on HMM: 7-234/239.0
ENEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATVGTKqRFYIVAQSPQEPLTmRIFWQCVWEADVYLVVQLTEDMSYIPRNSHQRLEFGQfQ
 |. ||.  | . || .|| |    ..    |.||| .    |.  . || .|   |. .   ||. .|.    ..| ||  .    .. ||        
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp.kayiatqgcveiss.gdfwrmmwqerrcvivmltglieghkkkchqywpdst.s

VYQEFSQT---TDRCTTIKLR---LYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLdfleelnSVRLASTQEVPPGHNtnpPVLLHCLEGGGRSGVTLT
 | ..  |   |.  .   .|   . .|     | |.  ... | ..  |.     |        .|   |..  ||     | ..||  | ||.|  | 
kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavl.......glrrkitkdslpgar...pwvihcsagvgrtgaflv

ADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIY
 | .|    ... .||   .  .| .|  .. .  || ||.
idamlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1007-1239 1e-09 32.9 In-house 7-233 (239) alignment 
Range on Protein: 1007-1239
Range on HMM: 7-233/239.0
NEPKNHDPNFLPYDDNRVRLTPCRDNR-HGYVNASSISATVGTKqRFYIVAQSPQEPLTmRIFWQCVWEADVYLVVQLTEDMSYIPRNSHQRLEFGQfQV
|. ||.  | . || .|| |    ..    |.||| .    |.  . || .|   |. .   ||. .|.    ..| ||  .    .. ||         
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp.kayiatqgcveiss.gdfwrmmwqerrcvivmltglieghkkkchqywpdst.sk

YQEFSQT---TDRCTTIKLR---LYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLdfleelnSVRLASTQEVPPGHNtnpPVLLHCLEGGGRSGVTLTA
| ..  |   |.  .   .|   . .|     | |.  ... | ..  |.     |        .|   |..  ||     | ..||  | ||.|  |  
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavl.......glrrkitkdslpgar...pwvihcsagvgrtgaflvi

DLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIY
| .|    ... .||   .  .| .|  .. .  || ||.
damlrqakkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 982-1246 2.4e-09 31.6 In-house 17-277 (307) alignment 
Range on Protein: 982-1246
Range on HMM: 17-277/307.0
QLFMEFERIPKRREHALYECAlLEENEPKNHDPNFLPYDDNRVRLTpCRDNRHGYVNASSISATvgTKQRFYIVAQSPQEPlTMRIFWQCVWEADVYLVV
.|  ||. . |.  ...   | .. |  ||   .    | .|. ..        |. |  .  .  .| . .|.|| |.|  |.  ||  . . .|  |.
alvdefrvlakktpegvtvea.fsantdknryqdvkcqdkgrivvk.fdglasdyihanylgia..ikpkkficaqgplen.tqysfwamaiqekvesvi

QLTEDM--SYIPRNSHQRLEFGQFQVYQEFSQTTDRCtTIKLRlYHVPSRRYRSVWYLQyADWAEQNcpRDVNHF--LDFLE-ELNSVRLASTQEVPPGH
 | . .  . |  . .  || || .|. | ..|      .  .    |   .  |  |.  |||...  | ..|.   .. .     . |..   .   .
mlckvielakikceqywpleegqklvfgeapntisva.nlgak.klapdedlinvttlk.vdwaqks..rtiqhlqwenwpdrgvpqinltainlleavr

NTNPPVLLHCLEGGGRSGVTLTADLLLYTL-DHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
  . ||..||  | ||||  ..  |.   . .  .  |. ... .|| ||.  | . ||| ... .|. |.
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1009-1090 2.4e-09 31.4 In-house 49-142 (350) alignment 
Range on Protein: 1009-1090
Range on HMM: 49-142/350.0
PKNHDPNFLPYDDNRVRLT----PCRDNRH-----GYVNASSISAT---VGTKQRF-YIVAQSPQePLTMRIFWQCVWEADVYLVVQLTEDMSYI
 ||   | |||. .||.|     .    .|      |.||. .. |   |  .  | || .|.|  | |.  |.... . .| ... ||.|. . 
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPl.pstvddfykvillnkvkvilsltsdveln
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1050-1243 2.8e-09 30.8 In-house 235-435 (440) alignment 
Range on Protein: 1050-1243
Range on HMM: 235-435/440.0
QRFYIVAQSPQEPlTMRIFWQCVWEADVYLV---VQLTEDMS--YIPRNSHqRLEFGQFQVYQEFSQTTDRCTTIKLRL-YHVPSRRYRSVWYLQYADW-
.  .| .| | .  |.  ||. | .  .  .    || .     | | |.   . || | | .  |.  .|     | | |.      |      .  | 
knafiatqmplds.tvldfwrlvhdyristiimlnqlndktcsiywpvntr.svtfgpftvghkgsenmnrvkvrtlelkykeevheirqfevqtwptwi

------AEQNCPRDVNHFLDFLEELNSVRlaSTQEVPPGHntNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYK
      ....|   |  ..|.|.  .  |  ||..  ||    ||.|.||| |   |||  |    |  |. .  .|. . .  ||  |  ..|.|..| 
qsdgvqsqeqcmdavlqlmdylrkceiqr..steqsrpgd..gppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyl

FIYNLLI
. |.|| 
lcykllt
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1044-1234 3.5e-08 27.5 In-house 84-269 (301) alignment 
Range on Protein: 1044-1234
Range on HMM: 84-269/301.0
ATVGTKQRFyIVAQSPQEpLTMRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSR---RYR
 | |  .|| |..|.| .  |.  ||  .   ||  .| |.. .        .|.| . ...|. |.|..  . ...  .  ..| .|  . |      |
ptsGhphrf.iatqgPlk.ntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatr

SVWYLQYADWAEQNCPRDVNHFLDFLEELNsvrlastqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSL
.| . ||..|.... |.   .  |..| .               ... |...|| .| |||   .... |   .. .  ... . . .||..| . .   
tvthyqysewtdrgvPkshaelfdlmelvk..............ksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn

AQ
 |
sq
subfamily_CG42327_pd Subfamily CG42327 982-1163 7.8e-08 26.3 In-house 6-192 (319) alignment 
Range on Protein: 982-1163
Range on HMM: 6-192/319.0
QLFMEFERIPKRREHALyecALLEENEPKNHDPNFLPYDDNRVRLTPC-RDNRHGYVNASSISATVGtKQRFYIVAQSPQEPLTmRIFWQCVWEADVYLV
... ||. .|.   .|    ..    ..|..  | .|  . || |     |..  |..|| .       . .|| || . |  .   ||. |||     .
dvaeefrdlPqliarad...evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydd.apnsyiaaqvsledss.sdfwrtvweqqsrvi

VQLTEDM--------SYIPRNS--HQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYaDWAEQNCPRDVNHFLDFLEELNS
||||.           |.| .    ..  .|...|     .. ||  .  | | .|     | . .  | .| | . | . . ..  | | .|
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1020-1246 9.2e-08 26.1 In-house 68-289 (305) alignment 
Range on Protein: 1020-1246
Range on HMM: 68-289/305.0
DDNRVRLTPCRdnRHGYVNASSISATVGTKQRFyIVAQSPQEPlTMRIFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEFSQ
| . |.|         |. |  . . .  ..|| |.|| | .  |.  ||  | .  |  .| |   .         | |    ..||.    | .. | 
dqsavkldkps..psdyihanyvgcpmipekrf.icaqgpldq.tidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsg

--TTDRCTTIKLRLYHVPS--RRYRSVWYLQYADWAEQNCPRdvnHFLDFLEELNSVRlastqevppghNTNPPVLLHCLEGGGRSGVTLTADLLLYTLD
    .| . |.. | ..     .  || .||...| ..  |      |  || | ..|            .. |...||  | ||.|  .. . .|  . 
skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvpp...ckltslellsair...........gskvpivvhcsagigrtgtivaieyilekia

HNEDL-DIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL
 | .   .| ..  || ||   | .  || ||. ... |.
enkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1018-1247 1.6e-07 25.3 In-house 67-284 (290) alignment 
Range on Protein: 1018-1247
Range on HMM: 67-284/290.0
PYDDNRVRLTPCRDNrhGYVNASSISatvGTKQRfYIVAQSPQEPLTMRiFWQCVWEADVYLVVQLTEDM--------SYIPRNSHQRLEFGQFQVYQEF
  |  || |    |    || |  .    |.|   .|..| . .  ..  .|. | . .|  .| | | .         | | .. . | ||.. |    
cndktrvilkdGydG..dyvhanyvk...Glkam.filtqGalkdtvid.iwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcse

SQTTDRCTTIK-LRLYHVPSRRYRSVWYLQYADWAEQNCPrdvNHFLDFLEELNSVRLASTqevppghntnpPVLLHCLEGGGRSGVTLTADLLLYTLDH
... |  .  | | . .. | .   . .|.   | ..  .   .  | .|  | ..| ||            || .||  | ||.|   . .  |  | .
eddkdaniikktlsvrdkdsGkehklkhlkikswpdksva...lstlallrtlrilrkasG...........pvvvhcsaGiGrtGtfvaievglqilld

NEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLK
  .||.  ..  ||. | . .    ||  . ..|. . |
GkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1010-1251 2e-07 25.0 In-house 51-292 (305) alignment 
Range on Protein: 1010-1251
Range on HMM: 51-292/305.0
KNHDPNFLPYDDNRVRLTPCrdNRHGYVNASSISATvgTKQRFYIVAQSPQEPLTMRIFWQCVWEA--DVYLVVQLTED-----MSYIPRNSHQRLEFGQ
||   .    |.|||.| .     | |. |  .|.   |. . .| .|.| |     ... |. .    .... .| |      . |.. . .. ||| .
knrykdvgcldnnrvklegp..wpheyihanyvstp..tnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

----FQVYQEFSQ------TTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEElnsVRlastqevppghNTNPPVLLHCLEGGGR
     .|  | |.       ..   |    .   |  . | |    . || ..  |   .  |..||.    |            .  |. .||  | ||
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellek...ar...........pskgpivvhcsagigr

SGVTLTADLLLYTLDHNEDL-DIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTRL
.|  .  . .|  |   . . |  ... ..| ||.  | . ||| |...... |... .|
tgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1134-1246 2e-07 25.0 In-house 217-344 (350) alignment 
Range on Protein: 1134-1246
Range on HMM: 217-344/350.0
VWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLY-------TLDHNEDLD--------IPRVI
|. ||.  | . .   . . .|  ||  | .    . |     .  .|.| ||  | || |. .| | ||        . .. . ||        |  ..
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

GQLRHQRDSIIPSLAQYKFIYNLLITYL
 .||.|| |.. .| |. |||. |  | 
nelrkqrismvqnldqfifiYeallfyf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1062-1245 7.2e-07 23.5 In-house 38-220 (255) alignment 
Range on Protein: 1062-1245
Range on HMM: 38-220/255.0
PLTMRIFWQCVWEADVYLVVQLTED--------MSYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNH
 ||.  |.| .  ..   || |..          ||.| .  ..| . . .|    | .     |... ..    .. . | . .|  | |.| |.. . 
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

FLDFLeelnsvRLAStqevppghNTnPPVLLHCLEGGGRSGVTLTADLLLY----TLDHNE--DLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITY
 |  |      ...         ..  .|..|| .|.|||     |.|.      .||  |  .||  ... .||..| . |.   |  |   .....
ilnil......kvvr........ds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
E_Pc_C Enhancer of Polycomb C-terminus 354-409 8.6e-07 15.0 Pfam-A 3-56 (230) alignment 
Range on Protein: 354-409
Range on HMM: 3-56/230.0
AAEQLQQHHQQQQHMQQQQ--QIQQQQMisSNISLATSANQMLgqSSSCLDLSNNNLH
 ||| ||| .|  .||.||  |.||.|.  .. | |..|.| |   |  ||    .  
taEqyqqHqeqLvlmqkqqlaqlqqkql..qqnssaatatqal..vsktlDsAsAqFA
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1133-1247 8.9e-07 22.5 In-house 219-345 (349) alignment 
Range on Protein: 1133-1247
Range on HMM: 219-345/349.0
SVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLY----TLDHNEDLDIP--------RVIGQ
 .. ||. .| .     .   .|  ||  | .      .     .  ...|.||  | ||.||  | ||||     . ..   ....         .. .
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRHQRDSIIPSLAQYKFIYNLLITYLK
|| || |..  |||. .||. |. |..
lrkqrismvqnlaqfiaiyealLkyfa
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1034-1245 2.3e-06 22.0 In-house 46-258 (290) alignment 
Range on Protein: 1034-1245
Range on HMM: 46-258/290.0
HGYVNASSISATVGTKqrfYIVAQSPQEPL------TMRIFWQCVWEADVYLVVQLTEDM------------SYIPRNSHQRLEFGQFQVYQEFSQTTDR
 .|. |. ..   | .    |. |||||        |.  ||  . .  |  ||.| | .             |.| .  . | |. ..|      . | 
ddyiHAnrvtcpnglr...liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekedd

CTTIKLRLYHVPSRRYrSVWYLQYADWAEQNCPRDVNHFLDFLEELNSvrlaS-TqevppghntnpPVLLHCLEGGGRSGVTLTADLLLYTLD-HNEDLD
  | .| . .   . .  |   .. .| . | ..|   .|. .. ..     | |           ||..|| .|  || .  . .|    .   .... 
vetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvka....skt...........pvivHcvdGiSrsAalaaiilgyQkiaetsgsvk

IPRVIGQLRHQRDSIIPSLAQYKFIYNLLITY
.  |. .||.||.  | |  .. |.   .. .
ledvlkalrkqralaitsalelafvdagivll
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 979-1057 4.3e-06 20.8 In-house 21-94 (95) alignment 
Range on Protein: 979-1057
Range on HMM: 21-94/95.0
SDSQLFMEFERIPKRrEHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNrhGYVNASSISATvgTKQRFYIVAQ
|| ..  ||  |.     | | .   | | |||   | .|||  || ||  ||    |.||  .     ...  || ||
sdqefdnefksismt.sgapytvgsseanipknrflnifpydatrvvlttkrds..dyinacfvdgy..arkncyiaaq