Gene mop in Drosophila melanogaster

Synonym: CG9311, Dmel\CG9311, sfv, Dmel_CG9311, mop

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN23
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP042_AA protein Get Run
DmelP042_AA_1512-1787 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN23_pd Subfamily PTPN23 1514-1798 2.5e-117 385.8 In-house 2-288 (288) alignment
Range on Protein: 1514-1798
Range on HMM: 2-288/288.0
LLENLHVKMLNGKTQLGAKWQELQQKLDKEaaANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDF
|.|.|..|||.|||.|..|..||.|| |||  |.|||..||||..||||| |.|||||.||||....||||||...|.||.|||.||..|.|...|.|||
lveelqrkmldgktaldkkfkeleqkqdke..arkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WSMIWSEKSRTVVCLHTPNELFDP----YWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAPA------QLLGV
|.|....||...|.|....||..|    |||.. .......|..||. .|.......|..|||....|||| ..|.|||..|.. |.||      |.|..
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqflde

AENALETHRQRCKAanapqsPLIMNCLTGSERSELVAIGVCAIIATqNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNAHNVLNKRG
.|.|.|......|.      ||...|..|..|....|. ..|.... .|...||..|.|.||...||.........|..|...||..|..||.|||
vesayeavqrkskt......PlvvhCsaGvgRtgvfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldkrG

BRO1 BRO1-like domain 8-388 3.2e-103 333.6 Pfam-A 1-375 (377) alignment
Range on Protein: 8-388
Range on HMM: 1-375/377.0
HMLWFALKSSPEGTSFAALKKYIAEFYHEDPEAYSKEVHALETLRNQAMHT---TKDGAPVMKRYYCQLHALQNRFPqlaDRGI-FTFKWKDLY-HSAVH
....  || . |     .|..|| | |.|....|......|..||..|...   ...|  ...||| ||..|..|||   || .  .|.|.| . ..  .
plislplKetkevdlskpLsdyIletygeesssyeddlaelnklRqaavtpssrdesglelllrYyaqLellekrfp...drslkveFtWydafdtgspl

EVTDLRFERAAVLFNIAALHTQSGASVTRGDVDGMKMACTHFQAAAWAYGELRERYANVNGGgDfMTPELLVFQQQVCFAQAQECILEKSLIDNRKPHIV
....|.||.|.||||.|||..| .|| .| . .|.| |...||.||.|.  |.| . .     | ..||.| . .....||||||.|||.. |..| ...
aqrslafEkasvlFnlaalysqiaasqnrssdeglkaAvkyfqrAaGafeylkenflhapse.D.lspetlkvlvklmlAqAqecflekaildkkkdsli

AKVTAQIVVYYGAALAALLTGGDDGPvaqvidssVYKLWKKYVRFKINYLTCILYLYQGQHSEEKRQMGERVTLYQASWDKLEEARKESKGLPDQREINE
||..||.. .|  ||.|| .              . | |.|.| .| .|.... ..||....|||...||... .|.. ..|.||.|..|.. .. |..|
aklaaqvadlYeealealqesptktg........ipkewaklvqvKaeyfkAlahyyqalaleekkkyGeaiarLqeAlellkeaqklakkckskselle

SLSFTADVVEAKRKNAKNENEFIYHEAVPELSTIAAVQGANLVNGIGFQVSD--EEHAGPDIFARLVPMKAHEASSLYSEEKAKLLRK
.|... .....| ..|...|.|||.| ||. ... ....|.||. . ..  .  ... |.|.|..|||...|||.||||||||||.|.
dlkelkerikekleeaekdNdfiyleevpdeveltsikkaklvkalpinellsltkekgedlfkklvPiavheaaslyseekaklvrd

ALIX_LYPXL_bnd ALIX V-shaped domain binding to HIV 419-705 1.9e-60 192.6 Pfam-A 4-295 (296) alignment
Range on Protein: 419-705
Range on HMM: 4-295/296.0
ANKLPQGIVDRCAALNANkTAISDLVEAMSQLAEITADVETNLGEISSMLEAEAKAEREFQSATG--VQRTPNAHIT-ELSREFQKYSEAHARAGESNNT
 ..||. .......|...  .|..|.|....|.|  ..||. | |....|..|.. .....|  |   .|.| .. | || .| .|| ||.. | ||...
plglpesllekaeelrse.ggiesleeslddleelkqavesildeakeqLdeeesedeklrskygarwtrqpsseltaelreelrkyreaLeeAsesDsq

LRKAMSLHVNNLKILARPLPEIQQLMPKLS--SELNTTEIFRDVKLILNKVNEMKAQRAQFHADLRIAINEDDITGKVI--AHGGQEGLQALFATELGKH
||...  . ..|..|. |  |.....|. |  .. ...| ..... .|.|.|..||.||..  .|. .|..|||.  .|  .. ..  ...||..||.|.
lrskleeieedlalLsspeeeleaslpssspeesdevseqikrlrelleklnllkaeRaklleeLkekihdddiskilielnkksssneeqlfeeeLekf

DKITELLDQNMVAQGNILQALTENYAKAAPVlKTLQDVKQKREHFYSSLAASYDVYEDLLAKSAKGLEFYKKLAGNVQKLLTRFRSARDVQSEE
|. .| |.|.. .| ..|..|.| ... . . |. ...|..||.....|...||.|..| .. ..||.||..|. ....|... ..  . . .|
dplqerleqsiskQssllkelkeaneeflqd.kkskyekkerekvlqklenaydkykelssnleeglkFYndLlkileslrknvkdfvnarrsE

0050432 (Phosphotyrosine protein) phosphatases II 1496-1792 2.3e-48 160.5 In-house 16-301 (308) alignment
Range on Protein: 1496-1792
Range on HMM: 16-301/308.0
TDEKTTKYFQKEVESYEKLLENlhvkmLNGKTQLGAKWQELQQKLDkeaaANKRSTTIAKLFPEKNRSLDCLPYDHARVKLdKQTDDYINAAYMKNLS-A
 .. ......  |... ||||.     ......| . ..||... .     ...|..  .   .|||. |.||||| |||| ....||||| |..  |  
dtsilvsslklsvldllkllek.....aldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssk

GCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALD-QPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLK
    ||..| | |||..||| |.| ...|..|.| .. |     ...|||  |. ....|...|||.|....|...  ..|.|...| . .. .  .. .
lprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhyt

QWTK-GAPAQLLGVAENALETHRQRckaanaPQSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLC
 |   |.| ..  . .   . ....      |..| .  |  |  |.  ..  .. ..  | ..   ..  ... ..  || ..  .   ..  ....|.
nWpdhgvPpspeilldflelvrksl......pggpivVHCsaGvGRtGtfi..aldllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralle

NAHN
 ...
ylkl

0036941 (Phosphotyrosine protein) phosphatases II 1522-1806 3.1e-47 156.7 In-house 5-290 (297) alignment
Range on Protein: 1522-1806
Range on HMM: 5-290/297.0
MLNGKTQLGAKWQELqQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIWSEK
.|.....|  ...|  ..|..  .  ..|... .   ||||. |.||||| |||||.. .||||| |. ..   . .||..|.|.|||..||| |.| ..
llekllflalllkef.eellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvweqn

SRTVVCLHTPNEL----FDPYWPQALDQPTHYDDYTVTCLKVQQ--LSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCK
....|.| .. ||    ...|||   ...  |.|.|||.|.|..  |...  ..|.....| . .. .  .. . |    . .      . .|  |...|
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

AAnAPQSPLIMNCLTGSERSELVAIGVCAIIATQNK-QPILLNTIDVWSRICAQRQNSLRdsaILEQSMQIVLCNAHNVLNKRGIMTSYQMK
..  ...| .  |  |  ||  ...  ...   ..|     ..  ...  .  || ..      ||| ...  . .. ...|. ..  ....
ll.psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq...tleqyrflyeallellkkkltkepllklv

0047943 (Phosphotyrosine protein) phosphatases II 1523-1786 3.6e-46 153.2 In-house 8-268 (273) alignment
Range on Protein: 1523-1786
Range on HMM: 8-268/273.0
LNGKTQLGAKWQELQQKLDkeaaANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKS
|.|.|.| .....|..  .      ..|... .   .|||. |.||||| ||||. ...||||| |. ..    ..||..|.| |||..||| |.| ...
llgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrmvweqnv

RTVVCLHTPNEL----FDPYWPQALDQ-PTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAA
|..|.| .. ||    ...|||.  .. .. |...|||.|.... ...  ..|.|...| . ..    .. . |      . |    . .|  |. ..|.
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

NAPqSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIV
. . .| .  |  |  |.  ..  .. ..  | .    ..  ... ... || ..      ... ....
psn.gpvvVHCsaGvgRtgtfi..aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal

0051299 (Phosphotyrosine protein) phosphatases II 1509-1774 3.8e-46 153.2 In-house 5-270 (288) alignment
Range on Protein: 1509-1774
Range on HMM: 5-270/288.0
ESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKeaaaNKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMkNLSAGCPNFIVAQT
 |.|.||. .. ...||.|.| . ..||...| .    ...|... .   ||||. |.||||| ||||       ..||||| |. ..      ||..|.
isveellklvlkllangltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqg

PQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMH----GADAVLDLSLLQLKQWTKGAP
| |||..||| |.| ...|..|.| .. ||    ...|||.  .... |.|.|||.|....|...  ..|... .    | . ..    .. ..|     
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

AQLLGVAENALETHRQRCKaanAPQSPLIMNCLTGSERSELVAIGVCAIIATQNKqpILLNTIDVWSRICAQRQNSLR
 . .    . |.  |. ..   ....| .  |  |  |.  ...  ...   ...    ..  ... |.. || ..  
pdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvq

0046845 (Phosphotyrosine protein) phosphatases II 1530-1777 6.8e-45 149.0 In-house 3-261 (284) alignment
Range on Protein: 1530-1777
Range on HMM: 3-261/284.0
GAKWQELQQKLDKEAaaNKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK-----QTDDYINAAYMKNLS----AGCPNFIVAQTPQPNTINDFWSMIWSE
 ....||..   |     ..|.....   .|||. |.||||| ||||.      ...||||| |..  .      ...||..|.| |||..||| |.| .
eeefeellsltvkll..lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KSRTVVCLHTPNEL----FDPYWPQAlDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHG-ADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCK
..|..|.| .. |     ...|||.  ... .|.|.|||.|.... ...  . |.|...|  . .. .  .. ..|      . .    . |.. |. ..
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

AaNAPQSPLIMNCLTGSERSELVAIGVCAIIATQNKQ-PILLNTIDVWSRICAQRQNSLRDSA
. . ...| .  |  |  |.  ...  ...   .... .. ..  ....|.. || ..    .
n.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle

0040438 (Phosphotyrosine protein) phosphatases II 1524-1790 9.6e-45 148.6 In-house 15-276 (317) alignment
Range on Protein: 1524-1790
Range on HMM: 15-276/317.0
NGKTQLGAKWQELQQKldkeaA-AnKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIW
...|.|   ...|..           .|... .  ..|||. |.||||| ||||   .    .||||| |. .    ...||..|.|.|||..||| |.|
sdftalleefedllsl.....kld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntvedFwrmvw

SEKSRTVVCLHTPNEL----FDPYWPQalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRC
 ......|.| .. ||    ...|||.  .....|.|.|||.|....|...  ..|... .| . .. .  .. . |. . . . .    . ||  |. .
eqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

KaanAPQSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVLCNA
.    |..|..  |  |  |.  ..  .. ..  | ..   ..  ... .. .|| ..    . ... ....|.  
e...dpggpvlVHCsaGvgRtGtfi..aaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

Y_phosphatase Protein-tyrosine phosphatase 1559-1786 1e-44 148.1 Pfam-A 3-233 (235) alignment
Range on Protein: 1559-1786
Range on HMM: 3-233/235.0
EKNRSLDCLPYDHARVKL--DKQTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALDQPTHYDDY
.|||. |.||||. ||||  .... ||||| |.|. .    .||..| | ..||.||| |.| ||....|.| . .|     ...|||.. .....|.|.
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TVTCL-KVQ-QLSHCSEYQLKLSMHGAD-AVLDLSLLQLKQWT-KGAPAQLLGVAeNALETHRQRCkaaNAPQSPLIMNCLTGSERS-ELVAIGVCAIIA
.|..  |.. . ...  ..|.|. .... .   .. |....|. .|.|..  ..  . ..  ...    .| ..|..  | .|..|.  .||. ..   .
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll.dlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

TQNKQpilLNTIDVWSRICAQRQNSLRDSAILEQSMQIV
.....   ..  ...... .||...  . . ..  ....
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 1559-1786 1e-44 148.1 In-house 3-233 (235) alignment
Range on Protein: 1559-1786
Range on HMM: 3-233/235.0
EKNRSLDCLPYDHARVKL--DKQTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALDQPTHYDDY
.|||. |.||||. ||||  .... ||||| |.|. .    .||..| | ..||.||| |.| ||....|.| . .|     ...|||.. .....|.|.
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TVTCL-KVQ-QLSHCSEYQLKLSMHGAD-AVLDLSLLQLKQWT-KGAPAQLLGVAeNALETHRQRCkaaNAPQSPLIMNCLTGSERS-ELVAIGVCAIIA
.|..  |.. . ...  ..|.|. .... .   .. |....|. .|.|..  ..  . ..  ...    .| ..|..  | .|..|.  .||. ..   .
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespksll.dlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldilleql

TQNKQpilLNTIDVWSRICAQRQNSLRDSAILEQSMQIV
.....   ..  ...... .||...  . . ..  ....
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykai

0039614 (Phosphotyrosine protein) phosphatases II 1509-1783 4.3e-43 143.2 In-house 14-282 (297) alignment
Range on Protein: 1509-1783
Range on HMM: 14-282/297.0
ESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDkeaaaNkRSTTIAKLFPEKNRSLDCLPYDHARVKLDK-----QTDDYINAAYMKNLSAGCPNFIVAQ
.... |   |... .|.||.| . ..||..  .     . .|..  .   .|||. |.||||| ||||         .||||| |..  .  ...||..|
iplsvldlllllekansktllllefeellslkp.....d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatq

TPQPNTINDFWSMIWSEKSRTVVCLHTPNEL---FDPYWPQALDqptHYDDYTVTCLKVQQLSHCSEYQLKLSMhgADAVLDLSLLQLKQWTKGAPAQLL
.|.|.|..||| |.| ......|.| ...||   ...|||.  .    |.|.|||.|||..|...  ..|....   . .. .  .|   |  . . ..|
gPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppsl

GVAENALETHRQRCKAAnAPQSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQSM
 .  ..||  |......  .. | .  |  |  |.  ..  .. .. .| .    ..  ......  || ..      ... .
ellleflelvrealael.pkggpvlVHCsaGvgRtGtfi..aaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfly

0045450 (Phosphotyrosine protein) phosphatases II 1508-1786 4.7e-43 143.5 In-house 8-300 (307) alignment
Range on Protein: 1508-1786
Range on HMM: 8-300/307.0
VESYEKLLENLHVKMLNGKTQLGAKWQELQQKLDKEaaANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK-----QTDDYINAAYMKNLSA-------G
.....|||  .....|...| | . ...|..  ..    ...|..  .   .|||. |.||||| ||||       ...||||| |..  .         
fidalkllllvllllldfltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

CPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQAlDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMH-GADAVLDLSLLQLKQ
. .||..|.|.|.|..||| |.| ......|.| .. ||     ..|||.  ...  |...|||.|....|...  ..|..... | . .. .  .. . 
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WTKGAPAQLLGVAENALETHRQRCKAAnAPQSPLIMNCLTGSERSELVAIgvCAIIATQNKQPIL---LNTIDVWSRICAQRQNSLRDSAILEQSMQIV
|  .   . .  . . .|  |. ...   ...| .  |  |  |.  ...  . .. .| ..      ..  ...... .|| ..      ... ....
wpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfia..aylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

0043336 (Phosphotyrosine protein) phosphatases II 1511-1775 1.6e-41 138.0 In-house 4-262 (278) alignment
Range on Protein: 1511-1775
Range on HMM: 4-262/278.0
YEKLLENLHVKMLNGKTQLGAKWQELQQKLDkeaaaNKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMkNLSAGCPNFIVAQTPQ
...||. |  ..||.|| | . ..||..        . .|... .   .|||. |.||||| ||||.  .    .||||| |. ..   ...||..|.|.
vkdllkallelllnlktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPl

PNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPqalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGV
|.|..||| |.| ....|.|.| .. ||    ...|||   .... |.|.|||.||...|...  ..|.....| . ..    .. . |  .     |  
petvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsl

AENALETHRQRCKaanAPQSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQNSLRD
  . |.. |....    ...|..  |  |  |. ...  .. .. .| .    ..  ......  || ...  
lldflkavreale...dsngpvlVHCsaGvgRTGtfi..alyllleqlekeggvdleeavkelreqRpgavqt

DSPc_SM00195 1536-1770 1.5e-40 134.5 In-house 5-242 (263) alignment
Range on Protein: 1536-1770
Range on HMM: 5-242/263.0
LQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP
  .||....  .. .... |   .|||. ..||||| ||||.|.     .||||| |.|       ..|..| |.|.|..||| |.| ||....|.|  .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmltee

NEL----FDPYWPQALDQPTHYDDYTVTCLKVQQLS-HCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAP---AQLLGVAENALETHRQRckaanapQS
.|      | |||.  .... .....|.. .|.. . ..  ..|.|...| .   ..  .| |.|.. |.|    ..| . . . .....        ..
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......sg

PLIMNCLTGSERSELVAIGVCAIIATQNKQPilLNTIDVWSRICAQRQ
|..  | .| .|.  ..   ...   ....   ..  ......  || 
pivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRp

PTPc_SM00194 1536-1770 1.5e-40 134.5 In-house 5-242 (263) alignment
Range on Protein: 1536-1770
Range on HMM: 5-242/263.0
LQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP
  .||....  .. .... |   .|||. ..||||| ||||.|.     .||||| |.|       ..|..| |.|.|..||| |.| ||....|.|  .
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmltee

NEL----FDPYWPQALDQPTHYDDYTVTCLKVQQLS-HCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAP---AQLLGVAENALETHRQRckaanapQS
.|      | |||.  .... .....|.. .|.. . ..  ..|.|...| .   ..  .| |.|.. |.|    ..| . . . .....        ..
eengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......sg

PLIMNCLTGSERSELVAIGVCAIIATQNKQPilLNTIDVWSRICAQRQ
|..  | .| .|.  ..   ...   ....   ..  ......  || 
pivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRp

0040439 (Phosphotyrosine protein) phosphatases II 1550-1781 2.8e-37 124.1 In-house 4-237 (249) alignment
Range on Protein: 1550-1781
Range on HMM: 4-237/249.0
STTIAKLFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQ
|... .  ..|||. |.||||| ||||        .||||| |. ...  ...||..|.| |.|..||| |.| ......|.| .. ||    ...|||.
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

alDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAAnAPQSPLIMNCLTGSERSelVAIG
  .... |.|.|||.|.|......  ..|.|.... . ..    .|   |      . .  . . .|  |. ....  ...|..  |  |  |.   .. 
..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRt..Gtfi

VCAIIATQNKQPILLNTIDVWSRICAQRQNSLRDSAILEQ
.. .. .| .    ..  .... .  || ..      ...
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrf

0042113 (Phosphotyrosine protein) phosphatases II 1554-1771 7.7e-36 119.1 In-house 6-224 (245) alignment
Range on Protein: 1554-1771
Range on HMM: 6-224/245.0
AKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQalDQ
 .  ..|||. |.||||| ||||        .||||| |. ...  .|.||..| |.|.|..||| |.|.....|.|.| .. ||    ...|||.  ..
lpenkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

PTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAanAPQSPLIMNCLTGSERSELVAIgvCAI
.. |.|.|||.|....|...  ..|.....| | ..    ..   |  . .. ||   ...||  |. ...   .. |..  |  |  |. ....  . .
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfia..ayl

IATQNKQPILLNTIDVWSRICAQRQN
...| .    ..  ..  ..  || .
mleqlekelgvsleeavkelrsqRpg

0037934 (Phosphotyrosine protein) phosphatases II 1555-1745 7e-32 106.3 In-house 8-202 (243) alignment
Range on Protein: 1555-1745
Range on HMM: 8-202/243.0
KLFPEKNRSLDCLPYDHARVKLDKqtDDYINAAYMKNLsagcPNFIVAQTPQPNTIND----FWSMIWSEKSRTVVCLHTPN----ELFDPYWPqalDQP
.   .|||  |.||||| ||||.   .||||| ... .    |..|. | | |.|..|    || |.|.......|.| ..     |  ..|||   .. 
penlsknrysdilpydhsrvkleg..sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev

tHYDDYTVTCLKVQQLSHCSEYQLKLSMHG-ADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRCKA-----ANAPQSPLIMNCLTGSERSELVAI
 .|.|.|||.|....|...  . |.|....  | ..    ..   |  . . .      . |.  |. ...     |. ...|..  |  |  |. ....
.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtlia

GVCAI
    .
aylml

0045098 (Phosphotyrosine protein) phosphatases II 1559-1740 3.1e-31 104.2 In-house 35-225 (278) alignment
Range on Protein: 1559-1740
Range on HMM: 35-225/278.0
EKNRSLDCLPYDHARVKldkqtdDYINAAYMKNLsaGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQalDQPTHYDDYTV
.|||  | ||||| |||      ||||| |..    . ..||..| | |.|..||| |.|.......|.| .  ||     ..|||   ...  |.|.||
dknRykdilpydhsrVk......dYINAsyidgy..p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltygdftv

TCLKVQQLSHCSEYQLKLSMH----GADAVLDLSLLQLKQWTKGAPAQLL--GVAENALETHRQRCK----------AANAPQSPLIMNCLTGSERSELV
|.|....|..     |..         .  . .  |... |  . .  |       ..||  |...|           .. .. | .  |  |  |.  .
tllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtl

AI
..
va

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1518-1771 5.4e-31 102.9 In-house 18-268 (298) alignment
Range on Protein: 1518-1771
Range on HMM: 18-268/298.0
LHVKMLNGKTQLGAKWQELQQKLDkEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDF
  ||  .. |.. ...|.|..  . |  ... . . ..   .|||  | ...|..|| | |    .  |||||..... . | . ||..|.| ..|..||
aavkkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhayk.grnafiatqaPltetvedF

WSMIWSEKSRTVVCLHTPNEL----FDPYWPQAldQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAQLLGVAEnaLE
| |.. |.. |.| |.. .||    .  |||.   . ..|.. ||. |. .. .     .||.| .  .    .  |.  .|. ||.|..   | .  | 
WrmvteedigtiVmltnleeldktkyhkywPde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvld..ll

THRQRcKAANAPQSPLIMNCLTGSERSELVaIGVCAIIATQNKQpillNTIDVWSRICAQRQN
.. .. .  .| ..|.|..|  | .||    | . ...   .|.    ...||.  . . |..
rkvra.sqqqagnkpvivqCsaGvgRsGtf.iaidsvlervkke....qvvDvfqvvkvlRkk

subfamily_PTPRD_pd Subfamily PTPRD 1518-1737 2.1e-30 100.9 In-house 14-230 (564) alignment
Range on Protein: 1518-1737
Range on HMM: 14-230/564.0
LHVKMLNGKTQLGAKWQELQQKldKEAAANKRSTTIaklFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDF
..    |.....  ........  ..   .. .  .     .|||  . ..||| ||.| |    .  ||||| ...       ..| .| | ..||.||
vaklkansdlkfeeeykkieeg..qqftweaankpa...NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedF

WSMIWSEKSRTVVCLHTPNEL----FDPYWPQAlDqPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAQllgvAENALE
| |.| ..|.|.| |   .|     .. |||.  . ...|...|||  . ..|.. .  ..||...  . .      .  .|  .|.| .    |.. |.
WRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes....atslLd

THRQRCKAANAPQSPLIMNCLTGSERSEL
  |.  ....  . |..  |  | .|.  
lirkvralnepdagPivVhCSaGVGRTGt

subfamily_PTPN6_pd Subfamily PTPN6 1501-1770 1.5e-29 98.0 In-house 2-274 (306) alignment
Range on Protein: 1501-1770
Range on HMM: 2-274/306.0
TKYFQKEVESYEKLLENlhVKMLNGKTQLGAKWQELQQKLDKEAAAnkRSTTIAKLFPEKNRSLDCLPYDHARVKL---DKQTDDYINAAYMK-NLSAGC
|.  .||.|. .. ||.   .   .|. .  ...||||.  |.     |. .  .   ||||    ||.||.||.|   . . .||||| |.| ..   .
tsllakeieqrvselek..eeeslekagfeeefeelqqeeakklls..rkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd

PNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALDQPThYDDYTVTCLKVQQLSHCSEYQLKLS-MHGADAVLDLSLLQLKQW
 ..| .|   ..|..|||.|.| |.|| .| . . .|       .|||.. .... | ...||... ..|..    .|..| .. ..   ..  .. |.|
ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksW

TKGAPAQLLGVAENALETHRQRCKAAN-APQSPLIMNCLTGSERSELVAigVCAIIATQNKQPILLNTIDVWSRICAQRQ
   .  .  |.  . ||. ... .  . | . |... |  |  |   .   |  |.  . ..  |   ||. . .   |.
PdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfi..viDillkliekkgldadidiqklvksvre

subfamily_PTPRB_pd Subfamily PTPRB 1528-1771 8.8e-29 95.4 In-house 26-263 (293) alignment
Range on Protein: 1528-1771
Range on HMM: 26-263/293.0
QLGAKWQELQQkLDKEaaaNKRSTTIAKLFPEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSR
..  ...||.. ..|.   .. ... ..   .|||  . |||||.||||    |....||||| |......   .||..| | |.|..||| |.| .||.
rfseeyeelka.vgkd...qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyns.prefiatqGPlpetvddfWrmvwekkss

TVVCLHTPNE----LFDPYWPQAlDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMhgADAVLDLSLLQLKQWTK-GAPAQLLGVAENAlETHRQRCkAAN
..| |    |      . |||.  ..|. | | .|| .. ..|..    .||..   ...  ..  .. . |.  | | .   . .   .| |..    .
iivmltqlvekgkvkCeeYWPad.eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfv.rtvreai.ekt

APQSPLIMNCLTGSERSElVAIGVCAIIATQNKqpilLNTIDVWSRICAQRQN
| ..|... |  |  |.  . | .  .. . ..     ...|. . ... |..
askrPivvhCsaGvGRtG.tfialdrllqaiee....edyvdifgivaelRee

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1525-1771 2.4e-28 94.0 In-house 19-257 (288) alignment
Range on Protein: 1525-1771
Range on HMM: 19-257/288.0
GKTQLGAKWQELqQKLDKEAAANKRSTTIAKlfpEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDFWSMIWSE
..|..  ... |  .|.|. . .. . .  .   .|||  . ||||. ||||.|    .. |||||.|...   .  ..| .|.| ..|.|||| ... .
nrtgfseeynsL.aalektksvtagrlavna...kknRyrnilpyDekrvklkkleeeagaDYinasyidgek.kkkkyiatqgPladtvndfWelvyen

KSRTVVCLHTP----NELFDPYWPQAlDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSmhGADAVLDLSLLQLKQWTK-GAPAQllgvAENALETHRQRCK
|. |.| |       ..  . |||.| |.|..| . ||| .....| .  . .| |        |..  .| . |.  | |..    ... ||  ||   
ktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPes....kapllellrqvkv

AANAPQSPLIMNCLTGSERSELVaIGVCAIIATQNKqpilLNTIDVWSRICAQRQN
| .| . |.|. |  |  |.    | . |.| . ..     ..||| . ..  |..
anqadtgpiivhCsaGvGrtgtF.ialdalidavee....edyiDvagtvaklRkq

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1509-1770 1.7e-27 91.3 In-house 5-257 (318) alignment
Range on Protein: 1509-1770
Range on HMM: 5-257/318.0
ESYEKLLENLHVkmlNGKTQLGAKWQELQQKLDKEaaANKRSttIAKLFPEKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLSAGcPNFIVAQT
| .|. ...|.    .|...| . ...|... ..   .. .|  . .    |||  . |.|||.||||...    . ||||| |.    .   ..| ||.
edleshvrrlre...sGelllseeyerlsrseetv..tslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrk.kayiaaqa

PQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAPAQL
| |.||.||| |.|  .|...| |   .|      . |||.  .....|.. .|.  .  .||.    ..|.. .. ... .    .  .|.  | |.. 
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg

lgvaENALETHRQRCKAA-NAPQSPLIMNCLTGSERSelvaiGVCAIIATQNKQPILLNTIDVWSRICAQRQ
     . |.  ||  ||  .. ..|... | .|  |      ||  .. .. ..    ...||.  .   |.
....aslldlvrqvskaqqksgagpivvhCsaGvGrt.....GvfiavdillerikaealvDvfqtvkqlre

subfamily_Ptp69D_pd Subfamily Ptp69D 1524-1769 8.8e-27 89.0 In-house 17-262 (307) alignment
Range on Protein: 1524-1769
Range on HMM: 17-262/307.0
NGKTQLGAKwQELqQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWS
...|. | . .|  .|| ..    . ...  |    |||. |  ..|. |||| |    .. ||||| ..|       .||.|| |  .||.||| ||. 
krdtdfgla.key.ekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyke.kkkfiaaqdPveatigDfWRmiae

EKSRTVVCLHTPNELFD----PYWPQAldQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGAD-----AVLDLSLLQLKQWTkgaPAQLLGVAENALETH
 .. ..| |   .|  .     |||.   . ..|.|  |.. . .. |.  . .|..|. ...     .   .   . ..|      .   ||.  |.  
qevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk...DskvPevargllkli

RQRCKAANAPQSPLIMNCLTGSERSELVaIGVCAIIATQNKQpillNTIDVWSRICAQR
.|  .  .  .||... | .|..|| .. . .. ..  ...     ...|..  ..  |
eqvrelyklnrsPivvhCsaGvgrsgif.valdsllqqlkae....dkvdifetvkdLr

subfamily_PTPN3_pd Subfamily PTPN3 1559-1773 1.2e-26 88.2 In-house 43-258 (280) alignment
Range on Protein: 1559-1773
Range on HMM: 43-258/280.0
EKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAG---CPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALDQpTHYDD
.|||  | ||||..||||.... ||||| |..  . .     ..|..| | ..| .||| |.| .||...| | |  |        |||.  |. ..| .
sknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPetede.leyge

YTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAPAqllgVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIGVCAIIATQN
..|.| | .. . .   .| |. . ..    .  ||  .|.  | |      ... ||  ..  |. .. ..|... | .| .|. .. .   |.  ...
fsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPd....dsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalaliea

KQPIllNTIDVWSRICAQRQNSL
..|.  . .|. ...  ||.. .
aepv..ypldivrtmrdqramlv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1559-1781 1.7e-26 88.0 In-house 11-230 (250) alignment
Range on Protein: 1559-1781
Range on HMM: 11-230/250.0
EKNRSLDCLPYDHARVKLDKQT----DDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL---FDPYWPqaLDQPTHYDD
||||  | ...|..|| | |.      |||||....  .     ||..|.| ..||.||| |.. ||| |.| | . .|    .  |||   .....| |
eknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywP..vekaekyGd

YTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAQLLGVAENALETHRQRCKAANapqSPLIMNCLTGSERSELVaIGVCAIIATQN
 ||. |. .. .     .|||| .       .  |.  .|  || |..   | |   . .... .| |   .|.|..| .|  ||    | . |..   .
vtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagn...aPvivqCsaGvgrsGaf.iaidavlerlk

KQpillNTIDVWSRICAQRQNSLRDSAILEQ
|.    ...||.  | . |..  .    |||
ke....kvvdvfkvikvlrkdrphavesleq

subfamily_PTPRG_pd Subfamily PTPRG 1509-1770 1.9e-26 87.4 In-house 4-267 (563) alignment
Range on Protein: 1509-1770
Range on HMM: 4-267/563.0
ESYEKLLENLHVkmlNGKTQLGAKWQELQQKLDKEAAANKRSTTIAKlfPEKNRSLDCLPYDHARVKLDKQTD-----DYINAAYMKNLSAGcPNFIVAQ
. ..| . .||    .|.. . .....||..  ..    . |        .||| |. ..||..|||| . ..     ||||| |..    .  .||..|
kefakhvaslha...dgdigfseefealqsetiskdldaehsqkpen..krKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqks.kafiatq

TPQPNTINDFWSMIWSEKSRTVVCLHT----PNELFDPYWPQalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSM----HGA--DAVLDLSLLQLKQWT-
 | ..|..||| ||| ... ..| .       ..  | |||.  |.. .|.  .||  . ..|.  .. .|..      ..   | ..     .  .|  
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

KGAPAQLLGVaenaLETHRQRCKAANAPQSPLIMNCLTGSERSelvaiGVCAIIATQNKQPILLNTIDVWS---RICAQRQ
.|.| . | |    |   ... .| .|   |... | .|  |.     |.  .. |  ||    |...|.    .| |||.
hgvPehslpv....LifvkkssaankaeaGPivvHcsaGvgrt.....GtyivldtllkqiqqenavnvfgflkhiraqRn

subfamily_PTPN12_pd Subfamily PTPN12 1526-1771 5.9e-26 86.0 In-house 7-255 (290) alignment
Range on Protein: 1526-1771
Range on HMM: 7-255/290.0
KTQLGAKWQELQQKLDKEAAAN--KRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWS
. .. ...|.|..  .|  | .  ..... ..   .|||  | ||||..||.| |..    .||||| ..|.  .|  ..| ||.| |.|..||| |||.
eeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgv.egkleyiaaqgPLpktlddfWrmiwe

EKSRTVVCLHTPNEL----FDPYWPQALDQPTHYDDYTVTCLKVQQLSH-CSEYQLKLSMHgaDAVLDLSLLQLKQWT-KGAPAQLLGVAEnALETHRQR
 . . || .    ||     . |||.  ..........||. . .....     .||. ..  ..   .  .. ..|  .| |..   . |  .|. |..
knveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssakslle.lielvrel

CKaanAPQSPLIMNCLTGSERSelVAIGVCAIIATQNKQPILLNTIDVWSRICAQRQN
 .   . ..||.. |  |  |    .| .  .. .. |. .. ...||.. .   |..
qe...sedaPlvvhCsaGvGrt..Gtiiaidyvrellkaekipeeldvfdlvlelrkq

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1549-1770 3.3e-25 83.6 In-house 37-254 (315) alignment
Range on Protein: 1549-1770
Range on HMM: 37-254/315.0
RSTTIAKLFpEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFD----PYWP
|..     | .|||  . ||.|.|||||    |.  .|||||.|.| .      .| .|.|.. ...|||.|.. ||  |.| .   .|        |||
rvaretinf.kknryknilPldsarvkleviddsPdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

QALDQPTHYDDYTVTCLKVQQLSHCSEYQLklSMHGADAVLDLSLLQLKQWTK-GAPAQlLGvaenALETHRQRCKAANAP-QSPLIMNCLTGSERSELV
.   . ...  . |. |.... .     .|   .  ...   ..  |...| . |.. | ..    .|    .  || | . . .|.. |..|  |. .|
drkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkq.ts....sllklikevkadngkkefsllvhcsaGvGrtGvv

aIGVCAIIATQNKQpillNTIDVWSRICAQRQ
 | .  ..|  ...    ...||.  .   |.
.isidevvaqikrt....rsvdvfnfvknlra

subfamily_PTPN13_pd Subfamily PTPN13 1553-1770 7.6e-24 79.4 In-house 33-249 (273) alignment
Range on Protein: 1553-1770
Range on HMM: 33-249/273.0
IAKLFPEKNRSLDCLPYDHARVKLDKQTDdYINAAYMKNL-SAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALDQPT
  |   .|||  . ||||..||||....  ||||...|        ..|..| | |.|..||| |.|  |.. .. . .  |      . |||.  ....
kkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

HYDD-YTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAQLLGVAEnaleTHRQrCKAANAPQSPLIMNCLTGSERSE-LVAIGVCA
   . ..|. ||||.|.  .  .|...   . .. ... |.. .|   | |.. . . .      ..  .  .  ..|... | .|  ||  |..| |  
kvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellq....fvae.vrrlqtdagPivvhcsaGiGrsGtlitidvvl

IIATQNKqpiLLNTIDVWSRICAQRQ
 .  ..|    ..  ..  ..  |||
glierdk...efdvkeivrklreqrq

subfamily_PTPN1_pd Subfamily PTPN1 1531-1771 7.7e-24 78.9 In-house 6-249 (290) alignment
Range on Protein: 1531-1771
Range on HMM: 6-249/290.0
AKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHT
 ...|. ....|||   . ...  .   ..||  |  ||||.|.||...  |||||. ..   |   ..|..| | |||.. || |.| .||..|| |  
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleeak.rsyiltqGPlpntvdhfWqmvWeqkskavvmlnk

PNE----LFDPYWPQALD-QPTHYD--DYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQLLGVAENALETHRQRcKAANAPQSP
  |        ||||  . .   ..   ..|. .. .. |.    .|.|    ..   ...     .|.  .  .  .   . |   |.   . .  . |
vvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvres.GslssdvGp

LIMNCLTGSERSELVAIGVCAIIATQNKQPilLNTIDVWSRICAQRQN
 .. | .|  ||  ...  . ..  ..|.   |...|.  .... |. 
avihcsaGiGrsGtfclvdtclvliekkdd..lssvdikkvllelrky

subfamily_PTPRK_pd Subfamily PTPRK 1558-1768 1.4e-23 78.2 In-house 44-255 (314) alignment
Range on Protein: 1558-1768
Range on HMM: 44-255/314.0
PEKNRSLDCLPYDHARVKLDKQTDD----YINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELF----DPYWPqalDQPTHY
 ||||| | |.||..||.|    .|    |||||..        .|||.| | ..|..||| ... |.. ..| |    | .      |||   .. ..|
reknrsgdilaydrsrvflitidgdpssdyinaalidsykr.paafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP...edtevy

DDYTVTCLKVQQLSHCSEYQLKLSM--HGADAVLDLSLLQLKQWTK-GAPAQllgvAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVaIGVCAII
.|  |...... |.      ....   .| ...  .  .|  .|.. . | .    |.  |.  |.  |  .  . .... |..|. |.    | .. ..
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvs....atgllklvrrvkksqeeeaGrivvhCsaGaGrtGtf.iaidivl

ATQNKQpillNTIDVWSRI---CAQ
   ...    ...||.  .   ...
dmiere....gvvdvfnavktlrsr

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1525-1774 4.4e-23 76.7 In-house 18-259 (287) alignment
Range on Protein: 1525-1774
Range on HMM: 18-259/287.0
GKTQLGAKWQELQQKLDKEaaaNKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRT
|...   ... |.|  ..|   ..   .||.   .|||. . |..|  || | .. .|||||....  .    .||.|..|  ||. .|| .|. ..  .
gnegfknqftvleqvtqre...devthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykek.kafiiaesPmfntarnfWkliddrnvta

VVCLHTPNE----LFDPYWPQALDqpTHYDDYTVTCLKVQQLSHCSEYQLKLSMHG-ADAVLDLSLLQLKQWTKGA----PAQLLGVAENALETHRQRCK
.| |   .|        |||.     . . .|... |. .. ... | .|..  .. |.. . .   |. .| .      |.  | | |.   |.|.| .
ivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgn

aanapqSPLIMNCLTGSERSELvaigVCAIIATQNKQPiLLNTIDVWSRICAQRQNSLR
      ..... |  .  || .     ||.  | ||      .||| . .  ||.    
......tsivvhCsdtvGrsam....fcaaattinkck.teGviDvfqvlksqriqkpg

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1532-1740 1.6e-22 74.9 In-house 16-228 (281) alignment
Range on Protein: 1532-1740
Range on HMM: 16-228/281.0
KWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSaGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVC
 ..|  .|| .    |  . . |.   .|||  .   ||..|||.    .... ||||| ... .. |  ..|..|.| |.....|| |.|..| ...| 
GfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgyk.gekeyiatqgPvPaslvafWqmvweqkvsaivm

LHTPNE---L-FDPYWPQAlDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVlDLSLLQLKQWT-KGAPAQLLGVAENALETHRQRCKAANapqS
.    |   |    |||.  .. ..| |.||. .. .. ..  | ..||........ ... |. ..|  .|.||.   . |   | .. . |  .    
vtreieagklkChrYWPdd.nselkygdvtvkstaeeekatyierkfkleresgetr.eveqlaytaWPdhGvPattkellefrkevlkltekktk...a

PLIMNCLTGSERSE-LVAI
||.. | .|  |.   .|.
plvihCsaGvGrtGtyial

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1524-1787 1.7e-22 74.6 In-house 13-280 (290) alignment
Range on Protein: 1524-1787
Range on HMM: 13-280/290.0
NGKTQLGAKWQELQQKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT------DDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMI
||...   ....  ..||. .  ..  . ...   ..||. ....||  |. | . .      ..||||.|.|. .    ..|..|.| .||. |||..|
nghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkli

WSEKSRTVVCLHTPNEL----FDPYWPQAlDQPThYDDYTVTCLKVQQLSHCSEYQLKLSMHGA-DAVLDLSLLQLKQWTKGA-PAQLLGVAENALETHR
| ||.  .| | . .|        |||.. |. . |. .... |. ..|..  | .|..  . . .|   .  .|.. | .    ..  ..     |  .
wqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

QRCKAANapqSPLIMNCLTGSERSELVaigvCAIIATQNKQP--ILLNTIDVWSRICAQRQNSLRDSAILEQSMQIVL
.. |  |    .... |  .  || .     ||.  | ||       . ..|  .   |. .|.     ..  .||||
tqrkrgn...tsivvHCSdtvgrsavf....caaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivl

subfamily_PTPN14_pd Subfamily PTPN14 1519-1750 1.9e-22 74.7 In-house 12-258 (300) alignment
Range on Protein: 1519-1750
Range on HMM: 12-258/300.0
HVKMLNGKTQLGAKWQELQQKLDKEAAAnKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK---QTDDYINAAYMKNLSAG-CPNFIVAQTPQPNTINDFW
..|.|. | . |  ..| ..   |.. | . ||.  .   ||||  | |||...||.|     ....||||. .|   .|   ..||||.|...|..|||
rakilekkleegkvfteyeripkkreda.llstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfW

SMIWSEKSRTVVCLHTP----NELFDPYWPQA--LDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAQLLGVAE--N
 |.| .. . .| |       .|    |.|.     .  ... . ||   ... . .   .|||    .    ..  || . |. .| |  . |  .  .
qmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLe

ALETHRQRCKAAN---APQSPLIMNCLTGSERSELVAIGVCAIIATQN
 ..  |.. .  .     . |... |. |  |.  . .    | . ..
evqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatleh

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1559-1767 2e-22 74.0 In-house 45-250 (515) alignment
Range on Protein: 1559-1767
Range on HMM: 45-250/515.0
EKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQALDQPTHYD
.|||  . |||| .||||    |.   ||.||.|.. . .    .| .|.|.. ...|||.... |.  |.. .   .|        |||.   .  .. 
kknryknilPydsvrvklevindnPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfG

DYTVTCLKVQQLSHCSEYQLKlsMHGADAVLDLSLLQLKQWT-KGAPAQllgvAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVaIGVCAIIATQ
 . |  . ..  .     .|.  .   | .  .   ....|  ||.| .    .   |   ..     .  . |||. |..|  |  .| | .  ..|  
sikvelvsleactggikrklt..vlkgddsrtvtqfhfteWPdkGvpkh....tssllklikevkadhgqythpliihcsaGvGrtGvv.isidsvvaha

NKQpillNTIDVWSRICA
..     ...||.  .  
ktt....rmvdvfnfvtn

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1514-1770 2.1e-22 74.6 In-house 10-263 (319) alignment
Range on Protein: 1514-1770
Range on HMM: 10-263/319.0
LLENLHVKMLNGKTQLGAKWQELQQKLDKeaaanKRSTTIAKLFPEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNT
| |.|.    .|.|.|   ...|..  ..     . ...  .   .|||  . |.||..||.|    ...  |||||...        .|| .|.|  ||
Lkerlkalastgetllekefkllkeavnd.....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlent

INDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQAldQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADA-VLDLSLLQLKQWTK-GAPAQLLGVA
|.||| |.| |.| .|| |   .|        |||..  ....|  ..|| .. ..|..    .|||  . ..    ...  | ..|.  . | ..... 
iedfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

ENALETHRQRCKaanAPQSPLIMNCLTGSERSElvAIGVCAIIATQNKQPillNTIDVW---SRICAQRQ
.   . .. | |     . |... |  |. |    .  |  ..  . |.    ...||.   ||. .||.
dllkrirksrek...tqsgPivvhCsaGvGRtG..tfivldamlervkee...gvlDvfstvsrlRtqRn

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1551-1771 3.6e-22 73.6 In-house 27-244 (283) alignment
Range on Protein: 1551-1771
Range on HMM: 27-244/283.0
TTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMK--NLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE----LFDPYWPQAld
 . |.  ..|||  . .|.|  ||.|. .. |||||...   .      ..|.||.|  .|. ||| |.. ||  ..| |    |        |||.   
iasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr..

QPTHYDDYTVTCLKVQQLSHCSEYQLKLSMH-GADAVLDLSLLQLKQWTKGAPAQLLgvaeNAL-ETHRQRCKAANAPQSPLIMNCLTGSERSELVaIGV
    | ..|||  |       .  .| | .   | . | |.  |. .|..  .   .    |.|    . . .  . ...|... | ||  |.    |..
GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaii....nslvkfnkvislqteskkgPivvhCstgiGrtavf.iaa

CAIIATQNKQPIllntIDVWSRICAQRQN
 | .     . .    .|| . .   |..
sasvkdaltesv....vdvfavvkimreq

subfamily_CG7180_pd Subfamily CG7180 1547-1735 4.7e-22 73.0 In-house 32-237 (296) alignment
Range on Protein: 1547-1735
Range on HMM: 32-237/296.0
NKRSTTIAKLFPEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFD---PYW
..  . . |   ||||  ...|||..|| |.|    ...|||||.|.  .     ..|| ..|. .|...||.... |.. .|| |  . .       ||
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkk.keyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsyw

PQALdqPTHYDDYTVTCLKVQQLSHCSEYQLKLSMH-------GADAVLD---LSLLQLKQWTK--GAPAQ---LLGVAeNALETHRQRCkAANAPQSPL
|.     ..| .  |  ....|...   ...||  .        .. . .   . |.||..|      |     |. .  .  .. |..    .  ..|.
pnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielr.rrvrlwrekv.dedpeegPv

IMNCLTGSERS
.. .  |. ||
vvvssdGasRs

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1537-1771 5.7e-22 73.2 In-house 29-262 (297) alignment
Range on Protein: 1537-1771
Range on HMM: 29-262/297.0
QQKLDKEAAANKRSTTIAK--LFPEKNRSLDCLPYDHARVKLDKQTDD----YINAAYMKNLSAgcpNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHT
....    .|| ...| |.  .  ||.|  . ||||  ||||    ||    |.||...|       ..|  |.|...|..||| |.. |.  |.| |  
seeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnd

PNE---LFDPYWPQALDQPthYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTKGAPAQ--LLGVAENALETHRQRCKAANapQSPLI
 ||       ||..   ..  . | .|. | |.. .  .. .|...   | |   .   |  .| . |  .        . ..  |.  .  .  ..||.
dnerdkkcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqna..egPll

MNCLTGSERSElVAIGVCAIIATQNKQpillNTIDVWSRICAQRQN
. ||.|  |   | . .  ..|  ...    ...|..  .   ||.
vhclaGvGrtg.vlltidsvvaeakre....kevdifglvkklrqe

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1549-1771 2e-21 71.6 In-house 51-269 (319) alignment
Range on Protein: 1549-1771
Range on HMM: 51-269/319.0
RSTTIAKLF--PEKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHtpNELFDPYWPQA
   | | |    .|||  . |..|...|||..       |||||....        .| || |..||..||| |||  .. |.| |   ..    |||. 
adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqr.kdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywplk

LDQptHYDDYTVTCLKVQQLSHCSEYQLKLSMHGAD-AVLDLSLLQLKQWT-KGAPAQLLGVAenALETHRQRCKAANAPQSPLIMNCLTGSERSElVAI
 ..  ... . |    |.. .     ...|| .|    . ..    .. |  .| | .   .    |  . .  .  .  . .... | .|. |.  | |
ivi..keerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlm..rlvkkvrhltskenhranivvhcsaGvGrtG.vyi

GVCAIIATQNKQpillNTIDVWSRICAQRQN
 . ...   ...    . .||.  .   ||.
vldvlldrmkee....kqvdvynfvrdlrqq

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1559-1772 2e-21 71.7 In-house 27-234 (284) alignment
Range on Protein: 1559-1772
Range on HMM: 27-234/284.0
EKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHtpNELFDPYWPQALDQptHYDDYTV
.|||  . |..|...|||..       |||||....        .| .| |..||..||| |||  .. |.| |   ..    |||.  ..  ... . |
dknrighilafdknvvklerliGeefsdyinasfitGyqr.kdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplkivi..keerfkv

TCLKVQQLSHCSEYQLKLSMHGAD-AVLDLSLLQLKQWT-KGAPAQLLGVAenALETHRQRCKAANAPQSPLIMNCLTGSERSElVAIGVCAIIATQNKQ
    |.. .     ...|| .|    . ..    .. |  .| | .   .   .|  . .  .  .  ...... | .|. |.  | | . ...   ...
kvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlm..rlvkkvrhltskenhranivvhcsagvgrtg.vyivldvlldrmkee

pillNTIDVWSRICAQRQNS
    . .||.  .   ||. 
....kqvdvynfvrdlrqqr

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1526-1734 2.7e-21 71.0 In-house 21-229 (305) alignment
Range on Protein: 1526-1734
Range on HMM: 21-229/305.0
KTQLGAKWQELQQKlDKEAAANKRSttiAKLFPEKNRSLDCLPYDHARVKLDKQTD--DYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSR
...| |....|... ..    .|..   |.   .....   |. |. ... ....|  |||||.|..  .    ..||||.| .||..||| .|. || .
dkgleaqykslyee.eesidvgkke...ankaknrlkeitlldddriiltekeslddsdyinasyvdgykr.kkkyivaqgPlkntvadfWrliveekvs

TVVCLH----TPNELFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSM-HGADAVLDLSLLQLKQWT-KGAPAQllgvAENALETHRQRCKAA
|.| |       ..    |||..  .........|.    .. |   | .||.|. .. .    .. .|| .|  .| | .    |   |.  ..  |. 
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf....atsllslikrvqkdq

NAPQS-PLIMNCLTGSER
.  .  ||.  |  |  |
kkdkgvpllVhCsagvgR

subfamily_PTPRN_pd Subfamily PTPRN 1521-1737 4.1e-21 70.0 In-house 23-240 (297) alignment
Range on Protein: 1521-1737
Range on HMM: 23-240/297.0
KMLNGKTQLGAKWQELQQKldkEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQT----DDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSM
. |. |..| ..|. | .    ||  . .... |. . .|||| ..|||||.||||....    .|||||. . .     | .| .|.| ..|. ||| |
dhlknkdrlekewealcay...eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqm

IWSEKSRTVVCLHTPNE----LFDPYWPQALDQptHYDDYTVTClkVQQLSHCSEY------QLKLSMHGADAVLDLSLLQLKQwtKGAPAQllgvAENA
.| . .  .| | . .|      . |||.   .   |. | |    | .   | .|         |  . . .|  .  |  ..  .|.||.    | . 
vweqGvvvivnltrleeegvkqckrywpdeGse..vyhiyevhl..vsehiwcddylvrsfylknlqtsetrtvtqfhflswpe..egvPas....aksl

LETHRQRCKAANAPQSPLIMNCLTGSERSEL
||  |.  |.     .|... |  |. |.  
lefrrkvnksyrGrscpivvhcsdGaGrtGv

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1524-1737 2.3e-20 67.6 In-house 7-226 (287) alignment
Range on Protein: 1524-1737
Range on HMM: 7-226/287.0
NGKTQLGAKWQELQQKLDKEAAANKRSTTIAKlfPEKNRSLDCLPYDHARVKLDKQ---TDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSE
. | .. .. . |..  .  .|  |... .|.   .|||  | ||.|..|| | ..     ||||| |.        .||.||.| . |..||| ... .
rvkddvdkevdalkedsesstatfkaaeelaa..vkknryadvlPiddtrvllsaegelGsdyinanyvasytdd.eafiaaqgPiaatvrdfwravlet

KSRTVVCL-HTPNEL---FDPYWPQAlDQPTHYDDYTVTCLKVQQLS--HCSEyQLKL-SMHGADA--VLDLSLLQLkqWTKGAPAQLLGVAENALET--
.| .|. . .  .|       |||.  ..|     |.|. |. ....  ..    |.|  ... .|  |  | ||.     |...   .|..  .|.   
rsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvr.alrlidletrearvvkqldllsw..PdkvlaPtavglirfvldvkq

HRQRCKAANApQSPLIMNCLTGSERSEL
| .  . |.    ||.. . .|  || .
hielardase.vGPlvvhddvGiGrsGi

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1559-1783 2.4e-20 67.7 In-house 51-269 (315) alignment
Range on Protein: 1559-1783
Range on HMM: 51-269/315.0
EKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP----NELFDPYWPqalDQPTHYD
.|||  . ..||..||.|     ..  ||.||....  .     .| ||.|......||| ... |.  ..| |       ..  . |||   |.   | 
qknryiniiaydksrvqlpllendphsdyvnanfidGynk.krryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp...dkkviyG

DYTVTCLKVQQLSHCSEYQLklSMHGADAVLDLSLLQLKQWTkgaPAQLLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELvAIGVCAIIATQN
 .|||  . .. .. .   |  |.   | . ..  |..  |     ...   . . .. .|.  .  ..  ..... |  |  |.    | . |..   .
kitvtrkseevnteytvrtl..svvfgdnirevvqlhytswp...dmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGt.fitldavldqae

KQpillNTIDVWSRICAQRQNSLRDSAILEQSM
 .    | |||.  |   |||  .  ...||  
ae....naidvynfitgvrqnrikmvqvaeqyq

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1558-1771 4e-20 67.0 In-house 29-246 (274) alignment
Range on Protein: 1558-1771
Range on HMM: 29-246/274.0
PEKNRSLDCLPYDHARVKLDK-----QTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFD----PYWPQALDQ--P
 .|||  . || ...|| | .     .  .|||| |.|  .     .. .| | |||..||| ||. |... .| |   .|        |.|.| |    
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

THYDDYTvtcLKVQQLSHCSEYQLK-LSMHGADAVLDLSLLQLKQWT-KGAPAQLLGVAENALETHRQRcKAANAPQSPLIMNCLTGSERSEL-VAIGVC
 .|.|     .||..  .. .|... |... .    ..      .|  . .| .   . .  ||....| ...||. .| .. |  |  |    .|| ..
erygdve...ikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesr.eeenaklapvvvhCsaGiGrtGcfiaisia

aiiATQNKQpilLNTIDVWSRICAQRQN
     | ..    ...|| . .|  |..
...vrqlre...eivvdvlkivcnlrld

subfamily_PTPN9_pd Subfamily PTPN9 1538-1698 9.9e-20 65.7 In-house 23-191 (297) alignment
Range on Protein: 1538-1698
Range on HMM: 23-191/297.0
QKLDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE
... .|... .  ..  ..  ||||  | | ||..||.| |.    . ||||| ..         || .| | ..|..||| |.| .. ...|      |
aeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykq.kkafiatqGplkktvsdfWrmvWeqevlvivmttrvve

----LFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWTK-GAPAQ
        |||.  .. ... |..|. ..|.. ..  . .|...    .    ..  |.  |   | | .
rgrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPss

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1560-1740 1.4e-19 65.3 In-house 6-191 (237) alignment
Range on Protein: 1560-1740
Range on HMM: 6-191/237.0
KNRSLDCLPYDHARVKLDKQ--TDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHT---PNEL-FDPYWPQAlDQPTHYDDYT
|||  .   |||.|| |     . |||||.|.|..     ..| || |  .. .||| |.| ||   .| |      |||    |||.. |||. |  .|
knrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvlt

VTCLKVQQLSHCSEYQLKLSMHGADAvlDLSLLQLKQWTKgAPAQllGVAENALETHRQRCKAANA-----PQSPLIMNCLTGSERSELVAI
|.  | ...|  .   | ||...     .. |..  |.|   | .  || ...    | | .  |        .| |. | .|  |. .. .
vslkkkeefsdytvrslllskrltlk..evrlihqyqfts.wpdr..gvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflv

subfamily_PTPRA_pd Subfamily PTPRA 1512-1771 3.7e-19 63.8 In-house 17-276 (330) alignment
Range on Protein: 1512-1771
Range on HMM: 17-276/330.0
EKLLENLHVKMLNGKTQLGAKWQELQQ-KLDKEA-AANKRSTTiaklfpEKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSAgCPNFIVAQTP
||| |...... .   ..  ... |   ...    .|.|          |||| .. ||||..|| | .    .. |||||....       .|| || |
ekleeeirirsaddnklfreefnalPagpiqatlelaskeenk......eknrvvnilPydfsrvilsvkeGveesdyinasfidGyke.kdkfiaaqGP

QPNTINDFWSMIWSEKSRTVVCLHTPNE----LFDPYWPQalDQPTHYDDYTVTCLKVQQLSHCSEYQLKLS----MHGADAVLDLSLLQLKQWTK-GAP
. .|..||| |||  || |.| |   .|        |||.  .    | . .|.  ... | . .  .. .     .   ...  .. . .. | . | |
keetvedfwrmiweqksativmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvP

AQLLGVAENALETHRQRCKAANapqsPLIMNCLTGSERSELVaIGVCAIIATQnKQPILLNTIDVWSRICAQRQN
..  |. .   . .... . |.    |... | .|  |.    | . |...   |   ...  .. .|. .|| .
fepiGmlkllkkvkklnqqsag....pivvhcsaGvGrtGtf.ivldavlerv.kaerkvdvfefvkrlrlqrpq

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1541-1752 1.1e-18 62.2 In-house 5-229 (270) alignment
Range on Protein: 1541-1752
Range on HMM: 5-229/270.0
DKEAAANKRSTTIAKlFPEKNRSLDCLPYDHARVKLDKQTD----DYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPN----
|||.. ..   ..|.  .. ||. | ||  ..||.|.. ..     |||| |..  .    ..| |..|.|.|...|| |||.||....| .   .    
dkeetsesdlpeaar.gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgr

ELFDPYWPQALDQPTHYDDYTVTCLKVQQLSH--CSEYQLKLSMHGADAvlDLSLLQLKQWT-KGAPAQLLG--VAENALETHRQR---CKAANAPQsPL
.  . |||.  .. ... | ... |....  .      .|.|  .|      |   . ..|  .|.| .  .   ... |.. |.    .|  .  . ||
kkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeer..rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.Pl

IMNCLTGSERSE-LVAIGVCAIIATQNKQ
.. |  | .|.  |.|.  .  .  ..|.
lvHcsaGvgRtGtlialDiavrlLeetkk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1559-1771 2.7e-18 61.2 In-house 50-266 (325) alignment
Range on Protein: 1559-1771
Range on HMM: 50-266/325.0
EKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVC---LHTPNELFDPYWPQALDQPTHYDD
.|||  . ...|..|| |  .      |||||.|...   .   |. ||.|...||||.| ..   ..  ||    | . ..    |||. . .  ..  
aknrfknvvaldksrvvletkkddpssdyinasylrdd.kkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGg

YTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT----KGAPAQLLGVAEnALETHRQRCKAANAPQSPLIMNCLTGSERSelvaiGVCAIIA
  |    ....|     .|..        . .  .||. |     .  || |. . .  ...  .| .|     .|... | .|  |.     || . . 
levklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilq.lvkavservtantkastpilvhcsaGvGrt.....Gvfisly

TQNKQPILLNTIDVWSRICAQRQN
.  .. |    .|..  .   |..
salakvieesrvdifgfvkklrkd

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1556-1748 5.4e-17 56.3 In-house 44-195 (392) alignment
Range on Protein: 1556-1748
Range on HMM: 44-195/392.0
LFPEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFdpywpqaldqpthydd
   .|||  . |||| |||||    |   .||.||.|.... .    .| .|.|.. ...|||.|.. |.  |.. .   .|                  
inlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd................

ytvtclkvqqlshcseyqlklsmhGADAVLDLSLLQLKQWTKG-APAQllgvaENALETHRQRCKAANAPQS-PLIMNCLTGSERSELVaIGVCAIIAT
                          | .   .  .. .|     | .      ..|    .  ||     . |||. | .|  |. .| | . ...| 
........................kgddartvaqfhftewPdkdvpkh.....tssllkfikevkadfGqythpliihcsagvgrtgvv.isidsvvah

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1546-1697 1.1e-16 55.6 In-house 22-172 (267) alignment
Range on Protein: 1546-1697
Range on HMM: 22-172/267.0
ANKRSTTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP-NELFDPYWPQALD
 .. |. ||.   |.||  | ||||..|| | .....||||.|..    .   ||| | |  ||| ||. .|  .|  ..| |..   .    .||  . 
sstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktk.nafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmg

QPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGaDAVLDLSLLQLKQWTKGAPA
|  .|.| ||     ..        |.| ..  ..  ...|   |.|   .  
qakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkwnintnn

0049772 (Phosphotyrosine protein) phosphatases II 1557-1770 1.6e-16 56.4 In-house 46-255 (314) alignment
Range on Protein: 1557-1770
Range on HMM: 46-255/314.0
FPEKNRSLDCLPYDhARVKLDK---QTDDYINAAYMKNLsagcPNFIVAQTPQPNTINDF----------WSMI--WSEKSRTVVC--------------
 ..|||.||.||.|  ||.|..   .. ||||| |...      .||..|.| ..|..||          |.|.  .  ..|..|.              
nrdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LHTPNELFdpywpqaldqpthyD--------DYTvtclkvqqlshcseyqlklsmhgadavldlS----------------------------
       | .. ...              .        ..                               .                            
aAlgKtpllildgng..............neptaadlellk..............................eelydpelferlgikylripvpDgsapll

-LlqlkqwtkgapaqllgvaenaletHRQRCKAANA--PQSPLIMNCLTGSERSE-LVAIGVCAIIATqnkqpilLNTIDVWSRICAQRQ
                           .. ... ..  ...|... |  |  |.  .|... . .          ..  ...... ..| 
ed........................fdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllg.......vsleealedvrlkRp

subfamily_ptpA1_pd Subfamily ptpA1 1540-1642 3e-15 50.9 In-house 30-138 (418) alignment
Range on Protein: 1540-1642
Range on HMM: 30-138/418.0
LDKEAAANKRSTTIAKLFPEKNRSLDCLPYDHARVKL----DKQTDDYINAAYMKNlsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL-
|..    .. |    |    |||  . || .|.||.|    ||.  ||||| |.    |   .||..| | |||| ||| |.| .. | .| |   .|  
leesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresenc

---FDPYWPQA
    | |||. 
rikcdrywpeq

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1526-1662 1.2e-14 48.8 In-house 14-154 (301) alignment
Range on Protein: 1526-1662
Range on HMM: 14-154/301.0
KTQLGAKWQELQQKLDKEAAANKRSTTIAKlfpekNRSLDCLPYDHARV------KLDKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWS
.... ....||... ||..  . ...  |      ||  .  .||. |.      .||... .|||| |... |    .||.|| |  .|. ||| .|| 
snkfeeqykelkegedksctvglseenkal.....nrfknitvyddnriilkpkpnldlcqreyinasyidgysek.kkfiaaqgpmkktlvdfWrliwq

EKSRTVVCLHTPNEL----FDPYWPQALDQPTHYDDYTVTCLKVQQL
||  ..| .   .|        |||..  . ...   |||  . | .
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvy

subfamily_egg_pd Subfamily egg 1557-1742 1.3e-14 48.6 In-house 40-223 (307) alignment
Range on Protein: 1557-1742
Range on HMM: 40-223/307.0
FPEKNRSLDCLPYDHARVKLDKQ----TDDYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPN--ELFDPYWPQALDQPTHY-
. || ||      | .||||. .    .||.| | ..|       .||.||.|  || .||| |.. |. . .| | .    |  . |||.| ...  . 
nlekarskrvhckdssrvklelrrGqylddfihanrvkGk.pllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtv

-DDYTVTCLKVQQLSHCSEYQLKLSMHGADavldLSLLQLKQWTKGapAQLLGVAENALETHRQRCKAAnapqSPLIMNCLTGSERSE-LVAIGV
   . ...|||.. .       || . |.|       . |. |      . ..     |.  |.  ...     | ....  |  ..  |||| .
pGslrienlkvdskadplfrvtklklvGgd....deerflehwqgd..vnnssdvysplrvlrklrnls....kpvvvqdilGvskaatlvaiei

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1555-1655 4.5e-14 47.0 In-house 31-138 (297) alignment
Range on Protein: 1555-1655
Range on HMM: 31-138/297.0
KLFPEKNRSLDCLPYDHARVKLDKQ--TDDYINAAYMKNLSAGCP-NFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPN----ELFDPYWPQALDQPT
.    |||  | | .| .|||| .     ||||| |.       . ..|.|| |  .|..||| ... .  |..| .   .    .   ||||.. ..  
nsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerl

HYDDYTVT
.  |. | 
kagdvvve

0051429 (Phosphotyrosine protein) phosphatases II 1580-1785 8.1e-14 47.4 In-house 3-220 (272) alignment
Range on Protein: 1580-1785
Range on HMM: 3-220/272.0
TDDYINAAYMKNLsaGC---PN-FIVAQTPQPNTINDFWSMiWSEKSRTVVCLHTPNELF----DPYWP----------QALDQPTHYDDYTVTCLKVQQ
...|||| ... .  |    |. .. .. | |.|..||| . .... .|.|.| ...|.     |.|||             ...  | ...||.|....
lsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

LSHCSEYQLKLSMH-GADAVLDLSLLQLKQWTKGAPAQ--LLGVAENALEthrqrckaanapQSPLIMNCLTGSERSELVAIGVCAIiaTQNKQPILLN-
|...  . | |... .|.... . .|.  .|     .|  || . |  |.            . |... |  |  |. .|.  .  .   .      .. 
lldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld............ggpvlvHCsaGkdRTGtvvalllll..lgvsletivdd

-------TIDVWSRICAQRQNSLRDSAILEQSMQI
         ...... ||| ..  . . ... ...
Ylltnlyleeaveelraqrpgavqteeqylflyea

subfamily_CG42327_pd Subfamily CG42327 1559-1658 1.4e-13 45.2 In-house 30-138 (319) alignment
Range on Protein: 1559-1658
Range on HMM: 30-138/319.0
EKNRSLDCLPYDHARVKLDK----QTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQ--ALDQPTH
.|.| .. .|  ..|| |..    . | |..|.|..        .| ||..  ..  ||| ..|  .||..|.|  . ||       |.|   .||.   
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

YDDYTVTcLK
| |. || ||
yGdilvt.lk

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1559-1654 2.9e-13 44.3 In-house 49-160 (350) alignment
Range on Protein: 1559-1654
Range on HMM: 49-160/350.0
EKNRSLDCLPYDHARVKLD------------KQTDDYINAAYMKNL---SAGCPNF--IVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDP
 |||  . |||.|.||||              .|.||||| |.|         |.|  | .|.| |.|..||. .|   | . .. | .  ||    .. 
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPQaldqpTHYDDYTV
||..       |||.||
YWqe.....gsydditv

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1552-1772 3.1e-13 43.8 In-house 46-267 (302) alignment
Range on Protein: 1552-1772
Range on HMM: 46-267/302.0
TIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTI---NDFWSMIWSEKSRTVVCLHTPNEL---FDPYWPQALDQ
.. |  ..||.| |.  .|. .|||... |.|.||. ..  . . .. |.|| |. ..    ..|| |...||  .|| |  ..||   .. ..|.  ..
kafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgd

PTHYDDYTVTCLKVQQLSHCS-EYQLKLSMHGADAVLDLSLLQLKQWTKGAPAqlLGVAENALETHRQRCKAANAPQSpLIMNCLTGSERSELVAIGVCA
 ..|..  |   ||.. .    .| . .  .|    .  ..  |..| .        .|| . . .    | ..| .. ...    |. |   .   . |
ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvp..vkyaeliktaakvfakkikaden.tvivSknGaGRagafltlava

IIATQNKQPIllNTIDVWSRICAQRQNS
.   |...    |  ..   | .|| ..
veklqkgkep..nikeivksiRsqRpra

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1559-1760 6.6e-13 43.0 In-house 58-256 (290) alignment
Range on Protein: 1559-1760
Range on HMM: 58-256/290.0
EKNRSLDCLPYDHARVKLD-KQTDDYINAAYMKNLSagcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLH----TPNELFDPYWPQALDQPTHYDDYT
.|||  |    | .|| |.  .  ||. | |.| |    . ||..| .  .|. |.| |.  ||  ..| |       .   ..|.|.   .   . ..|
kknrykdvvcndktrvilkdGydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeit

VTCLKVQQLShCSEYQLKLSMHGADAVLDLSLLQLKqwTKGAPAQLLGVAENALetHRQRCKAANApQSPLIMNCLTGSERS-ELVAIGVCAIIATQNKQ
|.| . ..       .  ||.   |.  .  |  ||  .|  | . .  .. ||   |      .|   |... | .|  |.  .||| |.. | .. |.
vlcseeddkd.aniikktlsvrdkdsGkehklkhlk..ikswpdksvalstlal..lrtlrilrka.sGpvvvhcsaGiGrtGtfvaievglqilldGke

PILLNTID
  ||... 
ldlldlvr

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1554-1736 6.8e-13 42.8 In-house 44-227 (439) alignment
Range on Protein: 1554-1736
Range on HMM: 44-227/439.0
AKLFP-EKNRSLDCLPYDHARVKLD----KQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFDpYWPQalDQPTH
|. .   |||  |  ..||.|| |.         |||| |.|        .| .|.|. .| .||| ... .|. |.| |    | .  |||   |. . 
aqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyydd.klyiatqgpkkettddfwrlviekktvtivmltnlvesyk.ywps..daevc

YDDYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT---KGAPAQLLGVaenaLETHRQRCKAA-NAPQSPLIMNCLTGSERSE
| | .| . .  .| .     .|.  .   .  . ..||..  .   |  |||   |    |.  |    |  .    |... | .|  |. 
ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashv....ldflrainsandkeeygpvvvhcsagvGrtG

0041856 (Phosphotyrosine protein) phosphatases II 1559-1653 8.3e-13 43.8 In-house 3-76 (182) alignment
Range on Protein: 1559-1653
Range on HMM: 3-76/182.0
EKNRSLDCLPYDHARvkldkqTDDYINAAYMKnLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHtpnelFDPYWPQALdqpthyddyT
.|||  | ||||| |        ||||| ..   |    .||..|.| ..|..||. |..... .|.|.|       ..|||. |         .
dknrysdilpydhsr......dldyInanlyl.gslpatrfiatqgpllstvadflrmlkelgittivnlt.....eelywpell.........e

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1550-1740 2.4e-12 41.5 In-house 34-229 (307) alignment
Range on Protein: 1550-1740
Range on HMM: 34-229/307.0
STTIAKLFPEKNRSLDCLPYDHARV--KLDKQTDDYINAAYMKnLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE----LFDPYWPQAL
..   .  ..|||  |    |..|.  |.|  . ||| | |.  ..    .||.|| |. ||. .||.|.  ||  .|. |    |      . |||   
tveafsantdknryqdvkcqdkgrivvkfdglasdyihanylg.iaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

DQPTHYDD----YTVTCLKVQQLSHCSEYQ--LKLSMHGADAVLDLSLLQLKQWT-KGAPAQLLGvAENALEthrqrckAANAPQSPLIMNCLTGSERSE
 |   . .     .|. | ...|.   ..    .| .  |.    .. || ..|  .|.|   |. | | ||       | .  . |... | .|  || 
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinlt.ainlle.......avrydtnpvvvhcsaGvGrsG

-LVAI
 .|||
tivai

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1550-1751 4e-12 40.7 In-house 28-234 (285) alignment
Range on Protein: 1550-1751
Range on HMM: 28-234/285.0
STTIAKLFPEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP----NELFDPYWPQALDQ
. |  .  |. ||  |    . .|| | ..  ||| |..|.        .| .| | |.|..||| ||. ||   |. | |      |    |.|. | .
tytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

PTHYDDYTVTCLKVQQLSHCSEYQLKLSMHG-ADAVLDlSLLQLKQWTKGAPAQLLGVAENALETHRQRCKAANAPQSPLIMNCLTGSERS-ELVAIGVC
  ..  | .|  .... . .      |..    ||  .  |   .      | ||       .    .  |  |  . |. . | .|  |.  .| |  .
vvkfgkyeitlteckeeaiagtilnaltvintedasse.plymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidya

AIIATQNK
.|   .| 
tirimenp

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1559-1775 1.2e-11 39.2 In-house 10-223 (239) alignment
Range on Protein: 1559-1775
Range on HMM: 10-223/239.0
EKNRSLDCLPYDHARVKLDKQTD----DYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE----LFDPYWPqalDQPTHYD
 |||  . . |||.|| |.| ..    |||||.|...       .| .|     .  ||| |.| |.   .| |    |        |||   |  ..| 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskyc

DYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAqllgVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIgVCAIIATQ
.  ||  | . ..      . .|  |      .   ..  |  || |      |   |  .|.  | .     | .. | .|  |.  . . . |..   
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpq....yatavlglrrkitkdslpgarpwvihcsagvgrtgaflv.idamlrqa

NKQpillNTIDVWSRICAQRQNSLRD
.||    .|.|..  . | |..  . 
kkq....ktvdifnyvkairedrphm

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1559-1777 1.3e-11 39.1 In-house 9-224 (239) alignment
Range on Protein: 1559-1777
Range on HMM: 9-224/239.0
EKNRSLDCLPYDHARVKLDKQTD----DYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE----LFDPYWPqalDQPTHYD
 |||  . . |||.|| |.| ..    |||||.|...       .| .|     .  ||| |.| |.   .| |    |        |||   |  ..| 
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskyc

DYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT-KGAPAqllgVAENALETHRQRCKAANAPQSPLIMNCLTGSERSELVAIgVCAIIATQ
.  ||  | . ..      . .|  |      .   ..  |  || |      |   |  .|.  | .     | .. | .|  |.  . . . |..   
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpq....yatavlglrrkitkdslpgarpwvihcsagvgrtgaflv.idamlrqa

NKQpillNTIDVWSRICAQRQNSLRDSA
.||    .|.|..  . | |..  .   
kkq....ktvdifnyvkairedrphmvq

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1554-1667 4.8e-11 36.8 In-house 49-162 (310) alignment
Range on Protein: 1554-1667
Range on HMM: 49-162/310.0
AKLFPEKNRSLDCLPYDHARVKL--DK-QTDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFDP----YWPQaLDQp
 | .  |||  | .  | .||||  || . .||| | |.|        ||..| |   || ||| ||. |.. ... |    |   |    |||  |   
ykkymhknrysdvvcldtsrvklkidksryedyihanyvktnyl.rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgv.

thydDYTVTCLKVQQLSHCSE
      |  |..| .||  ||
....tetygcirvtnlsesse

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1559-1692 1.3e-10 35.4 In-house 98-231 (244) alignment
Range on Protein: 1559-1692
Range on HMM: 98-231/244.0
EKNRSLDCLPYDHARVKLDKQ--TDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNElFDPYWPQALDQPTHYDDYTVTC
 |||    ||.|  || | |    . ||||...  |     ..|..| |  .|  ||| |.   .   .| | . .|  | |||..     . .| ||| 
wknregaglpfdfnrvplskgsmgntyinasfvgclgr.taeyiltqhpladtsmdfwkmmlerhvnvlvvlgsvee.edeywpdseplewyeeditvtl

LKVQQLSHCSEYQLKLSMHGADAVLDLSLLQLKQWT
   ...      .|..     ..   |...|. .| 
tdrdefknikasnleiesdmneshqaltmfqisnwp

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1560-1739 2.4e-09 31.3 In-house 40-219 (281) alignment
Range on Protein: 1560-1739
Range on HMM: 40-219/281.0
KNRSL--DCLPYDHARVKL---DKQTDDYINAAYMKNLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCL----HTPNELFDPYWPQALDQPTHYD
||| |   ||   . ..|.   .|.. ||| | |..        .|..| |. .|  ||| ||| |.. ..| |     |  |    |.|.      ..|
knrylnipcldisrvqlkvkmpnknstdyihanyirspfl.krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfd

DYTVTCLKVQQLSHCSEYQLKLSMHGADAVLDLSLlqLKQWTKgapAQLLGVAENALETHRQrCKAAnapQSPLIMNCLTGSERSEL-VA
 ..|.             .|.||  |   ..   |   |.|      |. . .|  |.  |.  .|     .| .. | .|  ||   .|
klsvsyedstvnkslvttrlnlsyegetrlithwl..wkewpd...wqvpessevmlkilrk.irar...stppvihcsagvgrsgtlma

0043147 (Phosphotyrosine protein) phosphatases II 1580-1648 2.8e-09 32.5 In-house 4-55 (172) alignment
Range on Protein: 1580-1648
Range on HMM: 4-55/172.0
TDDYINAAYMkNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPnelfdpywpqaldqptH
 .||||| |. .|.   ..||. | | .||..||| |..... ...|.| .                  
gsdyinasyl.dlyyipdrfiatqgplrntladfwrmlkelgithivnltel................l

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1559-1634 1.3e-08 28.8 In-house 49-120 (303) alignment
Range on Protein: 1559-1634
Range on HMM: 49-120/303.0
EKNRSLDCLPYDHARVKLDKqtDDYINAAYMKnLSAgCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL
.|||  | .  ||..|||      || |.|.. | .   . |..| | . |  ||| ||  .| . |. | | .| 
dknrfvdvicldhskvklsd..ssyihasyle.lds.skkailtqlplshtaadfwqmiieqkvkcvlllltdsey

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1559-1634 1.3e-08 28.5 In-house 50-144 (349) alignment
Range on Protein: 1559-1634
Range on HMM: 50-144/349.0
EKNRSLDCLPYDHARVKLDK------------------QTDDYINAAYMKNLSAGC-PNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL
 |||  | |||.|.|||| |                  . |||||| |.|         .|  | | | |..||. .|  .. . |. |   .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkel

0046846 (Phosphotyrosine protein) phosphatases II 1582-1740 3.3e-08 29.0 In-house 13-128 (176) alignment
Range on Protein: 1582-1740
Range on HMM: 13-128/176.0
DYINAAYMKNlsagcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQALDQPThyddytvtclkvqqlshcseyqlklsmhga
||||| ..       . .|. | | |.|. ||. |..... ..||.| .. ||     . |||.  .                                 
dyinanlilg.....srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................

davldlsLLQLKQWTKGAPAQLlGVAENALETHRQRCKAAnapqSPLIMNCLTGSERSELVAI
         .   |  . . .|    ...||  |.. |.      | .  |  |  |. ....
.......qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlva

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1570-1632 4.3e-08 27.1 In-house 59-120 (347) alignment
Range on Protein: 1570-1632
Range on HMM: 59-120/347.0
DHARVKLDKQTDDYINAAYMKNlSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPN
....     ... ||||...|       ..|..| | |.|. ||| |.   |   || .  | 
eksknsraddvetyinashikf.dnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1551-1746 4.4e-08 27.5 In-house 34-229 (288) alignment
Range on Protein: 1551-1746
Range on HMM: 34-229/288.0
TTIAKLF---PEKNRSLDCLPYDHARVKLDKQTDDYINAAYMKnlSAGC-PNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP----NELFDPYWPQA
  |.. |   | ..|  .    | .||||.  .| ||.|  .   ||     .| ||.|   ||. .| |. ..  . .| |        |  . |.|  
idiidsfianptrdryenlprcditrvklsddpdfyiaanvvs..sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

LDQPTHYDDYtvtCLKVQQLSHCSEYQLKLSMHGADAVLDL----SLLQLKQWTKGapaqllGVAENALETHRqRCKAANAPQSPLIMNCLTGSERSELV
| . ...  .   |  |..     .  .|.|.     . .       | |..| .       || || |   |  ..  .. | |... . .|. |.  .
lGekarigrl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWddd......gvPenylsplr.llevlkslqkPivvhssaGvGrtgtl

AIGVCAII
.. . |. 
ililiale

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1550-1647 5.9e-08 26.7 In-house 51-150 (305) alignment
Range on Protein: 1550-1647
Range on HMM: 51-150/305.0
STTIAKlfpEKNRSLDCLPYDHARVKLDKQT-DDYINAAYMKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQALD
|. ||.    |||  |    |.. ||||| .  ||| | |.         ||.|| |  .||..|| |.  .|   .| |    ||       ||| |  
sadiai...tknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqg

QPT
.  
ekl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1559-1628 8.5e-08 26.3 In-house 50-119 (305) alignment
Range on Protein: 1559-1628
Range on HMM: 50-119/305.0
EKNRSLDCLPYDHARVKLDKQ-TDDYINAAYMKNlSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCL
.|||  |    |. ||||.     .|| | |.    .    || .|.|  .|  ||| | . .|  ..  |
gknrykdvgcldnnrvklegpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifml

subfamily_eak_pd Subfamily eak 1539-1659 1.4e-07 25.2 In-house 34-159 (332) alignment
Range on Protein: 1539-1659
Range on HMM: 34-159/332.0
KLDKEAAANKRSTTIAKLFPEKNrSLDCLPYDHARVKLD---KQTDDYINAAYMKNLSAGcPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNE--
.||.   .   | |      ..|  .. .|||.  |.|    .  . ||||. ..    |  ..|..  .. . .  || |.  .|| ..| |    |  
dlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevG.rkyiltGiasedkvfafwqmvleqkspaivqlledvelk

--LFDPYWPQALDQPTHYDDYTVTCLKV
   .| |.|.   .  ..  . |.. . 
leksdkyfpdktreelkfGildverkef

0036282 (Phosphotyrosine protein) phosphatases II 1581-1658 1.5e-07 26.8 In-house 2-61 (174) alignment
Range on Protein: 1581-1658
Range on HMM: 2-61/174.0
DDYINAAYMkNLSAGCPNFIVAQTPQPntindFWSMIWSEKSRTVVCLHTPNEL----FDPYWPQaldqpthyddytvtclK
.||||| .. .||   |..|. | | .     || |.......|||.| ...||    .  |||                 .
sdyinaspl.dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................l

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1579-1787 1.9e-07 25.6 In-house 44-256 (290) alignment
Range on Protein: 1579-1787
Range on HMM: 44-256/290.0
QTDDYINAAYMKnLSAGCpNFIVAQTPQPNT-------INDFWSMIWSEKSRTVVCLHTPNE------LF--DPYWPQALDQPTHYDDYTVTCLKVQQLS
 .|||| | ...  . |  ..|. |.|| ..       |..|| |.  ||.. || |   .|      ||    | |.. ..   ... || | .  .  
fnddyiHAnrvt.cpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskeked

HCSEYQLKLSMHGaDAVLDLSLLQLKQWTKgapaqlLGVAENALeTHRQRCKAANAPQSPLIMNCLTGSERSE---LVAIGVCAIIATQNKQpillNTID
   . .| .   . .  . .   .||.|.|      | | |. . |  .  .  .| ..| |. |  |  ||     . .|   |. |....    .. |
dvetRelvvkfdd.eeeftvtHsllkgWnk......lnvqedtk.tllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv....kled

VWSRICAQRQNSLRDSAILEQSMQIVL
| . .  ||.. . .   |   .  ..
vlkalrkqralaitsalelafvdagiv

0044763 (Phosphotyrosine protein) phosphatases II 1568-1683 3.8e-07 25.4 In-house 1-76 (178) alignment
Range on Protein: 1568-1683
Range on HMM: 1-76/178.0
PYDHARVKLDKQTD----DYINAAYMKnlsagcPNFIVAQTPQpntiNDFWSMIWSEKSRTVVCLHTPNELF----DPYWPQALDqpthyddytvtclkv
|.|. ||.|..  .    ||||| ..       |...... |.     |.. ... .. ...|.| .. ||.    |||||.  .               
pldrtrvllsnleglersdyinaseil......pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...............

qqlshcseyqlklsmhgadavldL
                       .
.......................i

subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 1537-1659 5e-07 21.5 In-house 10-126 (275) alignment
Range on Protein: 1537-1659
Range on HMM: 10-126/275.0
QQKLDKEAAANKRSTTIAKlFPEKNRSLDCLPYDHArvkLDKQTDDYINAAymKNLSAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFD
|| ||     ...   . .   ||||  .   .|.    ||.. ....  |  . . .   ||...|.|. .|  |.  ..|  . .||||| .|.|   
qqdlddlnlddekierfir.ngeknrftnvtcfdei...ldrenqeffvha..ntfrtpygnflisqapndstnadhlhllwiynvqtvvclvlpeeagg

PYWPQALDQPTHYDDYTVTCLKV
 . |.  .  | .. | .  . .
yfvpkegetftsfqkyqiktigi

0049260 (Phosphotyrosine protein) phosphatases II 1598-1740 9.2e-07 24.2 In-house 10-108 (152) alignment
Range on Protein: 1598-1740
Range on HMM: 10-108/152.0
NFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTPNELFDPYWPQALdqpthyddytvtclkvqqlshcseyqlklsmhgadavldlsLLQLKQWTKGAPA
 || .| | |||..||| |... . .|.|.| .. ||  ....|                                             .  .|  . . 
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlpwpDhgvp

QLLGVAENALETHRQRckaANAPQSPLIMNCLTGSERSELVAI
.|  . . .|. ....   |  .. | .  |  |  |. ....
dlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlva

0051082 (Phosphotyrosine protein) phosphatases II 1581-1745 1e-06 23.9 In-house 3-116 (151) alignment
Range on Protein: 1581-1745
Range on HMM: 3-116/151.0
DDYINAAYMKNLsagcpnFIVAQTPQPntinDFWSMIWSEKSRTVVCLHTPNELFdpYWPQALDQPThyddytvtclkvqqlshcseyqlklsmhgadav
.||||. |. .       ... . | .    ||. ...... .|.|.| .. |    |.|. | .                                   
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

LDLSLLQLKQWTKGAPAQLLGVAENALETHRQrckaanAPQSPLIMNCLTGSERSELVAIGVCAI
...  ...  |.     ...  . ..||  ..       .. |... |  |  |. .... .. .
ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylml

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1582-1692 4.6e-06 20.6 In-house 76-189 (301) alignment
Range on Protein: 1582-1692
Range on HMM: 76-189/301.0
DYINAAYMKNLsAGCPNFIVAQTPQPNTINDFWSMIWSEKSRTVVCLHTP----NELFDPYWPQALDQPTHYDDYTVTCLKVQQLSHCSEYQLKLSMHGA
  | | ...        ||..|.| .|| .||| |.   .  ..| |       .|  . | |.   .  . . ....  . ... . . .. .| .. .
vPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleveds

DAVLDLSLLQLKQWT
   ..   .   |..
tgkfatrtvthyqys