Gene csw in Drosophila melanogaster

Synonym: 19-106, CG3954, CSW, Csw, Csw/Shp2, Dmel\CG3954, E(sev)1A, EG:BACN25G24.2, SHP-2, Shp-2, Shp2/csw, anon-WO03040301.207, anon-WO03040301.209, anon-WO03040301.219, csw/SHP-2, l(1)2Db, l(1)2Dd, l(1)G0170, l(1)GA114, l(1)csw, Dmel_CG3954, csw

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP045_AA protein Get Run
DmelP045_AA_317-747 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 536-753 3.3e-103 339.9 In-house 97-301 (306) alignment 
Range on Protein: 536-753
Range on HMM: 97-301/306.0
EreremfKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVS--WRDQPAR
.      |.||||||||     .||.|||.||||||.|||||||||.|||||||||||||| ..|..|. ....|||.|..||.|||..||  .... .|
d......ksyiatqgcl....ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeer

RIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAgeKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEA
..|.|||..|||||||.|||.||.||.|||..|..|..|  ..|||.|||||||||||||||||..|..| ..|||..||||.....||.|||||||||.
evfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteq

QYKFVYYAVQHYIQTliaRK
||||||.|...||.|   .|
qykfvykaikkyiet...kk
0039614 (Phosphotyrosine protein) phosphatases II 321-748 2.3e-82 272.1 In-house 28-291 (297) alignment 
Range on Protein: 321-748
Range on HMM: 28-291/297.0
QLVKGGFWEEFESLQQDSRDtfsRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDgdlynmsssseslnssvpscpactaa
.. |.....|||.|..   |   . .....||. ||||..||||||.|||| ...... .  ||||.|.  .                            
ansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl..........................

qtqrncsncqlqnktcvqcavksailpysncatcsrksdslskhkrsessassspssgsgsgpgssgtsgvssvngpgtptnltsgtagclvgllkrhsn
                                                                                                    
....................................................................................................

dssgavsismaerererereMFKTYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKeKCARYWPDEGRseQFGHARIQCVSENSTSDYTL
                    . ...|||||.    . .|| |||.|||.....|||| ||. |.|. |||.|||.||   ..|. .. ....   ..||.
....................ltrkfIatqgP....lpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytv

REFLVSWrDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQM
|.. |.  ... | . |...  ||||||| ..  .|.||. |......|    .|.||..||||||.|||||||.....|.|. ..    ..|.. ....
rtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealael....pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavke

VRSQRSGLVQTEAQYKFVYYAVQHYIQT
.|.||.| |||. ||.|.|.|.......
lreqRpgavqtpsqyrflydallellkr
0046845 (Phosphotyrosine protein) phosphatases II 542-749 1.1e-73 243.4 In-house 76-277 (284) alignment 
Range on Protein: 542-749
Range on HMM: 76-277/284.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWR--DQPARRIFHYH
 |..||||| |     ||| |||.|||..|.||||| |.. |.|.||||.|||.|| . ..|. .. ..||.  .|||.|.. ...   ... |.. |.|
kkkfIatqgPl....pntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfh

FQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
.  |||||||..|  .|.||..|.. ...     ...|||.||||||.|||||||..|..|.|. ..||....|.. .....|.|| | |||..||.|||
ytswpdhgvppspedlleflrlvrellen....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvy

YAVQHYIQTL
.|...|....
ealleylklk
0050432 (Phosphotyrosine protein) phosphatases II 539-749 5.8e-73 241.2 In-house 73-302 (308) alignment 
Range on Protein: 539-749
Range on HMM: 73-302/308.0
R-------------------------------EMFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDE--GRSEQFGHA
|                                  ...|||||.|     ||| ||| |||..|.||||| ||..|.|.||||.|||.|  | |...|. 
rykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPl....pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkf

RIQCVSENSTSDYTLREFLVSW-RDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQshlaqageKPGPICVHCSAGIGRTGTFIVIDMILDQIV
.. ..|| . .|||.|.. ... .|.. |.. |.|.  ||||||| .|  .|.||. |....        ..|||.||||||.|||||||..|..|.|. 
tvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl........pggpivVHCsaGvGRtGtfialdllleqle

RNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTL
..    ..|.. .....|.|| | |||. ||.|.|.|...|....
ke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_PTPRD_pd Subfamily PTPRD 543-749 2e-71 236.3 In-house 91-284 (564) alignment 
Range on Protein: 543-749
Range on HMM: 91-284/564.0
KTYIATQGCLLtqqvNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVSENSTSDYTLREFLVS-WRDQPARRIFHYHFQ
|.|||||| |     .|. ||| |||..|...||| ||  |.||.||..|||..| .|..|.  .. ..|.  .||..|.| ..  ... .| . ..|| 
kayIAtqgPla....etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFt

VWPDHGVPADPGCVLNFLQDVNTRQShlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||||||  .  .|.....|.. ..      .. ||| ||||||.||||||||||..|..|     .  .||  .....|.||  .|||| || |...|
sWPdhgvpesatslLdlirkvralne......pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFihea

VQHYIQTL
......  
ilealacg
0036941 (Phosphotyrosine protein) phosphatases II 543-750 3.1e-70 232.1 In-house 78-281 (297) alignment 
Range on Protein: 543-750
Range on HMM: 78-281/297.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDE-GRSEQFGHARIQCVSENS--TSDYTLREFLVSW-RDQPARRIFHY
...|||||.|     ||| ||| |||..|..|||| |...|.|.||||.|||.| | | ..|. .....|...   .|||||.. |.  .... |.. |.
rkfIatqgPl....pntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthf

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
|.  ||||||| .|  .|.|.. |......|     ..||..||||||.||.||||..|..|.|. ..    ..||  .....|.|| | |||. ||.|.
hytgwpdhgvpespaslldfielvrkvlkll....psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

YYAVQHYIQTLI
|.|.......  
yeallellkkkl
0040438 (Phosphotyrosine protein) phosphatases II 543-762 3.5e-70 232.1 In-house 86-292 (317) alignment 
Range on Protein: 543-762
Range on HMM: 86-292/317.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHYHFQ
...|||||.|     ||| |||.|||.....|||| |.. |.|.||||.|||. | . ..|. .....||   ...|||.. |.  .|.. |.. |.|. 
rkfIatqgPl....pntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhyt

VWPDHGVPADPGCVLNFLQDVNTRQShlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 ||||||| .|  .|.||. |.. ..      ...||..||||||.|||||||.....|.|. ..|   ..|.. .....|.||.| |||..||.|.|.|
gWpdhgvppspdllldfleavreale......dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflyda

VQHYIQTLIARKRAEEQSLQV
...|... . .. | |. | .
lleylkrkltlepaselklkl
0051299 (Phosphotyrosine protein) phosphatases II 543-746 5.5e-70 231.4 In-house 92-286 (288) alignment 
Range on Protein: 543-746
Range on HMM: 92-286/288.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-----RDQPARRIFH
...|||||.|     ||| |||.|||..|.||||| ||..|.|.||||.|||. | |...|. .. ..|| . .|||.|.. |.       |.  |.. |
rkfIatqgPl....pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvth

YHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKF
.|.  ||||||| .|  .|.||..|.. ..       ..||..||||||.|||||||..|..|.|. ..    ..|. ......|.|| |.|||. ||.|
fhytnwpdhgvpdspellldflrlvrkala......sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrf

VYYAVQHYI
||.|. .|.
vyealleyl
DSPc_SM00195 542-747 1.8e-68 226.1 In-house 68-263 (263) alignment 
Range on Protein: 542-747
Range on HMM: 68-263/263.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDE-GRSEQFGHARIQCVSENSTS-DYTLREFLVSWRDQ-PARRIFHY
 |.||||||.|     .|| |||.|||.|....|||.|.| |.|||||.||||.| |..|.||. ....|...... ...||.. ..  ..  .|.. .|
kkkyIatQgPl....pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagekPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFV
... ||||||| ..  ||..|. |....|.        |||.||||||.||||||..||.||... ..     .||. .....|.|| |.|||..||.|.
qyknWpdhgvpdstksvlellravkksksts......sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfi

YYAVQHYIQ
| |. .||.
yeaileyik
PTPc_SM00194 542-747 1.8e-68 226.1 In-house 68-263 (263) alignment 
Range on Protein: 542-747
Range on HMM: 68-263/263.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDE-GRSEQFGHARIQCVSENSTS-DYTLREFLVSWRDQ-PARRIFHY
 |.||||||.|     .|| |||.|||.|....|||.|.| |.|||||.||||.| |..|.||. ....|...... ...||.. ..  ..  .|.. .|
kkkyIatQgPl....pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqy

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagekPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFV
... ||||||| ..  ||..|. |....|.        |||.||||||.||||||..||.||... ..     .||. .....|.|| |.|||..||.|.
qyknWpdhgvpdstksvlellravkksksts......sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfi

YYAVQHYIQ
| |. .||.
yeaileyik
0047943 (Phosphotyrosine protein) phosphatases II 542-746 8.9e-68 224.0 In-house 76-272 (273) alignment 
Range on Protein: 542-746
Range on HMM: 76-272/273.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGR--SEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHY
 ...||||| |     ||| |||.|||..|.||||| |...|.|.||||.|||.||   |...|. .. ..||.. .|||.|.. ...  ..  | . |.
krkfiatqgPl....pntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthf

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAgekpGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFV
|.  |||||||...  .|.|...|.. ...| .     ||..||||||.|||||||..|..|||. ..|   ..|.  .....|||| | |||. ||.|.
hytgwpdhgvppslesllefielvrkalealpsn....gpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrfl

YYAVQHYI
|.|. .|.
yealleyl
0045450 (Phosphotyrosine protein) phosphatases II 543-746 2e-67 223.4 In-house 107-304 (307) alignment 
Range on Protein: 543-746
Range on HMM: 107-304/307.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSW--RDQPARRIFHYHF
...|||||.|     .|| |||.|.|.....|||| |.. |.|.||||.|||||| . ..|. .. ..||.  ..||.| . |.    ... |.. |.|.
rkfIatqgPl....petvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

QVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  ||||||| ..  .|.|.. |.. ...|     |.||..||||||.|||||||.....|.|. ..|  . .|.. .....|.||.| ||.. ||.|.|.
tgwpdhgvppsfeelldfieevrkaleel....pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye

AVQHYI
|.....
allell
0043336 (Phosphotyrosine protein) phosphatases II 542-746 1.2e-64 213.8 In-house 87-277 (278) alignment 
Range on Protein: 542-746
Range on HMM: 87-277/278.0
FKTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPdeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHYHF
 ...|||||.|      || |||.|||......||| |.. |.|..|||.|||  | |...|. .. ...|.. .|||.| . |.  .| . | . |||.
prkfiatqgPlpe....tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhy

QVWPDHGVPADPGCVLNFLQDVNTRQShlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  ||||||| ..  .|.||..|.....       ..||..||||||.|||||||.....|.|. ..|   ..|.. .....|.|| | |||. ||.|.|.
lgwpdhgvpeslsllldflkavreale......dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflye

AVQHYI
|...|.
alleyl
Y_phosphatase Protein-tyrosine phosphatase 543-743 1.1e-62 207.0 Pfam-A 42-234 (235) alignment 
Range on Protein: 543-743
Range on HMM: 42-234/235.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWP-DEGRSEQFGHARIQCV-SEN-STSDYTLREFLVSWRDQPA--RRIFH
|..|||||.|     .|. ||| |||||...|||| |.. |.|.||||.||| .|..|...|. ..... .|.  ...||||.. .. ....   |.. .
kkfIatQgPl....kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkq

YHFQVWPDHGVPADPGCVLNFLQDVNTRQshlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKF
.|.. |||||||..|  .|.....|....       .| ||..||||||.||||||...|..|.|. ...    .|.  .....|.|| |.||...||.|
lhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYif

VYYAVQ
.| |..
lykail
Y_phosphatase Protein-tyrosine phosphatase 543-743 1.1e-62 207.0 In-house 42-234 (235) alignment 
Range on Protein: 543-743
Range on HMM: 42-234/235.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWP-DEGRSEQFGHARIQCV-SEN-STSDYTLREFLVSWRDQPA--RRIFH
|..|||||.|     .|. ||| |||||...|||| |.. |.|.||||.||| .|..|...|. ..... .|.  ...||||.. .. ....   |.. .
kkfIatQgPl....kstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkq

YHFQVWPDHGVPADPGCVLNFLQDVNTRQshlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKF
.|.. |||||||..|  .|.....|....       .| ||..||||||.||||||...|..|.|. ...    .|.  .....|.|| |.||...||.|
lhytnWpdhgvpespkslldlirkveksk......eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYif

VYYAVQ
.| |..
lykail
0040439 (Phosphotyrosine protein) phosphatases II 543-746 2.1e-62 206.3 In-house 54-246 (249) alignment 
Range on Protein: 543-746
Range on HMM: 54-246/249.0
KTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHYHFQ
...|||||.|      || |||.|.|... .|||| |.. |.|.||||.|||. | | ..|. .....|... .|||.|.. ..   |.. |.. |... 
rrfiatqgPlpe....tvedfwrmlwelgitvivmLtslvelgrekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqyt

VWPDHGVPADPGCVLNFLQDVNTRQSHLaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 ||||||| ..  .|.|.. |.. ...|    .|.||..||||||.|||||||.....|.|. ..    ..|.. .....||||.| ||.. ||.|.|.|
dwpdhgvppsfedlldfieavrkaleel....pkggpvlVHCsaGvgRtGtfiaaylmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyea

VQHYI
.....
llell
subfamily_PTPRB_pd Subfamily PTPRB 541-747 3.2e-62 205.2 In-house 92-286 (293) alignment 
Range on Protein: 541-747
Range on HMM: 92-286/293.0
MFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWrDQPARRIFHYHF
. . .||||| |     .|| |||.|||......||| |.  |.||.|| .|||.. .. ..|. ... |.|....|...||....  ..  |.. .|||
sprefiatqGPl....petvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhf

QVWPDHGVPADPGCVLNFLQDVNTRQSHlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
. ||||||| ..  .|.|.. |......     .. .|| ||||||.||||||| .|..|..| .   .  .||  ... .|..|  |||||.|| |.. 
tsWpdhgvPektktlldfvrtvreaiek....taskrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihq

AVQHYIQ
.|.....
cvldllr
0045098 (Phosphotyrosine protein) phosphatases II 543-747 1.8e-61 203.3 In-house 64-273 (278) alignment 
Range on Protein: 543-747
Range on HMM: 64-273/278.0
KTYIATQGCLLtqqvNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-----RDQPARRIFH
|..|||||.|     .|| |||.|.|.....|||| |...|.|.||||.|||. | |...|. .. ..||  ..||||| .||        | . | ..|
kkfIatqgPlp....stvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvth

YHFQVWPDHGVPADP--GCVLNFLQDVNTRQSHLAQAG-------EKPGPICVHCSAGIGRTGTFIVIDMILDQIvrnglDTEIDIQRTIQMVRSQRSG-
.|.  ||||||| .|    .|..|. .. ....||.         ...||. ||||||.|||||.......|...     .  .|.. .....|||| | 
lhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpgl

LVQTEAQYKFVYYAVQHYIQ
 ||.. ||.|.|........
avqnleqyrflyefllelll
0042113 (Phosphotyrosine protein) phosphatases II 542-746 2.9e-61 202.3 In-house 51-243 (245) alignment 
Range on Protein: 542-746
Range on HMM: 51-243/245.0
FKTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHYHF
 ...||||| |      || |||.|.|... ..||| |.| |.|..|||.|||. | | ..|. .....||.. .|||.|.. |.  .| . | ..|||.
tpkfiatqgPlpe....tvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhy

QVWPDHGVPADPGCVLNFLQDVNTRQSHlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  ||||||| ..  .|.||. |.. ..       ..||..||||||.|||||||.....|.|. ...   ..... .....||||.| |||. ||.|.|.
lpwpdhgvpdllellldflefvrkalae.....dsngpvlVHCsaGvgRtGtfiaaylmleqlekel...gvsleeavkelrsqRpgavqtpsqyrflye

AVQHYI
|.....
allell
0037934 (Phosphotyrosine protein) phosphatases II 541-746 6.2e-61 201.3 In-house 42-242 (243) alignment 
Range on Protein: 541-746
Range on HMM: 42-242/243.0
MFKTYIATQGCLLTqqvnTVTD----FWNMVWQENTRVIVMTTKEYERGKEKCARYWPdegRSEQFGHARIQCVSENSTSDYTLREFLVSW--RDQPARR
.....||||| |      || |    ||.|.|.....|||| |...|.|.||||.|||    ....|. .....||....|||.|..|...   |.. | 
vtprliatqgPlpe....tveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gevtygdftvtllseehlddytvrtlllenldlddltrl

IFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQ--AGEKPGPICVHCSAGIGRTGTFIVIDMILDQIvrngldtEIDIQRTIQMVRSQRSG-LVQT
..|||.  ||||||| .|  .|.||..|.. .. | .  |  . ||..||||||.|||||.|.....|...       ..|.. .....|.||.|  |||
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.......gvdleeavkllreqRpgkavqt

EAQYKFVYYAVQHYI
. ||.|.|.|.....
psqyrflyeallell
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 543-757 1.7e-60 199.7 In-house 89-291 (318) alignment 
Range on Protein: 543-757
Range on HMM: 89-291/318.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARR-IFHYHFQ
|.|||.|. |     .|..||| |||. |..|||| |.| ||||.|..||||..| |...|. ...  .| ..|||.|||| |. ... . | .  ||. 
kayiaaqaPl....petieDfWrmvWeqnsavivmltqeeergkakvhryWPskg.srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhyt

VWPDHGVPADPGCVLNFLQDVNTrqshlAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||.|||.... .|.....|..     ||. .. ||| ||||||.||||.||..|..|..|  ..|   .|.  |....|.||  .|||| ||.|.| .
sWpdegvpesgaslldlvrqvsk.....aqqksgagpivvhCsaGvGrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqtedqyefiydv

VQHYIQTLIARKRAEE
.. ....  .   |..
llealasgdtevdasd
subfamily_PTPN12_pd Subfamily PTPN12 542-753 2.3e-60 199.0 In-house 82-284 (290) alignment 
Range on Protein: 542-753
Range on HMM: 82-284/290.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQ-FGHARIQCVSENSTS-DYTLREFLVSWRdQPARRIFHYH
 ..|||.|| |     .|..||| |.|. |....||  .|.| || ||.||||.|| .|  ||. .... .|. .. |...| . |  . .  |..  .|
kleyiaaqgPL....pktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfh

FQVWPDHGVPADPGCVLNFLQDVNTRQShlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
.. |||||||. .  .|.....|...|.      ..  |..||||||.||||| |.||.. ... .. .. |.|.   .. .| ||. ||||. ||..||
YtaWPDhgvPssaksllelielvrelqe......sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvy

YAVQHYIQTLIARK
 || ...|. .. .
kavaelvqkeleii
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 512-748 8.6e-59 194.2 In-house 73-292 (298) alignment 
Range on Protein: 512-748
Range on HMM: 73-292/298.0
VGLLKRHSNDSSGAVSISMAEREREREremfkTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVS
| | | .... |  .  | ..  ..|.     ..||||. |    ..||.||| ||..|.  .||| |.  | .| |. .|||||| .|..|. ...  |
vvLekedadeesdYiNAsflhaykgrn.....afiatqaPl....tetvedFWrmvteedigtiVmltnleeldktkyhkywPdeg.ketygeitvslls

ENSTSDYTLREFLVSWRD-QPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRnglDT
... .|.. |.. || .. .  |.. . || .|||.|||.    ||..|..|.. |.   |||.|  |. |.||||.||.||||.|| .|... .   . 
keefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqq...qagnk..pvivqCsaGvgRsGtfiaidsvlervkk...eq

EIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQT
 .|. ......| .| |.||||.||.|.|.||......
vvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_PTPN9_pd Subfamily PTPN9 543-748 1.8e-58 193.0 In-house 85-292 (297) alignment 
Range on Protein: 543-748
Range on HMM: 85-292/297.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWP-DEGRSEQFGHARIQCVSENSTSDYTLREFLVS-WRDQPARRIFHYHF
|..||||| |     .||.||| |||.....||||||.  |||. ||..||| .|. |..||. ... |. ....||. | . ..  ...  |.. |. |
kafiatqGpl....kktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqf

QVWPDHGVPADPGCVLNFLQDVNTRQSHLAQA------GEKPG-PICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEA
  |||.||| .   .|..|. |  .|. ....      |.  | || |||||||||||||| .|. |... . |    .|.. |....|.||.  .||. 
lsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg...tvdvvetvkllrtqrafsiqtpe

QYKFVYYAVQHYIQT
||.| | ||  | ..
qyefcylavleyale
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 542-744 3.6e-58 191.9 In-house 89-277 (288) alignment 
Range on Protein: 542-744
Range on HMM: 89-277/288.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSwRDQPARRIFHYHFQ
 |.|||||| |     .|| |||..|....|  ||| |.  |.||.|| .||||... ...|.  .. |... . |..||..|.  ...  ..| .|...
kkkyiatqgPl....adtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqyl

VWPDHGVPADPGCVLNFLQDVNTRQSHLaqagekPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
.|||||||..   .|..|. |.. ..         ||| ||||||.|||||||..|...|.. .   .  ||.  |.. .| ||  ||||. || |.| .
aWpdhgvPeskapllellrqvkvanqad......tgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyev

VQH
. .
lls
subfamily_PTPRA_pd Subfamily PTPRA 543-746 4.7e-58 191.6 In-house 101-295 (330) alignment 
Range on Protein: 543-746
Range on HMM: 101-295/330.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVSENSTSDYTLREFLVS-----WRDQPARRIFH
...||.|| .     .|| ||| |.|. ..  ||| |.  || .||||.|||||| .  .|. |..   |. . |||.|.|||       |....| .  
dkfiaaqGPk....eetvedfwrmiweqksativmltelkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrq

YHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAqagekpGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKF
.||. ||| |||..|  .|..|. |.. .   |      ||| ||||||.||||||||.| .|...     .  .|. .... .| ||. .|||. ||.|
fhftswPdvGvPfepiGmlkllkkvkklnqqsa......gpivvhcsaGvGrtGtfivldavlervka...erkvdvfefvkrlrlqrpqmvqtdeqyef

VYYAVQHYI
.| ....| 
iykvlleyy
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 543-748 5.2e-58 191.6 In-house 91-285 (319) alignment 
Range on Protein: 543-748
Range on HMM: 91-285/319.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPA--RRIFHYHF
. .||||. |     ||. ||| |||.|.. ..|| ||  |..| |. .|||.|   |..|.  ..  .|. ..||  |.. .  . .    |...|...
ekfiatqaPl....entiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqy

QVWPDHGVPADPGCVLNFLQDVNTrqshlAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
. ||||.|| .   .|..|....      .. ... ||| ||||||.||||||||.|..|... ..|.   .|.  |....| ||  .||...||||.|.
teWpdhdvPekatslldllkrirk.....srektqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiye

AVQHYIQT
|. .....
alleavea
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 543-749 8e-58 191.0 In-house 89-286 (305) alignment 
Range on Protein: 543-749
Range on HMM: 89-286/305.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-EQFGHARIQCVSENSTSDYTLREFLVSW--RDQPARRIFHYH
|.||..|| |     |||.|||.....| ...||| ||  | ||.|| .|||.. .  ..||.  ..  ||...|||. |.. .|    |.  | . .|.
kkyivaqgPl....kntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyq

FQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
.  |||||||  .. .|.....|. .|..     .|  |. ||||||.||||.||..|. |... . .   ..|. . .. .||.| ..||| .|| |..
ltdWPdhGvpqfatsllslikrvqkdqkk.....dkgvpllVhCsagvgRtGvfiavdialerlkkEe...vvdvfevlkqlRskrmkmvqtldqYvflh

YAVQHYIQTL
 |.. .|.. 
daldelitcg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 541-749 2.2e-57 189.2 In-house 71-271 (274) alignment 
Range on Protein: 541-749
Range on HMM: 71-271/274.0
MFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS---EQFGHARIQCVSENSTSDYTLREFLVSWRDQpARRIFH
  |.|.|||| |    .|||.|||.|..||...||||.||  |. ..|||.|.||.      |..|.  |. .. ... ||..|.....   .  |.. |
eskayvatqGPl....pntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkh

YHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKF
| .  |||| .| |.  .|.....|.. ..   .. .| .|. ||||||||||| || |.. . |. .   .. .|. ...  .| .| |.|||. ||..
ywytdWPdhksPddantlldlvleveesre...eenaklapvvvhCsaGiGrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyel

VYYAVQHYIQTL
.. |. .| . |
ihralclylkrl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 543-748 4.5e-55 181.7 In-house 84-278 (281) alignment 
Range on Protein: 543-748
Range on HMM: 84-278/281.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFHYHFQV
| |||||| .     .....||.|||... ..||| |.| | || || |||||.  . ..|. ... ..|.... |  |.| .. .. ..|.. . ... 
keyiatqgPv....PaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleresgetreveqlayta

WPDHGVPADPGCVLNFLQDVNTRQSHLAQagekpGPICVHCSAGIGRTGTFIVIDMILDQIVRNglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
||||||||..  .|.| ..|.  ...  .      |...|||||.|||||.| .| ..... ..   .|.|.. ... .| .|  .||| .||.||| ||
WPdhGvPattkellefrkevlkltekktk.....aplvihCsaGvGrtGtyialDrlvkaveae..leeldvkavvaelrkernlmvqtvvqyefvykav

QHYIQT
 .... 
ldaldk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 540-748 6.2e-55 181.1 In-house 50-244 (250) alignment 
Range on Protein: 540-748
Range on HMM: 50-244/250.0
EMfKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEkCARYWPDEgRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPAR-RIFHY
|  |..||||| |    ..|. ||| ||..|.. .||| |.  | .|. . .||| | ..|..|. ...  |..  .||| |.. .| . .  .  . ..
er.kafiatqgPl....qatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve.kaekyGdvtvsllskeefadytkrklklskakkaderivrql

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqAgeKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
|| |||| |||.   .||..|..|.. | .   |  . .|. |.||||.||.|.||.|| .|... .   .  .|. . |...| .| . |....|| ||
hfvvWPdkgvPevatavLellkkvqasqqq...a..gnaPvivqCsaGvgrsGafiaidavlerlkk...ekvvdvfkvikvlrkdrphavesleqyvfv

YYAVQHYIQT
| ........
yeiilkalds
subfamily_PTPN3_pd Subfamily PTPN3 540-743 1.1e-54 180.3 In-house 81-272 (280) alignment 
Range on Protein: 540-743
Range on HMM: 81-272/280.0
EMFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRD-QPARRIFHY
.. . |||||| |     .|.||||.|||......||| |   |||. || .|||... . ..|. ...| .|..|. | |||.... .. .  |.|.. 
glvnryiatqGPl....aktatdfWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilql

HFQVWPDHGVPADPGCVLNFLQDVNTRQshlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
 .  ||||||| |.  .|.|.. |.. .        |  |. ||||||||||| .|.... |  | ..    .. .   ....| ||. ||||..|||||
qylaWpdhgvPddsadflefvervrklr......sgkeePvvvhCsaGigrtGvlilletalalieaa...epvypldivrtmrdqramlvqtasqykfv

YYAVQ
  |. 
Ceail
subfamily_PTPN1_pd Subfamily PTPN1 540-749 2.3e-53 175.8 In-house 68-274 (290) alignment 
Range on Protein: 540-749
Range on HMM: 68-274/290.0
EMFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGR--SEQFG--HARIQCVSENSTSDYTLREFLVS-WRDQPARR
|. . || ||| |    .|||. ||.|||..... .||  |  |... |||.||| . .  . ..   . ... .||...| ||.| . .   . | .| 
eakrsyiltqGPl....pntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetre

IFHYHFQVWPDHGVPADPGCVLNFLQDVntRQSHLAqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQ
|.|.|.  ||| |||  |.  |.||..|  |.|      .. ||  .||||||||.|||...| .| .| ...  . .||....  .|..| ||.||  |
ilhfhyttwpdfgvpespaaflkflfkv..resGsl..ssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadq

YKFVYYAVQHYIQTL
 .| | |. . ....
lrfsylaileGakvi
subfamily_PTPN13_pd Subfamily PTPN13 544-748 8.8e-53 174.3 In-house 78-271 (273) alignment 
Range on Protein: 544-748
Range on HMM: 78-271/273.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHA--RIQCVSENSTSDYTLREFLVSWR-DQPARRIFHYHF
.|||.|| |     .||.||| |||. ...||.| |.| |.|| || ||||.. ...   .   ... .  .  .....|.. |.    . .|.. | .|
eyiacqGPl....PetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnf

QVWPDHGVPADPGCVLNFLQDVNtrqsHLAQageKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  |||||||. .  .|.|.. |.    .|..   . ||| |||||||||.||.|.||..|. | |.    |.|.. ... .| || |.|||. || ||| 
vkwPdhgvPssaaellqfvaevr....rlqt...dagPivvhcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvyk

AVQHYIQT
|. . ...
ailevlks
subfamily_PTPRG_pd Subfamily PTPRG 543-751 3.1e-52 172.5 In-house 91-292 (563) alignment 
Range on Protein: 543-751
Range on HMM: 91-292/563.0
KTYIATQGCLLtqqvNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDeGRSEQFGHARIQCVSENSTSDYTLREFLVSW-----RD--QPARRI
| .||||| |     .|. ||| |.|..|. .||| |.  |||..|| .|||    ||..|. ... ..|. .. || |.. .        .  .  ...
kafiatqgplk....dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklv

FHYHFQVWPDHGVPADPGCVLNFLQDVntrqshLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQY
 .||.  |||||||  .  ||.| .         |   .. ||| ||||||.|||||.||.| .| || ..     ... ......|.||  ||||| ||
rqyhytkWPdhgvPehslpvLifvkks......saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqe...navnvfgflkhiraqRnflvqteEqY

KFVYYAVQHYIQTLIA
 |.. |..  |..   
iflhdalleaiasket
subfamily_Ptp69D_pd Subfamily Ptp69D 542-747 2.5e-51 169.7 In-house 90-287 (307) alignment 
Range on Protein: 542-747
Range on HMM: 90-287/307.0
FKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgRSEQFGHARIQCVSENSTSDYTLREFLVSWRD------QPARRI
.|..|| |. .     .|. ||| |... .  .||| ... |  ..|||.|||.|    |.|.  ...|||...|||. ||. ||  .      .  |..
kkkfiaaqdPv....eatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkv

FHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLaqagekPGPICVHCSAGIGRTGTFIVIDMILDQIVrngLDTEIDIQRTIQMVRSQRSGLVQTEAQY
  ||.. |.|  ||  .  .|.... |.  ...        .|| |||||| ||.|.|. .|..|.|.    .. ..||  |.. .||||. |||  .||
vqyhytgWkDskvPevargllklieqvrelykln......rsPivvhCsaGvgrsgifvaldsllqqlk...aedkvdifetvkdLrsqRnllvqsleqY

KFVYYAVQHYIQ
.|.| |.  |..
vflyralldyss
subfamily_PTPN14_pd Subfamily PTPN14 543-747 5.2e-51 168.4 In-house 93-297 (300) alignment 
Range on Protein: 543-747
Range on HMM: 93-297/300.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEG---RSEQFGHARIQCVSENSTSDYTLREFLVSW-RDQPARRIFHY
..||..|| |     .||.|||.|||......||| |.| | ||||. .|.|...   .. .||. ...    .... .. . . . .   .  | ..| 
rsyivaqgPl....eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhl

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAG---EKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQY
 .. ||||||| |.   |..|..|.  . .  .     |.  |. ||||||.||||  |. |...  .  |    ||||.......| ||  |||| |||
qytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn...eeidikkvlarLreqrmllvqtlaqY

KFVYYAVQHYIQ
|||| .. .|..
kfvYkvlikylk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 543-751 1e-50 167.3 In-house 64-269 (270) alignment 
Range on Protein: 543-751
Range on HMM: 64-269/270.0
KTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS---EQFGHARIQCVSENSTSDYTLREFLVSwRDQPARRIFHYH
|.|||..| | |    |...|| |.|.|... |||||.  |.|..||.|||| |  .    ..|. ..  .||. .. | |..  .  ..   ||. |..
kkYiaamgPlpt....tlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfw

FQVWPDHGVPADPG------CVLNFLQDVNTRQSHLAQAGekpgPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEA
.. ||||||| ...       .|. |..|   ...|..|.    |. ||||||.|||||.|..|...  . ..   ...|. . |. .| .|  |||.  
yntWpdhgvpreedsslstdqllkmlravrrsekeldkae....PllvHcsaGvgRtGtlialDiavrlLeet...kkvdvlaiieelRkdRmalvqhpe

QYKFVYYAVQHYIQTLIA
||.|.| ||..|.... .
qyeflykavveyaerrak
subfamily_PTPRK_pd Subfamily PTPRK 543-742 4.2e-50 165.4 In-house 86-273 (314) alignment 
Range on Protein: 543-742
Range on HMM: 86-273/314.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSeqFGHARIQCVSENSTSDYTLREFLVSW--RDQPA-RRIFHYH
. .|.||| |     .||.||| .|..||.  ||| |.  | |. || .|||....   .|. ....|. .  ...  | | |.   | | . | . ...
aafivtqgPl....qetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfq

FQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqageKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVY
|  ||||.||     .|.... |.. | .      . |.| |||||| |||||||.||..|| | |.|.   .|.  ... .||... .|.|| ||||.|
flgWpdhdvPvsatgllklvrrvkksqee......eaGrivvhCsaGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiy

YAV
 ..
dvi
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 543-750 4.3e-50 165.4 In-house 87-284 (315) alignment 
Range on Protein: 543-750
Range on HMM: 87-284/315.0
KTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFlVSWRDQPARRIFHYHFQ
|.|||.|| | .    .| |||.||.||..  ||| ||  |  | ||..|||| .. | .||  ... .| ....| . |.. |  . .  |..  ..|.
kayiasqgPlka....svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqft

VWPDHGVPADPGCVLNFLQDVNTRqsHlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||.||. . . .|.....| .   .    |.|  .. ||||||.|||| .| || ...|| |.     .|. ......|..|  ||||| .| |.| |
ewPdkGvdkqtssllklikevkad..n....gkkefsllvhcsaGvGrtGvvisidevvaqikrt...rsvdvfnfvknlrakrpylvqteeeyafiyda

VQHYIQ---TLI
|. ...   |||
vledllwrntli
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 543-750 6.7e-50 164.6 In-house 86-283 (515) alignment 
Range on Protein: 543-750
Range on HMM: 86-283/515.0
KTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQpARRIFHYHFQ
|.|||.|| . .    .| |||..|.|||.  |.| ||  |  | ||..||||  | | .||. ... || .. .. . |.. |   |. .| .  .||.
kayiasqgPnka....svddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhft

VWPDHGVPADPGCVLNFLQDVNTRQSHLAQagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||.||| .  ..| ....| . .....       |. .|||||.|||| .| || .. ..        .|. .... .| .|  ||||. || |.| |
eWPdkGvpkhtssllklikevkadhgqyth......pliihcsaGvGrtGvvisidsvvahaktt...rmvdvfnfvtnirqkrpylvqtqeqyafiyga

VQHYIQ---TLI
|. ..    |||
vledllwrntli
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 544-742 1.1e-49 164.4 In-house 105-287 (319) alignment 
Range on Protein: 544-742
Range on HMM: 105-287/319.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTkeyergKEKCARYWPDEGRsEQFGHARIQCVSENSTSDYTLREFLVSW--RDQPARRIFHYHFQ
 |||.|| |     ||. ||| |.|. |.  ||. |      |.||..||| ..  .. ..  ..  | . |..|..|.. .|   . .  |.|  .||.
kyiaaqGPl....dntladfWrmiweyncstivllt......kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhfl

VWPDHGVPADPGCVLNFLQdvntRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||.|||  |  .. ...    . .|| .  ... .| ||||||.||||..||.|..||.. .   .  .|. .... .| ||. |||  .||||.| |
GwpdvGvpdypsdlmrlvk....kvrhltskenhranivvhcsaGvGrtGvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysa

V
.
l
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 544-743 5e-49 162.3 In-house 69-252 (284) alignment 
Range on Protein: 544-743
Range on HMM: 69-252/284.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTkeyergKEKCARYWPDEGRsEQFGHARIQCVSENSTSDYTLREFLVSW--RDQPARRIFHYHFQ
 |||||| |     ||. ||| |.|. |.  ||. |      |.||..||| ..  .. .. ...  | . ...|..|.. .|   . .  |.|  .||.
kyiatqGPl....dntladfWrmiweyncstivllt......kdkcsqywplkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhfl

VWPDHGVPADPGCVLNFLQdvntRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||.|||  |  .. ...    . .|| .  ... .| ||||||.||||..||.|..||.. .   .  .|. .... .| ||. |||  .||||.| |
gwpdvgvpdypsdlmrlvk....kvrhltskenhranivvhcsagvgrtgvyivldvlldrmke...ekqvdvynfvrdlrqqrntlvqdlvqykfiysa

VQ
. 
ll
subfamily_PTPN23_pd Subfamily PTPN23 545-749 3.5e-48 158.9 In-house 85-283 (288) alignment 
Range on Protein: 545-749
Range on HMM: 85-283/288.0
YIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWP-DEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPA-RRIFHYHFQV
.||||.     . .|. ||| ||... ..|||| ... |.||.|..|||| |.|....||. .. . |...|. .  |.. .. .|. | . . | ... 
fiatqaP....lqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqlts

WPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQI-VRNGLDteiDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
||..|||| |. .|.||. |..  ..  .  ..  |. ||||||.||||.| ..  .. .. ..|||    || . .. .| ||   ||...|.||.| |
WpelGvPasPetllqfldevesayeavqrkskt..PlvvhCsaGvgRtgvfalvyaavrelekgngll...diiqvvsrlreqRrfmvqekeqlkfsyea

VQHYIQTL
| ....  
vleaarrv
subfamily_PTPRN_pd Subfamily PTPRN 543-749 1e-47 157.3 In-house 100-295 (297) alignment 
Range on Protein: 543-749
Range on HMM: 100-295/297.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVSENS-TSDYTLREFL-VSWRDQPARRIFHYHF
 .|||||| |     .||.|||.|||.. . |||. |.  | | ..|.||||||| || ..   .. |||   . || .| |     . . .| .  .||
payiatqgpl....astvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG.sevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhf

QVWPDHGVPADPGCVLNFLQDVNTrqSHlaqAGeKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnGLdTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  ||..|||| .  .|.| . ||   |.    | .  || ||||.| ||||..|.||..|..... |.  ||||  |.. .| ||.|||.|..|..|.. 
lswpeegvPasaksllefrrkvnk..sy...rG.rscpivvhcsdGaGrtGvyilidlvlnrllk.Gv.keidiaatlehlrdqrpglvktkdqfefalt

AVQHYIQTL
|| . ....
avaeevnai
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 543-749 2.6e-46 152.8 In-house 91-286 (290) alignment 
Range on Protein: 543-749
Range on HMM: 91-286/290.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQ--PARRIFHYHF
| |||||| .     ||. |||...|||.. .||| |.. | ||.||  ||||.  ....|. .|. ..|.....|. |.. |  ...  ... . .|..
kqyiatqgpv....sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqi

QVWPDHGVPADPGCVLNFLQDVNTRQSHlaqAGekPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
. |...|  ..|  .|  .. ..  | .    |   ..| ||||...||...|..... ...   .|    ||.   ..  |.|. |.|||. ||.....
tnwdstgkvtnpqtillvieemyktqrk...rg..ntsivvHCSdtvgrsavfcaaattinkckteg...vidvfqvlksqRiqkpgsvqtvqqyqgifq

AVQHYIQTL
 | .|....
ivltyldsf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 543-741 9.5e-46 150.9 In-house 45-234 (237) alignment 
Range on Protein: 543-741
Range on HMM: 45-234/237.0
KTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWR--DQPARRIFHYHF
|.|||.|| | .    .  |||.|||||.  |||| |   |. ..|| .|||.  . . .|   .    ..  ||||.| .|.| |   .  | |. |.|
kkyiaaqgples....scddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqf

QVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAgekpGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
 .|||.|||     .| | ...  |  |....    ||  .|||||.|||| |.||| .| |   .     .||   .. .  .|  ..||. || |.. 
tswpdrgvpqqtaallrfrkniinrsphvses....gpwiihcsagvgrtgiflvidamlrqakek...kvvdiynyvysieedrpyiiqtkdqyvfihq

A
.
t
0051429 (Phosphotyrosine protein) phosphatases II 545-753 9.6e-46 151.9 In-house 24-232 (272) alignment 
Range on Protein: 545-753
Range on HMM: 24-232/272.0
YIATQGCLLTqqvnTVTDFWNMvWQENTRVIVMTTKEYERGKEKCARYWP-----------DEGRSEQFGHARIQCVSENSTSDYTLREFLVSWR---DQ
.....|.|      |. ||| . .... ..||. ..|.|||..|| ||||           |.  .  .|. |. ..||  ..||.|||.|...    ..
lyrsggplpl....taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsage

PaRRIFHYHFQVWPDHGVPADPgcVLNFLQDVNTrqshlaqagekPGPICVHCSAGIGRTGTFIVIDMILdqiVRNGLDTEID--------IQRTIQMVR
. |...|.|.. ||||||| ..  .|..|. ...           .||. ||||||..||||.......|    . .|.| .|        ........|
a.revmhlhytdwpdhgvpqea..llellellld...........ggpvlvHCsaGkdRTGtvvalllll...lgvsletivddYlltnlyleeaveelr

SQRSGLVQTEAQYKFVYYAVQHYIQTLIARK
.|| | ||||.||.|.| |..... .|....
aqrpgavqteeqylflyeallellrsllsvr
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 556-747 6e-45 148.6 In-house 101-285 (297) alignment 
Range on Protein: 556-747
Range on HMM: 101-285/297.0
QVNTVTDFWNMVWQENTRVIVMTTKEYERGKeKCARYWPDEGRSEqFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIF-HYHFQVWPDHGVPA--DP
. .|| ||| ||..|.. .||| ... || | ||||||.|.| .. ||.  ..  | .. . .  ||. |.  .  |||.   |.|  |||. |.   . 
mkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsa

GCVLNFLQDVntRQSHLAQAgEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQ
  .|.....|  |...  .| |   |. |||.||.|||| .. || .. .. |.    |.||  .....| .|  ||||. |||||| ||  .. 
ssllklisev..rkdfsqna.eg..PllvhclaGvGrtgvlltidsvvaeakre...kevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 543-742 4.6e-44 145.6 In-house 92-275 (315) alignment 
Range on Protein: 543-742
Range on HMM: 92-275/315.0
KTYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgrSEQFGHARIQCVSENSTSDYTLREFLVSWRDQpARRIFHYHFQV
. |||.||     .|..| ||| .|..|.   ||| |.  |. |.|. .||||.     .|.  .  .||.  ..|| | . |  .|.  | .. .|.  
rryiaaqgp....nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdn.irevvqlhyts

WPDHGVPADPGCVLNFLQDVNtrQSHLAQAgekpGPICVHCSAGIGRTGTFIVIDMILDQIvrnGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
||| |||.    ..|. . |.  | | ...    |.| ||||||.||||||| .| .|||.     .  ||. . |. ||..| ..||. .||.|.| |.
wpdmgvpkytiplmnlirtvk..qhhtnsv....gaivvhcsaGvGrtGtfitldavldqa...eaenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 543-746 3.1e-43 143.1 In-house 91-288 (325) alignment 
Range on Protein: 543-746
Range on HMM: 91-288/325.0
KTYIATQGCLltqqVNTVTDFWNMV--WQenTRVIVMtTKEYERGKEKCARYWPDE-GRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQP-ARRIFHY
....|.|  |     .|. |.| .|  |.  . |.|. . | . ||..|| |||.| | | .||  ... .. .  |||  | . |   ..  .| .  .
dvflaaqaPl....tatindlWrlvldWr..csvvvv.lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqf

HFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
..| |.| ||.  | .....|| |.. .  .    .  .|| ||||||.||||.|| .  .|....    ....||   .. .| .|  .|.|  || ..
qlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvie...esrvdifgfvkklrkdrpsmvetvdqyili

YYAVQHYI
| |.  ..
yealveay
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 543-748 6.2e-43 141.8 In-house 86-280 (287) alignment 
Range on Protein: 543-748
Range on HMM: 86-280/287.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRsEQFGHARIQCVSENSTSDYTLREFLVSWR--DQPARRIFHYHF
| .|.... .    .||. .||......|  .||| ..| |  .|.| .|||.|     .|. .|. ..|. ...|. |.. |  .  ... ...  |..
kafiiaesPm....fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqi

QVWPDHGVPADPGCVLNFLQDVNTRQSHLAQagekpGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
  |...|  ..|  .|  ... .  | . ..     ..| ||||...||...|. ... ...  ..|    ||. . ..  | |. | ||| .||||.. 
tnWdstgkvtepqtillvieemyktqrkrgn.....tsivvhCsdtvGrsamfcaaattinkckteGv...iDvfqvlksqriqkpgsvqtveqykfind

AVQHYIQT
.|..|...
ivleylds
0036282 (Phosphotyrosine protein) phosphatases II 544-740 2e-41 136.9 In-house 18-164 (174) alignment 
Range on Protein: 544-740
Range on HMM: 18-164/174.0
TYIATQGCLLtqqvntvtdFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDegrseqfghariqcvsenstsdytlreflvsWRDQPARRIFHYHFQVW
 .||.||.|          || |..... ...|| ..|.|.|..|| .|||.                                |. . | ...|..  |
rliagqgpla.........fwemlkelgittvvmlleekelglykcinywpe...............................lredlerlgiqylylpw

PDHGVPADPGcVLNFLQDVNTRQSHlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQIVrnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
|||||| ..  .|.|.. |.. .|.      . ||. ||||||.|||||.......| ..      . .|. ......|.||.| |||. ||.|.||
pDhgvpdlsi.llefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 541-742 3.7e-41 135.9 In-house 49-236 (239) alignment 
Range on Protein: 541-742
Range on HMM: 49-236/239.0
MFKTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgrSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPA-RRIFHYH
  |.|||||||. .    .  ||| |.|||   |||| |   |  |.|| .||||   . ..   |.     .  .|| .| |..|   |   | ...||
spkayiatqgcvei....ssgdfwrmmwqerrcvivmltglieghkkkchqywpds..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyh

FQVWPDHGVPADPGCVLNFLQDVnTRQShLaqAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
| ||||.|||    .|| . . . |..| |   | .  |  .|||||.||||.|.||| .| |  ..     .||   .. .| .|  .|||  || |..
ftvwpdkgvpqyatavlglrrki.tkds.l..pgar..pwvihcsagvgrtgaflvidamlrqakkq...ktvdifnyvkairedrphmvqtseqyvfih

YAV
 ||
lav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 541-742 4e-41 135.8 In-house 50-237 (239) alignment 
Range on Protein: 541-742
Range on HMM: 50-237/239.0
MFKTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgrSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPA-RRIFHYH
  |.|||||||. .    .  ||| |.|||   |||| |   |  |.|| .||||   . ..   |.     .  .|| .| |..|   |   | ...||
spkayiatqgcvei....ssgdfwrmmwqerrcvivmltglieghkkkchqywpds..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyh

FQVWPDHGVPADPGCVLNFLQDVnTRQShLaqAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
| ||||.|||    .|| . . . |..| |   | .  |  .|||||.||||.|.||| .| |  ..     .||   .. .| .|  .|||  || |..
ftvwpdkgvpqyatavlglrrki.tkds.l..pgar..pwvihcsagvgrtgaflvidamlrqakkq...ktvdifnyvkairedrphmvqtseqyvfih

YAV
 ||
lav
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 518-742 4.3e-41 135.6 In-house 55-262 (283) alignment 
Range on Protein: 518-742
Range on HMM: 55-262/283.0
HSNDSSGAVSISMaererEREREMFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGrSEQFGHARIQCVSENSTSD
.|.|   || | .     ... .  | ||..|. |     .|| ||| ||..|.   ||| ||  |  ..||..||| .| ||..|   .    | .   
esrdyinavfipv.....sksykqdkkyiiaqsPl....drtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrG.sedyGeftvtlrkettsns

YTLREFLVSWR--DQPARRIFHYHFQVWpdhgVPADPGCVLNFLQDVNTRQSHlaQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQ
.. .|.|.      . .  . || .. |    .  ... ..| |  .|  .|   |  .| ||| ||||.|||||..|| .   ....  . .   .|. 
fiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvisl..qteskkgPivvhCstgiGrtavfiaasasvkdaltesv...vdvf

RTIQMVRSQRSGLVQTEAQYKFVYYAV
 .....| || ..|||  |||.|. .|
avvkimreqrmmavqtldqyklvhelv
0041856 (Phosphotyrosine protein) phosphatases II 542-747 1.7e-39 130.7 In-house 33-172 (182) alignment 
Range on Protein: 542-747
Range on HMM: 33-172/182.0
FKTYIATQGCLLTqqvnTVTDFWNMVWQENTRVIVMTTkeyergkekCARYWPdegrseqfghariqcvsenstsdytlreflvswrDQPARRIFHYHFQ
....||||| ||     || ||..|..... ..||. |         . .|||                                  .   | ...|.. 
atrfiatqgplls....tvadflrmlkelgittivnlt.........eelywp..................................ellerlgiqylyl

VWPDHGVPAdPGCVLNFLQDVNTrqshlaqageKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||||||  .  .|.|...|.           ..||. ||||||.|||||........ .        ..... ....|||.|.| |.|. || |...|
pwpDhgvpd.ldelldfieevle..........eggpvlVHCsaGvgRtgtlvaaylmkkl........gvsleeavklvrsrRpgmvitpnqyfflqla

VQHYIQ
. ....
llelll
0046846 (Phosphotyrosine protein) phosphatases II 550-747 1.4e-38 127.7 In-house 26-174 (176) alignment 
Range on Protein: 550-747
Range on HMM: 26-174/176.0
GCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDegrSEQFGHariqcvsenstsdytlreflvswrdqparrifHYHFQVWPDHGVP
..     ..|. ||. |..... ...|. |.|.| |. ||..|||.    |..|.                                .|..  |||||||
iatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi................................qylhlpwpDhgvp

ADpGCVLNFLQDVNTRQSHlaqaGekpGPICVHCSAGIGRTGTFIVIDMILDqivrnglDTEIDIQRTIQMVRSQRS-GLVQTEAQYKFVYYAVQHYIQ
 .   .|..|. .......    |   ||. ||||||||||||.......         .  .... ....||.||. | |||..||.|.|........
dl.elllellefirealke....g...gpvlVHCsaGigRtgtlvaayllel.......ekglsveealalvreqRplgavqtpeQyrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 544-744 2.3e-37 123.7 In-house 21-159 (172) alignment 
Range on Protein: 544-744
Range on HMM: 21-159/172.0
TYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEyergkekcarywpdegrseqfghariqcvsenstsdytlreflVSWRDQPARRIFHYHFQVW
 .|||||.      ||. |||.|..... ..||. |..                                           . ....  | ...|..  |
rfiatqgp....lrntladfwrmlkelgithivnltel...........................................lydpellerlgiqylylpw

PDHGVPaDPGCVLNFLQDVNTRQshlaqAGEKPGPICVHCSAGIGRTGTFIVIDMILdqivrngldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQ
|||||| ..  .|.||. .....     | .. ||..||||||.|||||.......|           .... ....||..|.| ||.. ||.|.||  .
pDhgvp.llellleflefidell.....alspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnpsqyrflyyfek

H
.
l
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 543-747 4.9e-37 122.2 In-house 85-294 (301) alignment 
Range on Protein: 543-747
Range on HMM: 85-294/301.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPA---------
| .||.|| .     .|..|||...||| .  ||| |.. |. |.|| .|||. | .||.||.  .. |.|.   |...|.. |  .|            
kkfiaaqgpm....kktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfk

-------RRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQagekpGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQR
       . .  ..   ||..||  .|  ||. ..||  ||          ||. ||||....|.|... ... |.|  ..|    .|.   .. || ..
vksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigg.....gpvvVHCSdtVsrsGvYcsvsiglEQckaegV...Vdvfqvtkavrrsk

SGLVQTEAQYKFVYYAVQHYIQ
 | |.|  || ..| ... |.|
pgaVtTLeqytsiydvidmylq
0049260 (Phosphotyrosine protein) phosphatases II 557-740 5.9e-37 122.1 In-house 19-144 (152) alignment 
Range on Protein: 557-740
Range on HMM: 19-144/152.0
VNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWpdegrseqfghariqcvsenstsdytlreflvswrdqparrifHYHFQVWPDHGVPADPGCVL
 ||. |||.|... . ..||| |...|.||.||..|.                                           .|..  ||||||| .. ..|
pntladfwrmlkelgittivmltellelgklkceqyi...........................................qylhlpwpDhgvpdlsqlll

NFLQDVNTRqshlaqAGEKPGPICVHCSAGIGRTGTFIVIDMILdqivrngldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
 .|. .. .      | .| ||. ||||||.|||||.......|           .... ....||..|.| |... |..|.|.
flllfiekl......aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_CG7180_pd Subfamily CG7180 544-747 6e-36 118.6 In-house 86-291 (296) alignment 
Range on Protein: 544-747
Range on HMM: 86-291/296.0
TYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKeKCARYWPDEGrSEQFGHARIQCVSENSTSDYTLREFLVSWR-----------DQPA
 || |..     . .|| .||..|..|..  .|. ||. .  | ..  ||| ..  ||.|.  .. |.|.. .. . |.| .  .           . . 
eyivteap....kketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaet

RRIFHYHFQVWPD-HGVPADPGCVLNFLQDVNTRQSHLaQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQT
| . ......|.  . ||     ...... |.. . .  .  .. ||..|..| | .|.| .. ||. |... .   . |.|. . ....| .| .||..
RivklfqlteWeledkvPlstnalielrrrvrlwrekv.dedpeegPvvvvssdGasRsGvylaidanlelvek...eeevdvFeavktlrrsRpqLven

EAQYKFVYYAVQHYIQ
  .||..|  ..... 
veeYkyiYdvlleavl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 544-748 8e-36 118.3 In-house 81-279 (287) alignment 
Range on Protein: 544-748
Range on HMM: 81-279/287.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSE-NSTSDYTLREFLVSWRDQPA-RRIFHYHFQ
..||.|| .      || ||| .|..... .... |.| | .. || .|||.  .  . |   .  ..  .   .|. | . .   .    | .  ... 
afiaaqgPi....aatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldll

VWPDHGVPADPGCVLNFLQDVNTrQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||....     .. |  ||.  .  ||. ... ||. ||...||||.|... . .....    |   ..|. ...  .| .| .|||.  |....| |
swPdkvlaPtavglirfvldvkq.hielardasevGPlvvhddvGiGrsGillatlvlvsrledlG...rvdvaavvirlreyraalvqavvqlrllyea

VQHYIQT
.  | .|
lvtyykt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 544-741 6.4e-35 115.2 In-house 95-278 (290) alignment 
Range on Protein: 544-741
Range on HMM: 95-278/290.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLV-SWRDQ-PARRIFHYHF
..| ||| |     .|| |.| || ||.. .|||  .  | || ||..|.|. ||.   ||.  . |  |..  . . .  |    .|.    .. |.. 
mfiltqGal....kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlki

QVWPDHGVPADPGCVLNFLQDVNTrqshlaqageKPGPICVHCSAGIGRTGTFIVIDMILdQIVRNGldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
. |||. |.     .|  |. . .           .||. |||||||||||||. |.. | ||. .|   |.|.  ... .|  | . || . ||  .  
kswpdksvalstlallrtlrilrk..........asGpvvvhcsaGiGrtGtfvaievgl.qilldG..keldlldlvralrnsrlnsvqvdiqylalve

A
.
i
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 543-746 1.4e-34 114.3 In-house 91-279 (439) alignment 
Range on Protein: 543-746
Range on HMM: 91-279/439.0
KTYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKekcarYWPDEGRSeQFGHARIQCVSENSTSDYTLREFLVS-WRDQ--PARRIFHYH
| ||||||     . .|. ||| .|....|  ||| |.  |  |     ||| ..    .|   ...  .    .|..| | |   ||.    | ....|
klyiatqgp....kkettddfwrlviekktvtivmltnlvesyk.....ywpsdaev.cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfh

FQVWPDHGVPADPGCVLNFLQDVNTrqshlAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVrngLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVY
.  |||. |||.   ||.||. .|.     |.  |. ||. ||||||.||||| | .|. |.|.    |. ..||.  ....| ||  .||. .|| |.|
yiawpdknvpaqashvldflrains.....andkeeygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiy

YAVQHYI
 ||   |
navledi
PTPc_DSPc_SM00012 637-743 1.6e-33 110.4 In-house 4-104 (105) alignment 
Range on Protein: 637-743
Range on HMM: 4-104/105.0
HYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQagekPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGldTEIDIQRTIQMVRSQRSGLVQTEAQYK
|||.  ||||||| ..  .|..|..|.. ... ..     .|..||||||.||||||...|..|.|. ..   .|.||.......|.||.|.||||.|| 
hyhytgwpdhgvPeesdsilellravkknknkses....skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqyl

FVYYAVQ
|.| |..
flyrall
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 544-743 3.5e-33 109.7 In-house 77-292 (297) alignment 
Range on Protein: 544-743
Range on HMM: 77-292/297.0
TYIATQGCLltQqvNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-EQFGHARIQCVSENSTSdY---TLREFLVSWRdQPARRIFHYH
 || .|| |  .  .|| |||..|.... ||||| .|  | |..||| |||.      . |.  .. .|. |   .    | |. . .| .  | . |  
kyilaqGpl..s..atvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyr.sesrvvrhvq

FQVWPDHGVPADPGCVLNF--------------LQDVN-------TRQSHLAQAGEKPGPICVHCSAGIGRTGTFIViDMILDQIVRNGLDTeiDIQRTI
|  |||||||.|   .  |              |  |.        .   |  .  .. .. ||||||.||.|  .   ... ...|..     |..  .
flswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvl.sdvilaklrkkrip..dvaail

QMVRSQRSGLVQTEAQYKFVYYAVQ
...|.||. ||||  |....| || 
silreqrarlvqtleqfellydavl
0044763 (Phosphotyrosine protein) phosphatases II 551-745 7e-32 105.9 In-house 30-170 (178) alignment 
Range on Protein: 551-745
Range on HMM: 30-170/178.0
CLLTQQVNtvTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRseqfghariqcvsenstsdytlreflvswrdqparriFHYHFQVWPDHGVPA
 .|... .   |......... ..||. |.|.|.|..|| .|||.|                                       ..|..  .|||||| 
lylgslpp..addlellkelgithivnlteelelgflkcdpywpeeag.....................................iqylhipipDhgvpd

DPGCVLNFLQDVNTRQshlaqaGEKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldtEIDIQRTIQMVRSQRSgLVQTEAQYKFVYYAVQHY
 .  .|.|.. ... .       ||.||. ||||||.||.||........ .         ....  |..||..|.  |... |....|.  ...
llehflefvefieeal......dekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaielvrerRp.ivpnpgqlrqLyefelrl
0049772 (Phosphotyrosine protein) phosphatases II 542-750 1e-31 106.2 In-house 83-284 (314) alignment 
Range on Protein: 542-750
Range on HMM: 83-284/314.0
FKTYIATQGCLLtqqvNTVTDF----------WNMV--WQENTRVIVM---------------------TTKEYERGKEKCARYWPDEGrseqfghariq
|...||||| |     .|| ||          |.||  .. |.|.|||                      ..  ..| | .|.....             
flkfIatqgple....itvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...........

cvsenstsdytlreF-------LvswrdqpARRIFHYHFQVWPDHGVPaDPGCVLNFLQDVNTRqshlaqagEKPGPICVHCSAGIGRTGTFIVIDMILD
                      .        |....|.   .||...| ..  .. ||. ...         .|.||. |||.||.||||||.|..... 
..............eelydpelf.......erlgikylripvpDgsap.lledfdeflefieea........dkggpvlvHCkaGkgRtgtfvvaaylmk

QIvrngldtEIDIQRTIQMVRSQRS-----GLVQTEAQYKFVYYAVQHYIQTLI
.         .... ....||..|.     |....  || |...|...|...|.
ll.......gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 543-747 1.1e-31 105.1 In-house 82-278 (307) alignment 
Range on Protein: 543-747
Range on HMM: 82-278/307.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSEN------STSDY--TLREFLVSWRdQPAR
| .|..|| |     ||. .|| |. ||.   ..|  |  | .| || .|||  ||.   ||.|      .|      .  .    . .. | |  | .|
kkficaqgpl....entqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksr

RIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaqagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRnGLDTeIDIQRTIQMVRSQRSGLVQTEA
 | |. .. |||.|||    . .|.|. |.  .           |. ||||||.||.|| . | .. |.... | .   |... .. .||||   .||||
tiqhlqwenwpdrgvpqinltainlleavrydtn..........pvvvhcsaGvGrsGtivaislvqdkmia.Ginc.kdmkklveelrsqrhyaiqtea

QYKFVYYAVQHYIQ
|| ...  . .|  
qylylhrvlleyfl
0051082 (Phosphotyrosine protein) phosphatases II 552-741 1.3e-31 104.6 In-house 16-148 (151) alignment 
Range on Protein: 552-741
Range on HMM: 16-148/151.0
LLTQQVntVTDFWNMVWQENTRVIVMTTKEYERGkeKCARYWPDEGrseqfghariqcvsenstsdytlreflvswrdqpaRRIFHYHFQVWPDHGVPAD
.....     ||........ ..||. ..|.|||  .|..|.|..|                                   ....|...  |||.|.|  
yrsggp..ladflellkelgiktivnlrseeerg..ycpeylpelg...................................ievlhipildwpdpglpls

PGCVLNFLQDVNTrqshlaqagEKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldteIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
.  ||.||. ..           |.||. ||||||.|||||.......| .         .... .....|..| |.||.. |. |...|
fdavleflellld.........kkngpvlvHCsaGkgRTGtlvalylmllg.........vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 544-747 1.3e-30 101.2 In-house 89-288 (305) alignment 
Range on Protein: 544-747
Range on HMM: 89-288/305.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSE-QFGH--ARIQ--C-------VSENSTSDYTLREFLVSWRDQP
 .| ||  |     .| .||| | .|..   | |  .  |.| .||. |.. . . . .|     .|.  .         ... .. |  ....    . 
rfictqapl....ektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgek

ARRIFHYHFQVWPDHGVPADPGCVLNFLQdvNTRQSHlaqagekpGPICVHCSAGIGRTGTFIVIDMILDQIVRnGLDTEiDIQRTIQMVRSQRSGLVQT
||.. |||.  ||| ||||   ..|..|.  ..| |.        ||| |||||||||||. .... ||||..  |   | | .. .| .| ||   .||
arkvthyhwidwpdrgvpaadlailelle..karpsk........gpivvhcsagigrtgsvvmleyildqlla.gqiie.dtdkilqkireqrnnsiqt

EAQYKFVYYAVQHYIQ
.||| ||.  .  |..
daqylfvhqvilnyfr
SH2 SH2 domain 211-286 1.1e-28 89.7 Pfam-A 1-77 (77) alignment 
Range on Protein: 211-286
Range on HMM: 1-77/77.0
WFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFVLSVRTDDKVTHVMIRWQDKK-YDVGGGESFGTLSELIDHY
|.||..|..|||.|.||..|.|.||||||.|||||..|||..|.||.|. |. .... | . ..|.| .|.||..||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 543-744 3.1e-28 93.3 In-house 88-234 (392) alignment 
Range on Protein: 543-744
Range on HMM: 88-234/392.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGkekcarywpdegrseqfghariqcvsenstsdytlreflvswRDQPARRIFHYHFQV
|.|||.||      . .. |||.||.|||.  |.| ||  |                                            . . || .  .||  
kayiasqgpn....aaslddfwrmvfqenvttiamvtklkegd..........................................kgddartvaqfhfte

WPDHGVPADPGCVLNFLQDVNtrqshlAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
|||..||    ..|.|...|.      |. |.   |. .|||||.||||  | || .. .  .      .|.   .  .| .|  .|||. || |.| ||
wPdkdvpkhtssllkfikevk......adfGqythpliihcsagvgrtgvvisidsvvahakkt...rmvdvfnfvtnirrkrpymvqtkeqyafiygav

QH
  
le
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 543-746 1.1e-27 91.5 In-house 96-289 (305) alignment 
Range on Protein: 543-746
Range on HMM: 96-289/305.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEgRSEQFgHARIQCVSENST--------SDYTLREFLVSWRDQPARR
| .|..|| |     .|. .|| || |..   |||  |  | || |||.|||   . |.  . .  .| || .        ..  .  . ...  .    
krficaqgpl....dqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa.qgekl.elksgivvenvsgskpmerdaeiqitllnltysgdqkms

IFHYHFQVWPDHGVPAdpgCVLNFLQDVNtrqshlAQAGEKpGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTeiDIQRTIQMVRSQRSGLVQTEAQ
. | ..  ||| |||    | |  |. .       |  | |  || |||||||||||| . |. ||..|  |       .   .. .| ||.  .|.. |
vrhlqwtewpdrgvpp...ckltslells......airgsk.vpivvhcsagigrtgtivaieyilekiaenkpcp..pmpelvkalrdqrafsiqndvq

YKFVYYAVQHYI
| |..  .  |.
ylfihrvmlnyf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 543-746 6.2e-27 89.3 In-house 75-270 (285) alignment 
Range on Protein: 543-746
Range on HMM: 75-270/285.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDE-GRSEQFGHARIQCV--SENSTSDYTLREF-LVSWRDQPARRIFHY
 |||.||| |     .|..||| |..||.   ..|    .| | |||| |.|.. |   .||.  |      |.. .   |  . ..   |  .  ..  
styittqgpl....petlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymn

HFQV--WPDHGVPADPGCVLNFLQDVNtrqshlaQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQrsgLVQTEAQYK
| ||  |||.  | |   .... . |.       .   |  |||||||||.||| ||. ||    .|. |     .|| | .. .| |    ||.  |. 
hvqvpwwpdqlapedarpmielykwvk.......kvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfq...avqshmqfl

FVYYAVQHYI
|.|  .  |.
flyvvlmeyf
subfamily_PTPN6_pd Subfamily PTPN6 316-394 1.7e-26 88.0 In-house 17-94 (306) alignment 
Range on Protein: 316-394
Range on HMM: 17-94/306.0
NARVEQLVKGGFWEEFESLQQ-DSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLdvEHSVAGAEYINANYIRLPTD
.   |.| | ||.||||.||| ......||.|| |.||. ||||.||||.|||||.|   |.||.|..|||||||.  . 
ekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevk
subfamily_ptpA1_pd Subfamily ptpA1 543-700 1.7e-26 87.9 In-house 89-253 (418) alignment 
Range on Protein: 543-700
Range on HMM: 89-253/418.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFG----------HARIQC--VSENSTSDYTLREFLVSWRdQ
| .|.||| |     ||..||| |||..  |.||| ..| |  . || ||||..   |||              ..   | ..   .   |.  ...   
kqfictqgpl....pntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfe.g

PARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMIL
 .| | .|... |||| .|     . ..|. .  || ..  . ..  || ||||||.||||||    ...
etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
0048076 (Phosphotyrosine protein) phosphatases II 625-745 3.5e-26 87.0 In-house 37-142 (145) alignment 
Range on Protein: 625-745
Range on HMM: 37-142/145.0
VSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqagekPGPICVHCSAGIGRTGTFIVIDMILDqivrngldTEIDIQRTIQMVRSQ
 | .. . | ...|..  ||||||| ..  .|.||. ... ...       .||. ||||||.|||||.......|           .... ....||||
tselellerlgiqylylpwpDhgvpdllellleflefieealke.......ggpvlVHCsaGvgRtgtlvaaylmll........lgvsleealelvrsq

RSGLVQTEAQYKFVYYAVQHY
|.| |... |..|.|......
rpgavpnpgqlrflyefelel
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 543-742 8.6e-26 85.2 In-house 81-265 (281) alignment 
Range on Protein: 543-742
Range on HMM: 81-265/281.0
KTYIATQGClltqQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-EQFGhaRIQCVSENSTSDYTLREF--LVSWrDQPARRIFHYH
. || |||     . .| .||| |.|||||  |||  .  |  .|||| |.| . .   ||   ..    |.|| . .|      .|. .  .| | |. 
rgyiltqgp....kketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfd..klsvsyedstvnkslvttrlnlsy.egetrlithwl

FQVWPDHGVPADPGCVLNFLQDVNTRQShlaqagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRNglDTEIDIQRTIQMVR-SQRSGLVQTEAQYKFV
.. |||  ||     .|. |. . .| .          |  .|||||.||.||.. ... |. |      |  ||.. .  .| . |.  |||  || ..
wkewpdwqvpessevmlkilrkirarst..........ppvihcsagvgrsgtlmaveialqsihsh..ftlpdikqivshlrvtgraasvqtlqqymli

YYAV
.  .
wkvl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 543-752 3.3e-25 83.6 In-house 72-265 (267) alignment 
Range on Protein: 543-752
Range on HMM: 72-265/267.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEyerGKEKCARYWPDE-GRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFHYHFQ
...|.||. |     ||.|||.... ...  |||. ||    ....  ..|| . |.....    ..   |.   || .  . . .... |. .  |...
nafivtqdpl....kntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyyk

VWPdhgVPADPGCVLNFLQDVNTRQsHLaQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRNGldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |    . ..    |. |  . ... .| . |..  |. |.||.|.||.|||.|||  |... ..|     ||   .. .|||| |||.|  .| ...  
kwn...intnnkpylkplfgilakn.ql.engnr..PlvvacsdGvGrsGtflvidsqlerakteg...vsdifdflrkirsqriglvdtkeryiyihel

VQHYIQTLIAR
. .| .  . .
laeyaegrlke
0048179 (Phosphotyrosine protein) phosphatases II 621-740 3.7e-25 83.7 In-house 47-139 (144) alignment 
Range on Protein: 621-740
Range on HMM: 47-139/144.0
REflvswrdqparrIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaqageKPGPICVHCSAGIGRTGTFIVIDMILdqivrnglDTEIDIQRTIQM
||            ...|..  ||||||| ..  .|.||. ... ..       ..||. ||||||.|||||........           .... ....
re............giqylhlpwpDhgvpdllellleflefieeale.......eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealal

VRSQRSGLVQTEAQYKFVYY
|||.|.| |... |..|...
vrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 543-743 1.4e-24 81.2 In-house 94-287 (310) alignment 
Range on Protein: 543-743
Range on HMM: 94-287/310.0
KTYIATQGCLltQqvNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTsDYTLREFL-------VSWRDQPAR--
.|.| .|| |  |   |. ||| |..|| .  |..  |  | |. ||  |||  | .| .|  |.  .|| |  .. . ..        |   .|||   
stficsqgpl..q..htiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesse.efeicnlavtfvpdnvpvdeqpanlk

--RIFHYHFQVWPDHGVPADpGCvlnflQDVntRQSHLAQAgeKPGPICVHCSAGIGRTGTFIVIDMILDQIvRNGLdtEIDIQRTIQMVRSQRSGLVQT
  |.   ..  ||| ||| .  |     . |   |  |||   . ||  ||||||..|... . ... .|.. ..||  ..|..  .  .. .|   .||
elrvslikwpnwpdrgvpde.kc.....htv..pqrllaqv..rhgpcvvhcsagkdrlyvvvalklkidkl.drgl..kvdaeevktellksraiciqt

EAQYKFVYYAVQ
| || .. .   
elqyliidrvri
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 555-759 1.6e-24 81.5 In-house 75-272 (290) alignment 
Range on Protein: 555-759
Range on HMM: 75-272/290.0
QQVNTVTDFWNMVWQENTRVIVMTTKEYERGKE----KCARYWPDE-GRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFHYHFQVWPDHGVP
..  |. .|| |. ||. . .||. .  |. ..     ||.| |.. | . .|.   ..| |     |   || .| . |.    . |. .. | .  |.
krnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvq

ADPGCVLNFLQDVNTRQShlaqagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRngLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTL
 |.  .|. .| |.....          |. |||  || |  ..  |..    |.   .  .. ..  ....|.||  ..... .. || ...  ...  
edtktllsliqkvkaskt..........pvivHcvdGiSrsAalaaiilgyQkiae..tsgsvkledvlkalrkqralaitsalelafvdagivllaiev

IARKRAEEQS
  .   ||. 
ldqfaeeete
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 552-753 2.7e-24 80.6 In-house 39-225 (255) alignment 
Range on Protein: 552-753
Range on HMM: 39-225/255.0
LltqqvnTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFgHARIQCVSENSTSDYTLREFLVS--WR-DQPARRIFHYHFQVWPDHGV
|      ||  |.... | .| |.|| .  .| |.||| .|.| |    .   | .. .. .|..|  ||   .       . .. . ||... |...  
l......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklk.ladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PADPGCVLNFLQDVntRQSHlaqagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRNG---LDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHY
| ..  .|| |. |  |.|.         .. ||||.||||. .|......  ...|.      .|.|  . .. .||.|.. ..|  |  |  . |  .
Pelareilnilkvv..rdsk.........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl

IqtlIARK
.     ..
v...fpkg
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 558-747 7.2e-24 79.3 In-house 93-272 (288) alignment 
Range on Protein: 558-747
Range on HMM: 93-272/288.0
NTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARR--IFHYHFQVWPDHGVPADPGC
 |.  .|.|. ... . ||| ..  |.|||| | |.|   |.. ..|.   .   ...  | ...  |.    .   .  . . |.. |.|.||| .   
gtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenyls

VLNFLQDVntrqshlaQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVrngLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQ
 |..|. .        .. .|  || ||.|||.|||||.|.| ..|...    ||  . |.. ..  | .|   .||| || .|.  | ... 
plrllevl........kslqk..PivvhssaGvGrtgtlililialeslr...lddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 544-738 1.1e-23 78.5 In-house 91-273 (301) alignment 
Range on Protein: 544-738
Range on HMM: 91-273/301.0
TYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-EQFGHARIQCVSENSTS--DYTLREFLV--SWRDQPARRIFHY
 .||||| |     ||  ||| |. | .   ||| ... |. .|||. | | . ..  . |  .|. .....    . . |.. |  | .. ..| . ||
rfiatqgPl....kntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthy

HFQVWPDHGVPADPGCVLNFLQdvntrqshLAQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
 .. |.|.|||     . ....        |..  ||  || |||||||||. .||  ...  ..     | .|....... .| .|   |||. |  ..
qysewtdrgvPkshaelfdlme........lvkksek..PivvhcsaGiGrsvafigteylarevea...dptieltealkhlrehrwngvqtnsqlywm
subfamily_egg_pd Subfamily egg 540-753 1.1e-22 75.1 In-house 80-277 (307) alignment 
Range on Protein: 540-753
Range on HMM: 80-277/307.0
EMFKTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERgkEKCARYWPD-EGRSEQF--GHARIQCVSENSTSDY--TLREFLVSWRDqpARR
 .. ..| .|  |     ||| ||| ||.||. . ||| |   |   |.|  |||  |  | ..  |  ||...  .|..|   .. .. .   |     
pllnefilaqapl....kntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..dee

IFHYHFQVwpDhgvpadpgcvLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgLDTEIDIQRTIQMVRSQRSGLVQTEAQ
 |  |.|   |          .|.. || .    | .. .   |. |..  |. ...|.. |.. | ...|    |   ..|.....| .|   |..  .
rflehwqg..d..........vnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvll

YKFVYYAVQHYIQTLIARK
| |||  |  ... .|.  
ylfvyrlvlfffrdvigsa
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 615-745 3.4e-22 73.4 In-house 74-193 (440) alignment 
Range on Protein: 615-745
Range on HMM: 74-193/440.0
TSDYTLREFLVSWRdqpARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQShlaQAGEkpGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDI
 |||    .. .     .| . .||.| |||.|||   | ||...||||  |    .||.  ||. |||||| ||||  |..| || .  |.    .|||
dsdyinasyingie...srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqe...kagn..gpllvhcsagagrtgviiavdsilreakrs...dqidi

QRTIQMVRSQRSGLVQTEAQYKFVYYAVQHY
   |. .|..|  .|||  || ||. || . 
fsfinsmrnnrpqmvqtpeqyafvheavleg
subfamily_hpo-7_pd Subfamily hpo-7 556-761 5.3e-21 69.7 In-house 43-242 (263) alignment 
Range on Protein: 556-761
Range on HMM: 43-242/263.0
QVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQfGHARIQCVSENSTSDYTLRE--FLVSWR-DQPARRIFHYHFQVWPDHGVPADP
 |.|.  |.... | .| |.|| .  .| |.||| .|.| |    |   | .. .. .. ||  |.   .|      .  . . || .. |...  | ..
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekq.klanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

GCVLNFLQdVNTrQSHlaqagekpgPICVHCSAGIGRTGTFIVIDMILDQIVRNGL---DTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTL
  .|| |. |.. .|.         .. ||||.||||.  | |....  ...|.      .|.|  . .. .||.|.. ..|  |  |  . |  ..   
reilnilk.var.nsk.........slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnn

IARKRAEEQSLQ
 |.  .| .  .
fakgeleakyqe
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 543-739 1e-19 65.5 In-house 5-197 (199) alignment 
Range on Protein: 543-739
Range on HMM: 5-197/199.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLVSWRD---QPARRIFHY
. |||||  |     .|..|||.|||.  .  |||   .    .   . |||  |  . ..|   . . .  . .|||.  ....        .| | ||
rryiatqhpl....retmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

HFQVWPDHGVPADpGCVLNFLqdVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQiVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
 |  | ..  |      . |.  | .|.       ||  |. |||| | | || |. .|. .     .   . .|.    . .|  | |.. .  .|.|.
qftswkekttpnv.alfvgfv..vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfi

Y
|
y
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 543-739 1e-19 65.5 In-house 4-196 (198) alignment 
Range on Protein: 543-739
Range on HMM: 4-196/198.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPD-EGRSEQFGHARIQCVSENSTSDYTLREFLVSWRD---QPARRIFHY
. |||||  |     .|..|||.|||.  .  |||   .    .   . |||  |  . ..|   . . .  . .|||.  ....        .| | ||
rryiatqhpl....retladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

HFQVWPDHGVPADpGCVLNFLqdVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQiVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV
 |  | ..  |      . |.  | .|.       ||  |. |||| | | || |. .|. .     .   . .|.    . .|  | |.. .  .|.|.
qftswkekttpnv.alfvgfv..vasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrs.heesktsvvdlfevakrlrqarcgiisslqhynfi

Y
|
y
subfamily_CG42327_pd Subfamily CG42327 543-672 1.5e-19 64.8 In-house 72-202 (319) alignment 
Range on Protein: 543-672
Range on HMM: 72-202/319.0
KTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGR---SEQFGHARIQCVSENSTSDYTLREFLVSWRD-QPARRIFHY
  |||.|  |     .. .||| .||. ..||||  |. .| | ..||.|.| .      . .|. ..     ..   | .  .|.   | . .| . ||
nsyiaaqvsl....edsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthy

HFqVWPDHGVPADPGCVLNFLQDVNTR--QSHLAQA
 .  |.. .|||..  ..  | .|..      | ||
wy.kwleaevPaeeaaliamllevrsslksysleqa
subfamily_eak_pd Subfamily eak 543-761 7.5e-19 62.3 In-house 93-320 (332) alignment 
Range on Protein: 543-761
Range on HMM: 93-320/332.0
KTYIATqGcllTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSE-QFGHARIQCVSENSTSDYTLREFLVSWRDQpARRIFHYHFQ
. || | |     . . |  ||.|| ....  ||.  .. | . ||  .|.||..| | .||.  ... .    . .  | . .|  .. . |..||.. 
rkyilt.G...iasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrllelskGne.thrvlhykvf

VWPDHGVPA--DPGCVLNFLQDV----------NTRQSHLAQAGEKPG---PIcVHCSAGIGRTGTFIVIDMILdQIVRNGLDTEIDIQRTIQMVRSQRS
 | .  .|   |   . . ...|          .  .| | .    |    || . .. |  |.|.|.|||... ... |       ..  |  |.|.| 
GwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapi.iqsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskri

GLVQTEAQYKFVYYAVQHYIQTLIARKRAEEQSLQ
  | .. |. |.| .| .|...   | |  .. |.
hsvlvalqhsfiyeivldyllrrnnrlrdlkkyle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 635-746 9.5e-19 62.3 In-house 217-344 (350) alignment 
Range on Protein: 635-746
Range on HMM: 217-344/350.0
IFHYHFQVWPDHGVPADPGCVLNFLQ----DVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILD--QIVR------NGLD----TEIDIQRTI
... ... |.| ..  .|  .|. |.     ...  ...    ..  || ||||||.|||||.. .|..|   .|..      . ||    |.  |. ..
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

QMVRSQRSGLVQTEAQYKFVYYAVQHYI
. .|.||  .||.  |. |.| |...| 
nelrkqrismvqnldqfifiYeallfyf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 551-771 2.3e-18 61.0 In-house 86-301 (312) alignment 
Range on Protein: 551-771
Range on HMM: 86-301/312.0
CLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQ---C----VSENSTSDYTLREFLVSWR--DQpARRIFHYHFQ
|  .   ||.| ||...    .  |.. .   | | ||||.|  |     ..   |.    |    .  .|    | | . |  .   |   .. || . 
ctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgq.esklnhyqwa

VWPDHGVPADPGCVLNFLQDVNTrqshlaqaGEKpgPICVHCSAGIGRTGTFIVIDMILDQIvRNGldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYA
 |||||.|      | .|  |.           |  |.  |||||.|||||...|. ..  . |       ... .  ..| .|.  |.. .|| ..  .
swpdhgmpdscdtalrllsavkk........dkk..pviahcsagvgrtgtlaliesmiaal.rhp..rkqnvkdsfvllrkdrarsvrvfpqyvyalrc

VQHYIQTLIARKRAEEQSLQVGREYTNIKY
| ... .    || |..  ..   |..|| 
vleflyskglykrneqewtkfketyakika
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 558-742 1.3e-17 58.2 In-house 102-284 (302) alignment 
Range on Protein: 558-742
Range on HMM: 102-284/302.0
NTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRS-EQFGHARIQCVSENS-TSD---------YTLREFLVSWRDQPARRIFHYHFQVWPDH
.|.  .| .. | |. ..|  ..  | ...||| |. |. .   .||.  .. || .   ..         ||.      ....  . .   .|  ||||
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

GVPADPGCVLNFLQDVNTRQSHlaqagekpgpICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
| |...   |. |.  .. .            . ||||||.|||||.. |   ..  ...      |.   .. ||. | | ||.| |  ..   |
Gapkeaytaldilkfcesykkn..........vlvhcsaGvGrtGtlvaikyGiqlcskkkv...tdllsivlpvrqcryGavqdeqqliylllcv
0045450 (Phosphotyrosine protein) phosphatases II 324-392 2.9e-17 58.8 In-house 26-95 (307) alignment 
Range on Protein: 324-392
Range on HMM: 26-95/307.0
KGGFWEEFESLQQDSRD-TFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLP
. |...|||.|..   .  .........||. ||||..||||||||||| ....|. .  ||||.|.|.|
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvp
0046845 (Phosphotyrosine protein) phosphatases II 326-392 3.2e-17 58.3 In-house 1-68 (284) alignment 
Range on Protein: 326-392
Range on HMM: 1-68/284.0
GFWEEFESLQQDSRDTF-SRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLP
|..|||| |..   . . |.. ....||. ||||..||||||.||||  ..... . .||||.|.. .
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgy
0050432 (Phosphotyrosine protein) phosphatases II 318-392 5.9e-17 57.4 In-house 27-102 (308) alignment 
Range on Protein: 318-392
Range on HMM: 27-102/308.0
RVE--------QLVKGGFWEEFESLQQDSRdTFSRNEGYKQENRLKNRYRNILPYDHTRVKLldvehSvAGAEYINANYIRLP
.|.        .| .|...|||| |..     .... ....||. ||||..||||||.||||     .  |  ||||.|....
svldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....d.egsdYInAsyvdgy
subfamily_PTPRD_pd Subfamily PTPRD 324-389 7.4e-17 56.2 In-house 22-84 (564) alignment 
Range on Protein: 324-389
Range on HMM: 22-84/564.0
KGGFWEEFESLQQDsrDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYI
.  | ||......   ..|. ..  |..|. |||| ||..|||.||.|  ||    | .||||..|
dlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfi
0051299 (Phosphotyrosine protein) phosphatases II 324-395 1.6e-16 56.1 In-house 22-91 (288) alignment 
Range on Protein: 324-395
Range on HMM: 22-91/288.0
KGGFWEEFESLQQDSRDtFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIRLPTDG
. |..|||| |..   | .... ....||. ||||..||||||.|||| ...  | |  ||||.||...  .
ltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidgynlk
DSPc_SM00195 327-393 3.1e-16 54.9 In-house 2-66 (263) alignment 
Range on Protein: 327-393
Range on HMM: 2-66/263.0
FWEEFESLQQDSRDTfSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIRLPT
..||||.|..   .. . .|. |..|. ||||.|||||||||||| . |..  | .|||||||....
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgan
PTPc_SM00194 327-393 3.1e-16 54.9 In-house 2-66 (263) alignment 
Range on Protein: 327-393
Range on HMM: 2-66/263.0
FWEEFESLQQDSRDTfSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIRLPT
..||||.|..   .. . .|. |..|. ||||.|||||||||||| . |..  | .|||||||....
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikgan
subfamily_CG42327_pd Subfamily CG42327 662-748 4.6e-16 53.4 In-house 233-317 (319) alignment 
Range on Protein: 662-748
Range on HMM: 233-317/319.0
VNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNglDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQT
.|   |  .   |. ||. |||| |.||||. |  |. . ..  .     .|| .... || .|.  |.|  ||.|.|  .. | . 
ingnissrsgtresqGPlvvhcsdGvGrtGlviasdiairslees..krsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 317-389 9.3e-16 52.8 In-house 9-82 (318) alignment 
Range on Protein: 317-389
Range on HMM: 9-82/318.0
ARVEQLVKGG---FWEEFESLQQDSRdTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYI
 .|..| . |   . ||.| |..... |... .  .. |. |||| |||.|||||||| ..| .. |..|||||||
shvrrlresGelllseeyerlsrsee.tvtslkslepvnkaknryanilaydhtrvkLqmle.geegsDyinanyi
0040438 (Phosphotyrosine protein) phosphatases II 320-393 1.2e-15 53.0 In-house 13-83 (317) alignment 
Range on Protein: 320-393
Range on HMM: 13-83/317.0
EQLVKGGFWEEFESLQQDSRDtfSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIRLPT
 .. .....|||| |.. . |  ........||. ||||..||||||.|||| ...  . .  ||||.|.  | 
lksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpn
0047943 (Phosphotyrosine protein) phosphatases II 321-393 1.2e-15 53.2 In-house 8-74 (273) alignment 
Range on Protein: 321-393
Range on HMM: 8-74/273.0
QLVKGGFWEEFESLQQDSRdTFSRNEGYKQENRLKNRYRNILPYDHTRVKLldvehSVAGAEYINANYIRLPT
.| .....|||| |..     .... ....||. ||||..||||||.||||     .  |  ||||.|.... 
llgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgyn
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 555-758 2.2e-15 50.9 In-house 101-297 (302) alignment 
Range on Protein: 555-758
Range on HMM: 101-297/302.0
QQVNTVTDFWNMVWQENTRVIVMTTKEYERGKeKCARYWP-DEGRSEQFGHARIQCVSENSTSDYTlREFLVS-WRDQPARRIFH--YHFQVWPDHGVPA
.... | .|| ||.||.   .|.  .| |  |     ..|   |  ...|. ..     ..... .  .. .    .  .  ..   |... |... || 
dsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpv

DPGCVLNFLQDVntrqshLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRNgldTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTLI
  . . .  ..|       |.  .   .. .    |.|| |.|..  . .... ..    |  |. ... .||||.  |..  || ..| |.  ||.. .
kyaeliktaakv......fakkikadentvivSknGaGRagafltlavaveklqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkkv

ARKRAEEQ
 .   ...
tkpeekkk
subfamily_PTPN12_pd Subfamily PTPN12 327-396 5.2e-15 50.1 In-house 10-83 (290) alignment 
Range on Protein: 327-396
Range on HMM: 10-83/290.0
FWEEFESLQQDS-----RDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDvEHSVAGAEYINANYIRLPTDGD
| .||..|.. |      ...|...| |.||. ||||..|||||..||.|   .... | .|||||.|. ...  
fakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelsk.ieeeegsdYinanfikgvegkl
0036941 (Phosphotyrosine protein) phosphatases II 319-393 5.4e-15 50.9 In-house 7-75 (297) alignment 
Range on Protein: 319-393
Range on HMM: 7-75/297.0
VEQLVKGGFWEEFESLqQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLldvehSVAGAEYINANYIRLPT
 ..| . ....|||.| ..    .|.. . ..||. ||||..|||||||||||     .  |  ||||.|. .. 
ekllflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgyd
subfamily_PTPN13_pd Subfamily PTPN13 321-400 1.2e-14 49.2 In-house 7-79 (273) alignment 
Range on Protein: 321-400
Range on HMM: 7-79/273.0
QLVKGGFWEEFESLQQdSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsvagaeYINANYIRLPTDGDLYNM
.| ..   |||. |..  . . . ..| |.||. ||||||.||||.||||| |         ||||..|..| . | |..
kldqqqPaeefkelre.lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyey
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 317-390 1.3e-14 49.0 In-house 13-84 (288) alignment 
Range on Protein: 317-390
Range on HMM: 13-84/288.0
ARVEQLVKGGFWEEFESLQQDSRdTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYIR
|. ..  . || ||..|| .  . | | . | . .|  |||||||||||..|||| ..|  .|||.||||.|| 
akksarnrtgfseeynsLaalek.tksvtagrlavnakknRyrnilpyDekrvklkkle.eeagaDYinasyid
subfamily_PTPRB_pd Subfamily PTPRB 325-390 1.3e-14 48.9 In-house 25-88 (293) alignment 
Range on Protein: 325-390
Range on HMM: 25-88/293.0
GGFWEEFESLQQDSRDTfSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIR
 .| ||.|.|..  .|. . .   ...|| ||||.|||||||.|||| ....  .|..|||||||.
lrfseeyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkd.esgsDYinanyip
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 325-389 1.5e-14 48.8 In-house 23-84 (319) alignment 
Range on Protein: 325-389
Range on HMM: 23-84/319.0
GGFWEEFESLQQDSRDTFSrnEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYI
 .. .||. |.. . |||.  .  |.||. ||||.|||.||.|||.| ...  | |..||||..|
tllekefkllkeavndtfd..saskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfi
0043336 (Phosphotyrosine protein) phosphatases II 322-393 2.3e-14 49.0 In-house 17-85 (278) alignment 
Range on Protein: 322-393
Range on HMM: 17-85/278.0
LVKGGFWEEFESLQQDSRdtFSRNEGYKQENRLKNRYRNILPYDHTRVKLlDVEHSVAGAEYINANYIRLPT
 .| ....|||.|..     .... ....||. ||||..||||||.|||| ... .. .  ||||.|. .. 
nlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvkl.sllggdldsdYinAsyvdgyn
subfamily_Ptp69D_pd Subfamily Ptp69D 325-390 6.3e-14 46.8 In-house 22-85 (307) alignment 
Range on Protein: 325-390
Range on HMM: 22-85/307.0
GGFWEEFESLQQDsRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIR
 |. .|.|.|..      | . . |.|| ||||| .| ..|.|||||  ..   . ..||||..|.
fglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkking.kedsdYinasfik
subfamily_PTPRG_pd Subfamily PTPRG 324-389 1.8e-13 44.6 In-house 18-84 (563) alignment 
Range on Protein: 324-389
Range on HMM: 18-84/563.0
KGGFWEEFESLQQDSRDT-FSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYI
. || ||||.||. . .. .  .   |.||. |||| ||..||..|||| ..       .|||||||
digfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyi
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 324-390 3.9e-13 44.1 In-house 14-78 (281) alignment 
Range on Protein: 324-390
Range on HMM: 14-78/281.0
KGGFWEEFESLQQDSRDTFSRnEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVaGAEYINANYIR
. || ||.|.|..  .|  ..   ...||.|||||.||  ||.||||. . |..   ..|||||.. 
naGfieeyeklaaigvdntat.askadenvlknrYsnivaYDatrvkvtpneenk.ntDYinanfvp
0038934 (Phosphotyrosine protein) phosphatases II 636-748 9.8e-13 43.7 In-house 80-179 (194) alignment 
Range on Protein: 636-748
Range on HMM: 80-179/194.0
FHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHlaqagEKPGPICVHCSAGIGRTGTFIVIDMILdqivRNGLdteiDIQRTIQMVRSQRSGLVQTEAQY
..|.   .||.|.. .   .|.||. |..  .       ..| . ||| ||.|||||...  .|     |.|.    . .  |...|. | | ...  ..
ieylklpfpddgtvPsleillrfldlvdeflne.....dpggvvaVHCkaGlgRtGtlvaaYLiy....rlgm....saeeAialfrekRpgaipnqdyl

KFVYYAVQHYIQT
. ..  ...... 
eallkrykelrka
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 533-615 2.9e-12 41.0 In-house 96-170 (350) alignment 
Range on Protein: 533-615
Range on HMM: 96-170/350.0
REREREREMfkTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQfgHARIQCVSENST
   | . .    |||||. |     .|| ||.... . . .||.. |.. | . ||| |||.. . ...  . ...   || .
fsveinpdf..kYiatqaPl....pstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsyddi..tvklaskwenim
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 319-390 9.6e-12 39.7 In-house 21-93 (298) alignment 
Range on Protein: 319-390
Range on HMM: 21-93/298.0
VEQLVKGGFWEEFESLQQDSR--DTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYIR
 ..    |. .||. |.. |   .... . . |.||. |||| .|...|..|| | ... .   ..|||| .. 
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked.adeesdYiNAsflh
subfamily_PTPN3_pd Subfamily PTPN3 320-395 1.1e-11 39.2 In-house 10-79 (280) alignment 
Range on Protein: 320-395
Range on HMM: 10-79/280.0
EQLVKGGFWEEFESLQQDSRDtFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEhsvAgaEYINANYIRLPTDG
|.| .|    .|| | .  ..  . ..  | ||  |||||.|||||.||||| . |   .  .||||||. .  ..
eglesGavlaqfeqlyrkkpg.laisaarkpenlsknryrdilpydatrvklkese...t..dyinanyvnmeips
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 351-395 1.6e-11 38.5 In-house 46-97 (350) alignment 
Range on Protein: 351-395
Range on HMM: 46-97/350.0
ENRLKNRYRNILPYDHTRVKLL-------DVEHSVAGAEYINANYIRLPTDG
|   ||||.|||||.|.||||         ..||. . .||||||..|.  .
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfs
0045098 (Phosphotyrosine protein) phosphatases II 345-392 2.2e-11 39.1 In-house 26-62 (278) alignment 
Range on Protein: 345-392
Range on HMM: 26-62/278.0
NEGYKQENRLKNRYRNILPYDHTRVKlldvehsvagaEYINANYIRLP
... . .|. ||||..||||||.|||           .||||.||. .
tpalylgnldknRykdilpydhsrVk...........dYINAsyidgy
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 326-400 2.8e-11 37.7 In-house 11-84 (287) alignment 
Range on Protein: 326-400
Range on HMM: 11-84/287.0
GFWEEFESLQQDSRD-TFSRNEGYKQENRLKNRYRNILPYDHTRVKLldVEHSVAGAEYINANYIRLPTDGDLYNM
   .|.. |..||.  |.   .  .  .  |||| ..||.|.||| |  ....  |..||||||.   || . .  
dvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvll..saegelGsdyinanyvasytddeafia
subfamily_PTPRK_pd Subfamily PTPRK 324-394 4.6e-11 37.1 In-house 18-80 (314) alignment 
Range on Protein: 324-394
Range on HMM: 18-80/314.0
K---GGFWEEFESLQQDsrdtfsRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIrlptD
.    || ||.||| .        .   |.||| |||. .||.||..||.|  ..   . ..||||..|    |
raegygfkeeyeslfeg......wdaakkdenreknrsgdilaydrsrvflitidgd.pssdyinaali....d
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 638-746 5.9e-11 36.3 In-house 223-344 (349) alignment 
Range on Protein: 638-746
Range on HMM: 223-344/349.0
YHFQVWPDHGVPADPGCVLNFLQD----VNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILD--QIVRN---GLDT----EIDIQRTIQMVRSQ
  .. |.| ..  .|  .|. |.     ...  ..|    ..  .. |||||| ||||... .|..|.  . ..|    ..     .  |. ..  .| |
lqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkq

RSGLVQTEAQYKFVYYAVQHYI
|  .||  ||. ..| |. .|.
rismvqnlaqfiaiyealLkyf
subfamily_PTPRA_pd Subfamily PTPRA 316-390 8.8e-11 36.2 In-house 24-95 (330) alignment 
Range on Protein: 316-390
Range on HMM: 24-95/330.0
NARVEQLVKgGFWEEFESLQQ-DSRDTFSRneGYKQENRLKNRYRNILPYDHTRVKLLDVeHSVAGAEYINANYIR
. |. .  |  | |||..|   . . |.      |.||. |||. ||||||..|| |  . . |  ..|||| .| 
rirsaddnk.lfreefnalPagpiqatlel..askeenkeknrvvnilPydfsrvilsvk.eGveesdyinasfid
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 313-390 1.1e-10 35.5 In-house 7-82 (392) alignment 
Range on Protein: 313-390
Range on HMM: 7-82/392.0
AGINARVEQLV-KGGFWEEFESLQQdsRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLlDVEHSVAGAEYINANYIR
| . | ||.      | |||  | .   | . .. . |. |  ||||.|||||| .|||| .|   ..  .|.|| ||.
aqfpafveknrhsalffeefhdlpg..pdiypqtvaqkeinlkknryknilpydsarvkl.eviddipdsdylnasyip
0040439 (Phosphotyrosine protein) phosphatases II 344-393 1.1e-10 37.1 In-house 3-51 (249) alignment 
Range on Protein: 344-393
Range on HMM: 3-51/249.0
RNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIRLPT
.......||. ||||..||||||.|||| ...  . .  ||||.|| .. 
ysvallpenkdknrypdilpydhsrvklsilpg.lflsdyinAsyidgyy
subfamily_PTPN1_pd Subfamily PTPN1 328-394 1.4e-10 35.3 In-house 8-69 (290) alignment 
Range on Protein: 328-394
Range on HMM: 8-69/290.0
WEE-FESLQQDSRdTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsvagaEYINANYIRLPTD
..| .. ......  |. .|  ..||| .||||.. ||||.|.|| . .      .||||. . |.  
ykeiyldirkeas.dfptreaklpenrnlnryrdvspydhsrikleradn.....dyinaslveleea
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 554-746 1.6e-10 35.1 In-house 88-279 (303) alignment 
Range on Protein: 554-746
Range on HMM: 88-279/303.0
TQQ--VNTVTDFWNMVWQENTRVI--VMTTKEYERgkEKCARYWPDEGRSEQFGHARIQcVSEN----STSDYTLREFLVSWRDQPArRIFHYHFQVWPD
||     | .|||.|. ... ...  ..|  ||..        .| .    .| .  |. | |      .  ..|.   ||  |  .  .  .|.. || 
tqlplshtaadfwqmiieqkvkcvlllltdseydk..lggdsvfprnqdflkfeersir.vgefkrvelgdgwvlkvlsvsngdyks.flhvhhykawph

HGVPADPGCvlNFLQDVNTRQSHLAQAGEKPGPICVHCsAGIGRTGTFIVIDMIldQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHY
  .|.|     .|....   || | .  .   .. .   .| ||.||| ...    ..     .. .|. . ...||  |   ||  .|. .||  .  .
nsipsdgsp..kfvkqiwqlqsvlrkysdstptvymsl.sgcgragtfalfeta..hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh

I
.
v
subfamily_PTPN14_pd Subfamily PTPN14 320-396 1.7e-10 35.4 In-house 18-91 (300) alignment 
Range on Protein: 320-396
Range on HMM: 18-91/300.0
EQLVKGGFWEEFESLQQDSRDTFSrNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvaGAEYINANYIRLPTDGD
..| .|  . |.| ... . |.   . .  .||  |||....|||...||.|   ...    .||||  |. .  | 
kkleegkvfteyeripkkredall.staklpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggk
0037934 (Phosphotyrosine protein) phosphatases II 346-402 1.7e-10 36.4 In-house 4-51 (243) alignment 
Range on Protein: 346-402
Range on HMM: 4-51/243.0
EGYKQENRLKNRYRNILPYDHTRVKLldvehsvAGAEYINANYIRLPtdGDLYNMSS
 . ..||. ||||..||||||.||||        |  |||||.|. .  . |. .. 
iallpenlsknrysdilpydhsrvkl.......egsdyinanliyvt..prliatqg
0042113 (Phosphotyrosine protein) phosphatases II 346-393 1.9e-10 36.0 In-house 3-49 (245) alignment 
Range on Protein: 346-393
Range on HMM: 3-49/245.0
EGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYIRLPT
 ....||. ||||..||||||||||| ....   .  ||||.|. .. 
vallpenkdknrysdilpydhtrvklspdgg.dldsdyinasyvdgyr
subfamily_ptpA1_pd Subfamily ptpA1 329-389 2.2e-10 34.9 In-house 25-83 (418) alignment 
Range on Protein: 329-389
Range on HMM: 25-83/418.0
EEFESLqQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsVAGAEYINANYI
|||  | ..|      .|| |. |  |||| |||| .||||.|  ..    |..|||||||
eefrll.eesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqd.kegsdyinanyi
subfamily_PTPDC1_pd Subfamily PTPDC1 632-744 9.5e-10 33.2 In-house 80-174 (182) alignment 
Range on Protein: 632-744
Range on HMM: 80-174/182.0
ARRIFHYHFQvWPDHGVPAdpgcVLNFLQDVNTRQSHLaqageKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldtEIDIQRTIQMVRSQRSGLVQT
.. |..| |  |.|.||..    . . |. |   .. |     . | . ||| || ||||  |   ..  .        ... ...|..|||.|.  .||
eqgiyvynfg.wkDygvas....leriLdivkvvafal.....qegkvavhChaGlGrtGvliacylvyak........rltaekaiklvrskrpksiqt

EAQYKFVYYAVQH
  | ..|    ..
reqvelvkefalf
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 322-391 9.7e-10 32.9 In-house 21-87 (315) alignment 
Range on Protein: 322-391
Range on HMM: 21-87/315.0
LVKGGFWEEFESLQQDSRDTFsrNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIRL
  | || ...||.       .  .   | ||. |||| ||..||..||.|  .|    ...|.|||.|  
stkngfkqdyesipggqlhpl..dvakkienkqknryiniiaydksrvqlpllend.phsdyvnanfidG
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 327-391 9.9e-10 32.7 In-house 21-82 (315) alignment 
Range on Protein: 327-391
Range on HMM: 21-82/315.0
FWEEFESLQQdsRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLlDVEHSVAGAEYINANYIRL
| |||  | .   |.. .. . ...|  ||||.||||.|..|||| .|       .|||| ||. 
fseefhdlpd..PdiyrqrvaretinfkknryknilPldsarvkl.eviddsPdsdyinasyiks
Y_phosphatase Protein-tyrosine phosphatase 352-392 1.5e-09 33.0 Pfam-A 1-38 (235) alignment 
Range on Protein: 352-392
Range on HMM: 1-38/235.0
NRLKNRYRNILPYDHTRVKLldvEHSVAGAEYINANYIRLP
|. ||||..|||||.|||||   ..|    .||||||... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgy
Y_phosphatase Protein-tyrosine phosphatase 352-392 1.5e-09 33.0 In-house 1-38 (235) alignment 
Range on Protein: 352-392
Range on HMM: 1-38/235.0
NRLKNRYRNILPYDHTRVKLldvEHSVAGAEYINANYIRLP
|. ||||..|||||.|||||   ..|    .||||||... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgy
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 681-742 2.1e-09 31.6 In-house 2-60 (69) alignment 
Range on Protein: 681-742
Range on HMM: 2-60/69.0
VHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
||||.| ||||||| | . . .|  . |   .||   .| .|  |  .|  | .| |.. |.
vhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 680-742 2.4e-09 31.5 In-house 2-61 (69) alignment 
Range on Protein: 680-742
Range on HMM: 2-61/69.0
CVHCSAGIGRTGTFIVIDMILDQIVRNGLdteIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAV
 ||||.| ||||||| | . . .|  . |   .||   .| .|  |  .|  | .| |.. |.
vvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 349-395 2.6e-09 31.4 In-house 30-73 (297) alignment 
Range on Protein: 349-395
Range on HMM: 30-73/297.0
KQENRLKNRYRNILPYDHTRVKLLDVehsVAGAEYINANYIRLPTDG
..    |||||.|| .| |||||| |   ... .||||.|. .| . 
rnsslrknryrdilatddtrvkllrv...iterdyinadyvvfpdee
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 327-390 3.8e-09 31.3 In-house 36-98 (319) alignment 
Range on Protein: 327-390
Range on HMM: 36-98/319.0
FWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVeHSVAGAEYINANYIR
.. ||  . . . .   ..    ..|. |||. |||..|...|||  .   . ...|||| .. 
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerl.iGeefsdyinasfvt
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 557-755 4.1e-09 29.5 In-house 128-314 (346) alignment 
Range on Protein: 557-755
Range on HMM: 128-314/346.0
VNTVTDFWNMVWQENTRVIVMTTKEyERGKEKCARYWPDEGRSEQF-GHARIQ----CVSENsTSDYTLREFLVSWRDQPARRIfHyHFQVWPDHGVPAD
   | ||| |..||. ... .   . .. |.  .  . ||    |. |.  |.     || .   .||.  .     |    .. | |   |     |  
esfvedfwymiyqeqihlvylmvpd.dklkntttslfndenggyqytgkmfinnrradvsgd.pkeytievlpegnsdsvicqv.h.hhapwkhlqqppk

PGCVLNFLQDVNTRQsHLAQAGekpgpICVHCSAGIGRTGTFIVIDMILDQIvRNGLDTeiDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIqtliA
   ..... .  . .  . .||     .||    | ||. .||     ..|.  ||..   .|   .. .. || | |.. |||  .|  |  ||    |
tlpiikmihqflsek.qvqnag.....vcvvslfgcgracsfigalyainql.nngiep..niceimknikqqrpggvesfaqyasiyaivfdyi....a

RKRA
||| 
rkrg
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 323-390 8.5e-09 29.7 In-house 18-85 (290) alignment 
Range on Protein: 323-390
Range on HMM: 18-85/290.0
VKGGFWEEFESLQQdSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDV-EHSVAGAEYINANYIR
 . || ..|..|.. .   .. . |  ..|.|.||..||..||  |. | .. .|     ||||| || 
gnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik
subfamily_PTPN23_pd Subfamily PTPN23 325-390 1.5e-08 28.8 In-house 15-76 (288) alignment 
Range on Protein: 325-390
Range on HMM: 15-76/288.0
GGFWEEFESLQQ-DSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLdvehsVAGAEYINANYIR
... ..|. |.| . ... .|     . .  |||.|.||||||.||||          .|||| ...
taldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfvk
subfamily_PTPN9_pd Subfamily PTPN9 315-389 1.8e-08 28.8 In-house 6-78 (297) alignment 
Range on Protein: 315-389
Range on HMM: 6-78/297.0
INARVEQLVKGGFWEEFESLQQDSR-DTFSRNegYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYI
. | |..  | |  .|.. ... .   || .    .. |  |||| ..| ||.|||.|  |..    ..|||||..
lvayvkekgkrGlskeyaeirnepveGtflas..klranleknrytdvlcydetrvvlakvded.easdyinanfv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 343-390 1.8e-08 29.2 In-house 16-62 (284) alignment 
Range on Protein: 343-390
Range on HMM: 16-62/284.0
SRNEGYKQENRLKNRYRNILPYDHTRVKLLDVeHSVAGAEYINANYIR
 ..    ..|. |||. .||..|...|||  .   . ...|||| .| 
dqtfanldqnkdknrighilafdknvvklerl.iGeefsdyinasfit
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 325-391 2e-08 28.8 In-house 23-86 (325) alignment 
Range on Protein: 325-391
Range on HMM: 23-86/325.0
GGFWEEFESLQqdSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLdVEHSVAGAEYINANYIRL
 ||  ||. |   | |. ...   | ||. |||..|....|..|| |    .  . ..||||.|.| 
dgfahefgllp..sddgiakkvamkpenkaknrfknvvaldksrvvle.tkkddpssdyinasylrd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 350-390 2.2e-08 27.9 In-house 45-84 (440) alignment 
Range on Protein: 350-390
Range on HMM: 45-84/440.0
QENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYIR
 .|..|||||||| |||.|| | .|. .|  ..|||| || 
pnnkvknryrnilaydhsrvmleevk.gvpdsdyinasyin
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 343-390 2.3e-08 28.5 In-house 42-88 (297) alignment 
Range on Protein: 343-390
Range on HMM: 42-88/297.0
SRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIR
.     |. |  |.||.||||||  ||||  |...   ..|.|| ...
pqtvaekkvnfeksRYkniLPydssRvkLaivndd.pdsDyvnasfvk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 348-390 3.1e-08 27.2 In-house 39-80 (515) alignment 
Range on Protein: 348-390
Range on HMM: 39-80/515.0
YKQENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYIR
 .. |  ||||.|||||| .||||  ..      .|.|| ||.
qeeinfkknryknilPydsvrvklevin.dnPhsdyfnasyip
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 351-390 3.4e-08 27.8 In-house 19-57 (270) alignment 
Range on Protein: 351-390
Range on HMM: 19-57/270.0
ENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIR
 ..  |||..|||  .|||.| ..|.    ..||||||.|
rgkklnRyadiLPsPatRvrleeleed.sataYinAnyvr
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 347-401 3.5e-08 28.0 In-house 4-57 (250) alignment 
Range on Protein: 347-401
Range on HMM: 4-57/250.0
GYKQENRLKNRYRNILPYDHTRVkLLDVEHSVAGAEYINANYIRLPTDGDLYNMS
. | .|. |||| .|...|..|| .|  |..   ..|||| ..   .. ... ..
akkpqnkeknryadiialdssrv.vLekekgdkesdyinasflhgyderkafiat
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 329-390 4.5e-08 27.0 In-house 17-75 (244) alignment 
Range on Protein: 329-390
Range on HMM: 17-75/244.0
EEFESLQQDSRDTFSRNeGYKQENRLKNRYRNILPYDHTRVKLLDVEhsVAGAEYINANYIR
||| .| . .|. .  |      |  |||| ||||.|.||| |   .    |..|||||||.
eefvglsdhtreflqtn.avlsanatknryinilpfdetrvilsssk..kegsdyinanyiq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 350-392 1.1e-07 26.3 In-house 26-68 (274) alignment 
Range on Protein: 350-392
Range on HMM: 26-68/274.0
QENRLKNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLP
  .  ||||..||| ...|| |   . .   ..|||||||. .
fgsqtknryktilPnensrvllesessededssyinanyikGy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 327-402 1.2e-07 25.5 In-house 22-97 (439) alignment 
Range on Protein: 327-402
Range on HMM: 22-97/439.0
FWEEFESLQQDSRDTFSRNEG-YKQENRLKNRYRNILPYDHTRVKLLDVEhSVAGAEYINANYIRLPTDGDLYNMSS
| |.||...  | |         .. .. ||||... ..||||| | ..   |  . |||||||.   | .||  . 
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeip.gvphshyinanyikGyyddklyiatq
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 324-389 1.8e-07 25.4 In-house 19-79 (287) alignment 
Range on Protein: 324-389
Range on HMM: 19-79/287.0
KGGFWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHsvagaEYINANYI
. || . |  |.| ...  .   .  ..|. |||...||..|  || | . ..     .|||| .|
negfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehp.....dyinavfi
subfamily_PTPRN_pd Subfamily PTPRN 329-389 2.2e-07 24.9 In-house 33-92 (297) alignment 
Range on Protein: 329-389
Range on HMM: 33-92/297.0
EEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLlDVEHSVAGAEYINANYI
.|.|.| .   .  ... . ...|  |||....|||||.|||| . | |    .||||  |
kewealcayeaepstkevakaeknvkknrskavlpydhsrvkl.keeasaeksdyinasai
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 581-736 3.7e-07 23.9 In-house 142-292 (332) alignment 
Range on Protein: 581-736
Range on HMM: 142-292/332.0
EYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPARRIFhYHFQVWPDHGvpADPGCVLNFLQDVNTRQSHL-AQAGEKPGPI
| |   . | ..||...  ..|    ||.  . | .     .. |. . |  . ..  ||  | |      |  .|..   .. .  .   ..|   |||
ecelkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvl.mhfyewadas..klpeymldmrasiklqyirsskktgvcigpi

CVHCSAGIGRTGTFIVIDMILDQIVRnglDTEIDIQRTIQMVRSQRSGLVQTEAQYK
 . |..|. .   .  ||.|. .|     .  . .. |.  .. || | ..|   | 
mlvcatgvekcaisatidiivsrite...ehrvgfketmsaikmqrfgcfrtvgpys
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 638-747 3.9e-07 23.9 In-house 232-339 (347) alignment 
Range on Protein: 638-747
Range on HMM: 232-339/347.0
YHFQVWPDHGVPADPGCVLNFLQDVNTRQS-HLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQIVRnGLDteIDIQRTIQMVRSQRSGLVQTEAQYK
|    || .  | |   || ...      |  |    ||  |. | |  |. |. | ..  .|..|..  |     | .  .. .| ||.|.      | 
yncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvld.gkt..pdcddlfkkmrdqragvftmsifyt

FVYYAVQHYIQ
.   |   |..
yairaalfylk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 351-398 6.3e-07 23.8 In-house 2-45 (237) alignment 
Range on Protein: 351-398
Range on HMM: 2-45/237.0
ENRLKNRYRNILPYDHTRVKLLDvehSVAGAEYINANYIRlPTDGDLY
||..|||| ||  |||.|| |     . .|..||||.|..   ||   
enkiknrygnivaydhsrvvlkg...agsgsdyinatylk.gfdgtpk
0048567 (Phosphotyrosine protein) phosphatases II 638-699 9.3e-07 23.4 In-house 40-100 (157) alignment 
Range on Protein: 638-699
Range on HMM: 40-100/157.0
YHFQVWPDHGvPADPGCVLNFLQDVNTRQShlaQAGEKPGPICVHCSAGI---GRTGTFIVIDMI
...  . |.| | . ... .| . .|   .   .  .....|.|||.||    |||.|.|   .|
vyedfffdfG.PlnlailyrFilklnkflk...ilelagkaiavhckaglkkrgrtatLigcYli
PTEN_1 643-740 1.7e-06 23.0 In-house 102-187 (196) alignment 
Range on Protein: 643-740
Range on HMM: 102-187/196.0
WPDHGVPAdpgcvLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMIldqivRNGLdteIDIQRTIQMVRSQR-SGLVQTEAQYKFVYY
..|||.|      |..|.|.  .  . ... .. . . ||| ||.||.|| .   ..     . |     . . ....||..|  | ...  | ....|
ieDhgaps.....lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLm.....ykgk...ltadeAlelvrekRppgapnspsqerlley
0049772 (Phosphotyrosine protein) phosphatases II 343-392 2e-06 23.3 In-house 37-83 (314) alignment 
Range on Protein: 343-392
Range on HMM: 37-83/314.0
SRNEGYKQENRLKNRYRNILPYDhTRVKLlDvEHSVAGAEYINANYIRLP
..  ... .|| |||| .|||.| .||.| .   .| |  ||||.|.. .
tilvadlflnrdknryldilpad.nrvil.p.glpvsgsdyinasyvdgf
subfamily_PTEN_pd Subfamily PTEN 666-744 2.2e-06 22.8 In-house 106-178 (184) alignment 
Range on Protein: 666-744
Range on HMM: 106-178/184.0
QSHLAQAGEKpgPICVHCSAGIGRTGTFIVIDMILDQIVRNGLdteiDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQH
...|..  ..   . ||| || ||||. ||  ..  .....      .. .  . .|.. .  |.  .| ..|.|  . 
ekwleedkkn..vvvvHCkaGkGRtGvlivayllkslllekae....ealelfaeaRtknkkgvtiPsqrRYveYyekl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 352-392 2.4e-06 21.1 In-house 48-101 (349) alignment 
Range on Protein: 352-392
Range on HMM: 48-101/349.0
NRLKNRYRNILPYDHTRVKLLDVEHSVAGA-------------EYINANYIRLP
   ||||..||||.|.||||    .| ...             .||||||..|.
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylklt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 537-614 2.6e-06 21.0 In-house 107-172 (349) alignment 
Range on Protein: 537-614
Range on HMM: 107-172/349.0
ReremfkTYIATQGCLltqqVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQfgHARIQCVSENS
.       |||||  |      || ||....  .. ....  ... | . ||| .|| .   |.   . ..|  |...
k......kyiatqaPl....PstvddfykvillngvklvlsLnddkelslekcdiywqelsysni..tvklqnsslyi
subfamily_CG7180_pd Subfamily CG7180 346-389 3e-06 21.1 In-house 36-78 (296) alignment 
Range on Protein: 346-389
Range on HMM: 36-78/296.0
EGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYI
 |...||| |||. ...|||..|| |  ..   .  .|||| |.
gglrkenreknrdvkvvPyDynRvvLekldGe.eksdYinavyv
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 349-390 3.1e-06 21.5 In-house 5-45 (239) alignment 
Range on Protein: 349-390
Range on HMM: 5-45/239.0
KQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIR
|. |. |||| ||. |||.|| |  .      ..||||.|.|
krvnkaknryanivtydhsrvvleklsnd.phsdyinasylr
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 322-390 3.5e-06 20.9 In-house 12-79 (301) alignment 
Range on Protein: 322-390
Range on HMM: 12-79/301.0
LVKGGFWEEFESLQQDSRDTfsRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEH-SVAGAEYINANYIR
  . .| |....|.. . ..   . |...||.  ||..|| .||. |. |   .. ...  |||||.|| 
khsnkfeeqykelkegedks..ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 325-390 3.7e-06 21.3 In-house 22-83 (305) alignment 
Range on Protein: 325-390
Range on HMM: 22-83/305.0
GGFWEEFESLQQDsRDTFsrNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSVaGAEYINANYIR
 |. ....||...  ...  . | |..|. |||...| ..|. |..|   |.    ..||||.|. 
kgleaqykslyee.eesi..dvgkkeankaknrlkeitlldddriiltekesld.dsdyinasyvd
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 349-390 3.8e-06 21.2 In-house 4-44 (239) alignment 
Range on Protein: 349-390
Range on HMM: 4-44/239.0
KQENRLKNRYRNILPYDHTRVKLLDVEHSvAGAEYINANYIR
|. |. |||| ||. |||.|| |  .      ..||||.|.|
krvnkaknryanivtydhsrvvleklsnd.phsdyinasylr
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 327-390 5.2e-06 20.7 In-house 8-66 (267) alignment 
Range on Protein: 327-390
Range on HMM: 8-66/267.0
FWEEFESLQQDSRDTFSRNEGYKQENRLKNRYRNILPYDHTRVKLLDVEHSvagaeYINANYIR
. .||| ... | ..      . ..|. .||. . ||||.||| | . |.      |||| |. 
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee.....yinasyve
DSPc Dual specificity phosphatase, catalytic domain 659-699 6.4e-06 21.1 Pfam-A 56-96 (133) alignment 
Range on Protein: 659-699
Range on HMM: 56-96/133.0
LQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMI
 .. .   . ...| .| . . ||| ||| |..|.|.  ..
skeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm
DSPc Dual specificity phosphatase, catalytic domain 659-699 6.4e-06 21.1 In-house 56-96 (133) alignment 
Range on Protein: 659-699
Range on HMM: 56-96/133.0
LQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMI
 .. .   . ...| .| . . ||| ||| |..|.|.  ..
skeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlm
subfamily_DSP23_pd Subfamily DSP23 669-740 6.7e-06 20.8 In-house 77-140 (148) alignment 
Range on Protein: 669-740
Range on HMM: 77-140/148.0
LAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldtEIDIQRTIQMVRSQRSGLVQTEAQYKFVYY
. .| ||   . |||  | |||||..   ..  .        ..    .|  || .| | |.|  | | |. 
veeaeekneavsvhcllgrgrtgtmlacylvker........klaaaeaiaevrrlrpgsvetveqeklvrd
PTPc_motif_SM00404 659-725 8.4e-06 20.7 In-house 63-121 (140) alignment 
Range on Protein: 659-725
Range on HMM: 63-121/140.0
LQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVIDMILDQivrngldtEIDIQRTIQMVRSQR
... .   . . .| .| | . ||| ||. |..|.|.  ..  .        .....  ...|...|
skyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryr........qlslaeayefvkerR