Gene Lar in Drosophila melanogaster

Synonym: CG10443, DLAR, DLar, Dlar, Dmel\CG10443, LAR, PTP38A, Ptp38A, dlar, lar, Dmel_CG10443, Lar

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRD
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP049_AA protein Get Run
DmelP049_AA_1459-1734 phosphatase_domain Get Run
DmelP049_AA_1746-2025 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 1454-1783 5.8e-164 541.8 In-house 2-332 (564) alignment 
Range on Protein: 1454-1783
Range on HMM: 2-332/564.0
HPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQ
..|||..|...|...||.|...||..||..||.||||||...| ..||.||||||..||||||| | .|||. |||||||...|||||..||.||||||.
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQ
||. |||||.|| ...||||.|.|||... ||..|||..||||||.. ||..|..|||.|.||||.| ..  .. ||..| .||.|||||||......|.
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLd

FLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLL
..|..|||..|..||..|||||||||||..||||.||||.|.|| .|||..|..||.|||.|||||.||||||.|||||. ||.|||...||..||||| 
lirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLa

ITEPGETISGMEVEFKKLS-NVKMDSSKFVT
 .|......|.|.||..|.  .... ..| .
eveedtemtgleleFqrLatakeieleefav
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1457-1771 7.1e-127 417.8 In-house 2-318 (318) alignment 
Range on Protein: 1457-1771
Range on HMM: 2-318/318.0
IPISEFANHIERLKSNDNQKFSQEYESIE-PGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQET
|.......|..||... . ..|.||| ..   ...|. .|. . || ||||||..||||.||.|  .||..||||||||| ||||...||.|.|.|| ||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

FVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFL
. ||||| || ..|.|||.|..|||...|...||| .|...||.. |...|. ||..| .|.|.. |.. .. |...| ..|.|||.|||...| .|...
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RRCRALT-PPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLI
|. ..   ... ||..||||||||||| .|..|..|||.|.|...|... |. || ||| ||||||||.||.|..|||...| ||| |..|......|  
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

TEPGETISGMEVEFKKL
..|    . |..||..|
qdpesgttemdaefqrl
subfamily_PTPRD_pd Subfamily PTPRD 1778-2030 7.5e-121 399.5 In-house 37-287 (564) alignment 
Range on Protein: 1778-2030
Range on HMM: 37-287/564.0
SSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQY
.... .|| |.||.|||. .|..|..||| |....| |||||.||||||||| | ||||.|||.... ||||||.||.||...||||||.|.|..|| .|
qftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkY

WPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRSGVFITL
||.... .|....|.. .|... .| .|.||...... .||.||||.|..||..|||.|.....|.| .|....|   . |||.|||||||||.|.||..
WPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..pdagPivVhCSaGVGRTGtfivi

SIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNY
...|||...|...|..|.|. ||.||.||||||.||.|...| ||.| .... 
damlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1456-1769 1.3e-113 374.3 In-house 4-319 (319) alignment 
Range on Protein: 1456-1769
Range on HMM: 4-319/319.0
PIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQET
.|.. |.......|.|. .... .|.. .. ....|.|... |.||.|||| |. |||..||.|....|| |||||||.. |||.......|||.||..|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

FVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLcRQGFNDR--REIKQLQFTAWPDHGVPDHPAPFLQ
. ||||| || .. ..||.|.| |. ..|. .|||.   |.||.. ||. | .||. | || ..| ..  ..   ||.|. |.|.||||.||..    |.
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslld

FLRRCR-ALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKL
.|.| | .   ..|||..||||||||||| .||.| ||||.|.| ..|..  |  ||.||| |||...||.||..|.|||. .| ||.  ..|.. |..|
llkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkql

LITEPGETISGMEVEFK
   ...   .|.| ||.
aekvadtgetglerefq
subfamily_PTPRG_pd Subfamily PTPRG 1457-1747 8.2e-111 365.9 In-house 1-301 (563) alignment 
Range on Protein: 1457-1747
Range on HMM: 1-301/563.0
IPISEFANHIERLKSNDNQKFSQEYESIE---PGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGS-DYINANYCDGYRKHNAYVATQGPL
.|..|||.|.  |.......||.|.|...     .... . |. ..|| |||| |..|||.|||.|  . |. .. ||||||| |||.|..|..||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

QETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCR------QGFNDRREIKQLQFTAWPDHGVPD
..|| ||||| || ..|.|||.| |.||.| |||.|||. ..||||.. ||..|.. ||.|..||...        .  .. ....| ..| |||||||.
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

HPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLH
|..| |.| ..  | .. | ||..||||||||||| |||.|..|.....|......| .  .|||||..||||.||||.|||.||||  . ||. | ...
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

T
 
e
subfamily_PTPRA_pd Subfamily PTPRA 1453-1768 1.2e-107 354.6 In-house 10-330 (330) alignment 
Range on Protein: 1453-1768
Range on HMM: 10-330/330.0
SHPPIPISEFANHIERLKSNDNQKFSQEYESIEP-GQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGP
 ..|.|. .. . |.. ...||..| .|....     | | . .. | || |||. |.  ||.||| |. .|||  |||||| . |||.. . ..|.|||
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGP

LQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGF----NDRREIKQLQFTAWPDHGVPDH
..||  ||||| || |.|||||.| |.|| . || ||||. |. |||.| |.. ....|  |..| | . ...     .. | ..|. ||.||| ||| .
keetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfe

PAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHT
|   |..|.. ..| . ..||..||||||||||| .||.|..|||.| |...|... |  ||.||  ||||. || ||. ..||  . | ||. .  | .
piGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslek

HLQKLLITEPGETISGMEVEF
|||||  . .| .  |.| ||
hlqklynkitgtdkigleeef
subfamily_PTPRK_pd Subfamily PTPRK 1454-1768 1.4e-107 354.2 In-house 1-312 (314) alignment 
Range on Protein: 1454-1768
Range on HMM: 1-312/314.0
HPPIPISEFANHIERLKSNDNQKFSQEYESIEPGqqftWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQ
|| | . .  ..|  || ...  | .||||.  |    || .. ..|..|||. .. |||.|||.| ...|   ||||||.. |.|.. .|...||||||
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTEtYGQIFVTITETQELATYSIRTFQLCR--QGFNDRREIKQLQFTAWPDHGVPDHPAPF
||  ||||. .. ..|.|||.| | | .|.|| .|||  ..  ||.| |.. ||. || . .|.|....  .| ...||..|.||..||||.|| .   .
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

LQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQK
|...||  . ...| |...|||||| ||||..|.||..|. ...|...|..  |  ||...  ||.||.||.||.|.|||| .|| | .|. ....   .
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyle

LLITEPGETISGMEVEF
 .  .|    | .. ||
sirldpqtnssqlkeef
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1763-2032 4.2e-106 349.6 In-house 21-288 (318) alignment 
Range on Protein: 1763-2032
Range on HMM: 21-288/318.0
GMEVEFKKLSNVKMDSSKFVTaNLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVM
 .. |...|| ..  .... . . |.||.||| . ||.|...|| |....| |||||.||..||||| . ||||||.|. .. ||||||.|| ||...||
llseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivm

LTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQdGPITV
||...| |..|. .||| . |  |.  ||.   | .. .| |||||||     .||.|||... .||..|||.|| ...|...||.|.... |. |||.|
ltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga.gpivv

HCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNYTN
|||||||| ||||...|.|||.. |...||||||. ||.||..||||||||.|.| . ||.| |.| ...
hCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_PTPRB_pd Subfamily PTPRB 1456-1733 3.8e-105 346.1 In-house 6-285 (293) alignment 
Range on Protein: 1456-1733
Range on HMM: 6-285/293.0
PIPISEFANHIERLKSNDNQKFSQEYESIEP-GQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQE
|| ...|..|....|.... .||.|||...  |.. . . ..|. |..|||| |. .||||||.| |...  ||||||||| .||. .. ..|||||| |
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR-GTETYGQIFVTITETQELATYSIRTFQLCRqgFNDRREIKQLQFTAWPDHGVPDHPAPFLQ
|. |||||.|| |. .|||.|.| |. ..||..|||.   . .||.| ||.....||  . ||......   ...|...|..||.|||||||......|.
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlld

FLRRCRALT--PPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
|.|. |  .    ...|..||||||||||| .| .| .|.....| ..||.| |. || .||..||||.||||||...|. .
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0040438 (Phosphotyrosine protein) phosphatases II 1461-1772 8.8e-105 345.7 In-house 4-315 (317) alignment 
Range on Protein: 1461-1772
Range on HMM: 4-315/317.0
EFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFW
.. .....|. .|......|.| .   .  |.. ..|. ||.|||| ..  ||||||.|  ..|. .||||||.| ||... ....||||||..|. |||
dlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRA
||.||... .|||.|.|||. |.||.||||...| |||...||.....||| . .||...   | .. |.......|.|||||||..| ..|.||...|.
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

LTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLITEPGET
  ....|||.|||||||||||..|... |||....|. .|..  |  ||.||...|||..||.|..||.|| . ...| .|| .|...|.||||. ... 
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplaldd

ISGMEVEFKKLS
 ...| |.| |.
vklkekelklll
0051299 (Phosphotyrosine protein) phosphatases II 1454-1733 2.8e-101 334.0 In-house 2-286 (288) alignment 
Range on Protein: 1454-1733
Range on HMM: 2-286/288.0
HPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQ-QFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPL
. .|...|.......|. |.. .. .|.| . . . ..|.  ..|..|..|||| .. .||||||.|  ..|| |||||||.| |||.. ....||||||
dteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPl

QETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQ----GFNDRREIKQLQFTAWPDHGVPDHP
..|. |||||.|| .. .|||.|.|.|. |.||.||||..|..|||.|.||......|..| .||... .     | .  |.......|.||||||||.|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdsp

APFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
 ..|.|||..|   .. .|||.|||||||||||..|..| .||....|. .|... |  || ||..||||..||.|...|.||..
ellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 1447-1738 4.4e-100 330.2 In-house 16-304 (308) alignment 
Range on Protein: 1447-1738
Range on HMM: 16-304/308.0
QTPGMISHPPIPISEFANHIERlkSNDNQKFSQEYESIEPGQQ-FTWDNSNLEHNKSKNRYANVTAYDHSRVQLpaveGvVGSDYINANYCDGY--RKHN
 |. . |. .... ......|.   .|......|.| .   .  .... ..|. ||.|||| .. .|||||| |    .  |||||||.| |||  .. .
dtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklpr

AYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR---GTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWP
...||||||..|. |||||.|| .. .|||.|.|.|. |.||.||||.    |...||...||......|..| .||..|.  | .. |.......|.||
kfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp

DHGVPDHPAPFLQFLRRCRALTppESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVT
|||||..|...|.||...|     ..||..|||||||||||..|..| .||....|. .|... |  || ||..||||..||.|...|.|| . . .|
dhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0051299 (Phosphotyrosine protein) phosphatases II 1738-2024 4.5e-100 330.1 In-house 3-286 (288) alignment 
Range on Protein: 1738-2024
Range on HMM: 3-286/288.0
TEVPARNLHTHLQKLLitepGETISGMEVEFKKLSNVKMDsSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAA
||.....|. ...|||       ..|.. ||..| ....|  .. .|.||.|..||| ..||||..|||.|....|.|||||.|||.||||..  ..||.
teisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIat

QGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDA----RDGSSRTVRQFQFIDWPEQGV
||| ..  ||||||.||.|....|||||| |.|||||.|||| . |. |  ..|  . |. .. |..|...||.      || ||||..|....||..||
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

PKSGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
| | | ..||. .|.|  .   ..||. |||||||||.|.||.| ..||....||..||...|. ||.||| ||||..|| |.|.|.||||
pdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0050432 (Phosphotyrosine protein) phosphatases II 1755-2029 4.3e-99 327.0 In-house 35-304 (308) alignment 
Range on Protein: 1755-2029
Range on HMM: 35-304/308.0
TEPGETISGMEVEFKKLSNVKMdSSKFVTANLPCNKHKNRLVHILPYESSRVYLtpihGiEGSDYVNASFIDGY--RYRSAYIAAQGPVQDAAEDFWRML
 |.   ....| ||..| .||  . .. .|.||.||.||| ..||||..|||.|    . |||||.|||..|||  ... ..||.||| ..  ||||||.
lekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmv

WEHNSTIVVMLTKLKEMGREKCFQYWPHE---RSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHK
||.|....|||||| |.|||||.|||| |    |..| ...|  . |.... |..|....|. .|| ||||..|....||..||| | | ..||. .|.|
weqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrk

TKeqfgQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDN
.     ..||| |||||||||.|.||.| ..||....|| .|||..|. ||.||| ||||..||.|.|||.|||| .. .
sl....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1468-1740 8.2e-99 325.6 In-house 20-297 (298) alignment 
Range on Protein: 1468-1740
Range on HMM: 20-297/298.0
RLKSNDNQKFSQEYESIEPGQQ----FTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMC
  |...  ....|.. .. ...    .... .. ..||.|||||.. |.|.||| | ....   |||||| . ..|...||..|||.||.||..||||| 
vkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAlTP
.| . .||||.| |||  ..|. .|||..|.||||.| |.. ...| | . .|.... ..  ...||..||.|| |||.||| .    |..||. || ..
teedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sq

PESG--PVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEV
 ..|  ||||.|||||||.| .|.|||.|||.|.|. .|..  |  ||..|  .||||.||.||..|.|||. .. .|.
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1763-2028 1.1e-95 315.4 In-house 24-287 (319) alignment 
Range on Protein: 1763-2028
Range on HMM: 24-287/319.0
GMEVEFKKLSNVKMDssKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVM
..| |||.|.. . |  .| .|. . ||.|||   ||.|. .|| |....|.|||||.||||||||. |...||.|.|.... ||||||.||..| ||||
llekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvm

LTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGS-SRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPIT
||||.| .. |. .|||.|  ..|  ..|..  | .. .|  |..|.  . .   .|.| .||. .||...||... . .|......|..|.  |.|||.
ltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek.tqsgPiv

VHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFD
||||||||| | ||.|...|||.. |||||||.||. || ||. |||...||.|.| | ||.. ..|
vhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0040438 (Phosphotyrosine protein) phosphatases II 1763-2025 1.5e-95 315.4 In-house 19-277 (317) alignment 
Range on Protein: 1763-2025
Range on HMM: 19-277/317.0
GMEVEFKKLSNVKMDssKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVM
... ||..| ..| |   . .|.||.||.||| ..||||..|||.|.|. |...|||.|||..||.... ..||.||| ..  ||||||.||...|..||
alleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPITV
||.|.|.|||||.||||.. .. |  ..|  . |. .. ..||...|.| .|. ||||..|....||..|||.| . ..||. .|..  |  ...||. |
LteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale..dpggpvlV

HCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLG
||||||||.|.||.. ..||....|| .||...|. ||.||| .|||..||.|.|.|.|||| 
HCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylk
0046845 (Phosphotyrosine protein) phosphatases II 1763-2028 3.3e-95 314.0 In-house 1-278 (284) alignment 
Range on Protein: 1763-2028
Range on HMM: 1-278/284.0
GMEVEFKKLSNVKMDSS-KFVTANLPCNKHKNRLVHILPYESSRVYLTPIHG-IEGSDYVNASFIDGY-----RYRSAYIAAQGPVQDAAEDFWRMLWEH
|.| ||..| ..... . .. .|.||.|..||| ..||||..|||.|....| .|.|||.|||..|||     ... ..||.|||...  ||||||.||.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NSTIVVMLTKLKEMGREKCFQYWPHER-SVRYQYYVVDPIAEYNMPQYKLREFKVTDAR-DGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQ
|....||||.| |.|||||.||||.|  ...|  . |  . |.... |..|....|.   .| ||||..|....||..||| | | ...|. .|..  |.
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

FGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEG---VLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFD
....||| |||||||||.|.||.| ..||....||   ..||...|. ||.||| ||||..|| |.|.|.|||| .. 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0043336 (Phosphotyrosine protein) phosphatases II 1456-1731 4.9e-95 313.4 In-house 1-275 (278) alignment 
Range on Protein: 1456-1731
Range on HMM: 1-275/278.0
PIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQET
||...........|. |.......|.|..   . .|.. ..|..||.|||| .. .||||||.|  ..|. .||||||.| |||.. ....||||||.||
pisvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

FVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPtRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFL
. |||||.|||.. ||||.|.|.|. |.||.|||| .|..|||...|| .....|..| .||. . . | .  |.. ......|||||||......|.||
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldfl

RRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
.. |   ....|||.|||||||||||..|... .||....|. .|..  |  || ||  .|||..||.|...|.||
kavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1456-1752 7.5e-95 312.6 In-house 3-302 (305) alignment 
Range on Protein: 1456-1752
Range on HMM: 3-302/305.0
PIPISEFANHIERLKSNDNQKFSQEYESIEPGqQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQET
.| ....|..|.  ........ ..|.|.    . . |  . |.||.|||....| .|..|..| . | .  ||||||.| |||.....|...||||..|
iialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlknt

FVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTE--TYGQIFVTITETQELATYSIRTFQLCR-QGFNDRREIKQLQFTAWPDHGVPDHPAPFL
 .||||. .| |. ||||.|.| |  . || ||||.. ||   .|.. |....... . | .| ....  .. .. | . |.|.| |||||||. .. .|
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsll

QFLRRCRALTPPESG-PVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQK
....| .     . | |..||||||||||| .|..| .|||.|.|...|... .  || .| .|||| ||| |.|||. | |.|| |..   ||. ...|
slikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarvnk

L
|
l
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1736-2031 1.6e-94 311.6 In-house 1-297 (298) alignment 
Range on Protein: 1736-2031
Range on HMM: 1-297/298.0
GVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLSNVKM--DSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSA
| ||. |..|...||||   .. ....|.. ||..|..|.   .. .   |. | ||.|||   |....|||| |. ... | |||.||||...|. |.|
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGV
.||.|.|.. . ||||||..|.... .||||.|.|... |. .|||.|.. .|    |.  ..... ..  |..||....  ..|.|||..|. ||..||
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PKSGEGFIDFIGQVHKTKEQFGqDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNYT
|.  .  .|.. .|.....| | . |..|.||||||||| || .. ||||.. | |.||||.|..|| .||..||||.|| |.| | ||.| ||... 
penatsvldllrkvrasqqqag.nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0036941 (Phosphotyrosine protein) phosphatases II 1468-1749 2.3e-94 311.3 In-house 6-293 (297) alignment 
Range on Protein: 1468-1749
Range on HMM: 6-293/297.0
RLKSNDNQKFSQEYESIEPGQ-QFTWDNSNLEHNKSKNRYANVTAYDHSRVQLpaveGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWEL
  |.........|.|.. | . ..... ..|. |..|||| .. .|||.||.|    .  |||||||.| |||.  ....||||||..|. |||||.||.
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

KTATIVMMTRLEERTRIKCDQYWPTR--GTETYGQIFVTITETQE--LATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALT
.. .|||.|.|.|. |.||.||||.   .. |||...|| .....  |..| .||...   | .. |.......| |||||||..||..|.|....|   
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

PP--ESGPVIVHCSAGVGRTGCYIVIDSMLERMK---HEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHL
.   ..|||.|||||||||.|..|..| ||....   .|. .||.  |  || ||. .|||..||.|...|.|| . .. | .|...|...|
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvlll
0039614 (Phosphotyrosine protein) phosphatases II 1754-2028 6.1e-94 310.1 In-house 24-293 (297) alignment 
Range on Protein: 1754-2028
Range on HMM: 24-293/297.0
ITEPGETISGMEVEFKKLSNVKMDsskFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGI-EGSDYVNASFIDGYRY-RSAYIAAQGPVQDAAEDFWRM
  |.   ..... ||..| ..| |   ...|.||.||.||| ..||||..|||.|.|. |  ..|||.|||..|||..   ..||.||| ..  ||||||
llekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrm

LWEHNSTIVVMLTKLKEMGReKCFQYWPHERSvRYQYYVVDPIAEYNMPQYKLREFKVTDarDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTK
.||...|..||||||.|.|| ||.||||.| . .|  ..|  . ..  . |..|...||.  .| ||||..||...||. ||| | | ...|. .|..  
vweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreal

EQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFD
.. ...||. |||||||||.|.||.. ..||....|| .||...|. ||.||| .|||..||.|.|.|.||.|  ..
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0047943 (Phosphotyrosine protein) phosphatases II 1758-2024 3.4e-93 307.3 In-house 8-272 (273) alignment 
Range on Protein: 1758-2024
Range on HMM: 8-272/273.0
GETISGMEVEFKKLSNVKMdSSKFVTANLPCNKHKNRLVHILPYESSRVYLtpihGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNS
   ..... ||..| ..|  . .. .|.||.||.|||  .||||..|||.|    | .||||.|||..|||..  ..||.||| ..  ||||||.||.|.
llgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

TIVVMLTKLKEMGREKCFQYWPHER---SVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQF
...||||.| |.|||||.||||.|    |..|  . |  . |.. . |..|....|.  .| ||||..|.. .||..||| | | ...|| .|.|. |..
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

GQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
 ..||. |||||||||.|.||.| ..|.....|| .||...|. |||||| ||||..|| |.|.|.||||
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPRA_pd Subfamily PTPRA 1767-2024 4.7e-93 306.7 In-house 37-295 (330) alignment 
Range on Protein: 1767-2024
Range on HMM: 37-295/330.0
EFKKLSNVKMDSsKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKL
||. |   ....  . .|.   ||.|||.|.||||. |||.|....|.| |||.||||||||. .  .|||||| ... ||||||.||..|. .||||.|
efnalPagpiqa.tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltel

KEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDAR----DGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQdgPITV
||  .||| ||||.| .| |    |    |  . .| .|.| |..      . .|| |||| |  ||. |||  . | .... .|.|...| ..  ||.|
kerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag..pivv

HCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
||||||||.| ||.|. ||||.. |...|||..|. || ||| ||||. ||.|.|.. ||| 
hcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
0046845 (Phosphotyrosine protein) phosphatases II 1477-1739 8.3e-93 306.1 In-house 2-280 (284) alignment 
Range on Protein: 1477-1739
Range on HMM: 2-280/284.0
FSQEYESIEPGQQF---TWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGV-VGSDYINANYCDGY-----RKHNAYVATQGPLQETFVDFWRMCWELK
. .|.| .   . .   ... ..|..|.||||| .. .|||||| |  ..|   .||||||.| |||     .......||||||..|. |||||.|| .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TATIVMMTRLEERTRIKCDQYWPTRG-TETYGQIFVTITETQELATYSIRTFQLCRQG-FNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTP--
. .|||.|.|.|. |.||.||||. | . |||...||......  .| .||..| . |  .  |.......|.|||||||..|...|.||| .| | .  
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

PESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEK---IIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTE
| .||..|||||||||||..|..| .||....|.    .|... |  || ||..||||..||.|...|.||.. ...| 
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0036941 (Phosphotyrosine protein) phosphatases II 1760-2028 1.3e-92 305.6 In-house 11-281 (297) alignment 
Range on Protein: 1760-2028
Range on HMM: 11-281/297.0
TISGMEVEFKKLSNVKMdSSKFVTANLPCNKHKNRLVHILPYESSRVYLtpiHGiEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTI
 ..... ||..| ...  . .. .|.||.|..|||  .||||...||.|   .. |||||.|||..|||..  ..||.||| ..  ||||||.||.|.|.
flalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl...dd.egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

VVMLTKLKEMGREKCFQYWPHE--RSVRYQYYVVDPIAEYN--MPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFG
.||||.| |.|||||.||||.|   |. |  ..|  . ..    . |.||...||| ..| ||||..|....||. ||| | . ..||| .|.|  ... 
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

QDGPITVHCSAGVGRSGVFITLSIVLERMQ---YEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFD
..||. |||||||||||.||.. ..|....   .|| .|....|. ||.||| .|||..||.|.|.| ||.| ...
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0043336 (Phosphotyrosine protein) phosphatases II 1759-2024 2.6e-92 304.5 In-house 17-277 (278) alignment 
Range on Protein: 1759-2024
Range on HMM: 17-277/278.0
ETISGMEVEFKKLSNVKMdsSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNST
   .... ||..| ..|     . .|.||.||.||| ..||||..|||.|... | ..|||.|||..|||..  ..||.||| ..  ||||||.||...|
nlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvt

IVVMLTKLKEMGREKCFQYWPhERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDG
..||||.|.|.||.||.|||| . |..|  ..|  . |. .. |..| ..||. .|| ||||.......||..||| | . ..||. .|..  |   ..|
tivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..dsng

PITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
|. |||||||||.|.||.| ..||....|| .|....|. ||.||| .|||..||.|.|.|.||||
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 1447-1738 3.6e-92 304.3 In-house 4-294 (297) alignment 
Range on Protein: 1447-1738
Range on HMM: 4-294/297.0
QTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQfTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGV-VGSDYINANYCDGYRK-HNA
 .. . ...|||.| .. .. ..| |..... .|.|..   .   .  ..|. ||.|||| .. .||||||.|  ..||  .||||||.| |||..  ..
lrdallesipiplsvldlllllekansktllllefeellslkp.dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrk

YVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRiKCDQYWPTRGTeTYGQIFVTITETQELATYSIRTFQLCRqgFNDRREIKQLQFTAWPDHGV
..||||||.||. |||||.||... .|||.|.|.|. | ||.||||..|. |||...|| .....|. | .||. . .   .  |.....|.| ||||||
fIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgv

PDHPAPFLQFLRRCRALTP--PESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVT
|.... .|.||. .|      |..|||.|||||||||||..|... |||....|. .|..  |  || ||...|||..||.|..||.|| . ...|
ppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0045450 (Phosphotyrosine protein) phosphatases II 1749-2024 4.5e-92 304.3 In-house 14-304 (307) alignment 
Range on Protein: 1749-2024
Range on HMM: 14-304/307.0
LQKLLITEPGETISGMEVEFKKLSNVKMD-SSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGI-EGSDYVNASFI--------DGYRYRSAYIAAQ
| .|. ... . ..|.. ||.|| .|. . . .. .|.||.||.||| ..||||...||.|....|  |.|||.|||..        |||.   ..||.|
llllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatq

GPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSV-RYQYYVVDPIAEYNMPQYKLREFKVTDA-RDGSSRTVRQFQFIDWPEQGVPKS
|| ..  |||||||||...|..||||.|.|.|||||.||||.|...  |  ..|  . |. .. |..| ..|||   .| ||||..|....||..|||.|
gPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps

GEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGV---LDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
 | ..||| .|.|  |. ...||. |||||||||.|.||.. ..|.....||.   .|....|. ||.||| .||...||.|.|.|.||.|
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
DSPc_SM00195 1476-1733 6.7e-91 299.6 In-house 1-262 (263) alignment 
Range on Protein: 1476-1733
Range on HMM: 1-262/263.0
KFSQEYESIEPGQ-QFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMM
|...|.|..|  . . . .... ..||||||| |.  |||.||.|.  |.  ||||||||| .|..| ..|.||||||..|. |||||.|| |. .|||.
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TRLEERTRIKCDQYWPTR--GTETYGQIFVTITETQELA-TYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIV
|. ||. ..|||.|||    |.||.|.| |...|...    . .||..|  .| .. |...|.|...||||||||.. ..|..|| ..  .  .|||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
||||||||||....||..|.....|| .||   |. || ||  ||||..||.||..||||.|
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1476-1733 6.7e-91 299.6 In-house 1-262 (263) alignment 
Range on Protein: 1476-1733
Range on HMM: 1-262/263.0
KFSQEYESIEPGQ-QFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMM
|...|.|..|  . . . .... ..||||||| |.  |||.||.|.  |.  ||||||||| .|..| ..|.||||||..|. |||||.|| |. .|||.
klkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TRLEERTRIKCDQYWPTR--GTETYGQIFVTITETQELA-TYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIV
|. ||. ..|||.|||    |.||.|.| |...|...    . .||..|  .| .. |...|.|...||||||||.. ..|..|| ..  .  .|||..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
||||||||||....||..|.....|| .||   |. || ||  ||||..||.||..||||.|
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1462-1733 7.1e-91 299.2 In-house 9-279 (288) alignment 
Range on Protein: 1462-1733
Range on HMM: 9-279/288.0
FaNHIERLKSNDNQKFSQEYESI-EPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFW
  ... . . .... ||.||.|. . ... . . ..| .|..|||| |. .||. ||.|  .| . |.|||||.| ||..|...|.||||||..|  |||
v.akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RMCWELKTATIVMMTRLEERTRIKCDQYWPTRGT-ETYGQIFVTITETQELATYSIRTFQLCRQgfNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCR
.. .| || ||||.| | |. . ||..|||. .. . ||.. ||..|..||  .  |.. | ..  ....||.|.|..||||||||.  ||.|..||   
elvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekk..kteleitqyqylaWpdhgvPeskapllellrqvk

ALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
   . ..||.|||||||||||| .|..| .......|. ||. | |. || ||. .|||. ||.||....|. |
vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0047943 (Phosphotyrosine protein) phosphatases II 1470-1733 4.3e-90 297.2 In-house 7-272 (273) alignment 
Range on Protein: 1470-1733
Range on HMM: 7-272/273.0
KSNDNQKFSQEYESIEPGQ-QFTWDNSNLEHNKSKNRYANVTAYDHSRVQLpaveGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKT
|....... .|.| . . . ..|.  ..|..||.|||| .. .|||||| |    |  |||||||.| |||.. ....||||||..|. |||||.|| ..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

ATIVMMTRLEERTRIKCDQYWPTRG---TETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPP-
 .|||.|.|.|. |.||.||||. |   ..|||...||...... ..| .||..| . |... |.......| |||||||......|.|.. .|      
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

-ESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
 ..|||.|||||||||||..|..| .|.....|. .|..  |  || || .||||..||.|...|.|| .
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1455-1752 4.8e-90 297.1 In-house 14-310 (319) alignment 
Range on Protein: 1455-1752
Range on HMM: 14-310/319.0
PPIPISEFANHIERLKSNDNQKFSQEYESI--EPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPL
|..|.      . .   .| .|.  |.  .   . .  . . .||..|| |||. |. |.|...|.|  ..|. .|||||| . .||.... |.|.||||
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

QETFVDFWRMCWELKTATIVMMTrleertRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQG-FNDRREIKQLQFTAWPDHGVPDHPAPF
..|  ||||| || ...|||..|      . || |||| .. .....  | ..  .| | | .| ..| ..|  .| |.|.|  |  |||.||||.|...
dntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdl

LQFLRRCRALTPPESG--PVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHL
...... | ||  | .  ...||||||||||| |||.| .|.|||.|| .|.|  |  || ||| .||   || ||. |.||  . | ..|   .. ..|
mrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayl

QKL
..|
eel
0045450 (Phosphotyrosine protein) phosphatases II 1454-1734 1.8e-89 295.8 In-house 6-305 (307) alignment 
Range on Protein: 1454-1734
Range on HMM: 6-305/307.0
HPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQF---TWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGV-VGSDYINANYC--------DGYRK
...|..  .  .. .|. ...... .|.|.. . . |   ... ..|..||.|||| .. .|||.||.|  ..|   .||||||.|         |||..
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

HNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTE-TYGQIFVTITETQELATYSIRTFQLCRQ-GFNDRREIKQLQFTAW
 ....||||||.||. |||||.||... .|||.|.|.|..|.||.||||. |.| |||...|| .....|. | .||. . .  | .  |.......|.|
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgw

PDHGVPDHPAPFLQFLRRCRALTP--PESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKI---IDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAII
||||||......|.|....|.     |..|||.|||||||||||..|... ||.....|..   .|..  |  ||.||  .||...||.|...|.|| . 
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1499-1735 2.2e-89 294.0 In-house 8-244 (250) alignment 
Range on Protein: 1499-1735
Range on HMM: 8-244/250.0
HNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIkCDQYWPTRGTETYG
.|| |||||.. |.|.||| |  ..|   |||||| . .||....|..|||||||.|..||||| .| |..||||.| |.|  .  . ||||. ..|.||
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyG

QIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPP-ESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEK
.. |.. ...| | | .|...| ..  .|.| ..||.|..||| |||..    |..|.. .|  .  ...||||.|||||||.|..|.||..|||.|.||
dvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek

IIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIIC
..|..  .  ||..|  .|....||.|.. .||.|. .
vvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1453-1757 4.4e-89 293.5 In-house 2-303 (315) alignment 
Range on Protein: 1453-1757
Range on HMM: 2-303/315.0
SHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPL
.| |||. ..  .. . |.. .. | |.||||  || .  | ..  .|| |||| |. |||.|||||| .|   .|||.|||. ||| |.. |.|.|||.
ahqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpn

QETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRgTETYGQIFVTITETQELATYSIRTFqlcRQGFND-RREIKQLQFTAWPDHGVPDHPAPF
 ..  ||||. .| . ..|||.| | |. . |...||| .   .||.| ||  . .    |..||.      |.|  ||. ||..|.||| ||| .  |.
vasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlhytswpdmgvpkytipl

LQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQK
... |. .     . |...||||||||||| .| .|..|.... |..||.|  .| .|..|  |||. .|| ||.||.||...|| | .  .    . . 
mnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqryds

LLITEP
||   |
llapsp
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1463-1733 4.1e-88 290.1 In-house 3-276 (281) alignment 
Range on Protein: 1463-1733
Range on HMM: 3-276/281.0
ANHIERLKSNDNQKFSQEYESIEP-GQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWR
 .|...|..|||. | .|||...  |.. |   |. ..|. |||| |..|||..||..   |    .||||||...||.....|.|||||. ...|.||.
rkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWq

MCWELKTATIVMMTRLEERTRIKCDQYWPTRG-TETYGQIFVTITETQELATYSIRTFQLcRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRA
| || |  .|||.||  |  ..|| .|||    . .||.. |. |...| |||  |.|.| ..  .. ||..||..|||||||||. .. .|.| .  . 
mvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlk

LTPPES-GPVIVHCSAGVGRTGCYIVIDSMLERMKHE-KIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
|| ...  |...||||||||||.|| .| .......| . .|.   |. || .||.||||  || |.. |.|.|.
ltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1492-1752 9e-88 289.4 In-house 17-274 (284) alignment 
Range on Protein: 1492-1752
Range on HMM: 17-274/284.0
WDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTrleertRIKCDQYWPT
   .||..|| |||. .. |.|...|.|  . |. .|||||| .  ||.... |.||||||..|  ||||| || ...|||..|      . || |||| 
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

RGTETYGQIFVTITETQELATYSIRTFQLCRQG-FNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESG--PVIVHCSAGVGRTGCYIVIDS
.. .....  | ..  .| . | .| ..| ..|  .| |.|.|  |  |||.||||.|......... | ||  | .  ...||||||||||| |||.| 
kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv

MLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKL
.|.|||.|| .|.|  |  || ||| .||   || ||. |.||  . | ..|   .. ..|..|
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleel
0040439 (Phosphotyrosine protein) phosphatases II 1781-2024 9.6e-88 289.2 In-house 3-246 (249) alignment 
Range on Protein: 1781-2024
Range on HMM: 3-246/249.0
FVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPH
. .|.||.||.||| ..||||..|||.|... | ..|||.|||.||||..  ..||.||| ... |||||||||...|..||||.|.|.|||||.||||.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

ERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIV
. |. |  ..|  . .. .. |..|....|.  ||.||||...|..|||..|||.| | ..||| .|.|  |. ...||. |||||||||.|.||.. ..
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

LERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
||....|. .|....|. |||||| .||...|| |.|.|.||.|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
DSPc_SM00195 1765-2024 3.9e-87 287.3 In-house 3-262 (263) alignment 
Range on Protein: 1765-2024
Range on HMM: 3-262/263.0
EVEFKKLSNVKMDSsKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLT
. ||.|| . . .. .. .|. . ||.|||  .||||...|| |..... |||||.||..|.|......|||.||| ..  |||||| ||....|.||||
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLKEMGREKCFQYWPHE--RSVRYQYYVVDPIAEYNMP-QYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDGPIT
. .| |.||| .||| |  .. ..... |  . . ... ...||....|   .  .|.|.|.|. .||..|||.| . ..... .|.|.|..   .||| 
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

VHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
|||||||||.|.|.|..|.|.... |  .|.|..|. ||.||| ||||..||.|.|.|.|||.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1765-2024 3.9e-87 287.3 In-house 3-262 (263) alignment 
Range on Protein: 1765-2024
Range on HMM: 3-262/263.0
EVEFKKLSNVKMDSsKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLT
. ||.|| . . .. .. .|. . ||.|||  .||||...|| |..... |||||.||..|.|......|||.||| ..  |||||| ||....|.||||
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

KLKEMGREKCFQYWPHE--RSVRYQYYVVDPIAEYNMP-QYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDGPIT
. .| |.||| .||| |  .. ..... |  . . ... ...||....|   .  .|.|.|.|. .||..|||.| . ..... .|.|.|..   .||| 
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..sgpiv

VHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
|||||||||.|.|.|..|.|.... |  .|.|..|. ||.||| ||||..||.|.|.|.|||.
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Ptp69D_pd Subfamily Ptp69D 1455-1752 5.2e-86 283.5 In-house 2-305 (307) alignment 
Range on Protein: 1455-1752
Range on HMM: 2-305/307.0
PPIPISEFANHIERLKSNDNQKFSQEYESIE-PGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQ
..|.| . .. ..  | . .. . .|||..|    . .  .|. . |. |||| ...|.|. ||.|. ..|   ||||||..  ||.... ..| |.|..
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQG-----FNDRREIKQLQFTAWPDHGVPDHP
.|  ||||| .| .  .|||.. |.| .| ||..|||   .  ||.| |.. ....   | ||.... ...      .|.|.. | ..|.|.|  ||...
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

APFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTH
   |..... | |   . .|..|||||||||.| .. .||.|...| |. .||.  |  || ||| .||  .||.|.. |.|. .  | |..  ..|. .
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

LQKL
...|
ierl
subfamily_PTPRB_pd Subfamily PTPRB 1763-2024 2e-85 281.3 In-house 26-285 (293) alignment 
Range on Protein: 1763-2024
Range on HMM: 26-285/293.0
GMEVEFKKLSNVKMDSSKfVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVM
..  |...|..|..| .. ..|.|..|. |||   ||||. ||| |..... .||||.||..|.||. .  .||.|||. .. .|||||.||..|.|.||
rfseeyeelkavgkdqav.kaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LTKLKEMGREKCFQYWPHE-RSVRYQYYVVDPIAEYNMPQYKLREFKVTDarDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIT
||.| | |..|| .|||.. ..| |    |. .|| .. .. .||.|..   . ..|.|||..|. ||. |||.. . ..||. .|....|.  ...||.
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPiv

VHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
|||||||||.|.||.|  .|.... | ..|.| .|  ||..|  .||||.|| | ... |..|
vhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
Y_phosphatase Protein-tyrosine phosphatase 1500-1731 3.9e-85 280.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 1500-1731
Range on HMM: 1-235/235.0
NKSKNRYANVTAYDHSRVQLpavEGVVG-SDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWP--TRGTET
||.|||| ....||..||.|   .|  | |||||||| .||.......||||||..|. |||||.|. |. .|||.|.|||. | ||.||||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGQIFVTIT-ETQ-ELATYSIRTFQLCRQGFND-RREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERM
||.|.|... ... . . | .|...|  .. .. .||.|||..|.|||||||..| ..|...|...  . ..||||.|||||||||||.....| .||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
..|. .|..  |  ||.||. |||...||||...||||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1500-1731 3.9e-85 280.4 In-house 1-235 (235) alignment 
Range on Protein: 1500-1731
Range on HMM: 1-235/235.0
NKSKNRYANVTAYDHSRVQLpavEGVVG-SDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWP--TRGTET
||.|||| ....||..||.|   .|  | |||||||| .||.......||||||..|. |||||.|. |. .|||.|.|||. | ||.||||  .....|
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGQIFVTIT-ETQ-ELATYSIRTFQLCRQGFND-RREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERM
||.|.|... ... . . | .|...|  .. .. .||.|||..|.|||||||..| ..|...|...  . ..||||.|||||||||||.....| .||..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
..|. .|..  |  ||.||. |||...||||...||||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0040439 (Phosphotyrosine protein) phosphatases II 1491-1733 2.8e-84 277.8 In-house 2-246 (249) alignment 
Range on Protein: 1491-1733
Range on HMM: 2-246/249.0
TWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWP
... ..|. ||.|||| .. .||||||.|  ..|. .||||||.| |||.  ....||||||.||. |||||.|||.  .|||.|.|.|. |.||.||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTP--PESGPVIVHCSAGVGRTGCYIVIDS
..|. .||...|| ....... | .||..| . .... |.....|.| |||||||......|.|....|      |..|||.|||||||||||..|... 
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

MLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
|||....|. .|..  |  || ||...||...||.|...|.|| .
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 1777-2027 7.6e-84 276.6 In-house 21-275 (278) alignment 
Range on Protein: 1777-2027
Range on HMM: 21-275/278.0
DSSKFVTANLPCNKHKNRLVHILPYESSRVYltpihgiegsDYVNASFIDGYryRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQ
. |.. .|....|..||| ..||||..|||.          ||.|||.||||  . ..||.||| .. ..||||||||...|..||||.|.|.|||||.|
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDA----RDGSSRTVRQFQFIDWPEQGVPKSG--EGFIDFIGQVHKTKE-----------QFGQDGP
||| . |..|  ..|  . |.... | || ..||.      |. ||.|...... ||. ||| .     |.... ....  .           .....||
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ITVHCSAGVGRSGVFITLSIVLERMqyEGVLDVFQTVRILRSQRPA-MVQTEDQYHFCYRAALEYLGSF
. |||||||||.|... . ..||..  ||..|....|. ||||||  .||...||.|.|...||.|  .
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPN9_pd Subfamily PTPN9 1759-2024 2.2e-83 274.7 In-house 13-290 (297) alignment 
Range on Protein: 1759-2024
Range on HMM: 13-290/297.0
ETISGMEVEFKKLSNVKMdSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNST
. ..|.  |.... | .. . .| ...|..| .|||   .| |...|| |. ... | |||.||.|.|||. . |.||.|||.. . .|||||.||..  
kgkrGlskeyaeirnepv.eGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevl

IVVMLTKLKEMGREKCFQYWP--HERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFG-
..|| |.. |.|| || ||||  .| | ..  . |  .   .. .|| | ......... ||.|  |||. ||. |||.|.. ..|.. .| ... ..  
vivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavk

----------QDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
          .. || ||||||.||.| |||| | |.|.. .|..||..||. ||.||  ..||..||.||| | ||| 
elgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0042113 (Phosphotyrosine protein) phosphatases II 1783-2024 5.1e-83 273.5 In-house 3-243 (245) alignment 
Range on Protein: 1783-2024
Range on HMM: 3-243/245.0
TANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHER
.|.||.||.||| ..||||...||.|.|. | ..|||.|||..||||.   .||.||| ..  |||||||||...|..||||.. |.||.||.||||.. 
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

SVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRSGVFITLSIVLE
|..|  ..|  . |.... |..|...||. .|. ||.|.......||..||| . | ..||.  |.|  .. ...||. |||||||||.|.||.. ..||
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaaylmle

RMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
....|. ......|. |||||| .|||..||.|.|.|.||.|
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1760-2023 6.8e-83 273.6 In-house 32-292 (319) alignment 
Range on Protein: 1760-2023
Range on HMM: 32-292/319.0
TISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTI
 .. .||||...... .. ..   |||. || |||...||... ..| | .. |.|.|||.||||..||. .  ||||||| ... .|||||.||.|.. 
dltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncst

VVMLTklkemgREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTD-ARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG
.|.||      ..|| |||| .  .... . |.  .  .  .| .|...... ..    | ..|| |  ||..|||...  .. .. .|.. ...  .  
ivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhra

PITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE--Y
.| |||||||||.||.|.| ..|.||. |  .||...|| || ||. .||   ||.|.| | ||   
nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
0045098 (Phosphotyrosine protein) phosphatases II 1478-1735 7e-83 273.5 In-house 11-274 (278) alignment 
Range on Protein: 1478-1735
Range on HMM: 11-274/278.0
SQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQlpavegvvgsDYINANYCDGYrkHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRL
.. .. . .|.  .. ..... |..|||| .. .||||||           |||||.| |||  .....||||||..|. |||||.|||.. .|||.|.|
lefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltel

EERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQ----GFNDRREIKQLQFTAWPDHGVPDHP--APFLQFLRRCRALTP--------
.|..|.||.|||| .|..|||...||......| .| .||. ..        .  |....|... |||||||..|  ..||..|...|.           
velgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

-----PESGPVIVHCSAGVGRTGCYIVIDSMLERMkhEKIIDIYGHVTCLRAQRNY-MVQTEDQYIFIHDAILEAIIC
     ...|||.|||||||||||...... |||..  |. .|..  |. || ||.. .||...||.|.....|| . .
slllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1762-2028 1.2e-82 272.5 In-house 22-287 (305) alignment 
Range on Protein: 1762-2028
Range on HMM: 22-287/305.0
SGMEVEFKKLSNVkmDSSKFVTANlPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVV
.|.|...|.| .   ..| .|. .   ||.||||..| ... .|. ||. .  . |||.|||..|||. . .||.||||...  .||||...|   . .|
kgleaqykslyee..eesidvgkk.eankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLTKLKEMGREKCFQYWPHERSV--RYQYYVVDPIAEYNMPQYKLREFKVTD-ARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDG
|||||.| |..|| ||||.. .   ... ..|    | ....|  |..|..    |  |||| |.|. |||..|||..   ....| .|.|.... ... 
mltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk.dkgv

PITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFD
|..|||||||||.||||...| |||.. |.|.|||. .. |||.|. |||| ||| |.. |  |.. ..|
pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd
subfamily_PTPRG_pd Subfamily PTPRG 1762-2026 1.4e-82 272.7 In-house 19-289 (563) alignment 
Range on Protein: 1762-2026
Range on HMM: 19-289/563.0
SGMEVEFKKLSNV-KMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGS-DYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTI
 |.. ||..| .  . .. .  ... |.||.||| . |..|..||| |.|. |.... ||.||..||||.   |.||.|||..| ..|||||.||.|..|
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

VVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTD-----ARD-GSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQ
.||.|.|.| ||.||..|||.. |..|.   |  |.|  .  |  |.... .      ..  . ..|||... .||..|||..    . |. .  .....
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

fgQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS
  . |||.|||||||||.|..| |. .|...| | . .||.... .|.||. .||||.|| | . | || . |
..eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1784-2031 1.6e-82 271.5 In-house 4-249 (250) alignment 
Range on Protein: 1784-2031
Range on HMM: 4-249/250.0
ANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREkCFQYWPHERS
|. | ||.|||  .|....|||| | . .| . |||.||||..||. |.|.||.|||.|.. ||||||..|..|. .||||.|||.... . |||| |..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

VRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRSGVFITLSIVLER
 .|    |..  . ..  |. |..|.. |.  ..|.|||..|. ||..|||.  .  .... .|.....|  ...|. |.||||||||| ||... ||||
ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGvgrsGafiaidavler

MQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNYT
.. | |.|||. ...|| .|| .|....|| |.|...|..| |...|.
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedya
subfamily_Ptp69D_pd Subfamily Ptp69D 1758-2024 2.2e-82 271.7 In-house 18-286 (307) alignment 
Range on Protein: 1758-2024
Range on HMM: 18-286/307.0
GETISGMEVEFKKLSNVKMDSSkFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNS
..|  |.. |..|| . ..| |  ....   |. |||  .| .... || |..| | | |||.||||| ||. .  .||||.||.  ..|||||..| ..
rdtdfglakeyekLeareidks.tkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqev

TIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGS-----SRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKE
|..|||..|.|. |.|| .||| |  |.|.  .|... | ....|  ||..|.   . |     || | |...  |..  ||.. .| ...| ||.. ..
tlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyk

QFgqDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
.    .||.|||||||||||.|..|...|.... |  .|.|.||. |||||. .||  .|| |.||| |.| 
ln..rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
0042113 (Phosphotyrosine protein) phosphatases II 1494-1731 5.9e-82 270.0 In-house 3-241 (245) alignment 
Range on Protein: 1494-1731
Range on HMM: 3-241/245.0
NSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRG
 ..|..||.|||| .. .|||.||.|. ..|  .||||||.| ||||  . . ||||||.||. |||||.|||.  ||||.|..||. |.||.||||...
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

TETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTP-PESGPVIVHCSAGVGRTGCYIVIDSMLER
. |||...|| .... |..| .||... . | .  ||. ..... ||||||||... .|.||...|     ...|||.|||||||||||..|... |||.
sltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleq

MKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
...|. ....  |  || ||  .|||..||.|...|.||
lekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN9_pd Subfamily PTPN9 1467-1731 2e-81 268.3 In-house 8-288 (297) alignment 
Range on Protein: 1467-1731
Range on HMM: 8-288/297.0
ERLKSNDNQKFSQEYESIEPG-QQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWE
. .|.....  |.||. |     . | ..|.|  | .||||..|  ||..||.|. |..   |||||||..|||....|..||||||..|. ||||| ||
ayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWe

LKTATIVMMTRLEERTRIKCDQYWP--TRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRA---
 .. .|||.||..|| |.|| ||||  .  .. .|.. |.  |..|   | .|.... .   .. |..   ||..|||.|||.  | .|..|.  |    
qevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqa

-----LT-----PPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
     |.     .|.  |..||||||.|||| .| .|  |.|....  .|.   |  ||.|| ...||..|| | . |.||
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1765-2022 5.3e-81 267.2 In-house 1-253 (284) alignment 
Range on Protein: 1765-2022
Range on HMM: 1-253/284.0
EVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLT
||||...... .. ..   |||. || |||..|||... ..| | .. |.|.|||.||||| ||. .  |||.||| ... .|||||.||.|.. .|.||
evefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt

klkemgREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTD-ARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVH
      ..|| |||| .  .... . |.  .  .  .| .|...... ..    |..||| |  ||..|||...  .. .. .|.. ...  .  .| ||
......kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

CSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE
|||||||.||.|.| ..|.||. |  .||...|| || ||. .||   ||.|.| | ||
csagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN6_pd Subfamily PTPN6 1470-1731 1.3e-79 262.4 In-house 21-295 (306) alignment 
Range on Protein: 1470-1731
Range on HMM: 21-295/306.0
KSNDNQKFSQEYESI---EPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPaVEGVVGSDYINANYCDGY--RKHNAYVATQGPLQETFVDFWRMCW
.| ... |..|.|..   |  .... ....  .||.|||| |.  .||.|| |   ..|.||||||||| ..    ....|.|||| |..|  ||||| |
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

ELKTATIVMMTRLEERTRIKCDQYWPTRGT-ETYGQIFVTITETQELATYSIRTFQLCR-QGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRA--
. ..  |||.|.  ||.. || .|||.  . |.||.| || .. ..||.| .|...... .  .. ||. |..|..||||||| .|  .|.||.  ..  
qensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkq

--LTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKI---IDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
  |.  |.||..||||||.|||| .|||| .|. ......   |||.  |  .|.||. .||||.|| |.. || .
eeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_PTPRK_pd Subfamily PTPRK 1784-2022 3.8e-79 260.8 In-house 38-275 (314) alignment 
Range on Protein: 1784-2022
Range on HMM: 38-275/314.0
ANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERS
|.   |..|||  .||.|. ||| |..|.|   |||.||..||.|.  .|.|..|||.|.  .||||.....|.. .||||.|.| || || .||| . .
akkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedte

VrYQYYVVDPIAEYNMPQYKLREFKVTD-AR-DGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQfgQDGPITVHCSAGVGRSGVFITLSIVL
| |.   |  .      ..  | |.|.  ||     |.||||||. ||. .||.| .|..... .|.|..|.  ..|.| |||||| ||.|.||...|||
v.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidivl

ERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE
. .. |||.|||..|. |||... ||.||.||.|.| ..||
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
Y_phosphatase Protein-tyrosine phosphatase 1789-2022 8.1e-79 259.7 Pfam-A 1-235 (235) alignment 
Range on Protein: 1789-2022
Range on HMM: 1-235/235.0
NKHKNRLVHILPYESSRVYLtpiHGIEG-SDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWP--HERSVR
||.|||  .||||...|| |   .| || |||.||....||.  ...||.|||...  ||||||.|.......||||.|.|.||||| ||||   |.|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYYVVDPI-AEY-NMPQYKLREFKVTDARDGS-SRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQDGPITVHCSAGVGRSGVFITLSIVLE
|. . |     |  .. .| ||......  . | .|.|.|... .||..|||.| ....|.| .|.|.|    ..||..|||||||||.|.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE
... |. .||.|.|. ||.||| |||...|| |.|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1789-2022 8.1e-79 259.7 In-house 1-235 (235) alignment 
Range on Protein: 1789-2022
Range on HMM: 1-235/235.0
NKHKNRLVHILPYESSRVYLtpiHGIEG-SDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWP--HERSVR
||.|||  .||||...|| |   .| || |||.||....||.  ...||.|||...  ||||||.|.......||||.|.|.||||| ||||   |.|..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YQYYVVDPI-AEY-NMPQYKLREFKVTDARDGS-SRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKeqFGQDGPITVHCSAGVGRSGVFITLSIVLE
|. . |     |  .. .| ||......  . | .|.|.|... .||..|||.| ....|.| .|.|.|    ..||..|||||||||.|.|..|.|.||
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldille

RMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE
... |. .||.|.|. ||.||| |||...|| |.|.| ||
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1760-2021 1.1e-77 256.0 In-house 19-276 (288) alignment 
Range on Protein: 1760-2021
Range on HMM: 19-276/288.0
TISGMEVEFKKLSNVKMDSSKfVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTI
. .|.. |...|.... ..|.  ...|. |..|||   ||||.  || |.  .  .|.||.|||.|||.. . .|||.|||..|. .|||.. .|.... 
nrtgfseeynsLaalektksv.tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

VVMLTKLKEMGREKCFQYWPHERS-VRYQYYVVDPIAEYNMPQYKLREFKVTdaRDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFgqDG
.||||.| | |..|| .|||..   ..|    |  . . .. .. ||.. .   .... ... |.|.  ||..|||.| . ..... ||. ....    |
ivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..tg

PITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAAL
||.|||||||||.|.||.|  ...... | ..||. ||  || ||. .|||. || |.|.. |
piivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN6_pd Subfamily PTPN6 1742-2025 2.4e-77 254.9 In-house 6-298 (306) alignment 
Range on Protein: 1742-2025
Range on HMM: 6-298/306.0
ARNLHTHLQKLLITEPGETISGMEVEFKKLSNVK-MDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTpIHGIEGSDYVNASFIDGYR--YRSAYIAAQ
|.... . ..|  .|   . .|.| ||..|.. . ..  .   .. | ||.|||   |||.. .|| |.  ... ||||.||..|..     . .|||.|
akeieqrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatq

GPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVR-YQYYVVDPIAEYNMPQYKLREFKVT-DARDGSSRTVRQFQFIDWPEQGVPKS
| ...  .|||||.|. ||...||.||  | |.||| .|||.| . . |  . |  ..| .. .|.|||..|.   .....|.|.|..| .||..||||.
gclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkd

GEGFIDFIGQVHKTKEQFG--QDGPITVHCSAGVGRSGVFITLSIVLERMQYEGV---LDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLG
 . ..||. .|.. .|..   . ||| ||||||.|| | || . |.|. ....|.   .|. ..|...|.||  .||||.||.| |.|  .|. 
pgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1456-1770 3.8e-77 254.2 In-house 2-314 (315) alignment 
Range on Protein: 1456-1770
Range on HMM: 2-314/315.0
PIPISEFANHIErlKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQET
|||...|   ..  |      ||.|.  .   . .    .  . | .|||| |.  .|..||.|  ..    |||||| |  .. . .||.|.||||. .
pipvaqfpafvn..knrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkas

FVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGT--ETYGQIFVTITETQELATYSIRTFqLCRQGfNDRREIKQLQFTAWPDHGVPDHPAPFLQ
  ||||| .. |..||||.| ..|  .||| |||| | .    .|.| |.. ...  .   .| .   |.. .. | . | ||| |||.||. . . .|.
vddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllk

FLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLL
...  .|   ..  ...|||||||||||  | ||......|... .|..  |. |||.| |.||||..| ||.||.|| .    | ..  ..  ||| | 
likevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlh

ITEPGETISGMEVEFKK
 .  |.  | |  ||..
tsvdgsgrskmtkefet
subfamily_PTPN12_pd Subfamily PTPN12 1482-1733 2.5e-76 251.3 In-house 22-277 (290) alignment 
Range on Protein: 1482-1733
Range on HMM: 22-277/290.0
ESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERT
|     .... .... |.|. |||| ..  ||.|||.|   |.. ||||||||.  |  .. .|.|.|||| .|  ||||| || ..  .||. |. |  
ekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelg

RIKCDQYWPTRGTET--YGQIFVTITETQELA-TYSIRTFQLCRQgfNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVG
..||..||| .| |.  .|.. || .| . .   . |||... .|  ...|...|...|||||||||  . . |....  | |   |. |..||||||||
kkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvG

RTGCYIVIDSMLERMKHEKI---IDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
|||  |.|| . | .|.|||   .|..  |. || ||. .|||..|| ... |..| .
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1456-1778 3.6e-76 251.3 In-house 1-321 (515) alignment 
Range on Protein: 1456-1778
Range on HMM: 1-321/515.0
PIPISEFANHIErlKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQET
|.|...|   ..  |..    ||.|.  .   . .    .. | | .|||| |.  || .||.|  ..    |||.|| |  ..   .||.|.|||.. .
plplaqfPafvn..knrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkas

FVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTE--TYGQIFVTITETQELATYSIRTFQLCRQgfNDRREIKQLQFTAWPDHGVPDHPAPFLQ
  ||||. .. ...||.|.|.|.|  .||| .||| . ..   .|.| | .  ..  .   .|.... ..  .| | . | .|| |||.||| |   .|.
vddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkg..ddsrtvtqfhfteWPdkGvpkhtssllk

FLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLL
...  .| .   . |.|.|||||||||| .| |||.. ..|  ...|..  || .|..| |.|||..|| ||..|.|| .    | .|   .  ||| | 
likevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlh

ITEPGETISGMEVEFKKLSNVKMDS
 .  |.  | |  ||. | ..  | 
ssgdgrgrskmtkefqtlkslcpdp
0037934 (Phosphotyrosine protein) phosphatases II 1492-1731 6.2e-76 250.4 In-house 2-240 (243) alignment 
Range on Protein: 1492-1731
Range on HMM: 2-240/243.0
WDNSNLEHNKSKNRYANVTAYDHSRVQLpavEGvvgSDYINANYCDGYRKhnaYVATQGPLQETFVD----FWRMCWELKTATIVMMTRLEERTRIKCDQ
.  ..|. |.||||| .. .|||||| |   ||   |||||||.......   . ||||||.||. |    ||||.|||.. .|||.|.|.|..|.||.|
fsiallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPtrGTETYGQIFVTITETQELATYSIRTFQLCRQG-FNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAL--------TPPESGPVIVHCSAGVG
|||  |..|||...||......|. | .||..|.. .  .  |.. ......||||||||.|...|.||. .|.         . ...|||.||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGCYIVIDSMLERMkheKiIDIYGHVTCLRAQRNY-MVQTEDQYIFIHDAILE
|||..|... ||...   . .|..  |  ||.||.. .|||..||.|...|.||
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 1781-2024 2.6e-75 248.4 In-house 2-242 (243) alignment 
Range on Protein: 1781-2024
Range on HMM: 2-242/243.0
FVTANLPCNKHKNRLVHILPYESSRVYLtpihgiEGSDYVNASFIDGYRYrsaYIAAQGPVQDAAED----FWRMLWEHNSTIVVMLTKLKEMGREKCFQ
| .|.||.|..|||  .||||. |||.|      |||||.||..|.....   .|| ||| ..  ||    |||||||...|..||||.|.|.|||||.|
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPheRSVRYQYYVVDPIAEYNMPQYKLREFKVTDAR-DGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQ------FGQDGPITVHCSAGVG
|||   .|.|  ..|  . |.....|..|.....    |. .|.|...... ||..||| | | ..||. .|..  |.        ..||. ||||||||
ywp..gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RSGVFITLSIVLERMqyeGvLDVFQTVRILRSQRPA-MVQTEDQYHFCYRAALEYL
|.|..|.. ..|...   | .|....|. ||.|||  .|||..||.|.|.|.||.|
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 1775-2024 3.4e-74 244.3 In-house 25-277 (290) alignment 
Range on Protein: 1775-2024
Range on HMM: 25-277/290.0
KMDS-SKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREK
|...  .  ... . |..|||   ||||. ||| |. |.. |||||.||.|| |   . .|||||||. .. .|||||.||.| .||||. .. |.|. |
kaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkk

CFQYWPHE--RSVRYQYYVVDPIAEYNMP-QYKLREFKVTDArdGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGR
| .|||.|  ...... . |. ..| ..  .. .| .||.    . ||.|.||.. .||..|||.| .  ...| .|....|   .| |. |||||||||
CerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGr

SGVFITLSIVLERMQYEGV---LDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
 |. |.. .| | .. | .   ||||. |. || ||.|.|||..||.. |.| .|..
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1759-2024 2.2e-73 241.8 In-house 12-276 (281) alignment 
Range on Protein: 1759-2024
Range on HMM: 12-276/281.0
ETISGMEVEFKKLSNVKMDSSKfVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNST
.  .|.  |..||... .|..  . .. . |..||| . |  |. .|| .|| .  . .||.||.|..||.   .|||.|||| .. ..||.|.||.. .
ndnaGfieeyeklaaigvdnta.taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvs

IVVMLTKLKEMGREKCFQYWPHER-SVRYQYYVVDPIAEYNMPQYKLREFKVtDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQd
..||.|.  | |. || .||| .. ...|  ..|  .|| . ..|  |.||. ....| .|.|.|.... ||..|||.. . ...|  .|.|..|.  . 
aivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.

GPITVHCSAGVGRSGVFITLSIVLERMQYE-GVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
 |. .||||||||.|..|.|  ...... |   ||| ..|. || .|  ||||  ||.| |.| |..|
aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1762-2030 2.4e-73 241.5 In-house 20-289 (290) alignment 
Range on Protein: 1762-2030
Range on HMM: 20-289/290.0
SGMEVEFKKLSNVKMDSSKFVtANLPCNKHKNRLVHILPYESSRVYLTPIHGIEG--SDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTI
.|.. .||.| . . . .  | .. . ||..||  .|..|.  |. | || | .    .|.||..|.||. . .|||.||||.. . |||...|....||
egfrnqfkmldsgesehtvtv.gltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvti

VVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARD-GSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqDG
.||||. .|.|..|| ||||.. . .|... .  . | .. .|  |...|.. .  |....| |.|.  |...|  .  .. .  | .. ||. . | ..
ivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.nt

PITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNY
.| ||||..||||.||... . ..... ||| |||| .. .|.|.| .|||..||.. ..  |.|| ||..|
sivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_PTPN3_pd Subfamily PTPN3 1490-1732 1.4e-72 238.9 In-house 31-274 (280) alignment 
Range on Protein: 1490-1732
Range on HMM: 31-274/280.0
FTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEgvVgsDYINANYCD----GYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKC
 . ..... .| ||||| ....||. ||.| . |  .  ||||||| .    .    | |.||||||..|  |||.| || |. .|||.| | || |.||
laisaarkpenlsknryrdilpydatrvklkese..t..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkC

DQYWPTRG-TETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYI
 ||||. . . .||.. |......|  .| .| . |...  ...|.| |||..|||||||||..| ||.|..| |.|   .. ||.||||||.|||| .|
hqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvli

VIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEA
...  |  . ... . .   |  .| ||  .|||..|| |. .|||..
lletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1460-1741 1.5e-72 239.5 In-house 5-287 (439) alignment 
Range on Protein: 1460-1741
Range on HMM: 5-287/439.0
SEFANHIERLKSNDNQKFSQEYESIEPGQ---QFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETF
.|| .|.|.|. |... |....|.|.  .   .        |....|||| .|.|.||.|| |  . ||  | |||||| .|| . . |.||||| .|| 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

VDFWRMCWELKTATIVMMTRLEERTRikcdqYWPTRGTETYGQIFVTITETQELATYSIRTFQLC--RQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQF
 ||||. .| ||.||||.| | |  .     |||. .   ||.| | .    ||  | || |..   |.  .  | . |....||||. || . .  |.|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

LRRCRA-LTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVP
||   .     | |||.|||||||||||  | .|  ||..| |. .|| | |. || ||. |||.  ||.||..|.|| |. | . | 
lrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1455-1743 4.5e-71 234.4 In-house 8-294 (297) alignment 
Range on Protein: 1455-1743
Range on HMM: 8-294/297.0
PPIPISEFANHIERlkSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKhnAYVATQGPLQE
 |||.|.||  ...  . . . ||.|.  .   . ..   ..   | .|.||.|.  || |||.|  |.    |||.|| .  |...   ...|| | ..
rpiplsdfatlvqk..nrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TFVDFWRMCWELKTATIVMMTRLEERTRiKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPD--HPAPFL
|  |||.| .. ...||||.. ..||.. || .||. .|. |.|.. |... ..|   .. |.... ..    || .|| ||. |||. |.   . . .|
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassll

QFLRRCRALTPP-ESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPAR
...   |      ..||..|||.||||||| .. |||.. ..|.|| .||.| |. || .| |.|||..|| |.. |.|||...  |...| 
klisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_PTPN13_pd Subfamily PTPN13 1473-1733 1.1e-70 233.0 In-house 9-269 (273) alignment 
Range on Protein: 1473-1733
Range on HMM: 9-269/273.0
DNQKFSQEYESIEPGQ-QFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGvvgsdYINANYCDGYRK--HNAYVATQGPLQETFVDFWRMCWELKTA
|.|. ..|.. ..  . . | . .. ..||.|||| ||  ||..||.| .  |     ||||..        .  |.|.|||| ||  |||.| || |. 
dqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkae

TIVMMTRLEERTRIKCDQYWPTRGT---ETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPpES
 |.|.|   |. ..||..||| .       .... |.  ..|.| ....|....  .  .. ||. .|.|..||||||| ..|..|||... | |   ..
viamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.da

GPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
||..||||||.||.| .|.|| .|. ....| .|.   | .|| ||. .|||.|||||.. ||||..
gPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1762-2032 1.5e-70 232.5 In-house 20-286 (287) alignment 
Range on Protein: 1762-2032
Range on HMM: 20-286/287.0
SGMEVEFKKLSNVKMDSsKFVTANL-PCNKHKNRLVHILPYESSRVYLTpihgIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIV
 | .  |. | .|. .  . || |. . ||.|||| .||...  || |      |  ||.||.|||||. . |.|.|..|. ..| .||......| |..
egfknqftvleqvtqre.devthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtai

VMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDAR-DGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqDGP
|||...||  .|.|.||||.|.|| .  | .  . |  . .|  |...|.    .|. ..|.|.|. .|...|  .. .  .  | .  ||. . | ...
vmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg.nts

ITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNYTN
| ||||..||||..|.   . ... . |||.|||| ..  | |.| .||| .||.| . . |||| ||. |..
ivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysd
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1499-1731 1.8e-70 231.8 In-house 2-237 (237) alignment 
Range on Protein: 1499-1731
Range on HMM: 2-237/237.0
HNKSKNRYANVTAYDHSRVQLPAVEGVvgSDYINANYCDGYRK-HNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWP-TRGTET
.|| ||||.|..||||||| |    .   ||||||.| .|.    . |.|.||||. .  |||.| |. | . |||.| | |. ..|| .||| |   ..
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGQIFVTITETQELATYSIRTFQLCRQG-FNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTP--PESGPVIVHCSAGVGRTGCYIVIDSMLERM
||.. |...  .|.. |..|.. | ...  .. | |.| |||.|||.|||.. | .|.| ..    .|  .|||| |.|||||||||| ..|||.|| . 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

KHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
| .|..||| .| ..  .| |..||.|||.|||..|||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1457-1733 2.1e-70 231.9 In-house 2-283 (290) alignment 
Range on Protein: 1457-1733
Range on HMM: 2-283/290.0
IPISEFANHIERLKSNDNQKFSQEYESIEPGQ-QFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGV--VGSDYINANYCDGYRKHNAYVATQGPLQ
||...|.....  ... |..| ....... |. ..|    . . || .||.||.  ||  |. |  . |      .|||| | .||.....|.|||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGF-NDRREIKQLQFTAWPDHG-VPDHPAPF
.| ||||.. |. |.. |||.|   |  . || ||||...|..||.. ..... ..| .| .|....  .   .......|.|.|.|...| |... .  
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
|.. .. .    .  ....||||..|||.. .....  ....| |  ||..  .  .| |.  .|||..|| .|.. .|...
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1479-1730 7.3e-70 230.2 In-house 9-265 (274) alignment 
Range on Protein: 1479-1730
Range on HMM: 9-265/274.0
QEYESIePgQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVG-SDYINANYCDGYRK-HNAYVATQGPLQETFVDFWRMCWELKTATIVMMTR
.|. .. |   |. .. ..  ...|||| ..   ..||| | . ..    |.||||||  ||.. ..|||||||||..|  ||||| .. ..  |||.|.
keflel.P.lnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk

LEERTRIKCDQYWPTRG----TETYGQIFVTITETQELATYSIRTFQLCRQgfNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRC---RALTPPESGPV
|.|. . || .|.|..     .|.||.. ...... |   ||.|.. |  .  ...|..|   .|.|||| .||.. ..|....     |  .  . .||
lkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyl..erersvkhywytdWPdhksPddantlldlvleveesreeenaklapv

IVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAIL
.||||||.|||||.| |.  . ....|...|. . |. || .|  ||||..|| .|| |. 
vvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1788-2024 1.1e-69 229.9 In-house 42-276 (515) alignment 
Range on Protein: 1788-2024
Range on HMM: 42-276/515.0
CNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPH--ERSVR
 | .|||   ||||.|.|| |  |.    |||.|||.| ..    ||||.||| . . .||||.....| | ..|.|||||  . || .|||.    ||.
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YQYYVVDPIAEYNMPQYKLREFKVTDARDgsSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqdGPITVHCSAGVGRSGVFITLSIVLERMQ
. .. |. ..     .   |...|.   |  |||| ||.| .||..||||    .. .| .|   ..|.    |. .|||||||| ||.|..  |. ...
fGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsvvahak

YEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
   ..|||..|...| .|| .|||..|| | | | ||.|
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1458-1765 3.2e-69 228.5 In-house 6-320 (325) alignment 
Range on Protein: 1458-1765
Range on HMM: 6-320/325.0
PISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFV
 . .. .|.|. |..|.. |..|.. . . .  .   . . .||.|||. || |.|.||| | . .    ||||||.|   ..| . ..|.| || .|  
avvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin

DFWRMCWELKTATIVMMTRLEErTRIKCDQYWPTR--GTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFL
|.||.  . ... .|..  |..    .| .||| .   . |.| . | .   .|.. |  | ... .    . | .||.|. .|.| ||. .|| .. .|
dlWrlvldWrcsvvvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisil

RRCRAL----T--PPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHL
.   |.    |     |.|..||||||||||| .| . |.|... .|  .||.| |  ||..|  ||.| ||||.|..|. ||...| |.||  .....|
qlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeakl

QKLLITEPGETISGME
  |   .|      .|
sslqernpltqklnie
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1499-1732 1.6e-67 222.2 In-house 6-239 (239) alignment 
Range on Protein: 1499-1732
Range on HMM: 6-239/239.0
HNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYR-KHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTrGTETY
 ||.||||||. .|||||| |  .     ||||||.|   |    .||.|||| .. .  ||||| |. . . |||.| | |  . || ||||   |  |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.stsky

GQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEK
 .. ||. .|. .| | |||| . . |  . | . | .|| |||.|||.. .  | . |.    . | . | ..||||||||||...|||.|| . |..|
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

IIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEA
 .||. .| ..| .| .|||| .||.||| |.|||
tvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1457-1740 2.3e-67 222.0 In-house 2-285 (287) alignment 
Range on Protein: 1457-1740
Range on HMM: 2-285/287.0
IPISEFANHIERLKSNDNQKFSQEYESIEP-GQQFTWDNSNL-EHNKSKNRYANVTAYDHSRVQLPavegVVGSDYINANYCDGYRKHNAYVATQGPLQE
||...|.. ... . . |. |.. .  .|  .|.      |. ..|| |||....  .|  || |         ||||| . |||....|......|. .
ipvekfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn

TFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQG-FNDRREIKQLQFTAWPDHG-VPDHPAPFL
| ..||.. .. .  .|||.....| .. .| ||||.  . ..|.  ..... .  | | .|.... ...  .|....|| |.|.|...| |... . .|
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill

QFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEV
.. .. ..   .  ....||||..|||.. .. ..  ... | | .||..  .   | |.  .||| .||.|| |..|| . .. | .
vieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1499-1731 5.8e-67 220.3 In-house 7-239 (239) alignment 
Range on Protein: 1499-1731
Range on HMM: 7-239/239.0
HNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYR-KHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTrGTETY
 ||.||||||. .|||||| |  .     ||||||.|   |    .||.|||| .. .  ||||| |. . . |||.| | |  . || ||||   |  |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd.stsky

GQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEK
 .. ||. .|. .| | |||| . . |  . | . | .|| |||.|||.. .  | . |.    . | . | ..||||||||||...|||.|| . |..|
cnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqk

IIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
 .||. .| ..| .| .|||| .||.||| |.||
tvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN3_pd Subfamily PTPN3 1767-2019 5.9e-67 220.5 In-house 20-270 (280) alignment 
Range on Protein: 1767-2019
Range on HMM: 20-270/280.0
EFKKLSNvKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHgieGsDYVNASFI----DGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVM
.|..|   |  . .  .|..| | .|||   ||||.. || |.  .     ||.||...    ..      |||.|||....|.|||.|.||..|...||
qfeqlyr.kkpglaisaarkpenlsknryrdilpydatrvklkese...t.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

LTKLKEMGREKCFQYWPHE-RSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPIT
|| | | || || ||||..  ...|  . |    | .  .| |||. ..|..   .|.. |.|...||..|||.. . |..|. .|.|...  |.. |. 
lttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrs..gkeePvv

VHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRA
||||||.||.||.|.| . |  .. .  . . . || .| || ..|||..||.|   |
vhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCea
subfamily_PTPN13_pd Subfamily PTPN13 1766-2026 1.7e-66 219.3 In-house 15-271 (273) alignment 
Range on Protein: 1766-2026
Range on HMM: 15-271/273.0
VEFKKLSNVKMDSSKfVTANLPCNKHKNRLVHILPYESSRVYLTPIHGiegsdYVNASFIDGY--RYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVML
 |||.| ..|   .   ...   ||.|||  ..|||. .|| |    |     |.|||.|       .  |||.|||. ....|||.|.|| ......|.
eefkelrelkpldtc.evgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TKLKEMGREKCFQYWPHERSVRYQYY---VVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPI
|. || |. || .|||.... . . .    |. .   .. ....|...|.| . | || | ...|..||. |||.| . .. |. .| . ..   . |||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...dagPi

TVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS
 ||||||.||||..||. .||. .. .  .|| ..|| || || ..|||.||| |.|.|.|| |.|
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1783-2025 4.7e-66 217.7 In-house 22-269 (274) alignment 
Range on Protein: 1783-2025
Range on HMM: 22-269/274.0
TANLPCNKHKNRLVHILPYESSRVYLTPIHGIEG-SDYVNASFIDGYRYRS-AYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPH
  ... ...|||   ||| | ||| |.. .. .  |.|.|| .| ||...| ||.|.|||.. . .|||||.........||||||||. ..|| .|.|.
eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

ERSV----RYQYYVVDPIAEYNMPQYKLREFKVTDARDgsSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD-GPITVHCSAGVGRSGVFI
....    ||.   .      .  .|..|.. .  . .  .|.|  . . |||.. .|.. . ..|.. .|....|.  .  .|. ||||||.|| |.||
aedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi

TLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLG
. || . ... |.|.||...|  || .|  ||||..||.. .||  .|| 
aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1783-2024 4.9e-66 217.8 In-house 43-279 (315) alignment 
Range on Protein: 1783-2024
Range on HMM: 43-279/315.0
TANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHEr
.|.   ||.||| ..|..|. |||.|  .   ..||||||.||||| ..  |||||||   . .||||...|.. . .||||.| |  ..|. .||| . 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

SVRYQYYVVDPIAEYNMPQYKLREFKVTDarDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqdGPITVHCSAGVGRSGVFITLSIVLE
 | |  . |  . |    .|  | . |.   .   |.| |...  ||. ||||.   ....| .|.. ...    |.| |||||||||.| ||||. ||.
kviyGkitvtrkseevnteytvrtlsvvf..gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavld

RMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
... | ..||.. .. .|..|  |||. .||.| | | || .
qaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_PTPN14_pd Subfamily PTPN14 1766-2024 1.1e-65 216.5 In-house 27-296 (300) alignment 
Range on Protein: 1766-2024
Range on HMM: 27-296/300.0
VEFKKLSNVKMdSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIeGSDYVNASFIDGY--RYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVML
.|. .... ..  ... ||.|| |..|||  ..|||| .|| |.| .    ..|.||| |       .  ||.||||.. . .|||.|.||.. ...|||
teyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TKLKEMGREKCFQYWPHE----RSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ---
|. .| |.||.|.|.|..    ..|... . |      . ...  . .|.     .  |||  .|..|||..|||.  .||.... .|.  .... .   
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

----DGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
    . |. |||||||||.|| |.  .... .. . ..|. .....|| ||  .|||  ||.| |.. ..||
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1784-2028 1.9e-65 215.9 In-house 46-288 (297) alignment 
Range on Protein: 1784-2028
Range on HMM: 46-288/297.0
ANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYrsAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGReKCFQYWPHERS
|.   | .|.|   ||||.|||| |  .     ||||||||. |...   .|. | | ... .|||.|..... ...|||....|  . || .||. . .
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgv

VRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPK--SGEGFIDFIGQVHKTKEQFGQDgPITVHCSAGVGRSGVFITLSIVL
. . . .|   .  .   .  ||..||  .  . | |.|.||..||.. |..  | . ....| .|.|. .|  .  |. |||.||||| ||..|.  |.
ttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvv

ERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFD
 ... |  .|.|..|. || .|| .|||..||.| | | ||.| | |
aeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1779-2024 2.9e-65 215.2 In-house 34-277 (315) alignment 
Range on Protein: 1779-2024
Range on HMM: 34-277/315.0
SKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYW
..  .|  . | .|||   |||..|.|| |  |  .  |||.|||.| ..    ||||.||| . . .|||||..... | .||.||..|  . || |||
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PH--ERSVRYQYYVVDPIAEYNMPQYKLREFkVTDaRDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQfgQDGPITVHCSAGVGRSGVFIT
|.    ||..  . |. .      .   |.. ||  .  .|||| |||| .||..||.|    .. .| .|   ...  .. .. |||||||||.||.|.
PdrkadsvefGsikvellsleadtdgvarkl.vtr.kseesrtvtqfqftewPdkGvdkqtssllklikevkadngk..kefsllvhcsaGvGrtGvvis

LSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
.  |..... . ..|||..|..||..|| .||||..| | | | ||.|
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_CG7180_pd Subfamily CG7180 1498-1738 1.5e-63 209.2 In-house 40-295 (296) alignment 
Range on Protein: 1498-1738
Range on HMM: 40-295/296.0
EHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRiKCDQYWPTRGTETY
..|. |||. .|  ||. || |. ..|   |||||| | |.. |...|. |..| .||  .|||. .. .. ..|..|.  . .. .. .||| .. | |
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqy

GQIFVTITETQELATYSIRTFQLCRQ----------GFNDRREIKQLQFTAWPD-HGVPDHPAPFLQFLRRCRALTP-----PESGPVIVHCSAGVGRTG
|.||| |.|....|   ||||.| ..             . | .|..|.| |.  . ||   . .....|| | .       || |||.|..| |..|.|
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsG

CYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVT
 |. ||  || ...|. .|... |  || .|. .|.. ..| .| | .|||..|...
vylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1469-1746 2.7e-63 208.5 In-house 3-279 (283) alignment 
Range on Protein: 1469-1746
Range on HMM: 3-279/283.0
LKSNDNQKFSQEYESIEPGQQFTWDNSnLEHNKSKNRYANVTAYDHSRVQLPAVEGvvgsDYINANYCD---GYRKHNAYVATQGPLQETFVDFWRMCWE
|..|.|. | . .. .   .. .  .|  ..|| |||. .. ..|  ||.| .       ||||| .      |.. . |...|.||..| ||||.| ..
lrvnnnklfrevlkrlsvpdldadias.adenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfd

LKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQ-GFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPP
 | ..|||.|.| |  |||| |||| ||.| ||.  ||. .     ...|. . |  .   ..   .   |.  | . |       ...| .     |  
ekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqtes

ESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLH
. ||..||||.|.|||. .| . . .. .. | ..|..  |. .| ||  .||| ||| ..|...||  .|| |.. | .|.
kkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlq
subfamily_CG7180_pd Subfamily CG7180 1775-2024 3.4e-63 208.0 In-house 28-290 (296) alignment 
Range on Protein: 1775-2024
Range on HMM: 28-290/296.0
KMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGReKC
.... .  ..    |. ||| |...||.  ||.|. ..| | |||.||...|..    .||  ..|.... ..|||.......  ||.|||  .. . ..
rleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.my

FQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDA----------RDGSSRTVRQFQFIDWPE-QGVPKSGEGFIDFIGQVHKTKEQF---GQDGPI
 .||| .   .|.  .|. . | .... | |.||.|             .   |.|..||.  |.  . || | ...|... .|.. .|.     . ||.
psywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPv

TVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
 |..| |..||||.... . || .. |. .|||. |. || .|| .|.. ..|...|   ||..
vvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1456-1771 9.8e-63 206.9 In-house 3-274 (392) alignment 
Range on Protein: 1456-1771
Range on HMM: 3-274/392.0
PIPISEFANHIERlkSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQET
|||...|   .|.     .  |..|.  .   . .    .. | |. |||| |.  || .||.|  .. .  |||.|| | ...  ..||.|.|||   .
pipvaqfpafvek..nrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas

FVDFWRMCWELKTATIVMMTRLEERTrikcdqywptrgtetygqifvtitetqelatysirtfqlcrQGfNDRREIKQLQFTAWPDHGVPDHPAPFLQFL
. ||||| .. ...||.|.|.|.|                                           .| .| | . | .|| |||..|| | . .|.|.
lddfwrmvfqenvttiamvtklkegd.........................................kg.ddartvaqfhftewPdkdvpkhtssllkfi

RRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEVPARNLHTHLQKLLIT
.  .|     . |.|.||||||||||  | |||.. . |. ...|..  || .| .| |||||..|| ||. |.|| ..   | .|   .  |||.|  .
kevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlsts

EPGETISGMEVEFKKL
  |.. | .  ||..|
sdGdvrskqlkefrsl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1766-2025 1.1e-62 207.1 In-house 27-289 (325) alignment 
Range on Protein: 1766-2025
Range on HMM: 27-289/325.0
VEFKKLSNVkmDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTK
 ||. | ..  |.  . .| .| || |||.  ..... ||| |   .    |||.|||..  .. .  ..||| |  .. .|.||.. . ....||.| .
hefgllpsd..dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlne

LkEMGREKCFQYWPHE--RSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQ----DGP
| . | ..| .|||.|   |...    |  ..  ..  |  | ..| ....| .|.|.|||.  |.. ||.|    .| ..  |.. .|.        .|
l.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastp

ITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLG
| |||||||||.||||.|  .|...  |  .|.|. |. || .||.||.| ||| ..| |  |.. 
ilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_PTPN1_pd Subfamily PTPN1 1476-1735 1.2e-62 206.2 In-house 7-273 (290) alignment 
Range on Protein: 1476-1735
Range on HMM: 7-273/290.0
KFSQEYESIEP-GQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGvvgsDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMM
.... |. |.   ..|.  ...|..|...||| .|. |||||..|   .     |||||.  .  . .  |. ||||| .|   ||.| || |. ..||.
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml

TRLEERTRIKCDQYWPTRGT--E-TYG--QIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAL--TPPESG
 .. |. .||| ||||.     | ..   .. |.. ....  .| .|...|  .  .. ||| .  .|.||| |||. || ||.|| ..|      .. |
nkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvG

PVIVHCSAGVGRTGCYIVIDSMLERMKHEKI---IDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIIC
|...|||||.||.| ....|..| ......    .||  ..  || .|  ..|| ||  | . |||| . .
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1786-2024 1.1e-61 203.2 In-house 17-264 (270) alignment 
Range on Protein: 1786-2024
Range on HMM: 17-264/270.0
LPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRY-RSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSV
   .|. ||   |||   .|| | ...  . . |.|| .. |.   . .||||.||.. . ..||||.||...| .||.|.|.| ||.|| .|||.|.  
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

--RYQYYVVDPIA--EYNMPQYKLREFKVTdaRDGSSRTVRQFQFIDWPEQGVPKSGE------GFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVF
  ....  .  .|  | ..  | |.. ...  ..|..| .  |.. .||..|||.. .        .  . .|....... . .|. |||||||||.|..
kvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

ITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
|.| |... .. .. .|| . .. || .|.|.||. .||.| |.| .|| 
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_PTPN23_pd Subfamily PTPN23 1761-2024 1.5e-60 199.5 In-house 14-280 (288) alignment 
Range on Protein: 1761-2024
Range on HMM: 14-280/288.0
ISGMEVEFKKLSNVK-MDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTpihgIEGSDYVNASFIDGYRYRS-AYIAAQGPVQDAAEDFWRMLWEHNST
 .... .||.| . .  .. |. .|   .. .|||   ||||...|| |      .  ||.||||. .    .  .||.|.| | .. |||.|..|  | 
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkss

IVVMLTKLKEMGREKCFQYWPHER--SVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHK--TKEQF
..|||.. .|.|..|. .|||...  .|... . |    . .....  |..|..  .    ..|.  |.  ||| |||.| | ...|...|..  ...| 
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqr

GQDGPITVHCSAGVGRSGVFI-TLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
  . |. |||||||||.|||    ..| |  . .|.||. | |. || ||  |||...|..|.| | ||. 
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPRN_pd Subfamily PTPRN 1764-2022 2.4e-60 198.8 In-house 31-290 (297) alignment 
Range on Protein: 1764-2022
Range on HMM: 31-290/297.0
MEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYR-SAYIAAQGPVQDAAEDFWRMLWEHNSTIVVM
.| |.. | . . . |   .|. . | .|||  ..|||. ||| |.     | |||.|||.|     | .||||.|||. .   |||.|.||. ....|.
lekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivn

LTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNM-PQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPIT
||.|.| | ..| .|||.| |  |. | |. ..|.    .| .| | . . .   .||| || |. |||.||| |   ...|  .| |.    |.  || 
ltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..Grscpiv

VHCSAGVGRSGVFITLSIVLERMQyEGV--LDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE
||||.|.||.||.| . .||.|..  ||  .|.  |.  || ||| .|.|.||..|.. |  |
vhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1763-2031 7.2e-60 197.2 In-house 16-300 (301) alignment 
Range on Protein: 1763-2031
Range on HMM: 16-300/301.0
GMEVEFKKLSNVKMDSSKFVTANlpCNKHKNRLVHILPYESSRVYLTPIHG--IEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIV
..| ..|.|.... .|..  . .   ||. ||  .| .|.  |. |.| .   .   .|.|||.||||. . ..||||||..    ||||..|..  . .
kfeeqykelkegedksctvglse..enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLTKLKEMGREKCFQYWPHERSVRYQYYVV--DPIAEYNMPQYKLREFKVT--D-------------ARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDF
||.|.|||  ..||.||||. .  ..... .    . |...|.. .|...|.  |              .| ||..| |.| .|||..|| .     .  
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqv

IGQVHKTKEQFGqDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNYT
| .| ... . |  ||. ||||..|.||||....|| ||  . ||| |||| .. .| ..| .|.| .|| . | .  .||   . |.
iddvihrqqkig.ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstya
subfamily_PTPN14_pd Subfamily PTPN14 1474-1732 2.1e-59 196.0 In-house 22-295 (300) alignment 
Range on Protein: 1474-1732
Range on HMM: 22-295/300.0
NQKFSQEYESIEPGQQ-FTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVvGSDYINANYCDG--YRKHNAYVATQGPLQETFVDFWRMCWELKTAT
. |  .||| | . ..  . . ..|. |..|||. .|  |...||.| . .    ..||||         |.  |...||||. |  |||.| || ... 
egkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IVMMTRLEERTRIKCDQYWPTR----GTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTP---
|||.|. ||  . |. .|.|       | ..|.  ||   ...  ..  ....|     ...|..  ||.| |||||||. . .||..|.. ...     
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktn

P------ESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEA
       .. ||.|||||||||||  |. | ... ..|.. |||   .. || || ..|||  || |....... 
seveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1470-1735 4.1e-59 194.7 In-house 10-295 (301) alignment 
Range on Protein: 1470-1735
Range on HMM: 10-295/301.0
KSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEG--VVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELK
 .. ..||...|.... |.. . . .  |.||  ||. |.| ||. |. |   .   .   .||||.| |||.......|.|||...| |||||. |. |
aakhsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

TATIVMMTRLEERTRIKCDQYWPTR--GTETYGQIFVTITETQELATYSIRTFQL-CRQGFN--------------DRREIKQLQFTAWPDHGVPDHPAP
...|||.| |.|.|. || ||||.    .|..|.. ||....| .  . || ...  ..|.|              . ... ||| | ||..||   |. 
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

FLQFLRR-CRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIIC
 || .     .   .. |||.||||..|.|.| |. ..  ||  | | ..|... .  .| ..  .|.| .||..|.|.| . . .
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1497-1731 6.9e-59 194.0 In-house 17-262 (270) alignment 
Range on Protein: 1497-1731
Range on HMM: 17-262/270.0
LEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYR-KHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTE
  ..|  ||||..    ..||.|. .|    . ||||||  |.  ....|.|..|||. |  .|||| || |. .|||.| |||. | ||..|||..  |
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

----TYGQIFVTITETQELATYSIRTFQLCRQGfnDRREIKQLQFTAWPDHGVPDHPA------PFLQFLRRCRALTPPE--SGPVIVHCSAGVGRTGCY
    ..|.| |. ....    | ..  .| ..|  ..|..   ....||||||| ..         |. ||  |. .     ..|..|||||||||||. 
kvkledgkikvlalseekeegyiltrlrleekg..eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

IVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
|..| ... ....| .|.   .. || .|  .||. .|| |.. |..|
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_PTPN23_pd Subfamily PTPN23 1466-1732 1.2e-58 193.2 In-house 6-279 (288) alignment 
Range on Protein: 1466-1732
Range on HMM: 6-279/288.0
IERLKSNDNQKFSQEYESIEPGQQFTWDNS---NLEHNKSKNRYANVTAYDHSRVQLPavegVVGSDYINANYCDGYRKH-NAYVATQGPLQETFVDFWR
..| . ... .. .... .|  |.    .      . . .|||. ..  |||.||.|         ||||| .  .       ..|||.|||.|  |||.
lqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWl

MCWELKTATIVMMTRLEERTRIKCDQYWPTRG--TETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCR
| .| |. .|||..  ||. . |.|.|||..   |...|.. ||. ...|. |.. |...|  .. .  .... ||.|.||..|||. |  .||||   .
mvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

A----LTPPESGPVIVHCSAGVGRTGCYIVIDSMLERM-KHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEA
.       .   |..||||||||||| . .. . .. . |.. ..||   |  ||.|| .|||...|. |  .|.|||
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0051429 (Phosphotyrosine protein) phosphatases II 1528-1752 3.7e-58 192.6 In-house 4-243 (272) alignment 
Range on Protein: 1528-1752
Range on HMM: 4-243/272.0
SDYINANYCDGYRK---HNAYVATQGPLQETFVDFWRMcWELKTATIVMMTRLEERTRIKCDQYWP------------TRGTETYGQIFVTITETQELAT
|.||||.. .|| .    ... ...|||. |  ||||. .||.  |||.....||| | |||.|||            .  | .||...||..... |  
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YSIRTFQLCRQ-GFNDRREIKQLQFTAWPDHGVPDHPapFLQFLRRCRAltppeSGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIID--------IYG
| .|...| .. . .. ||. .|..|.|||||||...  .|..|. ...     .|||.||||||..|||...... .|... .| |.|        ...
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

HVTCLRAQRNYMVQTEDQYIFIHDAILEAiICGVTEVPARNLHTHLQKL
 |  ||||| ..||||.||.|...|.||. ......|.|. |...|. .
aveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldai
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1767-2023 1.6e-57 189.5 In-house 15-276 (287) alignment 
Range on Protein: 1767-2023
Range on HMM: 15-276/287.0
EFKKLSNV-KMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTpIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTK
|...| .  .  .  | .|.   . .|||  ..||.. .|| |.  .|  ||||.|| .. .|.   |.||||||.  .  ||||...|..|. |...|.
evdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr

LKEMGREKCFQYWPHE-RSVRYQYYVV-DPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQV--HK-TKEQFGQDGPI
  | .| ||..|||   . .|   | |     .   |.|  | ... |.    .| |.|.....||..... .  |.| |. .|  |   . .  . ||.
eveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPl

TVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY
 ||...|.||||..... ....|..  | .|| ..|  || .| |.||.  |. . | |   |
vvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_PTPRN_pd Subfamily PTPRN 1473-1732 2.1e-57 189.1 In-house 27-291 (297) alignment 
Range on Protein: 1473-1732
Range on HMM: 27-291/297.0
DNQKFSQEYESIEPG--QQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANY-CDGYRKHNAYVATQGPLQETFVDFWRMCWELKTA
.......|.|..     .. | . .. |.| .|||...| .||||||.| .      ||||||    |   .. ||.|||||| .|  |||.| ||  ..
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

TIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTI-TETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGP
 ||..|||||    .|..|||  |.|.|.   | . .|      | .|.| |     .. | . |. | .||..|||  . ..|.| |.        | |
vivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscp

VIVHCSAGVGRTGCYIVIDSMLERMK-HEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEA
..||||.|.||||.||.|| .|.|..   | |||   .  || ||. .|.|.||. |.  |. | 
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
subfamily_PTPN1_pd Subfamily PTPN1 1773-2022 2.2e-56 185.7 In-house 14-269 (290) alignment 
Range on Protein: 1773-2022
Range on HMM: 14-269/290.0
NVKMDSS--KFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGiegsDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMG
... ..|  .  .|.|| |. .||   . ||. ||. |   .     ||.|||...  . .  || .|||. .... ||.|.||..|  |||| |. | .
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvveke

REKCFQYWPHERS---VRYQ--YYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCS
. ||.||||.. .   . ..   . |. |.| .  .|..| ..... .   .|.. .| .. ||. |||.|   |..|. .| ..     . ||  .|||
qikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

AGVGRSGVFITLSIVLERMQYEGV---LDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE
||.|||| |. .  .| ... ..    .|. ...  ||..|  ..|| || .| | | ||
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1763-2023 6.7e-56 184.2 In-house 7-265 (283) alignment 
Range on Protein: 1763-2023
Range on HMM: 7-265/283.0
GMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGiegsDYVNASFID---GYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTI
.... ...| .. . . . . |    ||.|||  .|.|..  || | .       ||.||.||     |.    ||.||.|....  |||.|..... | 
nnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

VVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDA-RDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFiGQVhKTKEQFGQDG
.||||||.|  |.|| ||||.. |. |  . |    |.    .  .|. .       |.  .  .|.||| | |     . .. |  .| ... .  ..|
ivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkf.nkv.islqteskkg

PITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY
|| ||||.|.||..|||..|  .. .. | |.|||..|.|.| ||. .||| ||| . . ..|| 
PivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1487-1730 2.8e-55 182.1 In-house 25-274 (287) alignment 
Range on Protein: 1487-1730
Range on HMM: 25-274/287.0
GQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLpAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCD
.  .|. ...   . .|||||.|  .|..|| | . ||  |||||||||  .|....|..|.|||.  |  ||||. .| ..|....|||  | .| || 
sstatfkaaeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcy

QYWPTRGTE--TYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRC-----RALTPPESGPVIVHCSAGVGR
.||| |       |   | .  ..    |..|...|     .. | .|||.. .|||....     ...|   .      |    | ||..||...|.||
kywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGr

TGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAIL
.| .. .  ...|..    .|.   |  || .|. .||.  |. .. .|. 
sGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1768-2024 1e-54 180.6 In-house 26-279 (439) alignment 
Range on Protein: 1768-2024
Range on HMM: 26-279/439.0
FKKLSNVKMD-SSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKL
|.|.. .. | . .   |    .. |||   . ... .|| |  | |.  | |.|| .|.||     |||.||| .....||||...|.... .||||.|
fekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnl

KEmgrekCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGS--SRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQfGQDGPITVHC
 |      ..||| .  | |   .|    . ..|.| .| ||| . || .   ||| ||..| ||.. ||      .||.  .  ....  . ||. |||
ve.....sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandk.eeygpvvvhc

SAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
||||||.|  |.| | ||... |  .|.   |..|| ||  |||.  || | | | || .
sagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
0051429 (Phosphotyrosine protein) phosphatases II 1814-2026 5.1e-54 179.0 In-house 1-227 (272) alignment 
Range on Protein: 1814-2026
Range on HMM: 1-227/272.0
IEGSDYVNASFIDGYRY---RSAYIAAQGPVQDAAEDFWRMlWEHNSTIVVMLTKLKEMGREKCFQYWP------------HERSVRYQYYVVDPIAEYN
.. |.|.||....|| .   . ......|| .  |.||||. .|.. . .|.|... |.||.||..|||            .. ...| ...|  . |..
lplsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

MPQYKLREFKVTDA-RDGSSRTVRQFQFIDWPEQGVPKSGegFIDFIGQVHKtkeqfgqDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLD------
.. | |||. .|     | .|.|......|||  |||..   ..... ....       .||. ||||||..|.|... | ..|... .| ..|      
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--VFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS
  ....|. ||.|||..||||.||.|.|.|.||.| |
lyleeaveelraqrpgavqteeqylflyeallellrs
0041856 (Phosphotyrosine protein) phosphatases II 1500-1740 2e-53 176.0 In-house 1-178 (182) alignment 
Range on Protein: 1500-1740
Range on HMM: 1-178/182.0
NKSKNRYANVTAYDHSRvqlpavegvvGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTrleertrikCDQYWPTRGtetygq
|..|||| ..  |||||          ..||||||. .|..... ..||||||..|. ||.|| .||.  |||..|         ...|||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

ifvtitetqelatysirtfqlcrqgfndRREIKQLQFTAWPDHGVPDhPAPFLQFLRRCRAltppESGPVIVHCSAGVGRTGCYIVIDSMLERmkheKiI
                             |.. |.... |||||||| .  .|.|......    |.|||.|||||||||||...... |...    . .
............................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.v

DIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEV
...  |  .| .|. ||.|..||.|...|.|| . ...|..
sleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1781-2024 2.8e-53 175.7 In-house 37-236 (392) alignment 
Range on Protein: 1781-2024
Range on HMM: 37-236/392.0
FVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGrekcfqywph
  .|. . |..|||   ||||.|.|| |  |  |  |||.|||.|...    ||||.|||   . .|||||....| | ..|.|||||            
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

ersvryqyyvvdpiaeynmpqyklrefkvtdaRDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVhktKEQFGQDG-PITVHCSAGVGRSGVFITLSI
                                .  . ||| ||.| .||...|||    .. || .|   | .|||   |. .||||||||.|| |..  
................................kgddartvaqfhftewPdkdvpkhtssllkfikev...kadfGqythpliihcsagvgrtgvvisids

VLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
|. . .   ..|||. |  .| .|| ||||..|| | | | || |
vvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
0036282 (Phosphotyrosine protein) phosphatases II 1816-2018 1.3e-51 170.0 In-house 1-164 (174) alignment 
Range on Protein: 1816-2018
Range on HMM: 1-164/174.0
GSDYVNASFIDGYRYRSAYIAAQGPVQdaaedFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHersvryqyyvvdpiaeynmpqyklrefkvtdARDG
|||| |||..|...  . .|| ||| .     ||.||.|...|.||||...||.|..||..|||                                 |. 
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

SSRTVRQFQFIDWPEQGVPKSGEgFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRSGVFITLSIVLERMQyEGVLDVFQTVRILRSQRPAMVQTEDQYHF
 .|.. |.... ||  ||| . . ...|. .|..  .. ...||. |||||||||.|... . ..| ..  |.. |....|| ||.||| ||||..||.|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

CYR
.| 
lyy
0041856 (Phosphotyrosine protein) phosphatases II 1789-2025 2.7e-51 169.0 In-house 1-172 (182) alignment 
Range on Protein: 1789-2025
Range on HMM: 1-172/182.0
NKHKNRLVHILPYESSRvyltpihgieGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTklkemgrekCFQYWPhersvryqy
|..||| ..||||. ||          ..||.||....|... . .||.||| ..  .||.|||.|.. |..|.||         ...|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

yvvdpiaeynmpqyklrefkvtdarDGSSRTVRQFQFIDWPEQGVPKsGEGFIDFIGQVHKtkeqfgQDGPITVHCSAGVGRSGVFITLSIVLERmqyeG
                         .   |.. |.... ||  |||   . ..||| .|..      ..||. |||||||||.|... . .....    |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgtlvaaylmkkl....g

vLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLG
 ......|. .||.|| ||.|..|| |...|.||.| 
.vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1789-2022 1.5e-50 166.7 In-house 3-237 (237) alignment 
Range on Protein: 1789-2022
Range on HMM: 3-237/237.0
NKHKNRLVHILPYESSRVYLTPIHGieGSDYVNASFIDGYRY-RSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPH-ERSVRY
|| |||   |  |. ||| |    .  ||||.||....|.      |||||||.. . .|||.|.|. . ...|||| | |  ..|| .|||  ..   |
nkiknrygnivaydhsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

QYYVVDPIAEYNMPQYKLREFKVTDAR-DGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQ
  . |    . .. .| .| . ..        | . |.||  ||..|||.    .. |  .. .  .   . ||  .||||||||.|.|. .  .| . .
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

YEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE
 . |.|... |  .  .|| ..||.||| | ... ||
ekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1788-2022 6.4e-49 161.2 In-house 6-238 (239) alignment 
Range on Protein: 1788-2022
Range on HMM: 6-238/239.0
CNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRY-RSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRY
 || |||   |. |. ||| |  .     |||.|||..  |     ||||.|| |. .. |||||.|.    ..|||| | |  ..||.||||   |   
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

QYYVVDPIAEyNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQY
.  |    .|  . .| .| | ...  .   | | |..|  ||..|||.     . .  ..  ||. .    |  .||||||||.| |. .  .| . . 
nlrvtlrkte.vfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE
.  .|.|. |. .| .|| |||| .|| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle
0036282 (Phosphotyrosine protein) phosphatases II 1527-1727 7.4e-49 161.1 In-house 1-164 (174) alignment 
Range on Protein: 1527-1727
Range on HMM: 1-164/174.0
GSDYINANYCDGYRKHNAYVATQGPLQetfvdFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTrgtetygqifvtitetqelatysirtfqlcrQGFN
|||||||...|...  . ..|.||||.     ||.|..||.  |.||.....|. . || .|||.                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lred

DRREIKQLQFTAWPDHGVPDHPApFLQFLRRCRALTPP-ESGPVIVHCSAGVGRTGCYIVIDSMLERMKhEKIIDIYGHVTCLRAQRNYMVQTEDQYIFI
 .|.. |.... |||||||| .  .|.|.....      ..|||.|||||||||||. .... || ... |. .|.. .|  || || .||||..||.|.
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl

HD
..
yy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1788-2022 8.4e-49 160.9 In-house 7-239 (239) alignment 
Range on Protein: 1788-2022
Range on HMM: 7-239/239.0
CNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRY-RSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRY
 || |||   |. |. ||| |  .     |||.|||..  |     ||||.|| |. .. |||||.|.    ..|||| | |  ..||.||||   |   
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

QYYVVDPIAEyNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVhkTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQY
.  |    .|  . .| .| | ...  .   | | |..|  ||..|||.     . .  ..  ||. .    |  .||||||||.| |. .  .| . . 
nlrvtlrkte.vfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgrtgaflvidamlrqakk

EGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE
.  .|.|. |. .| .|| |||| .|| | . | ||
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_ptpA1_pd Subfamily ptpA1 1461-1695 4.9e-48 158.9 In-house 12-258 (418) alignment 
Range on Protein: 1461-1695
Range on HMM: 12-258/418.0
EFANHIERLKSNdNQKFSQEYESIEPGQQFtwdNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKhNAYVATQGPLQETFVDFW
.. |||. ..   ...|    ||. | .     . . .|| |||||.|.   .|.||||  ..   ||||||||| ||    . ...||||| .|  |||
nlknhikcihki.keefrlleesvgpsets...egdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfw

RMCWELKTATIVMMTRLEERTRIKCDQYWPTR-----------GTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPA
|| || .   |||..|  |  |||||.||| .           | | .|   | . |  .     | | ..      . |.| | |.  |||| .|||  
rmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtq

PFLQFLR----RCRALTPP--ESGPVIVHCSAGVGRTGCYIVIDSMLERMKH
|| |.|.    |   . |      |.|||||||||||| .     |.... |
pfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldh
0049772 (Phosphotyrosine protein) phosphatases II 1762-2027 1.1e-46 155.4 In-house 19-283 (314) alignment 
Range on Protein: 1762-2027
Range on HMM: 19-283/314.0
SGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYEsSRVYLtPIHGIEGSDYVNASFIDGYryrSAYIAAQGPVQDAAEDF----------WRM
 ....... .| . . .  ...|.|..|..|||  .|||.. .|| | |  ...|||| |||..||.    ..||.||| .   .||          |||
lklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrm

L--WEHNSTIVVM---------------------LTKLKEMGREKCFQYWPHERsvryqyyvvdpiaeynmpqyklrefKVTDARDGSSRTVRQFQFIDW
   ...|. ..||                     |..| . | | ....... .                         .... ..  .|.. ..  |..
vlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk.........................eelydpelferlgikylripv

PEQGVPkSGEGFIDFIGQVHKTkeqfGQDGPITVHCSAGVGRSGVFITLSIVLERMqyeGVlDVFQTVRILRSQRP-----AMVQTEDQYHFCYRAALEY
|  ..| . | | .|.  ...      ..||. |||.||.||.|.|... ... ..   || .. .... .|..||      .... .|| |...| |||
pDgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealley

LGSF
|  .
lkfl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1475-1731 7.8e-46 151.0 In-house 27-281 (290) alignment 
Range on Protein: 1475-1731
Range on HMM: 27-281/290.0
QKFSQEY----ESIEPGQQFtwDNSNLEHNK--SKNRYANVTAYDHSRVQLpaVEGVVGsDYINANYCDGYRkhNAYVATQGPLQETFVDFWRMCWELKT
.....||        |.|..  . . ...|    |||| .|.  | .|| |   .|  | ||. ||| .| .    .. |||.|..| .|.|||  . |.
delakeyleklkpylpvqyl..erkifdkntefkknrykdvvcndktrvil..kdGydG.dyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekv

ATIVMMTRLEERTRIKCDQYWPTRGTE--TYGQIFVTITETQEL-ATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALtppe
|.|||.  | |  . ||.||.| .  |  |.|.| |. .| ..  |    .|. .  .       .| |.  .|||. |.     .|. ||  | .    
aaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....

SGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
||||.||||||.|||| .. |.  |. . . | .|. . |  ||  |   || . ||. . ...|.
sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
0046846 (Phosphotyrosine protein) phosphatases II 1809-2025 8e-45 148.0 In-house 4-174 (176) alignment 
Range on Protein: 1809-2025
Range on HMM: 4-174/176.0
TPIHGIEGSDYVNASFIDGYRyrsaYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYqyyvvdpiaeynmpqyklrefk
....  ...||.||..|.|.|    .|| |||. .  .||..||.|.. |.||.||...|.|| ||..||| .... .                      
rllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

vtdardgssrtvrQFQFIDWPEQGVPKSgEGFIDFIGQVHKTKEQfgqDGPITVHCSAGVGRSGVFITLSivleRMQYEGVLDVFQTVRILRSQRP-AMV
             |.....||. ||| . | ..... ....  ..   .||. ||||||.||.|... .      ...|  |.|..... .|.|||  .|
.............qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTEDQYHFCYRAALEYLG
||..||.|.|...|..|.
qtpeQyrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 1815-2017 1.1e-44 147.5 In-house 3-154 (172) alignment 
Range on Protein: 1815-2017
Range on HMM: 3-154/172.0
EGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLkemgrekcfqywphersvryqyyvvdpiaeynmpqyklrefkvTDARD
|||||.|||..|.|.    .|| ||| .   .||||||.|.. |..|.||.|                                           .  ..
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

GSSRTVRQFQFIDWPEQGVPkSGEGFIDFIGQVHKTKeQFGQDGPITVHCSAGVGRSGVFITLSIVLERMqyegvlDVFQTVRILRSQRPAMVQTEDQYH
. .|.. |.... || .||| . | ...|. ....   .  ..||. |||||||||.|... . ..|...      .....|. .|..|| .||...||.
llerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyr

FCY
|.|
fly
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1494-1733 3.3e-44 146.1 In-house 35-277 (307) alignment 
Range on Protein: 1494-1733
Range on HMM: 35-277/307.0
NSNLEHNKSKNRYANVTAYDHSRVQLpAVEGVvGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRG
   .. |  |||| .| . |..|. .  ..|.  |||| |||     | . ....||||..|  .|| |. . |  ...|. .. | ..|||.||||   
veafsantdknryqdvkcqdkgrivv.kfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

--TETYGQIFVTITE----TQELAT--YSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAltppESGPVIVHCSAGVGRTGCYIV
  . ..|.   ||.     ...||     |   .|  .  .. | |..||.. |||.|||.     . .|   |     .  ||.|||||||||.|  . 
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtiva

IDSMLERM-KHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
|  . ..| . .   |.   |  ||.||.| .||| ||...|  .||  
islvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
0043147 (Phosphotyrosine protein) phosphatases II 1527-1726 1.1e-43 144.2 In-house 4-154 (172) alignment 
Range on Protein: 1527-1726
Range on HMM: 4-154/172.0
GSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLeertrikcdqywptrgtetygqifvtitetqelatysirtfqlCRQGFN
|||||||.| |.|.. . ..||||||..|. |||||..||.  .||..|.|                                           .  . .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

DRREIKQLQFTAWPDHGVPdHPAPFLQFLRRCRA-LTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMkhekiiDIYGHVTCLRAQRNYMVQTEDQYIFI
  |.. |.... ||||||| ... .|.||. ..  |   ..|||.|||||||||||. .... ||...      ...  |  .|..|...||...||.|.
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllgl......sleeavalvrekRpgavqnpsqyrfl

H
.
y
0049772 (Phosphotyrosine protein) phosphatases II 1490-1732 2.2e-43 144.5 In-house 36-279 (314) alignment 
Range on Protein: 1490-1732
Range on HMM: 36-279/314.0
FTWDNSNLEHNKSKNRYANVTAYDhSRVQLPaVEGVVGSDYINANYCDGYrkhNAYVATQGPLQETFVDF----------WRMC--WELKTATIVM----
.|.  ..|. |..|||| ..  .| .||.||  ..| |||||||.| ||.   ....||||||..|.|||          |||   ..|.. .|||    
ltilvadlflnrdknryldilpad.nrvilp.glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrde

-----------------MTRLEERTRIKCDQYWPTRGtetygqifvtiT-------EtqelatysirtfqlcrqgfndRREIKQLQFTAWPDHGVPdHPA
                  ..| ... . . .....             .                              |.. ..  . .||...|  ..
vladelsrLdaAlgKtpllildgngneptaadlellk...........eelydpelf.....................erlgikylripvpDgsap.lle

PFLQFLRRCRALtpPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHeKIIDIYGHVTCLRAqRN---YMVQTEDQYIFIHDAILEA
 |..||. ....  .. |||.|||.||.||||...|.. .. ...   . ... .|   |   |    .... .||.||..|.||.
dfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfieqleqyefilealley
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1473-1731 5.4e-43 141.9 In-house 4-257 (267) alignment 
Range on Protein: 1473-1731
Range on HMM: 4-257/267.0
DNQKFSQEYESIEPGQQFTW--DNSNLEHNKSKNRYANVTAYDHSRVQLPAVEgvvgSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTAT
..... .|.| |.   . .     |  |.|. .||. ..  ||..|| |   |     .|||| | .||.. ||...||.||. |  ||. .  . | ..
eeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpv

IVMMTRLEERtriKCDQYWPTR--GTETYGQIFVTITETQELATYSIRTFQLCRQGfNDRREIKQLQFTAWpdhGVPDHPAPFLQFLRRCRALTPPESG-
||..|.  .    .  ..|| .   .. | .. |  .  .|   | | |..|  .  .  ...    .  |    .     |.|. |    |    | | 
ivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkw...nintnnkpylkplfgilaknqlengn

-PVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
 |..|.||.||||.| ..||||.|||.|.| . ||.  .  .| ||  .|.| ..||.||. . |
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
0046846 (Phosphotyrosine protein) phosphatases II 1526-1731 2e-42 140.2 In-house 10-171 (176) alignment 
Range on Protein: 1526-1731
Range on HMM: 10-171/176.0
VGSDYINANYCDGYRkhnaYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYgqifvtitetqelatysirtfqlcrqgf
 ..||||||. .|.|    ..|||||| .|. ||..| .||.  ..|..| . |  |.||..|||   .. .                            
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

ndrreikQLQFTAWPDHGVPDHpAPFLQFLRRCRALTPPEsGPVIVHCSAGVGRTGCYIVIDsmleRMKHEKIIDIYGHVTCLRAQRN-YMVQTEDQYIF
       | ... ||||||||. . .|..|. .|       |||.||||||.||||......     ...|| ....  .  .|.||  ..|||..|| |
.......qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrf

IHDAILE
.....|.
lyefell
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1764-2023 3.4e-42 139.3 In-house 8-258 (267) alignment 
Range on Protein: 1764-2023
Range on HMM: 8-258/267.0
MEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPihgiEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVML
.| ||... ..  .||.  .     |. .||| . |||. .|| |      .  .|.|||...||. . |.|. |.|.. .  ||. .. ... ...|.|
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivll

TKlkeMGREKCFQYWPHE--RSVRYQYYVVDPIAEYNMPQYKLREFKVTdARDGSSRTVRQFQFIDWPEQGVPKSgeGFIDFIGQVHKTKEQFGqDGPIT
||    . ..  ..|| .  .. .||  .|.   | .  .|..  ...   .. |.. |  . .  |  .   |    .  ..| . | . . | . |. 
tk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykkwnintnnkp..ylkplfgilaknqleng.nrPlv

VHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY
|.||.|||||| |...   |||.. |||.|.|. .| .||||...|.| ..| ....   ||
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
0049260 (Phosphotyrosine protein) phosphatases II 1824-2017 2.6e-41 136.1 In-house 1-143 (152) alignment 
Range on Protein: 1824-2017
Range on HMM: 1-143/152.0
FIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWphersvryqyyvvdpiaeynmpqyklrefkvtdardgssrtvrQF
|||||..  ..||.|||    ..||||||.|.. |..||||.| |.|..|| ||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

QFIDWPEQGVPKSGEGFIDFIGQVHKTkeQFGQDGPITVHCSAGVGRSGVFITLSIVLermqyeGVLDVFQTVRILRSQRPAMVQTEDQYHFCY
... ||  |||.. . .....  ..|   .  ..||. |||||||||.|... . ..|        ......|. .|..|| .|....|. |.|
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
0049260 (Phosphotyrosine protein) phosphatases II 1536-1727 3.7e-41 135.7 In-house 2-144 (152) alignment 
Range on Protein: 1536-1727
Range on HMM: 2-144/152.0
CDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWptrgtetygqifvtitetqelatysirtfqlcrqgfndrreikQLQ
 |||.......|||||. .|. ||||| .||.  ||||.|.|.|....||.||.                                           | .
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qyl

FTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLermkheKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHD
.. ||||||||..  .|..|. .. |   ..|||.|||||||||||...... ||      . ....  |  .|..|...|....|..|...
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0044763 (Phosphotyrosine protein) phosphatases II 1800-2023 1.2e-40 134.4 In-house 1-170 (178) alignment 
Range on Protein: 1800-2023
Range on HMM: 1-170/178.0
PYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAaqgpvqdaaEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSvryqyyvvdpiaeynm
|.. .|| |... |.|.||| |||.|... |.... .         .|....|.|.. | .|.||. .|.|..||..||| | .                
pldrtrvllsnleglersdyinaseilpglylgslpp.........addlellkelgithivnlteelelgflkcdpywpeeag................

pqyklrefkvtdardgssrtvRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfGQDGPITVHCSAGVGRSGVFITLSIVLERmqyeGVlDVFQTVRIL
                      |...| .|  ||| . | | .|.  ...  .   ..||. |||||||||||... . .....    |. .... .. .
.....................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielv

RSQRPaMVQTEDQYHFCYRAALEY
|..|| .|....|....|. .|..
rerRp.ivpnpgqlrqLyefelrl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1500-1731 8e-40 131.5 In-house 48-285 (305) alignment 
Range on Protein: 1500-1731
Range on HMM: 48-285/305.0
NKSKNRYANVTAYDHSRVQLpavEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTET---
.. |||| .|   |. ||.|   ||    .|| |||     . . .. || ||..|  ||| ||.. |  .| |.  | |.   || .|....  ..   
eagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

---YGQIFVTITETQEL-----ATYSIRTFQLCRQGF-NDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRaltpPESGPVIVHCSAGVGRTGCYIVID
     .| | .  ...|     |   ..  .|  .|  .. | ...  .  ||| |||      |..| ..|    |  ||..||||||.||||  ....
eekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagigrtgsvvmle

SMLERMKHEKIIDIYGH-VTCLRAQRNYMVQTEDQYIFIHDAILE
 .|...   .||.   . .  .| |||  .||..||.|.|. ||.
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1481-1739 2e-39 130.0 In-house 33-295 (310) alignment 
Range on Protein: 1481-1739
Range on HMM: 33-295/310.0
YESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLpAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEER
|  ..  |. .      ...  ||||..|   | |||.|  ..     ||| |||       .... .||||| | .||||| .. .. .|... .  | 
yrkldakqdssltyeaykkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgee

TRIKCDQYWPTRG-TETYGQIFVTI-TETQ---ELA----TYSIRTFQLCRQGFNDR-REIKQLQFTAWPDHGVPDHPAPFLQflrrCRALTPPESGPVI
 | ||  |||. | ||||| | ||  .|.    |.     |.      .  |  | .   .. ...  ||| ||||     .      | |.    ||..
grpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp....qrllaqvrhgpcv

VHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILeAIICGVTE
||||||..|... . ..  ...... . .|.   .| |. .|   .||| ||..|.   . ..  | ||
vhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargete
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1762-2024 3.3e-39 129.7 In-house 16-277 (307) alignment 
Range on Protein: 1762-2024
Range on HMM: 16-277/307.0
SGMEVEFKKLSNVKMDssKFVTANLPCNKHKNRLVHILPYESSRVYLTpIHGIeGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVV
. .  ||..|.. . .     .  . .| .|||   .   . .|. .. ..|.  |||. | ..        .|.|||| ...  .|| |  ...   |.
qalvdefrvlakktpe..gvtveafsantdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvi

MLTKLKEMGREKCFQYWPHERSVRYQYYV-VDPIAEYNMPQYKLRE----FKVTDA---RDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHktkeq
|| |. |... || |||| |.  .  .    . |.  |.   ||       .||.      . |||....|. .||..|||.   . |...  |.     
mlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr.....

fGQDGPITVHCSAGVGRSGVFITLSIVLERM-QYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
 ..  |. |||||||||||  ...|.| ..| . .   |. . |. |||||.  .||| || . .|  |||.
.ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1490-1733 1.5e-38 127.2 In-house 45-289 (305) alignment 
Range on Protein: 1490-1733
Range on HMM: 45-289/305.0
FTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEgvvGSDYINANYCDGY-RKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQY
    |   . ...||||..| . |.| |.|        |||| |||       .. ....||||..|  .|| |  . |   |||. .  |  ..|| ||
afnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqy

WPTRGTET----YGQIFVTITETQEL---ATYSIRTFQLCRQGfNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAltppESGPVIVHCSAGVGRTG
||.   |      | .   .. .. .   |   | ...|.  | ...  ...||.| ||| |||      |..|   |        |..||||||.||||
wpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysg.dqkmsvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtg

CYIVIDSMLERMKHEKIID-IYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
  . |. .||..  .|    .   | .|| || . .|.. ||.|||  .|. .
tivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1495-1731 1.5e-38 127.1 In-house 32-267 (281) alignment 
Range on Protein: 1495-1731
Range on HMM: 32-267/281.0
SNLEHNKSKNRYANVTAYDHSRVQLPA-VEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRG
 |   |. ||||.|. . | |||||   .     .||| |||      .  |. |||| .||  ||||| |. .|..|||. .. |  | || .|.|   
fnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

TETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAltppESGPVIVHCSAGVGRTGCYIVIDSMLERM
        ....  .     |. | .|      . | | .  .  |||  ||.    .|. ||. ||     | | ..||||||||.|  . ..  |. .
hcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira....rstppvihcsagvgrsgtlmaveialqsi

K-HEKIIDIYGHVTCLRA-QRNYMVQTEDQYIFIHDAILE
. |  . ||   |. ||   |   ||| .||..|   .|.
hshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0051082 (Phosphotyrosine protein) phosphatases II 1816-2020 5.7e-38 125.2 In-house 2-149 (151) alignment 
Range on Protein: 1816-2020
Range on HMM: 2-149/151.0
GSDYVNASFIDGYryrsaYIAAQGPvqdaAEDFWRMLWEHNSTIVVMLTKLKEMGreKCFQYWPHERsvryqyyvvdpiaeynmpqyklrefkvtdardg
 ||| |.|...|.     ... .||     .||...|.|.. . .|.|....|.|  .| .|.| .                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

ssRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKtkeqfGQDGPITVHCSAGVGRSGVFITLSIVLERmqyegvLDVFQTVRILRSQRPAMVQTEDQYHF
  ..|......|||..|.| | . ...|. .. .      ..||. ||||||.||.|... | ..|..      ........ .|..|| .||...|. |
..ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

CYRAA
...| 
qlfal
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1771-2026 1.7e-36 120.3 In-house 17-271 (281) alignment 
Range on Protein: 1771-2026
Range on HMM: 17-271/281.0
LSNVKMD--SSKFVTANLPCNKHKNRLVHILPYESSRVYLTP-IHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLK
.||.  |  |    . | | |..||| . |   . ||| |   .   . .||. | .|     .  || .||| ...  |||||.|. |.| .||| .. 
fsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfl

EMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKtkeqfgQDGPITVHCSAG
|  |||| .|.|..  .  |.  .    |    .  |   ..  . .| .| . .. . .||.  ||.| | ..  . ...       .  |  .|||||
etnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira......rstppvihcsag

VGRSGVFITLSIVLERMQYEG-VLDVFQTVRILRS-QRPAMVQTEDQYHFCYRAALEYLGS
||||| .... | |. ..    . |. | |  ||   | | ||| .|| . ..  |..  .
vgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgva
0051082 (Phosphotyrosine protein) phosphatases II 1528-1730 2.7e-36 119.8 In-house 3-150 (151) alignment 
Range on Protein: 1528-1730
Range on HMM: 3-150/151.0
SDYINANYCDGYrkhnaYVATQGPLQetfvDFWRMCWELKTATIVMMTRLEERTriKCDQYWPTRGtetygqifvtitetqelatysirtfqlcrqgfnd
|||||..| .|.     . ...|||.    ||... .||.  |||... .|||   .| .|.|  |                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

rREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAltpPESGPVIVHCSAGVGRTGCYIVIDSMLERmkhekiIDIYGHVTCLRAQRNYMVQTEDQYIFIHD
 .|....... |||.|.|.... .|.||. ...   ...|||.||||||.||||. .... ||..      ....  .  .|..| ..||...|..|.. 
.ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

AIL
|.|
all
PTPc_DSPc_SM00012 1919-2022 2.8e-36 119.3 In-house 1-105 (105) alignment 
Range on Protein: 1919-2022
Range on HMM: 1-105/105.0
TVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYE-GVLDVFQTVRILRSQRPAMVQTEDQYHFCY
||..... .||..|||.... ..... .|.| |.. .. .|. |||||||||.|.|..|.|.|.....| . .|.||.|. ||.||| |||||.|| |.|
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

RAALE
|| ||
ralle
0044763 (Phosphotyrosine protein) phosphatases II 1512-1729 2.3e-35 117.2 In-house 2-167 (178) alignment 
Range on Protein: 1512-1729
Range on HMM: 2-167/178.0
YDHSRVQLPAVEGVVGSDYINANYCDGYrkhnAYVATQGPlqetfVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTetygqifvtitetqela
.|..|| |. .||. .||||||.. ...     |.....|     .|.... .||.  .||..|   |. ..|||.|||..                   
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

tysirtfqlcrqgfndrreiKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERmkheKIiDIYGHVTCLRAQ
                     | ... .||||||| .. ||.|.. .... ... |||.|||||||||.|. .... |...    .. ...  .  .|..
....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrer

RNyMVQTEDQYIFIHDAI
|. .|....|. ....  
Rp.ivpnpgqlrqLyefe
subfamily_ptpA1_pd Subfamily ptpA1 1767-1985 6.9e-35 115.6 In-house 26-257 (418) alignment 
Range on Protein: 1767-1985
Range on HMM: 26-257/418.0
EFKKLSNvKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGyRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKL
||. | .  .  |.    .   |  |||   ||| . .|| |  |.  |||||.|| .|||  |   .|..|||. ..  |||||.||    |.|||.. 
efrllee.svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsre

KEMGREKCFQYWPHERSV-----------RYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQF-
 |  | || .||| .               .  | |. .   . |. ..   ..  . .| .| . |.|.  ||.. .|   . | ...  . . ..|  
sencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqii

---GQDGPITVHCSAGVGRSGVFITLSIVLERMQ
    .. || |||||||||.| | |  |......
pssdrnvpiivhcsagvgrtgtfctavimmkkld
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1790-2024 1.9e-34 113.6 In-house 57-283 (290) alignment 
Range on Protein: 1790-2024
Range on HMM: 57-283/290.0
KHKNRLVHILPYESSRVYLTpiHGIEGsDYVNASFIDGYryRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERS--VRYQ
 .|||   .   . .|| |    | .| ||| | ...|   .. .| .||...|.. |.|||. ... . .||| .| | |. || ||.|..    . . 
fkknrykdvvcndktrvilk..dGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

YYVVD-PIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTkeqfgqDGPITVHCSAGVGRSGVFITLSIVLERMQY
 . |     . .  . ... . | |  .| .  .. .. . ||.. |..|   ..  .  . |.       ||..||||||.||.| |... . |. .  
eitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhcsaGiGrtGtfvaievglqilld

EGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
   ||. ..|| ||  | . || . ||    .. |.. 
GkeldlldlvralrnsrlnsvqvdiqylalveilldlG
PTPc_DSPc_SM00012 1631-1731 4.9e-34 112.1 In-house 2-105 (105) alignment 
Range on Protein: 1631-1731
Range on HMM: 2-105/105.0
IKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPES--GPVIVHCSAGVGRTGCYIVIDSMLERMKHE-KIIDIYGHVTCLRAQRNYMVQTEDQYIFIHD
.|....|.|||||||... ..|..|| ..  .  ..  .||.|||||||||||.....| .|.....| | .||.  |  || ||. |||||.||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AILE
|.||
alle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1495-1647 1.7e-32 107.4 In-house 28-182 (297) alignment 
Range on Protein: 1495-1647
Range on HMM: 28-182/297.0
SNLEHNKSKNRYANVTAYDHSRVQLpaVEGVVGSDYINANYCDG--YRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR
.. .    |||| .. |.| .||.|    .. ..|||||.|       .   |. .||||..|  |||.. .|    .|||...|.|  | ||  |||  
akrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

--GTETYGQIFVTIT--ETQELATYSIRTFQLCRQgfNDRREIKQLQFTAWPDHGVPDH
  .  . |.. |      ..|  .  .  .||  .  ...| ..  || .|||||||  
vqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsd
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1497-1737 2.4e-32 107.0 In-house 32-275 (285) alignment 
Range on Protein: 1497-1737
Range on HMM: 32-275/285.0
LEHNKSKNRYANVTAYDHSRVQLPAVEgvvgSDYINANYCDGYRK-HNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTE
 | |   ||||.| . . .|| |   .     ||| |..     | ...|..||||| ||. |||.| .. | | ..|.  | |    ||  |.| .  |
yeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

--TYGQIFVTITETQELATYSIRTFQLC----RQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESgPVIVHCSAGVGRTGCYIVIDSM
   .|.  .|.|| .| |        |      .  ..   ....|   |||.  |.   |.... .  . . | |  |. ||||||||||  .. ||  
vvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidya

LERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIIC-GV
  |.  .  |..   |  .|| |   ||.  |..|..  ..| .|  ||
tirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1497-1736 3.1e-32 106.8 In-house 40-274 (288) alignment 
Range on Protein: 1497-1736
Range on HMM: 40-274/288.0
LEHNKSKNRYANVTAYDHSRVQLPavegVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR-GTE
   | ...|| |.   | .||.|          ||.||     . ..  . .| ||. |   .|.|  |     |||...| |. . | ..|.|.. | .
fianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

TYGQIFVTITETQELATYSIRTFQL---CRQGfNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTppesGPVIVHCSAGVGRTGCYIVIDSMLER
.  . . |..  .      . .  |    ..| ...  .|.| .  |.|.|||.   ..|..| . ..|.     |..||.||||||||  |.|  .|| 
arigrlctvvkkkradidklvkvsllriskeg.eekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililiales

MKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICG
.. .  . |   .. ||..|   .||| ||...|  .|| ..  
lrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1778-1947 6.8e-31 102.2 In-house 22-193 (297) alignment 
Range on Protein: 1778-1947
Range on HMM: 22-193/297.0
SSKFVTANLPCNKHKNRLVHILPYESSRVYLTpiHGIEGSDYVNASFIDG--YRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCF
. .| .|. .   .|||  .|| ....|| |    .| ..||.|| ..          || ||||.... .|||....|..  ..||..||.| ||.||.
gesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

QYWPHERSVRY--QYYVVDPIAEYNMP--QYKLREFKVTDArdGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQV
 |||.    |     .||. ....     . .| |...       || ||  ||. ||. |||   |    |  ||
pywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1781-2015 1.3e-29 97.9 In-house 44-272 (301) alignment 
Range on Protein: 1781-2015
Range on HMM: 44-272/301.0
FVTANLPCNKHKNRLVHILPYESSRVYLT----PIHgiegsdyvnASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQ
   | || .||.   |   |  . .|       |||         | .|.       .||.|||.....|||| ||  ..   .|||..  |   ||| .
esyaylpkdkhryptvPckPstavevivdGkrvPih.........anwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekcee

YWPHERS--VRYQYYVVDPIAEYNM--PQYKLREFKVTDAR-DGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqdgPITVHCSAGVGRS
| | . |  .. . . .    .  .   . . |...|.|.  . ..|||  .|. .|...|||||     |..  | |...      || ||||||.|||
ylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiGrs

GVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHF
  ||.  ..  ... .  ... .... || .|   |||. | ..
vafigteylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_egg_pd Subfamily egg 1491-1731 1.5e-29 97.7 In-house 31-271 (307) alignment 
Range on Protein: 1491-1731
Range on HMM: 31-271/307.0
TWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERtrIKCDQYWP
.  ..  . |. | |   |   | |||.|   .|    |.| ||. .|    | .. .| ||..|  ||||| .. .   |||.|   |    .|. |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

TRGTETY----GQIFVTITETQELATYSIRTFQLCRQGFNdrREIKQLQFTAWPDHGVPDHPAPFlQFLRRCRALtppeSGPVIVHCSAGVGRTGCYIVI
   ...     | . ..  . .. |    |  .|   | .  .| . |.   .  . . |   |. . ||. | |    | ||.|..  || .... . |
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdvnnssdvyspl.rvlrklrnl....skpvvvqdilGvskaatlvai

DSMLERMKHEKII--DIYGHVTCLRAQRNYMVQTEDQYIFIHDAIL---E
.  |  .    |    .   |  || .|.. |..  .|.|..  .|    
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1788-2024 2.6e-29 96.8 In-house 54-289 (305) alignment 
Range on Protein: 1788-2024
Range on HMM: 54-289/305.0
CNKHKNRLVHILPYESSRVYLTPIHgieGSDYVNASFIDGYRY-RSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRY
 .. |||   .   . | | |        |||. | ..         .|.||||.... ..|| |. ...   .||| |  |.|. || ||||  .  . 
iaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

---QYYVVDPIAEyNMPQYKLREFKVTDAR----DGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHktkeqfGQDGPITVHCSAGVGRSGVFITLSI
      ||. ..  . |  .  | ..|  .     . . .||..|. .||..|||      ....  .       |   || ||||||.||.|  ...  
elksgivvenvsg.skpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gskvpivvhcsagigrtgtivaiey

VLERMQYE-GVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
.||..  .  .  . . |. || ||   .|.. || | .|  |.|.
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1499-1734 3e-29 96.7 In-house 42-277 (312) alignment 
Range on Protein: 1499-1734
Range on HMM: 42-277/312.0
HNKSKNRYANVTAYDHSRVQLPAVEGVvgsdYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGT-ETY
. |  ||| |.  .|  |  |   |      || ||.     | . .|.|||||..| . ||...  | ...|.... . | .  || .|     .    
kfkdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdl

G--QIFVTITETQELA-----TYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAltppESGPVIVHCSAGVGRTGCYIVIDSML
   ...       |.        . | ...  .   .   ... |...|||||.||     |..|   .     .  ||| ||||||||||  ..|.||.
edhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmi

ERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAII
  ..| .  ..      || .|   |..  ||..   ..|| . 
aalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1763-2024 2.9e-28 93.5 In-house 23-287 (305) alignment 
Range on Protein: 1763-2024
Range on HMM: 23-287/305.0
GMEVEFKKLSNVKmDSSKFVTANLPCNKHKNRLVHILPYESSRVYLtpiHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVM
|.  ||. .  .. |  |. .     ...|||   .   .  || |   .|    .|. | ..        .| .| |....  ||| | ....   . |
glraefvamkrfn.dfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifm

LTKLKEMGREKCFQYWPHERSVRYQYYVVD------PIAEYNMPQYKLREFKVTD------ARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKT
| .|.| | .||..|.. .     ..   .        .  ..   |  . |||.         ...| | .. .||||..||| .    .... .   .
lcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps

KeqfgqdGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLD-VFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
|      |||.||||||.||.|  . |  .|...    ...   . .. .| ||   .||..|| | ..  |.|.
k......gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_CG42327_pd Subfamily CG42327 1500-1659 7.9e-28 92.0 In-house 28-191 (319) alignment 
Range on Protein: 1500-1659
Range on HMM: 28-191/319.0
NKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRK-HNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR----GT
 | |.|..||    ..|| |. .     . |..|.|  ||.. .| |.|.| .|...  ||||. || .. .|| .| | |    .| .|.||.    .|
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

ETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFtAWPDHGVPDHPAPFLQFLRRCR
..||.| ||. . .    | | |. | |   .  ||.    .  |.. .|| ..|...  | . |
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1497-1724 3.8e-27 89.8 In-house 47-272 (301) alignment 
Range on Protein: 1497-1724
Range on HMM: 47-272/301.0
LEHNKSKNRYANVTAYDHSRVQLpAVEGVvgSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTET
   .| |.|| .|    .. |..  |.|      | ||. .   . . ..||||||..|  ||| |.   .  .|||...  |..  ||..| |.. .|.
aylpkdkhryptvPckPstavev.ivdGk..rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek

--YGQIFVTITETQELATYSI--RTFQLCR-QGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRAltppESGPVIVHCSAGVGRTGCYIVIDSMLE
   |.  ..|.... .   .|  ||...    |  . | .   |.. |.|.|||   |   ...   .        |..||||||.||. ..|  . .  
ldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrsvafigteylar

RMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIF
... .. |..   .  || .|   |||. |  .
eveadptieltealkhlrehrwngvqtnsqlyw
0048076 (Phosphotyrosine protein) phosphatases II 1588-1730 3.8e-27 90.1 In-house 2-140 (145) alignment 
Range on Protein: 1588-1730
Range on HMM: 2-140/145.0
YWPTRGTET--YGQIFvTITETQELATYSIRT-FQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPEsGPVIVHCSAGVGRTGCYI
|||.. ..   .| .  |  . ..|. . |.| . |..   .  |.. |.... |||||||| .. .|.||. .... . . |||.|||||||||||...
ywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv

VIDSMLErmkhEKiIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAIL
... ||.    .. ....  .  .|.|| ..|....|..|.....|
aaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1749-2021 4.7e-27 89.3 In-house 14-287 (310) alignment 
Range on Protein: 1749-2021
Range on HMM: 14-287/310.0
LQKLLITEPGETISGMEVEFKKLSnVKMDSSKFVTAnLPCNKHKNRLVHILPYESSRVYLTpIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDF
|....|.     | |.  ...||   | |||    |    . ||||   ..  ..||| |. |      ||. | ..     ||..| .|||.| .  ||
lenfiiateklgieglvkqyrkld.akqdssltyea.ykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidf

WRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERS-VRYQYYVVDPIAEYNmPQYKLREFKVTDARDGS----------SRTVRQFQFIDWPEQGVPKSG
|||...  .  ...| |  | || ||  |||       |    |  ..|    .... .. ||   |               |   .. .||..|||   
wrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdek

egfIDFIGQVHKTkeQfGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAAL
      . |   .  |  . ||  ||||||..| .| ..| . .....    .|. . .  |. .|   .||| || .  |  .
...chtvpqrlla..q.vrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1777-2024 4.8e-27 89.7 In-house 31-271 (288) alignment 
Range on Protein: 1777-2024
Range on HMM: 31-271/288.0
DSSKFVTANLPCNKHKNRLVHILPYESSRVYLTpihgIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQ
..|. .  .   |  ..|  ..   . .|| |.     .   |..|  .   .|.   | || |.. . | .|.|| | .   .|||..| | |.||  .
easidiidsfianptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksae

YWPHER--SVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRT-VRQFQFIDWPEQGVPKSGEGFIDFIGQVhktkeqFGQDGPITVHCSAGVGRSGV
|.| .   ..|.. .  .   ...  .  ..   .   . |  .  |..  . .|...|||..   .. ..  .         . || ||.||||||.| 
yfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl......kslqkPivvhssaGvGrtgt

FITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
.|   |.|| .. .  | . . .  || .|   .||| || . .|  ||.|
lililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1627-1772 6.2e-27 89.0 In-house 87-233 (440) alignment 
Range on Protein: 1627-1772
Range on HMM: 87-233/440.0
DRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCR-ALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFI
. | .|| .. .|||.|||   .| |....    .     .||..||||||.||||  |..||.|   |.   |||.  . ..| .|  |||| .|| |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDAILEAIICGVTEVPARNLHTHLQKLLITEPGETISGMEVEFKKLS
|.|.||...|| | .   ..  .....   .|    | .. ||.  |
heavlegllcgdtliledditerveqiqwpnphtdksplqqefegys
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1788-2024 7.3e-27 89.0 In-house 34-270 (285) alignment 
Range on Protein: 1788-2024
Range on HMM: 34-270/285.0
CNKHKNRLVHILPYESSRVYLTPiHgieGSDYVNASFID-GYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHE--RSV
.|   ||   .   | .|| |   |     ||. ||..    . .|.||..|||. ..  |||.|... . . |.||  | | | |||  |.| .    |
anpdlnryadvrcieetrvvlkn.h...drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

RYQYYVV--DPIAEYNMPQYKLREFKVTDARDGSSRTV--RQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPITVHCSAGVGRSGVFITLSIV
..  | .      |  .    |  . |... | ||  .   . |   ||.|  |.    .|..   |.| .    .. || |||||||||.  |. .   
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp...kekpicvhcsagvgrtatfvgidya

LERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
  |.  .  ..... || .|. |   ||.  |. | |   .||.
tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0048076 (Phosphotyrosine protein) phosphatases II 1850-2023 1.1e-25 85.5 In-house 23-142 (145) alignment 
Range on Protein: 1850-2023
Range on HMM: 23-142/145.0
RMLWEHNSTIVVMLtklkemgrekcfqywphersvryqyyvvdpiaeynmpqyklrefkvTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHK
..|.... | |. |                                              |. ... .|.. |.....||  ||| . | ...|. ....
ellkdlgittvlnl..............................................tselellerlgiqylylpwpDhgvpdllellleflefiee

TKEQfgqDGPITVHCSAGVGRSGVFItlsiVLERMQYEGvLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY
  ..   .||. |||||||||.|...    ..  | ..| ........ .||||| .|....|..|.|.. ||.
alke...ggpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 1609-1727 1.6e-25 84.9 In-house 24-139 (144) alignment 
Range on Protein: 1609-1727
Range on HMM: 24-139/144.0
ELATYSIRTF-QLCRQGFNDR--REIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPpESGPVIVHCSAGVGRTGCYIVIDSMLermkHEKiIDIYGHV
.|. . |.|   |. .  ..   ||. |.... ||||||||... .|.||. .... . |.|||.|||||||||||...... |.    ... ....  .
llkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleeal

TCLRAQRNYMVQTEDQYIFIHD
  .|..| ..|....|..|...
alvrsrrpgavpnpgqlrfLle
subfamily_CG42327_pd Subfamily CG42327 1767-1951 2e-25 84.1 In-house 10-194 (319) alignment 
Range on Protein: 1767-1951
Range on HMM: 10-194/319.0
EFKKLSNVKMDSSkfvtANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRY-RSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTK
||..| ..   .     .  .  | |.|.....|   .|| |  |   . . |..||.. ||.  .. ||||| . .|.. ||||..|| .| ..| ||.
efrdlPqliarad....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LKEMGREKCFQYWPHERSV----RYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFiDWPEQGVPKSGEGFIDFIGQVHKTK
| | | ..| .|.| . .      |  . |         .| .  . .    .  || .  . . .|.| .|| . . .|  . .|... 
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrssl
subfamily_egg_pd Subfamily egg 1759-2021 6.5e-24 79.1 In-house 11-267 (307) alignment 
Range on Protein: 1759-2021
Range on HMM: 11-267/307.0
ETISGMEVEFKkLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNST
| . ..|  .. ...   |   . ||    |..| |  ..   .|||| |   .|    |.. |  ..|      .| || |.... .|||||... .  
eivqelerrle.vleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevq

IVVMLTKLKEMgrEKCFQYWPHERSVRYQY-YVVDPIAEYNMPQYKLREFKVTDARD-GSSrtvRQFQFIDWPEQGVPKSGEGFIDFigQVHKTKEQFGQ
 .||||  ||   |.|  |||.  |   ..      |  ... .     |.||  .  |.    .. .|..  .  | .|.. .  .  .| .   .  .
yivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehwqgdvnnssdvyspl..rvlrklrnlsk

dgPITVHCSAGVGRSGVFITLSIVLERMQYEGVL--DVFQTVRILRSQRPAMVQTEDQYHFCYRAAL
  |. |..  || ........ | |  .    .    | ..|  || .|.  |..  .| | ||  |
..pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0048179 (Phosphotyrosine protein) phosphatases II 1905-2018 7.1e-24 79.6 In-house 48-139 (144) alignment 
Range on Protein: 1905-2018
Range on HMM: 48-139/144.0
RefkvtdardgssrtVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfgQDGPITVHCSAGVGRSGVFITLSivleRMQYEGvLDVFQTVRILRSQRP
               . |.....||  ||| . | ...|.  ...  |   ..||. |||||||||.|.....     .| ..| |....... .||.||
e..............giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrp

AMVQTEDQYHFCYR
 .|....|..|...
gavpnpgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1501-1609 1e-22 75.4 In-house 48-167 (350) alignment 
Range on Protein: 1501-1609
Range on HMM: 48-167/350.0
KSKNRYANVTAYDHSRVQLP--------AVEGVVGSDYINANYCDGY----RKHN--AYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCD
 .|||| |.  |.||||.|.            . ..|||||||        .      |.|||.||..|. ||.... . |   |...| . |  . ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPTRGtetYGQIFVTITETQE
.||.  .   | .| | .....|
rYWqegs...ydditvklaskwe
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1542-1726 1e-22 75.3 In-house 4-197 (199) alignment 
Range on Protein: 1542-1726
Range on HMM: 4-197/199.0
HNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR--GTETYGQIFVTITETQELATYSIRTFQLCRQG--FNDRREIKQLQFT
.  |.||| ||.||. |||.| ||  .  |||.   .         ||||   ||  || . ||       . |.| .. |. .       ||| . |||
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

AWPDHGVPDHpAPFLQFLRRCRALTP----PESGPVIVHCSAGVGRTGCYIVIDSMLERMKHE--KIIDIYGHVTCLRAQRNYMVQTEDQYIFIH
.| ..  |.  | |. |.   | ..         ||||||| | | || .. .|  .   .     ..|..     ||  |  .. . ..| ||.
swkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1543-1726 1.2e-22 75.1 In-house 4-196 (198) alignment 
Range on Protein: 1543-1726
Range on HMM: 4-196/198.0
NAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR--GTETYGQIFVTITETQELATYSIRTFQLCRQG--FNDRREIKQLQFTA
  |.||| ||.||. |||.| ||  .  |||.   .         ||||   ||  || . ||       . |.| .. |. .       ||| . |||.
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDHpAPFLQFLRRCRALTP----PESGPVIVHCSAGVGRTGCYIVIDSMLERMKHE--KIIDIYGHVTCLRAQRNYMVQTEDQYIFIH
| ..  |.  | |. |.   | ..         ||||||| | | || .. .|  .   .     ..|..     ||  |  .. . ..| ||.
wkekttpnv.alfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1832-2018 1.3e-22 75.0 In-house 5-198 (199) alignment 
Range on Protein: 1832-2018
Range on HMM: 5-198/199.0
SAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQY--YVVDPIAEYNMPQYKLREFKVTDAR--DGSSRTVRQFQFID
  |||.| |....  |||.|.||  |  .||.   .         |||   |   .|    |   .    |.| .  . .|.      |.| . ..||  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEQGVPKSG--EGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRSGVFITLSIVLERM--QYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYR
| |.  |.     ||.    .| |  ||  .| |. |||| | | .|||..| | .         |.|.|.  . ||  |  .. . ..| | |.
wkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1832-2018 1.3e-22 74.9 In-house 4-197 (198) alignment 
Range on Protein: 1832-2018
Range on HMM: 4-197/198.0
SAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQY--YVVDPIAEYNMPQYKLREFKVTDAR--DGSSRTVRQFQFID
  |||.| |....  |||.|.||  |  .||.   .         |||   |   .|    |   .    |.| .  . .|.      |.| . ..||  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEQGVPKSG--EGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRSGVFITLSIVLERM--QYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYR
| |.  |.     ||.    .| |  ||  .| |. |||| | | .|||..| | .         |.|.|.  . ||  |  .. . ..| | |.
wkekttpnvalfvgfvvasrevskkyeq.ekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1916-2025 1.3e-21 71.5 In-house 87-195 (440) alignment 
Range on Protein: 1916-2025
Range on HMM: 87-195/440.0
SSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGqDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHF
 |||..|...  ||..||||     . .| .| ...|. | .||. ||||||.||.|| |..  .|   .    .|.|  .  .|..|| |||| .|| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag.ngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

CYRAALEYLG
 . | || | 
vheavlegll
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1548-1732 1.8e-21 70.9 In-house 96-287 (302) alignment 
Range on Protein: 1548-1732
Range on HMM: 96-287/302.0
TQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR--GTETYGQIFVTIT-ETQELATYS-IRTFQLCRQG-------FNDRREIKQLQF
   | ..|   .| .  . ..| .| .. . |    || .|. ..  |. ..|.  |.     ..|. ..  ..|.|            . .. .. |.|
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TAWPDHGVPDHPAPFLQFLRRCRALTppesGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEA
.|||||| |... . |. |. | .        |.|||||||||||  . |   ..  ...|. |.   |. .|. |   ||.|.| |..   .  .
sawpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
fn3 Fibronectin type III domain 423-508 2e-21 69.1 Pfam-A 1-85 (85) alignment 
Range on Protein: 423-508
Range on HMM: 1-85/85.0
SAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYT-TNSNQpeaSWNSQMVDNSE-LTTVSELTPHAIYTVRVQAYTSMGAGPMS
|||.|..|.  .|......|.||....|..|||.| |  .....    |... |....   |...|.|.. |..||||..  | || |
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge...ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1791-1880 2.1e-21 71.0 In-house 49-152 (350) alignment 
Range on Protein: 1791-1880
Range on HMM: 49-152/350.0
HKNRLVHILPYESSRVYLT--------PIHGIEGSDYVNASFIDGY----RYRSA--YIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQ
 ||| . ||||| ||| |           | ....||.||...       .  .   |||.|.|.. . .||.... . . .....||.. |...||| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPH
||..
YWqe
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1766-2030 8.9e-21 68.9 In-house 23-282 (312) alignment 
Range on Protein: 1766-2030
Range on HMM: 23-282/312.0
VEFKKLSNVKMDSSkfVTANLPcNKHKNRLVHILPYESSRVYLTpihGIEgSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTK
 |.| . |.  ||   .|| |   |  ||   |  ..  |  |.   | |   |. | |.        ....|||.....  ||..     || ...|. 
keykavgnivsdse..ctaflk.fkdlnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcg

LKEMGREKCFQYWPHE--------RSVRYQYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEqfgqd
. | | ||| .|              |  .|     |      .   | .||     |    . ..|.  ||..|.| | .    ..  |.| |      
fvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....

gPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGSFDNY
 |.  ||||||||.| .. .  ..  ...    .| ..  .|| .|   |..  || .. |. ||.| |   |
.pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1670-1735 1.5e-19 64.1 In-house 2-67 (69) alignment 
Range on Protein: 1670-1735
Range on HMM: 2-67/69.0
IVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIIC
.||||.| |||| .| |   . |.| ||..||.  |  .|  |  ||  | .|||||||. ||.  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1762-2023 1.7e-19 64.4 In-house 26-284 (302) alignment 
Range on Protein: 1762-2023
Range on HMM: 26-284/302.0
SGMEVEFKKLSNVKMDSSKfvTANLPCNKHKNRLVHILPYESSRVYLTpihgIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAA---EDFWRMLWEHNST
. .. ||||....|.|  |        | .||.  ..  ..| .| |.     |  .||||| ..    .   | || |..| .   |.|||| .... .
aevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

IVVMLTKLKEMGReKCFQYWPHErSVRYQYYVVDPIAEYNMP---QYKlREFKVTDARDGSSRTVR-QF-QFIDWPEQGVPKSGEGFIDFIGQVhkTKEQ
 ||.| . .|. .    ...|.. |  |..|    .     .   . |  .. .    .| | .|  .   .  |... ||..    |  . .|   ...
svvilvgeeelkk.tlselfpkk.sgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv..fakk

FGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY
   | .. .    |.|| |.|.|| ...|..| .    . ..|. .|||||..|.. .|| . |.|.| |
ikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiallly
fn3 Fibronectin type III domain 714-803 2.3e-19 62.5 Pfam-A 2-85 (85) alignment 
Range on Protein: 714-803
Range on HMM: 2-85/85.0
DPQDVKATPLNSTSIHVSWKPPLekDRNGIIRGYHIHAQELRDEGkgflnEPFKFDVVDTL-EFNVTGLQPDTKYSIQVAALTRKGDGDRS
 |....... .|||...||.||   |..| | || .. .| ....     |.  |.|  |  ....|||.|.|.|...|.|....| | .|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekggge.....ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1670-1735 5.5e-19 62.3 In-house 1-66 (69) alignment 
Range on Protein: 1670-1735
Range on HMM: 1-66/69.0
IVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIIC
.||||.| |||| .| |   . |.| ||..||.  |  .|  |  ||  |..|.|||||. ||.  
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
fn3 Fibronectin type III domain 521-601 9e-19 60.6 Pfam-A 1-83 (85) alignment 
Range on Protein: 521-601
Range on HMM: 1-83/85.0
SQPSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTYANQ-AHHKRISNSE-AYTLDGLYPDTLYYIWLAARSQRGEGA
|.|.|........| .||.|..|.. ...|..||. . ..  ..  .........  .|| || |.| | ....|... ||| 
saPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1547-1694 2.5e-18 61.1 In-house 39-176 (255) alignment 
Range on Protein: 1547-1694
Range on HMM: 39-176/255.0
AtqgplqeTFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQGF--NDRREIKQLQFTAWPDHGV
        |   |...    || ..||.. ..| .. ||..|.|.   |      |..| |.  |   .|| ..  .       ...|  ... |...  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PDHPAPFLQFLRRCRaltppESGPVIVHCSAGVGRTGCYIVIDSMLERMK
|. .   |. |.  |     .| .|.||||.|.||.  .......  .| 
Pelareilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmi
fn3 Fibronectin type III domain 324-404 5.3e-18 58.1 Pfam-A 2-85 (85) alignment 
Range on Protein: 324-404
Range on HMM: 2-85/85.0
APTDVQISEVTATSVRLEWSYK--GPEDLQYYVIQYKPKNANQ-AFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPS
||.....||||.||..|.||    | .....| ..|..|. ..   .      |. .... | |.||||| | |||. | ||.|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
I-set Immunoglobulin I-set domain 140-223 5.5e-18 56.5 Pfam-A 1-87 (90) alignment 
Range on Protein: 140-223
Range on HMM: 1-87/90.0
PVITQGPGTRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDMSN---PRYSLKDGFLQIENSREEDQGKYECVAENSMGTEHSKAT
|..|| .   ....| .| ..|.. |.|.|.. | |.....  |.    ... ..  | |.| ...|.|||.|.|.||.|.. .||.
pkftqklkdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakae
I-set Immunoglobulin I-set domain 36-129 7.9e-18 56.1 Pfam-A 1-90 (90) alignment 
Range on Protein: 36-129
Range on HMM: 1-90/90.0
PEIIRKPQNQGVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGtQSRYTVLEQPgGISILRIEPVRAgRDDAPYECVAENGvGDAVSADATLTI
|.. .|.... |..|  ... | ..|.|.||. | |.|....  ..|..| ..  ... |.|. |.. .|  .|.|.|.|     ..|.|.|..
pkftqklkdvevseGesvelectveGepepsvsWakdgselks.sqrvkvtvee.aeytLtIsnvev.sDeGkYtckatns.agkaeakaeLkV
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1456-1550 3.8e-17 56.2 In-house 4-95 (95) alignment 
Range on Protein: 1456-1550
Range on HMM: 4-95/95.0
PIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVegvVGSDYINANYCDGYRKHNAYVATQG
|| .| |  |.  ..|| .|.| .|. ||      ..     | |  |||. |.  || .|| | .      |||||| . ||| ..|.|.|.||
pihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaqg
fn3 Fibronectin type III domain 915-998 6.2e-17 54.7 Pfam-A 2-85 (85) alignment 
Range on Protein: 915-998
Range on HMM: 2-85/85.0
PPSNITIRFQTPDVLCVTWDPPTreHRNGIITRYDVQFhKKIDHGL-GSERNMTLRK--AVFTNLEENTEYIFRVRAYTKQGAGPFS
.|.|.... .|.. | ..|.||.  ...| ||.|.|.. .. ..|    |.. .  .  ...|.|...||| |||.|....| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYevey.rekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1946-2022 9.7e-17 55.7 In-house 217-293 (297) alignment 
Range on Protein: 1946-2022
Range on HMM: 217-293/297.0
QVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALE
|.   . .  .. .. |||||||||||| .   ..|.... . . ||   ..|||.||. .||| .|....| |.|.
qleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1839-2014 2e-16 54.3 In-house 98-278 (302) alignment 
Range on Protein: 1839-2014
Range on HMM: 98-278/302.0
GPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHE--RSVRYQYYVVDPIA-EYNMPQY------KLR--EFKVTDARDGSSRTVRQFQFID
 | ... | .| .. ..| .||| |....| . .|| .|. ..    .... | |  .  . .. ..      ||   |.| .  ..   .||  ..|  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPEQGVPKSGEGFIDFIgqvhKTKEQFGQDgpITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYH
||. | ||  .  .| .    |  | . ..  . |||||||||.| ....   ..  . . | |. . |  .|. |   ||.|.|  
wpdhGapkeaytaldil....kfcesykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1844-2024 8.6e-16 52.8 In-house 40-221 (255) alignment 
Range on Protein: 1844-2024
Range on HMM: 40-221/255.0
AAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDARD--GSSRTVRQFQFIDWPEQGVPKSGEGFI
. . |....   ... ||||. ..| |.||| .|.| |.  . ..  |. ..  .. .  ||  ..|         .||. ...  |.|.  |.  .   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DFIGQVHKTKeqfgqdgPITVHCSAGVGRSGVFITLSIVLERMQ------YEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
  .  |...|       .. ||||.|.|||  |.   .|  .|         . ||  . .. |||.|.. ..|  |  |.    |...
nilkvvrdsk.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1630-1730 9.2e-16 52.5 In-house 216-341 (350) alignment 
Range on Protein: 1630-1730
Range on HMM: 216-341/350.0
EIKQLQFTAWPDHGVPDHPAPFLQFLR--------RC--RALTPPESGPVIVHCSAGVGRTGCYIVIDSMLE----------RMKH----EKIID-IYGH
.. |||.  |.| ..  .|  .|| |          .    |   .| |..||||||||||| .. .||.|.          ....     |. | |   
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

VTCLRAQRNYMVQTEDQYIFIHDAIL
|  || ||  |||. ||.|||..|.|
vnelrkqrismvqnldqfifiYeall
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1471-1731 1.3e-15 51.6 In-house 22-283 (302) alignment 
Range on Protein: 1471-1731
Range on HMM: 22-283/302.0
SNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEgvvgSDYINANYCDGYRKHNAYVATQGPLQETF---VDFWRMCWELK
| |...  .|...|.  .  .   .   .| .||.  .| ..|. .|.|.| .     .|.||   .    ..  . .| | ...     .|||| .. |
sldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqek

TATIVMMTRLEERTRiKCDQYWP-T-RGTETYGQIFVTITETQELATYS-IRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPP
 ...|.. . || ..   ....| .    ..||..|| .   ..        .  .  .|. .   ..   .| |... ||.. |   .      |.. .
ivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkik

ESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILE
 . ....    |.|| |  ..    .|.....|   |   |. .|.||  .|.. .||.... |.| 
adentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll
subfamily_CG42327_pd Subfamily CG42327 1956-2023 2.6e-15 50.9 In-house 246-314 (319) alignment 
Range on Protein: 1956-2023
Range on HMM: 246-314/319.0
QDGPITVHCSAGVGRSGVFITLSIVLERMQYE-GVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY
. ||..|||| ||||.|. |.  | .....     .|. |.|  .| .|   |.| .|| | |. . ||
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1484-1644 3.1e-15 50.5 In-house 81-235 (244) alignment 
Range on Protein: 1484-1644
Range on HMM: 81-235/244.0
IEPGQQFTWDNSNlEHNKSKNRYANVTAYDHSRVQLpaVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERtri
| |      |  |   |  ||| .    .| .|| |   .| .|  |||| .     .   |. || || .| .|||.|  | .   .|..  .||    
irpdpsvmkdafn.pnnswknregaglpfdfnrvpl..skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee...

kcDQYWPTR-GTETYG-QIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGV
  |.|||     | |  .| ||.|. .|.       ...  .  .  . .  .| . ||  | 
..deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1920-2023 3.1e-15 50.7 In-house 217-343 (350) alignment 
Range on Protein: 1920-2023
Range on HMM: 217-343/350.0
VRQFQFIDWPEQGVPKSGEGFIDFIG--------QVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLE-------------RMQYEG-VLD-VFQTV
| |.|.  |.. ..    | ..  .          . ..  .  .  || ||||||||| |...||  .|.             ....   . | ....|
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

RILRSQRPAMVQTEDQYHFCYRAALEY
 .||.||  |||. ||. |.| |.| |
nelrkqrismvqnldqfifiYeallfy
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1663-1733 3.6e-15 50.6 In-house 225-295 (297) alignment 
Range on Protein: 1663-1733
Range on HMM: 225-295/297.0
PPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAI
 | . ...|||||||||.|  .  | .|.......| |.   .. || ||  .||| .|. ...||.|. .
mprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_hpo-7_pd Subfamily hpo-7 1545-1693 9.5e-15 49.2 In-house 40-181 (263) alignment 
Range on Protein: 1545-1693
Range on HMM: 40-181/263.0
YVAtqgpLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQG--FNDRREIKQLQFTAWPDH
|.     | .|   |...    || ..||..  .|  . ||..|.|.   |      |... |.      ..| .|  .       ...|. ... |...
ysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiek

GVPDHPAPFLQFLRRCRaltppESGPVIVHCSAGVGRTGCYIVIDSMLERM
  |  .   |. |.  |     .| ...||||.|.||.  . |....  .|
ndpelareilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkm
fn3 Fibronectin type III domain 616-700 2.7e-14 46.3 Pfam-A 2-85 (85) alignment 
Range on Protein: 616-700
Range on HMM: 2-85/85.0
PPRNITAIATSSTTISLSWLPPPveRSNGRIIYYKVFFVEVGRED-DEATTMTLNMTSIVLDELKRWTEYKIWVLAGTSVGDGPRS
.|.|.......||...||| ||.    .| | .|.| . |.| .. .   | . . || .| .||  |||...| | . .| ||.|
aPenlsvsevtstsltlsWsppk..dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1774-1933 4.8e-14 46.6 In-house 81-235 (244) alignment 
Range on Protein: 1774-1933
Range on HMM: 81-235/244.0
VKMDSSKFVTANLPCNKHKNRLVHILPYESSRVYLTpiHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGrek
.. | | .  |  | | .|||    ||.. .|| |.  .|  |  |.||||.      . || .| |. |.. |||.|. |    ..|.|  ..|     
irpdpsvmkdafnpnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed...

cfQYWPHERSVRY-QYYV-VDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGV
  .|||    . . .  . |      .. . |  ....    . | ...  ||  .|| .| 
..eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1495-1734 5.3e-14 46.5 In-house 42-280 (303) alignment 
Range on Protein: 1495-1734
Range on HMM: 42-280/303.0
SNLEHNKSKNRYANVTAYDHSRVQLpavegvVGSDYINANYCDGYRKHNAyVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR-G
 .. .|  |||...|   |||.|.|        | || |.| .   ...| . || ||. |  |||.|  | |   ....    |  ..  |  .|    
nqfvknmdknrfvdvicldhskvkl......sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

TETYGQIFVTITETQELATYSIRTFQLCRQGFNDRR-EIKQLQFTAWPDHGVPDHPAP-FLQFLRRCRAL-T-PPESGPVIVHCSAGVGRTGCYIVIDSM
   . . .. . | ...      ....      | .  ..  .. |||   .| . .| |.. . . ...     .| | .    .|.||.| . .... 
flkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

LERMKHEK-IIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAII
   .. |.  .|.   .  .|  | . ||   |. ...  . | ..
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1788-1873 7.7e-14 45.9 In-house 33-117 (332) alignment 
Range on Protein: 1788-1873
Range on HMM: 33-117/332.0
CNKHKNRLVHILPYESSRVYLTPIHGIEgsDYVNASFIDGYRYRSAYIAAQGPVQDAAED-FWRMLWEHNSTIVVMLTKLKEMGREK
 |   ||. |.  .. ||| |.|  | .  |. |||..|||  .|||| || |..| .|  ||||. |.. ......  . |  . |
nnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_CG42327_pd Subfamily CG42327 1664-1728 1e-13 45.7 In-house 245-310 (319) alignment 
Range on Protein: 1664-1728
Range on HMM: 245-310/319.0
PESGPVIVHCSAGVGRTGCYIVIDSMLERMKHE-KIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDA
 . ||..|||| ||||||  |  |  ......  . .||   |  .| .|   |.| .|| ||.  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1537-1620 1.2e-13 45.3 In-house 230-311 (440) alignment 
Range on Protein: 1537-1620
Range on HMM: 230-311/440.0
DGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTrikCDQYWPTRG-TETYGQIFVTITETQELATYSIRTFQL
.|| |.||..||| ||. | .||||.  . . .||.|. .|...|   |  |||    . |.| . |    ....    .||..|
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndkt...csiywpvntrsvtfgpftvghkgsenmnrvkvrtlel
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1497-1730 1.9e-13 45.3 In-house 16-256 (290) alignment 
Range on Protein: 1497-1730
Range on HMM: 16-256/290.0
LEHNKSKNRYaNVTAYDHSRVQLPAVEGVVGSDYINANYCDgYRKHNAYVATQGPLQET-------FVDFWRMCWELKTATIVMMTRLEERTRI----KC
.. .. ..|. .|.   ..|| |        .||| ||.   . .  . ..|| |....         .|| |  . |   .||.   ||...      |
vkkhemdqRl.evpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaC

DQYWPTRGTETYGQIFVTITETQELATYSIRTFQLCRQgFNDRRE--IKQLQFTAWPDHGVPDHPAPFLQFLRRCRAltppESGPVIVHCSAGVGRTGCY
 .| |..  |      .|.  ..  .   . | .|. . |.|..|  ..  ..  | .  |....  .|. ..  .|    .  ||||||  |. |  . 
akYvpesvgeelkfkgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvka....sktpvivHcvdGiSrsAal

IVIDSMLERMK-HEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAIL
  |.     .   .. . .   .  || ||. ..... .. |.  .|.
aaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1961-2023 3e-13 44.0 In-house 2-64 (69) alignment 
Range on Protein: 1961-2023
Range on HMM: 2-64/69.0
TVHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY
 ||||.| ||.| ||.. . . |.. | ..|.|  |. .|  || ||  | .| | . |  | 
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1962-2023 3.2e-13 43.8 In-house 2-63 (69) alignment 
Range on Protein: 1962-2023
Range on HMM: 2-63/69.0
VHCSAGVGRSGVFITLSIVLERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY
||||.| ||.| ||.. . . |.. | ..|.|  |. .|  || ||  |..| | . |  | 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1499-1630 5.2e-13 43.2 In-house 33-159 (332) alignment 
Range on Protein: 1499-1630
Range on HMM: 33-159/332.0
HNKSKNRYANVTAYDHSRVQLPAVEGVvgSDYINANYCDGYRKHNAYVATQGPLQE-TFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTEty
 |   ||   . ..|||||.|   .|    |. ||.. ||| |..||. .| |... |   ||||  | | . |...  ..|. . |.      || |  
nnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfe..

gQIFVTITETQELATYSIRTfQLCRQGFNDRRE
 . |.    .. |    ... ..||. . ..| 
.ksflhefgaksleecelka.kicrkfwpekrs
subfamily_eak_pd Subfamily eak 1789-1943 7.2e-13 42.6 In-house 52-203 (332) alignment 
Range on Protein: 1789-1943
Range on HMM: 52-203/332.0
NKHKNrLVHILPYESSRVYLTPIHgIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHER--SVRY
. ..| .|.|.||.   | ||.    .   |.||| ..       || .  . .|    ||.|. | .|  .|.| .  |.. ||  .|.|..    ...
avnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

QYYVVDPIAEYNMPQYKLREFKVTDARdgSSRTVRQFQFIDWPEQGVPKSgEGFIDF
 .. |.     .  ... | ....      .  |  ...  | |  .||  | |. .
GildverkefvkrniletrllelskGn..ethrvlhykvfGwtettlpky.edflal
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1802-2017 9.4e-13 42.9 In-house 31-252 (290) alignment 
Range on Protein: 1802-2017
Range on HMM: 31-252/290.0
ESSRVYLTPIHGIEGSDYVNASFIDgYRYRSAYIAAQGPVQDA-------AEDFWRMLWEHNSTIVVMLTKLKEMGRE----KCFQYWPHERS--VRYQY
| .|| |        .||. |...  .    . |. | | ..         |.|| |  . ... |||| . .|  ..     | .| |..    .... 
eatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

YVVDPIAEYNMPQYKLREFKVTdARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPITVHCSAGVGRSGVFITLSIVLERMQ-YE
  |      .  . . ||  |.   |.   ||   .. .| .  |...   ... | .|.. |       |. |||  |. || .. .. .    .   .
ltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkask......tpvivHcvdGiSrsAalaaiilgyQkiaets

GVLDVFQTVRILRSQRPAMVQTEDQYHFCY
| . . . .  ||.||  ..... .. |  
gsvkledvlkalrkqralaitsalelafvd
subfamily_hpo-7_pd Subfamily hpo-7 1844-2023 9.4e-13 42.7 In-house 46-226 (263) alignment 
Range on Protein: 1844-2023
Range on HMM: 46-226/263.0
AAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQYYVVDPIAEYNMPQYKLREFKVTDAR--DGSSRTVRQFQFIDWPEQGVPKSGEGFI
. . |....   ... ||||.  .| |.||| .|.| |.  . ..  |.  .   . .  |.  ...         .||.....  |.|.  |.  .  .
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelareil

DFIGQVHKTKEqfgqdgpITVHCSAGVGRSGVFITLSIVLERMQ------YEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEY
  .  . . |.       . ||||.|.|||  |    .|  .|         . ||  . .. |||.|.. ..|  |  |     |..
nilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
Ig_2 Immunoglobulin domain 141-225 1.1e-12 39.8 Pfam-A 3-78 (80) alignment 
Range on Protein: 141-225
Range on HMM: 3-78/80.0
VITqGPGtRVIEVGHTVLMTCKAIGNPTPNIYWIKNQTKVDmSNPRYslkdgFLQiENSREEDQGKYECVAENSMGTEHSKATNL
|..  |   |.. |..| .||.| |||||.. | |. .... ....      ...  |  .||.|.|.|.| || | . |. ...
vls.app.tvvtegenvtLtCqapgnptpkvqwykdgeels.qsqna.....lfi.pnvsaedsGtYtCrasnsegskqsnsvev
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1786-2021 1.3e-12 42.0 In-house 44-276 (303) alignment 
Range on Protein: 1786-2021
Range on HMM: 44-276/303.0
LPCNKHKNRLVHILPYESSRVYLTpihgieGSDYVNASFIDGYRYRSAyIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERS-V
.  | .|||.| ..  . |.| |.       | |. ||...    . | | .| |.. .| |||.|. | .   |..|    |. .      .|...  .
fvknmdknrfvdvicldhskvkls......dssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

RYQYYVVdPIAEYNM-PQYKLREFKVTDARDGSSRTV-RQFQFIDWPEQGVPKSG-EGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVL
...  ..  . |..     .   .||    .|. ..     .. .|| . .|  |   |.  | |.     .. .  |      .|.||.| |  .    
kfeersi.rvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetah

-ERMQYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAAL
    . .  ||. . .  .|  |   ||   |. . |    
lslhseqasldlvkclenvrngrlhavqnlsqfsvvytlla
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1454-1538 3.5e-12 40.4 In-house 3-85 (440) alignment 
Range on Protein: 1454-1538
Range on HMM: 3-85/440.0
HPPIPISEFANHIERlkSNDNQKFSQEYESIEPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDG
. || ...||....   .   . | .|.  .  | .   | ..|  || |||| |. ||||||| |  |.||  |||||| | .|
qrpiivadfadyvqn..nrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1766-1839 3.9e-12 40.2 In-house 27-95 (95) alignment 
Range on Protein: 1766-1839
Range on HMM: 27-95/95.0
VEFKKLSnvkMDS-SKFVTANLPCNKHKNRLVHILPYESSRVYLTPIhgiEGSDYVNASFIDGYRYRSAYIAAQG
 ||| .|   | | . . .    .|  |||.. |.||...|| ||       |||.|| |.|||  . .||||||
nefksis...mtsgapytvgsseanipknrflnifpydatrvvlttk...rdsdyinacfvdgyarkncyiaaqg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1501-1605 4.6e-11 36.6 In-house 49-166 (349) alignment 
Range on Protein: 1501-1605
Range on HMM: 49-166/349.0
KSKNRYANVTAYDHSRVQLPA--------------VEGVVGSDYINANYCDGY--RKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIK
 .|||| ..  |.||||.|.                .. .  |||||||        .. |.||| ||  |  ||...    .   .. ..  .| .  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CDQYWPTrgtETYGQIFVTIT
||.||      .| .| | . 
cdiywqe...lsysnitvklq
fn3 Fibronectin type III domain 1012-1095 1.1e-10 34.7 Pfam-A 2-85 (85) alignment 
Range on Protein: 1012-1095
Range on HMM: 2-85/85.0
APMSLQAEATSEQTAEIWWEPV-TSRGKLLGYKIFYTMTAVEDldDWQTKTVGLTE-SADLVNLEKFAQYAVAIAARFKNGLGRLS
||  |....... .... |.|  . .|.. ||.. | ..  ..  .|...||  |. |. | .|.  ..| . ..|. ..| |. |
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekggge..ewkeftvprtttsvtltgLkpgteYefrVqavngagegpeS
fn3 Fibronectin type III domain 1107-1194 2.4e-10 33.6 Pfam-A 2-80 (85) alignment 
Range on Protein: 1107-1194
Range on HMM: 2-80/85.0
VPLNLRAHDVSTHSMTLSWSPP--IRLTPVNYKISFdamkVFVDSQGfsqtqivPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDY
 | ||....|...|.|||||||   . . ..|.. .      .....       ...|. ..   ...|...| | |.|...| |.  ..
aPenlsvsevtstsltlsWsppkdgggpitgYevey....rekggge.......ewkeftvprtttsvtltgLkpgteYefrVqavngag
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1953-2024 3e-10 33.9 In-house 261-344 (349) alignment 
Range on Protein: 1953-2024
Range on HMM: 261-344/349.0
QFGQDGPITVHCSAGVGRSGVFITLSIVLE----------RMQYEGVL--DVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYL
.  |  .. |||||| ||.||..|| ..|.          ..... .|   .. .| .|| || .|||   |. ..| | |.|.
dtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1630-1731 3.1e-10 33.9 In-house 219-342 (349) alignment 
Range on Protein: 1630-1731
Range on HMM: 219-342/349.0
EIKQLQFTAWPDHGVPDHPAPFLQFLRrCR-----------ALTPPESGPVIVHCSAGVGRTGCYIVIDSMLE--RM--KHEKII--------DIYGHVT
|. |||.  |.| ..   |  .|| |  ..            |   .. ...|||||| |||| .. .|..|.   .  ..   |         |.  | 
ellqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

CLRAQRNYMVQTEDQYIFIHDAILE
 || ||  |||   |.|.|..|.|.
elrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1511-1644 4.2e-10 34.0 In-house 4-126 (130) alignment 
Range on Protein: 1511-1644
Range on HMM: 4-126/130.0
AYDHSRVQlpavegvvGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERtrikcDQYWPTRGT-ETY-GQIFVTITETQ
 .. ||.|        | .||||..     . . |. || || .| .|||.|  |     .|..  .||      |.|||     | |  .| ||.|. .
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrd

ELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGV
|        ..  ..  .  . .  .| . ||  | 
efknikasnleiesdlneshqaltmfqisnwpsdgt
I-set Immunoglobulin I-set domain 234-315 1.4e-09 29.6 Pfam-A 1-87 (90) alignment 
Range on Protein: 234-315
Range on HMM: 1-87/90.0
PTFSRPPeTISEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPENEMPIGRNV------LQLINIQESANYTCIAASTLGQIDSVSV
|.|.... .  ||. |....|.| . |.| |.|.|.|. ..|...... .  .       .. ...... .||| |   .|.  .   
pkftqkl.kdvevseGesvelectveGepepsvsWakdgselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagkaeakae
Ig_3 Immunoglobulin domain 35-115 1.7e-09 29.7 Pfam-A 1-75 (75) alignment 
Range on Protein: 35-115
Range on HMM: 1-75/75.0
PPEIIRKPQNQGVRVGGvASFYCAARGDP-PPSIVWRkngkkVSGTQSRYTVLEQPGGISILRIEPVRaGRDDAPYECVAEN
.|.|. .|..  . .|.  .. | |.| | ||.| |       ...... ..  . .. |.| |..|    |.  |.|||.|
kPvisvspsptvtsggn.vtLtCsaeggpppptisWy.....ietppelqgsegssssestLtissvt.sedsGtYtCvasN
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1791-1880 2.4e-09 31.0 In-house 50-155 (349) alignment 
Range on Protein: 1791-1880
Range on HMM: 50-155/349.0
HKNRLVHILPYESSRVYLT----PIHGIEGS----------DYVNASFIDGYRYR--SAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGREKC
 |||  .||||| ||| |     . ..|. |          ||.|| ..   |.     ||| | |.  . .||....   .  .|. |.. || . |||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

FQYWPH
 .|| .
diywqe
Ig_2 Immunoglobulin domain 234-312 2.9e-09 28.8 Pfam-A 2-73 (80) alignment 
Range on Protein: 234-312
Range on HMM: 2-73/80.0
PTFSRPPetiSEVMLGSNLNLSCIAVGSPMPHVKWMKGSEDLTPEnempigRN--VLQLINIQESANYTCIAASTLGQIDS
|..| ||   ..|  |.|..| | | | | | |.| |..| |..       .|   .....  .| .||| |  . |.. |
pvlsapp...tvvtegenvtLtCqapgnptpkvqwykdgeelsqs......qnalfipnvsaedsGtYtCrasnsegskqs
fn3 Fibronectin type III domain 832-900 3e-09 30.1 Pfam-A 15-84 (85) alignment 
Range on Protein: 832-900
Range on HMM: 15-84/85.0
SIELEWERPAQTYGELRGYRLRWGVKDQA--LKEEMLSGPQMtKKRFDNLERGVEYEFRVAGSNHIGIGQE
|..|.|. |..  |.. ||....  |..    ||  ......    . .|. | ||||||.  |  | |.|
sltlsWsppkdgggpitgYeveyrekgggeewkeftvprttt.svtltgLkpgteYefrVqavngagegpe
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1826-1908 4.6e-09 30.1 In-house 230-310 (440) alignment 
Range on Protein: 1826-1908
Range on HMM: 230-310/440.0
DGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEmgrEKCFQYWPH-ERSVRYQYYVVDPIAEYNMPQYKLREFK
.||  . |.||.| |.. .  ||||.. ... . ..|| .|..     |  |||   ||| .  . |      || . |.| ..
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtle
0038934 (Phosphotyrosine protein) phosphatases II 1924-2019 4.8e-09 31.6 In-house 81-172 (194) alignment 
Range on Protein: 1924-2019
Range on HMM: 81-172/194.0
QFIDWP--EQGVPKSGEGFIDFIGQVHKTKEQfGQDGPITVHCSAGVGRSGVFITLSIVL-ERMqyegvlDVFQTVRILRSQRPAMVQTEDQYHFCYRA
.....|  ..|.. | |   .|.  |..  ..  ..| . ||| ||.||.|...   ..   .|      .. . ....|. || .... |...  .. 
eylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyrlgm......saeeAialfrekRpgaipnqdyleallkr
subfamily_eak_pd Subfamily eak 1503-1647 5.2e-09 29.9 In-house 55-197 (332) alignment 
Range on Protein: 1503-1647
Range on HMM: 55-197/332.0
KNrYANVTAYDHSRVQLPAVEgVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRG--TETYGQI
.|   ..  ||.  |.| .        ||||   .     . |. |  . ..    ||.|  | |. .||..    |    | |.|.| ..     .|..
rn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

FVTITETQELATYSIRTFQLcRQGfNDRREIKQLQFTAWPDHGVPDH
 |.  |  . . .  | ..| ..| |.  ...  ..  | .  .|  
dverkefvkrniletrllel.skG.nethrvlhykvfGwtettlpky
Ig_3 Immunoglobulin domain 140-213 7.2e-09 27.7 Pfam-A 2-75 (75) alignment 
Range on Protein: 140-213
Range on HMM: 2-75/75.0
PVITQGPGTRVIEVGHtVLMTCKAIGNP-TPNIYWIKNQTKVDMSNPRYSLKDGFLQIENSREEDQGKYECVAEN
|||.  |.. |...|  |  || | |.| .|.|.| . .. .. .. . |  .. | |..  .|| | |.|||.|
Pvisvspsptvtsggn.vtLtCsaeggpppptisWyietppelqgsegssssestLtissvtsedsGtYtCvasN
subfamily_eak_pd Subfamily eak 1654-1734 8.4e-09 29.2 In-house 226-306 (332) alignment 
Range on Protein: 1654-1734
Range on HMM: 226-306/332.0
FLRRCrALTPPESGPVIvHCSAGVGRTGCYIVIDsMLERMKHEKIIDIYG---HVTCLRAQRNYMVQTEDQYIFIHDAILEAII
.|..    |||   |.|  .. |  |.| ..||| .| |.  .|. . |     .   . .|.. | .. |. ||....|. . 
tlkky.ihtppsfapii.qsarGsaraGvfvvid.llirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_PTPDC1_pd Subfamily PTPDC1 1948-2017 8.6e-09 30.1 In-house 105-169 (182) alignment 
Range on Protein: 1948-2017
Range on HMM: 105-169/182.0
HKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVlermqYEGVLDVFQTVRILRSQRPAMVQTEDQYHFCY
 |  ..  |.| ..||| || || || |.  .|     |   |.  ......||.||  .|| .| ... 
vkvvafalqegkvavhChaGlGrtGvliacylv.....yakrltaekaiklvrskrpksiqtreqvelvk
Ig_2 Immunoglobulin domain 41-129 1e-08 27.1 Pfam-A 6-80 (80) alignment 
Range on Protein: 41-129
Range on HMM: 6-80/80.0
KPQnQGVRVGGVASFYCAARGDPPPSIVWRKNGKKVSGTQSRytvleqpggiS-ILRiepVRAGrDDAPYECVAENGVGDAVSADATLTI
 |. . |. |    . |.|.|.|.|.. |.|.|...| .|..          . |     | |  |   |.|.| |. | ..|   ..|.
app.tvvtegenvtLtCqapgnptpkvqwykdgeelsqsqna..........lfipn...vsae.dsGtYtCrasnsegskqsnsvevtv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1783-1831 1.1e-08 28.9 In-house 41-89 (440) alignment 
Range on Protein: 1783-1831
Range on HMM: 41-89/440.0
TANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYR
 |.|| || |||   || |. ||| |  ..|.  |||.|||.|.|   |
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesr
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1799-1932 1.1e-08 29.4 In-house 3-125 (130) alignment 
Range on Protein: 1799-1932
Range on HMM: 3-125/130.0
LPYESSRVYltpihgieGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEMGrekcfQYWPHERSVR-YQYYVVDPIAEY
|..| ||.         | .|.||||.      . |. .| |. |.. |||.|. |    ..|.|  ..|       .|||    .  |.  ..  ... 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpdsePlewyeediivtltdr

N-MPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQG
. . . |  .... .    | ...  ||  .|| .|
defknikasnleiesdlneshqaltmfqisnwpsdg
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1777-1882 6.5e-08 25.7 In-house 15-88 (169) alignment 
Range on Protein: 1777-1882
Range on HMM: 15-88/169.0
DSSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNAsfidgyryrsayiaaqgpvqdaaedfwRMLWEHNSTIVVMLTKLKEmgrekCFQ
   . . |.| ||. |||    |     || |  .    ||||.||                           ||.|| |....|.|    .       .
ieynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtdd.....knn

YWPHER
.||   
fwpeke
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1495-1582 8.2e-08 25.3 In-house 22-82 (169) alignment 
Range on Protein: 1495-1582
Range on HMM: 22-82/169.0
SNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINAnycdgyrkhnayvatqgplqetfvdfwRMCWELKTATIVMMTRLEERTR
..|  |..||| |   |  | ||.|  |   .|||||||                           || ||  .. ||..   ...  
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknn
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1778-1882 8.8e-08 25.2 In-house 15-87 (169) alignment 
Range on Protein: 1778-1882
Range on HMM: 15-87/169.0
SSKFVTANLPCNKHKNRLVHILPYESSRVYLTPIHGIEGSDYVNAsfidgyryrsayiaaqgpvqdaaedfwRMLWEHNSTIVVMLTKLKEmgrekCFQY
  . . |.| ||. |||    |     || |  .    ||||.||                           ||.|| |....|.|    .       ..
eynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtdd.....knnf

WPHER
||   
wpeke
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1495-1582 9.4e-08 25.1 In-house 21-81 (169) alignment 
Range on Protein: 1495-1582
Range on HMM: 21-81/169.0
SNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINAnycdgyrkhnayvatqgplqetfvdfwRMCWELKTATIVMMTRLEERTR
..|  |..||| |   |  | ||.|  |   .|||||||                           || ||  .. ||..   ...  
aeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknn
V-set Immunoglobulin V-set domain 144-227 2.7e-07 21.4 Pfam-A 6-114 (114) alignment 
Range on Protein: 144-227
Range on HMM: 6-114/114.0
QGPGTRVIEVGHTVLMTCKAI-GNPTPNIYWIKNQT---KV----------------DMSNPRYSLKDGF-----LQIENSREEDQGKYECVAENSMGTE
| |.  . ..| .|...|.    . . .|||.| .|   ..                  |. .   ..|      |.| | | ||.| | | ...| . .
qsprpvtvaeGgsvtLpCfysssensqsiyWykqktgskpeliiryvaetnnskvgesfsgrvtlssngsksdfsLtiqnlrleDsGtYtCavsdsnedv

HSKATNLYV
  . |.|.|
fgagtrltV
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1495-1574 3.6e-07 24.0 In-house 32-116 (347) alignment 
Range on Protein: 1495-1574
Range on HMM: 32-116/347.0
SNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVG-----SDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMM
.. |.. ||||  .|   | .|| |   .   .       |||| .      .. |. || || .|  |||.|   .| . .| .
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
0038934 (Phosphotyrosine protein) phosphatases II 1638-1686 1.2e-06 23.9 In-house 86-135 (194) alignment 
Range on Protein: 1638-1686
Range on HMM: 86-135/194.0
AWPDHGVPDHPAPFLQFLRRCRALTPP-ESGPVIVHCSAGVGRTGCYIVI
 .||.|..   .  |.||. .   .   ..| | ||| ||.||||. .. 
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
ig Immunoglobulin domain 154-211 1.6e-06 19.4 Pfam-A 1-64 (64) alignment 
Range on Protein: 154-211
Range on HMM: 1-64/64.0
GHTVLMTCKA-IGNPTPNIYWIKNQTKVDMSNPRYSLKDGF-----LQIENSREEDQGKYECVA
| .| .|| .  |.| ....|.|...    |.. ..  ..      |.| |  .|| | |.||.
GssvtLtCsvssgppstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCvv
PTPc_motif_SM00404 1915-2009 2e-06 22.8 In-house 44-127 (140) alignment 
Range on Protein: 1915-2009
Range on HMM: 44-127/140.0
GSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVhktkeqFGQDGPITVHCSAGVGRSGVFItlsiVLERMQYEGvLDVFQTVRILRSQRPAMVQT
 |.... | .  |  .. . |  .  .||| ..        . | . ||| ||| ||. .|    . . |.|.. |.. . .......||.. ..
nsgfqilqiplddnekdklskyldkvldfiena......ekkggkvlVHCqaGvSRSatli....iaYlmryrq.lslaeayefvkerRpiispn
subfamily_DSP19_pd Subfamily DSP19 1920-2005 9.3e-06 20.1 In-house 58-132 (152) alignment 
Range on Protein: 1920-2005
Range on HMM: 58-132/152.0
VRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKeqfgqdGPITVHCSAGVGRSGVfITLSIVLERMQyegvLDVFQTVRILRSQRPA
. . . .| ||. . .  .  .||| ......      | . |||.||| ||   . .. .... .    |.. .... .|..||.
ylsieilDlpetdllsylkealdFieearskd......gavlvHCnAGvSRsas.vviaylmkkee....lsleealelvrearpc