Gene IA-2 in Drosophila melanogaster

Synonym: CG11344, CG31795, CG4355, Dmel\CG31795, R-PTPX/1A2, anon-WO0153538.69, ia2, Dmel_CG31795, IA-2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRN
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP051_AA protein Get Run
DmelP051_AA_944-1223 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRN_pd Subfamily PTPRN 930-1227 2.2e-169 556.7 In-house 1-297 (297) alignment 
Range on Protein: 930-1227
Range on HMM: 1-297/297.0
SEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAP
||||...|.||||||.||||.||||.|| ||..||||||.||||||..|.|......  ||  | |||||||| |.. |.||  ||.|||.|.|||||||
seepvvsnldistGhvvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap

AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHM
||.|.||||.||.|.||||.||||.||||.|.||.|.|  .|.||||.||.||||||||||||||||||||||||||||||.||||||||||||||||..
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpee

GVPAQAKALLDFRRKVNKSYRGrRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILK
||||.||.||.||||||||||| ||||||||.|.||||||||||.||||.|..||..|||||||||||||||.|.|.|..||||.|.||||||.||||
gvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnailk
subfamily_PTPRD_pd Subfamily PTPRD 955-1257 5.9e-83 274.4 In-house 20-314 (564) alignment 
Range on Protein: 955-1257
Range on HMM: 20-314/564.0
RNKGRLQREWEALCRYeaEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGA
 .. ....|.. . .   . .  |||..|.    ||    ..||||||||... . || ||.||| |  .. .  ||.|.||||..|.. ||.|.|||  
nsdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqns

VVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYrGRRS
 .|| | .|.|.|.| |..||||.| | |  ..| |..|.    || .|.| ||. ..||.|.|.|||| |||. ||| .|..|||..|||...   . .
stiVmltkleEkgkvkchkYWPekgtetygeltVtleeeee.ladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epda

CPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSgeKRELDKDPVVGGGSSSTT
 ||||| ||| ||||..| .| .|||...  . .||  ....|| ||  .| |..|. |.  |..| ...  . .....   |..|.|   |  ....|.
gPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenl..kqhlqkLaeveedtemtg

TKE
 . 
lel
0050432 (Phosphotyrosine protein) phosphatases II 934-1226 2.3e-82 272.1 In-house 19-303 (308) alignment 
Range on Protein: 934-1226
Range on HMM: 19-303/308.0
ALTNMDISTGHMVLSYMEDhLRNKGRLQREWEALCRYEAePSAREAASQPQCAGLNRPGAPLPYDHSRVVLnhlanAEGLDYVNASTITDHD-PRAPAYV
 |...   . . .| ..|. . ..|.|..|.|.|...   .  ...|..|.   .||    ||||||||.|      || ||.||| .. ..  .  ...
ilvsslklsvldllkllek.aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfI

AAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEE---GAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHM
|.|||||.|...||.|.|||.  ||| |..|.||| . ||.|||.|   | ..|. . |.|.||.. .||| || ..|.||...|.||||.||...||..
atqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdh

GVPAQAKALLDFRRKVNKSYrgrRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAIL
||| ....|||| ..|.||.   ...||||| ||| ||||..|.|||.||...|. ...|.  .. .|| ||.|.| | .|..|. .|..| .. .|
gvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 937-1220 1.1e-81 269.8 In-house 2-284 (288) alignment 
Range on Protein: 937-1220
Range on HMM: 2-284/288.0
NMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEpSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQG
...||. ...  ... ..... .|..|.|.|... .    . ||. |.    ||    ||||||||.|..| . || ||.||| | |  ..  ...|.||
dteisveellklvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqg

PLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNL----RTSETRTVTQFHFLSWPHMGVP
|||.|...||.|.|||.  ||| |..|.|.| . ||.|||..| ..|. . |.|.||.. .||| || ....||     ..|.||||.||...||..|||
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

AQAKALLDFRRKVNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
  ...|||| |.|.|...  ...|.||| ||| ||||..|.|||.||...|. ...|.  ....|| || |.| | .|..|| .|..|
dspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0040438 (Phosphotyrosine protein) phosphatases II 944-1227 4.6e-78 258.0 In-house 4-281 (317) alignment 
Range on Protein: 944-1227
Range on HMM: 4-281/317.0
HMVLSYMEDHLRNKGRLQREWEALCRYEAEpsAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLA
...| ..  .......|..|.| |...  .   .. |. |.  ..||    ||||||||.|..| . ...||.||| . |   . ....|.|||||.|..
dlllalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntve

HFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRR
.||.|.||||  ||| |..| |.| . ||.|||...  .|. . |.|.||.  .... .| . ...|..||.||||.||...||..|||   . |||| .
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfle

KVNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILK
.|..... ....|..|| ||| ||||..|...|.||...|.  ..|.  ....|| ||.|.| | .|..|. .|..| .   |.
avreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
0039614 (Phosphotyrosine protein) phosphatases II 929-1222 5e-78 257.8 In-house 3-289 (297) alignment 
Range on Protein: 929-1222
Range on HMM: 3-289/297.0
WSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEpsaREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANA-EGLDYVNASTITDHDPR
. ....|....|..... | .. ... .|..|..|.| |...  .   .. |  |.   .||    ||||||||.|... .  ...||.||| .. .| .
plrdallesipiplsvldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydll

APAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvACARYWPEEGAeVYHIYEVHLVSEHIwCDDYLVRSFYLKNlrTSETRTVTQFHFLSWP
 ....|.|||||.|...||.|.||||  ||| |..| |.|   ||.||||||  .|. . |.|....  .|.| || . ..|  ..|.||||.|....||
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwp

HMGVPAQAKALLDFRRKVNKSYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
..|||  .. ||.| ..|.. ..   ...|..|| ||| ||||..|...|.||...|. ...|.  ....|| || |.| | .|..|. .|..| .
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallell
0046845 (Phosphotyrosine protein) phosphatases II 960-1225 2.6e-77 255.3 In-house 2-277 (284) alignment 
Range on Protein: 960-1225
Range on HMM: 2-277/284.0
LQREWEALCRYEAEPS-AREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANA-EGLDYVNASTITDHD----PRAPAYVAAQGPLPSTLAHFWQMIWEQG
|..|.|.|...   ..  ...|  |.   .||    ||||||||.|..| .  |. ||.||| .. .|     . ....|.|||||.|...||.|.|||.
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

AVVIVALCRLQENGEVACARYWPEEG-AEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLR-TSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRG
. ||| |..| ||| . ||.|||.||   .|. . |.|.||.. .||| || ..|.||  |.|.||||.||..|||..|||.... ||.| |.|..... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-RRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAR--EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAI
  ...||||| ||| ||||..|.|||.||...|. .  ..|.  .. .||.|| | | | .|..|| .|..| .  .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0047943 (Phosphotyrosine protein) phosphatases II 949-1220 1.5e-76 252.7 In-house 3-270 (273) alignment 
Range on Protein: 949-1220
Range on HMM: 3-270/273.0
YMEDHLRNKGRLQREWEALCRYEAePSAREAASQPQCAGLNRPGAPLPYDHSRVVLnhlaNAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQM
.. ..| ....|..|.|.|...   .  ...|. |.   .||    ||||||||.|    . .| ||.||| . |  .. ....|.|||||.|...||.|
lllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrm

IWEQGAVVIVALCRLQENGEVACARYWPEEG---AEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV
.|||.. ||| |..|.|.| . ||.|||.||    ..|. . |.|.||.. .||| || ..|.|| |.|.||||.||...|| .|||.. . ||.| ..|
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

NKSYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
.| ..   .. |.||| ||| ||||..|.|||.|....|. ...|.  .. .||.|| |.| | .|..|. .|..|
rkalealpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealle
0043336 (Phosphotyrosine protein) phosphatases II 940-1220 9.2e-76 250.2 In-house 2-275 (278) alignment 
Range on Protein: 940-1220
Range on HMM: 2-275/278.0
ISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAepSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLP
||. ...  ..| .| .| .|..|.| |...      .. |  |.   .||    ||||||||.|..| . ...||.|||.. |  .. ....|.|||||
isvkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlp

STLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPeEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALL
.|...||.|.||.|  .|| |..| |.| | ||.||| .| ..|. . |.|..|.  .||| || . ..||...|.||||..|.|.||..||| . . ||
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

DFRRKVNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
|| ..|.. ..  .. |..|| ||| ||||..|.|.|.||...|.  ..|.  ....|| ||.| | | .|..|. .|..|
dflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 938-1220 4.2e-74 245.3 In-house 7-302 (307) alignment 
Range on Protein: 938-1220
Range on HMM: 7-302/307.0
MDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAE-PSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANA-EGLDYVNASTITDHDP-------RA
. |.. ...| .....| .. .|..|.| |.... . .  ...|. |.   .||    |||||.||.|..| .  |. ||.||| ......       . 
lfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlk

PAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAE-VYHIYEVHLVSEHIwCDDYLVRSFYLKNL-RTSETRTVTQFHFLSW
 ...|.|||||.|...||.|.||||  ||| |..| |.| . ||.|||.|| | .|. . |.|.||.. .|.| || . ...|  |.|.||||.||...|
rkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgw

PHMGVPAQAKALLDFRRKVNKSYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGARE--IDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
|..|||   . |||| ..|.| ..   ...|..|| ||| ||||..|...|.|....|.     .|.  ....||.|| |.| . .|..|. .|..|
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 951-1221 8.5e-74 243.8 In-house 6-276 (297) alignment 
Range on Protein: 951-1221
Range on HMM: 6-276/297.0
EDHLRNKGRLQREWEALCRYEAEPSaREAASQPQCAGLNRPGAPLPYDHSRVVLnhlaNAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIW
 ..| .. .|..|.| |... . .| ...|. |.   .||    |||||.||.|    . || ||.||| . |   .  ...|.|||||.|...||.|.|
lekllflalllkefeellpllllgs.lsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvw

EQGAVVIVALCRLQENGEVACARYWPEE--GAEVYHIYEVHLVSEHIW-CDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK
||.  ||| |..| |.| . ||.|||.|  .  .|. . |.|.|.... .||| .| . .......|.||||.||...||..|||  .. |||| ..|.|
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

SYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNK--GAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
 ..   .. |..|| ||| ||.|..|..||.|.....    ...||  .. .||.||.|.| | .|..|. .|..| 
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 957-1231 1.8e-71 235.8 In-house 17-289 (318) alignment 
Range on Protein: 957-1231
Range on HMM: 17-289/318.0
KG--RLQREWEALCRYEAEPSAREAaSQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGA
.|   |..|.|.| | |..... ..  .|  .  ||    |.|||.|| |..|.. || ||.||. | |   |  ||.|||.||| |.  ||.|.|||..
sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi.dGyrrkkayiaaqaPlpetieDfWrmvWeqns

VVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSeHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRS
 ||| | ...|.| . ..||||..|.. |    |.| . .. ..||..|.| ...  ..|.|.| |.|. |||  |||...  |||. |.|.|  .    
avivmltqeeergkakvhryWPskgsrsygklvvelke.evelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksga

CPIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPA
 ||||| ||| |||||.| .| .|||... |  .|.  | ..||.||  .| |..|.||.  .. | ...  .   |
gpivvhCsaGvGrtGvfiavdillerikaea.lvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevda
DSPc_SM00195 961-1221 1.8e-70 232.7 In-house 3-261 (263) alignment 
Range on Protein: 961-1221
Range on HMM: 3-261/263.0
QREWEALCRYEAEPsAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHdPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVAL
..| | | ... .    . | ...    ||    |||||.|| |..  . || ||.||. |. .  .  .|.|.|||||||...||.|.||..  .|| |
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

CRLQENGEVACARYWPEE--GAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRrSCPIV
.. .|||.  |.||||||  | |... ..|.||....  |.. .| . |..  ..|||.|||... .||. ||| ..| .|.. |.|.||..   | |||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHGSAGAGRTGVYILLDLVLERMNKGAReIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
|| ||| ||||.....|..|...... . .|| .....||.||.|.| |..|. |. .|..| 
VhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 961-1221 1.8e-70 232.7 In-house 3-261 (263) alignment 
Range on Protein: 961-1221
Range on HMM: 3-261/263.0
QREWEALCRYEAEPsAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHdPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVAL
..| | | ... .    . | ...    ||    |||||.|| |..  . || ||.||. |. .  .  .|.|.|||||||...||.|.||..  .|| |
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

CRLQENGEVACARYWPEE--GAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRrSCPIV
.. .|||.  |.||||||  | |... ..|.||....  |.. .| . |..  ..|||.|||... .||. ||| ..| .|.. |.|.||..   | |||
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHGSAGAGRTGVYILLDLVLERMNKGAReIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
|| ||| ||||.....|..|...... . .|| .....||.||.|.| |..|. |. .|..| 
VhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
0045098 (Phosphotyrosine protein) phosphatases II 973-1223 4.3e-68 225.0 In-house 21-273 (278) alignment 
Range on Protein: 973-1223
Range on HMM: 21-273/278.0
EPSAREAASQPQCAGLNRPGAPLPYDHSRVVlnhlanaeglDYVNASTITDHdPraPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACA
 ||  . |  . .. .||    ||||||||.          ||.||| |. . |  ....|.|||||||.|.||.|.||.|  ||| |..|.|.| . ||
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

RYWPEEGAEVYHIYEVHLVSEHIWcDDYLVRSFYLKNL----RTSETRTVTQFHFLSWPHMGVPAQA--KALLDFRRKVNKSYR------------GRRS
.||||.| ..|. ..|.|.||... ||| .| ... ||     . |.|.||..|.|.|| .||| .   | .|.. . ... ..              ..
qywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg

CPIVVHGSAGAGRTGVYILLDLVLERMnkGaREIDIAATLEHLRDQRAG-VVATRQQFEFVLMAVAEEVH
.|..|| ||| ||||......|.||..  . . .|.  ....|| || | .| . .|..|. ....| ..
gpvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllelll
Y_phosphatase Protein-tyrosine phosphatase 989-1220 1.8e-67 222.6 Pfam-A 5-235 (235) alignment 
Range on Protein: 989-1220
Range on HMM: 5-235/235.0
NRPGAPLPYDHSRVVLNHLANAEGldYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWP--EEGAEVYHIY
||    ||||..|| |..  ...   |.||.... .. .  ...|.||||.||...||.|.|..   ||| |..|.|.|...||.|||  ||. . |. .
nRykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

EVHLV-SEHIWCDDYLVRSFYLKNLRTS-ETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYrGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKG
.|.|. .|. ....| .| . ||.  .. |.|.|.|.|. .||. |||...|.|||. |||.||    .| |.||| |||.||||....||..||.....
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

AReIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
   .|.  ....|| ||.|.| . .|..|. .|..|
ee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 989-1220 1.8e-67 222.6 In-house 5-235 (235) alignment 
Range on Protein: 989-1220
Range on HMM: 5-235/235.0
NRPGAPLPYDHSRVVLNHLANAEGldYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWP--EEGAEVYHIY
||    ||||..|| |..  ...   |.||.... .. .  ...|.||||.||...||.|.|..   ||| |..|.|.|...||.|||  ||. . |. .
nRykdilpydktrvklkgsegpsd..YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

EVHLV-SEHIWCDDYLVRSFYLKNLRTS-ETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYrGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKG
.|.|. .|. ....| .| . ||.  .. |.|.|.|.|. .||. |||...|.|||. |||.||    .| |.||| |||.||||....||..||.....
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleae

AReIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
   .|.  ....|| ||.|.| . .|..|. .|..|
ee.vdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 958-1223 4e-67 221.6 In-house 27-291 (298) alignment 
Range on Protein: 958-1223
Range on HMM: 27-291/298.0
GRLQREWEALCRYEA--EPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFWQMIWEQGAV
 ... |.. | . .   |    |.|..|.    ||    ...|.|||||..  . |  ||.||| .  .. |  |..|.|.||..|.. ||.|..|. . 
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedig

VIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCdDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSC
.|| |  |.| ... . .|||.||.| |   .|.| |..    |. || . ... .....|.| |.|| |||  |||..|...||..|||..| .     
tiVmltnleeldktkyhkywPdegketygeitvsllskeefa.dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnk

PIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
|..|. ||| ||.| .| .| ||||..|  . .|.  ... || .|.|.| |..|. |. .|| | ..
pvivqCsaGvgRsGtfiaidsvlervkk.eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPN12_pd Subfamily PTPN12 971-1230 4.5e-67 221.0 In-house 25-285 (290) alignment 
Range on Protein: 971-1230
Range on HMM: 25-285/290.0
EAEP-SAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEV
 ||    .||.....    ||    ||||.|||.|..  . || ||.||. |   .    .|.||||||| ||  ||.||||.   ..| .||. |.|  
kaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgve.gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

ACARYWPEEGAE-V-YHIYEVHLVSEHIWCDDYLVRSFYLKNLrtSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKsYRGRRSCPIVVHGSAGAGR
 |.||||||| | . .  .|| | .|.   ||.|.|.. ...   .|.|.|.|||. .||  |||..|| ||.. ..|.. .. . . |.||| ||| ||
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvre.lqesedaPlvvhCsaGvGr

TGVYILLDLVLERMNKGAR--EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALP
||. | .|.| | ....    |.|.   . .|| ||| .| |..|.|.| .|||| |.. |....
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiie
0040439 (Phosphotyrosine protein) phosphatases II 986-1220 2e-66 219.5 In-house 12-244 (249) alignment 
Range on Protein: 986-1220
Range on HMM: 12-244/249.0
AGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHI
  .||    ||||||||.|..| . .. ||.||| | |   . ....|.|||||.|...||.|.||.|  ||| |..|.|.| . ||.|||..|  .|. 
kdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygd

YEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNKG
. |.|.|... .||| || ..|.|| ..|.|||.......||..|||   . |||| ..|.| ..   ...|..|| ||| ||||..|...|.||...| 
ftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqleke

aREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
 ...|.  ....||.|| |.| . .|..|...|..|
.lgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_PTPRB_pd Subfamily PTPRB 949-1220 2.4e-66 218.7 In-house 16-283 (293) alignment 
Range on Protein: 949-1220
Range on HMM: 16-283/293.0
YMEDHLRNKGRLQREWEALCRYEAEPSaREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFWQM
... . ... |.. |.| |   . . .  .||.... .  ||    |||||||| |..|.. .| ||.||. | ..  .   ..|.|||||.|. .||.|
vkkmkadsdlrfseeyeelkavgkdqa.vkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspr.efiatqGPlpetvddfWrm

IWEQGAVVIVALCRLQENGEVACARYWPEE-GAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNlrTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK
.||. . .|| | .| |.| | | .|||..  . .|   .|.||.|.   .|. .|.. ...  ..|.|.|.|.||.|||  ||| ..|.|||| |.|..
vwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeee.ledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvre

SY-RGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
.  .  .. ||||| ||| ||||..| || .|.....    .||.... .|| .|. .| | .|. |.  .| .
aiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvld
0042113 (Phosphotyrosine protein) phosphatases II 987-1220 4.2e-66 218.1 In-house 11-241 (245) alignment 
Range on Protein: 987-1220
Range on HMM: 11-241/245.0
GLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIY
 .||   .|||||.||.|..  . ...||.||| . | . . | . |.|||||.|...||.|.||.|  .|| |... |.| | ||.|||...  .|. .
dknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdf

EVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaR
 |.|.||.. .||| || . ..||...|.|.|...|.|.||..|||   . |||| . |.| ..  .. |..|| ||| ||||..|...|.||...|  .
tvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqleke.l

EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
....  ....||.|| |.| | .|..|. .|..|
gvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 950-1224 1.2e-65 216.7 In-house 15-285 (319) alignment 
Range on Protein: 950-1224
Range on HMM: 15-285/319.0
MEDHLRNKGRLQREWEALCryEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFWQMI
.. .   .  |..|.. |   ||..   . ||...    ||    |.||..|||| .| . || ||.||| |  .. |  ...|.|.||  |.  ||.|.
kalastgetllekefkllk..eavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqere.kfiatqaPlentiedfWrmv

WEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHiWCDDYLVRSFYLkNLRTSE--TRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK
||... ..| |..|.|...| . .|||||  |.|  . | | .|.   .|| .| . | | ..||  ||.|..|....||  .|| .|..|||. ....|
WeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeee.eledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

SYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
| ..  | ||||| |||.|||| .| || .|||... .  .|.  |  .|| ||  .| . .|..|.  |. | |.|
srektqsgPivvhCsaGvGRtGtfivldamlervkeeg.vlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 955-1225 2.5e-65 215.4 In-house 11-279 (281) alignment 
Range on Protein: 955-1225
Range on HMM: 11-279/281.0
RNK-GRLQREWEALCRYEAEPSArEAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFWQMIWEQG
.|.   ...|.|.|   . . .| .|. ...    ||      ||..||....  ...  ||.||. .   .  . .|.|.|||.|..|..||||.||| 
qndnaGfieeyeklaaigvdnta.taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgek.eyiatqgPvPaslvafWqmvweqk

AVVIVALCRLQENGEVACARYWPEEGAEV-YHIYEVHLVSEHiWCDDYLVRSFYLkNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGR
. .|| . |  |.| . | ||||.. .|. |  . |. ..|.     |. | | | . ...|||.|.|.....||  ||||..|.||.||..|.|  . .
vsaivmvtreieagklkChrYWPddnselkygdvtvkstaee.ekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekk

RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAI
. .|.|.| ||| ||||.|| || ....... ..|.|. |....|| .|  .| |  |.|||  || . ..  
tkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPN6_pd Subfamily PTPN6 949-1222 1.3e-64 213.2 In-house 18-297 (306) alignment 
Range on Protein: 949-1222
Range on HMM: 18-297/306.0
YmEDHLRNKGRLQREWEALCRYEAE-PSAREAASQPQCAGLNRPGAPLPYDHSRVVLNhLANAEGLDYVNASTITD-HDPRAPAYVAAQGPLPSTLAHFW
  |..  .|  .. |.|.| . ||.    |. ...|. .  ||  . ||.||.||.|.   .  | ||.||. |..       .|.|.|| |..|.. ||
k.eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFW

QMIWEQGAVVIVALCRLQENGEVACARYWPEEGAE-VYHIYEVHLVSEhIWCDDYLVRSFYLK-NLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRK
.|.|.. . ||| . .  | |.  ||||||.| ..  |  ..|. |||    .|| .|.. .. . . .|.|.| |.|| |||  |||.. .|.||| ..
rmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfled

VNKSYRGRR---SCPIVVHGSAGAGRTGVYILLDLVLERMNKG--AREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
||. ..  .   . ||||| ||| |||| .|..|..|. ..|     .|||  . . .|.|| |.| | ||. || .|... .
vnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 954-1219 2.1e-63 209.1 In-house 17-276 (288) alignment 
Range on Protein: 954-1219
Range on HMM: 17-276/288.0
LRNKGRLQREWEALCRYEAEPsAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQG
 ||.  ...|...|   | .  . .|..... |  ||    ||||. || |..| . .| ||.||| | ... .  .|.|.||||..|. .||....|. 
arnrtgfseeynsLaalektk.svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgek.kkkkyiatqgPladtvndfWelvyenk

AVVIVALCRLQENGEVACARYWPEEGA-EVYHIYEVHLVSEHiWCDDYLVRSFYLKnlRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGR
.  || |  | |.|.  | .|||...  . |   .| ||...   .|...|.. |.  .. . ...||...|.|| .|||.... ||...|.|. .    
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk.eledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

rSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVA
 . ||.|| ||| ||||..| || .......    ||.|.|...|| ||| .| | .|.||.  ...
.tgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPRA_pd Subfamily PTPRA 975-1220 7.6e-63 207.4 In-house 48-293 (330) alignment 
Range on Protein: 975-1220
Range on HMM: 48-293/330.0
SAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRaPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARY
.. |.||. .    ||    ||||.|||.|...   |  ||.||| |  .  .   ..|||||.  |.  ||.||||| .  || |  |.|  |  ||.|
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykek.dkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy

WPEEGAEVYHIYEVHlVSEHIWCDDYLVRSFYLK----NLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRScPIVVHGSAGAGRTGV
||.||.  |    |. | ..  . || || | ..    . |  ..| |.|||| |||..|||.... .|.. .||.|  .   . ||||| |||.|||| 
wPdeGlvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGt

YILLDLVLERMnKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
.| || ||||. |  | .|.  ....|| ||. .| | .|.||.  .. |
fivldavlerv.kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 980-1223 8.4e-62 203.6 In-house 4-243 (250) alignment 
Range on Protein: 980-1223
Range on HMM: 4-243/250.0
ASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRaPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVaCARYWPEEG
| .||    ||    ...|.|||||..    .  ||.||| .  .| |  |..|.||||..|. .||.|..|. . .|| |  |.|.... . .||| |.
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

AEVYHIYEVHLVSEHIWCdDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLE
|| |    |.| |....  || .| . | . . .. |.| |.||..||  |||..|.| |....||..| .   . |..|. ||| ||.| .| .| |||
aekyGdvtvsllskeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

RMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
|..|  . .|.   .. || .| ..| ...|. || ... . . 
rlkk.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 940-1221 3.1e-60 199.2 In-house 16-290 (319) alignment 
Range on Protein: 940-1221
Range on HMM: 16-290/319.0
ISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLP
. . .. ||  .|   .. .|. |. ..|.  .. . .. |  .|    || .  |..|...| |..|   |. ||.||| .| .  |   |.||||||.
fpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPld

STLAHFWQMIWEQGAVVIVALCrlqengEVACARYWPEEGAEVYHIYEVHLVSEHiWCDDYLVRSFYLKN-LRTSETRTVTQFHFLSWPHMGVPAQAKAL
 ||| ||.||||. .  || |       .  |..||| .. . .  ..|.. | .  ...| ||.. | .  .  . | .|||||| ||..||| ..  |
ntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsve.etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdl

LDFRRKVNK-SYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
. . .||..   . .   .|||| |||.||||||| || .|.||..  . .|.  ... ||.||  .|    |. |. .|. ||
mrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 949-1224 1.6e-59 196.5 In-house 13-285 (305) alignment 
Range on Protein: 949-1224
Range on HMM: 13-285/305.0
YMEDHLRNKGRLQREWEALCRYeAEPSarEAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQM
 .|..  ..  |. ....|..   |.   .  .. . .  ||  .. ..|..|. |..  . .  ||.||| .  .. |  .|..|||||..|.| ||..
ikearvysdkgleaqykslyee.eesi..dvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgyk.rkkkyivaqgPlkntvadfWrl

IWEQGAVVIVALCRLQENGEVACARYWPEEGAE--VYHIYEVHLVSEHIwCDDYLVRSFYLKN-LRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV
|.|   ..|| |..|.|.|.  | .||||. .|   .  ..|.| ||.    ||. | . . .    .|.|||.|... .||  ||| .| .||.. ..|
iveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksekt.asdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrv

NKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
.|...  .  |..|| ||| |||||.| .|. |||..|   ..|..  | .|| .| ..| | .|. |.  |..|....
qkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkE.evvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
0037934 (Phosphotyrosine protein) phosphatases II 988-1220 2.5e-59 196.1 In-house 13-240 (243) alignment 
Range on Protein: 988-1220
Range on HMM: 13-240/243.0
LNRPGAPLPYDHSRVVLnhlanaEGLDYVNASTITDHdPRapaYVAAQGPLPSTLAH----FWQMIWEQGAVVIVALCRLQENGEVACARYWPeE-GaeV
 ||    ||||||||.|      || ||.||. |.   ||   . | |||||.|...    ||.|.||.|  ||| |..|.|.| . ||.||| .    .
knrysdilpydhsrvkl......egsdyinanliyvt.pr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.gev..t

YHIYEVHLVSEHIwCDDYLVRSFYLKNLR-TSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRG-------RRSCPIVVHGSAGAGRTGVYILL
|. ..|.|.||.  .||| || ..|.||  . .||.|...|.|.||..|||   . |||| ..|.. ..         .. |..|| ||| ||||..|..
ygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaa

DLVLERMnkgarEIDIAATLEHLRDQRAG-VVATRQQFEFVLMAVAE
.|.|...     ..|.  ....||.|| | .| |..|..|. .|..|
ylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPRG_pd Subfamily PTPRG 953-1224 3.6e-59 195.4 In-house 14-289 (563) alignment 
Range on Protein: 953-1224
Range on HMM: 14-289/563.0
HLRNKGRLQREWEALCRYEAEP-SAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEG-LDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIW
|  .. ....|.||| .  ..     |....|.    ||    ..||.||| |. |.. .. |||.||. |  .  .. |..|.||||..|.  ||.|||
hadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiW

EQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDdYLVRSFYLKNLRTSE------TRTVTQFHFLSWPHMGVPAQAKALLDFRRK
|| . .|| .  |.|.|   | .|||....| |   .| |..|.. .  | ||.. .|||.  .       ..|.|.|. .|| .||| ..   | | .|
eqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlal.ytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkk

VNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
 ... . .   ||||| |||.||||.|| || .|.....    ...  .| |.| ||  .|.|. |. |.  |. | . .
ssaank.aeaGPivvHcsaGvgrtGtyivldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_PTPN3_pd Subfamily PTPN3 952-1220 4.6e-59 194.6 In-house 10-273 (280) alignment 
Range on Protein: 952-1220
Range on HMM: 10-273/280.0
DHLrNKGRLQREWEALCRYEAEPsAREAASQPQCAGLNRPGAPLPYDHSRVVLNhlaNAEGlDYVNASTITDHDPR---APAYVAAQGPLPSTLAHFWQM
. | ..|..  ..| | | . .  | .|| .|. .  ||    ||||. || |.   ..|  ||.||...    |       |.|.||||..| ..||||
egl.esGavlaqfeqlyrkkpgl.aisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqm

IWEQGAVVIVALCRLQENGEVACARYWPEEGAEV-YHIYEVHLVSEhIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK
.||| . .|| |  | |.| | | .||||.. |. |  ..|.. .|      |..| ..||. .|.| |...|. .|.||  ||| ... .|.| ..|.|
vweqksslivmlttlverGrvkChqyWPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrk

sYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNkGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
 .|  .. |.||| ||| |||||.|||.. |  ..  |... . . . ..||||| .| | .|..||  |. .
.lrsgkeePvvvhCsaGigrtGvlilletalalie.aaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_PTPN1_pd Subfamily PTPN1 962-1227 5.6e-59 194.2 In-house 6-276 (290) alignment 
Range on Protein: 962-1227
Range on HMM: 6-276/290.0
REWEALC---RYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANaeglDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIV
| .....   | ||.    ..| .|.  .|||     ||||||..|..  |    ||.||| . . .     |. .|||||.| .|||||.||| .  .|
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslv.eleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

ALCRLQENGEVACARYWPEEGA--EVYH---IYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYR-GR
 | .. |.... ||.|||..    |.      ..|.|.||..  . | || . |.||.| |||....||...|| .|||    |.|.|  || .|    .
mlnkvvekeqikcaqywPqgeeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslss

RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAR--EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILK
   | |.| ||| ||.| ..|.| .| ...|      .||  .| .|| .| |.. | .|..|  .|. | .. | .
dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikg
subfamily_PTPRK_pd Subfamily PTPRK 969-1223 1.6e-58 193.0 In-house 27-278 (314) alignment 
Range on Protein: 969-1223
Range on HMM: 27-278/314.0
RYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGE
 ||. .   .|| . .    || |  |.||.|||.|  . .    ||.||. | |   |. |....||||..|.. ||........  || |  |.|.| 
eyeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali.dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgr

VACARYWPEEGAEvYHIYEVHLVSEHIWCdDYLVRSFYLKN--LRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGrRSCPIVVHGSAGAG
| | .||||..   |   .|.||. .. . ...|| | ...     .|.|.| ||.||.||. .|| .|..||.. |.|.||    .  .|||| |||||
vkClkyWPedtev.ygdikvelvetella.elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaG

RTGVYILLDLVLErMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
|||..| .| ||. | .  . .|.  .   ||...  .| | .|. |.  .. | . 
rtGtfiaidivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl
subfamily_PTPN9_pd Subfamily PTPN9 955-1220 5.6e-58 191.3 In-house 11-288 (297) alignment 
Range on Protein: 955-1220
Range on HMM: 11-288/297.0
RNKGR--LQREWEALCRYEAEPSArEAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQ
..||.  |..|.... . ..|  . .|. ..     ||    | ||..||||... . |  ||.||. . |   .  |..|.||||. |   ||.|.|||
kekgkrGlskeyaeirnepveGtf.lasklranleknrytdvlcydetrvvlakvdedeasdyinanfv.dGykqkkafiatqGplkktvsdfWrmvWeq

GAVVIVALCRLQENGEVACARYWP--EEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK---
 ..|||   |. |.| . |..|||  || .. .  ..|. |. .   .|| ||.. .|| .|.|.|.|| | |||||  ||| .|..|||...|| .   
evlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.eedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqa

--------SYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
        . .|. .  ||||| ||| |||| .| ||. |.|... .  .|.  |...|| |||  . | .|.||  .|| |
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg.tvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 963-1221 6.6e-58 191.5 In-house 3-254 (284) alignment 
Range on Protein: 963-1221
Range on HMM: 3-254/284.0
EWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCr
|. ..|.  .. . .. |  .|    || |  |..|...| |..|   |. ||.||| || .  |   |.|.||||. ||| ||.||||. .  || |  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt.

lqengEVACARYWPEEGAEVYHIYEVHLVSEHiWCDDYLVRSFYLKN-LRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKS-YRGRRSCPIVVH
     .  |..||| .. . .. ..|.. | .  ...| ||.. | .  .  . |...||||| ||..||| ..  |. . .||..   . .   .||||
.....kdkcsqywplkivikeerfkvkvdsve.eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

GSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
 |||.||||||| || .|.||..  . .|.  ... ||.||  .|    |. |. .|. ||
csagvgrtgvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Ptp69D_pd Subfamily Ptp69D 947-1221 5.8e-56 184.9 In-house 11-285 (307) alignment 
Range on Protein: 947-1221
Range on HMM: 11-285/307.0
LSYMEDHLRNKGRLQREWEALCRYEAEPSAReAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFW
 ..   .   .  |..|.| | . | . |.. .. .   |  ||  .  ..|. ||.|...   |  ||.||| |  .. .   ..|||.|. .|.  ||
ealksrkrdtdfglakeyekLeareidkstk.vsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekk.kfiaaqdPveatigDfW

QMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIwCDDYLVRSFYLKNLR-----TSETRTVTQFHFLSWPHMGVPAQAKALLDF
.||.||   .|| |  |.|  .  ||.|||.|    |    |.||||.  ..||  |.... .         ..| |.|.|...|. . || .|..||..
RmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkl

RRKVNKSYRGRRScPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
 ..|.. |.  || ||||| |||.||.|... ||..|.....   ..|| .|  .|| ||  .|   .|..|.  |... 
ieqvrelyklnrs.PivvhCsaGvgrsgifvaldsllqqlka.edkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_PTPN23_pd Subfamily PTPN23 950-1226 1.2e-55 183.3 In-house 7-284 (288) alignment 
Range on Protein: 950-1226
Range on HMM: 7-284/288.0
MEDHLRNKGRLQREWEALCRYEAEPSAREA-ASQPQCAGLNRPGAPLPYDHSRVVLNhlanAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQM
 .  | .|. |..... | ..... .   . |     .  ||    |||||.||.|.     .  ||.||| . |  | .| ..|.|.||.|||. ||.|
qrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlm

IWEQGAVVIVALCRLQENGEVACARYWPEEGA--EVYHIYEVHLVSEHiWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVN
..|| . ||| |   .| |.  ..|||||.    ...  ..| | |..   . .  | . |. |.......|.  .. |||..||||  . ||.|  .|.
vyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr.etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

K---SYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAIL
.   . . .   |.||| ||| |||||. |.  ... ..||   .||   ...|| ||  .| ...|..|.. || |... .|
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 989-1223 1.9e-54 179.6 In-house 47-277 (515) alignment 
Range on Protein: 989-1223
Range on HMM: 47-277/515.0
NRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPrAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAE-V-YHIY
|| .  |||| .|| |. . ..   ||.||| |   |    ||.|.|||.....  ||......    |. . .|.|.  . |..|||.  .. | .  .
nryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsi

EVHLVSEHIwCDDYLVRSfyLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVnKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAR
.|.||| .  | . . |   |. |. ...||||||||  ||. ||| ....|| . ..| |. .|. . |...| |||.|||||.| .| |. .... .|
kvelvslea.ctggikrk..ltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikev.kadhgqythpliihcsaGvGrtGvvisidsvvahakt.tr

EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
 .|.  ... .|..|  .| |..|. |.  || |...
mvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPN13_pd Subfamily PTPN13 960-1220 2.2e-54 179.6 In-house 13-267 (273) alignment 
Range on Protein: 960-1220
Range on HMM: 13-267/273.0
LQREWEALCRYEAEPSAREAASQpQCAGLNRPGAPLPYDHSRVVLNHLANaegldYVNASTIT-DHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIV
 . |.. |    .  ..... .. .    ||    ||||..|| |.  ..     |.||| |    .     |.|.||||| | . ||||.||| | ||.
Paeefkelrelkpldtcevgkkk.enkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevia

ALCRLQENGEVACARYWPEEGAEVYHIYE---VHLVSeHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRgrRSC
 .   .|.|.| | |||||.  .   ...   |.|.      |.. ||.. .|.....|.| |....| .||  |||..|. || | ..|..  .   . 
mvtlekekgkvkchrywPesknkklkvsnrlevellk.vqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dag

PIVVHGSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
||||| ||| ||.|..| .| ||. ...   |.|.  ....||.|| ||| |..|. ||  |. |
PivvhcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 975-1224 8.5e-54 177.5 In-house 34-279 (315) alignment 
Range on Protein: 975-1224
Range on HMM: 34-279/315.0
SAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPrAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARY
. . .| ...    || .  ||.|..||.|. . .    ||.||| |   |    ||.|.||||....  ||.|.... .  || .  .||.  . |..|
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdd.dkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

WPEEGAEV--YHIYEVHLVSEHiWCDDYLVRSFYLKNlrTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSyRGRRSCPIVVHGSAGAGRTGVYI
||.. |.   .  ..|.|.| .  . |  .| . ...  . |.||||||.|  ||. ||. |. .|| . ..|  . .|..  ...|| |||.||||| |
wPdrkadsvefGsikvellsle.adtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhcsaGvGrtGvvi

LLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
 .| |...... .| .|.  ... ||..|  .| |.... |.  || |... 
sidevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledllw
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 989-1223 5e-53 174.9 In-house 32-269 (274) alignment 
Range on Protein: 989-1223
Range on HMM: 32-269/274.0
NRPGAPLPYDHSRVVLN-HLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEG-AEV---Y
||  . || ..|||.|. . ...| ..|.||  |   | .  ||||.|||||.|.| ||.||... . ||| | .|.|. |  ||.|.|..  .|.   |
nryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeisery

HIYEVHlVSEHIWCDDYLVRSFYLKNLRTseTRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGR--RSCPIVVHGSAGAGRTGVYILLDLVLERM
   |.. |.. . ..|| ||...||.|    .|.|. . . .|| . .| .|..|||. ..|..| . .  .  |.||| ||| ||||..|  .. . ..
gdveik.vekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrql

NKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
..    .|.  .  .|| .| |.| |..|.|..  |... ..
ree.ivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 951-1224 3.3e-52 172.2 In-house 13-285 (290) alignment 
Range on Protein: 951-1224
Range on HMM: 13-285/290.0
EDHLRNKGRLQREWEALCRYEAEPSAReAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEG--LDYVNASTITDHDPrAPAYVAAQGPLPSTLAHFWQM
..| ... . . ....|   | | ..   .  ..   |||    ..||  |..|..... .    .|.||. | ..   . .|.|.|||...||..||..
nghakgnegfrnqfkmldsgesehtvt.vgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke.kkqyiatqgpvsntlvdFWkl

IWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCdDYLVRSFYLKNLRT-SETRTVTQFHFLSWPHMG-VPAQAKALLDFRRkVN
||..   .|| |.  .|.|.| |  |||..... |  ....|..|..   .|  | . .|| ..  ....|||... .|.. | |....  || ... ..
iwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillviee.my

KSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
|  | |   .|||| |.. ||..|.. ..  ......    ||. . |...| |. | | | ||....   | . .. 
ktqrkrgntsivvHCSdtvgrsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPN14_pd Subfamily PTPN14 951-1218 1.6e-51 170.1 In-house 17-292 (300) alignment 
Range on Protein: 951-1218
Range on HMM: 17-292/300.0
EDHLRnKGRLQREWEALCRYEAePSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAeGLDYVNASTITDH-DPRAPAYVAAQGPLPSTLAHFWQMI
| .|. .|..  |.| . . ..  .  ..|. |. |  ||    |||...|| |.   ..   .|.|||.|      .   |..|||||. |.  ||||.
ekkle.egkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmv

WEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHI-YEVHLVSEHIW--CDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVN
||||  .|| | . .|.|   . .|.|... .  .. .. . |...     | .  ... || | ..| |||  . .  ||  |||   |  |.. ..|.
WeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevq

-------KSYR-GRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAV
       ..     .. |..|| |||.||||| || ||... .... .||||  .|..|| ||  .|.|  |..||  ..
svrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn.eeidikkvlarLreqrmllvqtlaqYkfvYkvl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 989-1218 3.4e-51 168.8 In-house 7-235 (237) alignment 
Range on Protein: 989-1218
Range on HMM: 7-235/237.0
NRPGAPLPYDHSRVVLNHlaNAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEE-GAEVYHIYE
|| |    ||||||||.   .  | ||.||. . . |     |.|||||| |.   ||||.|..   ||| |  | |. |. | .|||.    . | .. 
nrygnivaydhsrvvlkg..agsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvlt

VHLVSEHIWCdDYLVRSFYLK-NLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV-NKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLeRMNKGA
| |  .  .. || |||. |  .|.  | | . |..| |||. ||| |. ||| ||... |.|    .|.| ..| ||| ||||.....| .| |  |  
vslkkkeefs.dytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml.rqakek

REIDIAATLEHLRDQRAGVVATRQQFEFVLMAV
. .||   .  . ..|  .. |..|. |.  ..
kvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 954-1219 5.2e-50 164.9 In-house 6-274 (287) alignment 
Range on Protein: 954-1219
Range on HMM: 6-274/287.0
LRNKGRLQREWEALCRY-EAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANaEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQ
.| |  ...| .||..  |. .    || .   .  || .  ||.|..||.| . ..  | ||.||  .. .  .  |..|||||...|.  ||....|.
rrvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaege.lGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravlet

GAVVIVALCRLQENGEVACARYWPEEGAEV-YHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQA----KALLDFRRKVNK
 . ... . |  |..   | .||||    .    | | |..  |   .| ||.. | .| | |.| | |...||||  ...  |    .  || ..... 
rsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

SYRGRRSCPIVVHGSAGAGRTGVYILlDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVA
.  .    |.||| ..|.||.|...   ||| .. .   ..|.||.. .|| .||..| .  |. ..  |..
ardasevGPlvvhddvGiGrsGilla.tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 963-1224 2.3e-49 162.9 In-house 25-280 (287) alignment 
Range on Protein: 963-1224
Range on HMM: 25-280/287.0
EWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNhlanAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCR
 .  | . . ..     .  .|   .||    |..|  ||.|.     |  ||.||. |  .   . |...|..|. .|.  ||..|...   .|| ||.
qftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcq

LQENGEVACARYWPEEGAEVYHIYEVHLVSEHiWCDDYLVRSFYLKNLR-TSETRTVTQFHFLSWPHMG-VPAQAKALLDFRRKVNKSYRgRRSCPIVVH
..|| | .| .||||| . |.  |...|..|.   ..|..| . .||   ......|.|... .|.  | |. ..  || . ... . .. |   .||||
ekendeevcyqyWpeeksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrk.rgntsivvh

GSAGAGRTGVYILLDLVLERMNKGArEIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
 |.. ||.....  .  ... ..    ||.   |.. | |. | | | .|..|.  .| | ...
CsdtvGrsamfcaaattinkckteG.viDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 989-1224 6.5e-49 161.6 In-house 55-286 (297) alignment 
Range on Protein: 989-1224
Range on HMM: 55-286/297.0
NRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPrapAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvACARYWPEEGAEVYHIYEV
.|    |||| ||| |. . .    |||||| .         ... | | ..|.| ||.|.... . .|| |  ..|. .  |||||...|   .    |
sRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsv

HLVSEHiWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPA--QAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAR
 | | .  .  .. |.. ... ..  .| | |..|..||.  |.   .|..||..   |.|.. .. ..|..|| .|| |||||.. .| |. ....   
vllsvs.ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakr.ek

EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
|.||  ....||..|  .| |..|..||  || | . .
evdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 989-1220 8.7e-49 161.1 In-house 53-277 (315) alignment 
Range on Protein: 989-1220
Range on HMM: 53-277/315.0
NRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEgAEVYHIYEV
||    ..||.||| |  | | .. |||||. |  .. .   |.|||||.....  ||....|.    || |  | |. .  . .|||..   .|  . |
nryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitv

HLVSEHIWcDDYLVRSFylKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKsYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREI
 ..|| .  ..| ||..       .. |.| |.|. ||| ||||. . .|... |.|.. ..    ..|||| ||| |||| .| || ||....   . |
trkseevn.teytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkq.hhtnsvgaivvhcsaGvGrtGtfitldavldqaea.enai

DIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
|.   .. .|..| ..|.. .|..|.  |. |
dvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 989-1220 2e-48 159.6 In-house 12-239 (239) alignment 
Range on Protein: 989-1220
Range on HMM: 12-239/239.0
NRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEvYHIYEV
||    . ||||||||..|.|    ||.||| . |.|    ||.|.|| .  .   ||.|.|..  .||| |  | |  .  | .|||.  .. |    |
nryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.ycnlrv

HLVSEHIWCdDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKS-YRGRRscPIVVHGSAGAGRTGVYILLDLVLeRMNKGARE
 |    ... ||..|.| . ..  .| | | |.||  ||  |||  | |.| .|||. |    | |  | |.| ||| |||| ....| .| |  |  . 
tlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar..pwvihcsagvgrtgaflvidaml.rqakkqkt

IDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
.||   .. .|..|  .| | .|. |. .|| |
vdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 993-1220 2e-48 159.6 In-house 15-238 (239) alignment 
Range on Protein: 993-1220
Range on HMM: 15-238/239.0
APLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEvYHIYEVHLVS
  . ||||||||..|.|    ||.||| . |.|    ||.|.|| .  .   ||.|.|..  .||| |  | |  .  | .|||.  .. |    | |  
nivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk.ycnlrvtlrk

EHIWCdDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKS-YRGRRscPIVVHGSAGAGRTGVYILLDLVLeRMNKGAREIDIA
  ... ||..|.| . ..  .| | | |.||  ||  |||  | |.| .|||. |    | |  | |.| ||| |||| ....| .| |  |  . .|| 
tevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgar..pwvihcsagvgrtgaflvidaml.rqakkqktvdif

ATLEHLRDQRAGVVATRQQFEFVLMAVAE
  .. .|..|  .| | .|. |. .|| |
nyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 986-1224 4.2e-48 158.7 In-house 21-266 (270) alignment 
Range on Protein: 986-1224
Range on HMM: 21-266/270.0
AGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAE--VY
. |||    ||  ..||.|..| . .   |.||  .   | .  .|.||.||||.|| .||.||||. .  || .  |.|.|   |.||||.|  |   .
kklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl

HIYEVHLVSEH-IWCDDYLVRSFYLKnlRTSETRTVTQFHFLSWPHMGVPAQAK------ALLDFRRKVNKSYRGR-RSCPIVVHGSAGAGRTGVYILLD
.  ... ....    . |...   |.  ...|.| .. |.. .||  ||| ..        ||   |.| .| .   .. |..|| ||| ||||. |.||
edgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialD

LVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
 ... ...  ...|..| .|.|| .|  .| . .|.||.  ||.| .. 
iavrlLeet.kkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 972-1223 2.3e-47 156.7 In-house 35-289 (325) alignment 
Range on Protein: 972-1223
Range on HMM: 35-289/325.0
AEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMI--WEqgAVVIVALCRLqENGEV
 .. |...| .|.    ||    ...|.|||||. . ..   ||.||| . |.  .   ..||| ||..|.  .|...  |.  . |.| |  | ..|. 
ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddk.kkdvflaaqaPltatindlWrlvldWr..csvvvvlnel.dlgkd

ACARYWPEE--GAEVYHIYEVHLVSEHIWcDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKS---YRG--RRSCPIVVHGS
 || |||.|   .  .   ||.|..      ||. | . .|. .  |||.| ||.. ||. |||. .  .|. . . |..     .   . | ||.|| |
rcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

AGAGRTGVYILLDLVLERMNKGAReIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH
|| |||||.| |  .|... . .| .||   ...|| .|  .| |  |. ..  |..| . 
aGvGrtGvfislysalakvieesr.vdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 995-1222 9.7e-42 137.9 In-house 58-279 (439) alignment 
Range on Protein: 995-1222
Range on HMM: 58-279/439.0
LPYDHSRVVLNHLANAEGLDYVNASTITD-HDPRapAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvacarYWPEEGAEVYHIYEVhLVSE
 ..||.||.|. .       |.||  |   .|..   |.|.|||   |  .||....|. .| || |. | |        ||| ..  .|    |  |  
gafdhtrvtlqeipgvphshyinanyikGyyddk..lyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiav.rvdr

HIWCDDYLVRSFYLKNLR--TSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIA
 |   .| .| | . | |  |   ||| |||...||.  |||||  .||| | .| .   .   |.||| ||| ||||  | ||. ||...    ..|| 
nielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlkl.enkvdik

ATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
  .. ||.||  .| .  |. |.  || |..
givkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 968-1221 2.5e-41 136.4 In-house 16-265 (283) alignment 
Range on Protein: 968-1221
Range on HMM: 16-265/283.0
CRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANaeglDYVNASTIT--DHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQE
 |    .   . ||  .    ||    .|.|  || |. ...    ||.||. |.  ... .   |..||.||  |   ||.|.... .. || | .|||
krlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

NGEVACARYWPEEGAEVYHIYEVHLVSEhIWCDDYLVRSFYLKNL-RTSETRTVTQFHFLSWPHMGVPAQAKALLDFRrKVNKSYRGRRSCPIVVHGSAG
. ...|..|||..|.| |  . | |  |    . . .. . |..   . .|  .. . .  | ..|  |   .|. |  ||    .  .  ||||| |.|
dlrikCsqyWPkrGsedyGeftvtlrke.ttsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfn.kvislqteskkgPivvhCstg

AGRTGVYILLDLVLERMnKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
 |||.|.| .   .. . .    .|. |... .| || ..| |..|. .|  .| |.
iGrtavfiaasasvkda.ltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_CG7180_pd Subfamily CG7180 986-1221 3.1e-41 136.0 In-house 43-289 (296) alignment 
Range on Protein: 986-1221
Range on HMM: 43-289/296.0
AGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHdPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvACARYWPEEGAEVYHI
 . ||    .|||. ||||..|   |  ||.||. .  .  .  .|.  ..|  .|.  ||........  .| |..  .  .  .  |||... | |  
reknrdvkvvPyDynRvvLekldGeeksdYinavyvdsf.lkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqyge

YEVHLVSEHIWCDdYLVRSFYLKNL----------RTSETRTVTQFHFLSWPH-MGVPAQAKALLDFRRKVNkSYRGRR-----SCPIVVHGSAGAGRTG
 .|..|.|. . .    | | |.             . |||.|..|..  |.    ||  ..||...||.|. ..|..        |.||. | ||.|.|
ifveiveekqyan.lkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvr.lwrekvdedpeegPvvvvssdGasRsG

VYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
||. .|  || ..|   |.|.   .  || .| ..| . ... ..   . | 
vylaidanlelvek.eeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 978-1222 2.6e-39 129.7 In-house 38-236 (392) alignment 
Range on Protein: 978-1222
Range on HMM: 38-236/392.0
EAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRaPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGevacarywpe
 .| ..     || .  |||| .||.|. . .    ||.||| |   |    ||.|.||| ...|  ||.|.... .  |. . .|.|            
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

egaevyhiyevhlvsehiwcddylvrsfylknlRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYrGRRSCPIVVHGSAGAGRTGVYILLDLV
                                 .  ..|||.||||  ||  .|| .. .|| | ..|.  . |. . |...| ||| ||||| | .| |
.................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadf.Gqythpliihcsagvgrtgvvisidsv

LERmNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
. .  | .| .|.   .  .| .|  .| |..|. |.  || |..
vah.akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
0041856 (Phosphotyrosine protein) phosphatases II 988-1222 6.6e-38 125.5 In-house 4-171 (182) alignment 
Range on Protein: 988-1222
Range on HMM: 4-171/182.0
LNRPGAPLPYDHSRvvlnhlanaeGLDYVNASTITDHDPRAPaYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCrlqengevaCARYWPeegaevyhiye
.||    |||||||          .|||.||. .    |    ..|.||||.||.|.|..|..|.|  .|| |.         . .|||           
knrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp...........

vhlvsehiwcddylvrsfylknlrTSETRTVTQFHFLSWPHMGVPAqAKALLDFRRKVNKsyrgrRSCPIVVHGSAGAGRTGVYILLDLVLERmnkgarE
                        . ..|...|...|.|| .|||     |||| ..|..     ...|..|| ||| ||||......|....      .
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl......g

IDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
...  .....| .| |.| | .|. |. .|. |..
vsleeavklvrsrRpgmvitpnqyfflqlallell
0051429 (Phosphotyrosine protein) phosphatases II 1014-1224 1.1e-37 125.6 In-house 5-227 (272) alignment 
Range on Protein: 1014-1224
Range on HMM: 5-227/272.0
DYVNASTITDHdPR---APAYVAAQGPLPSTLAHFWQMiWEQGAVVIVALCRLQENGEVACARYWP------------EEGAEVYHIYEVHLVSEHiWCD
.|.||. .     |     .. ...|||| | |.||.. .|.|  .|| |... | | . | ||||            ..    |. . | |.||. ...
gyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee.lll

DYLVRSFYLKNL-RTSETRTVTQFHFLSWPHMGVPAQAkaLLDFRRKVNKsyrgrrSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREID-------I
||..| ..|..|  ..|.|.|...|...|| .||| .|  ||.. . ...      . |..|| ||| .|||....|.|.|..... .   |       .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

AATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
....|.||.||.|.| | .|..|...|..| . .
eeaveelraqrpgavqteeqylflyeallellrs
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 971-1222 9.7e-37 121.4 In-house 19-295 (297) alignment 
Range on Protein: 971-1222
Range on HMM: 19-295/297.0
EAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHlaNAEGLDYVNASTITDHDPRAP-AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEV
||.. .  .| .. .   ||    | .| .|| |       . ||.||  ..  |  |.  |. ||||| .|.  ||....||.  ||| ...|||.|  
eargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrd

ACARYWPEEGAEVYHIYEVhlVSEHI--WCDDYL-VRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRR--------------KVN------
 || |||.   |  .  .|  | |..    |..  |    |. .  ||.| |.   |||||  |||.. . |  |.                |.      
kcapywpsvvqerlkagdv..vveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamv

----KSYRG--RRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
    .|.|    |. ...|| ||| ||.|| .| | .|... |. |  |.|| |..||.||| .| | .|||..  || . .
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 982-1219 4.1e-33 109.4 In-house 37-290 (301) alignment 
Range on Protein: 982-1219
Range on HMM: 37-290/301.0
QPQCAGLNRPGAPLPYDHSRVVLNHLAN--AEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEG
. . . |||     .||. |..|..  |      .|.||| | .   .. ...|||||. .||. ||..||..  | || .. |.|. .  | .|||.  
seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnse

AEVYHIYEVH-LVSEHIWCDDYLVRSFYLKNL---------------RTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSA
|| .. .... .....    |...|.. .|                 .. ....|.|..  .||. ||  . .  |    .| .  .     |.||| |.
aeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSd

GAGRTGVYILLDLVLERMnKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVA
. .|.|||. ... ||   |    .|.    . .| .. |.| | .|. ..  .. 
tVsrsGvYcsvsiglEQc.kaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
0043147 (Phosphotyrosine protein) phosphatases II 1011-1215 8.3e-33 108.9 In-house 3-154 (172) alignment 
Range on Protein: 1011-1215
Range on HMM: 3-154/172.0
EGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLqengevacarywpeegaevyhiyevhlvsehiwcddylvrsfylKNL
|| ||.||| . |     . ..| ||||..|||.||.|..|.|  .|| |..|                                             ..
egsdyinasyl.dlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lyd

RTSETRTVTQFHFLSWPHMGVPaQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLermnkgaREIDIAATLEHLRDQRAGVVATRQQ
.. ..|.. |...|.|| .|||  .. ||.| . ... .  ....|..|| ||| ||||. ....|.|       . ...  .....|..| |.| . .|
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsq

FEFVL
  |..
yrfly
0036282 (Phosphotyrosine protein) phosphatases II 1014-1215 1e-32 108.6 In-house 3-163 (174) alignment 
Range on Protein: 1014-1215
Range on HMM: 3-163/174.0
DYVNASTItDHDPRAPAYVAAQGPLPstlahFWQMIWEQGAVVIVALCRLQENGEVACARYWPEegaevyhiyevhlvsehiwcddylvrsfylknLRTS
|| ||| . |   . | ..| ||||.     ||.|..|.|  ..| |....|.| . | .||||                                ||..
dyinaspl.dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lred

ETRTVTQFHFLSWPHMGVPAQAKaLLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNkgAREIDIAATLEHLRDQRAGVVATRQQFEF
..|.. |...| || .|||  .. ||.| . |.. .   ...|..|| ||| ||||. ....|.| ..    . .|. ...  || || |.| | .|..|
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyrf

VL
. 
ly
subfamily_ptpA1_pd Subfamily ptpA1 971-1204 1.9e-32 107.5 In-house 33-278 (418) alignment 
Range on Protein: 971-1204
Range on HMM: 33-278/418.0
EAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRapAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVA
   ||      . . .  ||    || .|.|| |... . || ||.||  |    |.   ....||||| |.| ||.|.||. . .|| | |  ||  . 
svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk..qfictqgplpntiadfwrmvwenrcriivmlsresencrik

CARYWPEE-----------GAEVYHIYEVHLVsEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV----NK-SYRGRRS
| |||||.           | ||.  | | || | |   .  . .  ..     ||| .||...  ||   .| ... . .. . .    |.      | 
cdrywpeqiggeqfsiygngnevfgtysvelv.eviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrn

CPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDiAATLEHLRDQRAGV
 ||.|| ||| |||| .    ........  ...| |. .... |  . .
vpiivhcsagvgrtgtfctavimmkkldhyfkqld.atpidqvvdpfthl
0046846 (Phosphotyrosine protein) phosphatases II 1013-1218 2.3e-32 107.5 In-house 12-169 (176) alignment 
Range on Protein: 1013-1218
Range on HMM: 12-169/176.0
LDYVNASTITDHdprapAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYhiyevhlvsehiwcddylvrsfylknlrt
|||.||. |  .     ...| |||||.|||.|..|..|.|  ..| |. ..| | . |..||||. .. .                             
ldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

setrtvtQFHFLSWPHMGVPAQaKALLDFRRKVNKSYRGRrsCPIVVHGSAGAGRTGVYILLDLVLERmnkgaREIDIAATLEHLRDQRA-GVVATRQQF
       |...| || .|||   ..||.. . ... ..     |..|| ||| ||||......|.  .     . ...  .|...|.||  |.| |..| 
.......qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpeQy

EFVLMAV
.|. ...
rflyefe
0049260 (Phosphotyrosine protein) phosphatases II 1030-1215 5.7e-32 105.9 In-house 10-143 (152) alignment 
Range on Protein: 1030-1215
Range on HMM: 10-143/152.0
AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWpeegaevyhiyevhlvsehiwcddylvrsfylknlrtsetrtvtQFHFLSWPHM
...|.|||.| |||.||.|..|.|. .|| |..|.|.|.. |..|.                                            |...| || .
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwpDh

GVPAQAKALLDFRRKVNKSyRGRRSCPIVVHGSAGAGRTGVYILLDLVLermnkgaREIDIAATLEHLRDQRAGVVATRQQFEFVL
|||  .  ||.. . ..|  . ....|..|| ||| ||||......|.|       . ...  .....| .| |.| . .| .|..
gvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
0049772 (Phosphotyrosine protein) phosphatases II 981-1222 3.5e-29 97.9 In-house 42-280 (314) alignment 
Range on Protein: 981-1222
Range on HMM: 42-280/314.0
SQPQCAGLNRPGAPLPYDhSRVVLnHLANAEGLDYVNASTITDHdpraPAYVAAQGPLPSTLAHF----------WQMI--WEQGAVVIVA---------
...     ||    ||.| .||.| .  . .| || ||| .  .     ...|.||||. |.  |          |.|.  ...   .||          
dlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LCRLQENGevacaRYWPEEGAEVYHiyevhlvsehiwC-----DDYlvrsfylknlrtseTRTVTQFHFLSWPHMGVPaQAKALLDFR
            |..| .||      .....  | ..                  ...              .|.. ... . .|  ..|   . ...| 
lsrLdaAlgKtpllildgng.....neptaadlellk............eelydpelf..............erlgikylripvpDgsap.lledfdefl

RKVNKSyrgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNkgareIDIAATLEHLRDQRA-----GVVATRQQFEFVLMAVAEEV
. ...    ..  |..|| .|| ||||......... ...     .... .||..| .|      | . . .|.||.|.|. | .
efieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg.....vsleealedvrlkRpinpnpgfieqleqyefilealleyl
0051082 (Phosphotyrosine protein) phosphatases II 1014-1218 5.2e-28 92.9 In-house 4-149 (151) alignment 
Range on Protein: 1014-1218
Range on HMM: 4-149/151.0
DYVNASTITDHdprapaYVAAQGPLPstlaHFWQMIWEQGAVVIVALCRLQENGevACARYWPEEGaevyhiyevhlvsehiwcddylvrsfylknlrts
|| |.| .|..      . . .|||.    .|.....|.|  .|| |. ..|.|   |..|.||.|                                  
dyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

etRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKsyrgRRSCPIVVHGSAGAGRTGVYILLDLVLERmnkgareIDIAATLEHLRDQRAGVVATRQQFEF
  ..|.....|.||  |.|   .|.|.| .....     .. |..|| ||| ||||. ..|.|.|..       ......||..| .| ||| . ||| |
..ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflf

VLMAV
.|.|.
qlfal
0044763 (Phosphotyrosine protein) phosphatases II 996-1216 9.1e-28 92.5 In-house 1-165 (178) alignment 
Range on Protein: 996-1216
Range on HMM: 1-165/178.0
PYDHSRVVLNHLANAEGLDYVNASTITDHdprapAYVAAQGPlpstlAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAevyhiyevhlvsehi
|.|..||.|..| . |. || ||| |...      |.....|     |.......|.|  .|| |.  .|.| . | .|||||                 
pldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

wcddylvrsfylknlrtsetrtvTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERmnkgarEIDIAATLE
                        |.... .| .|||   . .|.| . ... .  .. .|..|| ||| ||.|. ....|....       ... . .|
.......................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaie

HLRDQRAgVVATRQQFEFVLM
..| .|  .| .. | .....
lvrerRp.ivpnpgqlrqLye
PTPc_DSPc_SM00012 1117-1220 9.6e-28 91.8 In-house 1-105 (105) alignment 
Range on Protein: 1117-1220
Range on HMM: 1-105/105.0
TVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRR-SCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVL
||...|...||..||| .....|.. |.|.|... .  | |.||| |||.||||....||..|....|. .|.||  ....||.||.|.| | .|. |..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

MAVAE
.|..|
ralle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 998-1214 1.9e-27 90.7 In-house 69-275 (290) alignment 
Range on Protein: 998-1214
Range on HMM: 69-275/290.0
DHSRVVLNHlanAEGLDYVNASTITDHDpraPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLV-SEHIW
| .||.|.        ||| |  .   .   . .. .||.| .|   .|.|. .... .|| || | |.|   |..|.||.  ||  . |. .. ||.  
dktrvilkd...GydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseedd

CDD-YLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSyrgrrSCPIVVHGSAGAGRTGVYILLDLVLERMNKGaREIDIAATLE
 |.    . . ...  .     .  ..  |||   |.  . |||   | . |      | |.||| ||| |||| .. ..  |. . .| .|.|.. .  
kdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.....sGpvvvhcsaGiGrtGtfvaievglqilldG.keldlldlvr

HLRDQRAGVVATRQQFEFV
 ||. |.. |    |.  .
alrnsrlnsvqvdiqylal
subfamily_CG42327_pd Subfamily CG42327 983-1148 3.5e-27 89.9 In-house 26-193 (319) alignment 
Range on Protein: 983-1148
Range on HMM: 26-193/319.0
PQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEE----
. .   .|    .|  ..||||.. .. .   |..|| .  .|     |.||| .| .. . ||...||| . ||| |. |.|.|   ||.|.| .    
vtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

GAEVYHIYEVHLVSEHiWCDDYLVRSFYLKNLRTSETRTVTQFHFlSWPHMGVPAQAKALLDFRRKVNKS
. ..|  . | |       | |.. .. ||..  .|.| .| . .  |.. .|||. .||.    .|..|
ntslyGdilvtlkgre.vkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 997-1215 4.3e-27 89.5 In-house 49-262 (281) alignment 
Range on Protein: 997-1215
Range on HMM: 49-262/281.0
YDHSRVVLNH-LANAEGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHI
 | ||| |.  . | .  ||. |  |         |. .|||   | | ||.|||.. .  || ||.. |     || |.| .   . .. .. .  |  
ldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyeds

WCDDYLVRSfYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKsyrgrRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLE
  .  || .  |.     ||| .|.. .  ||   ||  .. .|   ||.       || | |.| ||| ||.|  . ... |. .       ||   . 
tvnkslvtt.rlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira.....rstppvihcsagvgrsgtlmaveialqsihshftlpdikqivs

HLRD-QRAGVVATRQQFEFVL
|||   ||  | | ||. .. 
hlrvtgraasvqtlqqymliw
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 997-1214 7.7e-26 85.8 In-house 53-269 (307) alignment 
Range on Protein: 997-1214
Range on HMM: 53-269/307.0
YDHSRVVLNHLANAegLDYVNASTITD-HDPRapAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEE-GAEVYHIY------EV
 |..|.|..    |   ||. |  .    .|.   ...||||| .|  .|| |. ..    .. ||.. | ... | .||| | | .  .          
qdkgrivvkfdgla..sdyihanylgiaikpk..kficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisva

HLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSyrgrrSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREI
 | ....  |. |.    ||   ....||.... .  ||  |||    . ...   |.         |.||| ||| ||.|  . . || ..| .|    
nlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd.....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinck

DIAATLEHLRDQRAGVVATRQQFEFV
|.   .| ||.||   . |  |. ..
dmkklveelrsqrhyaiqteaqylyl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 959-1227 2.3e-25 84.1 In-house 7-264 (267) alignment 
Range on Protein: 959-1227
Range on HMM: 7-264/267.0
RLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAegldYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIV
 ...|.| . .   . |        . .  ||    ||||..||.|    .     |.||| .  .  .  |... |.||  | ..|...| .|.  |||
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpviv

ALCRLQEnGEVacARYWPEE--GAEVYHIYEVHLVSEHiWCDDYLVRSFYLKnLRTSETRTVTQFHFLSWPHMGV-PAQAKALLDFrrkVNKSYRGRRSC
 | .  . ...   ..|| .   |. |.   |    |.   .|| . .. || ..   .. || ...  |          | |.     . |      . 
lltkvft.dni..rlfwPPkmgqakkyqdltvehslek.eendyqiitlelk.fknesahnvtlyyykkwnintnnkpylkplfgi...laknqlengnr

PIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILK
|.||. |.| ||.| .. .|  |||. .     ||   | ..|.|| |.| |.... ..   .||  .  ||
PlvvacsdGvGrsGtflvidsqlerakt.egvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1007-1214 2.7e-24 80.3 In-house 74-281 (305) alignment 
Range on Protein: 1007-1214
Range on HMM: 74-281/305.0
LANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEvHLVSEHIWCDDYLVRSF-
|..    ||. |  .         ...|||||  |. .|| |. ..    || ||.  | | . ||.|||    |  ..    .| | .     . |   
ldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks.givvenvsgskpmerdae

---YLKNLRT--SETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVnksyRGRRsCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQ
    | ||    ... .| ....  ||  |||    . |..   .    || .  ||||| ||| ||||  . .. .||.. .  .   .   .  ||||
iqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai....rgsk.vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdq

RAGVVATRQQFEFV
||  . .  |. |.
rafsiqndvqylfi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1030-1214 2.9e-24 80.4 In-house 6-196 (199) alignment 
Range on Protein: 1030-1214
Range on HMM: 6-196/199.0
AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIW-CDDYLVRSFYLKNLRTS--ETRTVTQFHFLSW
 |.|.| ||  |.| ||||.|| |.  || .   | | |.  . |||   . . .   . .... |    || . .. | |  |.   || .... | ||
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PHMGVPAQAK--ALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNK-GAREIDIAATLEHLRDQRAGVVATRQQFEFV
     |  |    ..   |.| | |   . .|..|| | | | |||.. ||. .   ..  .  .|.      ||. | |.... |...|.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1030-1214 3e-24 80.3 In-house 5-195 (198) alignment 
Range on Protein: 1030-1214
Range on HMM: 5-195/198.0
AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIW-CDDYLVRSFYLKNLRTS--ETRTVTQFHFLSW
 |.|.| ||  ||| ||||.|| |.  || .   | | |.  . |||   . . .   . .... |    || . .. | |  |.   || .... | ||
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PHMGVPAQAK--ALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNK-GAREIDIAATLEHLRDQRAGVVATRQQFEFV
     |  |    ..   |.| | |   . .|..|| | | | |||.. ||. .   ..  .  .|.      ||. | |.... |...|.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 961-1215 5.1e-24 79.5 In-house 25-280 (305) alignment 
Range on Protein: 961-1215
Range on HMM: 25-280/305.0
QREWEALCRYEAEpSAREAASQPQCAGLNRPGAPLPYDHSRVVLnhlANAEGLDYVNASTITDhDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVAL
. |. |. |..      .|  . | || ||       |. || |    ..   .|. |  ..     .  .. .| ||  | | || | ...    |  |
raefvamkrfndf.ekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifml

CRLQENGEVACARYWPEEGAEVYHIYEVH-LV-----SE-HI----WCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSy
| |.| |   |. |.. .  .| .. |    .     |   .     ..  . ..  . .   ...| ||..|.  ||  ||||   |.|..  |   | 
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps.

RGrrscPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVL
.|    ||||| ||| ||||  ..|. .|...  |    |    | ..|.||   . | .|. || 
kg....pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1030-1214 8.4e-24 78.8 In-house 91-273 (301) alignment 
Range on Protein: 1030-1214
Range on HMM: 91-273/301.0
AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHI--YEVHLVS-EHIWCDDYLVRSFYLKNL-RTSETRTVTQFHFLS
 ..|.||||..|   || |.       || |..  |. |  |. | | . .|  .|  ....... |.|  ..   |.. ...  .  .||||| . . .
rfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqyse

WPHMGVPAQAKALLDFRRKVNKSYRgrrscPIVVHGSAGAGRTGVYILLDLvLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFV
|.. |||     | |.   | || .     ||||| ||| ||.  .|  .  | |  .  ..|... .|.|||..|   | |..|. ..
wtdrgvPkshaelfdlmelvkksek.....PivvhcsaGiGrsvafigtey.lareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 998-1222 1.8e-23 78.0 In-house 56-271 (288) alignment 
Range on Protein: 998-1222
Range on HMM: 56-271/288.0
DHSRVVLNhlanaEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWC
| .|| |.     .  |.  |. .    .     . || || .|.  .|.|. |..   || ||.| | |  . | |.| .  |  .|  .  |  .   
ditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkra

-DDYLVRSFYLKNLRTSETRT-VTQFHFLSWPHMGVPAQAKALLDFRRKVnKSYrgrrSCPIVVHGSAGAGRTGVYILLdLVLERMNKGAREIDIAATLE
  | ||.   |.. .. |..  | . |.| |.. ||| . .. | .   . ||.      ||||| |||.||||  ||  |.  .. .    . |   |.
didklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.ksl....qkPivvhssaGvGrtgtlili.lialeslrlddflgirslla

HLRDQRAGVVATRQQFEFVLMAVAEEV
.||..|   . | .|. .|   | ||.
klreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 998-1220 2.6e-23 77.4 In-house 48-268 (285) alignment 
Range on Protein: 998-1220
Range on HMM: 48-268/285.0
DHSRVVLNhlaNaEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYH--IYEVHLVSE-H
. .||||.   |    ||. || .        .|...||||| ||. ||.||...    .. || | | |   || |.||.  || .   ||. |     
eetrvvlk...n.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitltecke

IWCDDYLVRSFYLKNL--RTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYrgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAA
      .. .. . |    .||   . . .   ||    | .|. .... . |.|     .  ||.|| ||| |||  .. .|    |. .   .|..  
eaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvn..pkekpicvhcsagvgrtatfvgidyatirime.npniemld

TLEHLRDQRAGVVATRQQFEFVLMAVAE
 .  .|  |   | .. || |. . . |
ivremramrfqavqshmqflflyvvlme
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1041-1222 5.7e-21 69.7 In-house 40-221 (255) alignment 
Range on Protein: 1041-1222
Range on HMM: 40-221/255.0
TLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHiWCDDYLVRSFYL-KNLR-TSETRTVTQFHFLSWPHMGVPAQAKAL
|...|.|.|  ... |.| || ..|.| . | .|.| |  |   . .| ... .    | ..|   .  .|    .|.||. ...  |.    | .|. .
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LDFRRKVNKSyRgrrscPIVVHGSAGAGRTGVYILLDLVLERMNK-----GAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
|   . | .| .     ..||| |.| ||.  ..| .||  .| .      . |.|    ||.|| .|.. . |  |. | .. | . |
lnilkvvrds.k.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1099-1222 1.9e-19 64.3 In-house 76-194 (440) alignment 
Range on Protein: 1099-1222
Range on HMM: 76-194/440.0
DYLVRSFylknLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLeRMNKGAREIDIAATLEHLR
||.  |.    .   |.||. |.|. .||  |||  |  .| . . ||.|     . |..|| ||||||||| | .| .| |  | . .||| . .. .|
dyinasy....ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsil.reakrsdqidifsfinsmr

DQRAGVVATRQQFEFVLMAVAEEV
..|  .| | .|. ||  || | .
nnrpqmvqtpeqyafvheavlegl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 997-1214 2.4e-19 64.1 In-house 64-282 (310) alignment 
Range on Protein: 997-1214
Range on HMM: 64-282/310.0
YDHSRVVLNhLANAEGLDYVNASTITDHDPRApAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEG-AEVYHIYEVHLVSEHI
 | ||| |. . ..   ||. |  .     |. ... .||||  |.  ||.||... |  |. ||.  |.|   |  |||  | .| |    |  .||  
ldtsrvklk.idksryedyihanyvktnylrs.tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsess

--WCDDYLVRSFYLKNLRTSETR------TVTQFHFLSWPHMGVPAQAKALLDfRRKVNKSyrgrRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGArE
  .    |  .|   |.   |         |.  ..  || .||| .    .  .| . .     |  | ||| ||| .|..| . |.| ......|  .
eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp.qrllaqv....rhgpcvvhcsagkdrlyvvvalklkidkldrgl.k

IDIAATLEHLRDQRAGVVATRQQFEFV
.|.     .|. .|| .. |  |. ..
vdaeevktellksraiciqtelqylii
subfamily_hpo-7_pd Subfamily hpo-7 1039-1220 5.1e-19 63.2 In-house 44-225 (263) alignment 
Range on Protein: 1039-1220
Range on HMM: 44-225/263.0
PSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCdDYLVRSFYLKN-LR-TSETRTVTQFHFLSWPHMGVPAQAK
  |.. |.|.|  ... |.| ||  .|.| . | .|.| |  |   . .| ... ..   | |...  | . |    .|.||... .  |..   | .|.
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpelar

ALLDFRRKVNKSyRgrrscPIVVHGSAGAGRTGVYILLDLVLERMNK-----GAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE
  |   . . .| .     ..||| |.| ||.  . . .||  .| .      . |.|    ||.|| .|.. . |  |. | .. | .
eilnilkvarns.k.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
0048076 (Phosphotyrosine protein) phosphatases II 1105-1218 6.5e-19 63.5 In-house 34-139 (145) alignment 
Range on Protein: 1105-1218
Range on HMM: 34-139/145.0
FYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRrsCPIVVHGSAGAGRTGVYILLDLVLErmnkgaREIDIAATLEHLRDQRAGV
. | . .. ..|...|...|.|| .|||  .. ||.| . ... ..    .|..|| ||| ||||......|.|.      . ...  .||..| || |.
lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpga

VATRQQFEFVLMAV
| . .|..|.....
vpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 1100-1216 5.9e-18 60.4 In-house 31-139 (144) alignment 
Range on Protein: 1100-1216
Range on HMM: 31-139/144.0
YLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRgrRSCPIVVHGSAGAGRTGVYILLDLVLermnkgAREIDIAATLEHLRD
..| ..  .   ....|...|...|.|| .|||  .. ||.| . ... ..  ...|..|| ||| ||||......|..       . ...  .|...| 
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrs

QRAGVVATRQQFEFVLM
.| |.| ...|..|.|.
rrpgavpnpgqlrfLle
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1037-1222 8.7e-17 55.5 In-house 99-288 (302) alignment 
Range on Protein: 1037-1222
Range on HMM: 99-288/302.0
PLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEV--YHIYEVHLVSEHIWCDDY------LVRSFYLKNLRTS--ETRTVTQFHFLSW
|  |||  .| .| .    ..| || . |..|  || |. ..  ..  .  | |. || .   ...       . .  .|| ..     .||  ..| .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PHMGVPAQAKALLDFRrKVNKSYRGRrscpIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV
|. | |..|.. ||   |  .||.      ..|| ||| ||||  . .   ..   |  .  |..  .  .|. | | | . ||  ..|. |.  .
pdhGapkeaytaldil.kfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcsk.kkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 988-1085 2.2e-16 54.5 In-house 50-160 (350) alignment 
Range on Protein: 988-1085
Range on HMM: 50-160/350.0
LNRPGAPLPYDHSRVVLNHLA--------NAEGLDYVNASTITDH---DPRAPA--YVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARY
 ||    |||.|||| |..            .. ||.||. .          |   |.|.|.|||||.  |...| . .  ||..|  ..|..   | ||
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY

WPEEGAEVYHI
|.| . . ...
Wqegsydditv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1029-1222 5.9e-16 53.1 In-house 82-276 (312) alignment 
Range on Protein: 1029-1222
Range on HMM: 82-276/312.0
PAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPE-------EGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQF
  .|..|||| .| .||||.    |.. |. || . |.|   ||.|  .       |   ||  |   .       |    | . .    | .   . ..
erfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhy

HFLSWPHMGVPAQAKALLDFRRKVNKSYRgrrscPIVVHGSAGAGRTGVYILLDLVLERMNKgAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEE
 . |||  |.|    . | .   |.|  .     |.. | ||| ||||  .|.. ..  . .  |  ..  ..  || .||  | .  |. ..| .| | 
qwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalrh.prkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

V
.
l
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 999-1219 7.8e-16 53.0 In-house 32-256 (290) alignment 
Range on Protein: 999-1219
Range on HMM: 32-256/290.0
HSRVVLNHLANAEGLDYVNASTITDhdPRAPAYVAAQGPL-------PSTLAHFWQMIWEQGAVVIVALCRLQENGEV----ACARYWPEEGAEVYHIYE
..||||.   .    ||. |. .|   |   . .. | |.        ||. .|| |. .  .  .| ||  .|. .     |||.| ||.  |   .  
atrvvLkgygkrfnddyiHAnrvtc..pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

VHLV-SEHIWCDDYLVRSFYLKnLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSyrgrrSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAR
. .   . .  ||  .|   .|     |  |||   . .| .. |. . | ||.  .||..|       |..||   |  |  .   ..|    . .   
ltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvkas.....ktpvivHcvdGiSrsAalaaiilgyQkiaetsg

EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVA
.. ... |. || ||| .. . ... ||. .. 
svkledvlkalrkqralaitsalelafvdagiv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 998-1219 2.3e-13 44.2 In-house 64-282 (302) alignment 
Range on Protein: 998-1219
Range on HMM: 64-282/302.0
DHSRVVLNHLANaeglDYVNASTITDHDPRAPAYVaAQGPLPSTL---AHFWQMIWEQGAVVIVALCRLQENGEvACARYWPEEgAEVYHIYEVHLVSE-
|. .| |.. ..    .|||||...  . . . .. || |  ..    ..||.|....  | .| | . .|  . .   ..|.. .. |. |.   |   
dsnlvkleaepd....syvnaskvevPeltrsiil.aQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkk.sgdykeygkmfvNnr

HIWCDDYLVRSFYLKNLR--TSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV-NKSYRGRRSCpiVVHGSAGAGRTGVYILLDLVLERMNKGaREIDI
 .   .  .  ...  |    |..  ..  ..  |..  || .  .|     || .|.  .  ..  |.    |||| |. . | ...|...||  |  |
kVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadent..vivSknGaGRagafltlavaveklqkg.kepni

AATLEHLRDQRAGVVATRQQFEFVLMAVA
. ... .| ||. .| . .|. .. .|..
keivksiRsqRpravdslkQyvslyiall
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 997-1224 9.4e-13 42.4 In-house 59-281 (303) alignment 
Range on Protein: 997-1224
Range on HMM: 59-281/303.0
YDHSRVVLNHlanAeglDYVNASTItDHDPRAPAyVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAevYHIYEVHLVSEHIW
 |||.| |     .    |. || . . | .  | . .| ||. | | ||||| ||   ... |    |  ..     .|..    .  .|   .    .
ldhskvklsd...s...syihasyl.eldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd..flkfeersirvgef

CDDYLVRSFYLKNLRTSETRTV---TQFHFLSWPHMGVPAQ-AKALLDFRRKVNKSYRG-RRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIA
    |.  . || |  |.          |. .|||  .|.. .  ..    ...   |    | | |    .| ||.| . |..     . .    .|. 
krvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlv

ATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA
  || .|. |   |    || .|   .|| |  
kclenvrngrlhavqnlsqfsvvytllaehvld
subfamily_CG42327_pd Subfamily CG42327 1152-1218 2.7e-12 41.0 In-house 245-311 (319) alignment 
Range on Protein: 1152-1218
Range on HMM: 245-311/319.0
RRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAV
 .  |.||| | |.||||. |  |. ......  | .||  .. ..| .||  | |..|.||.   .
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 972-1078 1.3e-11 38.6 In-house 83-181 (244) alignment 
Range on Protein: 972-1078
Range on HMM: 83-181/244.0
AEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHlaNAEGLDYVNASTITDHdPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvac
 .||  . | .|. .  || || ||.| .|| |..   . |  |.||| .     |.  |. .| ||  |   ||.|. |.   |.| |  ..|. |   
pdpsvmkdafnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgcl.grtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede...

arYWPEE
  |||. 
..ywpds
subfamily_egg_pd Subfamily egg 998-1219 4.7e-10 33.6 In-house 53-267 (307) alignment 
Range on Protein: 998-1219
Range on HMM: 53-267/307.0
DHSRVVLNHLANAEGLDYVNASTITDhDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENgeVACARYWPEEGAEVYHIYEVHLVSEHIWC
| ||| |.        |.. |  .   .|    .. || ||  |   ||.|....    || |   .|.    |  |||   ..   .    |  | .  
dssrvklelrrGqylddfihanrvkG.kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkv

DDYLVRSFYLKNLRTSETRtVTQFHFLSWpHMGVpaQAKALLDFRRKVNKSYRgRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGA-REIDIAATLEH
|.     | . .|.   .    . .   |    |  .  . . .  .| .  | . | |.||.   |  .... . ... |  . .|      .  .   
dskadplfrvtklklvGgd.deerflehw.qgdv..nnssdvysplrvlrklr.nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvf

LRDQRAGVVATRQQFEFVLMAVA
|| .|   | .  .. ||   |.
lrlrrrlsvesvllylfvyrlvl
subfamily_eak_pd Subfamily eak 995-1142 9.6e-10 32.4 In-house 61-204 (332) alignment 
Range on Protein: 995-1142
Range on HMM: 61-204/332.0
LPYDHSRVVLNHlANAEGLDYVNASTItDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEV--YHIYEVHLvS
.|||.  | |   .  . | |.||| . .       |. .  .  . .  ||||. || .  || |    |..     .|.|... |.  . |..|.   
vpydrylvrlts.sqlnrlGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildver.k

EHIWCDDYLVRSFYLKnlRTSETRTVTQFHFLSWPHMGVPAQaKALLDFR
|..  . . .| . |.  .  ||  |  ...  |  . .|   . .| .|
efvkrniletrllels..kGnethrvlhykvfGwtettlpky.edflalr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1143-1217 4.7e-09 30.4 In-house 251-339 (350) alignment 
Range on Protein: 1143-1217
Range on HMM: 251-339/350.0
RKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLE------RMNKGAREIDIA--------ATLEHLRDQRAGVVATRQQFEFVLMA
   .. .   || ||.|| ||| ||||... || .|.       ..|  |..| |         .. .|| ||  .| . .|| |.  |
lfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYea
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 992-1084 6.9e-09 29.5 In-house 55-162 (349) alignment 
Range on Protein: 992-1084
Range on HMM: 55-162/349.0
GAPLPYDHSRVVLNHLANA--------------EGLDYVNASTI--TDHDPRApAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYW
   |||.||||.|..  ..                 ||.||  .  |  ..    |.| | |||||.  |...|  .|  ....|   .|..   | .||
kdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvek.kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw

PEEGAEVYH
 |   . ..
qelsysnit
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 988-1105 1.6e-08 27.7 In-house 30-111 (169) alignment 
Range on Protein: 988-1105
Range on HMM: 30-111/169.0
LNRPGAPLPYDHSRVVLNHLANAEGLDYVNAstitdhdprapayvaaqgplpstlahfwQMIWEQGAVVIVALCRLQENgevacARYWPEEgaEVYHIYE
 ||| .||   | || |... .  | ||.||                            .||||  | ||| |   ..        .|||   | | .. 
knrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtddk.....nnfwpek..edyqlhp

VHLVSEHiWCDDYLVRSF
  .. |  . |   ||. 
avilgew.ytdslyvrtd
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 988-1105 2e-08 27.3 In-house 29-110 (169) alignment 
Range on Protein: 988-1105
Range on HMM: 29-110/169.0
LNRPGAPLPYDHSRVVLNHLANAEGLDYVNAstitdhdprapayvaaqgplpstlahfwQMIWEQGAVVIVALCRLQENgevacARYWPEEgaEVYHIYE
 ||| .||   | || |... .  | ||.||                            .||||  | ||| |   ..        .|||   | | .. 
knrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtddk.....nnfwpek..edyqlhp

VHLVSEHiWCDDYLVRSF
  .. |  . |   ||. 
avilGew.ytdslyvrtd
Phage_Nu1 Phage DNA packaging protein Nu1 1192-1235 8.5e-07 15.0 Pfam-A 94-138 (164) alignment 
Range on Protein: 1192-1235
Range on HMM: 94-138/164.0
ATLEHLRD-QRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSG
|. . |.  ..   |.  ....|||  ||.|. .||. .| ..  
adaqeLknakekkevvetelvtfvLsRvaaeiasiLdgiPlsvqr
subfamily_PTPDC1_pd Subfamily PTPDC1 1093-1214 1.4e-06 22.9 In-house 58-168 (182) alignment 
Range on Protein: 1093-1214
Range on HMM: 58-168/182.0
EHIWCDDYLVRSFYLKNLRTSETRTVTqFHFLSWPHMGVPAQaKALLDFRRKVNKSYRGRrscPIVVHGSAGAGRTGVYILLDLVLERmnkgarEIDIAA
||  |   | .| .  .|     . .. .. ..|.  ||..  . .||  . |. . .      . ||  || ||||| |   ||  .      ... . 
ehasCGagleesGfsYdlealmeqgiy.vynfgwkDygvasl.eriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyak......rltaek

TLEHLRDQRAGVVATRQQFEFV
... .|..|.  . ||.| |.|
aiklvrskrpksiqtreqvelv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1147-1191 3e-06 20.8 In-house 258-305 (349) alignment 
Range on Protein: 1147-1191
Range on HMM: 258-305/349.0
KSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLE---RMNKGAREIDIA
. .   .. ...|| ||| |||||.. |||.|.    ...    |.. 
lyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklq
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 995-1091 9.3e-06 20.0 In-house 3-83 (130) alignment 
Range on Protein: 995-1091
Range on HMM: 3-83/130.0
LPYDHSRVVlnhlanaeGLDYVNASTITDHDpRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEvacarYWPEegAEVYHIYEVHLV
|... ||.         | .|.||| .   . |.  |. .| ||  |  .||.|. |.   |.| |  ..|. |     |||.  .| .. || ...
lefevsrlq........gntyinasfvGllg.rtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpd..sePlewyeedii