Gene CG5577 in Drosophila melanogaster

Synonym: Dmel\CG5577, Dmel_CG5577, CG5577

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily PGP
Protein sequence
ID Type Fasta BLAST phosphatome Note
DmelP079_AA protein Get Run
DmelP079_AA_24-314 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PGP_pd Subfamily PGP 26-314 1.2e-97 317.6 In-house 1-278 (279) alignment 
Range on Protein: 26-314
Range on HMM: 1-278/279.0
TVLCDGDGTIWQDDTAIAGAPDVVNALQdRFDKKVYLITNNGLKTRQELFERSQRLGFHLPSDRHIISPTAAIADYLVGspkfDRTRHKVYVVGNAAIAR
|||.|.||..|...||| ||....|||. ...|||...|||..|.|.||... ..|||.  ....|.|..|||||||      .....||||.|......
tvlfDcDGVlWlgetaipgaaealnaLk.klgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkq....kkfekkvyvlgeeglke

ELRQRGIDSYGAGGTDELPPGDkwPDFVTREFGNPeaakDVGAVVVGWDEYFSYCKMARACHILCSNPdAAFLVTNRDAVHKYPS-FCIPGTGAFVAGIE
||...||...|.| ... .. |  .|||.. . ..    ||||||||.||..||.|...|...|...  ..||.||.||...... ..|||.|..|| ||
eLkeagiellgtgpeklkdeld..edfveelkldk....dvgAVvvgvdeklsyakllkAanyLrepe.vlflatneDallplkkevvipgaGslvaaie

ACSEREALEMGKPNPLVLEPFIKAEGLRTERTLMIGDCLKIDVGFASNCGMLSLLVGTGRYNnLSDVRLEKDR-LPQPDFYLPRLGDLLNI
|.|.|..| .||||.|.|| ....| ...||||||||.|| |. |..|||. .|||..| .. |.||. .|..  ..||.||..|.|||..
aasgrkplvlGKPnelllelllekeeidpertlmiGDrlktDilfgkncGlqtLlvlsGvtk.ledveeikkeeklvPdyyldsladllel
Chronophin_1 25-313 1e-56 183.3 In-house 2-257 (261) alignment 
Range on Protein: 25-313
Range on HMM: 2-257/261.0
DTVLCDGDGTIWQDDTAIAGAPDVVNALQDRfDKKVYLITNNGLKTRQELFERSQRLGFHLPSDRHIISPTAAIADYLVGspkfDRTRHKVYVVGNAAIA
..||.| || ......|..||.....||... .|.|  .|||  .||.|| .| .|||..  .  .|.| ..| | .|       ... ||||.|.. . 
qlvLlDldGVlikgeeavpgAaeliealkqa.gkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrq....qaakakvyvlGeeglr

RELRQRGIDSygAGGTDElppgdkwpdfvtrefgnpeaakDVGAVVVGWDEYFSYCKMARACHILcSNPdAAFLVTNRDAVHKYPSFCIPGTGAFVAGIE
.|||. |.    ......                      .| |||||.|| .|. |.|.|.. . ... | |..||||  .  ..  .||||. .| .|
kelreaGlrl..vdeped......................rveaVvvGydeelsfeklaeaiali.rdg.alfvatnrDptvPleeGiaPgtGslaaave

ACSEREALEMGKPNPLVLEPFIKAEGLRTERTLMIGDCLKIDVGFASNCGMLSLLVGTGRYNNLSDVRLEkdRLPQPDFYLPRLGDLLN
| |.||.| .|||.|.  |   .  |...|.|.|.|| |  |. .....|. .||| ||  ..    . .  .  .||...  . |||.
aAsgreplvvGKPepvmfeealekigadpeetvmvGDRldTDilagaraglstllvltGvseleeaqayk..kdlrPdavvesiadlle
Chronophin_2 26-314 1.3e-47 153.4 In-house 2-279 (282) alignment 
Range on Protein: 26-314
Range on HMM: 2-279/282.0
TVLCDGDGTIWQDDTAIAGAPDVVNALQdRFDKKVYLITNNGLKTRQELFERSQRLGFHLPSDRHIISPTAAIADYLVGspkFDRTRHKVYVVGNAAIAR
.|| | || ||. ..|.||||.||. |. |  |.| ..|||  ..|... ..  ||||      .|.| .   | ||       . | ||.|.|   . .
nvlfdcdgviwngekavagapevvsrla.ragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrd...vadvrgkvfviggeglrk

ELRQRGIDSYGAGGTDElppgdkwpdfvTREFGNPeAAKDVGAVVVGWDEYFSYCKMARACHILcSNPDAAFLVTNRDAVHKYPSF-CIPGTGAFVAGIE
|||. |.   .    .|           .  .  .  . || ||.||.|| ... |.|.||  |  ..|  .| |.||  |   .   .||.|.. | .|
elreagvpvvedadeqe...........asiydca.ldpdvravlvgydekltflklakacayl.rdadclllatdrdpwhplsdgritpgsgsltaale

ACSEREALEMGKPNPLVLEPFIKAEGLRTERTLMIGDCLKIDVGFASNCGMLSLLVGTGRY-----NNLSDVRLEKDRLPQPDFYLPRLGDLLNI
. | |.|. .||| . ..|   .   .   |.||||| |. |. | ||||. ..|  ||       .. || .| ..|   ||...  . |||. 
tasgrkatvigkpsrfmfecissqfsvdparslmigdrletdilfgsncglstvltltgvssleeaqeysdsqlaeqrdlvpdyvvesiadllea
subfamily_LHPP_pd Subfamily LHPP 27-286 1.1e-31 101.5 In-house 1-222 (227) alignment 
Range on Protein: 27-286
Range on HMM: 1-222/227.0
VLCDGDGTIWQDDTAIAGAPDVVNALQDRfDKKVYLITNNGLKTRQELFERSQRLGFHLpSDRHIISPTAAIADYLVGSPKfdrtrHKVYVVGNAAiARE
|| |  |.....|.||.|| .... |...  .|| ..||.  .....| || .||||.. .   |.....|....|  .       .....| ...   .
vllDlsGvlhnedaaipgavealkrLrqa.gvkvrfvtNttkeskralverLirlgfdv.eeeeiftsleaarqllrerkl.....rpyllveddv.eed

LRQRGIDSYgaggtdelppgdkwpdfvtrefgnpeaakdvGAVVVGW-DEYFSYCKMARACHILCSNPDAAFLVTNRDAVHKYPSFCIPGTGAFVAGIEA
. .   |.                                 |||.|  .| |.| .. .| ..|  ...|  .  |.. ..| ..  . | ||||...| 
fedidtdkp...............................navviglapesfeyetlnqafrllleakkakliainkgkyykrkdGlalgpGafvkaley

CSEREALEMGKPNPLVLEPFIKAEGLRTERTLMIGDCLKIDVGFASNCGMLSLLVGTGRYN
  . .|  .|||..|. |  ... |. .|. .|||| .. ||. | ..|. ..|| ||.. 
atgvkaevvGKPsalffekaleelgvdpeeavmiGDdvedDveGAlkaGlrgvlVktGkfr
Hydrolase_6 Haloacid dehalogenase-like hydrolase 27-132 3e-25 79.6 Pfam-A 1-100 (101) alignment 
Range on Protein: 27-132
Range on HMM: 1-100/101.0
VLCDGDGTIWQDDTAIAGAPDVVNALQDRfDKKVYLITNNGLKTRQELFERSQRLGFHLPSdRHIISPTAAIADYLVGSPKfdrtRHKVYVVGNAAIARE
.|.| ||..|..|.|| ||.....||...  |.|.|.|||. |...|. .. ..||...    .....  |.|.||   ..    ..||.|.|. ....|
flfDvdGvLwrgdkaipgaaealkalraa.gkpvvllTNnsskseeeyakkleklgvdvte.eqvvtsataaaeylkkrka....dkkvlvigeeglree

LRQRGI
|.. |.
lkeaGf
Hydrolase_like HAD-hyrolase-like 234-310 4.6e-13 40.2 Pfam-A 2-74 (75) alignment 
Range on Protein: 234-310
Range on HMM: 2-74/75.0
MGKPNPLVLEPFIKAEGLRTERTLMIGDCLKIDVGFASNCGMLSLLVGTGRYNNlsdVRLEKDRlPQPDFYLPRLGD
.||||| ...   .  |.. ....|||| |  |. .| |.|. |.|| || ...    .|...  ..||.... | .
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsre...edlklak.akpdyvvddlee
Hydrolase haloacid dehalogenase-like hydrolase 25-272 5.5e-08 24.8 Pfam-A 2-213 (215) alignment 
Range on Protein: 25-272
Range on HMM: 2-213/215.0
DTVLCDGDGTIWQDDTAI--AGAPDVVNALQDR-------FDKKVYLITNN-GLK-TrqelfersqR------LGFHLPSDRHIIsptaaiadYLvGSPK
.||. | .||..    ..  .|.  . .....        ..|.|  .. .  .. .                 |     .. .|        .| | |.
ktvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstrgg.........ltgfatfigrgvsgkvdgi........vl.gnpe

FDRTRHKVYVVGNAAIARELRQRGIDSYGAGgtdelppgdkwpdfvtrefgnpeaakDVGAVVVGWDEYFSYCKMARACHILCSNPDAAFLVT--NRDAV
  .   . .  .  . | . ......   |                           .. |. |  ..   . ..| |.. | ..    .|.|  |....
wmtalglrviapdlvaaegqskgrtvvvvav..........................qaralgviafadpvkpeaaeavasLkeaGievvlltgdnpeta

HKYPSFCIPGTGAFVAGIEacserealemGKPNPLVLEPFIKAEGLRTERTLMIGDCLkIDVGFASN
..  ..    . ...|.            |||.| ...  |.. ..  ....|.|| .  |. .. .
eaiakqagiedslvfaevv..........gkPepklfvaaieeLqidpgevamvGDgv.nDapalaa