Gene CDC14A in Homo sapiens

Synonym: cdc14, hCDC14, CDC14A

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDC14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP005_AA protein Get Run
HsapP005_AA_16-159 phosphatase_domain Get Run
HsapP005_AA_178-336 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_CDC14_pd Subfamily CDC14 17-337 4.7e-180 592.5 In-house 8-328 (328) alignment 
Range on Protein: 17-337
Range on HMM: 8-328/328.0
SDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAY
.|||||||||..|||| ..||||.|.||.||||||||||||||..||||.|||||||| . ..||||.||..|..||||||.|||||||||||||.||||
edrlyfatlrkkPkstselhyfsvddelkyenfyadfGPlnlavlyrycvklnkkLkseekaskkivlytsadskkranaalligayaviylkktaeeay

RALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPY
||| ....||..||||||.|...|.||.||.|.|..|.||.||.|.|.||..|||.||||||||||||||.||||..|||.|||.|.||||||||....|
raleaaetppfvpfrdasygsasykltlldvlkgvekalqkgfldledfdleeYekyervenGDfnwivPdkflalagPhnkskledgyplhaPeklley

FKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGS
|.|.|||.|||||||.|.||.||||||.|.||||||||||||.||..||.|.|..||||||||||||||||||||||.|||||||.||.|||.|||||||
frknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGs

IIGPQQHFLEEKQASLWVQGD
.|||||.|||||||.||..||
vigpqqkfleekqaalwlegd
DSPn Dual specificity protein phosphatase, N-terminal half 17-153 2.4e-63 203.0 Pfam-A 5-140 (141) alignment 
Range on Protein: 17-153
Range on HMM: 5-140/141.0
SDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAY
 |||||..|...||.| ||||||||||||||.|||||||||||..||.|.|||||||. .|..||||.||..|..||||||.||||||||.||..||||.
edrLyfvslkkkpkktenthyfsiDeelvYepfyadFGPlnlaqiyrfcvklnkkLkeaelkkkkivlytsldekkranaalLigaYavivlklspeeal

RALLSGSnPPYLPFRDASFGNCTYNLTILDCLQGIRK
..| |.. |..|||||||.|..||.|||||||.|..|
kplesve.psllpFrDAsygestyeltildclkglek
0048567 (Phosphotyrosine protein) phosphatases II 17-163 1.6e-57 188.0 In-house 12-157 (157) alignment 
Range on Protein: 17-163
Range on HMM: 12-157/157.0
SDRLYFATLRNRPKSTVNTHYFSIDEELVYENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAY
 ||||||.|.. |||..|..|||||..||||.|..||||||||..||...||||.||...| .|.|.........||...|.|||.|....|..|||||.
pdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeai

RALlSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFE
. | .  .|...||||||.....||||.||.|.|..|.|..||.|.|
apl.rivrpgsvpfrdasyllslynltlldvlyGllkAlelgfldle
0049772 (Phosphotyrosine protein) phosphatases II 126-333 1.6e-46 154.8 In-house 65-271 (314) alignment 
Range on Protein: 126-333
Range on HMM: 65-271/314.0
PYLPFRDASFGNCTYNLTILDCLQGiRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIVPGK---------------------FLAFSGPHpkskienG
|.||... .. |. |  ..|....  .. |.....||....| .|.....|..||.|......                     .| ..|..       .
pglpvsgsdyinasyvdgflkfIat.qgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.......n

YPlhaPEAYFPYFKkhnvtavvrlnKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICEN--TEGAIAVHCKAGLGRTGT-LIACYVMKHYRFT
.|   ..|.....|           . .|....|...|...... . |||.|.......||...|.  ..|...|||||| ||||| ..|.|.||.....
ep...taadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvs

HAEIIAWIRICRPgsiIGPQQHFLEEKQASLW
 .|.....| .||   |.|...|.|  .  ..
leealedvrlkRp...inpnpgfieqleqyef
0041856 (Phosphotyrosine protein) phosphatases II 165-341 4.6e-45 148.8 In-house 2-178 (182) alignment 
Range on Protein: 165-341
Range on HMM: 2-178/182.0
FDVDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRF
.| ..|... ..... ... .  .....| |. .  . .|..|. ........|....|..|.|.   | .......|.....|.. |...|. ... .|
ldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldf

LNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRS
...... .|...|||.||.||||||.|.|.||.....  |.....| .|||..| |.|.|..  .. ........|.
ieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkktrp
0038934 (Phosphotyrosine protein) phosphatases II 168-328 1.4e-44 147.4 In-house 4-169 (194) alignment 
Range on Protein: 168-328
Range on HMM: 4-169/194.0
DEYEHYERVENgdfnwIVPGKFLAFSGPHPKSKIENGYPLH--APEAYFPYFKKH--NVTAVVRLN--KKIYEAKRFTDAGFEHYDLFFID-GSTPSDNI
|....||||..     |..|.|.||..|...|  .. ..|.  .|| .. |.| .  ....|..|.  .. |....|..||.|...|.|.| |..||..|
drwlkyervgd.....iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPslei

VRRFLNIC-----ENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIigPQQHFLEEK
..|||...     |...|..||||||||||||||.|.| .......  | ||..|..|||.|  |.|..||. 
llrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai..pnqdyleal
0050432 (Phosphotyrosine protein) phosphatases II 121-324 1.3e-42 141.6 In-house 5-289 (308) alignment 
Range on Protein: 121-324
Range on HMM: 5-289/308.0
SGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFD------FETFDVDEYEHYERVENGDFNW-------------------------------
..  ...|.|||.|. .....|..||.|. . | |. |...      ...... ||......||.|.|.                               
ldallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyss

IVPGKFLAFSGPHpkskiengypLHAPEAYFPYFKKHNVTAVVRLNKKIYE-----AKRFTDA---GFEHYDLFFI------------------------
..| ||.|. ||.           .  | .. .. ..||. .|.|.| ..      |. . .    |...|. |..                        
klprkfIatqgPl..........pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg

--------------DGSTPSD-NIVRRFLNICENT--EGAIAVHCKAGLGRTGTLIACYVM-----KHYRFTHAEIIAWIRICRPGSIIGPQQHF
              |...|.. .|. .||......  .| |.|||.||.|||||.||....     |.....  |.....| .|||....|.|..
esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqyl
0045450 (Phosphotyrosine protein) phosphatases II 124-323 1.5e-40 135.2 In-house 2-293 (307) alignment 
Range on Protein: 124-323
Range on HMM: 2-293/307.0
NPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQhGFFDFETFDVDEYEHYERVENGDFNWI---------------------------------------
..|. .|.|| .. . ..|..||.|.|..|  .  ......|...||......||.|.|..                                       
dlplslfidalkllllvllllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvplllll

----VPGKFLAFSGPHPKskiengyplhAPEAYFPYFKKHNVTAVVRLNKKIYEAKR------------------------------------------F
    .. ||.|. ||.|.           .| .. ......||..|.|.. .. ...                                          .
dgydlkrkfIatqgPlpe..........tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldg

TDAGFEHYDLFF---IDGSTPSD-NIVRRFLNICEN------TEGAIAVHCKAGLGRTGTLIACYVMKHYR--------FTHAEIIAWIRICRPGSIIGP
|. ..... ...    |...|.. ... .|......       .| ..|||.||.|||||.||.|.|....        ..  |.....| .|||..  |
tgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

QQH
.| 
eqy
0040438 (Phosphotyrosine protein) phosphatases II 138-322 1.6e-40 134.7 In-house 3-264 (317) alignment 
Range on Protein: 138-322
Range on HMM: 3-264/317.0
CTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIV----------------------------------PGKFLAFSGPHPKskien
. ..|..||.|..  ..|. .|.|. ....|.|...|..||.|.|...                                  . ||.|..||.|.     
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpn.....

gyplhAPEAYFPYFKKHNVTAVVRLNKKIYE------------------------AKRFTDAGFEHYDLFF-------------------IDGSTP-SDN
       | .. ......|| .|.|..  .                          . ...||.... | .                    |...| | .
.....tvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspd

IVRRFLNICENT----EGAIAVHCKAGLGRTGTLIACYVM-----KHYRFTHAEIIAWIRICRPGSIIGPQQ
.. .||.....     .| ..|||.||.|||||.||.|.|     |.....  |.....| .|||..  |.|
llldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeq
0039614 (Phosphotyrosine protein) phosphatases II 127-323 5e-40 133.2 In-house 1-278 (297) alignment 
Range on Protein: 127-323
Range on HMM: 1-278/297.0
YLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFDV----DEYEHYERVENGDFNWIV------------------------------------P
|||.|||....... |..||.|....| .. .... | ...    ..|......||.|.|...                                    .
ylplrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydllt

GKFLAFSGPHPKskiengyplhAPEAYFPYFKKHNVTAVVRLNKKIYEAK----------------------RFTDAGFEHYDLFF--------------
 ||.|..||.|.           .| .. ......||..|.|.| ..  .                       ....|. .. |                
rkfIatqgPlpe..........tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqy

---IDGSTP-SDNIVRRFLNICEN------TEGAIAVHCKAGLGRTGTLIACYVM-----KHYRFTHAEIIAWIRICRPGSIIGPQQH
    |...| | ... .||.....       .| ..|||.||.|||||.||.| |     |.....  |.....| .|||..  |.| 
tgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqy
0045098 (Phosphotyrosine protein) phosphatases II 152-334 3e-39 130.5 In-house 7-273 (278) alignment 
Range on Protein: 152-334
Range on HMM: 7-273/278.0
RKGLQHGFFDFETFDVDEYEHYERVENGDFNWIV----------------------PGKFLAFSGPHPkskiengyplHAPEAYFPYFKKHNVTAVVRLN
 . |. ..| . .....|.... ...|.|.|...                      | ||.|. ||.|          .  .... .......|..|.|.
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlp..........stvadfwrmlwelgitvivmlt

KKIYEA----------------------------------------------KRFTDAGFEHYDL-FFIDGSTPSDNIVRRFLNICE-------------
. .. .                                              . .. .|..|... .. |...||..|.. ||...|             
elvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasll

-------NTEGAIAVHCKAGLGRTGTLIACYVMKHY---RFTHAEIIAWIRICRPG-SI-IGPQQHFLEEKQASLWV
       . .| ..|||.||.||||||.|.| |...   ...  |.....| .||| .. .  |..||.| .. |. 
lsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0044763 (Phosphotyrosine protein) phosphatases II 160-337 1.7e-38 127.4 In-house 2-175 (178) alignment 
Range on Protein: 160-337
Range on HMM: 2-175/178.0
FDFETFDVDEYEHYERVENGDFNWIVPGKFLAFSGPhpkskiengyplhapEAYFPYFKKHNVTAVVRLNKKIY------EAKRFTDAGFEHYDLFFIDG
.|.  ......|..||... ....|.|| .|.  .|               .......|....|..|.|.. ..       .. ...||.... . . |.
ldrtrvllsnleglersdyinaseilpglylgslpp...............addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDh

STPS-DNIVRRFLNICE----NTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGD
..|. . ....|....|    . .|...|||.||.||.|||.|.| ||.....  |.|...| .||...   |...|.| .  |. ..|
gvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllkesd
0043336 (Phosphotyrosine protein) phosphatases II 137-322 2.4e-38 127.6 In-house 4-265 (278) alignment 
Range on Protein: 137-322
Range on HMM: 4-265/278.0
NCTYNLTILDCLQGIRKGLQHGFFDFETFDVDEYEHYERVENGDFNWIV----------------------------------PGKFLAFSGPHPKskie
 ...  ..|..| . ...|. .|... .|..|.|......||.|.|...                                  | ||.|..||.|.    
vkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe....

ngyplhAPEAYFPYFKKHNVTAVVRLNKKI--------------------------------------------YEAKRFTDAGFEHYDLFfiDGSTPSD
       .| .. ......|| .|.|..                                              .. . .|  .. ...    |...|..
......tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpes

-----NIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVM-----KHYRFTHAEIIAWIRICRPGSIIGPQQ
     ..........|. .|...|||.||.|||||.||.|..     |.....  |.....| .|||..  |.|
lsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsq
0048567 (Phosphotyrosine protein) phosphatases II 215-333 2.8e-37 122.4 In-house 10-138 (157) alignment 
Range on Protein: 215-333
Range on HMM: 10-138/157.0
PYFKKHNVTAVVRLNKKIYEAKRF-TDAGFEHYDLFFIDGstPSD--------NIVRRFLNICENTEGAIAVHCKAGL---GRTGTLIACYVMKHYRFTH
 ...........||.|..|.|. | .|.|. ..|.|| .|  | .        ... .||.|.|....||||||||||   |||.|||.|| ..|..|| 
iipdrlyfallprlpkslynalyFsiddglvyedfffdfG..PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftp

AEIIAWIRICRPGSIIGPQQHFLEEKQASLW
.|.||..||.||||........|. ..  ..
eeaiaplrivrpgsvpfrdasyllslynltl
0043147 (Phosphotyrosine protein) phosphatases II 168-326 5.9e-36 119.1 In-house 2-153 (172) alignment 
Range on Protein: 168-326
Range on HMM: 2-153/172.0
DEYEHYERVENGDFNWiVPGKFLAFSGPhpkskiengyPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNI
||...|..... |... .| .|.|. ||            .  . .. ..|....|..|.|..  | .. ... |.... | . |...|. .....||..
degsdyinasyldlyy.ipdrfiatqgp..........lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflef

CEN-----TEGAIAVHCKAGLGRTGTLIACYVMKhYRFTHAEIIAWIRICRPGSIIGPQQHFLE
...      .|...|||.||.||||||.|.| |. ....  |..|..| .|||..  |.|. . 
idellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrfl
0051082 (Phosphotyrosine protein) phosphatases II 180-326 1.6e-33 110.8 In-house 7-145 (151) alignment 
Range on Protein: 180-326
Range on HMM: 7-145/151.0
DFNWIVPGkFLAFSGPHPkskiengyplhapeAYFPYFKKHNVTAVVRLNKKI---YEAKRFTDAGFEHYDLFFIDGSTPSD----NIVRRFLNICENT-
.|... .| .....||..              ......|.......| |...    |........|.|.... ..| ..|.     ..|..||...... 
nfsyvtgg.lyrsggpla..............dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkk

EGAIAVHCKAGLGRTGTLIACYVMKhYRFTHAEIIAWIRICRPGSIIGPQQHFLE
.| ..|||.||.||||||.|.| |. .... .|.....|..|||... .||....
ngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfq
0049260 (Phosphotyrosine protein) phosphatases II 208-326 9.2e-33 108.4 In-house 20-142 (152) alignment 
Range on Protein: 208-326
Range on HMM: 20-142/152.0
HAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNI-----CENTEGAIAVHCKAGLGRTGTLIACYVMKhYRFTH
.  . .. ..|....|..|.|..  . .| ... ..... |.. |...|.. .. .||..     ... .| ..|||.||.||||||.|.| |. .... 
ntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsl

AEIIAWIRICRPGSIIGPQQHFLE
 |..|..| .|||... |.| .. 
eeavalvrekRpgavpnpgqlrfl
0040439 (Phosphotyrosine protein) phosphatases II 169-322 1.1e-32 109.0 In-house 2-234 (249) alignment 
Range on Protein: 169-322
Range on HMM: 2-234/249.0
EYEHYERVENGDFNWIV----------------------------------PGKFLAFSGPHPKskiengyplhAPEAYFPYFKKHNVTAVVRLNKKI--
||......||.| |...                                  . .|.|..|| |.          . |... .......|..|.|..    
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe..........tvedfwrmlwelgitvivmLtslvel

-------------------------------------------YEAKRFTDAGFEHYDLFfiDGSTP-SDNIVRRFLNICEN------TEGAIAVHCKAG
                                           |. . .|  .. ..|.   | ..| | ... .|......      ..| ..|||.||
grekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaG

LGRTGTLIACYVM-----KHYRFTHAEIIAWIRICRPGSIIGPQQ
.|||||.||.| |     |.....  |.....| .|||..  |.|
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeq
0042113 (Phosphotyrosine protein) phosphatases II 170-323 2.9e-32 107.4 In-house 1-232 (245) alignment 
Range on Protein: 170-323
Range on HMM: 1-232/245.0
YEHYERVENGDFNWI----------------------------------VPGKFLAFSGPHPKskiengyplhAPEAYFPYFKKHNVTAVVRLNKKIYE-
|......||.|.|..                                  ...||.|..||.|.           .|... .......|..|.|..  .  
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe..........tvedfwrmlwelgittivmLteeeelg

------------------------------------------AKRFTDAGFEHYDLFFIDGSTPS-DNIVRRFLNICEN-----TEGAIAVHCKAGLGRT
                                           . ..  .. .. | . |...|. .... .||.....      .| ..|||.||.|||
rvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt

GTLIACYVM-----KHYRFTHAEIIAWIRICRPGSIIGPQQH
||.||.| |     |.....  |.....| .|||..  |.| 
GtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqy
PTEN_1 169-332 5.4e-32 106.2 In-house 13-191 (196) alignment 
Range on Protein: 169-332
Range on HMM: 13-191/196.0
EYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGY--PLHAPEAYFPYFKKHNVTAVVRLNK------KIYEAKRFTDAGFEHYDLFFIDGSTPSDNI
 ... | .... ... . ... |.| | ..  .|. |  .|. ..|..  .|....|.||.|.       . |. . | . |.|.... . |  .|| . 
lalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslse

VRRFLNICENT------EGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICR-PGSIIGPQQHFLEEKQASL
. .... ...       .....|||||||||.||..|.| |.....|  | ....|..| ||..  |.|  |.| .|.|
lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
0037934 (Phosphotyrosine protein) phosphatases II 176-322 5.5e-32 106.7 In-house 34-230 (243) alignment 
Range on Protein: 176-322
Range on HMM: 34-230/243.0
VENGDFNWIVPgKFLAFSGPHPKskiengYPLHAPEAYFPYFKKHNVTAVVRLNKKI------------------------------------------Y
  |... ...| .. |..||.|.         ....... .......|..| |.. .                                          .
yinanliyvtp.rliatqgPlpe......tveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenl

EAKRFTDAGFEHYDLFFIDGSTPS-DNIVRRFLNI------------CENTEGAIAVHCKAGLGRTGTLIACYVMKHY-RFTHAEIIAWIRICRPG-SII
... .|  .. .. | . |...|.  ... .||..            .....| ..|||.||.||||||||.|.|... ...  |.....| .||| .. 
dlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavq

GPQQ
 |.|
tpsq
0036282 (Phosphotyrosine protein) phosphatases II 172-323 7.6e-32 105.8 In-house 3-159 (174) alignment 
Range on Protein: 172-323
Range on HMM: 3-159/174.0
HYERVENGDFNWIVPgKFLAFSGPHPkskiengyplhapeaYFPYFKKHNVTAVVRLNKKIYEA------------KRFTDAGFEHYDLFFIDGSTPSDN
.|... . |...| | ...|..||..               .....|....|.||.|.. ..              . ... |.....| . |...|...
dyinaspldlsyitp.rliagqgpla...............fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdls

IVRRFLNICENT-----EGAIAVHCKAGLGRTGTLIACYVMKHYRF-THAEIIAWIRICR---PGSIIGPQQH
|...|....|.      .| ..|||.||.||||||.|.| |... . .  ......| .|   ||... |.| 
illefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQy
0046846 (Phosphotyrosine protein) phosphatases II 175-323 1e-29 98.9 In-house 6-162 (176) alignment 
Range on Protein: 175-323
Range on HMM: 6-162/176.0
RVENGDFNWIVPGKFLAFsgphpKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKK--------IYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLN
.....|...|... .|       .  .  |   .  .... ..|....||||.|..          .  ......|.... | . |...|..... ..|.
lgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllelle

ICENTE---GAIAVHCKAGLGRTGTLIACYVMKH-YRFTHAEIIAWIRICRP-GSIIGPQQH
....     | ..|||.||.||||||.|.| ... . ..  |..|..| .|| |..  |.| 
firealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQy
0047943 (Phosphotyrosine protein) phosphatases II 163-323 2.3e-28 94.8 In-house 23-261 (273) alignment 
Range on Protein: 163-323
Range on HMM: 23-261/273.0
ETFDVDEYEHYERVENGDFNWI------------------------------VPGKFLAFSGPHPKSkiengyplhaPEAYFPYFKKHNVTAVVRLNKKI
..... .|......||.|.|..                              .. ||.|. || |..           | .. .....||. .|.|.. .
slkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpnt..........vedfwrmvweqnvrviVmLtelv

YEAKR-----FTDAG---FEHYDLFFI--------------------------------------DGSTP-SDNIVRRFLNICEN------TEGAIAVHC
.  ..     . . |   .. |. |..                                      | ..| | ... .|......       .| ..|||
elgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHC

KAGLGRTGTLIACYVM-----KHYRFTHAEIIAWIRICRPGSIIGPQQH
.||.|||||.||....     |.....  |.....| .|||... |.| 
saGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqy
0048179 (Phosphotyrosine protein) phosphatases II 213-324 4.8e-28 93.1 In-house 21-136 (144) alignment 
Range on Protein: 213-324
Range on HMM: 21-136/144.0
YFPYFKKHNVTAVVRLNKKiYEAKRFTDAGFEHYDLFFIDGSTPSD-NIVRRFLNICENT---EGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAW
 ....||...|.|..|. . ||   ... |.... | . | ..|.. .....||...|.    .| ..|||.||.||||||.|.|.||.....  |..|.
dlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealal

IRICRPGSIIGPQQ-HF
.| .|||... |.| .|
vrsrrpgavpnpgqlrf
0048076 (Phosphotyrosine protein) phosphatases II 214-325 2.4e-27 90.8 In-house 22-135 (145) alignment 
Range on Protein: 214-325
Range on HMM: 22-135/145.0
FPYFKKHNVTAVVRLnkkIYEAKRFTDAGFEHYDLFFIDGSTPSD-NIVRRFLNICENT---EGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWI
....|....|.|..|    .| . ... |.... | . | ..|.. .....||...|.    .| ..|||.||.||||||.|.|.|......  |.....
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelv

RICRPGSIIGPQQ-HFL
| .|||... |.| .||
rsqrpgavpnpgqlrfl
0046845 (Phosphotyrosine protein) phosphatases II 183-323 2.9e-22 74.8 In-house 73-263 (284) alignment 
Range on Protein: 183-323
Range on HMM: 73-263/284.0
WIVPGKFLAFSGPHPKskiengyplhAPEAYFPYFKKHNVTAVVRLNKKIYE-----------------------------------AKRF-------TD
.... ||.|..|| |.            | ..    ..||. .| |.. .                                       ..       |.
tyikkkfIatqgPlpn..........tvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytg

AGFEHYDLFFI---DGSTP-SDNIVRRFLNICENT------EGAIAVHCKAGLGRTGTLIACYVMKHY--------RFTHAEIIAWIRICRPGSIIGPQQ
  .... . ..   | ..| | ... .||.....       .| |.|||.||.|||||.||.......        ...  |.....| .|||..  ..|
esrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleq

H
 
y
0051299 (Phosphotyrosine protein) phosphatases II 185-323 1.4e-21 72.6 In-house 90-275 (288) alignment 
Range on Protein: 185-323
Range on HMM: 90-275/288.0
VPGKFLAFSGPHPkskiengyplHAPEAYFPYFKKHNVTAVVRLNKKI------------------------YEAKRFTDAGFEHYDLFFI---------
 . ||.|. || |          .  | .. .  ..||. .|.|.| .                        .  .  ..... .. |            
lkrkfIatqgPlp..........ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdg

--------------DGSTPS-----DNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVM-----KHYRFTHAEIIAWIRICRPGSIIGPQQH
              | ..|.      ...|.. . .....| ..|||.||.|||||.||....     |.....  |.....| .|||... |.| 
esrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqy
0051429 (Phosphotyrosine protein) phosphatases II 181-323 3.9e-21 71.4 In-house 16-214 (272) alignment 
Range on Protein: 181-323
Range on HMM: 16-214/272.0
FNWIVPGKFLAFSGPHPKSkiengyplhapEAYFPYFKKHNVTAVVRLNKKIYEAK---RFTDAGFEHYDLFFIDGSTPSD-------------------
.....||.... .||.| .           .| |...|.......| | .  . ..    .  .|.... | ..| |.|.                    
grvvkpgrlyrsggplplt...........aadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyi

---------------------------------NIVRRFLNICENtEGAIAVHCKAGLGRTGTLIACYVMKhYRFT--------------HAEIIAWIRI
                                 . ....|... . .|.. |||.|| .||||..|.. .  ....               .|.....| 
lrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelra

CRPGSIIGPQQH
.|||..  ..| 
qrpgavqteeqy
subfamily_PRL_pd Subfamily PRL 212-330 1.4e-20 67.8 In-house 25-147 (151) alignment 
Range on Protein: 212-330
Range on HMM: 25-147/151.0
AYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNIC-----ENTEGAIAVHCKAGLGRTGTLIACYVMKHyRFTHAEII
 .   .||..|..|||  .  |... . ..| |  || | ||..|....|...|...     |... ..|||| |||||.  |.|  .. .  ... . .
kfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmkyedav

AWIRICRPGSIIGPQQHFLEEKQA
 .||  | |.|   | .|||. .|
efirekrrgainskqlkflekyka
0036941 (Phosphotyrosine protein) phosphatases II 186-323 9.5e-20 66.5 In-house 77-266 (297) alignment 
Range on Protein: 186-323
Range on HMM: 77-266/297.0
PGKFLAFSGPHPkskiengyplHAPEAYFPYFKKHNVTAVVRLNKKIYE---------------------------------AKRFTDAGFEHYD-----
. ||.|  || |          .  | ..    ..||| .| |.. .                                    . .|   .| .|     
krkfIatqgPlp..........ntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgnge

---------LFFIDGSTPS-DNIVRRFLNICEN------TEGAIAVHCKAGLGRTGTLIACYVM--------KHYRFTHAEIIAWIRICRPGSIIGPQQH
         .   | ..|.  ... .|.. ...       .| . |||.||.||.||.||...|        |.....  |.. ..| .|||..  ..| 
srtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqy
subfamily_DSP23_pd Subfamily DSP23 252-322 2.9e-16 54.4 In-house 61-134 (148) alignment 
Range on Protein: 252-322
Range on HMM: 61-134/148.0
DGSTPSDNIVRRFLNICENTE---GAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQ
|   |. . | .|... |..|    |..|||  | |||||..|||..|. ... || || .|  ||||.   .|
dyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveq
PTPc_motif_SM00404 216-327 9.7e-16 52.9 In-house 22-133 (140) alignment 
Range on Protein: 216-327
Range on HMM: 22-133/140.0
YFKKHNVTAVVRLNKKI---YEAKRFTDAGFEhYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRIC
  ||...|.|. . ...   .| ..|.    .  |    |  ..  . | .|.. .|...|.. |||.||. |..|||..|.|. . .. || .  ..  
llkklgithvinvteevsltkensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvker

RpgSIIGPQQHFLEE
|  .|| |. .|...
R..piispnlnfvrq
subfamily_PTPDC1_pd Subfamily PTPDC1 233-322 2.1e-15 51.6 In-house 73-164 (182) alignment 
Range on Protein: 233-322
Range on HMM: 73-164/182.0
YEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICEN--TEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQ
|. . ....|  .| . . | ...| . .     . .   .||..|||| ||||||| |||||.. . |.| .. |  .|  || ||   .|
YdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreq
DSPc Dual specificity phosphatase, catalytic domain 218-326 8e-14 46.7 Pfam-A 15-125 (133) alignment 
Range on Protein: 218-326
Range on HMM: 15-125/133.0
KKHNVTAVVRLNKKIY-----EAKRFTDAGFEHYDlFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRIC
.|...|.|. . |..      . ..... .    | .  .  ..  . . .|.. .|. .. ..|||.||. |..|||..| || ....  | .. ..  
eklgitlvinvtkevpnnnaikkseieylripved.etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvker

RpgSIIGPQQHFLE
|  |.| |. .|| 
r..skispnagflr
DSPc Dual specificity phosphatase, catalytic domain 218-326 8e-14 46.7 In-house 15-125 (133) alignment 
Range on Protein: 218-326
Range on HMM: 15-125/133.0
KKHNVTAVVRLNKKIY-----EAKRFTDAGFEHYDlFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRIC
.|...|.|. . |..      . ..... .    | .  .  ..  . . .|.. .|. .. ..|||.||. |..|||..| || ....  | .. ..  
eklgitlvinvtkevpnnnaikkseieylripved.etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvker

RpgSIIGPQQHFLE
|  |.| |. .|| 
r..skispnagflr
subfamily_RNGTT_pd Subfamily RNGTT 185-327 5.1e-13 43.1 In-house 14-166 (189) alignment 
Range on Protein: 185-327
Range on HMM: 14-166/189.0
VPGKFLAFSGPHP---KSKIENGYpLHAPEAYFPYFK--KHNVTAVVRLN--KKIYEAKRFTDAGFEHYDLFFI-DGSTPSDNIVRRFLNICEN-----T
. .|||.|  |     .... .    . |.  . |.|  |...  |. |   .. |... ... | ..  |     | .|. . |..| ...|.     .
iaekflpfktplskrydddlaeen.rfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknp

EGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIgpQQHFLEE
|  |.|||. |  ||| ||..|....  .   . .|  . .||  |   ....|.|
eevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiy..kedylke
subfamily_PTPMT1_pd Subfamily PTPMT1 217-315 1.8e-12 42.0 In-house 42-150 (171) alignment 
Range on Protein: 217-315
Range on HMM: 42-150/171.0
FKKHNVTAVVRLNKKiYE-------AKRFTDAGFEHYDLFFIDGS-TPSDNIVRR---FLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEI
..|.|| ||| ||.  ||        ....  | |.. |  .|   .|. . . .   |..   ..   . |||||| ||..||.|||.||.....  | 
iekenvkavvslnee.yelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeA

IAWIRICRPG
.  .. .|. 
lkalkkkRki
subfamily_DSP1_pd Subfamily DSP1 218-325 1.5e-10 35.4 In-house 40-146 (163) alignment 
Range on Protein: 218-325
Range on HMM: 40-146/163.0
KKHNVTAVVRLNKKIYEakRFTDaGFEHYDLFFIDGSTpSD-----NIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRIC
|....||.. . |.. .   | |  ||.. |   | ..  |     . |  |.. .....| . .||.||. |  ||.  |.||. |..  |   ...  
kslgitailnvskeldn..vfed.lfeYkklkleDspk.adislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqr

RpgSIIGPQQHFL
|  ||| |   | 
R..siisPnagFv
subfamily_DSP11_pd Subfamily DSP11 230-313 7.9e-10 32.9 In-house 67-157 (178) alignment 
Range on Protein: 230-313
Range on HMM: 67-157/178.0
KKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRR-------FLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICR
.. |. | .|| | ... |.    ..|....|..       ||. .....  |.|||  |. ||| ||  |....  .   . |     .|
dryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear
subfamily_PTEN_pd Subfamily PTEN 252-307 1.1e-09 33.6 In-house 89-150 (184) alignment 
Range on Protein: 252-307
Range on HMM: 89-150/184.0
DGSTPSDNIVRRFLNI-----CENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHA-EIIA
|  .|. ........       |...  ..|||||| ||||.||..|..|.  ...| |...
DhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeeale
subfamily_DSP12_pd Subfamily DSP12 263-326 3.4e-09 31.3 In-house 73-134 (155) alignment 
Range on Protein: 263-326
Range on HMM: 73-134/155.0
RFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPgsIIGPQQHFLE
.|.. . ..|||. |||.||. |  |... |.||....   . .  ..  .|   | | . |||
dFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkp..eiepNegFle
subfamily_DSP10_pd Subfamily DSP10 264-325 4.7e-09 30.3 In-house 84-143 (159) alignment 
Range on Protein: 264-325
Range on HMM: 84-143/159.0
FLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPgsIIGPQQHFL
|..   ...  . |||.||. |  |..  |.||| . .  .   ... .||  || |   |.
fieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp..iisPnLnfm
PTPc_DSPc_SM00012 260-298 5e-09 31.7 In-house 21-65 (105) alignment 
Range on Protein: 260-298
Range on HMM: 21-65/105.0
IVRRFLNICE-------NtEGAIAVHCKAGLGRTGTLIACYVMKHY
 . ..|. ..       . .. . |||.|| |||||..| ... . 
silellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqq
subfamily_DSP15_pd Subfamily DSP15 218-343 6.6e-09 30.0 In-house 24-147 (151) alignment 
Range on Protein: 218-343
Range on HMM: 24-147/151.0
KKHNVTAVVRLNKkiyEAKRFTDAgfEHYDLFFIDGsTPSDNIV------RRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRI
|..|.| .. ..    .||.. .    .| .. ..  ||| ..        .|.  |   |... ||| ||. |  ||.. |.|    . . ...  |. 
keknithilsvhd...nakkllkd..ieYkciaasD.tpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevika

CRpgSIIGPQQHFLEEKQASLWVQGDIFRSKL
.|  |.  |   | .  .   . . . .| .|
aR..svanPnfGfkrqlkeyektklkeyrkql
subfamily_DSP19_pd Subfamily DSP19 218-326 6.8e-09 30.2 In-house 34-141 (152) alignment 
Range on Protein: 218-326
Range on HMM: 34-141/152.0
KKHNVTAVVRLNKKIYEA--KRFTDAGFEHYDLFFIDGSTPSDNiVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPG
|....| .. .  .. ..  | ||    | .||   | ..  .. .  |..   ...||. |||.||  |. ...  |.||. . .  | .  .|  || 
kekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylke.aldFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpc

siIGPQQHFLE
  | | . |..
..ikPneGFik
subfamily_DSP3_pd Subfamily DSP3 226-326 1.6e-08 28.3 In-house 51-148 (162) alignment 
Range on Protein: 226-326
Range on HMM: 51-148/162.0
VRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPgsiIGPQQHFL
|  ... |.   ..  |.|  | . .| |.  .. ..   .  ...|| . |||..|. |  ||.  |.| . ..|  | |  .|  |    |.| . ||
vdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkRe...ilPneGFl

E
.
k
subfamily_Slingshot_pd Subfamily Slingshot 262-327 3.4e-08 27.0 In-house 86-149 (169) alignment 
Range on Protein: 262-327
Range on HMM: 86-149/169.0
RRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRpgSIIGPQQHFLEE
 .|.. . ...  . |||| |. |. . .  | ||.|...  | .....  |  |.| | . ||. 
ykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerr..svikPnkgflkq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 257-317 1.1e-07 25.9 In-house 200-266 (290) alignment 
Range on Protein: 257-317
Range on HMM: 200-266/290.0
SDN-IVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVM-----KHYRFTHAEIIAWIRICRPGSI
  .  . | | |  .. | ..||| ||.|||||..|  |      .   .  ....  .| .| .|.
lstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsv
subfamily_DSP14_pd Subfamily DSP14 268-326 1.8e-07 25.3 In-house 79-135 (157) alignment 
Range on Protein: 268-326
Range on HMM: 79-135/157.0
CENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPgsIIGPQQHFLE
 ....|.. |||.||  |  .|   |.||. . . .|   ... .||  || | . | .
vkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRp..iirPNvGFwk
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 266-327 2.7e-07 24.1 In-house 85-144 (154) alignment 
Range on Protein: 266-327
Range on HMM: 85-144/154.0
NICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPgsIIGPQQHFLEE
.|    .. . ||...|. |. .|.  |.|.. . .  . .  .. .|.  || | | ||. 
aiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsry..iikPnqGflkq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 263-322 3.3e-07 24.1 In-house 212-276 (302) alignment 
Range on Protein: 263-322
Range on HMM: 212-276/302.0
RFLNICENTEGAIAVHCKAGLGRTGTLIAC-YVM----KHYRFTHAEIIAWIRICRPGSIIGPQQ
  |. ||    .. ||| ||.||||||.|  | .    |.     ..|.  .| || |..   ||
dilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
0048567 (Phosphotyrosine protein) phosphatases II 176-227 5.6e-07 24.1 In-house 2-58 (157) alignment 
Range on Protein: 176-227
Range on HMM: 2-58/157.0
VENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPE--AYFPYFKKH---NVTAVVR
.||||...|.|........|.......| .... ..   |...| ..   |.. ..|
kengdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyr
Y_phosphatase Protein-tyrosine phosphatase 260-316 5.7e-07 24.5 Pfam-A 154-219 (235) alignment 
Range on Protein: 260-316
Range on HMM: 154-219/235.0
IVRRFLNICENTE----GAIAVHCKAGLGRTGTLIACYVMKHYRF-----THAEIIAWIRICRPGS
 . .... .|...    | . |||.|| |||||..|  .. .           .|.  .| .|||.
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgm
Y_phosphatase Protein-tyrosine phosphatase 260-316 5.7e-07 24.5 In-house 154-219 (235) alignment 
Range on Protein: 260-316
Range on HMM: 154-219/235.0
IVRRFLNICENTE----GAIAVHCKAGLGRTGTLIACYVMKHYRF-----THAEIIAWIRICRPGS
 . .... .|...    | . |||.|| |||||..|  .. .           .|.  .| .|||.
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgm
PTPlike_phytase Inositol hexakisphosphate 221-295 6e-07 24.2 Pfam-A 74-147 (149) alignment 
Range on Protein: 221-295
Range on HMM: 74-147/149.0
NVTAVVRlnkKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTE--GAIAVHCKAGLGRTGTLIACYVM
..|.|.    ..||.. ..  |.. . .   | . |... | .|........   |. ..|.|| ||| | .... .
tltevte...evyeeelaegfgvkYvRipitdeqapeeedvDafvrlikslprdtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 221-295 6e-07 24.2 In-house 74-147 (149) alignment 
Range on Protein: 221-295
Range on HMM: 74-147/149.0
NVTAVVRlnkKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTE--GAIAVHCKAGLGRTGTLIACYVM
..|.|.    ..||.. ..  |.. . .   | . |... | .|........   |. ..|.|| ||| | .... .
tltevte...evyeeelaegfgvkYvRipitdeqapeeedvDafvrlikslprdtalvfnCqaGrgRTTtamviadL
DSPc_SM00195 260-319 6.3e-07 24.4 In-house 179-247 (263) alignment 
Range on Protein: 260-319
Range on HMM: 179-247/263.0
IVRRFLNICEN----TEGAIAVHCKAGLGRTGTLIACYVM-----KHYRFTHAEIIAWIRICRPGSIIG
 |...|. ...    ..| | |||.||.|||||...  ..     .. ..   ||.  .|  |||..  
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt
PTPc_SM00194 260-319 6.3e-07 24.4 In-house 179-247 (263) alignment 
Range on Protein: 260-319
Range on HMM: 179-247/263.0
IVRRFLNICEN----TEGAIAVHCKAGLGRTGTLIACYVM-----KHYRFTHAEIIAWIRICRPGSIIG
 |...|. ...    ..| | |||.||.|||||...  ..     .. ..   ||.  .|  |||..  
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqt
subfamily_PTPRK_pd Subfamily PTPRK 223-296 7.8e-07 23.2 In-house 163-234 (314) alignment 
Range on Protein: 223-296
Range on HMM: 163-234/314.0
TAVVRLNKKIYEAKRFTDAGFEHYDLFFIdgSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMK
. . |  ..| | ..|   |. ..|       |   ..|||  .  |...| | ||| || ||||| ||. .. 
eklargqeeirevrqfqflgWpdhdvPvs..atgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl
subfamily_DSP8_pd Subfamily DSP8 263-326 1e-06 22.4 In-house 84-145 (159) alignment 
Range on Protein: 263-326
Range on HMM: 84-145/159.0
RFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRpgSIIGPQQHFLE
 |.. . ...| . ||. ||  |  |.. .|.||. ...  |   ...  |    | |.  ||.
efidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr..ptispnlnflg
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 254-294 1.1e-06 22.8 In-house 194-234 (315) alignment 
Range on Protein: 254-294
Range on HMM: 194-234/315.0
STPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYV
..|  |..|.     .|. ||| |||.|| |||||.|.   
tiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitlda
subfamily_STYX_pd Subfamily STYX 213-311 1.5e-06 21.4 In-house 31-135 (166) alignment 
Range on Protein: 213-311
Range on HMM: 31-135/166.0
YFPYFKKHNVTAVVRLNKKIyEAKrFTDAGFE-HYDLFFID-GSTPSDNIVR------RFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAE
 ....||| .| .| . ..| ||. .    |. ..  . .|   .. .||.|       |.. . .. | . || .||. |. .|. .|.|. | . . |
klevlkkhgithivcirqni.ean.likpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyre

IIAWIRI
  |... 
afayvqe
subfamily_PTPN13_pd Subfamily PTPN13 266-314 1.5e-06 22.7 In-house 196-249 (273) alignment 
Range on Protein: 266-314
Range on HMM: 196-249/273.0
NICENTEGAIAVHCKAGLGRTGTLIACYVM-----KHYRFTHAEIIAWIRICRP
.  .. .| |.||| ||.||.||||. .|.     .   |   ||.  .|  | 
rrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrq
subfamily_LRR-DSP_pd Subfamily LRR-DSP 271-325 2e-06 21.1 In-house 196-248 (263) alignment 
Range on Protein: 271-325
Range on HMM: 196-248/263.0
TEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPgsIIGPQQHFL
 .| . |||.||. |. ||. .|.||. |..  | .  .   ||   | | . |.
kkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrp..riqPnpGfk
subfamily_DSP6_pd Subfamily DSP6 264-326 2.4e-06 21.1 In-house 85-145 (158) alignment 
Range on Protein: 264-326
Range on HMM: 85-145/158.0
FLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRpgSIIGPQQHFLE
|..   ... .. ||| ||. |. |.. .|.||.. ..  .  ....  .  | | |  .|..
fidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrk..snisPnfnfmg
subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 268-308 3.2e-06 19.9 In-house 62-102 (128) alignment 
Range on Protein: 268-308
Range on HMM: 62-102/128.0
CENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAW
 ..    . |||. |  ||| ..| ||||.  .   . . |
erelplvlyvhcecgcdrtgevlasyvmkykgydlkkalew
subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 268-308 3.3e-06 19.9 In-house 61-101 (128) alignment 
Range on Protein: 268-308
Range on HMM: 61-101/128.0
CENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAW
 ..    . |||. |  ||| ..| ||||.  .   . . |
erelplvlyvhcecgcdrtgevlasyvmkykgydlkkalew
subfamily_PTPN6_pd Subfamily PTPN6 262-293 3.4e-06 21.3 In-house 217-248 (306) alignment 
Range on Protein: 262-293
Range on HMM: 217-248/306.0
RRFLNICENTEGAIAVHCKAGLGRTGTLIACY
|.  .. |...|.| ||| ||.|||||.|   
rkqeeleeaeagpivvhCsaGiGRtGtfiviD
subfamily_PTPN12_pd Subfamily PTPN12 259-294 6e-06 20.3 In-house 194-229 (290) alignment 
Range on Protein: 259-294
Range on HMM: 194-229/290.0
NIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYV
.... . .. |. .  ..||| || |||||.||   
elielvrelqesedaPlvvhCsaGvGrtGtiiaidy
subfamily_STYXL1_pd Subfamily STYXL1 263-327 6.6e-06 19.4 In-house 83-145 (157) alignment 
Range on Protein: 263-327
Range on HMM: 83-145/157.0
RFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGsiIGPQQHFLEE
.|... .... .. |  . |. |. ..|..|.| ....|. .  . .. |..   . |.. |.| 
qfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCken..vkPnrafveq
subfamily_VSP_pd Subfamily VSP 269-304 7e-06 20.1 In-house 125-160 (212) alignment 
Range on Protein: 269-304
Range on HMM: 125-160/212.0
ENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAE
....  .|.||| | |||||.. .....   |..|.
kdlknvlaihckGGkgrtGtivcalllaseifetak
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 263-331 7.5e-06 20.1 In-house 189-261 (270) alignment 
Range on Protein: 263-331
Range on HMM: 189-261/270.0
RFLNICENTEgAIAVHCKAGLGRTGTLIAC-----YVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQAS
|. .  ...|  . ||| ||.||||||||       . .. .   ..||. .|  |.  .  |.|  .  |  .
rsekeldkae.PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 252-296 9.4e-06 19.5 In-house 199-244 (305) alignment 
Range on Protein: 252-296
Range on HMM: 199-244/305.0
DGSTPSDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIA-CYVMK
 |  ..|. .  .|. .  . | |.||| ||.||||...   |...
rgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyild